Katya Ravid, DSc
Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine

PhD, Technion - Israel Institute of Technology
DSc, Technion - Israel Institute of Technology



Platelet aggregation plays a central role in thrombosis and hemostasis, which are central to vascular disease. In the platelet lineage, the early committed cells undergo a unique cell cycle leading to the formation of polyploid megakaryocytes prior to their fragmentation into platelets. Our research focuses on mechanisms that regulate lineage commitment and the subsequent steps of cellular maturation of bone marrow cells into polyploid megakaryocytes. We reported that polyploidy also develops in aging vascular cells, and in other cell types under stress, and mechanisms of control of polyploidy and its relevance to disease states are investigated. An ongoing related project involves the molecular characterization of platelet and vascular adenosine receptors, and exploration of their role in cellular function and lineage development. The systems used include primary bone marrow cultures, as well as transgenic and knock out mouse models.

Professor
Boston University School of Medicine
Biochemistry


Director
Boston University School of Medicine
Medicine
Evans Center for Interdisciplinary Biomedical Research

Director
Boston University
BU Interdisciplinary Biomedical Research Office


Director, Master of Science Program in Biomedical Research
Boston University School of Medicine
Medicine


Mentor for Graduate Medical Students
Boston University School of Medicine, Graduate Medical Sciences


Center Faculty Member
Boston University School of Medicine
Cardiovascular Institute (Whitaker)



2016 Fulbright : Fulbright Research Scholar Award
2016-2017 Aarhus University, Denmark : International Advisory Board
2014 Weizmann Institute: Weizmann Institute Professorship Award
2014 American Association for the Advancement of Science: Elected Fellow
2013 Boston University School of Medicine: Robert Dawson Evans Special Recognition Teaching Award
2013-2016 American Society of Hematology: Chair, Thrombosis and Vascular Biology Scientific Committee
2011-2013 Gordon Research Conference-Cell Biology of Megakaryocytes and Platelets: Vice Chair & Chair
2009 University of Sydney : International Visiting Professor Fellowship Award
2006 Boston University School of Medicine : Educator of the Year Award, Graduate Medical Sciences
2000-2005 American Heart Association: Established Investigator Award
1997 American Heart Association: Grant-In-Aid Award for Young Investigators
1987 Weizmann Institute: Weizmann Postdoctoral Fellowship Award
1982 Technion: Gutwirth Prize for Outstanding Graduate Students


A PATH TO THROMBOSIS IN PRIMARY MYELOFIBROSIS
12/24/2017 - 11/30/2021 (PI)
NIH/National Heart, Lung, and Blood Institute
1R01HL136363-01A1

MECHANISM OF BONE MARROW NEOPLASM-INDUCED OSTEOSCLEROSIS
05/01/2018 - 04/30/2020 (Multi-PI)
PI: Katya Ravid, DSc
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
1R21AR072748-01

TRAINING PROGRAM IN CARDIOVASCULAR BIOLOGY: PRE-DOCTORAL
12/01/2014 - 11/30/2019 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL007969-14

LYSYL OXIDASE PHARMACOLOGICAL INHIBITION OF BONE MAROW FIBROSIS
03/01/2016 - 10/31/2018 (PI)
Pharmaxis

MECHANISMS REGULATING MEGAKARYOCYTE DEVELOPMENT
04/01/2012 - 09/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL080442-09

NANOPLATFORMS FOR IMAGING BONE MARROW FIBROSIS
10/01/2014 - 09/30/2016 (PI)
MPN Research Foundation

MECHANISMS REGULATING MEGAKARYOCTE DEVELOPMENT
04/01/2012 - 03/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
2R01HL080442-06A1

TRAINING IN CARDIOVASCULAR BIOLOGY: PREDOCTORAL
07/01/2001 - 11/30/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL007969-10

TRAINING IN CARDIOVASCULAR BIOLOGY: PREDOCTORAL
07/01/2011 - 06/30/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL007969-09

ADENOSINE RECEPTORS AND ATHEROGENESIS
04/01/2009 - 03/31/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL093149-04

Showing 10 of 14 results. Show All Results



Yr Title Project-Sub Proj Pubs
2018 Mechanism of Bone Marrow Neoplasm-Induced Osteosclerosis 1R21AR072748-01
2018 A path to thrombosis in primary myelofibrosis 1R01HL136363-01A1
2018 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-14 45
2017 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-13 45
2016 Training Program in Cardiovascular Biology: Pre-Doctoral 5T32HL007969-12 45
2015 Mechanisms Regulating Megakaryocyte Development 5R01HL080442-09 14
2015 Training Program in Cardiovascular Biology: Pre-Doctoral 2T32HL007969-11 45
2014 Mechanisms Regulating Megakaryocyte Development 5R01HL080442-08 14
2013 2013 Cell Biology of Megakaryocytes and Platelets GRC &GRS 1R13HL117369-01
2013 Mechanisms Regulating Megakaryocyte Development 5R01HL080442-07 14
Showing 10 of 54 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Artuz CM, Knights AJ, Funnell APW, Gonda TJ, Ravid K, Pearson RCM, Quinlan KGR, Crossley M. Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules. Biotechnol Rep (Amst). 2018 Dec; 20:e00285. PMID: 30364711.
     
  2. Koupenova M, Ravid K. Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity. Front Pharmacol. 2018; 9:37. PMID: 29441021.
     
  3. Kolachalama VB, Shashar M, Alousi F, Shivanna S, Rijal K, Belghasem ME, Walker J, Matsuura S, Chang GH, Gibson CM, Dember LM, Francis JM, Ravid K, Chitalia VC. Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans. J Am Soc Nephrol. 2018 Mar; 29(3):1063-1072.View Related Profiles. PMID: 29343519; DOI: 10.1681/ASN.2017080929;.
     
  4. Leiva O, Leon C, Kah Ng S, Mangin P, Gachet C, Ravid K. The role of extracellular matrix stiffness in megakaryocyte and platelet development and function. Am J Hematol. 2018 Mar; 93(3):430-441. PMID: 29247535.
     
  5. Shashar M, Belghasem ME, Matsuura S, Walker J, Richards S, Alousi F, Rijal K, Kolachalama VB, Balcells M, Odagi M, Nagasawa K, Henderson JM, Gautam A, Rushmore R, Francis J, Kirchhofer D, Kolandaivelu K, Sherr DH, Edelman ER, Ravid K, Chitalia VC. Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk. Sci Transl Med. 2017 Nov 22; 9(417).View Related Profiles. PMID: 29167396; DOI: 10.1126/scitranslmed.aam8475;.
     
  6. Ravid K, Seta F, Center D, Waters G, Coleman D. Catalyzing Interdisciplinary Research and Training: Initial Outcomes and Evolution of the Affinity Research Collaboratives Model. Acad Med. 2017 Oct; 92(10):1399-1405.View Related Profiles. PMID: 28445220.
     
  7. Zhang A, Rijal K, Ng SK, Ravid K, Chitalia V. A mass spectrometric method for quantification of tryptophan-derived uremic solutes in human serum. J Biol Methods. 2017; 4(3).View Related Profiles. PMID: 29707597.
     
  8. Gordon CE, Chitalia VC, Sloan JM, Salant DJ, Coleman DL, Quillen K, Ravid K, Francis JM. Thrombotic Microangiopathy: A Multidisciplinary Team Approach. Am J Kidney Dis. 2017 Nov; 70(5):715-721.View Related Profiles. PMID: 28720207.
     
  9. Abbonante V, Chitalia V, Rosti V, Leiva O, Matsuura S, Balduini A, Ravid K. Upregulation of lysyl oxidase and adhesion to collagen of human megakaryocytes and platelets in primary myelofibrosis. Blood. 2017 08 10; 130(6):829-831.View Related Profiles. PMID: 28592432.
     
  10. Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK. Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest. 2017 06 01; 127(6):2438. PMID: 28569735.
     
Showing 10 of 147 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 147 publications over 34 distinct years, with a maximum of 13 publications in 2008

YearPublications
19802
19831
19841
19851
19881
19891
19912
19921
19932
19941
19953
19964
19973
19982
19997
20003
20013
20028
20033
20045
20054
20064
20072
200813
20099
20107
20117
201210
201310
20147
20154
20164
20178
20184
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Adenosine Receptors
Blood Cells
Cell Cycle Control
Hematopoietic Stem Cells
Megakaryocyte
Platelet
Polyploidy
Vascular Biology
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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