Douglas L. Rosene, PhD
Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, University of Rochester



My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




COLLABORATIVE RESEARCH: UNRAVELING CEREBRAL CONNECTIVITY WITH DIFFUSION MRI, MICROSCOPY AND STATISTICAL PHYSICS
08/15/2015 - 07/31/2020 (Co-PI)
PI: H. Eugene Stanley, PhD
National Science Foundation
PHY-1505000

NEURAL SUBSTRATES OF DIFFUSION IMAGING IN COGNITIVELY AGING RHESUS MONKEYS
06/01/2016 - 05/31/2019 (PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-05

EFFECTS OF CURCUMIN ON FRONTAL CIRCUITRY IN AGING MONKEYS USING MRI CONNECTOME
05/01/2016 - 04/30/2019 (PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NCCIH
5R21AT008865-02

TRANSLATIONAL DEVELOPMENT OF GLIAL GROWTH FACTOR 2 (GGF2) FOR THE TREATMENT OF ST
09/01/2017 - 07/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
7U01NS076474-03

HISTOPATHOLOGY, NEUROIMAGING, AND MECHANISM OF MYELIN DAMAGE IN AGING MONKEY BRAIN
06/15/2016 - 04/30/2018 (PI)
NIH/National Institute on Aging
5R01AG043640-05

TRANSLATIONAL DEVELOPMENT OF GGF2 AS A STROKE RECOVERY THERAPEUTIC
08/01/2016 - 08/01/2017 (PI)
Acorda Therapeutics, Inc. NIH NINDS
5U01NS076474-02

NEURAL SUBSTRATES OF DIFFUSION IMAGING IN COGNITIVELY AGING RHESUS MONKEYS
09/15/2013 - 05/31/2016 (PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-03

HISTOPATHOLOGY, NEUROIMAGING, AND MECHANISM OF MYELIN DAMAGE IN AGING MONKEY BRAIN
08/01/2013 - 04/30/2016 (PI)
NIH/National Institute on Aging
5R01AG043640-03

THE HUMAN CONNECTOME PROJECT (HCP)
09/01/2013 - 08/31/2015 (PI)
Massachusetts General Hospital NIH NIMH
5U01MH093765-05

QUANTITATIVE ANALYSIS OF CEREBRAL CORTEX IN AGING MONKEYS
08/01/2008 - 07/31/2015 (Co-PI)
PI: H. Eugene Stanley, PhD
NIH/National Institute on Aging
5R01AG021133-08

Showing 10 of 20 results. Show All Results



Yr Title Project-Sub Proj Pubs
2017 Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St 7U01NS076474-03
2017 Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey Brain 5R01AG043640-05 4
2016 Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St 5U01NS076474-02
2016 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 4R01AG042512-04 7
2016 Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey Brain 4R01AG043640-04 4
2015 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 3R01AG042512-02S1 7
2014 Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St 1U01NS076474-01A1
2014 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-02 7
2014 Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey Brain 5R01AG043640-02 4
2014 Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey Brain 3R01AG043640-02S1 4
Showing 10 of 78 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Koo BB, Calderazzo S, Bowley BGE, Kolli A, Moss MB, Rosene DL, Moore TL. Long-term effects of curcumin in the non-human primate brain. Brain Res Bull. 2018 Sep; 142:88-95.View Related Profiles. PMID: 29981358.
     
  2. Kubicki M, Baxi M, Pasternak O, Tang Y, Karmacharya S, Chunga N, Lyall AE, Rathi Y, Eckbo R, Bouix S, Mortazavi F, Papadimitriou G, Shenton ME, Westin CF, Killiany R, Makris N, Rosene DL. Lifespan Trajectories of White Matter Changes in Rhesus Monkeys. Cereb Cortex. 2018 Apr 26.View Related Profiles. PMID: 29701751.
     
  3. Mortazavi F, Oblak AL, Morrison WZ, Schmahmann JD, Stanley HE, Wedeen VJ, Rosene DL. Geometric Navigation of Axons in a Cerebral Pathway: Comparing dMRI with Tract Tracing and Immunohistochemistry. Cereb Cortex. 2018 Apr 01; 28(4):1219-1232.View Related Profiles. PMID: 28203748; DOI: 10.1093/cercor/bhx034;.
     
  4. Orczykowski ME, Arndt KR, Palitz LE, Kramer BC, Pessina MA, Oblak AL, Finklestein SP, Mortazavi F, Rosene DL, Moore TL. Cell based therapy enhances activation of ventral premotor cortex to improve recovery following primary motor cortex injury. Exp Neurol. 2018 Jul; 305:13-25.View Related Profiles. PMID: 29540323.
     
  5. Moore TL, Bowley BGE, Shultz PL, Calderazzo SM, Shobin EJ, Uprety AR, Rosene DL, Moss MB. Oral curcumin supplementation improves fine motor function in the middle-aged rhesus monkey. Somatosens Mot Res. 2018 03; 35(1):1-10.View Related Profiles. PMID: 29447046.
     
  6. Seth N, Simmons HA, Masood F, Graham WA, Rosene DL, Westmoreland SV, Cummings SM, Gwardjan B, Sejdic E, Hoggatt AF, Schalk DR, Abdullah HA, Sledge JB, Nesathurai S. Model of Traumatic Spinal Cord Injury for Evaluating Pharmacologic Treatments in Cynomolgus Macaques (Macaca fasicularis). Comp Med. 2018 Feb 01; 68(1):63-73. PMID: 29460723.
     
  7. Robinson AA, Abraham CR, Rosene DL. Candidate molecular pathways of white matter vulnerability in the brain of normal aging rhesus monkeys. Geroscience. 2018 02; 40(1):31-47.View Related Profiles. PMID: 29357021.
     
  8. Paspalas CD, Carlyle BC, Leslie S, Preuss TM, Crimins JL, Huttner AJ, van Dyck CH, Rosene DL, Nairn AC, Arnsten AFT. The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology. Alzheimers Dement. 2018 May; 14(5):680-691. PMID: 29241829.
     
  9. Moore TL, Bowley B, Shultz P, Calderazzo S, Shobin E, Killiany RJ, Rosene DL, Moss MB. Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys. Geroscience. 2017 12; 39(5-6):571-584.View Related Profiles. PMID: 29047012.
     
  10. Mortazavi F, Romano SE, Rosene DL, Rockland KS. A Survey of White Matter Neurons at the Gyral Crowns and Sulcal Depths in the Rhesus Monkey. Front Neuroanat. 2017; 11:69.View Related Profiles. PMID: 28860975.
     
Showing 10 of 154 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 143 publications over 36 distinct years, with a maximum of 9 publications in 2003 and 2005

YearPublications
19801
19811
19822
19831
19841
19853
19861
19872
19884
19891
19902
19935
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19953
19963
19975
19983
19997
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20039
20048
20059
20067
20072
20087
20095
20103
20116
20128
20133
20143
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20163
20175
20187
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

histology
neural imaging
neural receptors
neuroanatomy
neurobiology
neurophysiology
neuropsychology
neurotransmitters
stereology

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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