Richard Wainford, PhD
Associate Professor
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

PhD, University of Aberdeen



Background:
Dr Wainford obtained a Bachelors in Zoology from the University of Wales, Cardiff in 1999. Dr Wainford undertook his Graduate training in the Laboratory of Molecular Pharmacology and Toxicology in the Department of Medicine and Therapeutics at the University of Aberdeen School of Medicine under the guidance of Professor Hawksworth, earning a PhD in Molecular Pharmacology in 2004. Dr. Wainford then completed a 2-year post-doctoral fellowship in the Department of Pharmacology at the Louisiana State University Health Sciences Center in New Orleans in Cardiovascular & Renal Pharmacology under the mentorship of Dr. Kapusta. Dr. Wainford then became an Instructor of Pharmacology in 2008, remaining in the laboratory of Dr. Kapusta until his promotion to the rank of Assistant Professor in 2010. Dr. Wainford joined the Department of Pharmacology & Experimental Therapeutics at the Boston University School of Medicine and the Whitaker Cardiovascular Institute in 2011 as an Assistant Professor.

Research Summary:
Dr. Wainford is the director of the Laboratory of Cardio-Renal Research. Dr. Wainford’s research interests focus on the central neural control of fluid and electrolyte homeostasis and blood pressure regulation. Dr. Wainford’s laboratory utilizes an integrated physiological, pharmacological, molecular, and gene-targeting approach to investigate the anti-hypertensive role(s) of central G-alpha-subunit proteins in the endogenous GPCR-activated pathways that regulate central sympatheticoutflow, fluid and electrolyte homeostasis, and systemic blood pressure regulation in salt-resistant and salt-sensitive animal models.The major goal of Dr. Wainford’s research is identifying the underlying pathophysiology of and potential treatments for hypertension. Current studies concern the role of central G-alpha subunit protein gated pathways in mediating the neural control of kidney function and systemic arterial blood pressure.

Associate Professor
Boston University School of Medicine
Medicine
Cardiovascular Medicine Section


2014 The American Physiology Society: Arthur C. Guyton Award for Excellence in Integrative Physiology
2014 Howard Hughes Medical Institute (HHMI): Summer Research Program Award
2013 American Heart Association Council for High Blood Pressure: Research Harry Goldblatt New Investigator
2013 The American Physiological Society Central Nervous System: New Investigator Award
2013 Endocrine Society: Early Investigator Award
2013 The American Physiological Society: Shih-Chun Wang Young Investigator Award
2012 International Society of Hypertension: New Investigator of the Month (December)
2012 The American Physiological Society: Dean Franklin Young Investigator Award
2011 The American Physiological Society: Research Career Enhancement Award


Brain G-alpha subunit protein mediated neural control of blood pressure
10/01/2011 - 07/31/2018 (PI)
NIH/National Heart, Lung, and Blood Inst
5R01HL107330-05

Neural Control of the Kidney and Blood Pressure Regulation
07/01/2017 - 06/30/2018 (PI)
American Heart Association

Brain G-Alpha Subunit Protein Mediated Neural Control of Blood Pressure
06/01/2016 - 05/31/2018 (PI)
NIH/National Heart, Lung, and Blood Inst
5K02HL112718-05

Mentoring in neural and Cardiorenal Pathophysiology
07/01/2016 - 06/30/2017 (PI)
American Heart Association


Brain G-Alpha Subunit Protein Mediated Neural Control of Blood Pressure
08/20/2013 - 05/31/2016 (PI)
NIH/National Heart, Lung, and Blood Inst
5K02HL112718-03



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Frame AA, Wainford RD. Renal sodium handling and sodium sensitivity. Kidney Res Clin Pract. 2017 Jun; 36(2):117-131.View Related Profiles. PMID: 28680820.
  2. Frame AA, Carmichael CY, Wainford RD. Renal Afferents. Curr Hypertens Rep. 2016 Sep; 18(9):69.View Related Profiles. PMID: 27595156; PMCID: PMC5011151; DOI: 10.1007/s11906-016-0676-z;.
  3. Walsh KR, Kuwabara JT, Shim JW, Wainford RD. Norepinephrine-evoked salt-sensitive hypertension requires impaired renal sodium chloride cotransporter activity in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 15; 310(2):R115-24.View Related Profiles. PMID: 26608659; PMCID: PMC4796647; DOI: 10.1152/ajpregu.00514.2014;.
  4. Carmichael CY, Carmichael AC, Kuwabara JT, Cunningham JT, Wainford RD. Impaired sodium-evoked paraventricular nucleus neuronal activation and blood pressure regulation in conscious Sprague-Dawley rats lacking central Gai2 proteins. Acta Physiol (Oxf). 2016 Mar; 216(3):314-29. PMID: 26412230; PMCID: PMC4764872; DOI: 10.1111/apha.12610;.
  5. Brouwers S, Smolders I, Wainford RD, Dupont AG. Correction: Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats. Clin Sci (Lond). 2015 Oct; 129(7):673. PMID: 26186745; DOI: 10.1042/CS1290673b;.
  6. Carmichael CY, Wainford RD. Brain Gai 2 -subunit proteins and the prevention of salt sensitive hypertension. Front Physiol. 2015; 6:233.View Related Profiles. PMID: 26347659; DOI: 10.3389/fphys.2015.00233;.
  7. Brouwers S, Smolders I, Wainford RD, Dupont AG. Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats. Clin Sci (Lond). 2015 Jul; 129(1):81-92. PMID: 25655919; PMCID: PMC4430196; DOI: 10.1042/CS20140776;.
  8. Brouwers S, Wainford RD, Smolders I, Dupont AG. 8D.09: NIGHTTIME HYPOTENSIVE EFFECTS OF CENTRAL ANGIOTENSIN II TYPE 2 RECEPTOR STIMULATION THROUGH IMPROVED SPONTANEOUS BAROREFLEX SENSITIVITY: MORE IN SHR THAN IN WKY. J Hypertens. 2015 Jun; 33 Suppl 1:e116. PMID: 26102696; DOI: 10.1097/01.hjh.0000467663.61532.18;.
  9. Carmichael CY, Wainford RD. Hypothalamic signaling mechanisms in hypertension. Curr Hypertens Rep. 2015 May; 17(5):39.View Related Profiles. PMID: 25860531; PMCID: PMC4392165; DOI: 10.1007/s11906-015-0550-4;.
  10. Carmichael CY, Wainford RD. Impact of global versus renal-specific sympathoinhibition in aldosterone-induced hypertension: implications for medical device-based treatment of resistant hypertension. Hypertension. 2015 Jun; 65(6):1160-2.View Related Profiles. PMID: 25895585; PMCID: PMC4433421; DOI: 10.1161/HYPERTENSIONAHA.115.05228;.
Showing 10 of 26 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 26 publications over 10 distinct years, with a maximum of 9 publications in 2015

YearPublications
20071
20083
20091
20101
20124
20131
20144
20159
20161
20171

Available to Mentor as: (Review Mentor Role Definitions):
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Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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