Joseph Zaia | Profiles RNS

Joseph Zaia, PhD

Professor

Boston University School of Medicine

Dept of Biochemistry

PhD, Massachusetts Institute of Technology

Websites

	Biochemistry Faculty
	Center for Biomedical Mass Spectrometry
	Proteoglycan and Glycosaminoglycan Structure Laboratory
	Google Scholar
	ResearchGate
	LinkedIn

ORCID : 0000-0001-9497-8701

The manner in which a cell responds to many growth factor stimuli depends on interactions between glycosaminoglycans (GAGs), growth factors, and growth factor receptors. Extracellular matrix GAGs binds growth factors, creating morphogens gradients essential to tissue patterning. Because these events depend on the fine structure of the GAG chains present, regulation of GAG biosynthesis is a key factor for understanding normal and disease related cellular growth
The key to exploiting an understanding of GAG structure-function relationships for human disease therapy is to winnow oligosaccharide-protein binding patterns from heterogeneous biological preparations. Toward this end, we have developed mass spectral methods for GAGs that enable comparison of structures as a function of biological variables.

The long term research aims are (1) to develop a fundamental understanding of the manner in which glycosaminoglycan expression is varied according to the cellular growth environment related to human disease and (2) to identify HS chain structures useful as therapeutic targets.

New bioinformatics methods are essential to realizing these goals. The data produced using our methods are information rich and not amenable to manual interpretation. Further, the methods needed are distinct from those used in genomics and proteomics. We are developing bioinformatics methods appropriate for interpretation of structural data on glycosaminoglycans and other carbohydrates to identify targets for disease therapy.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

Member
Boston University
Bioinformatics Graduate Program

Center Faculty Member
Boston University School of Medicine
Mass Spectrometry

BU Sponsored Research
NIH RePORTER Sponsored Research

Glycomics and proteomics of brain specimens
03/15/2018 - 12/31/2022 (PI)
The Scripps Research Institute NIH NIDA
1R01DA046170-01

An open-source software suite for processing glycomics and glycoproteomics mass spectral data
08/14/2017 - 07/31/2020 (PI)
NIH/National Cancer Institute
1U01CA221234-01

Proteomic and glycomic analysis of human brain and lung cancers
07/01/2016 - 06/30/2018 (PI)
The Regents of the University of California, San Francisco NIH NCI
4U01CA168878-05

Software for Automated Interpretation of Heparan Sulfate Tandem Mass Spectra
09/15/2015 - 06/30/2018 (PI)
NIH/National Heart, Lung, and Blood Institute
3R21HL131554-02S1

Thalamic Axonal Pathways and Extracellular Matrix Abnormalities in Schizophrenia
09/01/2015 - 06/30/2018 (PI)
McLean Hospital Corporation NIH NIMH
5R01MH105608-03

Quantitative Profiling of Glycosaminoglycans from Breast Tumor Tissue Arrays
07/09/2014 - 06/30/2018 (PI)
NIH/National Cancer Institute
5R21CA177479-03

Viral Vector Transduction Deficiencies in the Aged Nigrostriatal System
09/30/2016 - 06/30/2017 (PI)
Michigan State University NIH NIA
1R56AG052328-01A1

Quantitative glycomics and proteomics combined with laser capture microdissection
06/01/2013 - 05/21/2017 (PI)
Agilent Technologies, Inc.

A Thermo-Fisher Scientific Q-Exactive HF Mass Spectrometry System
05/01/2016 - 04/30/2017 (PI)
NIH/Office of the Director
1S10OD021651-01

Extracellular Sulfatases As Novel Biomarkers for Early Detection of Cancer
07/01/2015 - 06/30/2016 (PI)
The Regents of the University of California, San Francisco NIH NCI
5U01CA168878-04

Showing 10 of 19 results. Show All Results

Yr	Title	Project-Sub Proj	Pubs
2017	An open-source software suite for processing glycomics and glycoproteomics mass spectral data	1U01CA221234-01
2016	A Thermo-Fisher Scientific Q-Exactive HF Mass Spectrometry System	1S10OD021651-01	1
2016	Software for automated interpretation of heparan sulfate tandem mass spectra	5R21HL131554-02	2
2016	Software for automated interpretation of heparan sulfate tandem mass spectra	3R21HL131554-02S1	2
2016	Quantitative profiling of glycosaminoglycans from breast tumor tissue arrays	5R21CA177479-03	1
2015	Software for automated interpretation of heparan sulfate tandem mass spectra	1R21HL131554-01	2
2014	Quantitative profiling of glycosaminoglycans from breast tumor tissue arrays	1R21CA177479-01A1	1
2014	Quantitative profiling of glycosaminoglycans from breast tumor tissue arrays	1R21CA177479-01A1	1
2013	Post-biosynthetic Remodeling of Heparan Sulfate	5R01HL098950-04	27
2012	Post-biosynthetic Remodeling of Heparan Sulfate	5R01HL098950-03	27

Showing 10 of 130 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Raghunathan R, Polinski NK, Klein JA, Hogan JD, Shao C, Khatri K, Leon DR, McComb ME, Manfredsson FP, Sortwell CE, Zaia J. Glycomic and Proteomic changes in aging brain nigrostriatal pathway. Mol Cell Proteomics. 2018 Jun 18.View Related Profiles.

Zaia, Joseph
Khatri, Kshitij
McComb, Mark
Raghunathan, Rekha

PMID: 29915149; DOI: 10.1074/mcp.RA118.000680;.

Zaia J, Bierbaum VM. Focus on Mass Spectrometry in Glycobiology and Related Fields, Honoring Catherine E. Costello, Recipient of the 2017 ASMS Award for a Distinguished Contribution in Mass Spectrometry. J Am Soc Mass Spectrom. 2018 Jun; 29(6):1061-1064. PMID: 29855889.

Klein J, Carvalho L, Zaia J. Application of Network Smoothing to Glycan LC-MS Profiling. Bioinformatics. 2018 May 22. PMID: 29790907.

Klein JA, Meng L, Zaia J. Deep Sequencing of Complex Proteoglycans: A Novel Strategy for High Coverage and Site-specific Identification of Glycosaminoglycan-linked Peptides. Mol Cell Proteomics. 2018 Aug; 17(8):1578-1590. PMID: 29773674.

van Eijk M, Rynkiewicz MJ, Khatri K, Leymarie N, Zaia J, White MR, Hartshorn KL, Cafarella TR, van Die I, Hessing M, Seaton BA, Haagsman HP. Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus. J Biol Chem. 2018 Jul 06; 293(27):10646-10662.View Related Profiles.

Seaton, Barbara
Zaia, Joseph
Hartshorn, Kevan
Khatri, Kshitij
Rynkiewicz, Michael
Leymarie, Nancy

PMID: 29769321.

Khatri K, Pu Y, Klein JA, Wei J, Costello CE, Lin C, Zaia J. Comparison of Collisional and Electron-Based Dissociation Modes for Middle-Down Analysis of Multiply Glycosylated Peptides. J Am Soc Mass Spectrom. 2018 Jun; 29(6):1075-1085.View Related Profiles.

Costello, Catherine
Zaia, Joseph
Khatri, Kshitij

PMID: 29663256.

Hogan JD, Klein JA, Wu J, Chopra P, Boons GJ, Carvalho L, Lin C, Zaia J. Software for Peak Finding and Elemental Composition Assignment for Glycosaminoglycan Tandem Mass Spectra. Mol Cell Proteomics. 2018 Jul; 17(7):1448-1456. PMID: 29615495.

Wu J, Wei J, Hogan JD, Chopra P, Joshi A, Lu W, Klein J, Boons GJ, Lin C, Zaia J. Negative Electron Transfer Dissociation Sequencing of 3-O-Sulfation-Containing Heparan Sulfate Oligosaccharides. J Am Soc Mass Spectrom. 2018 Jun; 29(6):1262-1272. PMID: 29564812.

Turiák L, Tóth G, Ozohanics O, Révész Á, Ács A, Vékey K, Zaia J, Drahos L. Sensitive method for glycosaminoglycan analysis of tissue sections. J Chromatogr A. 2018 Apr 06; 1544:41-48.View Related Profiles.

Zaia, Joseph
Turiak, Lilla

PMID: 29506752.

Wu ZL, Person AD, Anderson M, Burroughs B, Tatge T, Khatri K, Zou Y, Wang L, Geders T, Zaia J, Sackstein R. Imaging specific cellular glycan structures using glycosyltransferases via click chemistry. Glycobiology. 2018 02 01; 28(2):69-79.View Related Profiles.

Zaia, Joseph
Khatri, Kshitij

PMID: 29186441.

Showing 10 of 167 results. Show More

Chen J, Kawamura T, Sethi MK, Zaia J, Repunte-Canonigo V, Sanna PP. Heparan sulfate: Resilience factor and therapeutic target for cocaine abuse. Sci Rep. 2017 Oct 24; 7(1):13931. PMID: 29066725.

Khatri K, Klein JA, Haserick JR, Leon DR, Costello CE, McComb ME, Zaia J. Microfluidic Capillary Electrophoresis-Mass Spectrometry for Analysis of Monosaccharides, Oligosaccharides, and Glycopeptides. Anal Chem. 2017 Jun 20; 89(12):6645-6655.View Related Profiles.

Costello, Catherine
Haserick, John
Zaia, Joseph
Khatri, Kshitij
McComb, Mark

PMID: 28530388.

Wu ZL, Huang X, Ethen CM, Tatge T, Pasek M, Zaia J. Non-reducing end labeling of heparan sulfate via click chemistry and a high throughput ELISA assay for heparanase. Glycobiology. 2017 Jun 01; 27(6):518-524. PMID: 28025251; DOI: 10.1093/glycob/cww130;.

Glaskin RS, Khatri K, Wang Q, Zaia J, Costello CE. Construction of a Database of Collision Cross Section Values for Glycopeptides, Glycans, and Peptides Determined by IM-MS. Anal Chem. 2017 Apr 18; 89(8):4452-4460.View Related Profiles.

Costello, Catherine
Zaia, Joseph
Khatri, Kshitij
Wang, Qi
Glaskin, Rebecca

PMID: 28323417; DOI: 10.1021/acs.analchem.6b04146;.

Wu ZL, Huang X, Ethen CM, Tatge T, Pasek M, Zaia J. Non-reducing end labeling of heparan sulfate via click chemistry and a high throughput ELISA assay for heparanase. Glycobiology. 2017 Feb 06; 1-7. PMID: 28173134; DOI: 10.1093/glycob/cww130;.

Liu Y, McBride R, Stoll M, Palma AS, Silva L, Agravat S, Aoki-Kinoshita KF, Campbell MP, Costello CE, Dell A, Haslam SM, Karlsson NG, Khoo KH, Kolarich D, Novotny MV, Packer NH, Ranzinger R, Rapp E, Rudd PM, Struwe WB, Tiemeyer M, Wells L, York WS, Zaia J, Kettner C, Paulson JC, Feizi T, Smith DF. The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting glycan microarray-based data. Glycobiology. 2016 Nov 22.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 27993942.

Zaia J, Khatri K, Klein J, Shao C, Sheng Y, Viner R. Complete Molecular Weight Profiling of Low-Molecular Weight Heparins Using Size Exclusion Chromatography-Ion Suppressor-High-Resolution Mass Spectrometry. Anal Chem. 2016 11 01; 88(21):10654-10660.View Related Profiles.

Shao, Chun
Zaia, Joseph
Khatri, Kshitij

PMID: 27709905.

Khatri K, Klein JA, Zaia J. Use of an informed search space maximizes confidence of site-specific assignment of glycoprotein glycosylation. Anal Bioanal Chem. 2017 Jan; 409(2):607-618.View Related Profiles.

Zaia, Joseph
Khatri, Kshitij

PMID: 27734143; DOI: 10.1007/s00216-016-9970-5;.

Dierker T, Shao C, Haitina T, Zaia J, Hinas A, Kjellén L. Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans. Sci Rep. 2016 10 05; 6:34662. PMID: 27703236; DOI: 10.1038/srep34662;.

Struwe WB, Agravat S, Aoki-Kinoshita KF, Campbell MP, Costello CE, Dell A, Ten Feizi, Haslam SM, Karlsson NG, Khoo KH, Kolarich D, Liu Y, McBride R, Novotny MV, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Tiemeyer M, Wells L, York WS, Zaia J, Kettner C. The minimum information required for a glycomics experiment (MIRAGE) project: sample preparation guidelines for reliable reporting of glycomics datasets. Glycobiology. 2016 Sep; 26(9):907-910.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 27654115.

Sethi MK, Zaia J. Extracellular matrix proteomics in schizophrenia and Alzheimer's disease. Anal Bioanal Chem. 2017 Jan; 409(2):379-394. PMID: 27601046; DOI: 10.1007/s00216-016-9900-6;.

He H, Liu D, Lin H, Jiang S, Ying Y, Chun S, Deng H, Zaia J, Wen R, Luo Z. Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein and has multiple functions. Biochim Biophys Acta. 2016 Jul; 1863(7 Pt A):1682-9.View Related Profiles.

Zaia, Joseph
Luo, Zhijun

PMID: 27033522; DOI: 10.1016/j.bbamcr.2016.03.022;.

Khatri K, Klein JA, White MR, Grant OC, Leymarie N, Woods RJ, Hartshorn KL, Zaia J. Integrated Omics and Computational Glycobiology Reveal Structural Basis for Influenza A Virus Glycan Microheterogeneity and Host Interactions. Mol Cell Proteomics. 2016 Jun; 15(6):1895-912.View Related Profiles.

Zaia, Joseph
Hartshorn, Kevan
Khatri, Kshitij
Leymarie, Nancy

PMID: 26984886; DOI: 10.1074/mcp.M116.058016;.

Hu H, Khatri K, Zaia J. Algorithms and design strategies towards automated glycoproteomics analysis. Mass Spectrom Rev. 2017 Jul; 36(4):475-498.View Related Profiles.

Zaia, Joseph
Khatri, Kshitij

PMID: 26728195; DOI: 10.1002/mas.21487;.

Hu H, Mao Y, Huang Y, Lin C, Zaia J. Bioinformatics of glycosaminoglycans. Perspectives in Science. 2016; 11(C). View Publication

Tykesson E, Mao Y, Maccarana M, Pu Y, Gao J, Lin C, Zaia J, Westergren-Thorsson G, Ellervik U, Malmström L, Malmström A. Deciphering the Mode of Action of the Processive Polysaccharide Modifying Enzyme Dermatan Sulfate Epimerase 1 by Hydrogen-Deuterium Exchange Mass Spectrometry. Chem Sci. 2016 Feb 01; 7(2):1447-1456.View Related Profiles.

Lin, Cheng
Zaia, Joseph

PMID: 26900446.

Hu H, Khatri K, Klein J, Leymarie N, Zaia J. A review of methods for interpretation of glycopeptide tandem mass spectral data. Glycoconj J. 2016 Jun; 33(3):285-96.View Related Profiles.

Zaia, Joseph
Khatri, Kshitij
Leymarie, Nancy

PMID: 26612686; PMCID: PMC4882288; DOI: 10.1007/s10719-015-9633-3;.

Aoki-Kinoshita K, Agravat S, Aoki NP, Arpinar S, Cummings RD, Fujita A, Fujita N, Hart GM, Haslam SM, Kawasaki T, Matsubara M, Moreman KW, Okuda S, Pierce M, Ranzinger R, Shikanai T, Shinmachi D, Solovieva E, Suzuki Y, Tsuchiya S, Yamada I, York WS, Zaia J, Narimatsu H. GlyTouCan 1.0--The international glycan structure repository. Nucleic Acids Res. 2016 Jan 4; 44(D1):D1237-42. PMID: 26476458; PMCID: PMC4702779; DOI: 10.1093/nar/gkv1041;.

Salanti A, Clausen TM, Agerbæk MØ, Al Nakouzi N, Dahlbäck M, Oo HZ, Lee S, Gustavsson T, Rich JR, Hedberg BJ, Mao Y, Barington L, Pereira MA, LoBello J, Endo M, Fazli L, Soden J, Wang CK, Sander AF, Dagil R, Thrane S, Holst PJ, Meng L, Favero F, Weiss GJ, Nielsen MA, Freeth J, Nielsen TO, Zaia J, Tran NL, Trent J, Babcook JS, Theander TG, Sorensen PH, Daugaard M. Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein. Cancer Cell. 2015 Oct 12; 28(4):500-14.View Related Profiles.

Zaia, Joseph
Mao, Yang

PMID: 26461094; PMCID: PMC4790448; DOI: 10.1016/j.ccell.2015.09.003;.

Aoki NP, Aoki-Kinoshita KF, Agravat S, Zaia J et. al. Annual Meeting of the Society-for-Glycobiology on Glycobiology. The Official Release of the International Glycan Structure Repository. Glycobiology. 2015.

Zaia J, Klein J, Khatri K, Yip S. GlyrReSoft: A tool for assigning sites specific glycoprotein glycosylation from integrated omics data using rigorous statistics. Annual Meeting of the Society-for-Glycobiology on Glycobiology. 2015.

Shao C, Klein J, Turiak L, Phillips J, Zaia J. Annual Meeting of the Society-for-Glycobiology on Glycobiology. Dysregulation of proteoglycan expression in astrocytoma: assessment using an integrated omics approach. Glycobiology. 2015.

Khatri K, Klein J, White MR, Grant OC, Leymarie N, Woods RJ, Hartshorn KL, Zaia J. Annual Meeting of the Society-for-Glycobiology on Glycobiology. Understanding glycan mediated interactions of the Influenza A virus with host immune system using integrated omics and computational glycobiology. Glycobiology. 2015; 25.

Huang Y, Mao Y, Zong C, Lin C, Boons GJ, Zaia J. Discovery of a heparan sulfate 3-O-sulfation specific peeling reaction. Anal Chem. 2015 Jan 6; 87(1):592-600.View Related Profiles.

Lin, Cheng
Zaia, Joseph
Mao, Yang
Huang, Yu

PMID: 25486437; PMCID: PMC4287833; DOI: 10.1021/ac503248k;.

Reine TM, Kolseth IB, Meen AJ, Lindahl JP, Jenssen TG, Reinholt FP, Zaia J, Shao C, Hartmann A, Kolset SO. Effects of restoring normoglycemia in type 1 diabetes on inflammatory profile and renal extracellular matrix structure after simultaneous pancreas and kidney transplantation. Diabetes Res Clin Pract. 2015 Jan; 107(1):46-53. PMID: 25467621; PMCID: PMC4324617; DOI: 10.1016/j.diabres.2014.10.006;.

Mao Y, Huang Y, Buczek-Thomas JA, Ethen CM, Nugent MA, Wu ZL, Zaia J. A liquid chromatography-mass spectrometry-based approach to characterize the substrate specificity of mammalian heparanase. J Biol Chem. 2014 Dec 5; 289(49):34141-51.View Related Profiles.

Zaia, Joseph
Nugent, Matthew
Mao, Yang
Huang, Yu

PMID: 25336655; PMCID: PMC4256347; DOI: 10.1074/jbc.M114.589630;.

Turiák L, Shao C, Meng L, Khatri K, Leymarie N, Wang Q, Pantazopoulos H, Leon DR, Zaia J. Workflow for combined proteomics and glycomics profiling from histological tissues. Anal Chem. 2014 Oct 7; 86(19):9670-8.View Related Profiles.

Shao, Chun
Zaia, Joseph
Khatri, Kshitij
Turiak, Lilla
Leymarie, Nancy
Wang, Qi

PMID: 25203838; PMCID: PMC4427244; DOI: 10.1021/ac5022216;.

Khatri K, Staples GO, Leymarie N, Leon DR, Turiák L, Huang Y, Yip S, Hu H, Heckendorf CF, Zaia J. Confident assignment of site-specific glycosylation in complex glycoproteins in a single step. J Proteome Res. 2014 Oct 3; 13(10):4347-55.View Related Profiles.

Zaia, Joseph
Khatri, Kshitij
Turiak, Lilla
Leymarie, Nancy
Huang, Yu

PMID: 25153361; PMCID: PMC4184449; DOI: 10.1021/pr500506z;.

Huang Y, Mao Y, Buczek-Thomas JA, Nugent MA, Zaia J. Oligosaccharide substrate preferences of human extracellular sulfatase Sulf2 using liquid chromatography-mass spectrometry based glycomics approaches. PLoS One. 2014; 9(8):e105143.View Related Profiles.

Zaia, Joseph
Nugent, Matthew
Mao, Yang
Huang, Yu

PMID: 25127119; PMCID: PMC4134258; DOI: 10.1371/journal.pone.0105143;.

Hu H, Huang Y, Mao Y, Yu X, Xu Y, Liu J, Zong C, Boons GJ, Lin C, Xia Y, Zaia J. A computational framework for heparan sulfate sequencing using high-resolution tandem mass spectra. Mol Cell Proteomics. 2014 Sep; 13(9):2490-502.View Related Profiles.

Lin, Cheng
Zaia, Joseph
Mao, Yang
Huang, Yu

PMID: 24925905; PMCID: PMC4159664; DOI: 10.1074/mcp.M114.039560;.

Wu ZL, Robey MT, Tatge T, Lin C, Leymarie N, Zou Y, Zaia J. Detecting O-GlcNAc using in vitro sulfation. Glycobiology. 2014 Aug; 24(8):740-7.View Related Profiles.

Lin, Cheng
Zaia, Joseph
Leymarie, Nancy

PMID: 24799377; PMCID: PMC4070980; DOI: 10.1093/glycob/cwu037;.

York WS, Agravat S, Aoki-Kinoshita KF, McBride R, Campbell MP, Costello CE, Dell A, Feizi T, Haslam SM, Karlsson N, Khoo KH, Kolarich D, Liu Y, Novotny M, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Struwe WB, Tiemeyer M, Wells L, Zaia J, Kettner C. MIRAGE: the minimum information required for a glycomics experiment. Glycobiology. 2014 May; 24(5):402-6.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 24653214; PMCID: PMC3976285; DOI: 10.1093/glycob/cwu018;.

Aoki-Kinoshita KF, Agravat S, Aoki NP, Zaia J et. al. Joint Meeting of the Society-for-Glycobiology (SFG). Development of an International Glycan Structure Repository. Glycobiology. 2014; 24.

Hu H, Dittwald P, Zaia J, Valkenborg D. Comment on "Computation of isotopic peak center-mass distribution by fourier transform". Anal Chem. 2013 Dec 17; 85(24):12189-92. PMID: 24187947; PMCID: PMC4119064; DOI: 10.1021/ac402731h;.

Huang Y, Yu X, Mao Y, Costello CE, Zaia J, Lin C. De novo sequencing of heparan sulfate oligosaccharides by electron-activated dissociation. Anal Chem. 2013 Dec 17; 85(24):11979-86.View Related Profiles.

Costello, Catherine
Lin, Cheng
Zaia, Joseph
Mao, Yang
Huang, Yu

PMID: 24224699; PMCID: PMC3912864; DOI: 10.1021/ac402931j;.

Mathias DK, Pastrana-Mena R, Ranucci E, Tao D, Ferruti P, Ortega C, Staples GO, Zaia J, Takashima E, Tsuboi T, Borg NA, Verotta L, Dinglasan RR. A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut. PLoS Pathog. 2013; 9(11):e1003757. PMID: 24278017; PMCID: PMC3836724; DOI: 10.1371/journal.ppat.1003757;.

Ramachandra R, Namburi RB, Ortega-Martinez O, Shi X, Zaia J, Dupont ST, Thorndyke MC, Lindahl U, Spillmann D. Brittlestars contain highly sulfated chondroitin sulfates/dermatan sulfates that promote fibroblast growth factor 2-induced cell signaling. Glycobiology. 2014 Feb; 24(2):195-207. PMID: 24253764; PMCID: PMC3907082; DOI: 10.1093/glycob/cwt100;.

Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide. Immunology. 2013 Nov; 140(3):374-89.View Related Profiles.

Seaton, Barbara
Costello, Catherine
Madico, Guillermo
Sharon, Jacqueline
Zaia, Joseph
Rynkiewicz, Michael
Wang, Qi
Lu, Zhaohua

PMID: 23844703; PMCID: PMC3800442; DOI: 10.1111/imm.12150;.

Shao C, Shi X, Phillips JJ, Zaia J. Mass spectral profiling of glycosaminoglycans from histological tissue surfaces. Anal Chem. 2013 Nov 19; 85(22):10984-91.View Related Profiles.

Shao, Chun
Zaia, Joseph
Shi, Xiaofeng

PMID: 24099043; PMCID: PMC3872031; DOI: 10.1021/ac402517s;.

Nugent MA, Zaia J, Spencer JL. Heparan sulfate-protein binding specificity. Biochemistry (Mosc). 2013 Jul; 78(7):726-35.View Related Profiles.

Spencer, Jean
Zaia, Joseph
Nugent, Matthew

PMID: 24010836; PMCID: PMC4108213; DOI: 10.1134/S0006297913070055;.

Leymarie N, Griffin PJ, Jonscher K, Kolarich D, Orlando R, McComb M, Zaia J, Aguilan J, Alley WR, Altmann F, Ball LE, Basumallick L, Bazemore-Walker CR, Behnken H, Blank MA, Brown KJ, Bunz SC, Cairo CW, Cipollo JF, Daneshfar R, Desaire H, Drake RR, Go EP, Goldman R, Gruber C, Halim A, Hathout Y, Hensbergen PJ, Horn DM, Hurum D, Jabs W, Larson G, Ly M, Mann BF, Marx K, Mechref Y, Meyer B, Möginger U, Neusüß C, Nilsson J, Novotny MV, Nyalwidhe JO, Packer NH, Pompach P, Reiz B, Resemann A, Rohrer JS, Ruthenbeck A, Sanda M, Schulz JM, Schweiger-Hufnagel U, Sihlbom C, Song E, Staples GO, Suckau D, Tang H, Thaysen-Andersen M, Viner RI, An Y, Valmu L, Wada Y, Watson M, Windwarder M, Whittal R, Wuhrer M, Zhu Y, Zou C. Interlaboratory study on differential analysis of protein glycosylation by mass spectrometry: the ABRF glycoprotein research multi-institutional study 2012. Mol Cell Proteomics. 2013 Oct; 12(10):2935-51.View Related Profiles.

Zaia, Joseph
McComb, Mark
Leymarie, Nancy

PMID: 23764502; PMCID: PMC3790302; DOI: 10.1074/mcp.M113.030643;.

Shi X, Shao C, Mao Y, Huang Y, Wu ZL, Zaia J. LC-MS and LC-MS/MS studies of incorporation of 34SO3 into glycosaminoglycan chains by sulfotransferases. Glycobiology. 2013 Aug; 23(8):969-79.View Related Profiles.

Shao, Chun
Zaia, Joseph
Shi, Xiaofeng
Mao, Yang
Huang, Yu

PMID: 23696150; PMCID: PMC3695753; DOI: 10.1093/glycob/cwt033;.

Shao C, Shi X, White M, Huang Y, Hartshorn K, Zaia J. Comparative glycomics of leukocyte glycosaminoglycans. FEBS J. 2013 May; 280(10):2447-61.View Related Profiles.

Shao, Chun
Zaia, Joseph
Hartshorn, Kevan
Shi, Xiaofeng
Huang, Yu

PMID: 23480678; PMCID: PMC3651794; DOI: 10.1111/febs.12231;.

Kolarich D, Rapp E, Struwe WB, Haslam SM, Zaia J, McBride R, Agravat S, Campbell MP, Kato M, Ranzinger R, Kettner C, York WS. The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting mass-spectrometry-based glycoanalytic data. Mol Cell Proteomics. 2013 Apr; 12(4):991-5. PMID: 23378518; PMCID: PMC3617344; DOI: 10.1074/mcp.O112.026492;.

Zaia J. Glycosaminoglycan glycomics using mass spectrometry. Mol Cell Proteomics. 2013 Apr; 12(4):885-92. PMID: 23325770; PMCID: PMC3617335; DOI: 10.1074/mcp.R112.026294;.

Gill VL, Aich U, Rao S, Pohl C, Zaia J. Disaccharide analysis of glycosaminoglycans using hydrophilic interaction chromatography and mass spectrometry. Anal Chem. 2013 Jan 15; 85(2):1138-45. PMID: 23234263; PMCID: PMC3557806; DOI: 10.1021/ac3030448;.

Zaia J. Capillary electrophoresis-mass spectrometry of carbohydrates. Methods Mol Biol. 2013; 984:13-25. PMID: 23386333; DOI: 10.1007/978-1-62703-296-4_2;.

Leymarie N, Griffin PJ, Xing C, Jonscher K, Kolarich D, Orlando R. Mccomb ME, Zaia J. 61st ASMS Conference on Mass Spectrometry and Allied Topics. Ability of the glycoproteomics comminuty to profile N-glycosylation of prostate specific antigen by mass spectrometry: an ABRF 2013 Interlaboratory Study. 2013.

Thaysen-Andersen M, Suckau D, Jonscher K, Kolarich D, Orlando R, Mccomb ME, Zaia J, Neymarie N. Glycoprotein Research Group (gPRG) 2013 Interlaboratory Study: Quantitative N-glycan Profiling of Prostate Specific Antigen. Journal of biomolecular techniques: JBT. 2013; 24(Suppl):S71.

Maxwell E, Tan Y, Tan Y, Hu H, Benson G, Aizikov K, Conley S, Staples GO, Slysz GW, Smith RD, Zaia J. GlycReSoft: a software package for automated recognition of glycans from LC/MS data. PLoS One. 2012; 7(9):e45474.View Related Profiles.

Zaia, Joseph
Aizikov, Konstantin

PMID: 23049804; PMCID: PMC3458864; DOI: 10.1371/journal.pone.0045474;.

Li L, Zhang F, Zaia J, Linhardt RJ. Top-down approach for the direct characterization of low molecular weight heparins using LC-FT-MS. Anal Chem. 2012 Oct 16; 84(20):8822-9. PMID: 22985071; PMCID: PMC3479637; DOI: 10.1021/ac302232c;.

Gill VL, Wang Q, Shi X, Zaia J. Mass spectrometric method for determining the uronic acid epimerization in heparan sulfate disaccharides generated using nitrous acid. Anal Chem. 2012 Sep 4; 84(17):7539-46.View Related Profiles.

Zaia, Joseph
Wang, Qi
Shi, Xiaofeng

PMID: 22873817; PMCID: PMC3437266; DOI: 10.1021/ac3016054;.

Tran TH, Shi X, Zaia J, Ai X. Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration. J Biol Chem. 2012 Sep 21; 287(39):32651-64.View Related Profiles.

Zaia, Joseph
Tran, Thanh
Shi, Xiaofeng
Ai, Xingbin

PMID: 22865881; PMCID: PMC3463311.

Shi X, Huang Y, Mao Y, Naimy H, Zaia J. Tandem mass spectrometry of heparan sulfate negative ions: sulfate loss patterns and chemical modification methods for improvement of product ion profiles. J Am Soc Mass Spectrom. 2012 Sep; 23(9):1498-511.View Related Profiles.

Zaia, Joseph
Shi, Xiaofeng
Mao, Yang
Huang, Yu

PMID: 22825743; DOI: 10.1007/s13361-012-0429-4;.

Lu Z, Madico G, Roche MI, Wang Q, Hui JH, Perkins HM, Zaia J, Costello CE, Sharon J. Protective B-cell epitopes of Francisella tularensis O-polysaccharide in a mouse model of respiratory tularaemia. Immunology. 2012 Jul; 136(3):352-60.View Related Profiles.

Costello, Catherine
Madico, Guillermo
Sharon, Jacqueline
Zaia, Joseph
Wang, Qi
Lu, Zhaohua

PMID: 22486311; PMCID: PMC3385035; DOI: 10.1111/j.1365-2567.2012.03589.x;.

Leymarie N, Zaia J. Effective use of mass spectrometry for glycan and glycopeptide structural analysis. Anal Chem. 2012 Apr 3; 84(7):3040-8.View Related Profiles.

Zaia, Joseph
Leymarie, Nancy

PMID: 22360375; PMCID: PMC3319649; DOI: 10.1021/ac3000573;.

Thelin MA, Svensson KJ, Shi X, Bagher M, Axelsson J, Isinger-Ekstrand A, van Kuppevelt TH, Johansson J, Nilbert M, Zaia J, Belting M, Maccarana M, Malmström A. Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma. Cancer Res. 2012 Apr 15; 72(8):1943-52. PMID: 22350411; PMCID: PMC3328612; DOI: 10.1158/0008-5472.CAN-11-1351;.

Rosas-Alquicira G, Acosta-Blano I, Ortega-Francisco S, Fuentes-Romero LL, Newburg DS, Ruiz-Palacios G, Mao Y, Zaia J, Viveros-Rogel M. Joint Meeting of the Society for Glycobiology and American Society for Matrix Biology. Human milk Glycosaminoglycans inhibit HIV-1 primary isolate in vitro infection. Glycobiology Journal. San Diego. 2012; 22(11):1632.

Mao Y, Huang Y, Wu L, Zaia J. Joint Meeting of the Society-for-Glycobiology. Characterization of the substratum specificity of mammalian heparanase using the aglycomic approach. Glycobiology. 2012; 22.

Jonscher K, Kolarich D, Zaia J, Leymarie N. (gPRG) 2012 Quantitative Glycoprotein Study. Journal of biomolecular techniques: JBT. 2012; 23(Suppl):S16-S17.

Staples GO, Zaia J. Analysis of Glycosaminoglycans Using Mass Spectrometry. Curr Proteomics. 2011; 8:325-336. View Publication

Wang Q, Shi X, Leymarie N, Madico G, Sharon J, Costello CE, Zaia J. A typical preparation of Francisella tularensis O-antigen yields a mixture of three types of saccharides. Biochemistry. 2011 Dec 20; 50(50):10941-50.View Related Profiles.

Costello, Catherine
Madico, Guillermo
Sharon, Jacqueline
Zaia, Joseph
Leymarie, Nancy
Wang, Qi
Shi, Xiaofeng

PMID: 22091710; PMCID: PMC3238095; DOI: 10.1021/bi201450v;.

Huang Y, Shi X, Yu X, Leymarie N, Staples GO, Yin H, Killeen K, Zaia J. Improved liquid chromatography-MS/MS of heparan sulfate oligosaccharides via chip-based pulsed makeup flow. Anal Chem. 2011 Nov 1; 83(21):8222-9.View Related Profiles.

Zaia, Joseph
Leymarie, Nancy
Shi, Xiaofeng
Huang, Yu

PMID: 21923145; PMCID: PMC3205275; DOI: 10.1021/ac201964n;.

Crouch E, Nikolaidis N, McCormack FX, McDonald B, Allen K, Rynkiewicz MJ, Cafarella TM, White M, Lewnard K, Leymarie N, Zaia J, Seaton BA, Hartshorn KL. Mutagenesis of surfactant protein D informed by evolution and x-ray crystallography enhances defenses against influenza A virus in vivo. J Biol Chem. 2011 Nov 25; 286(47):40681-92.View Related Profiles.

Seaton, Barbara
Zaia, Joseph
Hartshorn, Kevan
Rynkiewicz, Michael
Leymarie, Nancy

PMID: 21965658; PMCID: PMC3220461; DOI: 10.1074/jbc.M111.300673;.

Bielik AM, Zaia J. Multistage Tandem Mass Spectrometry of Chondroitin Sulfate and Dermatan Sulfate. Int J Mass Spectrom. 2011 Aug 15; 305(2-3):131-137. PMID: 21860601; DOI: 10.1016/j.ijms.2010.10.017;.

Leymarie N, McComb ME, Naimy H, Staples GO, Zaia J. Differential Characterization and Classification of Tissue Specific Glycosaminoglycans by Tandem Mass Spectrometry and Statistical Methods. Int J Mass Spectrom. 2012 Feb 15; 312:144-154.View Related Profiles.

Zaia, Joseph
McComb, Mark
Leymarie, Nancy

PMID: 22523474; DOI: 10.1016/j.ijms.2011.07.019;.

Schumacher VA, Schlötzer-Schrehardt U, Karumanchi SA, Shi X, Zaia J, Jeruschke S, Zhang D, Pavenstädt H, Pavenstaedt H, Drenckhan A, Amann K, Ng C, Hartwig S, Ng KH, Ho J, Kreidberg JA, Taglienti M, Royer-Pokora B, Ai X. WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J Am Soc Nephrol. 2011 Jul; 22(7):1286-96.View Related Profiles.

Zaia, Joseph
Ai, Xingbin

PMID: 21719793; PMCID: PMC3137576; DOI: 10.1681/ASN.2010080860;.

Naimy H, Buczek-Thomas JA, Nugent MA, Leymarie N, Zaia J. Highly sulfated nonreducing end-derived heparan sulfate domains bind fibroblast growth factor-2 with high affinity and are enriched in biologically active fractions. J Biol Chem. 2011 Jun 3; 286(22):19311-9.View Related Profiles.

Buczek-Thomas, JoAnn
Zaia, Joseph
Nugent, Matthew
Leymarie, Nancy

PMID: 21471211; PMCID: PMC3103309; DOI: 10.1074/jbc.M110.204693;.

Staples GO, Shi X, Zaia J. Glycomics analysis of mammalian heparan sulfates modified by the human extracellular sulfatase HSulf2. PLoS One. 2011; 6(2):e16689.View Related Profiles.

Zaia, Joseph
Shi, Xiaofeng

PMID: 21347431; PMCID: PMC3035651; DOI: 10.1371/journal.pone.0016689;.

Zaia J. At last, functional glycomics. Nat Methods. 2011 Jan; 8(1):55-7. PMID: 21191374; DOI: 10.1038/nmeth0111-55;.

Leymarie N, Hartshorn K, White MR, Cafarella T, Seaton B, Rynkiewicz MJ, Zaia J. Annual Conference of the Society-for-Glycobiology. Studies on Site-Specific N-Glycosylation of Hemagglutinin from Influenza AViruse Phil82 and Surfactant Protein D. Glycobiology. 2011.

Bielik A, Mcleod E, Landry D, Mendoza V, Zaia J, Guthrie EP. Annual Conference of the Society-for-Glycobiology. Characterization of Three Novel Heparinases Cloned from Bacteroides eggerthii. Glycobiology. 2011; 21.

Huang Yu Shi X, Zaia J. Annual Conference of the Society-for-Glycobiology. LC-MS and LC-MS/MS Study of Heparan Sulfate Oligosaccharides Processed by Human Sulf-2. Glycobiology. 2011; 21.

Mao Y, Newburg DS, Costello CE, Zaia J. Annual Conference of the Society-for-Glycobiology. Comparative Glycomics of Human and Bovine Milk Glycosaminoglycans. Gylcobiology. 2011; 21.

Kolarich D, Orlando R, Zaia J. gPRG: Toward Consensus on Glycan Analysis: Reliable Methods and Reproducibility. Journal of biomolecular techniques: JBT. 2011; 22(Suppl):S22.

Staples G, Zaia J. Carbohydrate Recognition: Biological Problems, Methods, and Applications. Mass Spectrometry in Carbohydrate Sequencing and Binding Analysis. 2011; 257-300. View Publication

Rynkiewicz MJ, Luo D, Leymarie N, Crouch EC, Hartshorn KL, Head JF, Mccormack FX, van Eijk M, Zaia J, Seaton BA. Mechanisms of Interaction Between Lung Collectins and Influenza a Virus Hemagglutinin. Biophysical Journal. 2011; 100(3). View Publication

Hollingsworth MT, Hart GW, Paulson JC, Lebrilla C, Zaia J et al. Glycobiology. Program and abstracts for the 2011 Meeting of the Society for Glycobiology. 2011; 21(11):1454-1531. View Publication

Naimy H, Leymarie N, Buczek-Thomas JA, Nugent MA, Zaia J. Annual Conference of the Society-for-Glycobiology. Characterization of Heparan Sulfate N-Sulfated Domains Binding Fibroblast Growth Factor-2. Glycobiology. 2011; 20.

Staples GO, Zaia J. Analysis of Glycosaminoglycans Using Mass Spectrometry. Curr Proteomics. 2011; 8(4):325-336. PMID: 25705143.

Staples GO, Zaia J. In Carbohydrate Recognition; Wang B, Boons GJ, Eds. John Wiley & Sons, Inc. Hoboken. 2011; 257-300.

Dreyfuss JM, Jacobs C, Gindin Y, Benson G, Staples GO, Zaia J. Targeted analysis of glycomics liquid chromatography/mass spectrometry data. Anal Bioanal Chem. 2011 Jan; 399(2):727-35. PMID: 20953780; PMCID: PMC3254673; DOI: 10.1007/s00216-010-4235-1;.

Langsdorf A, Schumacher V, Shi X, Tran T, Zaia J, Jain S, Taglienti M, Kreidberg JA, Fine A, Ai X. Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche. Glycobiology. 2011 Feb; 21(2):152-61.View Related Profiles.

Fine, Alan
Zaia, Joseph
Tran, Thanh
Shi, Xiaofeng
Ai, Xingbin

PMID: 20855470; PMCID: PMC3031337; DOI: 10.1093/glycob/cwq133;.

Zaia J. Mass spectrometry and glycomics. OMICS. 2010 Aug; 14(4):401-18. PMID: 20443730; PMCID: PMC3133787; DOI: 10.1089/omi.2009.0146;.

Naimy H, Leymarie N, Zaia J. Screening for anticoagulant heparan sulfate octasaccharides and fine structure characterization using tandem mass spectrometry. Biochemistry. 2010 May 4; 49(17):3743-52.View Related Profiles.

Zaia, Joseph
Leymarie, Nancy

PMID: 20345121; PMCID: PMC3251171; DOI: 10.1021/bi100135d;.

Staples GO, Shi X, Zaia J. Extended N-sulfated domains reside at the nonreducing end of heparan sulfate chains. J Biol Chem. 2010 Jun 11; 285(24):18336-43.View Related Profiles.

Zaia, Joseph
Shi, Xiaofeng

PMID: 20363743; PMCID: PMC2881759; DOI: 10.1074/jbc.M110.101592;.

Bowman MJ, Zaia J. Comparative glycomics using a tetraplex stable-isotope coded tag. Anal Chem. 2010 Apr 1; 82(7):3023-31. PMID: 20230064; PMCID: PMC2854645; DOI: 10.1021/ac100108w;.

Staples GO, Naimy H, Yin H, Kileen K, Kraiczek K, Costello CE, Zaia J. Improved hydrophilic interaction chromatography LC/MS of heparinoids using a chip with postcolumn makeup flow. Anal Chem. 2010 Jan 15; 82(2):516-22.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 20000724; PMCID: PMC3247906; DOI: 10.1021/ac901706f;.

Bielik AM, Zaia J. Historical overview of glycoanalysis. Methods Mol Biol. 2010; 600:9-30. PMID: 19882118; DOI: 10.1007/978-1-60761-454-8_2;.

Bielik AM, Zaia J. Extraction of chondroitin/dermatan sulfate glycosaminoglycans from connective tissue for mass spectrometric analysis. Methods Mol Biol. 2010; 600:215-25. PMID: 19882131; DOI: 10.1007/978-1-60761-454-8_15;.

Naimy H, Staples G, Mccomb ME, Costello CE, Zaia J, Leymarie N. Patterns of Tissue-Specific Glycosaminoglycan Expression Revealed by Tandem Mass Spectrometry and Statistical Methods. Journal of biomolecular techniques: JBT. 2010; 21(3 Suppl).

Huang Y, Shi X, Yin H, Staples G, Killeen K, Zaia J. Annual Conference of the Society-for-Glycobiology. Improved Heparan Sulfate Oligosaccharide Structural Analysis using LC-Tandem Mass Spectrometry with Post-Column Charge State Manipulation. Glycobiology. 2010; 20.

Zaia J. On-line separations combined with MS for analysis of glycosaminoglycans. Mass Spectrom Rev. 2009 Mar-Apr; 28(2):254-72. PMID: 18956477; DOI: 10.1002/mas.20200;.

Shi X, Zaia J. Organ-specific heparan sulfate structural phenotypes. J Biol Chem. 2009 May 1; 284(18):11806-14.View Related Profiles.

Zaia, Joseph
Shi, Xiaofeng

PMID: 19244235; PMCID: PMC2673249; DOI: 10.1074/jbc.M809637200;.

Staples GO, Bowman MJ, Costello CE, Hitchcock AM, Lau JM, Leymarie N, Miller C, Naimy H, Shi X, Zaia J. A chip-based amide-HILIC LC/MS platform for glycosaminoglycan glycomics profiling. Proteomics. 2009 Feb; 9(3):686-95.View Related Profiles.

Costello, Catherine
Zaia, Joseph
Leymarie, Nancy
Shi, Xiaofeng

PMID: 19137549; PMCID: PMC2771417; DOI: 10.1002/pmic.200701008;.

Zaia J, Shi X. Reply to Savolainen: Organ- and Cell-specific GAG Chains. Journal of Biological Chemistry. 2009; 284(18):le2. View Publication

Shi S, Staples G, Leymarie N, Naimy H, Zaia J. 36th American Chemical Society Northeast Regional Meeting. Glycomics of Heparan Sulfate. 2009.

Naimy H, Leymarie N, Zaia J. Annual Meeting of the Society-for-Glycobiology. Diagnostic Ions for Anticoagulant Heparan Sulfate Octasaccharides by Low Energy CID Tandem Mass Spectrometry. Glycobiology. 2009; 19.

Staples G, Zaia J. Annual Meeting of the Society-for-Glycobiology. Domain Structure Analysis of Heparan Sulfates by Mass Spectrometry. Glycobiology. 2009; 19.

Leymarie N, Staples G, Naimy H, Mccomb ME, Zaia J. Annual Meeting of the Society-for-Glycobiology. Tandem Mass Spectrometry and Statistical Methods: Tools Used to Differentiate, Characterize and Classify Tissues Specific Glycosaminoglycans. Glycobiology. 2009; 19.

Hitchcock AM, Bowman MJ, Staples GO, Zaia J. Improved workup for glycosaminoglycan disaccharide analysis using CE with LIF detection. Electrophoresis. 2008 Nov; 29(22):4538-48. PMID: 19035406; PMCID: PMC2810710; DOI: 10.1002/elps.200800335;.

Zaia J. Mass spectrometry and the emerging field of glycomics. Chem Biol. 2008 Sep 22; 15(9):881-92. PMID: 18804025; PMCID: PMC2570164; DOI: 10.1016/j.chembiol.2008.07.016;.

Hitchcock AM, Yates KE, Costello CE, Zaia J. Comparative glycomics of connective tissue glycosaminoglycans. Proteomics. 2008 Apr; 8(7):1384-97.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 18318007; PMCID: PMC2577024; DOI: 10.1002/pmic.200700787;.

Naimy H, Leymarie N, Bowman MJ, Zaia J. Characterization of heparin oligosaccharides binding specifically to antithrombin III using mass spectrometry. Biochemistry. 2008 Mar 11; 47(10):3155-61.View Related Profiles.

Zaia, Joseph
Leymarie, Nancy

PMID: 18260648; PMCID: PMC2716047; DOI: 10.1021/bi702043e;.

Staples G, Leymarie N, Naimy H, Zaia J. Annual Meeting of the Society-for-Glycobiology. Informatics for Complex Glycan Mass Spectral Datasets. Glycobiology. 2008; 18.

Naimy H, Leymarie N, Zaia J. Annual Meeting of the Society-for-Glycobiology. Functional Characterization of Heparinoid Octasaccharide Libraries Using LC/MS. Glycobiology. 2008; 18.

Staples G, Costello CE, Zaia J. Annual Meeting of the Society-for-Glycobiology. Structural Analysis of Sulf2 Activity on Heparan Sulfate Domains. Glycobiology. 2008; 18.

Bowman MJ, Zaia J. Tags for the stable isotopic labeling of carbohydrates and quantitative analysis by mass spectrometry. Anal Chem. 2007 Aug 1; 79(15):5777-84. PMID: 17605469; PMCID: PMC2532755.

Zaia J, Miller MJ, Seymour JL, Costello CE. The role of mobile protons in negative ion CID of oligosaccharides. J Am Soc Mass Spectrom. 2007 May; 18(5):952-60.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 17383193; PMCID: PMC1964798.

Hitchcock AM, Yates KE, Shortkroff S, Costello CE, Zaia J. Optimized extraction of glycosaminoglycans from normal and osteoarthritic cartilage for glycomics profiling. Glycobiology. 2007 Jan; 17(1):25-35.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 16980326; PMCID: PMC2630472.

Ziegler A, Zaia J. Size-exclusion chromatography of heparin oligosaccharides at high and low pressure. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6; 837(1-2):76-86. PMID: 16704936.

Seymour JL, Costello CE, Zaia J. The influence of sialylation on glycan negative ion dissociation and energetics. J Am Soc Mass Spectrom. 2006 Jun; 17(6):844-54.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 16603372; PMCID: PMC2586975.

Hitchcock AM, Costello CE, Zaia J. Glycoform quantification of chondroitin/dermatan sulfate using a liquid chromatography-tandem mass spectrometry platform. Biochemistry. 2006 Feb 21; 45(7):2350-61.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 16475824; PMCID: PMC2597419.

Miller MJ, Costello CE, Malmström A, Zaia J. A tandem mass spectrometric approach to determination of chondroitin/dermatan sulfate oligosaccharide glycoforms. Glycobiology. 2006 Jun; 16(6):502-13.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 16489125; PMCID: PMC2577607.

Zaia J, Campuzano I, Giles K, Bateman R, Keith C, Costello CE. Meeting of the Society-for-Gylcobiology. Electrospray ion mobility spectrometry of isomeric carbohydrates. Glycobiology. 2006; 16.

Hitchcock AM, Costello CE, Zaia J. Meeting of the Society-for-Gylcobiology. Comparative glycomics of connective tissue glycosaminoglycans using mass spectrometry. Glycobiology. 2006; 16.

Zaia J. In Ionization Methods; Gross ML, Caprioli RM, Eds. Elsevier. Amsterdam. 2006; 6:889-903.

Zaia J. Principles of Mass Spectrometry of Glycosaminoglycans. Journal of Biomacromolecular Mass Spectrometry. 2005; 1:3-36.

Zaia J, Seymour JL, Costello CE. Meeting of the Society-for-Glycobiology. Glycomics using negative ion tandem mass spectrometry of native glycans. Glycobiology. 2005; 15.

Hitchcock AM, Costello CE, Zaia J. Meeting of the Society-for-Glycobiology. An LC/MS/MS platform for glycoform quantification of chondroitin sulfate. Glycobiology. 2005; 15.

Naggar EF, Costello CE, Zaia J. Competing fragmentation processes in tandem mass spectra of heparin-like glycosaminoglycans. J Am Soc Mass Spectrom. 2004 Nov; 15(11):1534-44.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 15519220.

Zaia J. Mass spectrometry of oligosaccharides. Mass Spectrom Rev. 2004 May-Jun; 23(3):161-227. PMID: 14966796.

Costello CE, Blackmun-Ross KE, Budnik BA, Elkin Y, Ivleva VB, Steen JA, Pittman JL, Xie B, Mccomb ME, O'Connor PB, Zaia J. Glycobiology. Sample preparation and mass spectral fragmentation methods for use in glycobiology. 2004.

Zaia J, Li XQ, Chan SY, Costello CE. Tandem mass spectrometric strategies for determination of sulfation positions and uronic acid epimerization in chondroitin sulfate oligosaccharides. J Am Soc Mass Spectrom. 2003 Nov; 14(11):1270-81.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 14597117.

Zaia J, Costello CE. Tandem mass spectrometry of sulfated heparin-like glycosaminoglycan oligosaccharides. Anal Chem. 2003 May 15; 75(10):2445-55.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 12918989.

Naggar EF, Costello CE, Zaia J. 8th Annual Conference of the Society-for-Glycobiology. Identification and sequencing of protein binding heparin-like glycosaminoglycan oligosaccharides. Glycobiology. 2003; 13.

Costello CE, Mccomb ME, O'Connor PB, Zaia J. 8th Annual Conference of the Society-for-Glycobiology. Mass spectrometry-based methods for revealing the Glyeans' family secrets. Gylcobiology. 2003; 13.

McClellan JE, Costello CE, O'Connor PB, Zaia J. Influence of charge state on product ion mass spectra and the determination of 4S/6S sulfation sequence of chondroitin sulfate oligosaccharides. Anal Chem. 2002 Aug 1; 74(15):3760-71.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 12175164.

Zaia J, Costello CE. 7th Annual Conference of the Society-for-Glycobiology. A new approach for sequencing heparins. Glycobiology. 2002; 12.

Zaia J, McClellan JE, Costello CE. Tandem mass spectrometric determination of the 4S/6S sulfation sequence in chondroitin sulfate oligosaccharides. Anal Chem. 2001 Dec 15; 73(24):6030-9.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 11791576.

Barry F, Boynton R, Murphy M, Haynesworth S, Zaia J. The SH-3 and SH-4 antibodies recognize distinct epitopes on CD73 from human mesenchymal stem cells. Biochem Biophys Res Commun. 2001 Nov 30; 289(2):519-24. PMID: 11716504.

Zaia J, Boynton R, Heinegård D, Barry F. Posttranslational modifications to human bone sialoprotein determined by mass spectrometry. Biochemistry. 2001 Oct 30; 40(43):12983-91. PMID: 11669636.

Zaia J, Costello CE. Compositional analysis of glycosaminoglycans by electrospray mass spectrometry. Anal Chem. 2001 Jan 15; 73(2):233-9.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 11199971.

Cheng X, Cole RN, Zaia J, Hart GW. Alternative O-glycosylation/O-phosphorylation of the murine estrogen receptor beta. Biochemistry. 2000 Sep 26; 39(38):11609-20. PMID: 10995228.

Zaia J, Liu B, Boynton R, Barry F. Structural analysis of cartilage proteoglycans and glycoproteins using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem. 2000 Jan 1; 277(1):94-103. PMID: 10610693.

Zaia J, Costello CE. Characterization of glycosaminoglycan structure using mass spectrometry. Glycobiology. 2000; 10(10):1093.

Barry FP, Boynton RE, Haynesworth S, Murphy JM, Zaia J. The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105). Biochem Biophys Res Commun. 1999 Nov; 265(1):134-9. PMID: 10548503.

Fenselau C, Antoine MD, Fabris D, Hathout Y, He T, Zaia J. Metallothionein IV. A chemical mechanism for inactivation of anticancer drugs by metallothionein. 1999; 577-580. View Publication

Fenselau C, Antoine MD, Fabris D, Hathout Y, He T, Zaia J. In Metallothionein IV; Klaasen C, Ed. Birkhauser. Basel. 1999; 577-580.

Zaia J, Fabris D, Wei D, Karpel RL, Fenselau C. Monitoring metal ion flux in reactions of metallothionein and drug-modified metallothionein by electrospray mass spectrometry. Protein Sci. 1998 Nov; 7(11):2398-404. PMID: 9828006; PMCID: PMC2143854.

van den Bos C, Rammes A, Vogl T, Boynton R, Zaia J, Sorg C, Roth J. Copurification of P6, MRP8, and MRP14 from human granulocytes and separation of individual proteins. Protein Expr Purif. 1998 Aug; 13(3):313-8. PMID: 9693055.

Bruder SP, Ricalton NS, Boynton RE, Connolly TJ, Jaiswal N, Zaia J, Barry FP. Mesenchymal stem cell surface antigen SB-10 corresponds to activated leukocyte cell adhesion molecule and is involved in osteogenic differentiation. J Bone Miner Res. 1998 Apr; 13(4):655-63. PMID: 9556065.

Zaia J, Boynton RE, McIntosh A, Marshak DR, Olsson H, Heinegârd D, Barry FP. Post-translational modifications in cartilage oligomeric matrix protein. Characterization of the N-linked oligosaccharides by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. J Biol Chem. 1997 May 30; 272(22):14120-6. PMID: 9162039.

Zaia J, Jiang L, Han MS, Tabb JR, Wu Z, Fabris D, Fenselau C. A binding site for chlorambucil on metallothionein. Biochemistry. 1996 Mar 5; 35(9):2830-5. PMID: 8608118.

Zaia J, Boynton R, Heinegard D, Barry F. Patterns of glycosylation in cartilage oligomeric matrix protein measured by monosaccharide composition analysis, MALDI/TOF and electrospray mass spectrometry. Glycobiology. 1996; 6(7):115.

Zaia J. Charged derivatives for peptide sequencing using a magnetic sector instrument. Methods Mol Biol. 1996; 61:29-41. PMID: 8930863.

Fabris D, Zaia J, Hathout Y, Fenselau C. Retention of thiol protons in two classes of protein zinc ion coordination centers. J Am Chem Soc. 1996; 118:12242-12243. View Publication

Zaia J, Biemann K. Comparison of charged derivatives for high energy collision-induced dissociation tandem mass spectrometry. J Am Soc Mass Spectrom. 1995; 6(5):428-436. View Publication

Day BW, Skipper PL, Zaia J, Singh K, Tannenbaum SR. Enantiospecificity of covalent adduct formation by benzo[a]pyrene anti-diol epoxide with human serum albumin. Chem Res Toxicol. 1994 Nov-Dec; 7(6):829-35. PMID: 7696539.

Zaia J, Biemann K. Characteristics of high energy collision-induced dissociation tandem mass spectra of polycyclic aromatic hydrocarbon diolepoxide adducted peptides. J Am Soc Mass Spectrom. 1994; 5(7):649-654. View Publication

Zaia J, Biemann K. Proteinase K activity inhibited near amino acids carrying large substituents: three PAH diolepoxides covalently modify His-146 human serum albumin residues. J Am Chem Soc. 1994; 116:7407-7408. View Publication

Zaia J, Annan RS, Biemann K. The correct molecular weight of myoglobin, a common calibrant for mass spectrometry. Rapid Commun Mass Spectrom. 1992 Jan; 6(1):32-6. PMID: 1591398.

Day BW, Skipper PL, Zaia J, Tannenbaum SR. Benzo[a]pyrene anti-diol epoxide covalently modifies human serum albumin carboxylate side chains and imidazole side chains of histidine(146). J Am Chem Soc. 1991; 113:8505-8509. View Publication

Nicholson-Weller A, Zaia J, Raum MG, Coligan JE. Decay accelerating factor (DAF) peptide sequences share homology with a consensus sequence found in the superfamily of structurally related complement proteins and other proteins including haptoglobin, factor XIII, beta 2-glycoprotein I, and the IL-2 receptor. Immunol Lett. 1987 Apr; 14(4):307-11. PMID: 2438213.

Wenzel TJ, Zaia J. Organic-Soluble Lanthanide Nuclear-Magnetic-Resonance Shift-Reagents for Sulfonium and Isothiouronium Salts. Anal Chem. 1987; 59:562-567. View Publication

Wenzel TJ, Zaia J. Lanthanide Tetrakis (Beta-Diketonates) as Effective NMR Shift-Reagents for Organic Salts. J Org Chem. 1985; 50:1322-1324. View Publication

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 167 publications over 29 distinct years, with a maximum of 22 publications in 2011

Bar chart showing 167 publications over 29 distinct years, with a maximum of 22 publications in 2011

Year	Publications
1985	1
1987	2
1991	1
1992	1
1994	3
1995	1
1996	4
1997	1
1998	3
1999	3
2000	3
2001	4
2002	2
2003	4
2004	3
2005	3
2006	8
2007	2
2008	7
2009	8
2010	11
2011	22
2012	11
2013	16
2014	10
2015	8
2016	10
2017	5
2018	10

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

glycomics
glycosaminoglycan
heparan sulfate
heparin
mass spectrometry
proteoglycan

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