Douglas L. Rosene, PhD
Professor
Boston University Chobanian & Avedisian School of Medicine
Anatomy & Neurobiology

PhD, University of Rochester
AB, Stanford University



My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Unraveling the superficial white matter of the primate brain: Tracer-based histology and dMRI tractography validation
07/01/2022 - 06/30/2027 (Multi-PI)
PI: Douglas L. Rosene, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R01NS125307-02

Optimization and validation of quantitative birefringence microscopy for assessment of myelin pathologies associated with cognitive impairments and motor deficits in young and old aging monkey brain
01/01/2022 - 11/30/2026 (Multi-PI)
PI: Douglas L. Rosene, PhD
NIH/National Institute on Aging
5R01AG075727-03

Age-related cognitive decline and myelin pathology: A comprehensive study of oligodendroglia, microglia and myelin homeostasis in the normal aging monkey
05/15/2019 - 06/30/2024 (PI)
NIH/National Institute on Aging
1RF1AG062831-01

Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie Restriction
02/15/2019 - 06/30/2024 (PI)
NIH/National Institute on Aging
2RF1AG043640-06

Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
08/15/2019 - 04/30/2024 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-09

Neural dynamics underlying integration of sensory, reward and motor effort information in the macaque brain
01/15/2020 - 01/14/2023 (Key Person / Mentor)
PI: Chandramouli Chandrasekaran, PhD
Brain & Behavior Research Foundation


Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity
04/01/2019 - 03/31/2022 (Multi-PI)
PI: Douglas L. Rosene, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R21NS111174-01

White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys
02/01/2019 - 11/30/2021 (PI)
NIH/National Institute on Aging
5R21AG061678-02

Collaborative Research: Unraveling Cerebral Connectivity with Diffusion MRI, Microscopy and Statistical Physics
08/15/2015 - 01/31/2021 (Co-Investigator)
National Science Foundation
PHY-1505000

Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
06/01/2016 - 05/31/2019 (Multi-PI)
PI: Douglas L. Rosene, PhD
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-05

Showing 10 of 28 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2023 Unraveling the Superficial White Matter of the Primate Brain: Tracer-Based Histology and dMRI Tractography Validation 5R01NS125307-02
2023 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-10
2022 Unraveling the superficial white matter of the primate brain: Tracer-based histology and dMRI tractography validation 1R01NS125307-01A1
2021 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-08 40
2020 White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys 5R21AG061678-02
2020 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-07 40
2019 Age-related cognitive decline and myelin pathology: A comprehensive study of oligodendroglia, microglia and myelin homeostasis in the normal aging monkey 1RF1AG062831-01
2019 Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the Influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity 1R21NS111174-01 1
2019 White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys 1R21AG061678-01
2019 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 2R01AG042512-06 40
Showing 10 of 92 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Tsolias A, Zhou Y, Mojica CA, Sakharkar M, Tsolias MZ, Moore TL, Rosene DL, Medalla M. Neuroanatomical Substrates of Circuit-Specific Cholinergic Modulation across the Primate Anterior Cingulate Cortex. J Neurosci. 2024 Jun 12; 44(24).View Related Profiles. PMID: 38719447; PMCID: PMC11170673; DOI: 10.1523/JNEUROSCI.0953-23.2024;
     
  2. Vitantonio AT, Dimovasili C, Mortazavi F, Vaughan KL, Mattison JA, Rosene DL. Long-term calorie restriction reduces oxidative DNA damage to oligodendroglia and promotes homeostatic microglia in the aging monkey brain. Neurobiol Aging. 2024 May 16; 141:1-13.View Related Profiles. PMID: 38788462
     
  3. Cheng S, Chang S, Li Y, Novoseltseva A, Lin S, Wu Y, Zhu J, McKee AC, Rosene DL, Wang H, Bigio IJ, Boas DA, Tian L. Enhanced Multiscale Human Brain Imaging by Semi-supervised Digital Staining and Serial Sectioning Optical Coherence Tomography. Res Sq. 2024 Mar 21.View Related Profiles. PMID: 38562721; PMCID: PMC10984089; DOI: 10.21203/rs.3.rs-4014687/v1;
     
  4. Liu YS, Baxi M, Madan CR, Zhan K, Makris N, Rosene DL, Killiany RJ, Cetin-Karayumak S, Pasternak O, Kubicki M, Cao B. Brain age of rhesus macaques over the lifespan. Neurobiol Aging. 2024 Jul; 139:73-81. PMID: 38643691
     
  5. Amaral DG, Augustinack J, Barbas H, Frosch M, Gabrieli J, Luebke J, Rakic P, Rosene D, Rushmore RJ. The analysis of H.M.'s brain: A brief review of status and plans for future studies and tissue archive. Hippocampus. 2024 Feb; 34(2):52-57.View Related Profiles. PMID: 38189522
     
  6. Vogt BA, Rosene DL. Comparison of monkey and human retrosplenial neurocytology. J Comp Neurol. 2023 Dec; 531(18):2044-2061. PMID: 38062543
     
  7. DeVries SA, Conner B, Dimovasili C, Moore TL, Medalla M, Mortazavi F, Rosene DL. Immune proteins C1q and CD47 may contribute to aberrant microglia-mediated synapse loss in the aging monkey brain that is associated with cognitive impairment. Geroscience. 2024 Apr; 46(2):2503-2519.View Related Profiles. PMID: 37989825; PMCID: PMC10828237; DOI: 10.1007/s11357-023-01014-x;
     
  8. Bautista J, García-Cabezas MÁ, Medalla M, Rosene DL, Zikopoulos B, Barbas H. Pattern of ventral temporal lobe interconnections in rhesus macaques. J Comp Neurol. 2023 Dec; 531(18):1963-1986. PMID: 37919833; PMCID: PMC11142421; DOI: 10.1002/cne.25550;
     
  9. He S, Guan Y, Cheng CH, Moore TL, Luebke JI, Killiany RJ, Rosene DL, Koo BB, Ou Y. Human-to-monkey transfer learning identifies the frontal white matter as a key determinant for predicting monkey brain age. Front Aging Neurosci. 2023; 15:1249415.View Related Profiles. PMID: 38020785; PMCID: PMC10646581; DOI: 10.3389/fnagi.2023.1249415;
     
  10. Zhou Y, Bhatt H, Mojica CA, Xin H, Pessina MA, Rosene DL, Moore TL, Medalla M. Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys. J Neuroinflammation. 2023 Sep 02; 20(1):201.View Related Profiles. PMID: 37660145; PMCID: PMC10475204; DOI: 10.1186/s12974-023-02880-0;
     
Showing 10 of 205 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 194 publications over 42 distinct years, with a maximum of 13 publications in 2021

YearPublications
19801
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19822
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19841
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19861
19872
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19891
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20087
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20175
20186
20199
20209
202113
20227
20239
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In addition to these self-described keywords below, a list of MeSH based concepts is available here.

histology
neural imaging
neural receptors
neuroanatomy
neurobiology
neurophysiology
neuropsychology
neurotransmitters
stereology

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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