Mitochondrial RNA Uridylation in Trypanosomes
02/21/2024 - 12/31/2028 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R01AI177658-01A1

Decoding the mitochondrial proteomes of six pathogenic protozoa
11/01/2022 - 10/31/2025 (PI)
Howard Hughes Medical Institute


TRANSCRIPTIONAL CONTROL OF MITOCHONDRIAL GENE EXPRESSION IN TRYPANOSOMES
07/13/2020 - 06/30/2025 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI152408-05

Guide RNA binding complex
07/05/2017 - 06/30/2024 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI101057-11

RNA Uridylation in Trypanosomes
05/05/2022 - 04/30/2024 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R56AI168191-01

Structures and Functions of RNA Editing TUTases
03/10/2016 - 02/28/2022 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI091914-11

Cytosolic mRNA Uridylation in Trypanosoma brucei
12/23/2016 - 11/30/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI128189-02

Boston University School of Medicine RNA Club
11/01/2017 - 10/31/2018 (Multi-PI)
PI: Ruslan Afasizhev, PhD
RNA Society


Guide RNA binding complex
05/01/2016 - 07/04/2017 (PI)
NIH/National Institute of Allergy & Infectious Diseases
4R01AI101057-06

Functional definition of guide RNAs
12/01/2014 - 11/30/2016 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI115223-02

Showing 10 of 12 results. Show All Results

1. Plaza-Pegueroles A, Aphasizheva I, Aphasizhev R, Fernández-Tornero C, Ruiz FM. The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function. Structure. 2024 Jul 11; 32(7):930-940.e3.View Related Profiles.

   Afasizheva, Inna
   Afasizhev, Ruslan
   

   PMID: 38593794; PMCID: PMC11246232; DOI: 10.1016/j.str.2024.03.010;
2. Liu S, Wang H, Li X, Zhang F, Lee JKJ, Li Z, Yu C, Hu JJ, Zhao X, Suematsu T, Alvarez-Cabrera AL, Liu Q, Zhang L, Huang L, Aphasizheva I, Aphasizhev R, Zhou ZH. Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing. Science. 2023 Jul 07; 381(6653):eadg4725.View Related Profiles.

   Afasizheva, Inna
   Afasizhev, Ruslan
   Suematsu, Takuma
   

   PMID: 37410820; PMCID: PMC10704856; DOI: 10.1126/science.adg4725;
3. Aphasizhev R, Aphasizheva I. A new class of antiparasitic drugs. Science. 2023 Jun 30; 380(6652):1320-1321.View Related Profiles.

   Afasizheva, Inna
   Afasizhev, Ruslan
   

   PMID: 37384682; PMCID: PMC10690620; DOI: 10.1126/science.adi5925;
4. Silveira d'Almeida G, Casius A, Henderson JC, Knuesel S, Aphasizhev R, Aphasizheva I, Manning AC, Lowe TM, Alfonzo JD. tRNATyr has an unusually short half-life in Trypanosoma brucei. RNA. 2023 Aug; 29(8):1243-1254.View Related Profiles.

   Afasizheva, Inna
   Afasizhev, Ruslan
   

   PMID: 37197826; PMCID: PMC10351884; DOI: 10.1261/rna.079674.123;
5. Lee JKJ, Liu YT, Hu JJ, Aphasizheva I, Aphasizhev R, Zhou ZH. CryoEM reveals oligomeric isomers of a multienzyme complex and assembly mechanics. J Struct Biol X. 2023; 7:100088.View Related Profiles.

   Afasizheva, Inna
   Afasizhev, Ruslan
   

   PMID: 37128595; PMCID: PMC10148081; DOI: 10.1016/j.yjsbx.2023.100088;
6. Hu JJ, Lee JKJ, Liu YT, Yu C, Huang L, Aphasizheva I, Aphasizhev R, Zhou ZH. Discovery, structure, and function of filamentous 3-methylcrotonyl-CoA carboxylase. Structure. 2023 Jan 05; 31(1):100-110.e4.View Related Profiles.

   Afasizheva, Inna
   Afasizhev, Ruslan
   

   PMID: 36543169; PMCID: PMC9825669; DOI: 10.1016/j.str.2022.11.015;
7. Aphasizheva I, Suematsu T, Vacas A, Wang H, Fan C, Zhao X, Zhang L, Aphasizhev R. CTS tag-based methods for investigating mitochondrial RNA modification factors in Trypanosoma brucei. Methods Enzymol. 2021; 658:83-109.View Related Profiles.

   Vacas, Andres
   Afasizheva, Inna
   Afasizhev, Ruslan
   Suematsu, Takuma
   

   PMID: 34517961; PMCID: PMC9805619; DOI: 10.1016/bs.mie.2021.06.004;
8. Aphasizheva I, Aphasizhev R. Mitochondrial RNA quality control in trypanosomes. Wiley Interdiscip Rev RNA. 2021 May; 12(3):e1638.View Related Profiles.

   Afasizheva, Inna
   Afasizhev, Ruslan
   

   PMID: 33331073; PMCID: PMC9805618; DOI: 10.1002/wrna.1638;
9. Aphasizheva I, Yu T, Suematsu T, Liu Q, Mesitov MV, Yu C, Huang L, Zhang L, Aphasizhev R. Poly(A) binding KPAF4/5 complex stabilizes kinetoplast mRNAs in Trypanosoma brucei. Nucleic Acids Res. 2020 09 04; 48(15):8645-8662.View Related Profiles.

   Afasizheva, Inna
   Liu, Qiushi
   Afasizhev, Ruslan
   Suematsu, Takuma
   

   PMID: 32614436; PMCID: PMC7470953; DOI: 10.1093/nar/gkaa575;
10. Aphasizheva I, Alfonzo J, Carnes J, Cestari I, Cruz-Reyes J, Göringer HU, Hajduk S, Lukeš J, Madison-Antenucci S, Maslov DA, McDermott SM, Ochsenreiter T, Read LK, Salavati R, Schnaufer A, Schneider A, Simpson L, Stuart K, Yurchenko V, Zhou ZH, Zíková A, Zhang L, Zimmer S, Aphasizhev R. Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes. Trends Parasitol. 2020 04; 36(4):337-355.View Related Profiles.

    Afasizheva, Inna
    Afasizhev, Ruslan
    

    PMID: 32191849; PMCID: PMC7083771; DOI: 10.1016/j.pt.2020.01.006;

Showing 10 of 60 results. Show More

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