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Benador IY, Veliova M, Mahdaviani K, Petcherski A, Wikstrom JD, Assali EA, Acín-Pérez R, Shum M, Oliveira MF, Cinti S, Sztalryd C, Barshop WD, Wohlschlegel JA, Corkey BE, Liesa M, Shirihai OS. Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion. Cell Metab. 2018 04 03; 27(4):869-885.e6.View Related Profiles. PMID: 29617645; PMCID: PMC5969538; DOI: 10.1016/j.cmet.2018.03.003;
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Jones Iv AR, Coleman EL, Husni NR, Deeney JT, Raval F, Steenkamp D, Dooms H, Nikolajczyk BS, Corkey BE. Type 1 diabetes alters lipid handling and metabolism in human fibroblasts and peripheral blood mononuclear cells. PLoS One. 2017; 12(12):e0188474.View Related Profiles. PMID: 29206239; PMCID: PMC5714353; DOI: 10.1371/journal.pone.0188474;
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Lamontagne J, Al-Mass A, Nolan CJ, Corkey BE, Madiraju SRM, Joly E, Prentki M. Identification of the signals for glucose-induced insulin secretion in INS1 (832/13) ß-cells using metformin-induced metabolic deceleration as a model. J Biol Chem. 2017 11 24; 292(47):19458-19468. PMID: 28972173; PMCID: PMC5702682; DOI: 10.1074/jbc.M117.808105;
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Schwartz SS, Epstein S, Corkey BE, Grant SFA, Gavin Iii JR, Aguilar RB, Herman ME. A Unified Pathophysiological Construct of Diabetes and its Complications. Trends Endocrinol Metab. 2017 09; 28(9):645-655. PMID: 28629897
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Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 2017 Jul; 18(7):1123-1138.View Related Profiles. PMID: 28539390; PMCID: PMC5887905; DOI: 10.15252/embr.201643827;
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Mugabo Y, Zhao S, Lamontagne J, Al-Mass A, Peyot ML, Corkey BE, Joly E, Madiraju SRM, Prentki M. Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic ß-cells. J Biol Chem. 2017 05 05; 292(18):7407-7422. PMID: 28280244; PMCID: PMC5418042; DOI: 10.1074/jbc.M116.763060;
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Erion K, Corkey BE. Hyperinsulinemia: a Cause of Obesity?. 2017. View Publication
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Lamontagne J, Al-Mass A, Nolan C, Corkey BE, Madiraju SRM, Joly E, Prentki M. Identification of the signals for glucose-induced insulin secretion in INS1 (832/13) ß-cells using metformin-induced metabolic deceleration as a model. Journal of Biological Chemistry. 2017; 292(47). View Publication
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Schwartz S, Epstein S, Corkey BE, Grant SFA, Gavin JR, Aguilar RB, Herman ME. A Unified Pathophysiological Construct of Diabetes and its Complications. Trends in Endocrinology and Metabolism. 2017; 28(9). View Publication
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Mugabo Y, Zhao S, Lamontagne J, Al-Mass A, Peyot ML, Corkey BE, Joly E, Murthy Madiraju SR, Prentki M. Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic ß-cells. Journal of Biological Chemistry. 2017; 292(18). View Publication
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Jones AR, Coleman EL, Husni NR, Deeney JT, Raval F, Steenkamp D, Dooms H, Nikolajczyk BS, Corkey BE. Type 1 diabetes alters lipid handling and metabolism in human fibroblasts and peripheral blood mononuclear cells. PLoS ONE. 2017; 12(12). View Publication
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Tulipani S, Griffin J, Palau-Rodriguez M, Mora-Cubillos X, Bernal-Lopez RM, Tinahones FJ, Corkey BE, Andres-Lacueva C. Metabolomics-guided insights on bariatric surgery versus behavioral interventions for weight loss. Obesity (Silver Spring). 2016 Dec; 24(12):2451-2466. PMID: 27891833
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Schwartz SS, Epstein S, Corkey BE, Grant SF, Gavin JR, Aguilar RB. Response to Comment on Schwartz et al. The Time Is Right for a New Classification System for Diabetes: Rationale and Implications of the ß-Cell-Centric Classification Schema. Diabetes Care 2016;39:179-186. Diabetes Care. 2016 08; 39(8):e129-30. PMID: 27457644
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Schwartz SS, Epstein S, Corkey BE, Grant SF, Gavin JR, Aguilar RB. The Time Is Right for a New Classification System for Diabetes: Rationale and Implications of the ß-Cell-Centric Classification Schema. Diabetes Care. 2016 Feb; 39(2):179-86. PMID: 26798148; PMCID: PMC5317235; DOI: 10.2337/dc15-1585;
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Schwartz S, Epstein S, Corkey BE, Grant SFA, Gavin JR, Aguilar RB. The Time Is Right for a New Classification System for Diabetes: Rationale and Implications of the ß-Cell–Centric Classification Schema. Diabetes Care. 2016; 39(2):179-186. View Publication
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Berdan CA, Erion K, Burritt NE, Corkey BE, Deeney JT. Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets. PLoS ONE. 2016; 11(2). View Publication
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Deeney JT, Belkina AC, Shirhai OS, Corkey BE, Denis GV. BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic ß-Cell. PLoS ONE. 2016; 11(3). View Publication
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Corkey BE. What causes type 2 diabetes?. 2016.
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Jones AR, Meshulam T, Oliveira M, Burritt N, Corkey BE. Extracellular Redox Regulation of Intracellular Reactive Oxygen Generation, Mitochondrial Function and Lipid Turnover in Cultured Human Adipocytes. PLoS ONE. 2016; 11(10). View Publication
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Pizarro-Delgado J, Deeney JT, Corkey BE, Tamarit-Rodriguez J. Direct Stimulation of Islet Insulin Secretion by Glycolytic and Mitochondrial Metabolites in KCl-Depolarized Islets. PLoS ONE. 2016; 11(11). View Publication
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Tulipani S, Griffin J, Palau M, Mora-Cubillos X, Bernal-Lopez M, Tinahones FJ, Corkey BE, Andres-Lacueva C. Metabolomics-guided insights on bariatric surgery versus behavioral interventions for weight loss: Metabolomics of Bariatric Versus Dietary Weight Loss. Obesity. 2016; 24(12):2451-2466. View Publication
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Pizarro-Delgado J, Deeney JT, Martín-del-Río R, Corkey BE, Tamarit-Rodriguez J. KCl -Permeabilized Pancreatic Islets: An Experimental Model to Explore the Messenger Role of ATP in the Mechanism of Insulin Secretion. PLoS One. 2015; 10(10):e0140096.View Related Profiles. PMID: 26444014; PMCID: PMC4596849; DOI: 10.1371/journal.pone.0140096;
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Kleckner AS, Wong S, Corkey BE. The Intra- or Extracellular Redox State Was Not Affected by a High vs. Low Glycemic Response Diet in Mice. PLoS One. 2015; 10(6):e0128380. PMID: 26030878; PMCID: PMC4451145; DOI: 10.1371/journal.pone.0128380;
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Erion KA, Berdan CA, Burritt NE, Corkey BE, Deeney JT. Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic ß-Cells. J Biol Chem. 2015 Jun 26; 290(26):16191-201.View Related Profiles. PMID: 25934392; PMCID: PMC4481219; DOI: 10.1074/jbc.M114.620351;
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Laflamme C, Jedrychowsk M, Erion K, Meshulam T, Gygi S, Corkey BE, Pilch P. Diabetes. Adiporedoxin, an Upstream Regulator of ER Oxidative Folding and Secreted Proteins in Adipocytes. 2015.
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Kleckner AS, Wong S, Corkey BE. The Intra- or Extracellular Redox State Was Not Affected by a High vs. Low Glycemic Response Diet in Mice. PLoS ONE. 2015; 10(6). View Publication
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Ireland KA, Manders AJ, Corkey BE, Lenders CM. Recruitment in a Pediatric Clinical Research Trial Targeting Underserved Populations: Efforts and Challenges. 2015. View Publication
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Pizarro-Delgado J, Deeney JT, Martin-del-Rio R, Corkey BE, Tamarit-Rodriguez J. KCl -Permeabilized Pancreatic Islets: An Experimental Model to Explore the Messenger Role of ATP in the Mechanism of Insulin Secretion. PLoS ONE. 2015; 10(10). View Publication
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Wikstrom JD, Mahdaviani K, Liesa M, Sereda SB, Si Y, Las G, Twig G, Petrovic N, Zingaretti C, Graham A, Cinti S, Corkey BE, Cannon B, Nedergaard J, Shirihai OS. Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure. EMBO J. 2014 Mar 3; 33(5):418-36.View Related Profiles. PMID: 24431221; PMCID: PMC3983686; DOI: 10.1002/embj.201385014;
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Kleckner AS, Schlezinger JJ, Corkey BE. What Are We Putting in Our Food That Is Making Us Fat? Food Additives, Contaminants, and Other Putative Contributors to Obesity. 2014. View Publication
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Schoeller DA, Thomas D, Archer E, Heymsfield SB, Blair SN, Goran MI, Hill JO, Atkinson RL, Corkey BE, Foreyt J, Dhurandhar NV, Kral JG, Hall KD, Hansen BC, Heitmann BL, Ravussin E, Allison DB. Self-report-based estimates of energy intake offer an inadequate basis for scientific conclusions. Am J Clin Nutr. 2013 Jun; 97(6):1413-5. PMID: 23689494; PMCID: PMC6546220; DOI: 10.3945/ajcn.113.062125;
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Corkey BE. Diabetes: have we got it all wrong? Insulin hypersecretion and food additives: cause of obesity and diabetes? Diabetes Care. 2012 Dec; 35(12):2432-7. PMID: 23173132; PMCID: PMC3507569; DOI: 10.2337/dc12-0825;
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Haller JF, Krawczyk SA, Gostilovitch L, Corkey BE, Zoeller RA. Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1a to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease. Biochim Biophys Acta. 2011 Nov; 1812(11):1393-402.View Related Profiles. PMID: 21787864; PMCID: PMC3185221; DOI: 10.1016/j.bbadis.2011.07.007;
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Zhong J, Krawczyk SA, Chaerkady R, Huang H, Goel R, Bader JS, Wong GW, Corkey BE, Pandey A. Temporal profiling of the secretome during adipogenesis in humans. J Proteome Res. 2010 Oct 1; 9(10):5228-38. PMID: 20707391; PMCID: PMC2948433; DOI: 10.1021/pr100521c;
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Getty-Kaushik L, Richard AM, Deeney JT, Krawczyk S, Shirihai O, Corkey BE. The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets. Obesity (Silver Spring). 2009 Oct; 17(10):1856-60.View Related Profiles. PMID: 19644453; PMCID: PMC3808997; DOI: 10.1038/oby.2009.234;
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Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS. Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes. 2009 Oct; 58(10):2303-15.View Related Profiles. PMID: 19581419; PMCID: PMC2750232; DOI: 10.2337/db07-1781;
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Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, Collins S, Andersen ME. ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicol Appl Pharmacol. 2010 Apr 1; 244(1):77-83. PMID: 19501608; PMCID: PMC2837798; DOI: 10.1016/j.taap.2009.05.025;
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Pi J, Bai Y, Daniel KW, Liu D, Lyght O, Edelstein D, Brownlee M, Corkey BE, Collins S. Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology. 2009 Jul; 150(7):3040-8. PMID: 19246534; PMCID: PMC2703519; DOI: 10.1210/en.2008-1642;
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Krawczyk SA, Haller JF, Deeney JT, Zoeller RA, Corkey BE. Obesity. NADPH Oxidase Regulates Lipid Synthesis in Human Differentiated Adipocytes. 2009.
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Liu L, Deeney JT, Kirber MT, Corkey BE. Obesity. NAD(P)H Enhances Insulin Secretion From Pancreatic beta-Cells, Comparing Glucose- and Methyl-Isocitrate (MIC) induced Insulin Secretion. 2009.
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Si Y, Corkey BE. Obesity. Inhibiting Pyruvate Carboxylase Decreased Lipid Accumulation in White Adipocytes. 2009.
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Molina A, Stiles L, Corkey BE, Shirihai O. Obesity. A Model of Pancreatic Beta Cell Mitochondrial Dysfunction Exhibits Dramatic Obesity and Diabetes. 2009.
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Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb; 14(2):144-53.View Related Profiles. PMID: 18223655; PMCID: PMC3918232; DOI: 10.1038/nm1717;
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Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008 Jan 23; 27(2):433-46.View Related Profiles. PMID: 18200046; PMCID: PMC2234339; DOI: 10.1038/sj.emboj.7601963;
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Adebamowo CA, Spiegelman D, Berkey CS, Danby FW, Rockett HH, Colditz GA, Willett WC, Holmes MD. Milk consumption and acne in teenaged boys. J Am Acad Dermatol. 2008 May; 58(5):787-93. PMID: 18194824; PMCID: PMC4391699; DOI: 10.1016/j.jaad.2007.08.049;
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Must A, Bandini LG, Tybor DJ, Janssen I, Ross R, Dietz WH. Behavioral risk factors in relation to visceral adipose tissue deposition in adolescent females. Int J Pediatr Obes. 2008; 3 Suppl 1:28-36. PMID: 18278630; PMCID: PMC2651741; DOI: 10.1080/17477160801896739;
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Corkey, B. E. (2008) Metabolic Regulation of Insulin Secretion, Monograph entitled “Pancreatic Beta Cell in Health and Disease,” Springer Japan KK (53-75). Metabolic Regulation of Insulin Secretion. Monograph entitled Pancreatic Beta Cell in Health and Disease. Springer. Japan KK. 2008; 53-75.
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Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Long-term effect of magnesium consumption on the risk of symptomatic gallstone disease among men. Am J Gastroenterol. 2008 Feb; 103(2):375-82. PMID: 18076730
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Trus M, Corkey RF, Nesher R, Richard AM, Deeney JT, Corkey BE, Atlas D. The L-type voltage-gated Ca2+ channel is the Ca2+ sensor protein of stimulus-secretion coupling in pancreatic beta cells. Biochemistry. 2007 Dec 18; 46(50):14461-7.View Related Profiles. PMID: 18027971
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Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS. beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes. 2007 Oct; 56(10):2569-78.View Related Profiles. PMID: 17686943
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Deeney JT, Bränström R, Corkey BE, Larsson O, Berggren PO. 3H-serotonin as a marker of oscillatory insulin secretion in clonal beta-cells (INS-1). FEBS Lett. 2007 Aug 21; 581(21):4080-4.View Related Profiles. PMID: 17686476
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Han JR, Deng B, Sun J, Chen CG, Corkey BE, Kirkland JL, Ma J, Guo W. Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects. Metabolism. 2007 Jul; 56(7):985-91.View Related Profiles. PMID: 17570262
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Guo W, Bigornia S, Leizerman I, Xie W, McDonnell M, Clemente K, Pirtskhalava T, Kirkland JL, Gokce N, Corkey BE, Sullivan LM, Apovian CM. New scanning electron microscopic method for determination of adipocyte size in humans and mice. Obesity (Silver Spring). 2007 Jul; 15(7):1657-65.View Related Profiles. PMID: 17636083
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Bränström R, Leibiger IB, Leibiger B, Klement G, Nilsson J, Arhem P, Aspinwall CA, Corkey BE, Larsson O, Berggren PO. Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: indications for a long-chain acyl-CoA ester binding motif. Diabetologia. 2007 Aug; 50(8):1670-7. PMID: 17522836
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Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE. Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose. Biochem J. 2007 Apr 1; 403(1):197-205.View Related Profiles. PMID: 17181533; PMCID: PMC1828901; DOI: 10.1042/BJ20061209;
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Pi J, Bai Y, Zhang Q, Wong V, Floering LM, Daniel K, Reece JM, Deeney JT, Andersen ME, Corkey BE, Collins S. Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes. 2007 Jul; 56(7):1783-91.View Related Profiles. PMID: 17400930
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Corkey, B. E. and Prentki, M. Malonyl CoA and Long Chain Acyl-CoA Signaling in Health, Obesity and Diabetes. Diabetes. 2007.
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Pi J, Bai Y, Daniel K, Otis L, Floering LM, Edelstein D, Brownlee M, Corkey BE, Collins S. Free Radical Biology and Medicine. Persistent oxidative stress due to absence of UCP2 impairs pancreatic beta-cell function. 2007.
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Wolfe MM, Song DH, Musson MC, Jepeal LI, Getty-Kaushik L, Singh SK, Corkey BE. Journal of Molecular Neuroscience. The obesity epidemic: Is the problem appetite or the efficient human eating machine?. 2007.
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Tu P, Wong S, Bigornia S, Corkey BE, Apovian C, Guo W. FATTY ACIDS ACTIVATE NUCLEAR FACTOR ?B AND INDUCE INTERLEUKIN-6 PRODUCTION FROM MOUSE 3T3-L1 PREADIPOCYTES AND ISOLATED HUMAN SUBCUTANEOUS STROMAL-VASCULAR CELLS. Journal of Investigative Medicine. 2007; 55(2):S359. View Publication
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Deeney JT, Liu L, Corkey R, Corkey BE. Diabetologia. The lipase inhibitor, orlistat blocks glucose-induced Ca2+ oscillations and insulin secretion from pancreatic B cells; Effects partially reversed by fatty acid. 2007.
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Guo W, Pirtskhalava T, Tchkonia T, Xie W, Thomou T, Han J, Wang T, Wong S, Cartwright A, Hegardt FG, Corkey BE, Kirkland JL. Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity. Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1041-51.View Related Profiles. PMID: 17148751
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Getty-Kaushik L, Song DH, Boylan MO, Corkey BE, Wolfe MM. Glucose-dependent insulinotropic polypeptide modulates adipocyte lipolysis and reesterification. Obesity (Silver Spring). 2006 Jul; 14(7):1124-31.View Related Profiles. PMID: 16899793
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Xie W, Hamilton JA, Kirkland JL, Corkey BE, Guo W. Oleate-induced formation of fat cells with impaired insulin sensitivity. Lipids. 2006 Mar; 41(3):267-71.View Related Profiles. PMID: 16711601
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Kirkland, J.L., Corkey, B.E., Tchkonia, T. Current views of the fat cell as an endocrine cell: lipotoxicity. Overweight and the Metabolic Syndrome, George A. Bray and Donna H. Ryan, Eds., Endocrine Updates. Springer. 2006; pp 105-123.
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Getty-Kaushik L, Richard AM, Corkey BE. Glucose-dependent insulin modulation of oscillatory lipolysis in perifused rat adipocytes. Obes Res. 2005 Dec; 13(12):2058-65. PMID: 16421338
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Heart E, Corkey RF, Wikstrom JD, Shirihai OS, Corkey BE. Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells. Am J Physiol Endocrinol Metab. 2006 Jan; 290(1):E143-E148.View Related Profiles. PMID: 16144817
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Zang Y, Wang T, Xie W, Wang-Fischer YL, Getty L, Han J, Corkey BE, Guo W. Regulation of acetyl CoA carboxylase and carnitine palmitoyl transferase-1 in rat adipocytes. Obes Res. 2005 Sep; 13(9):1530-9.View Related Profiles. PMID: 16222055
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Hu L, Deeney JT, Nolan CJ, Peyot ML, Ao A, Richard AM, Luc E, Faergeman NJ, Knudsen J, Guo W, Sorhede-Winzell M, Prentki M, Corkey BE. Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes. Am J Physiol Endocrinol Metab. 2005 Dec; 289(6):E1085-92.View Related Profiles. PMID: 16091387
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Getty-Kaushik L, Richard AM, Corkey BE. Free fatty acid regulation of glucose-dependent intrinsic oscillatory lipolysis in perifused isolated rat adipocytes. Diabetes. 2005 Mar; 54(3):629-37. PMID: 15734837
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Wang YL, Guo W, Zang Y, Yaney GC, Vallega G, Getty-Kaushik L, Pilch P, Kandror K, Corkey BE. Acyl coenzyme a synthetase regulation: putative role in long-chain acyl coenzyme a partitioning. Obes Res. 2004 Nov; 12(11):1781-8.View Related Profiles. PMID: 15601973
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Katzman SM, Messerli MA, Barry DT, Grossman A, Harel T, Wikstrom JD, Corkey BE, Smith PJ, Shirihai OS. Mitochondrial metabolism reveals a functional architecture in intact islets of Langerhans from normal and diabetic Psammomys obesus. Am J Physiol Endocrinol Metab. 2004 Dec; 287(6):E1090-9.View Related Profiles. PMID: 15339741
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Peyot ML, Nolan CJ, Soni K, Joly E, Lussier R, Corkey BE, Wang SP, Mitchell GA, Prentki M. Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1. Diabetes. 2004 Jul; 53(7):1733-42. PMID: 15220197
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Perdomo G, Commerford SR, Richard AM, Adams SH, Corkey BE, O'Doherty RM, Brown NF. Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation. J Biol Chem. 2004 Jun 25; 279(26):27177-86. PMID: 15105415
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Lei T, Xie W, Han J, Corkey BE, Hamilton JA, Guo W. Medium-chain Fatty acids attenuate agonist-stimulated lipolysis, mimicking the effects of starvation. Obes Res. 2004 Apr; 12(4):599-611.View Related Profiles. PMID: 15090627
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Bränström R, Aspinwall CA, Välimäki S, Ostensson CG, Tibell A, Eckhard M, Brandhorst H, Corkey BE, Berggren PO, Larsson O. Long-chain CoA esters activate human pancreatic beta-cell KATP channels: potential role in Type 2 diabetes. Diabetologia. 2004 Feb; 47(2):277-83. PMID: 14740158
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Song DI, Simon J, Getty L, Corkey BE, Wolfe MM. Gastroenterology. Characterization of glucose-dependent insulinotropic polypeptide (GIP) signaling in adipocytes and pancreatic islet beta-cells. 2004.
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Kamp F, Kizilbash N, Corkey BE, Berggren PO, Hamilton JA. Sulfonylureas rapidly cross phospholipid bilayer membranes by a free-diffusion mechanism. Diabetes. 2003 Oct; 52(10):2526-31.View Related Profiles. PMID: 14514636
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Yaney GC, Corkey BE. Fatty acid metabolism and insulin secretion in pancreatic beta cells. Diabetologia. 2003 Oct; 46(10):1297-312. PMID: 13680127
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Guo W, Lei T, Wang T, Corkey BE, Han J. Octanoate inhibits triglyceride synthesis in 3T3-L1 and human adipocytes. J Nutr. 2003 Aug; 133(8):2512-8.View Related Profiles. PMID: 12888629
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Wang T, Zang Y, Ling W, Corkey BE, Guo W. Metabolic partitioning of endogenous fatty acid in adipocytes. Obes Res. 2003 Jul; 11(7):880-7.View Related Profiles. PMID: 12855758
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Han J, Hamilton JA, Kirkland JL, Corkey BE, Guo W. Medium-chain oil reduces fat mass and down-regulates expression of adipogenic genes in rats. Obes Res. 2003 Jun; 11(6):734-44.View Related Profiles. PMID: 12805394
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Cunningham BA, Richard AM, Dillon JS, Daley JT, Civelek VN, Deeney JT, Yaney GC, Corkey BE, Tornheim K. Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets. Biochem J. 2003 Jan 1; 369(Pt 1):173-8.View Related Profiles. PMID: 12356335; PMCID: PMC1223070
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Corkey BE, Getty L. Diabetes. Fatty acid regulation of oscillatory lipolysis in perifused rat adipocytes. 2003.
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Guo W, Xie WS, Lei TG, Hamilton J, Kirkland J, Corkey BE, Han J. Obesity research. MCFA mediates a starvation-like metabolic status in adipocytes. 2003.
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Wolfe MM, Boylan M, Corkey BE. Glucose-dependent insulinotropic polypeptide (GIP) promotes triglyceride synthesis in adipocytes. Gastroenterology. 2003; 124. View Publication
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Kamp F, Guo W, Souto R, Pilch PF, Corkey BE, Hamilton JA. Rapid flip-flop of oleic acid across the plasma membrane of adipocytes. J Biol Chem. 2003 Mar 7; 278(10):7988-95.View Related Profiles. PMID: 12499383
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Yaney GC, Fairbanks JM, Deeney JT, Korchak HM, Tornheim K, Corkey BE. Potentiation of insulin secretion by phorbol esters is mediated by PKC-alpha and nPKC isoforms. Am J Physiol Endocrinol Metab. 2002 Nov; 283(5):E880-8.View Related Profiles. PMID: 12376314
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Alarcon C, Wicksteed B, Prentki M, Corkey BE, Rhodes CJ. Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation. Diabetes. 2002 Aug; 51(8):2496-504. PMID: 12145163
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Han J, Farmer SR, Kirkland JL, Corkey BE, Yoon R, Pirtskhalava T, Ido Y, Guo W. Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes. J Nutr. 2002 May; 132(5):904-10.View Related Profiles. PMID: 11983812
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Corkey BE. The state of the obesity epidemic. Current Opinion in Endocrinology and Diabetes. 2002; 9(5):367-368. View Publication
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Korchak HM, Corkey BE, Yaney GC, Kilpatrick LE. Negative regulation of ligand-initiated Ca(2+) uptake by PKC-beta II in differentiated HL60 cells. Am J Physiol Cell Physiol. 2001 Aug; 281(2):C514-23. PMID: 11443050
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Deeney JT, Köhler M, Kubik K, Brown G, Schultz V, Tornheim K, Corkey BE, Berggren PO. Glucose-induced metabolic oscillations parallel those of Ca(2+) and insulin release in clonal insulin-secreting cells. A multiwell approach to oscillatory cell behavior. J Biol Chem. 2001 Oct 5; 276(40):36946-50.View Related Profiles. PMID: 11481328
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Faradji RN, Havari E, Chen Q, Gray J, Tornheim K, Corkey BE, Mulligan RC, Lipes MA. Glucose-induced toxicity in insulin-producing pituitary cells that coexpress GLUT2 and glucokinase. Implications for metabolic engineering. J Biol Chem. 2001 Sep 28; 276(39):36695-702.View Related Profiles. PMID: 11443115
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Hamilton JA, Johnson RA, Corkey B, Kamp F. Fatty acid transport: the diffusion mechanism in model and biological membranes. J Mol Neurosci. 2001 Apr-Jun; 16(2-3):99-108; discussion 151-7.View Related Profiles. PMID: 11478390
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Caserta F, Tchkonia T, Civelek VN, Prentki M, Brown NF, McGarry JD, Forse RA, Corkey BE, Hamilton JA, Kirkland JL. Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes. Am J Physiol Endocrinol Metab. 2001 Feb; 280(2):E238-47.View Related Profiles. PMID: 11158926
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Yaney GC, Civelek VN, Richard AM, Dillon JS, Deeney JT, Hamilton JA, Korchak HM, Tornheim K, Corkey BE, Boyd AE. Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT). Diabetes. 2001 Jan; 50(1):56-62.View Related Profiles. PMID: 11147795
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Prentki, M., Roduit, R., Lameloise, N., Corkey, B. E. and Assimacopoulos-Jeannet, F. . Glucotoxicity, lipotoxicity and pancreatic ß-cell failure: A role for malonyl CoA, PPARa and altered lipid partitioning?. Can. J. Diabetes Care. 2001; 25:36-46.
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Deeney JT, Richard AMT, Foy R, Singh A, Schultz V, Yaney G, Tornheim K, Corkey BE. Inhibition of glucose-induced insulin release by triacsin C in clonal pancreatic beta-cells (HIT): Support for the "Long-Chain Acyl-CoA hypothesis". Diabetes. 2001.
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Dillon JS, Yaney GC, Zhou Y, Voilley N, Bowen S, Chipkin S, Bliss CR, Schultz V, Schuit FC, Prentki M, Waxman DJ, Corkey BE. Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells. Diabetes. 2000 Dec; 49(12):2012-20.View Related Profiles. PMID: 11118002
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Porterfield DM, Corkey RF, Sanger RH, Tornheim K, Smith PJ, Corkey BE. Oxygen consumption oscillates in single clonal pancreatic beta-cells (HIT). Diabetes. 2000 Sep; 49(9):1511-6.View Related Profiles. PMID: 10969835
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Deeney JT, Prentki M, Corkey BE. Metabolic control of beta-cell function. Semin Cell Dev Biol. 2000 Aug; 11(4):267-75.View Related Profiles. PMID: 10966860
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Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA. Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate. Biochem J. 2000 Jul 15; 349(Pt 2):463-71.View Related Profiles. PMID: 10880345; PMCID: PMC1221169
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Yaney GC, Korchak HM, Corkey BE. Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells. Endocrinology. 2000 Jun; 141(6):1989-98. PMID: 10830281
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Farfari S, Schulz V, Corkey B, Prentki M. Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion. Diabetes. 2000 May; 49(5):718-26. PMID: 10905479
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Deeney JT, Gromada J, Høy M, Olsen HL, Rhodes CJ, Prentki M, Berggren PO, Corkey BE. Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells). J Biol Chem. 2000 Mar 31; 275(13):9363-8.View Related Profiles. PMID: 10734079
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Brown H, Meister B, Deeney J, Corkey BE, Yang SN, Larsson O, Rhodes CJ, Seino S, Berggren PO, Fried G. Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis. Diabetes. 2000 Mar; 49(3):383-91.View Related Profiles. PMID: 10868959
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Corkey BE, Deeney JT, Yaney GC, Tornheim K, Prentki M. The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction. J Nutr. 2000 Feb; 130(2S Suppl):299S-304S.View Related Profiles. PMID: 10721892
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Corkey, B. E., Deeney, J. T., Yaney, G. C., Tornheim, K. and Prentki, M. . The Role of Long Chain Fatty Acyl CoA Esters in ß-Cell Signal Transduction. J. Nutr. 2000; 130:299S-304S.
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Faradjii RN, Havari E, Moriarty M, Mulligan RC, Corkey BE, Lipes MA. Analysis of the metabolic requirements for the creation of immunoresistant ß cell surrogates. Diabetes Research and Clinical Practice. 2000; 50(1):184. View Publication
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Getty L, Richard AM, Corkey BE. Rapid oscillatory lipolysis in isolated perifused adipocytes. Obesity research. 2000.
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Corkey BE. Obesity and nutrition. Current Opinion in Endocrinology and Diabetes. 2000; 7(5):217. View Publication
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Segall L, Lameloise N, Assimacopoulos-Jeannet F, Roche E, Corkey P, Thumelin S, Corkey BE, Prentki M. Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells. Am J Physiol. 1999 Sep; 277(3 Pt 1):E521-8. PMID: 10484365
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Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA. Incorporation of [1-13C]oleate into cellular triglycerides in differentiating 3T3L1 cells. Lipids. 1999 Aug; 34(8):825-31.View Related Profiles. PMID: 10529093
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Prentki, M., Segall, L., Roche, E., Thumelin, S., Brun, T., McGarry, J. D., Corkey, B. E. et Assimacopoulos-Jeannet, F. Gluco-lipotoxicité et expression génique dans la cellule ß-pancréatique. Diabète et Metabolism. 1999; 17-27.
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Bränström R, Leibiger IB, Leibiger B, Corkey BE, Berggren PO, Larsson O. Long chain coenzyme A esters activate the pore-forming subunit (Kir6. 2) of the ATP-regulated potassium channel. J Biol Chem. 1998 Nov 20; 273(47):31395-400. PMID: 9813050
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Gribble FM, Proks P, Corkey BE, Ashcroft FM. Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA. J Biol Chem. 1998 Oct 9; 273(41):26383-7. PMID: 9756869
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Brown H, Larsson O, Bränström R, Yang SN, Leibiger B, Leibiger I, Fried G, Moede T, Deeney JT, Brown GR, Jacobsson G, Rhodes CJ, Braun JE, Scheller RH, Corkey BE, Berggren PO, Meister B. Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis. EMBO J. 1998 Sep 1; 17(17):5048-58.View Related Profiles. PMID: 9724640; PMCID: PMC1170832
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Roche E, Farfari S, Witters LA, Assimacopoulos-Jeannet F, Thumelin S, Brun T, Corkey BE, Saha AK, Prentki M. Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression. Diabetes. 1998 Jul; 47(7):1086-94. PMID: 9648832
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Guo W, Kirkland JL, Corkey B, Hamilton JA. A 13C nuclear magnetic resonance study of free fatty acid incorporation in acylated lipids in differentiating preadipocytes. Lipids. 1998 May; 33(5):449-54.View Related Profiles. PMID: 9625591
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Skelly RH, Bollheimer LC, Wicksteed BL, Corkey BE, Rhodes CJ. A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties. Biochem J. 1998 Apr 15; 331 ( Pt 2):553-61. PMID: 9531497; PMCID: PMC1219388
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Prentki M, Segall L, Roche E, Thumelin S, Brun T, McGarry JD, Corkey BE, Assimacopoulos-Jeannet F. [Gluco-lipotoxicity and gene expression in the pancreatic beta cell]. Journ Annu Diabetol Hotel Dieu. 1998; 17-27. PMID: 9773607
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Guo W, Kirkland JL, Corkey BE, Hamilton JA. A 13C nuclear magnetic resonance study of free fatty acid incorporation in acylated lipids in differentiating predipocytes. Lipids. 1998; 33(5):449-454. View Publication
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Husni NR, Corkey BE. Tumor necrosis factor alpha and oleic acid alter calcium signal transduction in fibroblasts from type 1 diabetics. Diabetologia. 1998; 41.
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Brown NF, Hill JK, Esser V, Kirkland JL, Corkey BE, Foster DW, McGarry JD. Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes. Biochem J. 1997 Oct 1; 327 ( Pt 1):225-31. PMID: 9355756; PMCID: PMC1218784
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Bränström R, Corkey BE, Berggren PO, Larsson O. Evidence for a unique long chain acyl-CoA ester binding site on the ATP-regulated potassium channel in mouse pancreatic beta cells. J Biol Chem. 1997 Jul 11; 272(28):17390-4. PMID: 9211879
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Grujic D, Susulic VS, Harper ME, Himms-Hagen J, Cunningham BA, Corkey BE, Lowell BB. Beta3-adrenergic receptors on white and brown adipocytes mediate beta3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake. A study using transgenic and gene knockout mice. J Biol Chem. 1997 Jul 11; 272(28):17686-93. PMID: 9211919
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Prentki M, Tornheim K, Corkey BE. Signal transduction mechanisms in nutrient-induced insulin secretion. Diabetologia. 1997 Jul; 40 Suppl 2:S32-41.View Related Profiles. PMID: 9248699
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Hosokawa H, Corkey BE, Leahy JL. Beta-cell hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids. Diabetologia. 1997 Apr; 40(4):392-7. PMID: 9112015
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Lieu YK, Hsu BY, Price WA, Corkey BE, Stanley CA. Carnitine effects on coenzyme A profiles in rat liver with hypoglycin inhibition of multiple dehydrogenases. Am J Physiol. 1997 Mar; 272(3 Pt 1):E359-66. PMID: 9124539
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Brun T, Assimacopoulos-Jeannet F, Corkey BE, Prentki M. Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1. Diabetes. 1997 Mar; 46(3):393-400. PMID: 9032094
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Roche E, Assimacopoulos-Jeannet F, Witters LA, Perruchoud B, Yaney G, Corkey B, Asfari M, Prentki M. Induction by glucose of genes coding for glycolytic enzymes in a pancreatic beta-cell line (INS-1). J Biol Chem. 1997 Jan 31; 272(5):3091-8. PMID: 9006960
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Roche E, Assimacopoulos-Jeannet F, Witters LA, Perruchoud B, Thumelin S, Yaney G, Asfari M, Brun T, Corkey BE, Prentki M. Glucose causes a coordinated induction of glycolytic and lipogenic genes in beta(INS-1) CELLS. Diabetologia. 1997; 40:160.
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Civelek VN, Deeney JT, Fusonie GE, Corkey BE, Tornheim K. Oscillations in oxygen consumption by permeabilized clonal pancreatic beta-cells (HIT) incubated in an oscillatory glycolyzing muscle extract: roles of free Ca2+, substrates, and the ATP/ADP ratio. Diabetes. 1997 Jan; 46(1):51-6.View Related Profiles. PMID: 8971081; PMCID: PMC3346292
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Prentki, M., Tornheim, K. and Corkey, B. E. Signal transduction mechanisms in nutrient-induced secretion. Diabetologia. 1997; 40:S32-S41.
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Cunningham BA, Deeney JT, Bliss CR, Corkey BE, Tornheim K. Glucose-induced oscillatory insulin secretion in perifused rat pancreatic islets and clonal beta-cells (HIT). Am J Physiol. 1996 Oct; 271(4 Pt 1):E702-10.View Related Profiles. PMID: 8897858
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Civelek VN, Hamilton JA, Tornheim K, Kelly KL, Corkey BE. Intracellular pH in adipocytes: effects of free fatty acid diffusion across the plasma membrane, lipolytic agonists, and insulin. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10139-44.View Related Profiles. PMID: 8816765; PMCID: PMC38350
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Civelek VN, Deeney JT, Shalosky NJ, Tornheim K, Hansford RG, Prentki M, Corkey BE. Regulation of pancreatic beta-cell mitochondrial metabolism: influence of Ca2+, substrate and ADP. Biochem J. 1996 Sep 1; 318 ( Pt 2):615-21.View Related Profiles. PMID: 8809055; PMCID: PMC1217665
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Deeney JT, Cunningham BA, Chheda S, Bokvist K, Juntti-Berggren L, Lam K, Korchak HM, Corkey BE, Berggren PO. Reversible Ca2+-dependent translocation of protein kinase C and glucose-induced insulin release. J Biol Chem. 1996 Jul 26; 271(30):18154-60.View Related Profiles. PMID: 8663368
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Larsson O, Deeney JT, Bränström R, Berggren PO, Corkey BE. Activation of the ATP-sensitive K+ channel by long chain acyl-CoA. A role in modulation of pancreatic beta-cell glucose sensitivity. J Biol Chem. 1996 May 3; 271(18):10623-6.View Related Profiles. PMID: 8631866
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Civelek VN, Deeney JT, Kubik K, Schultz V, Tornheim K, Corkey BE. Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic beta-cells (HIT). Biochem J. 1996 May 1; 315 ( Pt 3):1015-9.View Related Profiles. PMID: 8645138; PMCID: PMC1217255
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Kurowski TG, Saha AK, Cunningham BA, Holbert RI, Colca JR, Corkey BE, Ruderman NB. Malonyl coenzyme A and adiposity in the Dahl salt-sensitive rat: effects of pioglitazone. Metabolism. 1996 Apr; 45(4):519-25.View Related Profiles. PMID: 8609842
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Prentki M, Corkey BE. Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes. 1996 Mar; 45(3):273-83. PMID: 8593930
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Nilsson T, Schultz V, Berggren PO, Corkey BE, Tornheim K. Temporal patterns of changes in ATP/ADP ratio, glucose 6-phosphate and cytoplasmic free Ca2+ in glucose-stimulated pancreatic beta-cells. Biochem J. 1996 Feb 15; 314 ( Pt 1):91-4.View Related Profiles. PMID: 8660314; PMCID: PMC1217056
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Brun T, Roche E, Assimacopoulos-Jeannet F, Corkey BE, Kim KH, Prentki M. Evidence for an anaplerotic/malonyl-CoA pathway in pancreatic beta-cell nutrient signaling. Diabetes. 1996 Feb; 45(2):190-8. PMID: 8549864
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Prentki, M. and Corkey, B. E. Are the ß-Cell Signaling Molecules, Malonyl and Cytosolic Long Chain Acyl-CoA, Implicated in Multiple Tissue Defects of Obesity and NIDDM?. Diabetes. 1996; 45:273-283.
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Prentki M, Corkey BE. Perspectives in Diabetes Are the P-Cell Signaling Molecules Malonyl-CoA and Cytosolic Long-Chain Acyl-CoA Implicated in Multiple Tissue Defects of Obesity and NIDDM?. 1996.
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Yaney GC, Schultz V, Cunningham BA, Dunaway GA, Corkey BE, Tornheim K. Phosphofructokinase isozymes in pancreatic islets and clonal beta-cells (INS-1). Diabetes. 1995 Nov; 44(11):1285-9.View Related Profiles. PMID: 7589825
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Korchak HM, Kane LH, Rossi MW, Corkey BE. Long chain acyl coenzyme A and signaling in neutrophils. An inhibitor of acyl coenzyme A synthetase, triacsin C, inhibits superoxide anion generation and degranulation by human neutrophils. J Biol Chem. 1994 Dec 2; 269(48):30281-7. PMID: 7982939
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Olszewski S, Deeney JT, Schuppin GT, Williams KP, Corkey BE, Rhodes CJ. Rab3A effector domain peptides induce insulin exocytosis via a specific interaction with a cytosolic protein doublet. J Biol Chem. 1994 Nov 11; 269(45):27987-91.View Related Profiles. PMID: 7961732
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Hamilton JA, Civelek VN, Kamp F, Tornheim K, Corkey BE. Changes in internal pH caused by movement of fatty acids into and out of clonal pancreatic beta-cells (HIT). J Biol Chem. 1994 Aug 19; 269(33):20852-6.View Related Profiles. PMID: 8063701
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Juntti-Berggren L, Civelek VN, Berggren PO, Schultz V, Corkey BE, Tornheim K. Glucose-stimulated increase in cytoplasmic pH precedes increase in free Ca2+ in pancreatic beta-cells. A possible role for pyruvate. J Biol Chem. 1994 May 20; 269(20):14391-5.View Related Profiles. PMID: 8182044
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Nachiappan V, Curtiss D, Corkey BE, Kilpatrick L. Cytokines inhibit fatty acid oxidation in isolated rat hepatocytes: synergy among TNF, IL-6, and IL-1. Shock. 1994 Feb; 1(2):123-9. PMID: 7749930
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Corkey, B. E., Deeney, J. T., Varnum, B. A., Civelek, V., Tornheim, K. and Prentki, M. Metabolic basis for glucose-induced insulin secretion in pancreatic ß-cells. Frontiers of Pancreatic ß-Cell Research (ed, P. R. Flatt). 1994; pp 91-96.
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Juntti-Berggren, L., Tornheim, K., Corkey, B. E. and Berggren, P.-O. Regulation of intracellular pH in the pancreatic ß-cell. Frontiers of Pancreatic ß-Cell Research (ed, P. R. Flatt). 1994; pp 145-151.
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Nur Civelek V, Friel J, Efendic S, Hamilton JA, Tornheim K, Kelly KL, Corkey BE. Diabetologia. Intracellular pH - An Early Postreceptor Insulin Signal In Adipocytes. 1994; 37(suppl):A1-A219.
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Deeney JT, Tornheim K, Korchak HM, Prentki M, Corkey BE. Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells. J Biol Chem. 1992 Oct 5; 267(28):19840-5.View Related Profiles. PMID: 1400300
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Hopkins WF, Fatherazi S, Peter-Riesch B, Corkey BE, Cook DL. Two sites for adenine-nucleotide regulation of ATP-sensitive potassium channels in mouse pancreatic beta-cells and HIT cells. J Membr Biol. 1992 Sep; 129(3):287-95. PMID: 1433280
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Prentki M, Vischer S, Glennon MC, Regazzi R, Deeney JT, Corkey BE. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion. J Biol Chem. 1992 Mar 25; 267(9):5802-10.View Related Profiles. PMID: 1556096
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Corkey BE, Nur Civelek V, Fusonie GE, Deeney JT, Shalosky NJ, Prentki M, Tornheim K. Diabetes. Stimulation of mitochondrial respiration by cytosolic signals in pancreatic ß-cells. 1992.
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Gilbert RJ, Valente G, Deeney JT, Corkey BE. ATP-dependent control of steady-state cytosolic calcium in cultured gastric smooth muscle. Am J Physiol. 1991 Oct; 261(4 Pt 1):G634-40.View Related Profiles. PMID: 1928349
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Longo EA, Tornheim K, Deeney JT, Varnum BA, Tillotson D, Prentki M, Corkey BE. Oscillations in cytosolic free Ca2+, oxygen consumption, and insulin secretion in glucose-stimulated rat pancreatic islets. J Biol Chem. 1991 May 15; 266(14):9314-9.View Related Profiles. PMID: 1902835
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Majumdar S, Rossi MW, Fujiki T, Phillips WA, Disa S, Queen CF, Johnston RB, Rosen OM, Corkey BE, Korchak HM. Protein kinase C isotypes and signaling in neutrophils. Differential substrate specificities of a translocatable calcium- and phospholipid-dependent beta-protein kinase C and a phospholipid-dependent protein kinase which is inhibited by long chain fatty acyl coenzyme A. J Biol Chem. 1991 May 15; 266(14):9285-94. PMID: 2026625
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Corkey BE, Geschwind JF, Deeney JT, Hale DE, Douglas SD, Kilpatrick L. Ca2+ responses to interleukin 1 and tumor necrosis factor in cultured human skin fibroblasts. Possible implications for Reye syndrome. J Clin Invest. 1991 Mar; 87(3):778-86.View Related Profiles. PMID: 1847937; PMCID: PMC329865
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13. Prentki, M., Visher, S., Brun, T., Glennon, M. C. and Corkey, B. E. Metabolic coupling factors in ß-cell insulin secretion. Diabetes 1991 (eds. H. Rifkin, J. A. Colwell, S. I. Taylor). Elsevier. Amsterdam. 1991; pp 156-160.
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McCormack JG, Longo EA, Corkey BE. Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets. Biochem J. 1990 Apr 15; 267(2):527-30. PMID: 2185742; PMCID: PMC1131320
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Corkey BE, Deeney JT. Acyl CoA regulation of metabolism and signal transduction. Prog Clin Biol Res. 1990; 321:217-32.View Related Profiles. PMID: 2183233
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Corkey BE, Glennon MC, Chen KS, Deeney JT, Matschinsky FM, Prentki M. A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells. J Biol Chem. 1989 Dec 25; 264(36):21608-12.View Related Profiles. PMID: 2689441
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Kelly KL, Deeney JT, Corkey BE. Cytosolic free calcium in adipocytes. Distinct mechanisms of regulation and effects on insulin action. J Biol Chem. 1989 Aug 5; 264(22):12754-7.View Related Profiles. PMID: 2666413
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Geschwind JF, Hiriart M, Glennon MC, Najafi H, Corkey BE, Matschinsky FM, Prentki M. Selective activation of Ca2+ influx by extracellular ATP in a pancreatic beta-cell line (HIT). Biochim Biophys Acta. 1989 Jun 15; 1012(1):107-15. PMID: 2543452
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Corkey, B. E., Tornheim, K., Deeney, J.T., Glennon, M.C., Matschinsky, F.M., Ruderman, N.B. and Prentki, M. . Integrated mitochondrial and microsomal regulation of free Ca2+ in permeabilized insulinoma cells. Integration of Mitochondrial Function (ed. J. J. Lemasters, C.R. Hockenbrock, R.G. Thurman and H.V. Westerhoff). Plenum. New York. 1989; pp 543-550.
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Corkey, B. E., Tornheim, K., Deeney, J.T., Glennon, M.C., Matschinsky, F.M., Ruderman, N.B. and Prentki, M. Metabolic regulation of Ca2+ handling in permeabilized insulinoma cells. Cell Calcium Metabolism '87 (ed. G. Fiskum). Plenum. New York. 1989; pp 369-377.
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Matschinsky, F. M., Corkey, B. E., Prentki, M., Meglasson, M. D., Erecinska, M., Shimazu, T., Ghosh, A. and Parker, J. Metabolic connectivity and signaling in pancreatic ß-cells. Diabetes 1988 (eds. R. G. Larkins, P. Z. Zimmet, and D. J. Chisholm). Excerpta Medica. Amsterdam. 1989; pp 17-26.
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Kilpatrick LE, Polin RA, Douglas SD, Corkey BE. Hepatic metabolic alterations in rats treated with low-dose endotoxin and aspirin: an animal model of Reye's syndrome. Metabolism. 1989 Jan; 38(1):73-7. PMID: 2909830
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Corkey BE, Hale DE, Glennon MC, Kelley RI, Coates PM, Kilpatrick L, Stanley CA. Relationship between unusual hepatic acyl coenzyme A profiles and the pathogenesis of Reye syndrome. J Clin Invest. 1988 Sep; 82(3):782-8. PMID: 3417871; PMCID: PMC303583
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Prentki M, Glennon MC, Thomas AP, Morris RL, Matschinsky FM, Corkey BE. Cell-specific patterns of oscillating free Ca2+ in carbamylcholine-stimulated insulinoma cells. J Biol Chem. 1988 Aug 15; 263(23):11044-7. PMID: 2841314
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Corkey BE, Deeney JT, Glennon MC, Matschinsky FM, Prentki M. Regulation of steady-state free Ca2+ levels by the ATP/ADP ratio and orthophosphate in permeabilized RINm5F insulinoma cells. J Biol Chem. 1988 Mar 25; 263(9):4247-53.View Related Profiles. PMID: 2831224
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Corkey BE, Tornheim K, Deeney JT, Glennon MC, Parker JC, Matschinsky FM, Ruderman NB, Prentki M. Linked oscillations of free Ca2+ and the ATP/ADP ratio in permeabilized RINm5F insulinoma cells supplemented with a glycolyzing cell-free muscle extract. J Biol Chem. 1988 Mar 25; 263(9):4254-8.View Related Profiles. PMID: 2831225
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Corkey, B. E. Analysis of acyl CoA esters in biological samples. Methods Enzymol. 1988; 166:55-70.
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Corkey BE. Analysis of acyl-coenzyme A esters in biological samples. Methods Enzymol. 1988; 166:55-70. PMID: 3241570
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Prentki M, Glennon MC, Geschwind JF, Matschinsky FM, Corkey BE. Cyclic AMP raises cytosolic Ca2+ and promotes Ca2+ influx in a clonal pancreatic beta-cell line (HIT T-15). FEBS Lett. 1987 Aug 10; 220(1):103-7. PMID: 2440720
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Mato JM, Kelly KL, Abler A, Jarett L, Corkey BE, Cashel JA, Zopf D. Partial structure of an insulin-sensitive glycophospholipid. Biochem Biophys Res Commun. 1987 Jul 31; 146(2):764-70. PMID: 3304285
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Kilpatrlck-Smith L, Douglas S, Polin RA, Corkey BE. EFFECTS OF SUBLETHAL DOSES OF ENDOTOXIN AND ASPIRIN (ASA) ON RAT HEPATIC ENERGY METABOLISM: AN ANIMAL MODEL OF REYE SYNDROME. Pediatric Research. 1987; 4(1). View Publication
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Corkey BE, Duszynski J, Rich TL, Matschinsky B, Williamson JR. Regulation of free and bound magnesium in rat hepatocytes and isolated mitochondria. J Biol Chem. 1986 Feb 25; 261(6):2567-74. PMID: 3081495
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Matschinsky FM, Meglasson M, Ghosh A, Appel M, Bedoya F, Prentki M, Corkey B, Shimizu T, Berner D, Najafi H, et al. Biochemical design features of the pancreatic islet cell glucose-sensory system. Adv Exp Med Biol. 1986; 211:459-69. PMID: 3300199
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Matschinsky, F.M., Meglasson, M., Ghosh, A., Appel, M., Bedoya, F., Prentki, M., Corkey, B. E., Shimizu, T., Berner, D., Najafi, H. and Manning, C. Biochemical design features of the pancreatic islet cell glucose-sensory system. Adv. Exp. Biol. Med. 1986; 211:459-469.
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Williamson, J.R., Corkey, B. E., Martin-Requero, A., Walajtys-Rode, E. and Coll, K.E. (. Metabolic repercussions of branched chain ketoacid metabolism in liver. Problems and Potential of Branched Chain Amino Acids in Physiology and Medicine (R. Odessey, ed.). Elsevier. North Holland, Amsterdam. 1986; pp. 135-172.
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Woldegiorgis G, Spennetta T, Corkey BE, Williamson JR, Shrago E. Extraction of tissue long-chain acyl-CoA esters and measurement by reverse-phase high-performance liquid chromatography. Anal Biochem. 1985 Oct; 150(1):8-12. PMID: 4083485
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Prentki M, Corkey BE, Matschinsky FM. Inositol 1,4,5-trisphosphate and the endoplasmic reticulum Ca2+ cycle of a rat insulinoma cell line. J Biol Chem. 1985 Aug 05; 260(16):9185-90. PMID: 2991236
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Coates PM, Hale DE, Stanley CA, Corkey BE, Cortner JA. Genetic deficiency of medium-chain acyl coenzyme A dehydrogenase: studies in cultured skin fibroblasts and peripheral mononuclear leukocytes. Pediatr Res. 1985 Jul; 19(7):671-6. PMID: 4022673; DOI: 10.1203/00006450-198507000-00007;
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Woldegiorgis G, Spennetta T, Corkey BE. Extraction of tissue long chain acyl CoAs and measurement by reverse phase HPLC. 1985.
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Prentki M, Corkey BE, Najafi H, Matschinsky FM. Ca2+ cycling across the endoplasmic reticulum (ER) of rat insulinoma RINm5F cells: Inositol 1,4,5-triphosphate (IP3) infusion studies. 1985.
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Joseph SK, Williams RJ, Corkey BE, Matschinsky FM, Williamson JR. The effect of inositol trisphosphate on Ca2+ fluxes in insulin-secreting tumor cells. J Biol Chem. 1984 Nov 10; 259(21):12952-5. PMID: 6092355
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Hale DE, Corkey BE, Stanley CA. EFFECTS OF VALPROIC ACID (DEPAKENE) ON KETOGENESIS (K), GLUCONEOGENESIS (G), AND UREAGENESIS (U) BY RAT HEPATOCYTES. Pediatric Research. 1984; 18. View Publication
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Williamson, J.R., Corkey, B. E., Martin-Requero, A., Walajtys-Rode, E. and Coll, K.E. a-Ketoisovalerate metabolism in liver and interactions with other metabolic pathways. Proceedings of International Symposium on Branched Chain Aminoacids and Ketoacids in Health and Disease. (P. Schauder, ed.). Karger, Basel. 1984; pp. 41-80.
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Stanley CA, Hale DE, Coates PM, Hall CL, Corkey BE, Yang W, Kelley RI, Gonzales EL, Williamson JR, Baker L. Medium-chain acyl-CoA dehydrogenase deficiency in children with non-ketotic hypoglycemia and low carnitine levels. Pediatr Res. 1983 Nov; 17(11):877-84. PMID: 6646897; DOI: 10.1203/00006450-198311000-00008;
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Martin-Requero A, Corkey BE, Cerdan S, Walajtys-Rode E, Parrilla RL, Williamson JR. Interactions between alpha-ketoisovalerate metabolism and the pathways of gluconeogenesis and urea synthesis in isolated hepatocytes. J Biol Chem. 1983 Mar 25; 258(6):3673-81. PMID: 6833225
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Kelley RI, Corkey BE. Increased sensitivity of cerebrohepatorenal syndrome fibroblasts to antimycin A. J Inherit Metab Dis. 1983; 6(4):158-62. PMID: 6321855
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Corkey BE, Martin-Requero A, Walajtys-Rode E, Williams RJ, Williamson JR. Regulation of the branched chain alpha-ketoacid pathway in liver. J Biol Chem. 1982 Aug 25; 257(16):9668-76. PMID: 6809741
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Coll KE, Joseph SK, Corkey BE, Williamson JR. Determination of the matrix free Ca2+ concentration and kinetics of Ca2+ efflux in liver and heart mitochondria. J Biol Chem. 1982 Aug 10; 257(15):8696-704. PMID: 6807979
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Corkey BE, Brandt M, Williams RJ, Williamson JR. Assay of short-chain acyl coenzyme A intermediates in tissue extracts by high-pressure liquid chromatography. Anal Biochem. 1981 Nov 15; 118(1):30-41. PMID: 6278980
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Corkey RF, Corkey BE, Gimbrone MA. Hexose transport in normal and SV40-transformed human endothelial cells in culture. J Cell Physiol. 1981 Mar; 106(3):425-34. PMID: 6260823; DOI: 10.1002/jcp.1041060312;
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Corkey BE, Martin-Requero A, Brandt M, Williamson JR. Elsevier. Regulation of a-ketoisocaproate and a-ketoisovalerate metabolism and their interactions with the citric acid cycle in isolated hepatocytes. 1981; 119-127.
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Williamson, J.R., Martin-Requero, A., Corkey, B. E., Brandt, M. and Rothman, R. Interactions between a-ketoisovalerate, propionate, and fatty acids on gluconeogenesis and ureogenesis in isolated hepatocytes. Metabolism and Clinical Implications of Branched Chain Amino and Ketoacids (Walser, M. and Williamson,J.R., Eds.). Elsevier. North Holland, New York. 1981; pp. 105-117.
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Corkey, B. E., Martin-Requero, A., Brandt, M. and Williamson, J.R. Regulation of a-ketoisocaproate and a-ketoisovalerate metabolism and their interactions with the citric acid cycle in isolated hepatocytes. Metabolism and Clinical Implications of Branched Chain Amino and Ketoacids (Walser,M. and Williamson, J.R., Eds.). Elsevier. North Holland, New York. 1981; pp. 119-127.
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Schwartz SS, Corkey B, Williamson JR, Rubenstein AH. Effect of bovine pancreatic polypeptide on isolated rat liver cells. Endocrinology. 1980 Apr; 106(4):1178-81. PMID: 7358031; DOI: 10.1210/endo-106-4-1178;
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Williamson JR, Corkey BE. Assay of citric acid cycle intermediates and related compounds--update with tissue metabolite levels and intracellular distribution. Methods Enzymol. 1979; 55:200-22. PMID: 459841
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Williamson, J.R. and Corkey, B. E. Assay of citric acid cycle intermediates and related compounds: Update with tissue metabolite levels and intracellular distribution. Methods Enzymol. 1979; 55:200-222.
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Page M, Morville M, Corkey BE. Fenfluramine-mediated improvements in glucose tolerance: comparison with phenformin. International Journal of Obesity. 1978; 2.
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Hoek JB, Corkey BE, Rich TL. Sulfonylurea-induced changes in calcium permeability of biological membranes. 1978.
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Corkey BE, Swindell AC, Pettini JL, Mayhew DA. The influence of thyroid hormone on glucose homeostasis in normal and genetically obese rodents. Abstr. 1977.
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Corkey BE, Peterson MJ, Pereira JN, Mayhew DA. Inhibition of hepatic fatty acid oxidation by 5-methoxyindole-2-carboxylic acid. Isr J Med Sci. 1972 Jun; 8(6):855-6. PMID: 5051821
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Williamson J, Corkey BE. Succinate determination with succinate thiokinase, pyruvate kinase and lactate dehydrogenase. Methods in Enzymology. 1969; 13:458-462.
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Williamson, J.R. and Corkey, B. E. Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods. Methods Enzymol. 1969; 13:434-513.
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Williamson JR, Cheung WY, Coles HS, Herczeg BE. Glycolytic control mechanisms. IV. Kinetics of glycolytic intermediate changes during electrical discharge and recovery in the main organ of Electrophorus electricus. J Biol Chem. 1967 Nov 10; 242(21):5112-8. PMID: 4228674
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Williamson JR, Herczeg BE, Coles HS, Cheung WY. Glycolytic control mechanisms. V. Kinetics of high energy phosphate intermediate changes during electrical discharge and recovery in the main organ of Electrophorus electricus. J Biol Chem. 1967 Nov 10; 242(21):5119-24. PMID: 4293783
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Williamson JR, Olson MS, Herczeg BE, Coles HS. Control of citrate formation in rat liver mitochondria. Biochem Biophys Res Commun. 1967 Jun 9; 27(5):595-600. PMID: 6033144
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Williamson JR, Herczeg B, Coles H, Danish R. Studies on the ketogenic effect of glucagon in intact rat liver. Biochem Biophys Res Commun. 1966 Aug 12; 24(3):437-42. PMID: 5967108
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Assimacopoulos-Jeannet F, Segall L, Roche E, Lemeloise N, Corkey BE, Prentki M. Altered lipid rather than glucose metabolism contributes to elevated basal insulin secretion in ß (INS) cells chronically exposed to fatty acids. Diabetologia.
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Fatherazi S, Cook DL, Tornheim K, Corkey BE. Physiological low levels of ADP reverse the inhibition of ATP-sensitive K-channels by ATP.
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Williamson JR, Martin-Requero A, Corkey BE, Brandt M, Rothman R. Regulation of a-ketoisovalerate, propionate, and fatty acids on gluconegenesis and ureogenesis in isolated hepatocytes.
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Guo W, Lei T, Wang T, Corkey BE, Han J. Biochemical and Molecular Actions of Nutrients.
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Williamson JR, Corkey BE. Methods in Enzymology.