Ruslan Afasizhev, PhD
Professor
Boston University Henry M. Goldman School of Dental Medicine
Molecular & Cell Biology

PhD, Russian Academy of Medical Sciences
MS, Moscow State University
BA, Moscow State University



Ruslan Afasizhev PhD, is a Professor of Molecular and Cell Biology at the Boston University Goldman School of Dental Medicine. With funding from six fellowships including those from FEBS , EMBO, and CNRS-Russian Academy of Sciences Program, he received postdoctoral training at the Howard Hughes Medical Institute of the University of California, Los Angeles. He has published over 40 papers in the field of Biology and runs a lab where he is broadly interested in molecular mechanisms of RNA processing in Trypanosoma brucei spp. He is a current member of the American Society for Microbiology and the RNA Society.

Professor
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Mitochondrial RNA Uridylation in Trypanosomes
02/21/2024 - 12/31/2028 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R01AI177658-01A1

Decoding the mitochondrial proteomes of six pathogenic protozoa
11/01/2022 - 10/31/2025 (PI)
Howard Hughes Medical Institute


TRANSCRIPTIONAL CONTROL OF MITOCHONDRIAL GENE EXPRESSION IN TRYPANOSOMES
07/13/2020 - 06/30/2025 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI152408-04

Guide RNA binding complex
07/05/2017 - 06/30/2024 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI101057-11

RNA Uridylation in Trypanosomes
05/05/2022 - 04/30/2024 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R56AI168191-01

Structures and Functions of RNA Editing TUTases
03/10/2016 - 02/28/2022 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI091914-11

Cytosolic mRNA Uridylation in Trypanosoma brucei
12/23/2016 - 11/30/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI128189-02

Boston University School of Medicine RNA Club
11/01/2017 - 10/31/2018 (Multi-PI)
PI: Ruslan Afasizhev, PhD
RNA Society


Guide RNA binding complex
05/01/2016 - 07/04/2017 (PI)
NIH/National Institute of Allergy & Infectious Diseases
4R01AI101057-06

Functional definition of guide RNAs
12/01/2014 - 11/30/2016 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI115223-02

Showing 10 of 12 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2024 Mitochondrial RNA Uridylation in Trypanosomes 1R01AI177658-01A1
2023 TRANSCRIPTIONAL CONTROL OF MITOCHONDRIAL GENE EXPRESSION IN TRYPANOSOMES 5R01AI152408-04
2022 RNA Uridylation in Trypanosomes 1R56AI168191-01
2022 TRANSCRIPTIONAL CONTROL OF MITOCHONDRIAL GENE EXPRESSION IN TRYPANOSOMES 5R01AI152408-03
2021 TRANSCRIPTIONAL CONTROL OF MITOCHONDRIAL GENE EXPRESSION IN TRYPANOSOMES 5R01AI152408-02
2021 Guide RNA Binding Complex 5R01AI101057-11 12
2020 TRANSCRIPTIONAL CONTROL OF MITOCHONDRIAL GENE EXPRESSION IN TRYPANOSOMES 1R01AI152408-01A1
2020 Guide RNA Binding Complex 5R01AI101057-10 12
2020 Structures and Functions of RNA Editing TUTases 5R01AI091914-11 14
2019 Guide RNA Binding Complex 5R01AI101057-09 12
Showing 10 of 42 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Zhang L, Sement FM, Suematsu T, Yu T, Monti S, Huang L, Aphasizhev R, Aphasizheva I. PPR polyadenylation factor defines mitochondrial mRNA identity and stability in trypanosomes. EMBO J. 2017 Aug 15; 36(16):2435-2454.View Related Profiles. PMID: 28684539; PMCID: PMC5556272; DOI: 10.15252/embj.201796808;
     
  2. Rajappa-Titu L, Suematsu T, Munoz-Tello P, Long M, Demir Ö, Cheng KJ, Stagno JR, Luecke H, Amaro RE, Aphasizheva I, Aphasizhev R, Thore S. RNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targeting. Nucleic Acids Res. 2016 Dec 15; 44(22):10862-10878.View Related Profiles. PMID: 27744351; PMCID: PMC5159558; DOI: 10.1093/nar/gkw917;
     
  3. Aphasizhev R, Suematsu T, Zhang L, Aphasizheva I. Constructive edge of uridylation-induced RNA degradation. RNA Biol. 2016 Nov; 13(11):1078-1083.View Related Profiles. PMID: 27715485; PMCID: PMC5100348; DOI: 10.1080/15476286.2016.1229736;
     
  4. Aphasizheva I, Zhang L, Aphasizhev R. Investigating RNA editing factors from trypanosome mitochondria. Methods. 2016 Sep 01; 107:23-33.View Related Profiles. PMID: 27020893; PMCID: PMC5094665; DOI: 10.1016/j.ymeth.2016.03.020;
     
  5. Suematsu T, Zhang L, Aphasizheva I, Monti S, Huang L, Wang Q, Costello CE, Aphasizhev R. Antisense Transcripts Delimit Exonucleolytic Activity of the Mitochondrial 3' Processome to Generate Guide RNAs. Mol Cell. 2016 Feb 4; 61(3):364-78.View Related Profiles. PMID: 26833087; PMCID: PMC4744118; DOI: 10.1016/j.molcel.2016.01.004;
     
  6. Aphasizheva I, Maslov DA, Qian Y, Huang L, Wang Q, Costello CE, Aphasizhev R. Ribosome-associated pentatricopeptide repeat proteins function as translational activators in mitochondria of trypanosomes. Mol Microbiol. 2016 Mar; 99(6):1043-58.View Related Profiles. PMID: 26713541; PMCID: PMC4855836; DOI: 10.1111/mmi.13287;
     
  7. Aphasizheva I, Aphasizhev R. U-Insertion/Deletion mRNA-Editing Holoenzyme: Definition in Sight. Trends Parasitol. 2016 Feb; 32(2):144-56.View Related Profiles. PMID: 26572691; PMCID: PMC4737982; DOI: 10.1016/j.pt.2015.10.004;
     
  8. Wong RG, Kazane K, Maslov DA, Rogers K, Aphasizhev R, Simpson L. U-insertion/deletion RNA editing multiprotein complexes and mitochondrial ribosomes in Leishmania tarentolae are located in antipodal nodes adjacent to the kinetoplast DNA. Mitochondrion. 2015 Nov; 25:76-86. PMID: 26462764; PMCID: PMC4671395; DOI: 10.1016/j.mito.2015.10.006;
     
  9. Aphasizheva I, Zhang L, Wang X, Kaake RM, Huang L, Monti S, Aphasizhev R. RNA binding and core complexes constitute the U-insertion/deletion editosome. Mol Cell Biol. 2014 Dec 1; 34(23):4329-42.View Related Profiles. PMID: 25225332; PMCID: PMC4248751; DOI: 10.1128/MCB.01075-14;
     
  10. Aphasizhev R, Aphasizheva I. Mitochondrial RNA editing in trypanosomes: small RNAs in control. Biochimie. 2014 May; 100:125-31.View Related Profiles. PMID: 24440637; PMCID: PMC4737708; DOI: 10.1016/j.biochi.2014.01.003;
     
Showing 10 of 49 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 49 publications over 22 distinct years, with a maximum of 5 publications in 2003 and 2007 and 2016

YearPublications
19931
19951
19961
19972
19981
19991
20011
20021
20035
20043
20051
20061
20075
20083
20092
20104
20114
20132
20142
20152
20165
20171

1996 HHMI post-doctoral fellowship
1995 EMBO post-doctoral fellowship
1994 FEBS/EMBO summer school: FEBS fellowship
1994 FEBS short-term fellowship
1993 CNRS-Russian Academy of Sciences Program: Fellowship
1993 FEBS advanced course: FEBS fellowship
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Biochemistry
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72 E. Concord St Evans Building
Boston MA 02118
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