Katya Ravid, DSc
Barbara E. Corkey Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine

PhD, Technion - Israel Institute of Technology
DSc, Technion - Israel Institute of Technology




Platelet activation plays a central role in thrombosis and hemostasis, while these processes are central to vascular health and disease. In the platelet lineage, bone marrow stem cells develop into early committed megakaryocyte progenitors, which undergo a unique cell cycle leading to polyploid cells prior to fragmenting into platelets. Our research focuses on mechanisms that regulate these processes under normal conditions vs. pathology. We proposed a new paradigm for controlling the transcription of genes uniquely expressed in this lineage, by identifying a cluster of non-tissue specific transcription factors that, together, constitute a signature uniquely driving this lineage development, among other cell lineages in the bone marrow. Studies were extended to identifying mechanisms governing polyploidy in megakaryocytes, leading also to better understanding of regulatory processes that cause polyploidy in other cells, such as aging vascular smooth muscle cells. Past projects involved molecular characterization of platelet and vascular adenosine receptors, and exploration of their roles in such cellular function. Importantly, knowledge gained by studying basic regulatory processes in healthy megakaryocytes and platelets aids our investigation of bone marrow pathologies, such as myeloproliferative neoplasms (MPNs). The systems used include primary bone marrow cultures, as well as transgenic and knock out mouse models.

Diversity, Equity, Inclusion and Accessibility

Commitment to inclusion, justice and excellence has been at the core of my professional and personal life. Diversity has been shown in various forums to contribute to creativity, mutual enrichment and collaborative building. Over the years, I have taken steps to contribute to enhanced diversity in our academic community in several ways, such as: 1. In the context of directly promoting interdisciplinary research related to health equity, I am currently (2022) the Director of a newly funded American Heart Association Center focused on the study of “Cancer-Associated Thromboembolism as Affected by Health Disparities (CAT-HD)”; 2. Affinity Research Collaborative groups within the Evans Center for Interdisciplinary Biomedical Research, which I direct, work on engaging patients and community members from underserved populations; 3. I participate as Subject Matter Expert on "Expanding Interdisciplinary Research" at the Northeast Faculty Leadership Program: Faculty Success through Diversity (NFLP), a leadership program for senior faculty of color funded by the Alfred P. Sloan Foundation, including tenured, underrepresented STEM faculty from ten area universities: Boston University, Harvard University, Northeastern University, Salem State University, Suffolk University, Tufts University, University of Connecticut, University of Massachusetts Boston, Wellesley College, and Wheaton College (Principal Investigator: Debra L. Franko, Ph.D., Northeastern University); 4. In my own laboratory, and through my leadership roles, I have served as a mentor to pre- and post-doctoral fellows and junior faculty of minority populations, who continue to propel the messages of research excellence and inclusion; 5. Within the Cardiovascular Biology NIH-funded training program that I directed for nearly 2 decades at BUSM, I made sure to provide opportunities to students of minority populations, with 20% of our trainees self-identifying as Hispanic or Black, and 50% as females; 6. As past member of admissions committees at BUSM, I participated in granting full attention to evaluating trainees from underserved communities; 7. The problems of inequity and bias can often be gender-based. Through my leadership roles, I have encouraged women researchers (trainees and faculty) to believe and achieve. Most of my past mentees are holding faculty and research leadership positions, nationwide and internationally.

Professor
Boston University School of Medicine
Biochemistry


Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Whitaker Cardiovascular Institute


Founding Director
Boston University
Evans Center for Interdisciplinary Biomedical Research


Director, Master of Science Program in Biomedical Research
Boston University School of Medicine
Medicine


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Megakaryocyte Mechanosensing Toward Platelet Biogenesis
09/01/2021 - 07/31/2025 (PI)
NIH/National Heart, Lung, and Blood Institute
1R01HL158670-01

Cancer-Associated Thromboembolism as Affected by Health Disparities (CAT-HD)
07/01/2021 - 06/30/2025 (PI)
American Heart Association


Lysyl Oxidase Pharmacological Inhibition of Bone Marow Fibrosis
03/01/2016 - 12/31/2022 (PI)
Pharmaxis


A path to thrombosis in primary myelofibrosis
12/24/2017 - 11/30/2022 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL136363-04

Training Program in Cardiovascular Biology: Pre-Doctoral
12/01/2014 - 11/30/2020 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL007969-15

Mechanism of Bone Marrow Neoplasm-Induced Osteosclerosis
05/01/2018 - 04/30/2020 (Multi-PI)
PI: Katya Ravid, DSc
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R21AR072748-02

Mechanisms of Control of Lysyl Oxidase Expression in JAK2-Mutated Myelofibrotic Cells
07/01/2017 - 06/30/2018 (Key Person / Mentor)
American Society of Hematology


Mechanisms Regulating Megakaryocyte Development
04/01/2012 - 09/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL080442-09

The role of lysysl oxidase in facilitating JAK2V617F mutation-induced myelofibrosis
07/01/2016 - 06/30/2017 (Key Person / Mentor)
American Society of Hematology


Nanoplatforms for Imaging Bone Marrow Fibrosis
10/01/2014 - 09/30/2016 (PI)
MPN Research Foundation


Showing 10 of 18 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2022 Megakaryocyte Mechanosensing Toward Platelet Biogenesis 5R01HL158670-02
2021 Megakaryocyte Mechanosensing Toward Platelet Biogenesis 1R01HL158670-01
2021 A path to thrombosis in primary myelofibrosis 5R01HL136363-04 5
2020 A path to thrombosis in primary myelofibrosis 5R01HL136363-03 5
2019 Mechanism of Bone Marrow Neoplasm-Induced Osteosclerosis 5R21AR072748-02 1
2019 A path to thrombosis in primary myelofibrosis 5R01HL136363-02 5
2019 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-15 76
2018 Mechanism of Bone Marrow Neoplasm-Induced Osteosclerosis 1R21AR072748-01 1
2018 A path to thrombosis in primary myelofibrosis 1R01HL136363-01A1 5
2018 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-14 76
Showing 10 of 61 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Karagianni A, Matsuura S, Gerstenfeld LC, Ravid K. Inhibition of Osteoblast Differentiation by JAK2V617F Megakaryocytes Derived From Male Mice With Primary Myelofibrosis. Front Oncol. 2022; 12:929498.View Related Profiles. PMID: 35880162; PMCID: PMC9307716; DOI: 10.3389/fonc.2022.929498;
     
  2. Leiva O, Hobbs G, Ravid K, Libby P. Cardiovascular Disease in Myeloproliferative Neoplasms: JACC: CardioOncology State-of-the-Art Review. JACC CardioOncol. 2022 Jun; 4(2):166-182. PMID: 35818539; PMCID: PMC9270630; DOI: 10.1016/j.jaccao.2022.04.002;
     
  3. Karagianni A, Ravid K. Myeloproliferative disorders and their effects on bone homeostasis: the role of megakaryocytes. Blood. 2022 May 26; 139(21):3127-3137. PMID: 34428274; PMCID: PMC9136883; DOI: 10.1182/blood.2021011480;
     
  4. Gaye MM, Ward CM, Piasecki AJ, Stahl VL, Karagianni A, Costello CE, Ravid K. Characterization of Glycoproteoforms of Integrins a2 and ß1 in Megakaryocytes in the Occurrence of JAK2V617F Mutation-Induced Primary Myelofibrosis. Mol Cell Proteomics. 2022 Apr; 21(4):100213.View Related Profiles. PMID: 35182768; PMCID: PMC8968581; DOI: 10.1016/j.mcpro.2022.100213;
     
  5. Yang X, Chitalia SV, Matsuura S, Ravid K. Integrins and their role in megakaryocyte development and function. Exp Hematol. 2022 02; 106:31-39.View Related Profiles. PMID: 34910941; PMCID: PMC8795491; DOI: 10.1016/j.exphem.2021.11.007;
     
  6. Walker JA, Richards S, Whelan SA, Yoo SB, Russell TL, Arinze N, Lotfollahzadeh S, Napoleon MA, Belghasem M, Lee N, Dember LM, Ravid K, Chitalia VC. Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD. J Am Soc Nephrol. 2021 11; 32(11):2834-2850.View Related Profiles. PMID: 34716244; PMCID: PMC8806102; DOI: 10.1681/ASN.2020091310;
     
  7. Piasecki A, Leiva O, Ravid K. Lysyl oxidase inhibition in primary myelofibrosis: A renewed strategy. Arch Stem Cell Ther. 2020 Dec; 1(1):23-27. PMID: 33738462; PMCID: PMC7968867; DOI: 10.46439/stemcell.1.005;
     
  8. Eisenstein A, Chitalia SV, Ravid K. Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis. Int J Mol Sci. 2020 Oct 10; 21(20). PMID: 33050467; PMCID: PMC7589187; DOI: 10.3390/ijms21207470;
     
  9. Matsuura S, Thompson CR, Belghasem ME, Bekendam RH, Piasecki A, Leiva O, Ray A, Italiano J, Yang M, Merill-Skoloff G, Chitalia VC, Flaumenhaft R, Ravid K. Platelet Dysfunction and Thrombosis in JAK2V617F-Mutated Primary Myelofibrotic Mice. Arterioscler Thromb Vasc Biol. 2020 10; 40(10):e262-e272.View Related Profiles. PMID: 32814440; PMCID: PMC7605151; DOI: 10.1161/ATVBAHA.120.314760;
     
  10. Matsuura S, Thompson CR, Ng SK, Ward CM, Karagianni A, Mazzeo C, Malara A, Balduini A, Ravid K. Adhesion to fibronectin via a5ß1 integrin supports expansion of the megakaryocyte lineage in primary myelofibrosis. Blood. 2020 06 18; 135(25):2286-2291.View Related Profiles. PMID: 32294178; PMCID: PMC7316217; DOI: 10.1182/blood.2019004230;
     
Showing 10 of 164 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 164 publications over 38 distinct years, with a maximum of 13 publications in 2008

YearPublications
19802
19831
19841
19851
19881
19891
19912
19921
19932
19941
19953
19964
19973
19982
19997
20003
20013
20028
20033
20045
20054
20064
20072
200813
20099
20107
20117
201210
201310
20147
20154
20164
20178
20185
20195
20205
20212
20224


Why Are Black Cancer Patients at Higher Risk for Blood Clots?

The Brink 9/13/2021

Katya Ravid Named Inaugural Incumbent Barbara E. Corkey Professor of Medicine

Boston University School of Medicine Website 4/11/2021

Pharmaxis discoveries showing promise in bone marrow cancer, according to Boston University School of Medicine publication

Proactive 3/24/2021

2018-now Massachusetts Academy of Sciences : President
2016 Fulbright : Fulbright Research Scholar Award
2016-2017 Aarhus University, Denmark : International Advisory Board
2014 Weizmann Institute: Weizmann Institute Professorship Award
2014 American Association for the Advancement of Science: Elected Fellow
2013 Boston University School of Medicine: Robert Dawson Evans Special Recognition Teaching Award
2013-2016 American Society of Hematology: Chair, Thrombosis and Vascular Biology Scientific Committee
2011-2013 Gordon Research Conference-Cell Biology of Megakaryocytes and Platelets: Vice Chair & Chair
2009 University of Sydney : International Visiting Professor Fellowship Award
2006 Boston University School of Medicine : Educator of the Year Award, Graduate Medical Sciences
2000-2005 American Heart Association: Established Investigator Award
1997 American Heart Association: Grant-In-Aid Award for Young Investigators
1987 Weizmann Institute: Weizmann Postdoctoral Fellowship Award
1982 Technion: Gutwirth Prize for Outstanding Graduate Students
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Adenosine Receptors
Blood Cells
Cell Cycle Control
Hematopoietic Stem Cells
Megakaryocyte
Platelet
Polyploidy
Vascular Biology

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Boston MA 02118
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