Richard Wainford, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

PhD, University of Aberdeen
BSc, University of Wales



Background:
Dr Wainford obtained a Bachelors in Zoology from the University of Wales, Cardiff in 1999. Dr Wainford undertook his Graduate training in the Laboratory of Molecular Pharmacology and Toxicology in the Department of Medicine and Therapeutics at the University of Aberdeen School of Medicine under the guidance of Professor Hawksworth, earning a PhD in Molecular Pharmacology in 2004. Dr. Wainford then completed a 2-year post-doctoral fellowship in the Department of Pharmacology at the Louisiana State University Health Sciences Center in New Orleans in Cardiovascular & Renal Pharmacology under the mentorship of Dr. Kapusta. Dr. Wainford then became an Instructor of Pharmacology in 2008, remaining in the laboratory of Dr. Kapusta until his promotion to the rank of Assistant Professor in 2010. Dr. Wainford joined the Department of Pharmacology & Experimental Therapeutics at the Chobanian and Avedisian School of Medicine and the Whitaker Cardiovascular Institute in 2011 as an Assistant Professor.

Research Summary:
Dr. Wainford is the director of the Laboratory of Cardio-Renal Research. Dr. Wainford’s research interests focus on the central neural control of fluid and electrolyte homeostasis and blood pressure regulation. Dr. Wainford’s laboratory utilizes an integrated physiological, pharmacological, molecular, and gene-targeting approach to investigate the anti-hypertensive role(s) of central G-alpha-subunit proteins in the endogenous GPCR-activated pathways that regulate central sympatheticoutflow, fluid and electrolyte homeostasis, and systemic blood pressure regulation in salt-resistant and salt-sensitive animal models.The major goal of Dr. Wainford’s research is identifying the underlying pathophysiology of and potential treatments for hypertension. Current studies concern the role of central G-alpha subunit protein gated pathways in mediating the neural control of kidney function and systemic arterial blood pressure.

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Cardiovascular Medicine

Member
Boston University
Whitaker Cardiovascular Institute


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Age-related Hypertension and Vascular Cognitive Impairment
02/01/2022 - 01/31/2027 (Multi-PI)
PI: Richard Wainford, PhD
NIH/National Institute on Aging
1R01AG075963-01

Aging and hypertension: Integrated renal and sympathetic control of blood pressure
09/30/2019 - 05/31/2024 (PI)
NIH/National Institute on Aging
5R01AG062515-04

Multidisciplinary Training in Cardiovascular Research
07/01/2016 - 06/30/2023 (Multi-PI)
PI: Richard Wainford, PhD
NIH/National Heart, Lung, and Blood Institute
5T32HL007224-45

Neural control of the kidney and long-term blood pressure regulation
06/01/2018 - 05/31/2023 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL139867-04

Central mechanisms and novel biomarkers of the salt-sensitivity of blood pressure
05/01/2018 - 02/28/2023 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL141406-04

Aging and hypertension: Integrated renal and sympathetic control of blood pressure
09/15/2018 - 08/31/2020 (PI)
NIH/National Institute on Aging
1R56AG057687-01A1

Porter Physiology Development Fellowship - Sympathetic Nervous System Regulation of the NCC in Salt Sensitive Hypertension (Franco Puleo)
09/01/2019 - 04/30/2020 (Key Person / Mentor)
PI: Franco Puleo
The American Physiological Society


Sympathetic Nervous System regulation of the NCC in Salt Sensitive Hypertension
07/01/2019 - 03/24/2020 (Key Person / Mentor)
PI: Franco Puleo
American Society Nephrology Foundation for Kidney Research


Neural Control of the Kidney and Blood Pressure Regulation
07/01/2017 - 06/30/2019 (PI)
American Heart Association


Mentoring in neural and Cardiorenal Pathophysiology
07/01/2016 - 06/30/2019 (PI)
American Heart Association


Showing 10 of 13 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2023 Age-related Hypertension and Vascular Cognitive Impairment 5R01AG075963-02
2022 Age-related Hypertension and Vascular Cognitive Impairment 1R01AG075963-01
2022 Aging and hypertension: Integrated renal and sympathetic control of blood pressure 5R01AG062515-04
2021 Aging and hypertension: Integrated renal and sympathetic control of blood pressure 5R01AG062515-03
2021 Neural control of the kidney and long-term blood pressure regulation 5R01HL139867-04 3
2021 Central mechanisms and novel biomarkers of the salt-sensitivity of blood pressure 5R01HL141406-04 4
2020 Aging and hypertension: Integrated renal and sympathetic control of blood pressure 5R01AG062515-02
2020 Aging and hypertension: Integrated renal and sympathetic control of blood pressure 3R01AG062515-02S1
2020 Neural control of the kidney and long-term blood pressure regulation 5R01HL139867-03 3
2020 Central mechanisms and novel biomarkers of the salt-sensitivity of blood pressure 5R01HL141406-03 4
Showing 10 of 29 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Schutte AE, Jafar TH, Poulter NR, Damasceno A, Khan NA, Nilsson PM, Alsaid J, Neupane D, Kario K, Beheiry H, Brouwers S, Burger D, Charchar FJ, Cho MC, Guzik TJ, Haji Al-Saedi GF, Ishaq M, Itoh H, Jones ESW, Khan T, Kokubo Y, Kotruchin P, Muxfeldt E, Odili A, Patil M, Ralapanawa U, Romero CA, Schlaich MP, Shehab A, Mooi CS, Steckelings UM, Stergiou G, Touyz RM, Unger T, Wainford RD, Wang JG, Williams B, Wynne BM, Tomaszewski M. Addressing global disparities in blood pressure control: perspectives of the International Society of Hypertension. Cardiovasc Res. 2022 Oct 11. PMID: 36219457; PMCID: PMC9619669; DOI: 10.1093/cvr/cvac130;
     
  2. Gnanenthiran SR, Borghi C, Burger D, Caramelli B, Charchar F, Chirinos JA, Cohen JB, Cremer A, Di Tanna GL, Duvignaud A, Freilich D, Gommans DHF, Gracia-Ramos AE, Murray TA, Pelorosso F, Poulter NR, Puskarich MA, Rizas KD, Rothlin R, Schlaich MP, Schreinlecher M, Steckelings UM, Sharma A, Stergiou GS, Tignanelli CJ, Tomaszewski M, Unger T, van Kimmenade RRJ, Wainford RD, Williams B, Rodgers A, Schutte AE. Renin-Angiotensin System Inhibitors in Patients With COVID-19: A Meta-Analysis of Randomized Controlled Trials Led by the International Society of Hypertension. J Am Heart Assoc. 2022 Sep 06; 11(17):e026143. PMID: 36000426; PMCID: PMC9496439; DOI: 10.1161/JAHA.122.026143;
     
  3. Amraei R, Moreira JD, Wainford RD. Central Gai2 Protein Mediated Neuro-Hormonal Control of Blood Pressure and Salt Sensitivity. Front Endocrinol (Lausanne). 2022; 13:895466.View Related Profiles. PMID: 35837296; PMCID: PMC9275552; DOI: 10.3389/fendo.2022.895466;
     
  4. Campbell NRC, Whelton PK, Orias M, Wainford RD, Cappuccio FP, Ide N, Neal B, Cohn J, Cobb LK, Webster J, Trieu K, He FJ, McLean RM, Blanco-Metzler A, Woodward M, Khan N, Kokubo Y, Nederveen L, Arcand J, MacGregor GA, Owolabi MO, Lisheng L, Parati G, Lackland DT, Charchar FJ, Williams B, Tomaszewski M, Romero CA, Champagne B, L'Abbe MR, Weber MA, Schlaich MP, Fogo A, Feigin VL, Akinyemi R, Inserra F, Menon B, Simas M, Neves MF, Hristova K, Pullen C, Pandeya S, Ge J, Jalil JE, Wang JG, Wideimsky J, Kreutz R, Wenzel U, Stowasser M, Arango M, Protogerou A, Gkaliagkousi E, Fuchs FD, Patil M, Chan AW, Nemcsik J, Tsuyuki RT, Narasingan SN, Sarrafzadegan N, Ramos ME, Yeo N, Rakugi H, Ramirez AJ, Álvarez G, Berbari A, Kim CI, Ihm SH, Chia YC, Unurjargal T, Park HK, Wahab K, McGuire H, Dashdorj NJ, Ishaq M, Ona DID, Mercado-Asis LB, Prejbisz A, Leenaerts M, Simão C, Pinto F, Almustafa BA, Spaak J, Farsky S, Lovic D, Zhang XH. 2022 World Hypertension League, Resolve To Save Lives and International Society of Hypertension dietary sodium (salt) global call to action. J Hum Hypertens. 2022 May 17; 1-10. PMID: 35581323; PMCID: PMC9110933; DOI: 10.1038/s41371-022-00690-0;
     
  5. Gkousioudi A, Yu X, Ferruzzi J, Qian J, Wainford RD, Seta F, Zhang Y. Biomechanical Properties of Mouse Carotid Arteries With Diet-Induced Metabolic Syndrome and Aging. Front Bioeng Biotechnol. 2022; 10:862996.View Related Profiles. PMID: 35392404; PMCID: PMC8980683; DOI: 10.3389/fbioe.2022.862996;
     
  6. Frame AA, Nist KM, Kim K, Kuwabara JT, Wainford RD. Natriuresis During an Acute Intravenous Sodium Chloride Infusion in Conscious Sprague Dawley Rats Is Mediated by a Blood Pressure-Independent a1-Adrenoceptor-Mediated Mechanism. Front Physiol. 2021; 12:784957.View Related Profiles. PMID: 35111076; PMCID: PMC8802910; DOI: 10.3389/fphys.2021.784957;
     
  7. Moreira JD, Nist KM, Carmichael CY, Kuwabara JT, Wainford RD. Sensory Afferent Renal Nerve Activated Gai2 Subunit Proteins Mediate the Natriuretic, Sympathoinhibitory and Normotensive Responses to Peripheral Sodium Challenges. Front Physiol. 2021; 12:771167.View Related Profiles. PMID: 34916958; PMCID: PMC8669768; DOI: 10.3389/fphys.2021.771167;
     
  8. Chaudhary P, Velkoska E, Wainford RD. An exploratory analysis of comparative plasma metabolomic and lipidomic profiling in salt-sensitive and salt-resistant individuals from The Dietary Approaches to Stop Hypertension Sodium Trial. J Hypertens. 2021 10 01; 39(10):1972-1981.View Related Profiles. PMID: 34001808; PMCID: PMC8429079; DOI: 10.1097/HJH.0000000000002904;
     
  9. Farris CW, Killiany RJ, O'Donoghue E, Koo BB, Wainford RD, Moss MB, Rosene DL, Moore TL. The relationship of age and hypertension with cognition and gray matter cerebral blood volume in a rhesus monkey model of human aging. Behav Neurosci. 2021 Oct; 135(5):680-692.View Related Profiles. PMID: 34197136
     
  10. Gnanenthiran SR, Borghi C, Burger D, Charchar F, Poulter NR, Schlaich MP, Steckelings UM, Stergiou G, Tomaszewski M, Unger T, Wainford RD, Williams B, Rodgers A, Schutte AE. Prospective meta-analysis protocol on randomised trials of renin-angiotensin system inhibitors in patients with COVID-19: an initiative of the International Society of Hypertension. BMJ Open. 2021 02 16; 11(2):e043625. PMID: 33593784; PMCID: PMC7887864; DOI: 10.1136/bmjopen-2020-043625;
     
Showing 10 of 59 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 59 publications over 15 distinct years, with a maximum of 9 publications in 2015 and 2020

YearPublications
20071
20083
20091
20101
20124
20131
20144
20159
20167
20172
20182
20195
20209
20214
20226

PVN Gal2 Subunit Proteins--The Key to a Salt-resistant Phenotype

The link between dementia and cardiovascular disease

Medical Xpress 11/6/2018

Experts gave advice on how to overcome dependence on sweets

The MiceTimes of Asia 5/27/2018

2014 The American Physiology Society: Arthur C. Guyton Award for Excellence in Integrative Physiology
2014 Howard Hughes Medical Institute (HHMI): Summer Research Program Award
2013 American Heart Association Council for High Blood Pressure: Research Harry Goldblatt New Investigator
2013 The American Physiological Society Central Nervous System: New Investigator Award
2013 Endocrine Society: Early Investigator Award
2013 The American Physiological Society: Shih-Chun Wang Young Investigator Award
2012 International Society of Hypertension: New Investigator of the Month (December)
2012 The American Physiological Society: Dean Franklin Young Investigator Award
2011 The American Physiological Society: Research Career Enhancement Award

Available to Mentor as: (Review Mentor Role Definitions):
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  • Career Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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