Keywords
Last Name

Ruslan Afasizhev, PhD

TitleProfessor
InstitutionBoston University Henry M. Goldman School of Dental Medicine
DepartmentMolecular & Cell Biology
Phone(617) 414-1055
ORCID ORCID Icon0000-0002-4595-6618
 NIH RePORTER Grants

Yr Title Project-Sub Proj Pubs
2016 Functional definition of guide RNAs 5R21AI115223-02
2016 Guide RNA Binding Complex 4R01AI101057-06 3
2016 Structures and Functions of RNA Editing TUTases 2R01AI091914-07A1 7
2015 Functional definition of guide RNAs 1R21AI115223-01
2015 Structures and Functions of RNA Editing TUTases 5R01AI091914-06 7
2014 Guide RNA Binding Complex 5R01AI101057-04 3
2014 Structures and Functions of RNA Editing TUTases 5R01AI091914-05 7
2013 Guide RNA Binding Complex 5R01AI101057-03 3
2013 Structures and Functions of RNA Editing TUTases 5R01AI091914-03 7
2013 Structures and Functions of RNA Editing TUTases 7R01AI091914-04 7
Showing the 10 most recent of 25 results. Show All Results

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Aphasizheva I, Zhang L, Aphasizhev R. Investigating RNA editing factors from trypanosome mitochondria. Methods. 2016 Sep 01; 107:23-33. PMID: 27020893.
    View in: PubMed
  2. Suematsu T, Zhang L, Aphasizheva I, Monti S, Huang L, Wang Q, Costello CE, Aphasizhev R. Antisense Transcripts Delimit Exonucleolytic Activity of the Mitochondrial 3' Processome to Generate Guide RNAs. Mol Cell. 2016 Feb 4; 61(3):364-78. PMID: 26833087.
    View in: PubMed
  3. Aphasizheva I, Maslov DA, Qian Y, Huang L, Wang Q, Costello CE, Aphasizhev R. Ribosome-associated pentatricopeptide repeat proteins function as translational activators in mitochondria of trypanosomes. Mol Microbiol. 2016 Mar; 99(6):1043-58. PMID: 26713541.
    View in: PubMed
  4. Aphasizheva I, Aphasizhev R. U-Insertion/Deletion mRNA-Editing Holoenzyme: Definition in Sight. Trends Parasitol. 2016 Feb; 32(2):144-56. PMID: 26572691.
    View in: PubMed
  5. Wong RG, Kazane K, Maslov DA, Rogers K, Aphasizhev R, Simpson L. U-insertion/deletion RNA editing multiprotein complexes and mitochondrial ribosomes in Leishmania tarentolae are located in antipodal nodes adjacent to the kinetoplast DNA. Mitochondrion. 2015 Nov; 25:76-86. PMID: 26462764.
    View in: PubMed
  6. Aphasizheva I, Zhang L, Wang X, Kaake RM, Huang L, Monti S, Aphasizhev R. RNA binding and core complexes constitute the U-insertion/deletion editosome. Mol Cell Biol. 2014 Dec 1; 34(23):4329-42. PMID: 25225332.
    View in: PubMed
  7. Aphasizhev R, Aphasizheva I. Mitochondrial RNA editing in trypanosomes: small RNAs in control. Biochimie. 2014 May; 100:125-31. PMID: 24440637.
    View in: PubMed
  8. Aphasizheva I, Maslov DA, Aphasizhev R. Kinetoplast DNA-encoded ribosomal protein S12: a possible functional link between mitochondrial RNA editing and translation in Trypanosoma brucei. RNA Biol. 2013 Nov; 10(11):1679-88. PMID: 24270388.
    View in: PubMed
  9. Aphasizhev R, Aphasizheva I. Emerging roles of PPR proteins in trypanosomes: switches, blocks, and triggers. RNA Biol. 2013; 10(9):1495-500. PMID: 24055869.
    View in: PubMed
  10. Aphasizhev R, Aphasizheva I. Mitochondrial RNA processing in trypanosomes. Res Microbiol. 2011 Sep; 162(7):655-63. PMID: 21596134.
    View in: PubMed
  11. Aphasizheva I, Maslov D, Wang X, Huang L, Aphasizhev R. Pentatricopeptide repeat proteins stimulate mRNA adenylation/uridylation to activate mitochondrial translation in trypanosomes. Mol Cell. 2011 Apr 8; 42(1):106-17. PMID: 21474072.
    View in: PubMed
  12. Aphasizhev R, Aphasizheva I. Uridine insertion/deletion editing in trypanosomes: a playground for RNA-guided information transfer. Wiley Interdiscip Rev RNA. 2011 Sep-Oct; 2(5):669-85. PMID: 21823228.
    View in: PubMed
  13. Ringpis GE, Lathrop RH, Aphasizhev R. iCODA: RNAi-based inducible knock-in system in Trypanosoma brucei. Methods Mol Biol. 2011; 718:23-37. PMID: 21370040.
    View in: PubMed
  14. Ringpis GE, Stagno J, Aphasizhev R. Mechanism of U-insertion RNA editing in trypanosome mitochondria: characterization of RET2 functional domains by mutational analysis. J Mol Biol. 2010 Jun 25; 399(5):696-706. PMID: 20417643.
    View in: PubMed
  15. Stagno J, Aphasizheva I, Bruystens J, Luecke H, Aphasizhev R. Structure of the mitochondrial editosome-like complex associated TUTase 1 reveals divergent mechanisms of UTP selection and domain organization. J Mol Biol. 2010 Jun 11; 399(3):464-75. PMID: 20403364.
    View in: PubMed
  16. Ringpis GE, Aphasizheva I, Wang X, Huang L, Lathrop RH, Hatfield GW, Aphasizhev R. Mechanism of U insertion RNA editing in trypanosome mitochondria: the bimodal TUTase activity of the core complex. J Mol Biol. 2010 Jun 25; 399(5):680-95. PMID: 20362585.
    View in: PubMed
  17. Aphasizheva I, Aphasizhev R. RET1-catalyzed uridylylation shapes the mitochondrial transcriptome in Trypanosoma brucei. Mol Cell Biol. 2010 Mar; 30(6):1555-67. PMID: 20086102.
    View in: PubMed
  18. Simpson L, Aphasizhev R, Lukes J, Cruz-Reyes J. Guide to the nomenclature of kinetoplastid RNA editing: a proposal. Protist. 2010 Jan; 161(1):2-6. PMID: 19945343.
    View in: PubMed
  19. Aphasizheva I, Ringpis GE, Weng J, Gershon PD, Lathrop RH, Aphasizhev R. Novel TUTase associates with an editosome-like complex in mitochondria of Trypanosoma brucei. RNA. 2009 Jul; 15(7):1322-37. PMID: 19465686.
    View in: PubMed
  20. Etheridge RD, Clemens DM, Gershon PD, Aphasizhev R. Identification and characterization of nuclear non-canonical poly(A) polymerases from Trypanosoma brucei. Mol Biochem Parasitol. 2009 Mar; 164(1):66-73. PMID: 19070634.
    View in: PubMed
  21. Weng J, Aphasizheva I, Etheridge RD, Huang L, Wang X, Falick AM, Aphasizhev R. Guide RNA-binding complex from mitochondria of trypanosomatids. Mol Cell. 2008 Oct 24; 32(2):198-209. PMID: 18951088.
    View in: PubMed
  22. Etheridge RD, Aphasizheva I, Gershon PD, Aphasizhev R. 3' adenylation determines mRNA abundance and monitors completion of RNA editing in T. brucei mitochondria. EMBO J. 2008 Jun 4; 27(11):1596-608. PMID: 18464794.
    View in: PubMed
  23. Aphasizhev R, Aphasizheva I. Terminal RNA uridylyltransferases of trypanosomes. Biochim Biophys Acta. 2008 Apr; 1779(4):270-80. PMID: 18191648.
    View in: PubMed
  24. Stagno J, Aphasizheva I, Aphasizhev R, Luecke H. Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14634-9. PMID: 17785418.
    View in: PubMed
  25. Afasizhev R. [RNA editing]. Mol Biol (Mosk). 2007 Mar-Apr; 41(2):260-73. PMID: 17514895.
    View in: PubMed
  26. Pelletier M, Read LK, Aphasizhev R. Isolation of RNA binding proteins involved in insertion/deletion editing. Methods Enzymol. 2007; 424:75-105. PMID: 17662837.
    View in: PubMed
  27. Aphasizhev R, Aphasizheva I. RNA editing uridylyltransferases of trypanosomatids. Methods Enzymol. 2007; 424:55-73. PMID: 17662836.
    View in: PubMed
  28. Stagno J, Aphasizheva I, Rosengarth A, Luecke H, Aphasizhev R. UTP-bound and Apo structures of a minimal RNA uridylyltransferase. J Mol Biol. 2007 Feb 23; 366(3):882-99. PMID: 17189640.
    View in: PubMed
  29. Aphasizhev R. RNA uridylyltransferases. Cell Mol Life Sci. 2005 Oct; 62(19-20):2194-203. PMID: 16158189.
    View in: PubMed
  30. Aphasizhev R, Aphasizheva I, Simpson L. Multiple terminal uridylyltransferases of trypanosomes. FEBS Lett. 2004 Aug 13; 572(1-3):15-8. PMID: 15304317.
    View in: PubMed
  31. Aphasizheva I, Aphasizhev R, Simpson L. RNA-editing terminal uridylyl transferase 1: identification of functional domains by mutational analysis. J Biol Chem. 2004 Jun 4; 279(23):24123-30. PMID: 15060068.
    View in: PubMed
  32. Simpson L, Aphasizhev R, Gao G, Kang X. Mitochondrial proteins and complexes in Leishmania and Trypanosoma involved in U-insertion/deletion RNA editing. RNA. 2004 Feb; 10(2):159-70. PMID: 14730014.
    View in: PubMed
  33. Kang X, Falick AM, Nelson RE, Gao G, Rogers K, Aphasizhev R, Simpson L. Disruption of the zinc finger motifs in the Leishmania tarentolae LC-4 (=TbMP63) L-complex editing protein affects the stability of the L-complex. J Biol Chem. 2004 Feb 6; 279(6):3893-9. PMID: 14604987.
    View in: PubMed
  34. Aphasizhev R, Aphasizheva I, Simpson L. A tale of two TUTases. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10617-22. PMID: 12954983.
    View in: PubMed
  35. Simpson L, Sbicego S, Aphasizhev R. Uridine insertion/deletion RNA editing in trypanosome mitochondria: a complex business. RNA. 2003 Mar; 9(3):265-76. PMID: 12591999.
    View in: PubMed
  36. Aphasizhev R, Aphasizheva I, Nelson RE, Gao G, Simpson AM, Kang X, Falick AM, Sbicego S, Simpson L. Isolation of a U-insertion/deletion editing complex from Leishmania tarentolae mitochondria. EMBO J. 2003 Feb 17; 22(4):913-24. PMID: 12574127.
    View in: PubMed
  37. Aphasizhev R, Aphasizheva I, Nelson RE, Simpson L. A 100-kD complex of two RNA-binding proteins from mitochondria of Leishmania tarentolae catalyzes RNA annealing and interacts with several RNA editing components. RNA. 2003 Jan; 9(1):62-76. PMID: 12554877.
    View in: PubMed
  38. Aphasizhev R, Sbicego S, Peris M, Jang SH, Aphasizheva I, Simpson AM, Rivlin A, Simpson L. Trypanosome mitochondrial 3' terminal uridylyl transferase (TUTase): the key enzyme in U-insertion/deletion RNA editing. Cell. 2002 Mar 8; 108(5):637-48. PMID: 11893335.
    View in: PubMed
  39. Aphasizhev R, Simpson L. Isolation and characterization of a U-specific 3'-5'-exonuclease from mitochondria of Leishmania tarentolae. J Biol Chem. 2001 Jun 15; 276(24):21280-4. PMID: 11279235.
    View in: PubMed
  40. Blanc V, Alfonzo JD, Aphasizhev R, Simpson L. The mitochondrial RNA ligase from Leishmania tarentolae can join RNA molecules bridged by a complementary RNA. J Biol Chem. 1999 Aug 20; 274(34):24289-96. PMID: 10446205.
    View in: PubMed
  41. Aphasizhev R, Karmarkar U, Simpson L. Are tRNAs imported into the mitochondria of kinetoplastid protozoa as 5'-extended precursors? Mol Biochem Parasitol. 1998 May 15; 93(1):73-80. PMID: 9662029.
    View in: PubMed
  42. Aphasizhev R, Théobald-Dietrich A, Kostyuk D, Kochetkov SN, Kisselev L, Giegé R, Fasiolo F. Structure and aminoacylation capacities of tRNA transcripts containing deoxyribonucleotides. RNA. 1997 Aug; 3(8):893-904. PMID: 9257648.
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  43. Aphasizhev R, Senger B, Fasiolo F. Importance of structural features for tRNA(Met) identity. RNA. 1997 May; 3(5):489-97. PMID: 9149230.
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  44. Aphasizhev R, Senger B, Rengers JU, Sprinzl M, Walter P, Nussbaum G, Fasiolo F. Conservation in evolution for a small monomeric phenylalanyl-tRNA synthetase of the tRNA(Phe) recognition nucleotides and initial aminoacylation site. Biochemistry. 1996 Jan 9; 35(1):117-23. PMID: 8555164.
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  45. Senger B, Aphasizhev R, Walter P, Fasiolo F. The presence of a D-stem but not a T-stem is essential for triggering aminoacylation upon anticodon binding in yeast methionine tRNA. J Mol Biol. 1995 May 26; 249(1):45-58. PMID: 7776375.
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  46. Aphasizhev R, Beresten S, Pugachev V, Kisselev L. Random-splitting of tRNA transcripts as an approach for studying tRNA-protein interactions. FEBS Lett. 1993 May 24; 323(1-2):175-8. PMID: 8495735.
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