Keywords
Last Name

Richard Wainford, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics
Address700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Phone(617) 414-2648
ORCID ORCID Icon0000-0003-2830-5618
Other Positions
TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionCardiovascular Medicine

 Awards and Honors

Start-EndDescription
2014Howard Hughes Medical Institute (HHMI): Summer Research Program Award
2014The American Physiology Society: Arthur C. Guyton Award for Excellence in Integrative Physiology
2013American Heart Association Council for High Blood Pressure: Research Harry Goldblatt New Investigator
2013Endocrine Society: Early Investigator Award
2013The American Physiological Society: Shih-Chun Wang Young Investigator Award
2013The American Physiological Society Central Nervous System: New Investigator Award
2012International Society of Hypertension: New Investigator of the Month (December)
2012The American Physiological Society: Dean Franklin Young Investigator Award
2011The American Physiological Society: Research Career Enhancement Award
 Research Expertise & Professional Interests
Background:
Dr Wainford obtained a Bachelors in Zoology from the University of Wales, Cardiff in 1999. Dr Wainford undertook his Graduate training in the Laboratory of Molecular Pharmacology and Toxicology in the Department of Medicine and Therapeutics at the University of Aberdeen School of Medicine under the guidance of Professor Hawksworth, earning a PhD in Molecular Pharmacology in 2004. Dr. Wainford then completed a 2-year post-doctoral fellowship in the Department of Pharmacology at the Louisiana State University Health Sciences Center in New Orleans in Cardiovascular & Renal Pharmacology under the mentorship of Dr. Kapusta. Dr. Wainford then became an Instructor of Pharmacology in 2008, remaining in the laboratory of Dr. Kapusta until his promotion to the rank of Assistant Professor in 2010. Dr. Wainford joined the Department of Pharmacology & Experimental Therapeutics at the Boston University School of Medicine and the Whitaker Cardiovascular Institute in 2011 as an Assistant Professor.

Research Summary:
Dr. Wainford is the director of the Laboratory of Cardio-Renal Research. Dr. Wainford’s research interests focus on the central neural control of fluid and electrolyte homeostasis and blood pressure regulation. Dr. Wainford’s laboratory utilizes an integrated physiological, pharmacological, molecular, and gene-targeting approach to investigate the anti-hypertensive role(s) of central G-alpha-subunit proteins in the endogenous GPCR-activated pathways that regulate central sympatheticoutflow, fluid and electrolyte homeostasis, and systemic blood pressure regulation in salt-resistant and salt-sensitive animal models.The major goal of Dr. Wainford’s research is identifying the underlying pathophysiology of and potential treatments for hypertension. Current studies concern the role of central G-alpha subunit protein gated pathways in mediating the neural control of kidney function and systemic arterial blood pressure.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Frame AA, Carmichael CY, Wainford RD. Renal Afferents. Curr Hypertens Rep. 2016 Sep; 18(9):69. PMID: 27595156.
    View in: PubMed
  2. Wainford R, Walsh K. OS 29-04 SYMPATHETIC NERVOUS SYSTEM REGULATION OF THE RENAL NCC AND BLOOD PRESSURE DURING HIGH DIETARY SALT INTAKE. J Hypertens. 2016 Sep; 34 Suppl 1:e253-4. PMID: 27643082.
    View in: PubMed
  3. Wainford R. ED 09-1 RENAL SODIUM HANDLING AND SALT SENSITIVITY. J Hypertens. 2016 Sep; 34 Suppl 1:e537. PMID: 27643273.
    View in: PubMed
  4. Wainford R, Carmichael C, Walsh K. OS 11-01 Afferent renal nerve modulation of sodium homeostasis and blood pressure: A sodium sensitive PVN Gai2 protein dependent mechanism countering the development of salt-sensitive hypertension? J Hypertens. 2016 Sep; 34 Suppl 1:e74. PMID: 27643365.
    View in: PubMed
  5. Wainford R, Carmichael C, Walsh K. OS 11-01 Afferent renal nerve modulation of sodium homeostasis and blood pressure: A sodium sensitive PVN Gai2 protein dependent mechanism countering the development of salt-sensitive hypertension? J Hypertens. 2016 Sep; 34 Suppl 1 - ISH 2016 Abstract Book:e74. PMID: 27753968.
    View in: PubMed
  6. Wainford R, Walsh K. OS 29-04 SYMPATHETIC NERVOUS SYSTEM REGULATION OF THE RENAL NCC AND BLOOD PRESSURE DURING HIGH DIETARY SALT INTAKE. J Hypertens. 2016 Sep; 34 Suppl 1 - ISH 2016 Abstract Book:e253-e254. PMID: 27754152.
    View in: PubMed
  7. Wainford R. ED 09-1 RENAL SODIUM HANDLING AND SALT SENSITIVITY. J Hypertens. 2016 Sep; 34 Suppl 1 - ISH 2016 Abstract Book:e537. PMID: 27754276.
    View in: PubMed
  8. Walsh KR, Kuwabara JT, Shim JW, Wainford RD. Norepinephrine-evoked salt-sensitive hypertension requires impaired renal sodium chloride cotransporter activity in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 15; 310(2):R115-24. PMID: 26608659.
    View in: PubMed
  9. Carmichael CY, Carmichael AC, Kuwabara JT, Cunningham JT, Wainford RD. Impaired sodium-evoked paraventricular nucleus neuronal activation and blood pressure regulation in conscious Sprague-Dawley rats lacking central Gai2 proteins. Acta Physiol (Oxf). 2016 Mar; 216(3):314-29. PMID: 26412230.
    View in: PubMed
  10. Brouwers S, Smolders I, Wainford RD, Dupont AG. Correction: Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats. Clin Sci (Lond). 2015 Oct; 129(7):673. PMID: 26186745.
    View in: PubMed
  11. Carmichael CY, Wainford RD. Brain Gai 2 -subunit proteins and the prevention of salt sensitive hypertension. Front Physiol. 2015; 6:233. PMID: 26347659.
    View in: PubMed
  12. Brouwers S, Smolders I, Wainford RD, Dupont AG. Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats. Clin Sci (Lond). 2015 Jul; 129(1):81-92. PMID: 25655919.
    View in: PubMed
  13. Brouwers S, Wainford RD, Smolders I, Dupont AG. 8D.09: NIGHTTIME HYPOTENSIVE EFFECTS OF CENTRAL ANGIOTENSIN II TYPE 2 RECEPTOR STIMULATION THROUGH IMPROVED SPONTANEOUS BAROREFLEX SENSITIVITY: MORE IN SHR THAN IN WKY. J Hypertens. 2015 Jun; 33 Suppl 1:e116. PMID: 26102696.
    View in: PubMed
  14. Carmichael CY, Wainford RD. Hypothalamic signaling mechanisms in hypertension. Curr Hypertens Rep. 2015 May; 17(5):39. PMID: 25860531.
    View in: PubMed
  15. Carmichael CY, Wainford RD. Impact of global versus renal-specific sympathoinhibition in aldosterone-induced hypertension: implications for medical device-based treatment of resistant hypertension. Hypertension. 2015 Jun; 65(6):1160-2. PMID: 25895585.
    View in: PubMed
  16. Veerabhadrappa P, Burger D, Brouwers S, Christofidou P, Bikai RE, Hannah-Shmouni F, Kruger R, Marques FZ, Rehman Mian MO, Montezano AC, Romero CA, Peña-Silva RA, Wainford RD, Charchar FJ, Schutte AE, Tomaszewski M. Across the globe in 4 months: two International Society of Hypertension new investigator symposia in 2014. J Hypertens. 2015 Apr; 33(4):891-3. PMID: 25668359.
    View in: PubMed
  17. Foss JD, Wainford RD, Engeland WC, Fink GD, Osborn JW. A novel method of selective ablation of afferent renal nerves by periaxonal application of capsaicin. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 15; 308(2):R112-22. PMID: 25411365.
    View in: PubMed
  18. Wainford RD, Carmichael CY, Pascale CL, Kuwabara JT. Gai2-protein-mediated signal transduction: central nervous system molecular mechanism countering the development of sodium-dependent hypertension. Hypertension. 2015 Jan; 65(1):178-86. PMID: 25312437.
    View in: PubMed
  19. Wainford RD. Presympathetic neuron dysfunction--time to reconsider increased intrinsic activity as the cause of neurogenic hypertension. Exp Physiol. 2014 Jul; 99(7):935-6. PMID: 24987020.
    View in: PubMed
  20. Wainford RD. Angiotensin AT2 receptors and the baroreflex control of renal sympathetic nerve activity. Acta Physiol (Oxf). 2014 Apr; 210(4):714-6. PMID: 24447624.
    View in: PubMed
  21. Wainford RD, Pascale CL, Kuwabara JT. Brain Gai2-subunit protein-gated pathways are required to mediate the centrally evoked sympathoinhibitory mechanisms activated to maintain sodium homeostasis. J Hypertens. 2013 Apr; 31(4):747-57. PMID: 23391983.
    View in: PubMed
  22. Kapusta DR, Pascale CL, Kuwabara JT, Wainford RD. Central nervous system Gai2-subunit proteins maintain salt resistance via a renal nerve-dependent sympathoinhibitory pathway. Hypertension. 2013 Feb; 61(2):368-75. PMID: 23213191.
    View in: PubMed
  23. Wainford RD, Kapusta DR. Functional selectivity of central Ga-subunit proteins in mediating the cardiovascular and renal excretory responses evoked by central a(2) -adrenoceptor activation in vivo. Br J Pharmacol. 2012 May; 166(1):210-20. PMID: 21895632.
    View in: PubMed
  24. Kapusta DR, Pascale CL, Wainford RD. Brain heterotrimeric Gai2-subunit protein-gated pathways mediate central sympathoinhibition to maintain fluid and electrolyte homeostasis during stress. FASEB J. 2012 Jul; 26(7):2776-87. PMID: 22459149.
    View in: PubMed
  25. Yoshida T, Semprun-Prieto L, Wainford RD, Sukhanov S, Kapusta DR, Delafontaine P. Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus. Endocrinology. 2012 Mar; 153(3):1411-20. PMID: 22234465.
    View in: PubMed
  26. Wainford RD, Kapusta DR. Hypothalamic paraventricular nucleus G alpha q subunit protein pathways mediate vasopressin dysregulation and fluid retention in salt-sensitive rats. Endocrinology. 2010 Nov; 151(11):5403-14. PMID: 20861238.
    View in: PubMed
  27. Wainford RD, Weaver RJ, Hawksworth GM. The immediate early genes, c-fos, c-jun and AP-1, are early markers of platinum analogue toxicity in human proximal tubular cell primary cultures. Toxicol In Vitro. 2009 Aug; 23(5):780-8. PMID: 19383537.
    View in: PubMed
  28. Wainford RD, Kapusta DR. Chronic high-NaCl intake prolongs the cardiorenal responses to central N/OFQ and produces regional changes in the endogenous brain NOP receptor system. Am J Physiol Regul Integr Comp Physiol. 2009 Feb; 296(2):R280-8. PMID: 18987291.
    View in: PubMed
  29. Wainford RD, Kurtz K, Kapusta DR. Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol. 2008 Aug; 295(2):R535-42. PMID: 18525017.
    View in: PubMed
  30. Wainford RD, Weaver RJ, Stewart KN, Brown P, Hawksworth GM. Cisplatin nephrotoxicity is mediated by gamma glutamyltranspeptidase, not via a C-S lyase governed biotransformation pathway. Toxicology. 2008 Jul 30; 249(2-3):184-93. PMID: 18583013.
    View in: PubMed
  31. Rizzi A, Spagnolo B, Wainford RD, Fischetti C, Guerrini R, Marzola G, Baldisserotto A, Salvadori S, Regoli D, Kapusta DR, Calo G. In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor. Peptides. 2007 Jun; 28(6):1240-51. PMID: 17532097.
    View in: PubMed
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