Douglas L. Rosene, PhD
Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, University of Rochester




My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
08/15/2019 - 04/30/2024 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
2R01AG042512-06

Age-related cognitive decline and myelin pathology: A comprehensive study of oligodendroglia, microglia and myelin homeostasis in the normal aging monkey
05/15/2019 - 03/31/2024 (PI)
NIH/National Institute on Aging
1RF1AG062831-01

Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie Restriction
02/15/2019 - 01/31/2024 (PI)
NIH/National Institute on Aging
2RF1AG043640-06

Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity
04/01/2019 - 03/31/2021 (Multi-PI)
PI: Douglas L. Rosene, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R21NS111174-01

White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys
02/01/2019 - 11/30/2020 (PI)
NIH/National Institute on Aging
5R21AG061678-02

Collaborative Research: Unraveling Cerebral Connectivity with Diffusion MRI, Microscopy and Statistical Physics
08/15/2015 - 07/31/2020 (Co-PI)
PI: H. Eugene Stanley, PhD
National Science Foundation
PHY-1505000

Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
06/01/2016 - 05/31/2019 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-05

Effects of Curcumin on Frontal Circuitry in Aging Monkeys using MRI Connectome
05/01/2016 - 04/30/2019 (Subcontract PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NCCIH
5R21AT008865-02

Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St
09/01/2017 - 07/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
7U01NS076474-03

Histopathology, Neuroimaging, and Mechanism of Myelin Damage in Aging Monkey Brain
06/15/2016 - 04/30/2018 (PI)
NIH/National Institute on Aging
5R01AG043640-05

Showing 10 of 25 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2020 White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys 5R21AG061678-02
2020 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-07 40
2019 Age-related cognitive decline and myelin pathology: A comprehensive study of oligodendroglia, microglia and myelin homeostasis in the normal aging monkey 1RF1AG062831-01
2019 Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the Influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity 1R21NS111174-01 1
2019 White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys 1R21AG061678-01
2019 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 2R01AG042512-06 40
2019 Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie Restriction 2RF1AG043640-06
2017 Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St 7U01NS076474-03
2017 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-05 40
2017 Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey Brain 5R01AG043640-05 14
Showing 10 of 88 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Baxi M, Di Biase MA, Lyall AE, Cetin-Karayumak S, Seitz J, Ning L, Makris N, Rosene D, Kubicki M, Rathi Y. Quantifying Genetic and Environmental Influence on Gray Matter Microstructure Using Diffusion MRI. Cereb Cortex. 2020 Jul 17. PMID: 32676671
     
  2. Calderazzo SM, Busch SE, Moore TL, Rosene DL, Medalla M. Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex. J Comp Neurol. 2020 Jul 17.View Related Profiles. PMID: 32677044
     
  3. Brasó-Vives M, Povolotskaya IS, Hartasánchez DA, Farré X, Fernandez-Callejo M, Raveendran M, Harris RA, Rosene DL, Lorente-Galdos B, Navarro A, Marques-Bonet T, Rogers J, Juan D. Copy number variants and fixed duplications among 198 rhesus macaques (Macaca mulatta). PLoS Genet. 2020 05; 16(5):e1008742. PMID: 32392208
     
  4. Medalla M, Chang W, Calderazzo SM, Go V, Tsolias A, Goodliffe JW, Pathak D, De Alba D, Pessina M, Rosene DL, Buller B, Moore TL. Treatment with Mesenchymal-Derived Extracellular Vesicles Reduces Injury-Related Pathology in Pyramidal Neurons of Monkey Perilesional Ventral Premotor Cortex. J Neurosci. 2020 Apr 22; 40(17):3385-3407.View Related Profiles. PMID: 32241837
     
  5. Carmichael CY, Kuwabara JT, Pascale CL, Moreira JD, Mahne SE, Kapusta DR, Rosene DL, Williams JS, Cunningham JT, Wainford RD. Hypothalamic Paraventricular Nucleus Gai2 (Guanine Nucleotide-Binding Protein Alpha Inhibiting Activity Polypeptide 2) Protein-Mediated Neural Control of the Kidney and the Salt Sensitivity of Blood Pressure. Hypertension. 2020 Apr; 75(4):1002-1011.View Related Profiles. PMID: 32148128
     
  6. Ruan QT, Yazdani N, Blum BC, Beierle JA, Lin W, Coelho MA, Fultz EK, Healy AF, Shahin JR, Kandola AK, Luttik KP, Zheng K, Smith NJ, Cheung J, Mortazavi F, Apicco DJ, Ragu Varman D, Ramamoorthy S, Ash PEA, Rosene DL, Emili A, Wolozin B, Szumlinski KK, Bryant CD. A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins. J Neurosci. 2020 01 02; 40(1):107-130.View Related Profiles. PMID: 31704785
     
  7. Go V, Bowley BGE, Pessina MA, Zhang ZG, Chopp M, Finklestein SP, Rosene DL, Medalla M, Buller B, Moore TL. Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys. Geroscience. 2020 02; 42(1):1-17.View Related Profiles. PMID: 31691891
     
  8. Masood F, Abdullah HA, Seth N, Simmons H, Brunner K, Sejdic E, Schalk DR, Graham WA, Hoggatt AF, Rosene DL, Sledge JB, Nesathurai S. Neurophysiological Characterization of a Non-Human Primate Model of Traumatic Spinal Cord Injury Utilizing Fine-Wire EMG Electrodes. Sensors (Basel). 2019 Jul 27; 19(15). PMID: 31357572
     
  9. Orczykowski ME, Calderazzo SM, Shobin E, Pessina MA, Oblak AL, Finklestein SP, Kramer BC, Mortazavi F, Rosene DL, Moore TL. Cell based therapy reduces secondary damage and increases extent of microglial activation following cortical injury. Brain Res. 2019 08 15; 1717:147-159.View Related Profiles. PMID: 30998931
     
  10. Alber J, Alladi S, Bae HJ, Barton DA, Beckett LA, Bell JM, Berman SE, Biessels GJ, Black SE, Bos I, Bowman GL, Brai E, Brickman AM, Callahan BL, Corriveau RA, Fossati S, Gottesman RF, Gustafson DR, Hachinski V, Hayden KM, Helman AM, Hughes TM, Isaacs JD, Jefferson AL, Johnson SC, Kapasi A, Kern S, Kwon JC, Kukolja J, Lee A, Lockhart SN, Murray A, Osborn KE, Power MC, Price BR, Rhodius-Meester HFM, Rondeau JA, Rosen AC, Rosene DL, Schneider JA, Scholtzova H, Shaaban CE, Silva NCBS, Snyder HM, Swardfager W, Troen AM, van Veluw SJ, Vemuri P, Wallin A, Wellington C, Wilcock DM, Xie SX, Hainsworth AH. White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities. Alzheimers Dement (N Y). 2019; 5:107-117. PMID: 31011621
     
Showing 10 of 167 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 156 publications over 38 distinct years, with a maximum of 9 publications in 2003 and 2005 and 2019

YearPublications
19801
19811
19822
19831
19841
19853
19861
19872
19884
19891
19902
19935
19943
19953
19963
19975
19983
19997
20004
20023
20039
20048
20059
20067
20072
20087
20095
20103
20116
20128
20133
20143
20153
20163
20175
20186
20199
20205

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

histology
neural imaging
neural receptors
neuroanatomy
neurobiology
neurophysiology
neuropsychology
neurotransmitters
stereology

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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