Douglas L. Rosene, PhD
Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, University of Rochester




My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
08/15/2019 - 04/30/2024 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-07

Age-related cognitive decline and myelin pathology: A comprehensive study of oligodendroglia, microglia and myelin homeostasis in the normal aging monkey
05/15/2019 - 03/31/2024 (PI)
NIH/National Institute on Aging
1RF1AG062831-01

Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie Restriction
02/15/2019 - 01/31/2024 (PI)
NIH/National Institute on Aging
2RF1AG043640-06

White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys
02/01/2019 - 11/30/2021 (PI)
NIH/National Institute on Aging
5R21AG061678-02

Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity
04/01/2019 - 03/31/2021 (Multi-PI)
PI: Douglas L. Rosene, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R21NS111174-01

Collaborative Research: Unraveling Cerebral Connectivity with Diffusion MRI, Microscopy and Statistical Physics
08/15/2015 - 01/31/2021 (Co-PI)
National Science Foundation
PHY-1505000

Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
06/01/2016 - 05/31/2019 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-05

Effects of Curcumin on Frontal Circuitry in Aging Monkeys using MRI Connectome
05/01/2016 - 04/30/2019 (Subcontract PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NCCIH
5R21AT008865-02

Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St
09/01/2017 - 07/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
7U01NS076474-03

Histopathology, Neuroimaging, and Mechanism of Myelin Damage in Aging Monkey Brain
06/15/2016 - 04/30/2018 (PI)
NIH/National Institute on Aging
5R01AG043640-05

Showing 10 of 25 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2020 White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys 5R21AG061678-02
2020 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-07 40
2019 Age-related cognitive decline and myelin pathology: A comprehensive study of oligodendroglia, microglia and myelin homeostasis in the normal aging monkey 1RF1AG062831-01
2019 Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the Influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity 1R21NS111174-01 1
2019 White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys 1R21AG061678-01
2019 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 2R01AG042512-06 40
2019 Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie Restriction 2RF1AG043640-06
2017 Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St 7U01NS076474-03
2017 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-05 40
2017 Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey Brain 5R01AG043640-05 14
Showing 10 of 88 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Tsintou M, Dalamagkas K, Moore TL, Rathi Y, Kubicki M, Rosene DL, Makris N. The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke: a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches. Neural Regen Res. 2021 Apr; 16(4):605-613.View Related Profiles. PMID: 33063708
     
  2. Sanmarco LM, Wheeler MA, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ. Gut-licensed IFN?+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes. Nature. 2021 Jan 06. PMID: 33408417
     
  3. Rushmore RJ, McGaughy JA, Amaral AC, Mokler DJ, Morgane PJ, Galler JR, Rosene DL. The neural basis of attentional alterations in prenatally protein malnourished rats. Cereb Cortex. 2021 Jan 01; 31(1):497-512. PMID: 33099611
     
  4. Warren WC, Harris RA, Haukness M, Fiddes IT, Murali SC, Fernandes J, Dishuck PC, Storer JM, Raveendran M, Hillier LW, Porubsky D, Mao Y, Gordon D, Vollger MR, Lewis AP, Munson KM, DeVogelaere E, Armstrong J, Diekhans M, Walker JA, Tomlinson C, Graves-Lindsay TA, Kremitzki M, Salama SR, Audano PA, Escalona M, Maurer NW, Antonacci F, Mercuri L, Maggiolini FAM, Catacchio CR, Underwood JG, O'Connor DH, Sanders AD, Korbel JO, Ferguson B, Kubisch HM, Picker L, Kalin NH, Rosene D, Levine J, Abbott DH, Gray SB, Sanchez MM, Kovacs-Balint ZA, Kemnitz JW, Thomasy SM, Roberts JA, Kinnally EL, Capitanio JP, Skene JHP, Platt M, Cole SA, Green RE, Ventura M, Wiseman RW, Paten B, Batzer MA, Rogers J, Eichler EE. Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility. Science. 2020 12 18; 370(6523). PMID: 33335035
     
  5. Rushmore RJ, McGaughy JA, Mokler DJ, Rosene DL. The enduring effect of prenatal protein malnutrition on brain anatomy, physiology and behavior. Nutr Neurosci. 2020 Dec 14; 1-8. PMID: 33314995
     
  6. Go V, Sarikaya D, Zhou Y, Bowley BGE, Pessina MA, Rosene DL, Zhang ZG, Chopp M, Finklestein SP, Medalla M, Buller B, Moore TL. Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys. Exp Neurol. 2020 Nov 29; 337:113540.View Related Profiles. PMID: 33264634
     
  7. Baxi M, Di Biase MA, Lyall AE, Cetin-Karayumak S, Seitz J, Ning L, Makris N, Rosene D, Kubicki M, Rathi Y. Quantifying Genetic and Environmental Influence on Gray Matter Microstructure Using Diffusion MRI. Cereb Cortex. 2020 Nov 03; 30(12):6191-6205. PMID: 32676671
     
  8. Rushmore RJ, Bouix S, Kubicki M, Rathi Y, Rosene DL, Yeterian EH, Makris N. MRI-based Parcellation and Morphometry of the Individual Rhesus Monkey Brain: the macaque Harvard-Oxford Atlas (mHOA), a translational system referencing a standardized ontology. Brain Imaging Behav. 2020 Sep 22.View Related Profiles. PMID: 32960419
     
  9. Stonebarger GA, Urbanski HF, Woltjer RL, Vaughan KL, Ingram DK, Schultz PL, Calderazzo SM, Siedeman JA, Mattison JA, Rosene DL, Kohama SG. Amyloidosis increase is not attenuated by long-term calorie restriction or related to neuron density in the prefrontal cortex of extremely aged rhesus macaques. Geroscience. 2020 Dec; 42(6):1733-1749. PMID: 32876855
     
  10. Calderazzo SM, Busch SE, Moore TL, Rosene DL, Medalla M. Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex. J Comp Neurol. 2021 Mar; 529(4):885-904.View Related Profiles. PMID: 32677044
     
Showing 10 of 175 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 164 publications over 39 distinct years, with a maximum of 10 publications in 2020

YearPublications
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202010
20213

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

histology
neural imaging
neural receptors
neuroanatomy
neurobiology
neurophysiology
neuropsychology
neurotransmitters
stereology

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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