Douglas L. Rosene, PhD
Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, University of Rochester




My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
08/15/2019 - 04/30/2024 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-07

Age-related cognitive decline and myelin pathology: A comprehensive study of oligodendroglia, microglia and myelin homeostasis in the normal aging monkey
05/15/2019 - 03/31/2024 (PI)
NIH/National Institute on Aging
1RF1AG062831-01

Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie Restriction
02/15/2019 - 01/31/2024 (PI)
NIH/National Institute on Aging
2RF1AG043640-06

Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity
04/01/2019 - 03/31/2022 (Multi-PI)
PI: Douglas L. Rosene, PhD
NIH/National Institute of Neurological Disorders & Stroke
1R21NS111174-01

White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys
02/01/2019 - 11/30/2021 (PI)
NIH/National Institute on Aging
5R21AG061678-02

Collaborative Research: Unraveling Cerebral Connectivity with Diffusion MRI, Microscopy and Statistical Physics
08/15/2015 - 01/31/2021 (Co-Investigator)
National Science Foundation
PHY-1505000

Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
06/01/2016 - 05/31/2019 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-05

Effects of Curcumin on Frontal Circuitry in Aging Monkeys using MRI Connectome
05/01/2016 - 04/30/2019 (Subcontract PI)
General Hospital Corp d/b/a Massachusetts General Hospital NIH NCCIH
5R21AT008865-02

Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St
09/01/2017 - 07/31/2018 (PI)
NIH/National Institute of Neurological Disorders & Stroke
7U01NS076474-03

Histopathology, Neuroimaging, and Mechanism of Myelin Damage in Aging Monkey Brain
06/15/2016 - 04/30/2018 (PI)
NIH/National Institute on Aging
5R01AG043640-05

Showing 10 of 25 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2021 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-08 40
2020 White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys 5R21AG061678-02
2020 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-07 40
2019 Age-related cognitive decline and myelin pathology: A comprehensive study of oligodendroglia, microglia and myelin homeostasis in the normal aging monkey 1RF1AG062831-01
2019 Recovery of Motor Function Impaired by Cortical Injury: An Exploratory Comparison of the Influences of Four Different Post-injury Treatments on Processes Affecting Neuroplasticity 1R21NS111174-01 1
2019 White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys 1R21AG061678-01
2019 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 2R01AG042512-06 40
2019 Mechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie Restriction 2RF1AG043640-06
2017 Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St 7U01NS076474-03
2017 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-05 40
Showing 10 of 89 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Farris CW, Killiany RJ, O'Donoghue E, Koo BB, Wainford RD, Moss MB, Rosene DL, Moore TL. The relationship of age and hypertension with cognition and gray matter cerebral blood volume in a rhesus monkey model of human aging. Behav Neurosci. 2021 Jul 01.View Related Profiles. PMID: 34197136
     
  2. Rushmore RJ, Bouix S, Kubicki M, Rathi Y, Rosene DL, Yeterian EH, Makris N. MRI-based Parcellation and Morphometry of the Individual Rhesus Monkey Brain: the macaque Harvard-Oxford Atlas (mHOA), a translational system referencing a standardized ontology. Brain Imaging Behav. 2021 Jun; 15(3):1589-1621.View Related Profiles. PMID: 32960419
     
  3. Clark IC, Gutiérrez-Vázquez C, Wheeler MA, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao CC, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, Manganeli Polonio C, Shultis MW, Salem Y, Tjon EC, Fonseca-Castro PH, Borucki DM, Alves de Lima K, Plasencia A, Abate AR, Rosene DL, Hodgetts KJ, Prinz M, Antel JP, Prat A, Quintana FJ. Barcoded viral tracing of single-cell interactions in central nervous system inflammation. Science. 2021 04 23; 372(6540). PMID: 33888612; PMCID: PMC8157482; DOI: 10.1126/science.abf1230;
     
  4. Tsintou M, Dalamagkas K, Moore TL, Rathi Y, Kubicki M, Rosene DL, Makris N. The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke: a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches. Neural Regen Res. 2021 Apr; 16(4):605-613.View Related Profiles. PMID: 33063708; PMCID: PMC8067932; DOI: 10.4103/1673-5374.295269;
     
  5. Blanke N, Go V, Rosene DL, Bigio IJ. Quantitative birefringence microscopy for imaging the structural integrity of CNS myelin following circumscribed cortical injury in the rhesus monkey. Neurophotonics. 2021 Jan; 8(1):015010.View Related Profiles. PMID: 33763502; PMCID: PMC7984970; DOI: 10.1117/1.NPh.8.1.015010;
     
  6. Buldyrev SV, Meng X, Reese TG, Mortazavi F, Rosene DL, Stanley HE, Wedeen VJ. Diffusion interactions between crossing fibers of the brain. Magn Reson Med. 2021 07; 86(1):429-441.View Related Profiles. PMID: 33619754
     
  7. Batterman KV, Cabrera PE, Moore TL, Rosene DL. T Cells Actively Infiltrate the White Matter of the Aging Monkey Brain in Relation to Increased Microglial Reactivity and Cognitive Decline. Front Immunol. 2021; 12:607691.View Related Profiles. PMID: 33664743; PMCID: PMC7920950; DOI: 10.3389/fimmu.2021.607691;
     
  8. Sanmarco LM, Wheeler MA, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ. Gut-licensed IFN?+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes. Nature. 2021 Feb; 590(7846):473-479. PMID: 33408417; PMCID: PMC8039910; DOI: 10.1038/s41586-020-03116-4;
     
  9. Rushmore RJ, McGaughy JA, Amaral AC, Mokler DJ, Morgane PJ, Galler JR, Rosene DL. The neural basis of attentional alterations in prenatally protein malnourished rats. Cereb Cortex. 2021 01 01; 31(1):497-512.View Related Profiles. PMID: 33099611; PMCID: PMC7947171; DOI: 10.1093/cercor/bhaa239;
     
  10. Warren WC, Harris RA, Haukness M, Fiddes IT, Murali SC, Fernandes J, Dishuck PC, Storer JM, Raveendran M, Hillier LW, Porubsky D, Mao Y, Gordon D, Vollger MR, Lewis AP, Munson KM, DeVogelaere E, Armstrong J, Diekhans M, Walker JA, Tomlinson C, Graves-Lindsay TA, Kremitzki M, Salama SR, Audano PA, Escalona M, Maurer NW, Antonacci F, Mercuri L, Maggiolini FAM, Catacchio CR, Underwood JG, O'Connor DH, Sanders AD, Korbel JO, Ferguson B, Kubisch HM, Picker L, Kalin NH, Rosene D, Levine J, Abbott DH, Gray SB, Sanchez MM, Kovacs-Balint ZA, Kemnitz JW, Thomasy SM, Roberts JA, Kinnally EL, Capitanio JP, Skene JHP, Platt M, Cole SA, Green RE, Ventura M, Wiseman RW, Paten B, Batzer MA, Rogers J, Eichler EE. Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility. Science. 2020 12 18; 370(6523). PMID: 33335035; PMCID: PMC7818670; DOI: 10.1126/science.abc6617;
     
Showing 10 of 180 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 169 publications over 39 distinct years, with a maximum of 9 publications in 2003 and 2005 and 2019 and 2020 and 2021

YearPublications
19801
19811
19822
19831
19841
19853
19861
19872
19884
19891
19902
19935
19943
19953
19963
19975
19983
19997
20004
20023
20039
20048
20059
20067
20072
20087
20095
20103
20116
20128
20133
20143
20153
20163
20175
20186
20199
20209
20219

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

histology
neural imaging
neural receptors
neuroanatomy
neurobiology
neurophysiology
neuropsychology
neurotransmitters
stereology

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Google Map


Rosene's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department