Douglas L. Rosene, PhD
Professor
Boston University Chobanian & Avedisian School of Medicine
Dept of Anatomy & Neurobiology

PhD, University of Rochester



My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Unraveling the superficial white matter of the primate brain: Tracer-based histology and dMRI tractography validation
07/01/2022 - 06/30/2027 (Multi-PI)
PI: Douglas L. Rosene, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R01NS125307-01A1

Optimization and validation of quantitative birefringence microscopy for assessment of myelin pathologies associated with cognitive impairments and motor deficits in young and old aging monkey brain
01/01/2022 - 11/30/2026 (Multi-PI)
PI: Douglas L. Rosene, PhD
NIH/National Institute on Aging
1R01AG075727-01

Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
08/15/2019 - 04/30/2024 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-09

Age-related cognitive decline and myelin pathology: A comprehensive study of oligodendroglia, microglia and myelin homeostasis in the normal aging monkey
05/15/2019 - 03/31/2024 (PI)
NIH/National Institute on Aging
1RF1AG062831-01

Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie Restriction
02/15/2019 - 01/31/2024 (PI)
NIH/National Institute on Aging
2RF1AG043640-06

Neural dynamics underlying integration of sensory, reward and motor effort information in the macaque brain
01/15/2020 - 01/14/2023 (Key Person / Mentor)
PI: Chandramouli Chandrasekaran, PhD
Brain & Behavior Research Foundation


Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity
04/01/2019 - 03/31/2022 (Multi-PI)
PI: Douglas L. Rosene, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R21NS111174-01

White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys
02/01/2019 - 11/30/2021 (PI)
NIH/National Institute on Aging
5R21AG061678-02

Collaborative Research: Unraveling Cerebral Connectivity with Diffusion MRI, Microscopy and Statistical Physics
08/15/2015 - 01/31/2021 (Co-Investigator)
National Science Foundation
PHY-1505000

Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
06/01/2016 - 05/31/2019 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-05

Showing 10 of 28 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2022 Unraveling the superficial white matter of the primate brain: Tracer-based histology and dMRI tractography validation 1R01NS125307-01A1
2021 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-08 40
2020 White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys 5R21AG061678-02
2020 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-07 40
2019 Age-related cognitive decline and myelin pathology: A comprehensive study of oligodendroglia, microglia and myelin homeostasis in the normal aging monkey 1RF1AG062831-01
2019 Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the Influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity 1R21NS111174-01 1
2019 White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys 1R21AG061678-01
2019 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 2R01AG042512-06 40
2019 Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie Restriction 2RF1AG043640-06
2017 Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St 7U01NS076474-03
Showing 10 of 90 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Medalla M, Chang W, Ibañez S, Guillamon-Vivancos T, Nittmann M, Kapitonava A, Busch SE, Moore TL, Rosene DL, Luebke JI. Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks. Cereb Cortex. 2022 05 14; 32(10):2170-2196.View Related Profiles. PMID: 34613380; PMCID: PMC9113240; DOI: 10.1093/cercor/bhab347;
     
  2. Nieder C, Rosene DL, Mortazavi F, Oblak AL, Ketten DR. Morphology and unbiased stereology of the lateral superior olive in the short-beaked common dolphin, Delphinus delphis (Cetacea, Delphinidae). J Morphol. 2022 04; 283(4):446-461.View Related Profiles. PMID: 35066941
     
  3. Eldridge SA, Mortazavi F, Rice FL, Ketten DR, Wiley DN, Lyman E, Reidenberg JS, Hanke FD, DeVreese S, Strobel SM, Rosene DL. Specializations of somatosensory innervation in the skin of humpback whales (Megaptera novaeangliae). Anat Rec (Hoboken). 2022 03; 305(3):514-534.View Related Profiles. PMID: 35023618; DOI: 10.1002/ar.24856;
     
  4. Uprety A, Moss MB, Rosene DL, Killiany RJ, Moore TL. Curcumin improves reversal learning in middle-aged rhesus monkeys. Behav Neurosci. 2022 Apr; 136(2):126-138.View Related Profiles. PMID: 34780208
     
  5. Zhang J, Buller BA, Zhang ZG, Zhang Y, Lu M, Rosene DL, Medalla M, Moore TL, Chopp M. Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system. Exp Neurol. 2022 01; 347:113895.View Related Profiles. PMID: 34653510
     
  6. Bottenfield KR, Bowley BGE, Pessina MA, Medalla M, Rosene DL, Moore TL. Sex differences in recovery of motor function in a rhesus monkey model of cortical injury. Biol Sex Differ. 2021 10 09; 12(1):54.View Related Profiles. PMID: 34627376; PMCID: PMC8502310; DOI: 10.1186/s13293-021-00398-9;
     
  7. Church NT, Weissner W, Galler JR, Amaral AC, Rosene DL, McGaughy JA, Rushmore RJ, Larrabee E, Mokler DJ. In vivo microdialysis shows differential effects of prenatal protein malnutrition and stress on norepinephrine, dopamine, and serotonin levels in rat orbital frontal cortex. Behav Neurosci. 2021 Oct; 135(5):629-641. PMID: 34582223; PMCID: PMC8809524; DOI: 10.1037/bne0000479;
     
  8. Farris CW, Killiany RJ, O'Donoghue E, Koo BB, Wainford RD, Moss MB, Rosene DL, Moore TL. The relationship of age and hypertension with cognition and gray matter cerebral blood volume in a rhesus monkey model of human aging. Behav Neurosci. 2021 Oct; 135(5):680-692.View Related Profiles. PMID: 34197136
     
  9. Rushmore RJ, Bouix S, Kubicki M, Rathi Y, Rosene DL, Yeterian EH, Makris N. MRI-based Parcellation and Morphometry of the Individual Rhesus Monkey Brain: the macaque Harvard-Oxford Atlas (mHOA), a translational system referencing a standardized ontology. Brain Imaging Behav. 2021 Jun; 15(3):1589-1621.View Related Profiles. PMID: 32960419; PMCID: PMC8608281; DOI: 10.1007/s11682-020-00357-9;
     
  10. Clark IC, Gutiérrez-Vázquez C, Wheeler MA, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao CC, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, Manganeli Polonio C, Shultis MW, Salem Y, Tjon EC, Fonseca-Castro PH, Borucki DM, Alves de Lima K, Plasencia A, Abate AR, Rosene DL, Hodgetts KJ, Prinz M, Antel JP, Prat A, Quintana FJ. Barcoded viral tracing of single-cell interactions in central nervous system inflammation. Science. 2021 04 23; 372(6540). PMID: 33888612; PMCID: PMC8157482; DOI: 10.1126/science.abf1230;
     
Showing 10 of 187 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 176 publications over 40 distinct years, with a maximum of 13 publications in 2021

YearPublications
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In addition to these self-described keywords below, a list of MeSH based concepts is available here.

histology
neural imaging
neural receptors
neuroanatomy
neurobiology
neurophysiology
neuropsychology
neurotransmitters
stereology

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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