Richard H. Myers, PhD
Professor
Boston University School of Medicine
Dept of Neurology

PhD, Georgia State University
MA, Georgia State University
MEd, Georgia State University



My professional interests have focused upon the application of genetic research methods for the investigation of adult onset diseases with complex etiology (Parkinson’s disease, coronary heart disease, Alzheimer’s disease, pulmonary function, osteoarthritis, osteoporosis etc.). I have a long-standing interest in Huntington’s disease and have participated in a wide range of research investigations for this disease. I have been a member of the New England Huntington’s disease "Center Without Walls" since its inception in 1980. My HD studies may best be characterized as ‘Neurobiological Studies’ in that they include studies into the mechanisms of disease expression, including complex genetic modifier studies and a series of neuropathological studies of effects of disease expression in the brain. Additional interests are in the ethical issues influencing utilization of genetic test procedures.
I have been involved in a number of studies in positional cloning. I participated in the cloning of the gene for Huntington’s disease in 1993. I initiated the genome scan project in the Framingham Study, and a genome scan in Parkinson’s disease. My Parkinson’s disease genetic linkage study, known as the "GenePD" study, involves an international collaboration of twenty clinical centers in Parkinson’s disease. The study is seeking genetic loci involved in risk for PD. Since 1993 I have participated in genetic linkage studies for hypertension (the HyperGEN study, one of the NHLBI Family Blood Pressure Program Project studies), and the genome scan in the NHLBI Family Heart Study.

Director of Genome Science Institute
Boston University School of Medicine
Genome Science Institute


Aubrey Milunsky Chair in Human Genetics
Boston University School of Medicine
Medicine
Biomedical Genetics

Professor
Boston University School of Medicine
Medicine
Biomedical Genetics

Professor
Boston University School of Public Health
Environmental Health


Mentor for Graduate Medical Students
Boston University School of Medicine, Division of Graduate Medical Sciences


Boston Medical Center


Member
Boston University
Bioinformatics Graduate Program




Cyclin G-associated kinase as a novel target for Parkinson's disease
01/01/2017 - 12/31/2019 (PI)
Ellison Foundation


Functional analysis of Disease associated risk alleles in sporadic Parkinson's disease
09/23/2014 - 06/30/2019 (PI)
Whitehead Institute for Biomedical Research NIH NINDS
5R01NS088538-03

Probing the Dark Matter of the Genome in the NHLBI Family Heart Study
07/01/2016 - 06/30/2018 (PI)
Washington University NIH NHLBI
4R01HL117078-04

Epigenetic Markers in Huntington's Disease Brain
07/01/2011 - 04/30/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
3R01NS073947-05S1

Probing the Dark Matter of the Genome in the NHLBI Family Heart Study
07/22/2013 - 06/30/2016 (PI)
Washington University NIH NHLBI
5R01HL117078-03

Epigenetic Markers of Huntington Disease Brain
07/01/2011 - 04/30/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1 R01 NS073947 01

Characterization of the role of cyclin G-associated kinase in Parkinson disease
09/01/2011 - 04/30/2015 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS076843-03

Genomic Scan for Atherosclerosis Pathway Genes in African Americans from FHS Scan
05/15/2008 - 04/30/2013 (PI)
Washington University NIH NHLBI
5R01HL088215-04

Identifying Susceptibility Genes for Metabolic Syndrome
01/29/2007 - 12/31/2011 (PI)
Regents of the University of Minnesota NIH NIDDK
5R01DK068320-03

Mapping Adiposity QTLs in the NHLBI Family Heart Study
09/20/2004 - 06/30/2009 (PI)
Washington University, St Louis NIH NIDDK

Showing 10 of 12 results. Show All Results



Yr Title Project-Sub Proj Pubs
2017 An iPSC based platform for functionally assessing genetic and environmental risk 5R01NS088538-04 7
2016 An iPSC based platform for functionally assessing genetic and environmental risk 5R01NS088538-03 7
2015 An iPSC based platform for functionally assessing genetic and environmental risk 5R01NS088538-02 7
2015 Epigenetic Markers in Huntington's disease Brain 5R01NS073947-05 13
2015 Epigenetic Markers in Huntington's disease Brain 3R01NS073947-05S1 13
2014 An iPSC based platform for functionally assessing genetic and environmental risk 1R01NS088538-01 7
2014 Epigenetic Markers in Huntington's disease Brain 5R01NS073947-04 13
2013 Characterization of the role of cyclin G-associated kinase in Parkinson disease 5R01NS076843-03 6
2013 Epigenetic Markers in Huntington's disease Brain 5R01NS073947-03 13
2012 Characterization of the role of cyclin G-associated kinase in Parkinson disease 5R01NS076843-02 6
Showing 10 of 33 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Labadorf A, Choi SH, Myers RH. Evidence for a Pan-Neurodegenerative Disease Response in Huntington's and Parkinson's Disease Expression Profiles. Front Mol Neurosci. 2017; 10:430. PMID: 29375298.
     
  2. Hui KY, Fernandez-Hernandez H, Hu J, Schaffner A, Pankratz N, Hsu NY, Chuang LS, Carmi S, Villaverde N, Li X, Rivas M, Levine AP, Bao X, Labrias PR, Haritunians T, Ruane D, Gettler K, Chen E, Li D, Schiff ER, Pontikos N, Barzilai N, Brant SR, Bressman S, Cheifetz AS, Clark LN, Daly MJ, Desnick RJ, Duerr RH, Katz S, Lencz T, Myers RH, Ostrer H, Ozelius L, Payami H, Peter Y, Rioux JD, Segal AW, Scott WK, Silverberg MS, Vance JM, Ubarretxena-Belandia I, Foroud T, Atzmon G, Pe'er I, Ioannou Y, McGovern DPB, Yue Z, Schadt EE, Cho JH, Peter I. Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease. Sci Transl Med. 2018 Jan 10; 10(423). PMID: 29321258.
     
  3. Reed ER, Latourelle JC, Bockholt JH, Bregu J, Smock J, Paulsen JS, Myers RH. MicroRNAs in CSF as prodromal biomarkers for Huntington disease in the PREDICT-HD study. Neurology. 2018 Jan 23; 90(4):e264-e272.View Related Profiles. PMID: 29282329.
     
  4. Lee JM, Chao MJ, Harold D, Abu Elneel K, Gillis T, Holmans P, Jones L, Orth M, Myers RH, Kwak S, Wheeler VC, MacDonald ME, Gusella JF. A modifier of Huntington's disease onset at the MLH1 locus. Hum Mol Genet. 2017 Oct 01; 26(19):3859-3867. PMID: 28934397.
     
  5. Chao MJ, Gillis T, Atwal RS, Mysore JS, Arjomand J, Harold D, Holmans P, Jones L, Orth M, Myers RH, Kwak S, Wheeler VC, MacDonald ME, Gusella JF, Lee JM. Haplotype-based stratification of Huntington's disease. Eur J Hum Genet. 2017 Nov; 25(11):1202-1209. PMID: 28832564.
     
  6. Neueder A, Landles C, Ghosh R, Howland D, Myers RH, Faull RLM, Tabrizi SJ, Bates GP. The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patients. Sci Rep. 2017 05 02; 7(1):1307. PMID: 28465506.
     
  7. Choi SH, Labadorf AT, Myers RH, Lunetta KL, Dupuis J, DeStefano AL. Evaluation of logistic regression models and effect of covariates for case-control study in RNA-Seq analysis. BMC Bioinformatics. 2017 Feb 06; 18(1):91.View Related Profiles. PMID: 28166718; DOI: 10.1186/s12859-017-1498-y;.
     
  8. Labadorf A, Hoss AG, Myers RH. Neuroimmune Pharmacology. Huntington’s Disease. 2017. View Publication
     
  9. Wake C, Labadorf A, Dumitriu A, Hoss AG, Bregu J, Albrecht KH, DeStefano AL, Myers RH. Novel microRNA discovery using small RNA sequencing in post-mortem human brain. BMC Genomics. 2016 Oct 04; 17(1):776.View Related Profiles. PMID: 27716130.
     
  10. Trinh J, Gustavsson EK, Vilariño-Güell C, Bortnick S, Latourelle J, McKenzie MB, Tu CS, Nosova E, Khinda J, Milnerwood A, Lesage S, Brice A, Tazir M, Aasly JO, Parkkinen L, Haytural H, Foroud T, Myers RH, Sassi SB, Hentati E, Nabli F, Farhat E, Amouri R, Hentati F, Farrer MJ. DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study. Lancet Neurol. 2016 Nov; 15(12):1248-1256.View Related Profiles. PMID: 27692902; DOI: 10.1016/S1474-4422(16)30203-4;.
     
Showing 10 of 338 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 333 publications over 38 distinct years, with a maximum of 17 publications in 2002

YearPublications
19801
19824
19832
19844
19855
19862
19879
19884
198913
19905
19917
199212
199312
19947
19958
19966
199711
199812
199911
200016
200113
200217
200313
200410
200510
200616
200713
200815
20099
20106
20117
201213
20134
20146
201511
201611
20176
20182
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

coronary heart disease
genetic testing
Huntington's disease
Neurogenetics
Parkinson's disease
risk factors
Contact for Mentoring:


75 E. Newton St Evans Building
Boston MA 02118
Google Map


Myers's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department