Douglas L. Rosene, PhD
Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, University of Rochester




My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys
02/01/2019 - 11/30/2020 (PI)
NIH/National Institute on Aging
1R21AG061678-01

Collaborative Research: Unraveling Cerebral Connectivity with Diffusion MRI, Microscopy and Statistical Physics
08/15/2015 - 07/31/2020 (Co-PI)
PI: H. Eugene Stanley, PhD
National Science Foundation
PHY-1505000

Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
06/01/2016 - 05/31/2019 (PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-05

Effects of Curcumin on Frontal Circuitry in Aging Monkeys using MRI Connectome
05/01/2016 - 04/30/2019 (PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NCCIH
5R21AT008865-02

Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St
09/01/2017 - 07/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
7U01NS076474-03

Histopathology, Neuroimaging, and Mechanism of Myelin Damage in Aging Monkey Brain
06/15/2016 - 04/30/2018 (PI)
NIH/National Institute on Aging
5R01AG043640-05

Translational Development of GGF2 as a Stroke Recovery Therapeutic
08/01/2016 - 08/01/2017 (PI)
Acorda Therapeutics, Inc. NIH NINDS
5U01NS076474-02

Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
09/15/2013 - 05/31/2016 (PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-03

Histopathology, Neuroimaging, and Mechanism of Myelin Damage in Aging Monkey Brain
08/01/2013 - 04/30/2016 (PI)
NIH/National Institute on Aging
5R01AG043640-03

The Human Connectome Project (HCP)
09/01/2013 - 08/31/2015 (PI)
Massachusetts General Hospital NIH NIMH
5U01MH093765-05

Showing 10 of 21 results. Show All Results



Yr Title Project-Sub Proj Pubs
2019 Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the Influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity 1R21NS111174-01
2019 White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys 1R21AG061678-01
2019 Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie Restriction 2R01AG043640-06 14
2017 Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St 7U01NS076474-03
2017 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-05 35
2017 Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey Brain 5R01AG043640-05 14
2016 Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St 5U01NS076474-02
2016 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 4R01AG042512-04 35
2016 Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey Brain 4R01AG043640-04 14
2015 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 3R01AG042512-02S1 35
Showing 10 of 84 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Orczykowski ME, Calderazzo SM, Shobin E, Pessina MA, Oblak AL, Finklestein SP, Kramer BC, Mortazavi F, Rosene DL, Moore TL. Cell based therapy reduces secondary damage and increases extent of microglial activation following cortical injury. Brain Res. 2019 Aug 15; 1717:147-159.View Related Profiles. PMID: 30998931.
     
  2. Alber J, Alladi S, Bae HJ, Barton DA, Beckett LA, Bell JM, Berman SE, Biessels GJ, Black SE, Bos I, Bowman GL, Brai E, Brickman AM, Callahan BL, Corriveau RA, Fossati S, Gottesman RF, Gustafson DR, Hachinski V, Hayden KM, Helman AM, Hughes TM, Isaacs JD, Jefferson AL, Johnson SC, Kapasi A, Kern S, Kwon JC, Kukolja J, Lee A, Lockhart SN, Murray A, Osborn KE, Power MC, Price BR, Rhodius-Meester HFM, Rondeau JA, Rosen AC, Rosene DL, Schneider JA, Scholtzova H, Shaaban CE, Silva NCBS, Snyder HM, Swardfager W, Troen AM, van Veluw SJ, Vemuri P, Wallin A, Wellington C, Wilcock DM, Xie SX, Hainsworth AH. White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities. Alzheimers Dement (N Y). 2019; 5:107-117. PMID: 31011621.
     
  3. Kubicki M, Baxi M, Pasternak O, Tang Y, Karmacharya S, Chunga N, Lyall AE, Rathi Y, Eckbo R, Bouix S, Mortazavi F, Papadimitriou G, Shenton ME, Westin CF, Killiany R, Makris N, Rosene DL. Lifespan Trajectories of White Matter Changes in Rhesus Monkeys. Cereb Cortex. 2019 Apr 01; 29(4):1584-1593.View Related Profiles. PMID: 29701751.
     
  4. Mokler DJ, McGaughy JA, Bass D, Morgane PJ, Rosene DL, Amaral AC, Rushmore RJ, Galler JR. Prenatal Protein Malnutrition Leads to Hemispheric Differences in the Extracellular Concentrations of Norepinephrine, Dopamine and Serotonin in the Medial Prefrontal Cortex of Adult Rats. Front Neurosci. 2019; 13:136.View Related Profiles. PMID: 30890908.
     
  5. Pessina MA, Bowley BGE, Rosene DL, Moore TL. A method for assessing recovery of fine motor function of the hand in a rhesus monkey model of cortical injury: an adaptation of the Fugl-Meyer Scale and Eshkol-Wachman Movement Notation. Somatosens Mot Res. 2019 Mar; 36(1):69-77.View Related Profiles. PMID: 31072219.
     
  6. Koo BB, Calderazzo S, Bowley BGE, Kolli A, Moss MB, Rosene DL, Moore TL. Long-term effects of curcumin in the non-human primate brain. Brain Res Bull. 2018 09; 142:88-95.View Related Profiles. PMID: 29981358.
     
  7. Mortazavi F, Oblak AL, Morrison WZ, Schmahmann JD, Stanley HE, Wedeen VJ, Rosene DL. Geometric Navigation of Axons in a Cerebral Pathway: Comparing dMRI with Tract Tracing and Immunohistochemistry. Cereb Cortex. 2018 04 01; 28(4):1219-1232.View Related Profiles. PMID: 28203748; DOI: 10.1093/cercor/bhx034;.
     
  8. Orczykowski ME, Arndt KR, Palitz LE, Kramer BC, Pessina MA, Oblak AL, Finklestein SP, Mortazavi F, Rosene DL, Moore TL. Cell based therapy enhances activation of ventral premotor cortex to improve recovery following primary motor cortex injury. Exp Neurol. 2018 07; 305:13-25.View Related Profiles. PMID: 29540323.
     
  9. Moore TL, Bowley BGE, Shultz PL, Calderazzo SM, Shobin EJ, Uprety AR, Rosene DL, Moss MB. Oral curcumin supplementation improves fine motor function in the middle-aged rhesus monkey. Somatosens Mot Res. 2018 03; 35(1):1-10.View Related Profiles. PMID: 29447046.
     
  10. Seth N, Simmons HA, Masood F, Graham WA, Rosene DL, Westmoreland SV, Cummings SM, Gwardjan B, Sejdic E, Hoggatt AF, Schalk DR, Abdullah HA, Sledge JB, Nesathurai S. Model of Traumatic Spinal Cord Injury for Evaluating Pharmacologic Treatments in Cynomolgus Macaques (Macaca fasicularis). Comp Med. 2018 02 01; 68(1):63-73. PMID: 29460723.
     
Showing 10 of 158 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 147 publications over 37 distinct years, with a maximum of 9 publications in 2003 and 2005

YearPublications
19801
19811
19822
19831
19841
19853
19861
19872
19884
19891
19902
19935
19943
19953
19963
19975
19983
19997
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20023
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20048
20059
20067
20072
20087
20095
20103
20116
20128
20133
20143
20153
20163
20175
20186
20195
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

histology
neural imaging
neural receptors
neuroanatomy
neurobiology
neurophysiology
neuropsychology
neurotransmitters
stereology

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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