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MD, Semmelweis University
PhD, Semmelweis University

Websites

	ResearchGate
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ORCID : 0000-0003-4513-9922

Research
Publications

BU Research
NIH RePORTER Research

Molecular Pathomechanism of Hereditary Pancreatitis
09/30/2015 - 03/31/2019 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK058088-17

Chymotrypsin C in Pancreatitis
04/01/2014 - 03/31/2019 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK082412-09

Trypsin-dependent mechanisms in pancreatitis
07/01/2018 - 02/28/2019 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
1R01DK117809-01

Digestive enzyme misfolding promotes alcoholic pancreatitis
02/15/2018 - 02/28/2019 (PI)
NIH/National Institute on Alcohol Abuse and Alcoholism
5R21AA026456-02

study of one of the human digestive enzynes named elastase (Rosztoczy Foundation Schloarship Award)
01/01/2018 - 12/31/2018 (PI)
Rosztoczy Foundation

Pancreatice elastases
01/01/2016 - 12/31/2017 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
4R01DK095753-04

Mouse Model of Human Hereditary Pancreatitis
09/01/2014 - 08/31/2017 (PI)
Department of Defense/Army Medical Research Acquisition Activity

Genomic structural variants at the CTRB1/CTRB2 locus in chronic pancreatitis
06/01/2016 - 05/31/2017 (Key Person / Mentor)
The National Pancreas Foundation

Pancreatic Elastases
01/01/2013 - 12/31/2015 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK095753-03

Molecular Pathomechanism of Hereditary Pancreatitis
07/01/2010 - 09/29/2015 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK058088-13

Showing 10 of 22 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Chymotrypsin in pancreatitis	5R01DK082412-13
2023	Chymotrypsin in pancreatitis	5R01DK082412-12
2022	Trypsin-dependent mechanisms in pancreatitis	5R01DK117809-05
2022	Chymotrypsin in pancreatitis	5R01DK082412-11
2021	Trypsin-dependent mechanisms in pancreatitis	5R01DK117809-04	2
2021	Chymotrypsin in pancreatitis	2R01DK082412-10A1	35
2020	Trypsin-dependent mechanisms in pancreatitis	5R01DK117809-03	2
2019	Trypsin-dependent mechanisms in pancreatitis	7R01DK117809-02	2
2019	Digestive enzyme misfolding promotes alcoholic pancreatitis	5R21AA026456-02
2019	Digestive enzyme misfolding promotes alcoholic pancreatitis	7R21AA026456-03

Showing 10 of 49 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Jancsó Z, Hegyi E, Sahin-Tóth M. Chymotrypsin Reduces the Severity of Secretagogue-Induced Pancreatitis in Mice. Gastroenterology. 2018 10; 155(4):1017-1021. PMID: 30076839; PMCID: PMC6200337; DOI: 10.1053/j.gastro.2018.06.041;

Hegyi E, Sahin-Tóth M. Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice. Gut. 2019 02; 68(2):301-312. PMID: 30045879; PMCID: PMC6326849; DOI: 10.1136/gutjnl-2018-315994;

Párniczky A, Abu-El-Haija M, Husain S, Lowe M, Oracz G, Sahin-Tóth M, Szabó FK, Uc A, Wilschanski M, Witt H, Czakó L, Grammatikopoulos T, Rasmussen IC, Sutton R, Hegyi P. EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis. Pancreatology. 2018 Mar; 18(2):146-160. PMID: 29398347

Sahin-Tóth M. Partial and complete SPINK1 deficiency cause distinct pancreatic phenotypes. Hum Mutat. 2017 12; 38(12):1619. PMID: 29091332

Németh BC, Szücs Á, Hegyi P, Sahin-Tóth M. Novel PRSS1 Mutation p.P17T Validates Pathogenic Relevance of CTRC-Mediated Processing of the Trypsinogen Activation Peptide in Chronic Pancreatitis. Am J Gastroenterol. 2017 12; 112(12):1896-1898. PMID: 29215622; PMCID: PMC5933932; DOI: 10.1038/ajg.2017.393;

Sahin-Tóth M, Hegyi P. Smoking and Drinking Synergize in Pancreatitis: Multiple Hits on Multiple Targets. Gastroenterology. 2017 12; 153(6):1479-1481. PMID: 29100845

Márta K, Szabó AN, Pécsi D, Varjú P, Bajor J, Gódi S, Sarlós P, Mikó A, Szemes K, Papp M, Tornai T, Vincze Á, Márton Z, Vincze PA, Lankó E, Szentesi A, Molnár T, Hágendorn R, Faluhelyi N, Battyáni I, Kelemen D, Papp R, Miseta A, Verzár Z, Lerch MM, Neoptolemos JP, Sahin-Tóth M, Petersen OH, Hegyi P. High versus low energy administration in the early phase of acute pancreatitis (GOULASH trial): protocol of a multicentre randomised double-blind clinical trial. BMJ Open. 2017 Sep 14; 7(9):e015874. PMID: 28912191; PMCID: PMC5722094; DOI: 10.1136/bmjopen-2017-015874;

Sahin-Tóth M. Genetic risk in chronic pancreatitis: the misfolding-dependent pathway. Curr Opin Gastroenterol. 2017 Sep; 33(5):390-395. PMID: 28650851; PMCID: PMC5549634; DOI: 10.1097/MOG.0000000000000380;

Rosendahl J, Kirsten H, Hegyi E, Kovacs P, Weiss FU, Laumen H, Lichtner P, Ruffert C, Chen JM, Masson E, Beer S, Zimmer C, Seltsam K, Algül H, Bühler F, Bruno MJ, Bugert P, Burkhardt R, Cavestro GM, Cichoz-Lach H, Farré A, Frank J, Gambaro G, Gimpfl S, Grallert H, Griesmann H, Grützmann R, Hellerbrand C, Hegyi P, Hollenbach M, Iordache S, Jurkowska G, Keim V, Kiefer F, Krug S, Landt O, Leo MD, Lerch MM, Lévy P, Löffler M, Löhr M, Ludwig M, Macek M, Malats N, Malecka-Panas E, Malerba G, Mann K, Mayerle J, Mohr S, Te Morsche RHM, Motyka M, Mueller S, Müller T, Nöthen MM, Pedrazzoli S, Pereira SP, Peters A, Pfützer R, Real FX, Rebours V, Ridinger M, Rietschel M, Rösmann E, Saftoiu A, Schneider A, Schulz HU, Soranzo N, Soyka M, Simon P, Skipworth J, Stickel F, Strauch K, Stumvoll M, Testoni PA, Tönjes A, Werner L, Werner J, Wodarz N, Ziegler M, Masamune A, Mössner J, Férec C, Michl P, P H Drenth J, Witt H, Scholz M, Sahin-Tóth M. Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis. Gut. 2018 10; 67(10):1855-1863.View Related Profiles.

Sahin-Toth, Miklos
Beer, Sebastian

PMID: 28754779; PMCID: PMC6145291; DOI: 10.1136/gutjnl-2017-314454;

Kereszturi É, Sahin-Tóth M. Pancreatic Cancer Cell Lines Heterozygous for the SPINK1 p.N34S Haplotype Exhibit Diminished Expression of the Variant Allele. Pancreas. 2017 07; 46(6):e54-e55. PMID: 28609377; PMCID: PMC5470582; DOI: 10.1097/MPA.0000000000000817;

Showing 10 of 103 results. Show More

Wu H, Zhou DZ, Berki D, Geisz A, Zou WB, Sun XT, Hu LH, Zhao ZH, Zhao AJ, He L, Cooper DN, Férec C, Chen JM, Li ZS, Sahin-Tóth M, Liao Z. No significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort. Hum Mutat. 2017 Aug; 38(8):959-963.View Related Profiles.

Geisz, Andrea
Sahin-Toth, Miklos

PMID: 28497564; PMCID: PMC5542845; DOI: 10.1002/humu.23254;

Hegyi E, Sahin-Tóth M. Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway. Dig Dis Sci. 2017 07; 62(7):1692-1701. PMID: 28536777; PMCID: PMC5487703; DOI: 10.1007/s10620-017-4601-3;

Tóth AZ, Szabó A, Hegyi E, Hegyi P, Sahin-Tóth M. Detection of human elastase isoforms by the ScheBo Pancreatic Elastase 1 Test. Am J Physiol Gastrointest Liver Physiol. 2017 Jun 01; 312(6):G606-G614. PMID: 28360028; PMCID: PMC5495912; DOI: 10.1152/ajpgi.00060.2017;

Kujko AA, Berki DM, Oracz G, Wejnarska K, Antoniuk J, Wertheim-Tysarowska K, Kolodziejczyk E, Bal J, Sahin-Tóth M, Rygiel AM. A novel p.Ser282Pro CPA1 variant is associated with autosomal dominant hereditary pancreatitis. Gut. 2017 09; 66(9):1728-1730. PMID: 28258133; PMCID: PMC5933945; DOI: 10.1136/gutjnl-2017-313816;

Szücs Á, Marjai T, Szentesi A, Farkas N, Párniczky A, Nagy G, Kui B, Takács T, Czakó L, Szepes Z, Németh BC, Vincze Á, Pár G, Szabó I, Sarlós P, Illés A, Gódi S, Izbéki F, Gervain J, Halász A, Farkas G, Leindler L, Kelemen D, Papp R, Szmola R, Varga M, Hamvas J, Novák J, Bod B, Sahin-Tóth M, Hegyi P. Chronic pancreatitis: Multicentre prospective data collection and analysis by the Hungarian Pancreatic Study Group. PLoS One. 2017; 12(2):e0171420. PMID: 28207747; PMCID: PMC5313152; DOI: 10.1371/journal.pone.0171420;

Boros E, Szabó A, Zboray K, Héja D, Pál G, Sahin-Tóth M. Overlapping Specificity of Duplicated Human Pancreatic Elastase 3 Isoforms and Archetypal Porcine Elastase 1 Provides Clues to Evolution of Digestive Enzymes. J Biol Chem. 2017 02 17; 292(7):2690-2702. PMID: 28062577; PMCID: PMC5314167; DOI: 10.1074/jbc.M116.770560;

Németh BC, Patai ÁV, Sahin-Tóth M, Hegyi P. Misfolding cationic trypsinogen variant p.L104P causes hereditary pancreatitis. Gut. 2017 09; 66(9):1727-1728. PMID: 28011893; PMCID: PMC5481506; DOI: 10.1136/gutjnl-2016-313451;

Párniczky A, Hegyi E, Tóth AZ, Szücs Á, Szentesi A, Vincze Á, Izbéki F, Németh BC, Hegyi P, Sahin-Tóth M. Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis. Int J Mol Sci. 2016 12 20; 17(12):2148. PMID: 27999401; PMCID: PMC5187948; DOI: 10.3390/ijms17122148;

Párniczky A, Kui B, Szentesi A, Balázs A, Szucs Á, Mosztbacher D, Czimmer J, Sarlós P, Bajor J, Gódi S, Vincze Á, Illés A, Szabó I, Pár G, Takács T, Czakó L, Szepes Z, Rakonczay Z, Izbéki F, Gervain J, Halász A, Novák J, Crai S, Hritz I, Góg C, Sümegi J, Golovics P, Varga M, Bod B, Hamvas J, Varga-Müller M, Papp Z, Sahin-Tóth M, Hegyi P. Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis. PLoS One. 2016; 11(10):e0165309. PMID: 27798670; PMCID: PMC5087847; DOI: 10.1371/journal.pone.0165309;

Szabó A, Pilsak C, Bence M, Witt H, Sahin-Tóth M. Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. J Biol Chem. 2016 08 19; 291(34):17706-16. PMID: 27358403; PMCID: PMC5016165; DOI: 10.1074/jbc.M116.743237;

Jancsó Z, Sahin-Tóth M. Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis. J Biol Chem. 2016 Jun 17; 291(25):12897-905. PMID: 27129265; PMCID: PMC4933207; DOI: 10.1074/jbc.M116.725374;

Balázs A, Németh BC, Ördög B, Hegyi E, Hritz I, Czakó L, Czimmer J, Gódi S, Csiszkó A, Rakonczay Z, Párniczky A, Izbéki F, Halász A, Kahán Z, Hegyi P, Sahin-Tóth M. A Common CCK-B Receptor Intronic Variant in Pancreatic Adenocarcinoma in a Hungarian Cohort. Pancreas. 2016 Apr; 45(4):541-5. PMID: 26646278; PMCID: PMC4783207; DOI: 10.1097/MPA.0000000000000539;

Balázs A, Hegyi P, Sahin-Tóth M. Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2016 04 01; 310(7):G477-86. PMID: 26822915; PMCID: PMC4824176; DOI: 10.1152/ajpgi.00444.2015;

Hegyi E, Geisz A, Sahin-Tóth M, Derikx MH, Németh BC, Balázs A, Hritz I, Izbéki F, Halász A, Párniczky A, Takács T, Kelemen D, Sarlós P, Hegyi P, Czakó L. SPINK1 Promoter Variants in Chronic Pancreatitis. Pancreas. 2016 Jan; 45(1):148-53.View Related Profiles.

Geisz, Andrea
Sahin-Toth, Miklos

PMID: 26348468; DOI: 10.1097/MPA.0000000000000412;

Hegyi P, Wilschanski M, Muallem S, Lukacs GL, Sahin-Tóth M, Uc A, Gray MA, Rakonczay Z, Maléth J. CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis. Rev Physiol Biochem Pharmacol. 2016; 170:37-66. PMID: 26856995; PMCID: PMC5232416; DOI: 10.1007/112_2015_5002;

Mehner C, Oberg AL, Kalli KR, Nassar A, Hockla A, Pendlebury D, Cichon MA, Goergen KM, Maurer MJ, Goode EL, Keeney GL, Jatoi A, Sahin-Tóth M, Copland JA, Radisky DC, Radisky ES. Serine protease inhibitor Kazal type 1 (SPINK1) drives proliferation and anoikis resistance in a subset of ovarian cancers. Oncotarget. 2015 Nov 03; 6(34):35737-54. PMID: 26437224; PMCID: PMC4742138; DOI: 10.18632/oncotarget.5927;

Balázs A, Ruffert C, Hegyi E, Hritz I, Czakó L, Takács T, Szepes Z, Németh BC, Gervain J, Izbéki F, Halász A, Kelemen D, Szmola R, Novák J, Crai S, Illés A, Vincze Á, Molnár Z, Varga M, Bod B, Farkas G, Sümegi J, Szepes A, Dubravcsik Z, Lásztity N, Párniczky A, Hamvas J, Andorka C, Veres G, Szentkereszty Z, Rakonczay Z, Maléth J, Sahin-Tóth M, Rosendahl J, Hegyi P. Genetic analysis of the bicarbonate secreting anion exchanger SLC26A6 in chronic pancreatitis. Pancreatology. 2015 Sep-Oct; 15(5):508-513. PMID: 26372434; DOI: 10.1016/j.pan.2015.08.008;

Nakano E, Geisz A, Masamune A, Niihori T, Hamada S, Kume K, Kakuta Y, Aoki Y, Matsubara Y, Ebert K, Ludwig M, Braun M, Groneberg DA, Shimosegawa T, Sahin-Tóth M, Witt H. Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2015 Oct 15; 309(8):G688-94.View Related Profiles.

Geisz, Andrea
Sahin-Toth, Miklos

PMID: 26316592; PMCID: PMC4609930; DOI: 10.1152/ajpgi.00241.2015;

Szabó A, Ludwig M, Hegyi E, Szépeová R, Witt H, Sahin-Tóth M. Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis. J Biol Chem. 2015 Jul 10; 290(28):17282-92. PMID: 26013824; PMCID: PMC4498067; DOI: 10.1074/jbc.M114.618439;

Szabó A, Xiao X, Haughney M, Spector A, Sahin-Tóth M, Lowe ME. A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding. Biochim Biophys Acta. 2015 Jul; 1852(7):1372-9. PMID: 25862608; PMCID: PMC4645278; DOI: 10.1016/j.bbadis.2015.04.002;

Derikx MH, Geisz A, Kereszturi É, Sahin-Tóth M. Functional significance of SPINK1 promoter variants in chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2015 May 01; 308(9):G779-84.View Related Profiles.

Geisz, Andrea
Sahin-Toth, Miklos

PMID: 25792561; PMCID: PMC4421017; DOI: 10.1152/ajpgi.00022.2015;

Rygiel AM, Beer S, Simon P, Wertheim-Tysarowska K, Oracz G, Kucharzik T, Tysarowski A, Niepokój K, Kierkus J, Jurek M, Gawlinski P, Poznanski J, Bal J, Lerch MM, Sahin-Tóth M, Weiss FU. Gene conversion between cationic trypsinogen (PRSS1) and the pseudogene trypsinogen 6 (PRSS3P2) in patients with chronic pancreatitis. Hum Mutat. 2015 Mar; 36(3):350-6.View Related Profiles.

Sahin-Toth, Miklos
Beer, Sebastian

PMID: 25546417; PMCID: PMC4361298; DOI: 10.1002/humu.22747;

Dubravcsik Z, Farkas G, Hegyi P, Hritz I, Kelemen D, Lásztity N, Morvay Z, Oláh A, Pap Á, Párniczky A, Sahin-Tóth M, Szentkereszti Z, Szmola R, Takács T, Tiszlavicz L, Szücs Á, Czakó L. [Autoimmune pancreatitis. Evidence based management guidelines of the Hungarian Pancreatic Study Group]. Orv Hetil. 2015 Feb 22; 156(8):292-307. PMID: 25662147; DOI: 10.1556/OH.2015.30061;

Párniczky A, Czakó L, Dubravcsik Z, Farkas G, Hegyi P, Hritz I, Kelemen D, Morvay Z, Oláh A, Pap Á, Sahin-Tóth M, Szabó F, Szentkereszti Z, Szmola R, Takács T, Tiszlavicz L, Veres G, Szücs Á, Lásztity N. [Pediatric pancreatitis. Evidence based management guidelines of the Hungarian Pancreatic Study Group]. Orv Hetil. 2015 Feb 22; 156(8):308-25. PMID: 25662148; DOI: 10.1556/OH.2015.30062;

Szmola R, Farkas G, Hegyi P, Czakó L, Dubravcsik Z, Hritz I, Kelemen D, Lásztity N, Morvay Z, Oláh A, Párniczky A, Rubovszky G, Sahin-Tóth M, Szentkereszti Z, Szücs Á, Takács T, Tiszlavicz L, Pap Á. [Pancreatic cancer. Evidence based management guidelines of the Hungarian Pancreatic Study Group]. Orv Hetil. 2015 Feb 22; 156(8):326-39. PMID: 25662149; DOI: 10.1556/OH.2015.30063;

Hritz I, Czakó L, Dubravcsik Z, Farkas G, Kelemen D, Lásztity N, Morvay Z, Oláh A, Pap Á, Párniczky A, Sahin-Tóth M, Szentkereszti Z, Szmola R, Szücs Á, Takács T, Tiszlavicz L, Hegyi P. [Acute pancreatitis. Evidence-based practice guidelines, prepared by the Hungarian Pancreatic Study Group]. Orv Hetil. 2015 Feb 15; 156(7):244-61. PMID: 25661970; DOI: 10.1556/OH.2015.30059;

Takács T, Czakó L, Dubravcsik Z, Farkas G, Hegyi P, Hritz I, Kelemen D, Lásztity N, Morvay Z, Oláh A, Pap Á, Párniczky A, Patai Á, Sahin-Tóth M, Szentkereszti Z, Szmola R, Tiszlavicz L, Szücs Á. [Chronic pancreatitis. Evidence based management guidelines of the Hungarian Pancreatic Study Group]. Orv Hetil. 2015 Feb 15; 156(7):262-88. PMID: 25661971; DOI: 10.1556/OH.2015.30060;

Maléth J, Balázs A, Pallagi P, Balla Z, Kui B, Katona M, Judák L, Németh I, Kemény LV, Rakonczay Z, Venglovecz V, Földesi I, Peto Z, Somorácz Á, Borka K, Perdomo D, Lukacs GL, Gray MA, Monterisi S, Zaccolo M, Sendler M, Mayerle J, Kühn JP, Lerch MM, Sahin-Tóth M, Hegyi P. Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis. Gastroenterology. 2015 Feb; 148(2):427-39.e16. PMID: 25447846; PMCID: PMC4353632; DOI: 10.1053/j.gastro.2014.11.002;

Freeman M, Pandol SJ, Liddle RA, Saluja AK, Fernandez-Del Castillo C, Maitra A, Sahin-Toth M, Go VL. Minutes of the business meeting of the american pancreatic association, friday, november 1, 2013, miami, Florida. Pancreas. 2014 Nov; 43(8):1141-2. PMID: 25333397; DOI: 10.1097/MPA.0000000000000227;

Szabó A, Salameh MA, Ludwig M, Radisky ES, Sahin-Tóth M. Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids. PLoS One. 2014; 9(7):e102063. PMID: 25010489; PMCID: PMC4092071; DOI: 10.1371/journal.pone.0102063;

Németh BC, Sahin-Tóth M. Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Mar; 306(6):G466-73. PMID: 24458023; PMCID: PMC3949028; DOI: 10.1152/ajpgi.00419.2013;

Szabó A, Radisky ES, Sahin-Tóth M. Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation. J Biol Chem. 2014 Feb 21; 289(8):4753-61. PMID: 24403079; PMCID: PMC3931037; DOI: 10.1074/jbc.M113.538884;

Beer S, Sahin-Tóth M. Exonic variants affecting pre-mRNA splicing add to genetic burden in chronic pancreatitis. Gut. 2014 May; 63(5):860-1.View Related Profiles.

Sahin-Toth, Miklos
Beer, Sebastian

PMID: 24052272; PMCID: PMC3960364; DOI: 10.1136/gutjnl-2013-305981;

Witt H, Beer S, Rosendahl J, Chen JM, Chandak GR, Masamune A, Bence M, Szmola R, Oracz G, Macek M, Bhatia E, Steigenberger S, Lasher D, Bühler F, Delaporte C, Tebbing J, Ludwig M, Pilsak C, Saum K, Bugert P, Masson E, Paliwal S, Bhaskar S, Sobczynska-Tomaszewska A, Bak D, Balascak I, Choudhuri G, Nageshwar Reddy D, Rao GV, Thomas V, Kume K, Nakano E, Kakuta Y, Shimosegawa T, Durko L, Szabó A, Schnúr A, Hegyi P, Rakonczay Z, Pfützer R, Schneider A, Groneberg DA, Braun M, Schmidt H, Witt U, Friess H, Algül H, Landt O, Schuelke M, Krüger R, Wiedenmann B, Schmidt F, Zimmer KP, Kovacs P, Stumvoll M, Blüher M, Müller T, Janecke A, Teich N, Grützmann R, Schulz HU, Mössner J, Keim V, Löhr M, Férec C, Sahin-Tóth M. Variants in CPA1 are strongly associated with early onset chronic pancreatitis. Nat Genet. 2013 Oct; 45(10):1216-20.View Related Profiles.

Schnur, Andrea
Sahin-Toth, Miklos
Beer, Sebastian

PMID: 23955596; PMCID: PMC3909499; DOI: 10.1038/ng.2730;

Németh BC, Wartmann T, Halangk W, Sahin-Tóth M. Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop. J Biol Chem. 2013 Aug 16; 288(33):24049-62. PMID: 23814066; PMCID: PMC3745349; DOI: 10.1074/jbc.M113.478800;

Geisz A, Hegyi P, Sahin-Tóth M. Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants. FEBS J. 2013 Jun; 280(12):2888-99.View Related Profiles.

Geisz, Andrea
Sahin-Toth, Miklos

PMID: 23601753; PMCID: PMC3676443; DOI: 10.1111/febs.12292;

Schnúr A, Beer S, Witt H, Hegyi P, Sahin-Tóth M. Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis. Gut. 2014 Feb; 63(2):337-43.View Related Profiles.

Schnur, Andrea
Sahin-Toth, Miklos
Beer, Sebastian

PMID: 23455445; PMCID: PMC3681892; DOI: 10.1136/gutjnl-2012-304331;

Batra J, Szabó A, Caulfield TR, Soares AS, Sahin-Tóth M, Radisky ES. Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation. J Biol Chem. 2013 Apr 05; 288(14):9848-59. PMID: 23430245; PMCID: PMC3617285; DOI: 10.1074/jbc.M113.457382;

Szabó A, Sahin-Tóth M. Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen. FEBS J. 2012 Dec; 279(23):4283-92. PMID: 23035638; PMCID: PMC3573857; DOI: 10.1111/febs.12018;

Beer S, Zhou J, Szabó A, Keiles S, Chandak GR, Witt H, Sahin-Tóth M. Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk. Gut. 2013 Nov; 62(11):1616-24.View Related Profiles.

Zhou, Jiayi
Sahin-Toth, Miklos
Beer, Sebastian

PMID: 22942235; PMCID: PMC3660471; DOI: 10.1136/gutjnl-2012-303090;

Szabó A, Sahin-Tóth M. Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C. J Biol Chem. 2012 Jun 08; 287(24):20701-10. PMID: 22539344; PMCID: PMC3370252; DOI: 10.1074/jbc.M112.360065;

Bence M, Sahin-Tóth M. Asparagine-linked glycosylation of human chymotrypsin C is required for folding and secretion but not for enzyme activity. FEBS J. 2011 Nov; 278(22):4338-50. PMID: 21920023; PMCID: PMC3209518; DOI: 10.1111/j.1742-4658.2011.08351.x;

Pallagi P, Venglovecz V, Rakonczay Z, Borka K, Korompay A, Ozsvári B, Judák L, Sahin-Tóth M, Geisz A, Schnúr A, Maléth J, Takács T, Gray MA, Argent BE, Mayerle J, Lerch MM, Wittmann T, Hegyi P. Trypsin reduces pancreatic ductal bicarbonate secretion by inhibiting CFTR Cl? channels and luminal anion exchangers. Gastroenterology. 2011 Dec; 141(6):2228-2239.e6.View Related Profiles.

Geisz, Andrea
Schnur, Andrea
Sahin-Toth, Miklos

PMID: 21893120; PMCID: PMC3273991; DOI: 10.1053/j.gastro.2011.08.039;

Lacruz RS, Smith CE, Smith SM, Hu P, Bringas P, Sahin-Tóth M, Moradian-Oldak J, Paine ML. Chymotrypsin C (caldecrin) is associated with enamel development. J Dent Res. 2011 Oct; 90(10):1228-33. PMID: 21828354; PMCID: PMC3173010; DOI: 10.1177/0022034511418231;

Zhou J, Sahin-Tóth M. Chymotrypsin C mutations in chronic pancreatitis. J Gastroenterol Hepatol. 2011 Aug; 26(8):1238-46.View Related Profiles.

Zhou, Jiayi
Sahin-Toth, Miklos

PMID: 21631589; PMCID: PMC3142265; DOI: 10.1111/j.1440-1746.2011.06791.x;

Joergensen MT, Geisz A, Brusgaard K, Schaffalitzky de Muckadell OB, Hegyi P, Gerdes AM, Sahin-Tóth M. Intragenic duplication: a novel mutational mechanism in hereditary pancreatitis. Pancreas. 2011 May; 40(4):540-6.View Related Profiles.

Geisz, Andrea
Sahin-Toth, Miklos

PMID: 21499207; PMCID: PMC3088488; DOI: 10.1097/MPA.0b013e3182152fdf;

Szabó A, Héja D, Szakács D, Zboray K, Kékesi KA, Radisky ES, Sahin-Tóth M, Pál G. High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues. J Biol Chem. 2011 Jun 24; 286(25):22535-45. PMID: 21515688; PMCID: PMC3121398; DOI: 10.1074/jbc.M111.235754;

Király O, Guan L, Sahin-Tóth M. Expression of recombinant proteins with uniform N-termini. Methods Mol Biol. 2011; 705:175-94. PMID: 21125386; PMCID: PMC3107599; DOI: 10.1007/978-1-61737-967-3_10;

Szmola R, Bence M, Carpentieri A, Szabó A, Costello CE, Samuelson J, Sahin-Tóth M. Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2. J Biol Chem. 2011 Jan 21; 286(3):1819-27.View Related Profiles.

Costello, Catherine
Samuelson, John
Sahin-Toth, Miklos

PMID: 21098023; PMCID: PMC3023477; DOI: 10.1074/jbc.M110.187369;

Rosendahl J, Teich N, Kovacs P, Szmola R, Blüher M, Gress TM, Hoffmeister A, Keim V, Löhr M, Mössner J, Nickel R, Ockenga J, Pfützer R, Schulz HU, Stumvoll M, Wittenburg H, Sahin-Tóth M, Witt H. Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis. Pancreatology. 2010; 10(2-3):243-9. PMID: 20484962; PMCID: PMC2899151; DOI: 10.1159/000243769;

Rosendahl J, Rónai Z, Kovacs P, Teich N, Wittenburg H, Blüher M, Stumvoll M, Mössner J, Keim V, Bradbury AR, Sahin-Tóth M. Sequence analysis of the human tyrosylprotein sulfotransferase-2 gene in subjects with chronic pancreatitis. Pancreatology. 2010; 10(2-3):165-72. PMID: 20460947; PMCID: PMC2899149; DOI: 10.1159/000231979;

Szmola R, Sahin-Tóth M. Uncertainties in the classification of human cationic trypsinogen (PRSS1) variants as hereditary pancreatitis-associated mutations. J Med Genet. 2010 May; 47(5):348-50. PMID: 20452997; PMCID: PMC2930840; DOI: 10.1136/jmg.2009.072751;

Löhr JM, Faissner R, Koczan D, Bewerunge P, Bassi C, Brors B, Eils R, Frulloni L, Funk A, Halangk W, Jesenofsky R, Jesnowski R, Kaderali L, Kleeff J, Krüger B, Lerch MM, Lösel R, Magnani M, Neumaier M, Nittka S, Sahin-Tóth M, Sänger J, Serafini S, Schnölzer M, Thierse HJ, Wandschneider S, Zamboni G, Klöppel G. Autoantibodies against the exocrine pancreas in autoimmune pancreatitis: gene and protein expression profiling and immunoassays identify pancreatic enzymes as a major target of the inflammatory process. Am J Gastroenterol. 2010 Sep; 105(9):2060-71. PMID: 20407433; PMCID: PMC3099227; DOI: 10.1038/ajg.2010.141;

Szmola R, Sahin-Tóth M. Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells. Gut. 2010 Mar; 59(3):365-72. PMID: 19951900; PMCID: PMC2848392; DOI: 10.1136/gut.2009.198903;

Wartmann T, Mayerle J, Kähne T, Sahin-Tóth M, Ruthenbürger M, Matthias R, Kruse A, Reinheckel T, Peters C, Weiss FU, Sendler M, Lippert H, Schulz HU, Aghdassi A, Dummer A, Teller S, Halangk W, Lerch MM. Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice. Gastroenterology. 2010 Feb; 138(2):726-37. PMID: 19900452; PMCID: PMC2941736; DOI: 10.1053/j.gastro.2009.10.048;

Kereszturi E, Sahin-Tóth M. Intracellular autoactivation of human cationic trypsinogen mutants causes reduced trypsinogen secretion and acinar cell death. J Biol Chem. 2009 Nov 27; 284(48):33392-9. PMID: 19801634; PMCID: PMC2785183; DOI: 10.1074/jbc.M109.056812;

Weiss FU, Sahin-Tóth M. Variations in trypsinogen expression may influence the protective effect of the p.G191R PRSS2 variant in chronic pancreatitis. Gut. 2009 Jun; 58(6):749-50. PMID: 19433595; DOI: 10.1136/gut.2008.173039;

Medveczky P, Szmola R, Sahin-Tóth M. Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation. Biochem J. 2009 Jun 1; 420(2):335-43. PMID: 19254208; PMCID: PMC2750038; DOI: 10.1042/BJ20090005;

Kereszturi E, Szmola R, Kukor Z, Simon P, Weiss FU, Lerch MM, Sahin-Tóth M. Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism. Hum Mutat. 2009 Apr; 30(4):575-82. PMID: 19191323; PMCID: PMC2663013; DOI: 10.1002/humu.20853;

Rónai Z, Witt H, Rickards O, Destro-Bisol G, Bradbury AR, Sahin-Tóth M. A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2). Biochem J. 2009 Feb 15; 418(1):155-61. PMID: 18986305; PMCID: PMC2700036; DOI: 10.1042/BJ20081848;

Kereszturi E, Király O, Sahin-Tóth M. Minigene analysis of intronic variants in common SPINK1 haplotypes associated with chronic pancreatitis. Gut. 2009 Apr; 58(4):545-9. PMID: 18978175; PMCID: PMC2677899; DOI: 10.1136/gut.2008.164947;

Sahin-Tóth M, Hegyi P, Tóth M. [Genetic risk factors in chronic pancreatitis]. Orv Hetil. 2008 Sep 7; 149(36):1683-8. PMID: 18755660; DOI: 10.1556/OH.2008.28441;

Ozsvári B, Hegyi P, Sahin-Tóth M. The guinea pig pancreas secretes a single trypsinogen isoform, which is defective in autoactivation. Pancreas. 2008 Aug; 37(2):182-8. PMID: 18665081; PMCID: PMC2708092; DOI: 10.1097/MPA.0b013e3181663066;

Rosendahl J, Witt H, Szmola R, Bhatia E, Ozsvári B, Landt O, Schulz HU, Gress TM, Pfützer R, Löhr M, Kovacs P, Blüher M, Stumvoll M, Choudhuri G, Hegyi P, te Morsche RH, Drenth JP, Truninger K, Macek M, Puhl G, Witt U, Schmidt H, Büning C, Ockenga J, Kage A, Groneberg DA, Nickel R, Berg T, Wiedenmann B, Bödeker H, Keim V, Mössner J, Teich N, Sahin-Tóth M. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet. 2008 Jan; 40(1):78-82. PMID: 18059268; PMCID: PMC2650829; DOI: 10.1038/ng.2007.44;

Szmola R, Sahin-Tóth M. Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y. Proc Natl Acad Sci U S A. 2007 Jul 3; 104(27):11227-32. PMID: 17592142; PMCID: PMC2040881; DOI: 10.1073/pnas.0703714104;

Király O, Wartmann T, Sahin-Tóth M. Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation. Gut. 2007 Oct; 56(10):1433-8. PMID: 17525091; PMCID: PMC2000263; DOI: 10.1136/gut.2006.115725;

Király O, Boulling A, Witt H, Le Maréchal C, Chen JM, Rosendahl J, Battaggia C, Wartmann T, Sahin-Tóth M, Férec C. Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis. Hum Mutat. 2007 May; 28(5):469-76. PMID: 17274009; PMCID: PMC2765331; DOI: 10.1002/humu.20471;

Sahin-Tóth M, Kukor Z, Nemoda Z. Human cationic trypsinogen is sulfated on Tyr154. FEBS J. 2006 Nov; 273(22):5044-50. PMID: 17087724; PMCID: PMC2645268; DOI: 10.1111/j.1742-4658.2006.05501.x;

Wang Y, Luo W, Wartmann T, Halangk W, Sahin-Tóth M, Reiser G. Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes. J Neurochem. 2006 Nov; 99(3):759-69. PMID: 16903872; DOI: 10.1111/j.1471-4159.2006.04105.x;

Teich N, Rosendahl J, Tóth M, Mössner J, Sahin-Tóth M. Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis. Hum Mutat. 2006 Aug; 27(8):721-30. PMID: 16791840; PMCID: PMC2793115; DOI: 10.1002/humu.20343;

Szepessy E, Sahin-Tóth M. Human mesotrypsin exhibits restricted S1' subsite specificity with a strong preference for small polar side chains. FEBS J. 2006 Jul; 273(13):2942-54. PMID: 16759229; PMCID: PMC1550978; DOI: 10.1111/j.1742-4658.2006.05305.x;

Sahin-Tóth M. Biochemical models of hereditary pancreatitis. Endocrinol Metab Clin North Am. 2006 Jun; 35(2):303-12, ix. PMID: 16632094; PMCID: PMC1602208; DOI: 10.1016/j.ecl.2006.02.002;

Witt H, Sahin-Tóth M, Landt O, Chen JM, Kähne T, Drenth JP, Kukor Z, Szepessy E, Halangk W, Dahm S, Rohde K, Schulz HU, Le Maréchal C, Akar N, Ammann RW, Truninger K, Bargetzi M, Bhatia E, Castellani C, Cavestro GM, Cerny M, Destro-Bisol G, Spedini G, Eiberg H, Jansen JB, Koudova M, Rausova E, Macek M, Malats N, Real FX, Menzel HJ, Moral P, Galavotti R, Pignatti PF, Rickards O, Spicak J, Zarnescu NO, Böck W, Gress TM, Friess H, Ockenga J, Schmidt H, Pfützer R, Löhr M, Simon P, Weiss FU, Lerch MM, Teich N, Keim V, Berg T, Wiedenmann B, Luck W, Groneberg DA, Becker M, Keil T, Kage A, Bernardova J, Braun M, Güldner C, Halangk J, Rosendahl J, Witt U, Treiber M, Nickel R, Férec C. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. Nat Genet. 2006 Jun; 38(6):668-73. PMID: 16699518; PMCID: PMC2746914; DOI: 10.1038/ng1797;

Nemoda Z, Sahin-Tóth M. Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen. J Biol Chem. 2006 Apr 28; 281(17):11879-86. PMID: 16505482; PMCID: PMC1586167; DOI: 10.1074/jbc.M600124200;

Király O, Guan L, Szepessy E, Tóth M, Kukor Z, Sahin-Tóth M. Expression of human cationic trypsinogen with an authentic N terminus using intein-mediated splicing in aminopeptidase P deficient Escherichia coli. Protein Expr Purif. 2006 Jul; 48(1):104-11. PMID: 16542853; PMCID: PMC1604731; DOI: 10.1016/j.pep.2006.01.023;

Szepessy E, Sahin-Tóth M. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. Pancreatology. 2006; 6(1-2):117-22. PMID: 16327289; PMCID: PMC1447606; DOI: 10.1159/000090031;

Grishina Z, Ostrowska E, Halangk W, Sahin-Tóth M, Reiser G. Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1, -2, but weakly activates brain PAR-1. Br J Pharmacol. 2005 Dec; 146(7):990-9. PMID: 16231009; PMCID: PMC1751236; DOI: 10.1038/sj.bjp.0706410;

Sahin-Tóth M. Human mesotrypsin defies natural trypsin inhibitors: from passive resistance to active destruction. Protein Pept Lett. 2005 Jul; 12(5):457-64. PMID: 16029158; PMCID: PMC1488880

Nemoda Z, Sahin-Tóth M. The tetra-aspartate motif in the activation peptide of human cationic trypsinogen is essential for autoactivation control but not for enteropeptidase recognition. J Biol Chem. 2005 Aug 19; 280(33):29645-52. PMID: 15970597; PMCID: PMC1420407; DOI: 10.1074/jbc.M505661200;

Nemoda Z, Teich N, Hugenberg C, Sahin-Tóth M. Genetic and biochemical characterization of the E32del polymorphism in human mesotrypsinogen. Pancreatology. 2005; 5(2-3):273-8. PMID: 15855826; PMCID: PMC1401494; DOI: 10.1159/000085282;

Teich N, Nemoda Z, Köhler H, Heinritz W, Mössner J, Keim V, Sahin-Tóth M. Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl. Hum Mutat. 2005 Apr; 25(4):343-7. PMID: 15776435; PMCID: PMC2752332; DOI: 10.1002/humu.20148;

Teich N, Le Maréchal C, Kukor Z, Caca K, Witzigmann H, Chen JM, Tóth M, Mössner J, Keim V, Férec C, Sahin-Tóth M. Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2). Hum Mutat. 2004 Jan; 23(1):22-31. PMID: 14695529; DOI: 10.1002/humu.10285;

Szmola R, Kukor Z, Sahin-Tóth M. Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors. J Biol Chem. 2003 Dec 5; 278(49):48580-9. PMID: 14507909; PMCID: PMC1393292

Chen JM, Kukor Z, Le Maréchal C, Tóth M, Tsakiris L, Raguénès O, Férec C, Sahin-Tóth M. Evolution of trypsinogen activation peptides. Mol Biol Evol. 2003 Nov; 20(11):1767-77. PMID: 12832630; DOI: 10.1093/molbev/msg183;

Chen JM, Férec C, Sahin-Tóth M. Trypsinogen hL is not a new member of the human trypsinogen family, but a known mouse ortholog. Biol Pharm Bull. 2003 Jun; 26(6):909. PMID: 12808313

Kukor Z, Tóth M, Sahin-Tóth M. Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases. Eur J Biochem. 2003 May; 270(9):2047-58. PMID: 12709065

Guan L, Sahin-Tóth M, Kálai T, Hideg K, Kaback HR. Probing the mechanism of a membrane transport protein with affinity inactivators. J Biol Chem. 2003 Mar 21; 278(12):10641-8. PMID: 12471022; DOI: 10.1074/jbc.M211355200;

Sahin-Tóth M, Gunawan P, Lawrence MC, Toyokuni T, Kaback HR. Binding of hydrophobic D-galactopyranosides to the lactose permease of Escherichia coli. Biochemistry. 2002 Oct 29; 41(43):13039-45. PMID: 12390031

Guan L, Sahin-Toth M, Kaback HR. Changing the lactose permease of Escherichia coli into a galactose-specific symporter. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6613-8. PMID: 12011425; PMCID: PMC124451

Kukor Z, Mayerle J, Krüger B, Tóth M, Steed PM, Halangk W, Lerch MM, Sahin-Tóth M. Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis. J Biol Chem. 2002 Jun 14; 277(24):21389-96. PMID: 11932257; DOI: 10.1074/jbc.M200878200;

Simon P, Weiss FU, Sahin-Toth M, Parry M, Nayler O, Lenfers B, Schnekenburger J, Mayerle J, Domschke W, Lerch MM. Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --> Cys) that alters autoactivation and autodegradation of cationic trypsinogen. J Biol Chem. 2002 Feb 15; 277(7):5404-10. PMID: 11719509

Sahin-Toth M, Kaback HR. Arg-302 facilitates deprotonation of Glu-325 in the transport mechanism of the lactose permease from Escherichiacoli. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6068-73. PMID: 11353849; PMCID: PMC33423

Sahin-Tóth M. The pathobiochemistry of hereditary pancreatitis: studies on recombinant human cationic trypsinogen. Pancreatology. 2001; 1(5):461-5. PMID: 12120225

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