Katya Ravid, DSc

Platelet activation plays a central role in thrombosis and hemostasis, while these processes are central to vascular health and disease. In the platelet lineage, bone marrow stem cells develop into early committed megakaryocyte progenitors, which undergo a unique cell cycle leading to polyploid cells prior to fragmenting into platelets. Our research focuses on mechanisms that regulate these processes under normal conditions vs. pathology. We proposed a new paradigm for controlling the transcription of genes uniquely expressed in this lineage, by identifying a cluster of non-tissue specific transcription factors that, together, constitute a signature uniquely driving this lineage development, among other cell lineages in the bone marrow. Studies were extended to identifying mechanisms governing polyploidy in megakaryocytes, leading also to better understanding of regulatory processes that cause polyploidy in other cells, such as aging vascular smooth muscle cells. Past projects involved molecular characterization of platelet and vascular adenosine receptors, and exploration of their roles in such cellular function. Importantly, knowledge gained by studying basic regulatory processes in healthy megakaryocytes and platelets aids our investigation of bone marrow pathologies, such as myeloproliferative neoplasms (MPNs). The systems used include primary bone marrow cultures, as well as transgenic and knock out mouse models.

Boston University School of Medicine

Boston University
BU-BMC Cancer Center

Boston University
Whitaker Cardiovascular Institute

Founding Director
Boston University
Evans Center for Interdisciplinary Biomedical Research

Director, Master of Science Program in Biomedical Research
Boston University School of Medicine

Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

2018-now Massachusetts Academy of Sciences : President
2016 Fulbright : Fulbright Research Scholar Award
2016-2017 Aarhus University, Denmark : International Advisory Board
2014 Weizmann Institute: Weizmann Institute Professorship Award
2014 American Association for the Advancement of Science: Elected Fellow
2013 Boston University School of Medicine: Robert Dawson Evans Special Recognition Teaching Award
2013-2016 American Society of Hematology: Chair, Thrombosis and Vascular Biology Scientific Committee
2011-2013 Gordon Research Conference-Cell Biology of Megakaryocytes and Platelets: Vice Chair & Chair
2009 University of Sydney : International Visiting Professor Fellowship Award
2006 Boston University School of Medicine : Educator of the Year Award, Graduate Medical Sciences
2000-2005 American Heart Association: Established Investigator Award
1997 American Heart Association: Grant-In-Aid Award for Young Investigators
1987 Weizmann Institute: Weizmann Postdoctoral Fellowship Award
1982 Technion: Gutwirth Prize for Outstanding Graduate Students

Megakaryocyte Mechanosensing Toward Platelet Biogenesis
09/01/2021 - 07/31/2025 (PI)
NIH/National Heart, Lung, and Blood Institute

Cancer-Associated Thromboembolism as Affected by Health Disparities (CAT-HD)
07/01/2021 - 06/30/2025 (PI)
American Heart Association

Lysyl Oxidase Pharmacological Inhibition of Bone Marow Fibrosis
03/01/2016 - 12/31/2022 (PI)

A path to thrombosis in primary myelofibrosis
12/24/2017 - 11/30/2022 (PI)
NIH/National Heart, Lung, and Blood Institute

Training Program in Cardiovascular Biology: Pre-Doctoral
12/01/2014 - 11/30/2020 (PI)
NIH/National Heart, Lung, and Blood Institute

Mechanism of Bone Marrow Neoplasm-Induced Osteosclerosis
05/01/2018 - 04/30/2020 (Multi-PI)
PI: Katya Ravid, DSc
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases

Mechanisms Regulating Megakaryocyte Development
04/01/2012 - 09/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute

Nanoplatforms for Imaging Bone Marrow Fibrosis
10/01/2014 - 09/30/2016 (PI)
MPN Research Foundation

Mechanisms Regulating Megakaryocte Development
04/01/2012 - 03/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute

Training in Cardiovascular Biology: Predoctoral
07/01/2001 - 11/30/2014 (PI)
NIH/National Heart, Lung, and Blood Institute

Showing 10 of 16 results. Show All Results


Yr Title Project-Sub Proj Pubs
2021 Megakaryocyte Mechanosensing Toward Platelet Biogenesis 1R01HL158670-01
2021 A path to thrombosis in primary myelofibrosis 5R01HL136363-04 5
2020 A path to thrombosis in primary myelofibrosis 5R01HL136363-03 5
2019 Mechanism of Bone Marrow Neoplasm-Induced Osteosclerosis 5R21AR072748-02 1
2019 A path to thrombosis in primary myelofibrosis 5R01HL136363-02 5
2019 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-15 76
2018 Mechanism of Bone Marrow Neoplasm-Induced Osteosclerosis 1R21AR072748-01 1
2018 A path to thrombosis in primary myelofibrosis 1R01HL136363-01A1 5
2018 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-14 76
2017 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-13 76
Showing 10 of 60 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Walker JA, Richards S, Whelan SA, Yoo SB, Russell TL, Arinze N, Lotfollahzadeh S, Napoleon MA, Belghasem M, Lee N, Dember LM, Ravid K, Chitalia VC. Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD. J Am Soc Nephrol. 2021 Nov; 32(11):2834-2850.View Related Profiles. PMID: 34716244
  2. Ravid K, Karagianni A. Myeloproliferative Disorders and its Effect on Bone Homeostasis: The Role of Megakaryocytes. Blood. 2021 Aug 24. PMID: 34428274
  3. Piasecki A, Leiva O, Ravid K. Lysyl oxidase inhibition in primary myelofibrosis: A renewed strategy. Arch Stem Cell Ther. 2020 Dec; 1(1):23-27. PMID: 33738462; PMCID: PMC7968867; DOI: 10.46439/stemcell.1.005;
  4. Eisenstein A, Chitalia SV, Ravid K. Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis. Int J Mol Sci. 2020 Oct 10; 21(20). PMID: 33050467; PMCID: PMC7589187; DOI: 10.3390/ijms21207470;
  5. Matsuura S, Thompson CR, Belghasem ME, Bekendam RH, Piasecki A, Leiva O, Ray A, Italiano J, Yang M, Merill-Skoloff G, Chitalia VC, Flaumenhaft R, Ravid K. Platelet Dysfunction and Thrombosis in JAK2V617F-Mutated Primary Myelofibrotic Mice. Arterioscler Thromb Vasc Biol. 2020 10; 40(10):e262-e272.View Related Profiles. PMID: 32814440; PMCID: PMC7605151; DOI: 10.1161/ATVBAHA.120.314760;
  6. Matsuura S, Thompson CR, Ng SK, Ward CM, Karagianni A, Mazzeo C, Malara A, Balduini A, Ravid K. Adhesion to fibronectin via a5ß1 integrin supports expansion of the megakaryocyte lineage in primary myelofibrosis. Blood. 2020 06 18; 135(25):2286-2291.View Related Profiles. PMID: 32294178; PMCID: PMC7316217; DOI: 10.1182/blood.2019004230;
  7. Ward CM, Ravid K. Matrix Mechanosensation in the Erythroid and Megakaryocytic Lineages. Cells. 2020 04 06; 9(4).View Related Profiles. PMID: 32268541; PMCID: PMC7226728; DOI: 10.3390/cells9040894;
  8. Belghasem M, Roth D, Richards S, Napolene MA, Walker J, Yin W, Arinze N, Lyle C, Spencer C, Francis JM, Thompson C, Andry C, Whelan SA, Lee N, Ravid K, Chitalia VC. Metabolites in a mouse cancer model enhance venous thrombogenicity through the aryl hydrocarbon receptor-tissue factor axis. Blood. 2019 12 26; 134(26):2399-2413.View Related Profiles. PMID: 31877217; PMCID: PMC6933294; DOI: 10.1182/blood.2019001675;
  9. Walker JA, Richards S, Belghasem ME, Arinze N, Yoo SB, Tashjian JY, Whelan SA, Lee N, Kolachalama VB, Francis J, Ravid K, Sherr D, Chitalia VC. Temporal and tissue-specific activation of aryl hydrocarbon receptor in discrete mouse models of kidney disease. Kidney Int. 2020 03; 97(3):538-550.View Related Profiles. PMID: 31932072
  10. Leiva O, Ng SK, Matsuura S, Chitalia V, Lucero H, Findlay A, Turner C, Jarolimek W, Ravid K. Novel lysyl oxidase inhibitors attenuate hallmarks of primary myelofibrosis in mice. Int J Hematol. 2019 Dec; 110(6):699-708.View Related Profiles. PMID: 31637674; PMCID: PMC7503219; DOI: 10.1007/s12185-019-02751-6;
Showing 10 of 160 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 160 publications over 37 distinct years, with a maximum of 13 publications in 2008

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Adenosine Receptors
Blood Cells
Cell Cycle Control
Hematopoietic Stem Cells
Vascular Biology

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