Katya Ravid, DSc

Platelet activation plays a central role in thrombosis and hemostasis, while these processes are central to vascular health and disease. In the platelet lineage, bone marrow stem cells develop into early committed megakaryocyte progenitors, which undergo a unique cell cycle leading to polyploid cells prior to fragmenting into platelets. Our research focuses on mechanisms that regulate these processes under normal conditions vs. pathology. We proposed a new paradigm for controlling the transcription of genes uniquely expressed in this lineage, by identifying a cluster of non-tissue specific transcription factors that, together, constitute a signature uniquely driving this lineage development, among other cell lineages in the bone marrow. Studies were extended to identifying mechanisms governing polyploidy in megakaryocytes, leading also to better understanding of regulatory processes that cause polyploidy in other cells, such as aging vascular smooth muscle cells. Past projects involved molecular characterization of platelet and vascular adenosine receptors, and exploration of their roles in such cellular function. Importantly, knowledge gained by studying basic regulatory processes in healthy megakaryocytes and platelets aids our investigation of bone marrow pathologies, such as myeloproliferative neoplasms (MPNs). The systems used include primary bone marrow cultures, as well as transgenic and knock out mouse models.

Diversity, Equity, Inclusion and Accessibility

Commitment to inclusion, justice and excellence has been at the core of my professional and personal life. Diversity has been shown in various forums to contribute to creativity, mutual enrichment and collaborative building. Over the years, I have taken steps to contribute to enhanced diversity in our academic community in several ways, such as: 1. In the context of directly promoting interdisciplinary research related to health equity, I am currently (2022) the Director of a newly funded American Heart Association Center focused on the study of “Cancer-Associated Thromboembolism as Affected by Health Disparities (CAT-HD)”; 2. Affinity Research Collaborative groups within the Evans Center for Interdisciplinary Biomedical Research, which I direct, work on engaging patients and community members from underserved populations; 3. I participate as Subject Matter Expert on "Expanding Interdisciplinary Research" at the Northeast Faculty Leadership Program: Faculty Success through Diversity (NFLP), a leadership program for senior faculty of color funded by the Alfred P. Sloan Foundation, including tenured, underrepresented STEM faculty from ten area universities: Boston University, Harvard University, Northeastern University, Salem State University, Suffolk University, Tufts University, University of Connecticut, University of Massachusetts Boston, Wellesley College, and Wheaton College (Principal Investigator: Debra L. Franko, Ph.D., Northeastern University); 4. In my own laboratory, and through my leadership roles, I have served as a mentor to pre- and post-doctoral fellows and junior faculty of minority populations, who continue to propel the messages of research excellence and inclusion; 5. Within the Cardiovascular Biology NIH-funded training program that I directed for nearly 2 decades at BUSM, I made sure to provide opportunities to students of minority populations, with 20% of our trainees self-identifying as Hispanic or Black, and 50% as females; 6. As past member of admissions committees at BUSM, I participated in granting full attention to evaluating trainees from underserved communities; 7. The problems of inequity and bias can often be gender-based. Through my leadership roles, I have encouraged women researchers (trainees and faculty) to believe and achieve. Most of my past mentees are holding faculty and research leadership positions, nationwide and internationally.

Professor
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology


Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Whitaker Cardiovascular Institute


Founding Director
Boston University
Evans Center for Interdisciplinary Biomedical Research


Director, Master of Science Program in Biomedical Research
Boston University Chobanian & Avedisian School of Medicine
Medicine


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Disease-specific risk factors for thrombosis following vascular interventions
08/01/2023 - 07/31/2027 (Subcontract PI)
Boston Medical Center Corporation NIH NHLBI
1R01HL166608-01A1

Lysyl Oxidase Pharmacological Inhibition of Bone Marow Fibrosis
03/01/2016 - 12/31/2025 (PI)
Pharmaxis


Allostatic Load and Cardio-Oncology Disparities
10/01/2022 - 09/30/2025 (PI)
American Heart Association


Megakaryocyte Mechanosensing Toward Platelet Biogenesis
09/01/2021 - 07/31/2025 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL158670-03

Cancer-Associated Thromboembolism as Affected by Health Disparities (CAT-HD)
07/01/2021 - 06/30/2025 (PI)
American Heart Association


A path to thrombosis in primary myelofibrosis
12/24/2017 - 11/30/2022 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL136363-04

Training Program in Cardiovascular Biology: Pre-Doctoral
12/01/2014 - 11/30/2020 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL007969-15

Mechanism of Bone Marrow Neoplasm-Induced Osteosclerosis
05/01/2018 - 04/30/2020 (Multi-PI)
PI: Katya Ravid, DSc
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R21AR072748-02

Mechanisms of Control of Lysyl Oxidase Expression in JAK2-Mutated Myelofibrotic Cells
07/01/2017 - 06/30/2018 (Key Person / Mentor)
American Society of Hematology


Mechanisms Regulating Megakaryocyte Development
04/01/2012 - 09/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL080442-09

Showing 10 of 20 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2023 Disease-specific risk factors for thrombosis following vascular interventions 1R01HL166608-01A1
2023 Megakaryocyte Mechanosensing Toward Platelet Biogenesis 5R01HL158670-03
2022 Megakaryocyte Mechanosensing Toward Platelet Biogenesis 5R01HL158670-02
2021 Megakaryocyte Mechanosensing Toward Platelet Biogenesis 1R01HL158670-01
2021 A path to thrombosis in primary myelofibrosis 5R01HL136363-04 5
2020 A path to thrombosis in primary myelofibrosis 5R01HL136363-03 5
2019 Mechanism of Bone Marrow Neoplasm-Induced Osteosclerosis 5R21AR072748-02 1
2019 A path to thrombosis in primary myelofibrosis 5R01HL136363-02 5
2019 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-15 76
2018 Mechanism of Bone Marrow Neoplasm-Induced Osteosclerosis 1R21AR072748-01 1
Showing 10 of 63 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Karagianni A, Karkempetzaki AI, Brooks D, Matsuura S, Dambal V, Trackman PC, Ravid K. Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner. Blood. 2024 Jun 20; 143(25):2666-2670.View Related Profiles. PMID: 38635757; PMCID: PMC11196861; DOI: 10.1182/blood.2024024620;
     
  2. Ma S, La J, Swinnerton KN, Guffey D, Bandyo R, De Las Pozas G, Hanzelka K, Xiao X, Rojas-Hernandez CM, Amos CI, Chitalia V, Ravid K, Merriman KW, Flowers CR, Fillmore N, Li A. Thrombosis risk prediction in lymphoma patients: A multi-institutional, retrospective model development and validation study. Am J Hematol. 2024 Jul; 99(7):1230-1239.View Related Profiles. PMID: 38654461; PMCID: PMC11166507; DOI: 10.1002/ajh.27335;
     
  3. Karkempetzaki AI, Ravid K. Piezo1 and Its Function in Different Blood Cell Lineages. Cells. 2024 Mar 09; 13(6). PMID: 38534326; PMCID: PMC10969519; DOI: 10.3390/cells13060482;
     
  4. Lotfollahzadeh S, Yang X, Wu Wong DJ, Han J, Seta F, Ganguli S, Jose A, Ravid K, Chitalia VC. Venous Thrombosis Assay in a Mouse Model of Cancer. J Vis Exp. 2024 Jan 05; (203).View Related Profiles. PMID: 38251710
     
  5. Abbonante V, Karkempetzaki AI, Leon C, Krishnan A, Huang N, Di Buduo CA, Cattaneo D, Ward CM, Matsuura S, Guinard I, Weber J, De Acutis A, Vozzi G, Iurlo A, Ravid K, Balduini A. Newly identified roles for PIEZO1 mechanosensor in controlling normal megakaryocyte development and in primary myelofibrosis. Am J Hematol. 2024 Mar; 99(3):336-349.View Related Profiles. PMID: 38165047; PMCID: PMC10922533; DOI: 10.1002/ajh.27184;
     
  6. Bekendam RH, Ravid K. Mechanisms of platelet activation in cancer-associated thrombosis: a focus on myeloproliferative neoplasms. Front Cell Dev Biol. 2023; 11:1207395. PMID: 37457287; PMCID: PMC10342211; DOI: 10.3389/fcell.2023.1207395;
     
  7. Martens KL, Li A, La J, May SB, Swinnerton KN, Tosi H, Elbers DC, Do NV, Brophy MT, Gaziano JM, Lotfollahzadeh S, Chitalia V, Ravid K, Fillmore NR. Epidemiology of Cancer-Associated Venous Thromboembolism in Patients With Solid and Hematologic Neoplasms in the Veterans Affairs Health Care System. JAMA Netw Open. 2023 Jun 01; 6(6):e2317945.View Related Profiles. PMID: 37306999; PMCID: PMC10261992; DOI: 10.1001/jamanetworkopen.2023.17945;
     
  8. Li A, May SB, La J, Martens KL, Amos CI, Flowers CR, Do NV, Brophy MT, Chitalia V, Ravid K, Gaziano JM, Fillmore NR. Venous thromboembolism risk in cancer patients receiving first-line immune checkpoint inhibitor versus chemotherapy. Am J Hematol. 2023 Aug; 98(8):1214-1222.View Related Profiles. PMID: 37161855; PMCID: PMC10569448; DOI: 10.1002/ajh.26954;
     
  9. Karagianni A, Matsuura S, Gerstenfeld LC, Ravid K. Inhibition of Osteoblast Differentiation by JAK2V617F Megakaryocytes Derived From Male Mice With Primary Myelofibrosis. Front Oncol. 2022; 12:929498.View Related Profiles. PMID: 35880162; PMCID: PMC9307716; DOI: 10.3389/fonc.2022.929498;
     
  10. Leiva O, Hobbs G, Ravid K, Libby P. Cardiovascular Disease in Myeloproliferative Neoplasms: JACC: CardioOncology State-of-the-Art Review. JACC CardioOncol. 2022 Jun; 4(2):166-182. PMID: 35818539; PMCID: PMC9270630; DOI: 10.1016/j.jaccao.2022.04.002;
     
Showing 10 of 172 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 172 publications over 40 distinct years, with a maximum of 13 publications in 2008

YearPublications
19802
19831
19841
19851
19881
19891
19912
19921
19932
19941
19953
19964
19973
19982
19997
20003
20013
20028
20033
20045
20054
20064
20072
200813
20099
20107
20117
201210
201310
20147
20154
20164
20178
20185
20195
20205
20212
20224
20233
20245

2021 Boston University School of Medicine: Barbara E. Corkey Endowed Professorship of Medicine
2020 Boston University School of Medicine: Robert Dawson Evans Research Mentoring Award
2018-2022 Massachusetts Academy of Sciences : President
2016 Fulbright : Fulbright Research Scholar Award
2016-2017 Aarhus University, Denmark : International Advisory Board
2014 Weizmann Institute: Weizmann Institute Professorship Award
2014 American Association for the Advancement of Science: Elected Fellow
2013 Boston University School of Medicine: Robert Dawson Evans Special Recognition Teaching Award
2013-2016 American Society of Hematology: Chair, Thrombosis and Vascular Biology Scientific Committee
2011-2013 Gordon Research Conference-Cell Biology of Megakaryocytes and Platelets: Vice Chair & Chair
2009 University of Sydney : International Visiting Professor Fellowship Award
2006 Boston University School of Medicine : Educator of the Year Award, Graduate Medical Sciences
2000-2005 American Heart Association: Established Investigator Award
1997 American Heart Association: Grant-In-Aid Award for Young Investigators
1987 Weizmann Institute: Weizmann Postdoctoral Fellowship Award
1982 Technion: Gutwirth Prize for Outstanding Graduate Students
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Adenosine Receptors
Blood Cells
Cell Cycle Control
Hematopoietic Stem Cells
Megakaryocyte
Platelet
Polyploidy
Vascular Biology

Our mission as researchers is not complete, if at all achievable, without enhancing the research experiences of trainees and faculty, and cultivating the next generation of accomplished scientists, regardless of age, gender and race. KR

Available to Mentor as: (Review Mentor Role Definitions):
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  • Co-Mentor or Peer Mentor
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Contact for Mentoring:
  • Email (see 'Contact Info')

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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