Katya Ravid, DSc

Platelet activation plays a central role in thrombosis and hemostasis, while these processes are central to vascular health and disease. In the platelet lineage, bone marrow stem cells develop into early committed megakaryocyte progenitors, which undergo a unique cell cycle leading to polyploid cells prior to fragmenting into platelets. Our research focuses on mechanisms that regulate these processes under normal conditions vs. pathology. We proposed a new paradigm for controlling the transcription of genes uniquely expressed in this lineage, by identifying a cluster of non-tissue specific transcription factors that, together, constitute a signature uniquely driving this lineage development, among other cell lineages in the bone marrow. Studies were extended to identifying mechanisms governing polyploidy in megakaryocytes, leading also to better understanding of regulatory processes that cause polyploidy in other cells, such as aging vascular smooth muscle cells. Past projects involved molecular characterization of platelet and vascular adenosine receptors, and exploration of their roles in such cellular function. Importantly, knowledge gained by studying basic regulatory processes in healthy megakaryocytes and platelets aids our investigation of bone marrow pathologies, such as myeloproliferative neoplasms (MPNs). The systems used include primary bone marrow cultures, as well as transgenic and knock out mouse models.

Professor
Boston University School of Medicine
Biochemistry


Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Whitaker Cardiovascular Institute


Founding Director
Boston University
Evans Center for Interdisciplinary Biomedical Research


Director, Master of Science Program in Biomedical Research
Boston University School of Medicine
Medicine


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2018-now Massachusetts Academy of Sciences : President
2016 Fulbright : Fulbright Research Scholar Award
2016-2017 Aarhus University, Denmark : International Advisory Board
2014 Weizmann Institute: Weizmann Institute Professorship Award
2014 American Association for the Advancement of Science: Elected Fellow
2013 Boston University School of Medicine: Robert Dawson Evans Special Recognition Teaching Award
2013-2016 American Society of Hematology: Chair, Thrombosis and Vascular Biology Scientific Committee
2011-2013 Gordon Research Conference-Cell Biology of Megakaryocytes and Platelets: Vice Chair & Chair
2009 University of Sydney : International Visiting Professor Fellowship Award
2006 Boston University School of Medicine : Educator of the Year Award, Graduate Medical Sciences
2000-2005 American Heart Association: Established Investigator Award
1997 American Heart Association: Grant-In-Aid Award for Young Investigators
1987 Weizmann Institute: Weizmann Postdoctoral Fellowship Award
1982 Technion: Gutwirth Prize for Outstanding Graduate Students


A path to thrombosis in primary myelofibrosis
12/24/2017 - 11/30/2021 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL136363-03

Training Program in Cardiovascular Biology: Pre-Doctoral
12/01/2014 - 11/30/2020 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL007969-15

Lysyl Oxidase Pharmacological Inhibition of Bone Marow Fibrosis
03/01/2016 - 10/31/2020 (PI)
Pharmaxis


Mechanism of Bone Marrow Neoplasm-Induced Osteosclerosis
05/01/2018 - 04/30/2020 (Multi-PI)
PI: Katya Ravid, DSc
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R21AR072748-02

Mechanisms Regulating Megakaryocyte Development
04/01/2012 - 09/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL080442-09

Nanoplatforms for Imaging Bone Marrow Fibrosis
10/01/2014 - 09/30/2016 (PI)
MPN Research Foundation


Mechanisms Regulating Megakaryocte Development
04/01/2012 - 03/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
2R01HL080442-06A1

Training in Cardiovascular Biology: PREDOCTORAL
07/01/2001 - 11/30/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL007969-10

Training in Cardiovascular Biology: Predoctoral
07/01/2011 - 06/30/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL007969-09

Adenosine Receptors and Atherogenesis
04/01/2009 - 03/31/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL093149-04

Showing 10 of 14 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2020 A path to thrombosis in primary myelofibrosis 5R01HL136363-03 5
2019 Mechanism of Bone Marrow Neoplasm-Induced Osteosclerosis 5R21AR072748-02 1
2019 A path to thrombosis in primary myelofibrosis 5R01HL136363-02 5
2019 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-15 76
2018 Mechanism of Bone Marrow Neoplasm-Induced Osteosclerosis 1R21AR072748-01 1
2018 A path to thrombosis in primary myelofibrosis 1R01HL136363-01A1 5
2018 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-14 76
2017 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-13 76
2016 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-12 76
2015 Mechanisms Regulating Megakaryocyte Development 5R01HL080442-09 25
Showing 10 of 58 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Matsuura S, Thompson CR, Ng SK, Ward CM, Karagianni A, Mazzeo C, Malara A, Balduini A, Ravid K. Adhesion to fibronectin via a5ß1 integrin supports expansion of the megakaryocyte lineage in primary myelofibrosis. Blood. 2020 Jun 18; 135(25):2286-2291.View Related Profiles. PMID: 32294178
     
  2. Ward CM, Ravid K. Matrix Mechanosensation in the Erythroid and Megakaryocytic Lineages. Cells. 2020 Apr 06; 9(4).View Related Profiles. PMID: 32268541
     
  3. Belghasem M, Roth D, Richards S, Napolene MA, Walker J, Yin W, Arinze N, Lyle C, Spencer C, Francis JM, Thompson C, Andry C, Whelan SA, Lee N, Ravid K, Chitalia VC. Metabolites in a mouse cancer model enhance venous thrombogenicity through the aryl hydrocarbon receptor-tissue factor axis. Blood. 2019 12 26; 134(26):2399-2413.View Related Profiles. PMID: 31877217
     
  4. Walker JA, Richards S, Belghasem ME, Arinze N, Yoo SB, Tashjian JY, Whelan SA, Lee N, Kolachalama VB, Francis J, Ravid K, Sherr D, Chitalia VC. Temporal and tissue-specific activation of aryl hydrocarbon receptor in discrete mouse models of kidney disease. Kidney Int. 2020 Mar; 97(3):538-550.View Related Profiles. PMID: 31932072
     
  5. Leiva O, Ng SK, Matsuura S, Chitalia V, Lucero H, Findlay A, Turner C, Jarolimek W, Ravid K. Novel lysyl oxidase inhibitors attenuate hallmarks of primary myelofibrosis in mice. Int J Hematol. 2019 Dec; 110(6):699-708.View Related Profiles. PMID: 31637674
     
  6. Sano S, Wang Y, Yura Y, Sano M, Oshima K, Yang Y, Katanasaka Y, Min KD, Matsuura S, Ravid K, Mohi G, Walsh K. JAK2V617F -Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure. JACC Basic Transl Sci. 2019 Oct; 4(6):684-697.View Related Profiles. PMID: 31709318; DOI: 10.1016/j.jacbts.2019.05.013;
     
  7. Leiva O, Bekendam RH, Garcia BD, Thompson C, Cantor A, Chitalia V, Ravid K. Emerging Factors Implicated in Fibrotic Organ-Associated Thrombosis: The Case of Two Organs. TH Open. 2019 Apr; 3(2):e165-e170.View Related Profiles. PMID: 31259299
     
  8. Li HM, Jang JH, Jung JS, Shin J, Park CO, Kim YJ, Ahn WG, Nam JS, Hong CW, Lee J, Jung YJ, Chen JF, Ravid K, Lee HT, Huh WK, Kabarowski JH, Song DK. G2A Protects Mice against Sepsis by Modulating Kupffer Cell Activation: Cooperativity with Adenosine Receptor 2b. J Immunol. 2019 01 15; 202(2):527-538. PMID: 30530591
     
  9. Artuz CM, Knights AJ, Funnell APW, Gonda TJ, Ravid K, Pearson RCM, Quinlan KGR, Crossley M. Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules. Biotechnol Rep (Amst). 2018 Dec; 20:e00285. PMID: 30364711
     
  10. Koupenova M, Ravid K. Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity. Front Pharmacol. 2018; 9:37.View Related Profiles. PMID: 29441021
     
Showing 10 of 155 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 155 publications over 36 distinct years, with a maximum of 13 publications in 2008

YearPublications
19802
19831
19841
19851
19881
19891
19912
19921
19932
19941
19953
19964
19973
19982
19997
20003
20013
20028
20033
20045
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20064
20072
200813
20099
20107
20117
201210
201310
20147
20154
20164
20178
20185
20195
20202

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Adenosine Receptors
Blood Cells
Cell Cycle Control
Hematopoietic Stem Cells
Megakaryocyte
Platelet
Polyploidy
Vascular Biology

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700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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