Joseph Zaia | Profiles RNS

Joseph Zaia, PhD

Professor

Boston University School of Medicine

Dept of Biochemistry

PhD, Massachusetts Institute of Technology

Websites

	Biochemistry Faculty
	Center for Biomedical Mass Spectrometry Faculty
	Proteoglycan and Glycosaminoglycan Structure Laboratory
	Google Scholar
	ResearchGate
	LinkedIn

ORCID : 0000-0001-9497-8701

The manner in which a cell responds to many growth factor stimuli depends on interactions between glycosaminoglycans (GAGs), growth factors, and growth factor receptors. Extracellular matrix GAGs binds growth factors, creating morphogens gradients essential to tissue patterning. Because these events depend on the fine structure of the GAG chains present, regulation of GAG biosynthesis is a key factor for understanding normal and disease related cellular growth
The key to exploiting an understanding of GAG structure-function relationships for human disease therapy is to winnow oligosaccharide-protein binding patterns from heterogeneous biological preparations. Toward this end, we have developed mass spectral methods for GAGs that enable comparison of structures as a function of biological variables.

The long term research aims are (1) to develop a fundamental understanding of the manner in which glycosaminoglycan expression is varied according to the cellular growth environment related to human disease and (2) to identify HS chain structures useful as therapeutic targets.

New bioinformatics methods are essential to realizing these goals. The data produced using our methods are information rich and not amenable to manual interpretation. Further, the methods needed are distinct from those used in genomics and proteomics. We are developing bioinformatics methods appropriate for interpretation of structural data on glycosaminoglycans and other carbohydrates to identify targets for disease therapy.

Member
Boston University
Bioinformatics Graduate Program

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Genome Science Institute

Center Faculty Member
Boston University School of Medicine
Mass Spectrometry

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Methods for determination of glycoprotein glycosylation similarities among disease states
09/01/2019 - 06/30/2023 (PI)
NIH/National Institute of General Medical Sciences
1R01GM133963-01

Glycomics and proteomics of brain specimens
03/15/2018 - 12/31/2022 (Subcontract PI)
The Scripps Research Institute NIH NIDA
5R01DA046170-02

An open-source software suite for processing glycomics and glycoproteomics mass spectral data
08/14/2017 - 07/31/2020 (PI)
NIH/National Cancer Institute
5U01CA221234-03

Thalamic Axonal Pathways and Extracellular Matrix Abnormalities in Schizophrenia
09/01/2015 - 12/31/2019 (Subcontract PI)
McLean Hospital Corporation NIH NIMH
5R01MH105608-04

Proteomic and glycomic analysis of human brain and lung cancers
07/01/2016 - 06/30/2018 (Subcontract PI)
The Regents of the University of California, San Francisco NIH NCI
4U01CA168878-05

Software for Automated Interpretation of Heparan Sulfate Tandem Mass Spectra
09/15/2015 - 06/30/2018 (PI)
NIH/National Heart, Lung, and Blood Institute
3R21HL131554-02S1

Quantitative Profiling of Glycosaminoglycans from Breast Tumor Tissue Arrays
07/09/2014 - 06/30/2018 (PI)
NIH/National Cancer Institute
5R21CA177479-03

Viral Vector Transduction Deficiencies in the Aged Nigrostriatal System
09/30/2016 - 06/30/2017 (Subcontract PI)
Michigan State University NIH NIA
1R56AG052328-01A1

Quantitative glycomics and proteomics combined with laser capture microdissection
06/01/2013 - 05/21/2017 (PI)
Agilent Technologies, Inc.

A Thermo-Fisher Scientific Q-Exactive HF Mass Spectrometry System
05/01/2016 - 04/30/2017 (PI)
NIH/Office of the Director
1S10OD021651-01

Showing 10 of 20 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2019	Methods for determination of glycoprotein glycosylation similarities among disease states	1R01GM133963-01	4
2019	An open-source software suite for processing glycomics and glycoproteomics mass spectral data	5U01CA221234-03	11
2018	An open-source software suite for processing glycomics and glycoproteomics mass spectral data	5U01CA221234-02	11
2017	An open-source software suite for processing glycomics and glycoproteomics mass spectral data	1U01CA221234-01	11
2016	A Thermo-Fisher Scientific Q-Exactive HF Mass Spectrometry System	1S10OD021651-01	6
2016	Software for automated interpretation of heparan sulfate tandem mass spectra	5R21HL131554-02	10
2016	Software for automated interpretation of heparan sulfate tandem mass spectra	3R21HL131554-02S1	10
2016	Quantitative profiling of glycosaminoglycans from breast tumor tissue arrays	5R21CA177479-03	12
2015	Software for automated interpretation of heparan sulfate tandem mass spectra	1R21HL131554-01	10
2015	Quantitative profiling of glycosaminoglycans from breast tumor tissue arrays	5R21CA177479-02	12

Showing 10 of 134 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Raghunathan R, Hogan JD, Labadorf A, Myers RH, Zaia J. A glycomics and proteomics study of aging and Parkinson's disease in human brain. Sci Rep. 2020 Jul 30; 10(1):12804.View Related Profiles.

Labadorf, Adam
Zaia, Joseph
Raghunathan, Rekha
Myers, Richard

PMID: 32733076

Chang D, Hackett WE, Zhong L, Wan XF, Zaia J. Measuring site-specific glycosylation similarity between influenza A virus variants with statistical certainty. Mol Cell Proteomics. 2020 Jun 29. PMID: 32601173

Yang JE, Rossignol ED, Chang D, Zaia J, Forrester I, Raja K, Winbigler H, Nicastro D, Jackson WT, Bullitt E. Complexity and ultrastructure of infectious extracellular vesicles from cells infected by non-enveloped virus. Sci Rep. 2020 May 14; 10(1):7939.View Related Profiles.

Bullitt, Esther
Rossignol, Evan
Yang, Jie
Zaia, Joseph

PMID: 32409751

Li L, Chang D, Han L, Zhang X, Zaia J, Wan XF. Multi-task learning sparse group lasso: a method for quantifying antigenicity of influenza A(H1N1) virus using mutations and variations in glycosylation of Hemagglutinin. BMC Bioinformatics. 2020 May 11; 21(1):182. PMID: 32393178

Sethi MK, Downs M, Zaia J. Serial in-solution digestion protocol for mass spectrometry-based glycomics and proteomics analysis. Mol Omics. 2020 Apr 20.View Related Profiles.

Zaia, Joseph
Sethi, Manveen

PMID: 32309832

Muraoka S, DeLeo AM, Sethi MK, Yukawa-Takamatsu K, Yang Z, Ko J, Hogan JD, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantla S, Gendelman HE, Issadore D, Zaia J, Ikezu T. Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. Alzheimers Dement. 2020 06; 16(6):896-907.View Related Profiles.

Zaia, Joseph
Sethi, Manveen
Medalla, Maria
Ikezu, Seiko
Ikezu, Tsuneya
Xia, Weiming
You, Yang
Ruan, Zhi

PMID: 32301581

Klein J, Zaia J. Relative Retention Time Estimation Improves N-Glycopeptide Identifications by LC-MS/MS. J Proteome Res. 2020 May 01; 19(5):2113-2121. PMID: 32223173

Klein JA, Zaia J. A Perspective on the Confident Comparison of Glycoprotein Site-Specific Glycosylation in Sample Cohorts. Biochemistry. 2019 Dec 31. PMID: 31833756

Wei J, Tang Y, Bai Y, Zaia J, Costello CE, Hong P, Lin C. Toward Automatic and Comprehensive Glycan Characterization by Online PGC-LC-EED MS/MS. Anal Chem. 2020 01 07; 92(1):782-791.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 31829560

Chang D, Zaia J. Why Glycosylation Matters in Building a Better Flu Vaccine. Mol Cell Proteomics. 2019 12; 18(12):2348-2358. PMID: 31604803

Showing 10 of 186 results. Show More

De Leoz MLA, Duewer DL, Fung A, Liu L, Yau HK, Potter O, Staples GO, Furuki K, Frenkel R, Hu Y, Sosic Z, Zhang P, Altmann F, Gru Nwald-Grube C, Shao C, Zaia J, Evers W, Pengelley S, Suckau D, Wiechmann A, Resemann A, Jabs W, Beck A, Froehlich JW, Huang C, Li Y, Liu Y, Sun S, Wang Y, Seo Y, An HJ, Reichardt NC, Ruiz JE, Archer-Hartmann S, Azadi P, Bell L, Lakos Z, An Y, Cipollo JF, Pucic-Bakovic M, Štambuk J, Lauc G, Li X, Wang PG, Bock A, Hennig R, Rapp E, Creskey M, Cyr TD, Nakano M, Sugiyama T, Leung PA, Link-Lenczowski P, Jaworek J, Yang S, Zhang H, Kelly T, Klapoetke S, Cao R, Kim JY, Lee HK, Lee JY, Yoo JS, Kim SR, Suh SK, de Haan N, Falck D, Lageveen-Kammeijer GSM, Wuhrer M, Emery RJ, Kozak RP, Liew LP, Royle L, Urbanowicz PA, Packer NH, Song X, Everest-Dass A, Lattová E, Cajic S, Alagesan K, Kolarich D, Kasali T, Lindo V, Chen Y, Goswami K, Gau B, Amunugama R, Jones R, Stroop CJM, Kato K, Yagi H, Kondo S, Yuen CT, Harazono A, Shi X, Magnelli PE, Kasper BT, Mahal L, Harvey DJ, O'Flaherty R, Rudd PM, Saldova R, Hecht ES, Muddiman DC, Kang J, Bhoskar P, Menard D, Saati A, Merle C, Mast S, Tep S, Truong J, Nishikaze T, Sekiya S, Shafer A, Funaoka S, Toyoda M, de Vreugd P, Caron C, Pradhan P, Tan NC, Mechref Y, Patil S, Rohrer JS, Chakrabarti R, Dadke D, Lahori M, Zou C, Cairo C, Reiz B, Whittal RM, Lebrilla CB, Wu L, Guttman A, Szigeti M, Kremkow BG, Lee KH, Sihlbom C, Adamczyk B, Jin C, Karlsson NG, Örnros J, Larson G, Nilsson J, Meyer B, Wiegandt A, Komatsu E, Perreault H, Bodnar ED, Said N, Francois YN, Leize-Wagner E, Maier S, Zeck A, Heck AJR, Yang Y, Haselberg R, Yu YQ, Alley W, Leone JW, Yuan H, Stein SE. NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods. Mol Cell Proteomics. 2020 01; 19(1):11-30. PMID: 31591262

Raghunathan R, Sethi MK, Zaia J. On-slide tissue digestion for mass spectrometry based glycomic and proteomic profiling. MethodsX. 2019; 6:2329-2347.View Related Profiles.

Zaia, Joseph
Sethi, Manveen
Raghunathan, Rekha

PMID: 31660297

Jacobsen Á, Shi X, Shao C, Eysturskard J, Mikalsen SO, Zaia J. Characterization of Glycosaminoglycans in Gaping and Intact Connective Tissues of Farmed Atlantic Salmon (Salmo salar) Fillets by Mass Spectrometry. ACS Omega. 2019 Sep 24; 4(13):15337-15347. PMID: 31572832

Raghunathan R, Sethi MK, Klein JA, Zaia J. Proteomics, Glycomics, and Glycoproteomics of Matrisome Molecules. Mol Cell Proteomics. 2019 11; 18(11):2138-2148.View Related Profiles.

Zaia, Joseph
Sethi, Manveen
Raghunathan, Rekha

PMID: 31471497

Wu J, Wei J, Chopra P, Boons GJ, Lin C, Zaia J. Sequencing Heparan Sulfate Using HILIC LC-NETD-MS/MS. Anal Chem. 2019 09 17; 91(18):11738-11746. PMID: 31423779

Klein J, Zaia J. glypy: An Open Source Glycoinformatics Library. J Proteome Res. 2019 09 06; 18(9):3532-3537. PMID: 31310539

Wei J, Wu J, Tang Y, Ridgeway ME, Park MA, Costello CE, Zaia J, Lin C. Characterization and Quantification of Highly Sulfated Glycosaminoglycan Isomers by Gated-Trapped Ion Mobility Spectrometry Negative Electron Transfer Dissociation MS/MS. Anal Chem. 2019 02 19; 91(4):2994-3001.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 30649866

Torres-Arancivia C, Chang D, Zaia J, Connors LH. Structural studies of serum clusterin in ATTRwt amyloidosis. Amyloid. 2019; 26(sup1):51-52.View Related Profiles.

Zaia, Joseph
Connors, Lawreen

PMID: 31343316

Klein J, Zaia J. psims - A Declarative Writer for mzML and mzIdentML for Python. Mol Cell Proteomics. 2019 03; 18(3):571-575. PMID: 30563850

Klein J, Carvalho L, Zaia J. Application of network smoothing to glycan LC-MS profiling. Bioinformatics. 2018 10 15; 34(20):3511-3518. PMID: 29790907

Raghunathan R, Polinski NK, Klein JA, Hogan JD, Shao C, Khatri K, Leon D, McComb ME, Manfredsson FP, Sortwell CE, Zaia J. Glycomic and Proteomic Changes in Aging Brain Nigrostriatal Pathway. Mol Cell Proteomics. 2018 09; 17(9):1778-1787.View Related Profiles.

Shao, Chun
Zaia, Joseph
Khatri, Kshitij
McComb, Mark
Raghunathan, Rekha

PMID: 29915149; DOI: 10.1074/mcp.RA118.000680;

Zaia J, Bierbaum VM. Focus on Mass Spectrometry in Glycobiology and Related Fields, Honoring Catherine E. Costello, Recipient of the 2017 ASMS Award for a Distinguished Contribution in Mass Spectrometry. J Am Soc Mass Spectrom. 2018 06; 29(6):1061-1064. PMID: 29855889

Klein JA, Meng L, Zaia J. Deep Sequencing of Complex Proteoglycans: A Novel Strategy for High Coverage and Site-specific Identification of Glycosaminoglycan-linked Peptides. Mol Cell Proteomics. 2018 08; 17(8):1578-1590. PMID: 29773674

van Eijk M, Rynkiewicz MJ, Khatri K, Leymarie N, Zaia J, White MR, Hartshorn KL, Cafarella TR, van Die I, Hessing M, Seaton BA, Haagsman HP. Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus. J Biol Chem. 2018 07 06; 293(27):10646-10662.View Related Profiles.

Seaton, Barbara
Zaia, Joseph
Hartshorn, Kevan
Khatri, Kshitij
Rynkiewicz, Michael
Leymarie, Nancy

PMID: 29769321

Khatri K, Pu Y, Klein JA, Wei J, Costello CE, Lin C, Zaia J. Comparison of Collisional and Electron-Based Dissociation Modes for Middle-Down Analysis of Multiply Glycosylated Peptides. J Am Soc Mass Spectrom. 2018 06; 29(6):1075-1085.View Related Profiles.

Costello, Catherine
Zaia, Joseph
Khatri, Kshitij

PMID: 29663256

Hogan JD, Klein JA, Wu J, Chopra P, Boons GJ, Carvalho L, Lin C, Zaia J. Software for Peak Finding and Elemental Composition Assignment for Glycosaminoglycan Tandem Mass Spectra. Mol Cell Proteomics. 2018 07; 17(7):1448-1456. PMID: 29615495

Wu J, Wei J, Hogan JD, Chopra P, Joshi A, Lu W, Klein J, Boons GJ, Lin C, Zaia J. Negative Electron Transfer Dissociation Sequencing of 3-O-Sulfation-Containing Heparan Sulfate Oligosaccharides. J Am Soc Mass Spectrom. 2018 06; 29(6):1262-1272. PMID: 29564812

Turiák L, Tóth G, Ozohanics O, Révész Á, Ács A, Vékey K, Zaia J, Drahos L. Sensitive method for glycosaminoglycan analysis of tissue sections. J Chromatogr A. 2018 Apr 06; 1544:41-48.View Related Profiles.

Zaia, Joseph
Turiak, Lilla

PMID: 29506752

Wu ZL, Person AD, Anderson M, Burroughs B, Tatge T, Khatri K, Zou Y, Wang L, Geders T, Zaia J, Sackstein R. Imaging specific cellular glycan structures using glycosyltransferases via click chemistry. Glycobiology. 2018 02 01; 28(2):69-79.View Related Profiles.

Zaia, Joseph
Khatri, Kshitij

PMID: 29186441

Chen J, Kawamura T, Sethi MK, Zaia J, Repunte-Canonigo V, Sanna PP. Heparan sulfate: Resilience factor and therapeutic target for cocaine abuse. Sci Rep. 2017 10 24; 7(1):13931.View Related Profiles.

Zaia, Joseph
Sethi, Manveen

PMID: 29066725

Khatri K, Klein JA, Haserick JR, Leon DR, Costello CE, McComb ME, Zaia J. Microfluidic Capillary Electrophoresis-Mass Spectrometry for Analysis of Monosaccharides, Oligosaccharides, and Glycopeptides. Anal Chem. 2017 06 20; 89(12):6645-6655.View Related Profiles.

Costello, Catherine
Haserick, John
Zaia, Joseph
Khatri, Kshitij
McComb, Mark

PMID: 28530388

Wu ZL, Huang X, Ethen CM, Tatge T, Pasek M, Zaia J. Non-reducing end labeling of heparan sulfate via click chemistry and a high throughput ELISA assay for heparanase. Glycobiology. 2017 Jun 01; 27(6):518-524. PMID: 28025251; DOI: 10.1093/glycob/cww130;

Glaskin RS, Khatri K, Wang Q, Zaia J, Costello CE. Construction of a Database of Collision Cross Section Values for Glycopeptides, Glycans, and Peptides Determined by IM-MS. Anal Chem. 2017 04 18; 89(8):4452-4460.View Related Profiles.

Costello, Catherine
Zaia, Joseph
Khatri, Kshitij
Wang, Qi
Glaskin, Rebecca

PMID: 28323417; DOI: 10.1021/acs.analchem.6b04146;

Wu ZL, Huang X, Ethen CM, Tatge T, Pasek M, Zaia J. Non-reducing end labeling of heparan sulfate via click chemistry and a high throughput ELISA assay for heparanase. Glycobiology. 2017 Feb 06; 1-7. PMID: 28173134; DOI: 10.1093/glycob/cww130;

Liu Y, McBride R, Stoll M, Palma AS, Silva L, Agravat S, Aoki-Kinoshita KF, Campbell MP, Costello CE, Dell A, Haslam SM, Karlsson NG, Khoo KH, Kolarich D, Novotny MV, Packer NH, Ranzinger R, Rapp E, Rudd PM, Struwe WB, Tiemeyer M, Wells L, York WS, Zaia J, Kettner C, Paulson JC, Feizi T, Smith DF. The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting glycan microarray-based data. Glycobiology. 2017 04; 27(4):280-284.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 27993942

Zaia J, Khatri K, Klein J, Shao C, Sheng Y, Viner R. Complete Molecular Weight Profiling of Low-Molecular Weight Heparins Using Size Exclusion Chromatography-Ion Suppressor-High-Resolution Mass Spectrometry. Anal Chem. 2016 11 01; 88(21):10654-10660.View Related Profiles.

Shao, Chun
Zaia, Joseph
Khatri, Kshitij

PMID: 27709905

Khatri K, Klein JA, Zaia J. Use of an informed search space maximizes confidence of site-specific assignment of glycoprotein glycosylation. Anal Bioanal Chem. 2017 Jan; 409(2):607-618.View Related Profiles.

Zaia, Joseph
Khatri, Kshitij

PMID: 27734143; DOI: 10.1007/s00216-016-9970-5;

Dierker T, Shao C, Haitina T, Zaia J, Hinas A, Kjellén L. Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans. Sci Rep. 2016 10 05; 6:34662. PMID: 27703236; DOI: 10.1038/srep34662;

Struwe WB, Agravat S, Aoki-Kinoshita KF, Campbell MP, Costello CE, Dell A, Ten Feizi, Haslam SM, Karlsson NG, Khoo KH, Kolarich D, Liu Y, McBride R, Novotny MV, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Tiemeyer M, Wells L, York WS, Zaia J, Kettner C. The minimum information required for a glycomics experiment (MIRAGE) project: sample preparation guidelines for reliable reporting of glycomics datasets. Glycobiology. 2016 Sep; 26(9):907-910.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 27654115

Sethi MK, Zaia J. Extracellular matrix proteomics in schizophrenia and Alzheimer's disease. Anal Bioanal Chem. 2017 Jan; 409(2):379-394.View Related Profiles.

Zaia, Joseph
Sethi, Manveen

PMID: 27601046; DOI: 10.1007/s00216-016-9900-6;

He H, Liu D, Lin H, Jiang S, Ying Y, Chun S, Deng H, Zaia J, Wen R, Luo Z. Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein and has multiple functions. Biochim Biophys Acta. 2016 Jul; 1863(7 Pt A):1682-9.View Related Profiles.

Zaia, Joseph
Luo, Zhijun

PMID: 27033522; DOI: 10.1016/j.bbamcr.2016.03.022;

Khatri K, Klein JA, White MR, Grant OC, Leymarie N, Woods RJ, Hartshorn KL, Zaia J. Integrated Omics and Computational Glycobiology Reveal Structural Basis for Influenza A Virus Glycan Microheterogeneity and Host Interactions. Mol Cell Proteomics. 2016 Jun; 15(6):1895-912.View Related Profiles.

Zaia, Joseph
Hartshorn, Kevan
Khatri, Kshitij
Leymarie, Nancy

PMID: 26984886; DOI: 10.1074/mcp.M116.058016;

Hu H, Khatri K, Zaia J. Algorithms and design strategies towards automated glycoproteomics analysis. Mass Spectrom Rev. 2017 07; 36(4):475-498.View Related Profiles.

Zaia, Joseph
Khatri, Kshitij

PMID: 26728195; DOI: 10.1002/mas.21487;

Hu H, Mao Y, Huang Y, Lin C, Zaia J. Bioinformatics of glycosaminoglycans. Perspectives in Science. 2016; 11(C). View Publication

Tykesson E, Mao Y, Maccarana M, Pu Y, Gao J, Lin C, Zaia J, Westergren-Thorsson G, Ellervik U, Malmström L, Malmström A. Deciphering the Mode of Action of the Processive Polysaccharide Modifying Enzyme Dermatan Sulfate Epimerase 1 by Hydrogen-Deuterium Exchange Mass Spectrometry. Chem Sci. 2016 Feb 01; 7(2):1447-1456.View Related Profiles.

Lin, Cheng
Zaia, Joseph
Mao, Yang

PMID: 26900446

Hu H, Khatri K, Klein J, Leymarie N, Zaia J. A review of methods for interpretation of glycopeptide tandem mass spectral data. Glycoconj J. 2016 Jun; 33(3):285-96.View Related Profiles.

Zaia, Joseph
Khatri, Kshitij
Leymarie, Nancy

PMID: 26612686; PMCID: PMC4882288; DOI: 10.1007/s10719-015-9633-3;

Aoki-Kinoshita K, Agravat S, Aoki NP, Arpinar S, Cummings RD, Fujita A, Fujita N, Hart GM, Haslam SM, Kawasaki T, Matsubara M, Moreman KW, Okuda S, Pierce M, Ranzinger R, Shikanai T, Shinmachi D, Solovieva E, Suzuki Y, Tsuchiya S, Yamada I, York WS, Zaia J, Narimatsu H. GlyTouCan 1.0--The international glycan structure repository. Nucleic Acids Res. 2016 Jan 4; 44(D1):D1237-42. PMID: 26476458; PMCID: PMC4702779; DOI: 10.1093/nar/gkv1041;

Salanti A, Clausen TM, Agerbæk MØ, Al Nakouzi N, Dahlbäck M, Oo HZ, Lee S, Gustavsson T, Rich JR, Hedberg BJ, Mao Y, Barington L, Pereira MA, LoBello J, Endo M, Fazli L, Soden J, Wang CK, Sander AF, Dagil R, Thrane S, Holst PJ, Meng L, Favero F, Weiss GJ, Nielsen MA, Freeth J, Nielsen TO, Zaia J, Tran NL, Trent J, Babcook JS, Theander TG, Sorensen PH, Daugaard M. Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein. Cancer Cell. 2015 Oct 12; 28(4):500-14.View Related Profiles.

Zaia, Joseph
Mao, Yang

PMID: 26461094; PMCID: PMC4790448; DOI: 10.1016/j.ccell.2015.09.003;

Aoki NP, Aoki-Kinoshita KF, Agravat S, Zaia J et. al. Annual Meeting of the Society-for-Glycobiology on Glycobiology. The Official Release of the International Glycan Structure Repository. Glycobiology. 2015.
Zaia J, Klein J, Khatri K, Yip S. GlyrReSoft: A tool for assigning sites specific glycoprotein glycosylation from integrated omics data using rigorous statistics. Annual Meeting of the Society-for-Glycobiology on Glycobiology. 2015.
Shao C, Klein J, Turiak L, Phillips J, Zaia J. Annual Meeting of the Society-for-Glycobiology on Glycobiology. Dysregulation of proteoglycan expression in astrocytoma: assessment using an integrated omics approach. Glycobiology. 2015.
Khatri K, Klein J, White MR, Grant OC, Leymarie N, Woods RJ, Hartshorn KL, Zaia J. Annual Meeting of the Society-for-Glycobiology on Glycobiology. Understanding glycan mediated interactions of the Influenza A virus with host immune system using integrated omics and computational glycobiology. Glycobiology. 2015; 25.

Huang Y, Mao Y, Zong C, Lin C, Boons GJ, Zaia J. Discovery of a heparan sulfate 3-O-sulfation specific peeling reaction. Anal Chem. 2015 Jan 6; 87(1):592-600.View Related Profiles.

Lin, Cheng
Zaia, Joseph
Mao, Yang
Huang, Yu

PMID: 25486437; PMCID: PMC4287833; DOI: 10.1021/ac503248k;

Reine TM, Kolseth IB, Meen AJ, Lindahl JP, Jenssen TG, Reinholt FP, Zaia J, Shao C, Hartmann A, Kolset SO. Effects of restoring normoglycemia in type 1 diabetes on inflammatory profile and renal extracellular matrix structure after simultaneous pancreas and kidney transplantation. Diabetes Res Clin Pract. 2015 Jan; 107(1):46-53. PMID: 25467621; PMCID: PMC4324617; DOI: 10.1016/j.diabres.2014.10.006;

Mao Y, Huang Y, Buczek-Thomas JA, Ethen CM, Nugent MA, Wu ZL, Zaia J. A liquid chromatography-mass spectrometry-based approach to characterize the substrate specificity of mammalian heparanase. J Biol Chem. 2014 Dec 5; 289(49):34141-51.View Related Profiles.

Zaia, Joseph
Nugent, Matthew
Mao, Yang
Huang, Yu

PMID: 25336655; PMCID: PMC4256347; DOI: 10.1074/jbc.M114.589630;

Turiák L, Shao C, Meng L, Khatri K, Leymarie N, Wang Q, Pantazopoulos H, Leon DR, Zaia J. Workflow for combined proteomics and glycomics profiling from histological tissues. Anal Chem. 2014 Oct 7; 86(19):9670-8.View Related Profiles.

Shao, Chun
Zaia, Joseph
Khatri, Kshitij
Turiak, Lilla
Leymarie, Nancy
Wang, Qi

PMID: 25203838; PMCID: PMC4427244; DOI: 10.1021/ac5022216;

Khatri K, Staples GO, Leymarie N, Leon DR, Turiák L, Huang Y, Yip S, Hu H, Heckendorf CF, Zaia J. Confident assignment of site-specific glycosylation in complex glycoproteins in a single step. J Proteome Res. 2014 Oct 3; 13(10):4347-55.View Related Profiles.

Zaia, Joseph
Khatri, Kshitij
Turiak, Lilla
Leymarie, Nancy
Huang, Yu

PMID: 25153361; PMCID: PMC4184449; DOI: 10.1021/pr500506z;

Huang Y, Mao Y, Buczek-Thomas JA, Nugent MA, Zaia J. Oligosaccharide substrate preferences of human extracellular sulfatase Sulf2 using liquid chromatography-mass spectrometry based glycomics approaches. PLoS One. 2014; 9(8):e105143.View Related Profiles.

Zaia, Joseph
Nugent, Matthew
Mao, Yang
Huang, Yu

PMID: 25127119; PMCID: PMC4134258; DOI: 10.1371/journal.pone.0105143;

Hu H, Huang Y, Mao Y, Yu X, Xu Y, Liu J, Zong C, Boons GJ, Lin C, Xia Y, Zaia J. A computational framework for heparan sulfate sequencing using high-resolution tandem mass spectra. Mol Cell Proteomics. 2014 Sep; 13(9):2490-502.View Related Profiles.

Lin, Cheng
Zaia, Joseph
Mao, Yang
Huang, Yu

PMID: 24925905; PMCID: PMC4159664; DOI: 10.1074/mcp.M114.039560;

Wu ZL, Robey MT, Tatge T, Lin C, Leymarie N, Zou Y, Zaia J. Detecting O-GlcNAc using in vitro sulfation. Glycobiology. 2014 Aug; 24(8):740-7.View Related Profiles.

Lin, Cheng
Zaia, Joseph
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PMID: 24799377; PMCID: PMC4070980; DOI: 10.1093/glycob/cwu037;

York WS, Agravat S, Aoki-Kinoshita KF, McBride R, Campbell MP, Costello CE, Dell A, Feizi T, Haslam SM, Karlsson N, Khoo KH, Kolarich D, Liu Y, Novotny M, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Struwe WB, Tiemeyer M, Wells L, Zaia J, Kettner C. MIRAGE: the minimum information required for a glycomics experiment. Glycobiology. 2014 May; 24(5):402-6.View Related Profiles.

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PMID: 24653214; PMCID: PMC3976285; DOI: 10.1093/glycob/cwu018;

Aoki-Kinoshita KF, Agravat S, Aoki NP, Zaia J et. al. Joint Meeting of the Society-for-Glycobiology (SFG). Development of an International Glycan Structure Repository. Glycobiology. 2014; 24.

Hu H, Dittwald P, Zaia J, Valkenborg D. Comment on "Computation of isotopic peak center-mass distribution by fourier transform". Anal Chem. 2013 Dec 17; 85(24):12189-92. PMID: 24187947; PMCID: PMC4119064; DOI: 10.1021/ac402731h;

Huang Y, Yu X, Mao Y, Costello CE, Zaia J, Lin C. De novo sequencing of heparan sulfate oligosaccharides by electron-activated dissociation. Anal Chem. 2013 Dec 17; 85(24):11979-86.View Related Profiles.

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PMID: 24224699; PMCID: PMC3912864; DOI: 10.1021/ac402931j;

Mathias DK, Pastrana-Mena R, Ranucci E, Tao D, Ferruti P, Ortega C, Staples GO, Zaia J, Takashima E, Tsuboi T, Borg NA, Verotta L, Dinglasan RR. A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut. PLoS Pathog. 2013; 9(11):e1003757. PMID: 24278017; PMCID: PMC3836724; DOI: 10.1371/journal.ppat.1003757;

Ramachandra R, Namburi RB, Ortega-Martinez O, Shi X, Zaia J, Dupont ST, Thorndyke MC, Lindahl U, Spillmann D. Brittlestars contain highly sulfated chondroitin sulfates/dermatan sulfates that promote fibroblast growth factor 2-induced cell signaling. Glycobiology. 2014 Feb; 24(2):195-207. PMID: 24253764; PMCID: PMC3907082; DOI: 10.1093/glycob/cwt100;

Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide. Immunology. 2013 Nov; 140(3):374-89.View Related Profiles.

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PMID: 23844703; PMCID: PMC3800442; DOI: 10.1111/imm.12150;

Shao C, Shi X, Phillips JJ, Zaia J. Mass spectral profiling of glycosaminoglycans from histological tissue surfaces. Anal Chem. 2013 Nov 19; 85(22):10984-91.View Related Profiles.

Shao, Chun
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PMID: 24099043; PMCID: PMC3872031; DOI: 10.1021/ac402517s;

Nugent MA, Zaia J, Spencer JL. Heparan sulfate-protein binding specificity. Biochemistry (Mosc). 2013 Jul; 78(7):726-35.View Related Profiles.

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PMID: 24010836; PMCID: PMC4108213; DOI: 10.1134/S0006297913070055;

Leymarie N, Griffin PJ, Jonscher K, Kolarich D, Orlando R, McComb M, Zaia J, Aguilan J, Alley WR, Altmann F, Ball LE, Basumallick L, Bazemore-Walker CR, Behnken H, Blank MA, Brown KJ, Bunz SC, Cairo CW, Cipollo JF, Daneshfar R, Desaire H, Drake RR, Go EP, Goldman R, Gruber C, Halim A, Hathout Y, Hensbergen PJ, Horn DM, Hurum D, Jabs W, Larson G, Ly M, Mann BF, Marx K, Mechref Y, Meyer B, Möginger U, Neusüß C, Nilsson J, Novotny MV, Nyalwidhe JO, Packer NH, Pompach P, Reiz B, Resemann A, Rohrer JS, Ruthenbeck A, Sanda M, Schulz JM, Schweiger-Hufnagel U, Sihlbom C, Song E, Staples GO, Suckau D, Tang H, Thaysen-Andersen M, Viner RI, An Y, Valmu L, Wada Y, Watson M, Windwarder M, Whittal R, Wuhrer M, Zhu Y, Zou C. Interlaboratory study on differential analysis of protein glycosylation by mass spectrometry: the ABRF glycoprotein research multi-institutional study 2012. Mol Cell Proteomics. 2013 Oct; 12(10):2935-51.View Related Profiles.

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PMID: 23764502; PMCID: PMC3790302; DOI: 10.1074/mcp.M113.030643;

Shi X, Shao C, Mao Y, Huang Y, Wu ZL, Zaia J. LC-MS and LC-MS/MS studies of incorporation of 34SO3 into glycosaminoglycan chains by sulfotransferases. Glycobiology. 2013 Aug; 23(8):969-79.View Related Profiles.

Shao, Chun
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PMID: 23696150; PMCID: PMC3695753; DOI: 10.1093/glycob/cwt033;

Shao C, Shi X, White M, Huang Y, Hartshorn K, Zaia J. Comparative glycomics of leukocyte glycosaminoglycans. FEBS J. 2013 May; 280(10):2447-61.View Related Profiles.

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PMID: 23480678; PMCID: PMC3651794; DOI: 10.1111/febs.12231;

Kolarich D, Rapp E, Struwe WB, Haslam SM, Zaia J, McBride R, Agravat S, Campbell MP, Kato M, Ranzinger R, Kettner C, York WS. The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting mass-spectrometry-based glycoanalytic data. Mol Cell Proteomics. 2013 Apr; 12(4):991-5. PMID: 23378518; PMCID: PMC3617344; DOI: 10.1074/mcp.O112.026492;

Zaia J. Glycosaminoglycan glycomics using mass spectrometry. Mol Cell Proteomics. 2013 Apr; 12(4):885-92. PMID: 23325770; PMCID: PMC3617335; DOI: 10.1074/mcp.R112.026294;

Gill VL, Aich U, Rao S, Pohl C, Zaia J. Disaccharide analysis of glycosaminoglycans using hydrophilic interaction chromatography and mass spectrometry. Anal Chem. 2013 Jan 15; 85(2):1138-45. PMID: 23234263; PMCID: PMC3557806; DOI: 10.1021/ac3030448;

Zaia J. Capillary electrophoresis-mass spectrometry of carbohydrates. Methods Mol Biol. 2013; 984:13-25. PMID: 23386333; DOI: 10.1007/978-1-62703-296-4_2;

Leymarie N, Griffin PJ, Xing C, Jonscher K, Kolarich D, Orlando R. Mccomb ME, Zaia J. 61st ASMS Conference on Mass Spectrometry and Allied Topics. Ability of the glycoproteomics comminuty to profile N-glycosylation of prostate specific antigen by mass spectrometry: an ABRF 2013 Interlaboratory Study. 2013.
Thaysen-Andersen M, Suckau D, Jonscher K, Kolarich D, Orlando R, Mccomb ME, Zaia J, Neymarie N. Glycoprotein Research Group (gPRG) 2013 Interlaboratory Study: Quantitative N-glycan Profiling of Prostate Specific Antigen. Journal of biomolecular techniques: JBT. 2013; 24(Suppl):S71.

Li L, Zhang F, Zaia J, Linhardt RJ. Top-down approach for the direct characterization of low molecular weight heparins using LC-FT-MS. Anal Chem. 2012 Oct 16; 84(20):8822-9. PMID: 22985071; PMCID: PMC3479637; DOI: 10.1021/ac302232c;

Maxwell E, Tan Y, Tan Y, Hu H, Benson G, Aizikov K, Conley S, Staples GO, Slysz GW, Smith RD, Zaia J. GlycReSoft: a software package for automated recognition of glycans from LC/MS data. PLoS One. 2012; 7(9):e45474.View Related Profiles.

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PMID: 23049804; PMCID: PMC3458864; DOI: 10.1371/journal.pone.0045474;

Gill VL, Wang Q, Shi X, Zaia J. Mass spectrometric method for determining the uronic acid epimerization in heparan sulfate disaccharides generated using nitrous acid. Anal Chem. 2012 Sep 4; 84(17):7539-46.View Related Profiles.

Zaia, Joseph
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PMID: 22873817; PMCID: PMC3437266; DOI: 10.1021/ac3016054;

Tran TH, Shi X, Zaia J, Ai X. Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration. J Biol Chem. 2012 Sep 21; 287(39):32651-64.View Related Profiles.

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PMID: 22865881; PMCID: PMC3463311

Shi X, Huang Y, Mao Y, Naimy H, Zaia J. Tandem mass spectrometry of heparan sulfate negative ions: sulfate loss patterns and chemical modification methods for improvement of product ion profiles. J Am Soc Mass Spectrom. 2012 Sep; 23(9):1498-511.View Related Profiles.

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Shi, Xiaofeng
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PMID: 22825743; DOI: 10.1007/s13361-012-0429-4;

Lu Z, Madico G, Roche MI, Wang Q, Hui JH, Perkins HM, Zaia J, Costello CE, Sharon J. Protective B-cell epitopes of Francisella tularensis O-polysaccharide in a mouse model of respiratory tularaemia. Immunology. 2012 Jul; 136(3):352-60.View Related Profiles.

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PMID: 22486311; PMCID: PMC3385035; DOI: 10.1111/j.1365-2567.2012.03589.x;

Leymarie N, Zaia J. Effective use of mass spectrometry for glycan and glycopeptide structural analysis. Anal Chem. 2012 Apr 3; 84(7):3040-8.View Related Profiles.

Zaia, Joseph
Leymarie, Nancy

PMID: 22360375; PMCID: PMC3319649; DOI: 10.1021/ac3000573;

Thelin MA, Svensson KJ, Shi X, Bagher M, Axelsson J, Isinger-Ekstrand A, van Kuppevelt TH, Johansson J, Nilbert M, Zaia J, Belting M, Maccarana M, Malmström A. Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma. Cancer Res. 2012 Apr 15; 72(8):1943-52. PMID: 22350411; PMCID: PMC3328612; DOI: 10.1158/0008-5472.CAN-11-1351;

Rosas-Alquicira G, Acosta-Blano I, Ortega-Francisco S, Fuentes-Romero LL, Newburg DS, Ruiz-Palacios G, Mao Y, Zaia J, Viveros-Rogel M. Joint Meeting of the Society for Glycobiology and American Society for Matrix Biology. Human milk Glycosaminoglycans inhibit HIV-1 primary isolate in vitro infection. Glycobiology Journal. San Diego. 2012; 22(11):1632.
Mao Y, Huang Y, Wu L, Zaia J. Joint Meeting of the Society-for-Glycobiology. Characterization of the substratum specificity of mammalian heparanase using the aglycomic approach. Glycobiology. 2012; 22.
Jonscher K, Kolarich D, Zaia J, Leymarie N. (gPRG) 2012 Quantitative Glycoprotein Study. Journal of biomolecular techniques: JBT. 2012; 23(Suppl):S16-S17.
Staples GO, Zaia J. Analysis of Glycosaminoglycans Using Mass Spectrometry. Curr Proteomics. 2011; 8:325-336. View Publication

Wang Q, Shi X, Leymarie N, Madico G, Sharon J, Costello CE, Zaia J. A typical preparation of Francisella tularensis O-antigen yields a mixture of three types of saccharides. Biochemistry. 2011 Dec 20; 50(50):10941-50.View Related Profiles.

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PMID: 22091710; PMCID: PMC3238095; DOI: 10.1021/bi201450v;

Huang Y, Shi X, Yu X, Leymarie N, Staples GO, Yin H, Killeen K, Zaia J. Improved liquid chromatography-MS/MS of heparan sulfate oligosaccharides via chip-based pulsed makeup flow. Anal Chem. 2011 Nov 1; 83(21):8222-9.View Related Profiles.

Zaia, Joseph
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PMID: 21923145; PMCID: PMC3205275; DOI: 10.1021/ac201964n;

Crouch E, Nikolaidis N, McCormack FX, McDonald B, Allen K, Rynkiewicz MJ, Cafarella TM, White M, Lewnard K, Leymarie N, Zaia J, Seaton BA, Hartshorn KL. Mutagenesis of surfactant protein D informed by evolution and x-ray crystallography enhances defenses against influenza A virus in vivo. J Biol Chem. 2011 Nov 25; 286(47):40681-92.View Related Profiles.

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Zaia, Joseph
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PMID: 21965658; PMCID: PMC3220461; DOI: 10.1074/jbc.M111.300673;

Bielik AM, Zaia J. Multistage Tandem Mass Spectrometry of Chondroitin Sulfate and Dermatan Sulfate. Int J Mass Spectrom. 2011 Aug 15; 305(2-3):131-137. PMID: 21860601; DOI: 10.1016/j.ijms.2010.10.017;

Leymarie N, McComb ME, Naimy H, Staples GO, Zaia J. Differential Characterization and Classification of Tissue Specific Glycosaminoglycans by Tandem Mass Spectrometry and Statistical Methods. Int J Mass Spectrom. 2012 Feb 15; 312:144-154.View Related Profiles.

Zaia, Joseph
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PMID: 22523474; DOI: 10.1016/j.ijms.2011.07.019;

Schumacher VA, Schlötzer-Schrehardt U, Karumanchi SA, Shi X, Zaia J, Jeruschke S, Zhang D, Pavenstädt H, Pavenstaedt H, Drenckhan A, Amann K, Ng C, Hartwig S, Ng KH, Ho J, Kreidberg JA, Taglienti M, Royer-Pokora B, Ai X. WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J Am Soc Nephrol. 2011 Jul; 22(7):1286-96.View Related Profiles.

Zaia, Joseph
Ai, Xingbin

PMID: 21719793; PMCID: PMC3137576; DOI: 10.1681/ASN.2010080860;

Naimy H, Buczek-Thomas JA, Nugent MA, Leymarie N, Zaia J. Highly sulfated nonreducing end-derived heparan sulfate domains bind fibroblast growth factor-2 with high affinity and are enriched in biologically active fractions. J Biol Chem. 2011 Jun 3; 286(22):19311-9.View Related Profiles.

Buczek-Thomas, JoAnn
Zaia, Joseph
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PMID: 21471211; PMCID: PMC3103309; DOI: 10.1074/jbc.M110.204693;

Staples GO, Shi X, Zaia J. Glycomics analysis of mammalian heparan sulfates modified by the human extracellular sulfatase HSulf2. PLoS One. 2011; 6(2):e16689.View Related Profiles.

Zaia, Joseph
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PMID: 21347431; PMCID: PMC3035651; DOI: 10.1371/journal.pone.0016689;

Zaia J. At last, functional glycomics. Nat Methods. 2011 Jan; 8(1):55-7. PMID: 21191374; DOI: 10.1038/nmeth0111-55;

Staples GO, Zaia J. In Carbohydrate Recognition; Wang B, Boons GJ, Eds. John Wiley & Sons, Inc. Hoboken. 2011; 257-300.

Staples GO, Zaia J. Analysis of Glycosaminoglycans Using Mass Spectrometry. Curr Proteomics. 2011; 8(4):325-336. PMID: 25705143

Leymarie N, Hartshorn K, White MR, Cafarella T, Seaton B, Rynkiewicz MJ, Zaia J. Annual Conference of the Society-for-Glycobiology. Studies on Site-Specific N-Glycosylation of Hemagglutinin from Influenza AViruse Phil82 and Surfactant Protein D. Glycobiology. 2011.
Bielik A, Mcleod E, Landry D, Mendoza V, Zaia J, Guthrie EP. Annual Conference of the Society-for-Glycobiology. Characterization of Three Novel Heparinases Cloned from Bacteroides eggerthii. Glycobiology. 2011; 21.
Huang Yu Shi X, Zaia J. Annual Conference of the Society-for-Glycobiology. LC-MS and LC-MS/MS Study of Heparan Sulfate Oligosaccharides Processed by Human Sulf-2. Glycobiology. 2011; 21.
Mao Y, Newburg DS, Costello CE, Zaia J. Annual Conference of the Society-for-Glycobiology. Comparative Glycomics of Human and Bovine Milk Glycosaminoglycans. Gylcobiology. 2011; 21.
Kolarich D, Orlando R, Zaia J. gPRG: Toward Consensus on Glycan Analysis: Reliable Methods and Reproducibility. Journal of biomolecular techniques: JBT. 2011; 22(Suppl):S22.
Staples G, Zaia J. Carbohydrate Recognition: Biological Problems, Methods, and Applications. Mass Spectrometry in Carbohydrate Sequencing and Binding Analysis. 2011; 257-300. View Publication
Rynkiewicz MJ, Luo D, Leymarie N, Crouch EC, Hartshorn KL, Head JF, Mccormack FX, van Eijk M, Zaia J, Seaton BA. Mechanisms of Interaction Between Lung Collectins and Influenza a Virus Hemagglutinin. Biophysical Journal. 2011; 100(3). View Publication
Hollingsworth MT, Hart GW, Paulson JC, Lebrilla C, Zaia J et al. Glycobiology. Program and abstracts for the 2011 Meeting of the Society for Glycobiology. 2011; 21(11):1454-1531. View Publication
Hollingsworth MT, Hart GW, Paulson JC, Lebrilla C, Zaia J et al. Glycobiology. Program and abstracts for the 2011 Meeting of the Society for Glycobiology. 2011; 21(11):1454-1531. View Publication
Naimy H, Leymarie N, Buczek-Thomas JA, Nugent MA, Zaia J. Annual Conference of the Society-for-Glycobiology. Characterization of Heparan Sulfate N-Sulfated Domains Binding Fibroblast Growth Factor-2. Glycobiology. 2011; 20.

Dreyfuss JM, Jacobs C, Gindin Y, Benson G, Staples GO, Zaia J. Targeted analysis of glycomics liquid chromatography/mass spectrometry data. Anal Bioanal Chem. 2011 Jan; 399(2):727-35. PMID: 20953780; PMCID: PMC3254673; DOI: 10.1007/s00216-010-4235-1;

Langsdorf A, Schumacher V, Shi X, Tran T, Zaia J, Jain S, Taglienti M, Kreidberg JA, Fine A, Ai X. Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche. Glycobiology. 2011 Feb; 21(2):152-61.View Related Profiles.

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Zaia, Joseph
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PMID: 20855470; PMCID: PMC3031337; DOI: 10.1093/glycob/cwq133;

Zaia J. Mass spectrometry and glycomics. OMICS. 2010 Aug; 14(4):401-18. PMID: 20443730; PMCID: PMC3133787; DOI: 10.1089/omi.2009.0146;

Naimy H, Leymarie N, Zaia J. Screening for anticoagulant heparan sulfate octasaccharides and fine structure characterization using tandem mass spectrometry. Biochemistry. 2010 May 4; 49(17):3743-52.View Related Profiles.

Zaia, Joseph
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PMID: 20345121; PMCID: PMC3251171; DOI: 10.1021/bi100135d;

Staples GO, Shi X, Zaia J. Extended N-sulfated domains reside at the nonreducing end of heparan sulfate chains. J Biol Chem. 2010 Jun 11; 285(24):18336-43.View Related Profiles.

Zaia, Joseph
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PMID: 20363743; PMCID: PMC2881759; DOI: 10.1074/jbc.M110.101592;

Bowman MJ, Zaia J. Comparative glycomics using a tetraplex stable-isotope coded tag. Anal Chem. 2010 Apr 1; 82(7):3023-31. PMID: 20230064; PMCID: PMC2854645; DOI: 10.1021/ac100108w;

Staples GO, Naimy H, Yin H, Kileen K, Kraiczek K, Costello CE, Zaia J. Improved hydrophilic interaction chromatography LC/MS of heparinoids using a chip with postcolumn makeup flow. Anal Chem. 2010 Jan 15; 82(2):516-22.View Related Profiles.

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PMID: 20000724; PMCID: PMC3247906; DOI: 10.1021/ac901706f;

Bielik AM, Zaia J. Historical overview of glycoanalysis. Methods Mol Biol. 2010; 600:9-30. PMID: 19882118; DOI: 10.1007/978-1-60761-454-8_2;

Bielik AM, Zaia J. Extraction of chondroitin/dermatan sulfate glycosaminoglycans from connective tissue for mass spectrometric analysis. Methods Mol Biol. 2010; 600:215-25. PMID: 19882131; DOI: 10.1007/978-1-60761-454-8_15;

Huang Y, Shi X, Yin H, Staples G, Killeen K, Zaia J. Annual Conference of the Society-for-Glycobiology. Improved Heparan Sulfate Oligosaccharide Structural Analysis using LC-Tandem Mass Spectrometry with Post-Column Charge State Manipulation. Glycobiology. 2010; 20.
Naimy H, Staples G, Mccomb ME, Costello CE, Zaia J, Leymarie N. Patterns of Tissue-Specific Glycosaminoglycan Expression Revealed by Tandem Mass Spectrometry and Statistical Methods. Journal of biomolecular techniques: JBT. 2010; 21(3 Suppl).

Zaia J. On-line separations combined with MS for analysis of glycosaminoglycans. Mass Spectrom Rev. 2009 Mar-Apr; 28(2):254-72. PMID: 18956477; DOI: 10.1002/mas.20200;

Shi X, Zaia J. Organ-specific heparan sulfate structural phenotypes. J Biol Chem. 2009 May 1; 284(18):11806-14.View Related Profiles.

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PMID: 19244235; PMCID: PMC2673249; DOI: 10.1074/jbc.M809637200;

Staples GO, Bowman MJ, Costello CE, Hitchcock AM, Lau JM, Leymarie N, Miller C, Naimy H, Shi X, Zaia J. A chip-based amide-HILIC LC/MS platform for glycosaminoglycan glycomics profiling. Proteomics. 2009 Feb; 9(3):686-95.View Related Profiles.

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PMID: 19137549; PMCID: PMC2771417; DOI: 10.1002/pmic.200701008;

Zaia J, Shi X. Reply to Savolainen: Organ- and Cell-specific GAG Chains. Journal of Biological Chemistry. 2009; 284(18):le2. View Publication
Shi S, Staples G, Leymarie N, Naimy H, Zaia J. 36th American Chemical Society Northeast Regional Meeting. Glycomics of Heparan Sulfate. 2009.
Naimy H, Leymarie N, Zaia J. Annual Meeting of the Society-for-Glycobiology. Diagnostic Ions for Anticoagulant Heparan Sulfate Octasaccharides by Low Energy CID Tandem Mass Spectrometry. Glycobiology. 2009; 19.
Staples G, Zaia J. Annual Meeting of the Society-for-Glycobiology. Domain Structure Analysis of Heparan Sulfates by Mass Spectrometry. Glycobiology. 2009; 19.
Leymarie N, Staples G, Naimy H, Mccomb ME, Zaia J. Annual Meeting of the Society-for-Glycobiology. Tandem Mass Spectrometry and Statistical Methods: Tools Used to Differentiate, Characterize and Classify Tissues Specific Glycosaminoglycans. Glycobiology. 2009; 19.

Hitchcock AM, Bowman MJ, Staples GO, Zaia J. Improved workup for glycosaminoglycan disaccharide analysis using CE with LIF detection. Electrophoresis. 2008 Nov; 29(22):4538-48. PMID: 19035406; PMCID: PMC2810710; DOI: 10.1002/elps.200800335;

Zaia J. Mass spectrometry and the emerging field of glycomics. Chem Biol. 2008 Sep 22; 15(9):881-92. PMID: 18804025; PMCID: PMC2570164; DOI: 10.1016/j.chembiol.2008.07.016;

Hitchcock AM, Yates KE, Costello CE, Zaia J. Comparative glycomics of connective tissue glycosaminoglycans. Proteomics. 2008 Apr; 8(7):1384-97.View Related Profiles.

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PMID: 18318007; PMCID: PMC2577024; DOI: 10.1002/pmic.200700787;

Naimy H, Leymarie N, Bowman MJ, Zaia J. Characterization of heparin oligosaccharides binding specifically to antithrombin III using mass spectrometry. Biochemistry. 2008 Mar 11; 47(10):3155-61.View Related Profiles.

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PMID: 18260648; PMCID: PMC2716047; DOI: 10.1021/bi702043e;

Staples G, Leymarie N, Naimy H, Zaia J. Annual Meeting of the Society-for-Glycobiology. Informatics for Complex Glycan Mass Spectral Datasets. Glycobiology. 2008; 18.
Naimy H, Leymarie N, Zaia J. Annual Meeting of the Society-for-Glycobiology. Functional Characterization of Heparinoid Octasaccharide Libraries Using LC/MS. Glycobiology. 2008; 18.
Staples G, Costello CE, Zaia J. Annual Meeting of the Society-for-Glycobiology. Structural Analysis of Sulf2 Activity on Heparan Sulfate Domains. Glycobiology. 2008; 18.

Bowman MJ, Zaia J. Tags for the stable isotopic labeling of carbohydrates and quantitative analysis by mass spectrometry. Anal Chem. 2007 Aug 1; 79(15):5777-84. PMID: 17605469; PMCID: PMC2532755

Zaia J, Miller MJ, Seymour JL, Costello CE. The role of mobile protons in negative ion CID of oligosaccharides. J Am Soc Mass Spectrom. 2007 May; 18(5):952-60.View Related Profiles.

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Zaia, Joseph

PMID: 17383193; PMCID: PMC1964798

Hitchcock AM, Yates KE, Shortkroff S, Costello CE, Zaia J. Optimized extraction of glycosaminoglycans from normal and osteoarthritic cartilage for glycomics profiling. Glycobiology. 2007 Jan; 17(1):25-35.View Related Profiles.

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Zaia, Joseph

PMID: 16980326; PMCID: PMC2630472

Ziegler A, Zaia J. Size-exclusion chromatography of heparin oligosaccharides at high and low pressure. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6; 837(1-2):76-86. PMID: 16704936

Seymour JL, Costello CE, Zaia J. The influence of sialylation on glycan negative ion dissociation and energetics. J Am Soc Mass Spectrom. 2006 Jun; 17(6):844-54.View Related Profiles.

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Zaia, Joseph

PMID: 16603372; PMCID: PMC2586975

Hitchcock AM, Costello CE, Zaia J. Glycoform quantification of chondroitin/dermatan sulfate using a liquid chromatography-tandem mass spectrometry platform. Biochemistry. 2006 Feb 21; 45(7):2350-61.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 16475824; PMCID: PMC2597419

Miller MJ, Costello CE, Malmström A, Zaia J. A tandem mass spectrometric approach to determination of chondroitin/dermatan sulfate oligosaccharide glycoforms. Glycobiology. 2006 Jun; 16(6):502-13.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 16489125; PMCID: PMC2577607

Zaia J. In Ionization Methods; Gross ML, Caprioli RM, Eds. Elsevier. Amsterdam. 2006; 6:889-903.
Zaia J, Campuzano I, Giles K, Bateman R, Keith C, Costello CE. Meeting of the Society-for-Gylcobiology. Electrospray ion mobility spectrometry of isomeric carbohydrates. Glycobiology. 2006; 16.
Hitchcock AM, Costello CE, Zaia J. Meeting of the Society-for-Gylcobiology. Comparative glycomics of connective tissue glycosaminoglycans using mass spectrometry. Glycobiology. 2006; 16.
Zaia J, Seymour JL, Costello CE. Meeting of the Society-for-Glycobiology. Glycomics using negative ion tandem mass spectrometry of native glycans. Glycobiology. 2005; 15.
Hitchcock AM, Costello CE, Zaia J. Meeting of the Society-for-Glycobiology. An LC/MS/MS platform for glycoform quantification of chondroitin sulfate. Glycobiology. 2005; 15.
Zaia J. Principles of Mass Spectrometry of Glycosaminoglycans. Journal of Biomacromolecular Mass Spectrometry. 2005; 1:3-36.

Naggar EF, Costello CE, Zaia J. Competing fragmentation processes in tandem mass spectra of heparin-like glycosaminoglycans. J Am Soc Mass Spectrom. 2004 Nov; 15(11):1534-44.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 15519220

Zaia J. Mass spectrometry of oligosaccharides. Mass Spectrom Rev. 2004 May-Jun; 23(3):161-227. PMID: 14966796

Costello CE, Blackmun-Ross KE, Budnik BA, Elkin Y, Ivleva VB, Steen JA, Pittman JL, Xie B, Mccomb ME, O'Connor PB, Zaia J. Glycobiology. Sample preparation and mass spectral fragmentation methods for use in glycobiology. 2004.

Zaia J, Li XQ, Chan SY, Costello CE. Tandem mass spectrometric strategies for determination of sulfation positions and uronic acid epimerization in chondroitin sulfate oligosaccharides. J Am Soc Mass Spectrom. 2003 Nov; 14(11):1270-81.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 14597117

Zaia J, Costello CE. Tandem mass spectrometry of sulfated heparin-like glycosaminoglycan oligosaccharides. Anal Chem. 2003 May 15; 75(10):2445-55.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 12918989

Naggar EF, Costello CE, Zaia J. 8th Annual Conference of the Society-for-Glycobiology. Identification and sequencing of protein binding heparin-like glycosaminoglycan oligosaccharides. Glycobiology. 2003; 13.
Costello CE, Mccomb ME, O'Connor PB, Zaia J. 8th Annual Conference of the Society-for-Glycobiology. Mass spectrometry-based methods for revealing the Glyeans' family secrets. Gylcobiology. 2003; 13.

McClellan JE, Costello CE, O'Connor PB, Zaia J. Influence of charge state on product ion mass spectra and the determination of 4S/6S sulfation sequence of chondroitin sulfate oligosaccharides. Anal Chem. 2002 Aug 1; 74(15):3760-71.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 12175164

Zaia J, Costello CE. 7th Annual Conference of the Society-for-Glycobiology. A new approach for sequencing heparins. Glycobiology. 2002; 12.

Zaia J, McClellan JE, Costello CE. Tandem mass spectrometric determination of the 4S/6S sulfation sequence in chondroitin sulfate oligosaccharides. Anal Chem. 2001 Dec 15; 73(24):6030-9.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 11791576

Barry F, Boynton R, Murphy M, Haynesworth S, Zaia J. The SH-3 and SH-4 antibodies recognize distinct epitopes on CD73 from human mesenchymal stem cells. Biochem Biophys Res Commun. 2001 Nov 30; 289(2):519-24. PMID: 11716504

Zaia J, Boynton R, Heinegård D, Barry F. Posttranslational modifications to human bone sialoprotein determined by mass spectrometry. Biochemistry. 2001 Oct 30; 40(43):12983-91. PMID: 11669636

Zaia J, Costello CE. Compositional analysis of glycosaminoglycans by electrospray mass spectrometry. Anal Chem. 2001 Jan 15; 73(2):233-9.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 11199971

Cheng X, Cole RN, Zaia J, Hart GW. Alternative O-glycosylation/O-phosphorylation of the murine estrogen receptor beta. Biochemistry. 2000 Sep 26; 39(38):11609-20. PMID: 10995228

Zaia J, Liu B, Boynton R, Barry F. Structural analysis of cartilage proteoglycans and glycoproteins using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem. 2000 Jan 1; 277(1):94-103. PMID: 10610693

Zaia J, Costello CE. Characterization of glycosaminoglycan structure using mass spectrometry. Glycobiology. 2000; 10(10):1093.

Barry FP, Boynton RE, Haynesworth S, Murphy JM, Zaia J. The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105). Biochem Biophys Res Commun. 1999 Nov; 265(1):134-9. PMID: 10548503

Fenselau C, Antoine MD, Fabris D, Hathout Y, He T, Zaia J. In Metallothionein IV; Klaasen C, Ed. Birkhauser. Basel. 1999; 577-580.
Fenselau C, Antoine MD, Fabris D, Hathout Y, He T, Zaia J. Metallothionein IV. A chemical mechanism for inactivation of anticancer drugs by metallothionein. 1999; 577-580. View Publication

Zaia J, Fabris D, Wei D, Karpel RL, Fenselau C. Monitoring metal ion flux in reactions of metallothionein and drug-modified metallothionein by electrospray mass spectrometry. Protein Sci. 1998 Nov; 7(11):2398-404. PMID: 9828006; PMCID: PMC2143854

van den Bos C, Rammes A, Vogl T, Boynton R, Zaia J, Sorg C, Roth J. Copurification of P6, MRP8, and MRP14 from human granulocytes and separation of individual proteins. Protein Expr Purif. 1998 Aug; 13(3):313-8. PMID: 9693055

Bruder SP, Ricalton NS, Boynton RE, Connolly TJ, Jaiswal N, Zaia J, Barry FP. Mesenchymal stem cell surface antigen SB-10 corresponds to activated leukocyte cell adhesion molecule and is involved in osteogenic differentiation. J Bone Miner Res. 1998 Apr; 13(4):655-63. PMID: 9556065

Zaia J, Boynton RE, McIntosh A, Marshak DR, Olsson H, Heinegârd D, Barry FP. Post-translational modifications in cartilage oligomeric matrix protein. Characterization of the N-linked oligosaccharides by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. J Biol Chem. 1997 May 30; 272(22):14120-6. PMID: 9162039

Zaia J, Jiang L, Han MS, Tabb JR, Wu Z, Fabris D, Fenselau C. A binding site for chlorambucil on metallothionein. Biochemistry. 1996 Mar 5; 35(9):2830-5. PMID: 8608118

Zaia J. Charged derivatives for peptide sequencing using a magnetic sector instrument. Methods Mol Biol. 1996; 61:29-41. PMID: 8930863

Fabris D, Zaia J, Hathout Y, Fenselau C. Retention of thiol protons in two classes of protein zinc ion coordination centers. J Am Chem Soc. 1996; 118:12242-12243. View Publication
Zaia J, Boynton R, Heinegard D, Barry F. Patterns of glycosylation in cartilage oligomeric matrix protein measured by monosaccharide composition analysis, MALDI/TOF and electrospray mass spectrometry. Glycobiology. 1996; 6(7):115.
Zaia J, Biemann K. Comparison of charged derivatives for high energy collision-induced dissociation tandem mass spectrometry. J Am Soc Mass Spectrom. 1995; 6(5):428-436. View Publication

Day BW, Skipper PL, Zaia J, Singh K, Tannenbaum SR. Enantiospecificity of covalent adduct formation by benzo[a]pyrene anti-diol epoxide with human serum albumin. Chem Res Toxicol. 1994 Nov-Dec; 7(6):829-35. PMID: 7696539

Zaia J, Biemann K. Characteristics of high energy collision-induced dissociation tandem mass spectra of polycyclic aromatic hydrocarbon diolepoxide adducted peptides. J Am Soc Mass Spectrom. 1994; 5(7):649-654. View Publication
Zaia J, Biemann K. Proteinase K activity inhibited near amino acids carrying large substituents: three PAH diolepoxides covalently modify His-146 human serum albumin residues. J Am Chem Soc. 1994; 116:7407-7408. View Publication

Zaia J, Annan RS, Biemann K. The correct molecular weight of myoglobin, a common calibrant for mass spectrometry. Rapid Commun Mass Spectrom. 1992 Jan; 6(1):32-6. PMID: 1591398

Day BW, Skipper PL, Zaia J, Tannenbaum SR. Benzo[a]pyrene anti-diol epoxide covalently modifies human serum albumin carboxylate side chains and imidazole side chains of histidine(146). J Am Chem Soc. 1991; 113:8505-8509. View Publication

Nicholson-Weller A, Zaia J, Raum MG, Coligan JE. Decay accelerating factor (DAF) peptide sequences share homology with a consensus sequence found in the superfamily of structurally related complement proteins and other proteins including haptoglobin, factor XIII, beta 2-glycoprotein I, and the IL-2 receptor. Immunol Lett. 1987 Apr; 14(4):307-11. PMID: 2438213

Wenzel TJ, Zaia J. Organic-Soluble Lanthanide Nuclear-Magnetic-Resonance Shift-Reagents for Sulfonium and Isothiouronium Salts. Anal Chem. 1987; 59:562-567. View Publication
Wenzel TJ, Zaia J. Lanthanide Tetrakis (Beta-Diketonates) as Effective NMR Shift-Reagents for Organic Salts. J Org Chem. 1985; 50:1322-1324. View Publication

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 186 publications over 31 distinct years, with a maximum of 22 publications in 2011

Bar chart showing 186 publications over 31 distinct years, with a maximum of 22 publications in 2011

Year	Publications
1985	1
1987	2
1991	1
1992	1
1994	3
1995	1
1996	4
1997	1
1998	3
1999	3
2000	3
2001	4
2002	2
2003	4
2004	3
2005	3
2006	8
2007	2
2008	7
2009	8
2010	11
2011	22
2012	11
2013	16
2014	10
2015	8
2016	10
2017	5
2018	11
2019	11
2020	7

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

glycomics
glycosaminoglycan
heparan sulfate
heparin
mass spectrometry
proteoglycan

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