Phillip Stone | Profiles RNS

Phillip J. Stone, PhD

Emeritus Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, Temple University
MA, University of Pennsylvania
BS, Swarthmore College

Websites

	Biochemistry Faculty
	LinkedIn
	ResearchGate

ORCID : 0000-0001-6220-690X

Dr. Stone is Emeritus Professor of Biochemistry at Chobanian and Avedisian School of Medicine. He began in 1971 as a postdoc for Marrott Sinex, the Chair of Biochemistry at that time with a second postdoc in Carl Franzblau’s lab beginning in 1973, followed by a Young Investigator Award, NHLBI. Besides his current responsibilities as Assistant Dean of Admissions for the Medical School, he is also the department representative on the Institutional Animal Care and Use Committee. Dr. Stone also teaches in MD512/OH751 (Dental Biochemistry) the myoglobin and hemoglobin section and supervise student presented cases on sickle cell disease in dental medicine. He holds two patents: Measuring Connective Tissue Breakdown Products in Body Fluids. U.S. Patent No. 5,217,903 issued 6/8/93 and Measuring Tissue Breakdown Products in Body Fluids. U.S. Patent No. 5,354,662 issued 10/11/94.

Assistant Dean
Boston University Chobanian & Avedisian School of Medicine
Admissions

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Initial Assessment of Elastese Inhibitors from SolMap Pharmaceuticals for Treatment of Emphysema
06/01/2007 - 05/31/2009 (PI)
SolMap

Functional Repair of Elastin with Recomb. Tropoelastin
09/25/2002 - 08/31/2006 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5 R21 EB00988 03

Mechanisms of Perturbation of Pulmonary Lysyl Oxidase by Cigarette Smoke
08/01/2002 - 01/31/2006 (Co-PI)
PI: Wande Li, MD
Philip Morris Inc

Lung Connective Tissue: Responses to Injury and Repair
12/01/1996 - 11/30/2001 (Co-PI)
NIH/National Heart, Lung, and Blood Institute
5 P01 HL46902 10

Title

Yr	Title	Project-Sub Proj	Pubs
2004	Functional Repair of Elastin with Recomb. Tropoelastin	5R21EB000988-03	3
2003	Functional Repair of Elastin with Recomb. Tropoelastin	5R21EB000988-02	3
2002	Functional Repair of Elastin with Recomb. Tropoelastin	1R21EB000988-01	3
2001	EXTRACELLULAR REPAIR OF LUNG ELASTIC FIBERS	5P01HL046902-10-3	80
2001	TROPOELASTIN REQUIREMENT FOR EXTRACELLULAR REPAIR OF LUNG ELASTIN FIBERS	3P41RR010888-05S1-69	259
2000	TROPOELASTIN REQUIREMENT FOR EXTRACELLULAR REPAIR OF LUNG ELASTIN FIBERS	5P41RR010888-05-69	259
2000	EXTRACELLULAR REPAIR OF LUNG ELASTIC FIBERS	5P01HL046902-09-3	80
1999	TROPOELASTIN REQUIREMENT FOR EXTRACELLULAR REPAIR OF LUNG ELASTIN FIBERS	5P41RR010888-04-69	259
1999	EXTRACELLULAR REPAIR OF LUNG ELASTIC FIBERS	5P01HL046902-08-3	80
1998	EXTRACELLULAR REPAIR OF LUNG ELASTIC FIBERS	2P01HL046902-07-3	80

Showing 10 of 17 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Seidl SE, Pessolano LG, Bishop CA, Best M, Rich CB, Stone PJ, Schreiber BM. Toll-like receptor 2 activation and serum amyloid A regulate smooth muscle cell extracellular matrix. PLoS One. 2017; 12(3):e0171711.View Related Profiles.

Schreiber, Barbara
Pessolano, Lawrence
Stone, Phillip

PMID: 28257481; PMCID: PMC5336220; DOI: 10.1371/journal.pone.0171711;

Pessolano LG, Sullivan CP, Seidl SE, Rich CB, Liscum L, Stone PJ, Sipe JD, Schreiber BM. Trafficking of endogenous smooth muscle cell cholesterol: a role for serum amyloid A and interleukin-1ß. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2741-50.View Related Profiles.

Schreiber, Barbara
Pessolano, Lawrence
Stone, Phillip

PMID: 22995521; PMCID: PMC3559242; DOI: 10.1161/ATVBAHA.112.300243;

Isenberg BC, Backman DE, Kinahan ME, Jesudason R, Suki B, Stone PJ, Davis EC, Wong JY. Micropatterned cell sheets with defined cell and extracellular matrix orientation exhibit anisotropic mechanical properties. J Biomech. 2012 Mar 15; 45(5):756-61.View Related Profiles.

Suki, Bela
Wong, Joyce
Stone, Phillip

PMID: 22177672; DOI: 10.1016/j.jbiomech.2011.11.015;

Guarnieri F, Spencer JL, Lucey EC, Nugent MA, Stone PJ. A human surfactant peptide-elastase inhibitor construct as a treatment for emphysema. Proc Natl Acad Sci U S A. 2010 Jun 8; 107(23):10661-6.View Related Profiles.

Spencer, Jean
Nugent, Matthew
Stone, Phillip

PMID: 20534582; PMCID: PMC2890802; DOI: 10.1073/pnas.1001349107;

Zhao Y, Chen L, Gao S, Toselli P, Stone P, Li W. The critical role of the cellular thiol homeostasis in cadmium perturbation of the lung extracellular matrix. Toxicology. 2010 Jan 12; 267(1-3):60-9.View Related Profiles.

Toselli, Paul
Stone, Phillip
Li, Wande
Zhao, Yinzhi

PMID: 19879314; PMCID: PMC2814991; DOI: 10.1016/j.tox.2009.10.021;

Ritter MC, Jesudason R, Majumdar A, Stamenovic D, Buczek-Thomas JA, Stone PJ, Nugent MA, Suki B. A zipper network model of the failure mechanics of extracellular matrices. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):1081-6.View Related Profiles.

Suki, Bela
Stamenovic, Dimitrije
Buczek-Thomas, JoAnn
Nugent, Matthew
Stone, Phillip

PMID: 19144920; PMCID: PMC2633546; DOI: 10.1073/pnas.0808414106;

Seidl S, Rich CB, Sullivan CP, Stone PJ, Schreiber BM. Arteriosclerosis Thrombosis and Vascular Biology. Serum Amyloid A Downregulates Elastin and Upregulates Matrix Metalloproteinase-9 Gene Expression in Smooth Muscle Cells. 2009.
Jesudason RE, Allen PG, Parameswaran H, Suki B, Stone PJ. American Thoracic Society 2009 International Conference. Interaction between Elastase Activity and Mechanical Forces in Lung Tissue Strips. San Diego. 2009. View Publication

Black LD, Allen PG, Morris SM, Stone PJ, Suki B. Mechanical and failure properties of extracellular matrix sheets as a function of structural protein composition. Biophys J. 2008 Mar 1; 94(5):1916-29.View Related Profiles.

Suki, Bela
Stone, Phillip

PMID: 17993498; PMCID: PMC2242735; DOI: 10.1529/biophysj.107.107144;

Gao S, Zhao Y, Kong L, Toselli P, Chou IN, Stone P, Li W. Cloning and characterization of the rat lysyl oxidase gene promoter: identification of core promoter elements and functional nuclear factor I-binding sites. J Biol Chem. 2007 Aug 31; 282(35):25322-37.View Related Profiles.

Toselli, Paul
Stone, Phillip
Li, Wande
Zhao, Yinzhi

PMID: 17597074

Showing 10 of 126 results. Show More

Chou DK, Zhao Y, Gao S, Chou IN, Toselli P, Stone P, Li W. Perturbation of copper (Cu) homeostasis and expression of Cu-binding proteins in cadmium-resistant lung fibroblasts. Toxicol Sci. 2007 Sep; 99(1):267-76.View Related Profiles.

Toselli, Paul
Stone, Phillip
Li, Wande
Zhao, Yinzhi

PMID: 17584760

Jesudason R, Black L, Majumdar A, Stone P, Suki B. Differential effects of static and cyclic stretching during elastase digestion on the mechanical properties of extracellular matrices. J Appl Physiol (1985). 2007 Sep; 103(3):803-11.View Related Profiles.

Suki, Bela
Stone, Phillip

PMID: 17540839; DOI: 10.1152/japplphysiol.00057.2007;

Spencer JL, Stone PJ, Nugent MA. New insights into the inhibition of human neutrophil elastase by heparin. Biochemistry. 2006 Aug 1; 45(30):9104-20.View Related Profiles.

Spencer, Jean
Nugent, Matthew
Stone, Phillip

PMID: 16866356

DiCamillo SJ, Yang S, Panchenko MV, Toselli PA, Naggar EF, Rich CB, Stone PJ, Nugent MA, Panchenko MP. Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2006 Aug; 291(2):L232-43.View Related Profiles.

Panchenko, Maria
Nugent, Matthew
Toselli, Paul
Stone, Phillip

PMID: 16473861

Zhao Y, Gao S, Chou IN, Toselli P, Stone P, Li W. Inhibition of the expression of lysyl oxidase and its substrates in cadmium-resistant rat fetal lung fibroblasts. Toxicol Sci. 2006 Apr; 90(2):478-89.View Related Profiles.

Toselli, Paul
Stone, Phillip
Li, Wande
Zhao, Yinzhi

PMID: 16432278

Berk JL, Hatch CA, Morris SM, Stone PJ, Goldstein RH. Hypoxia suppresses elastin repair by rat lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2005 Dec; 289(6):L931-6.View Related Profiles.

Berk, John
Stone, Phillip
Goldstein, Ronald

PMID: 16055482

Gao S, Chen K, Zhao Y, Rich CB, Chen L, Li SJ, Toselli P, Stone P, Li W. Transcriptional and posttranscriptional inhibition of lysyl oxidase expression by cigarette smoke condensate in cultured rat fetal lung fibroblasts. Toxicol Sci. 2005 Sep; 87(1):197-203.View Related Profiles.

Toselli, Paul
Stone, Phillip
Li, Wande
Zhao, Yinzhi

PMID: 15933228; PMCID: PMC1283112; DOI: 10.1093/toxsci/kfi212;

Leach JB, Wolinsky JB, Stone PJ, Wong JY. Crosslinked alpha-elastin biomaterials: towards a processable elastin mimetic scaffold. Acta Biomater. 2005 Mar; 1(2):155-64.View Related Profiles.

Wong, Joyce
Stone, Phillip

PMID: 16701792

Black LD, Brewer KK, Morris SM, Schreiber BM, Toselli P, Nugent MA, Suki B, Stone PJ. Effects of elastase on the mechanical and failure properties of engineered elastin-rich matrices. J Appl Physiol (1985). 2005 Apr; 98(4):1434-41.View Related Profiles.

Schreiber, Barbara
Suki, Bela
Nugent, Matthew
Toselli, Paul
Stone, Phillip

PMID: 15640390

Hofmann CS, Wang X, Sullivan CP, Toselli P, Stone PJ, McLean SE, Mecham RP, Schreiber BM, Sonenshein GE. B-Myb represses elastin gene expression in aortic smooth muscle cells. J Biol Chem. 2005 Mar 4; 280(9):7694-701.View Related Profiles.

Schreiber, Barbara
Sonenshein, Gail
Toselli, Paul
Stone, Phillip

PMID: 15615710

Chen LJ, Zhao Y, Gao S, Chou IN, Toselli P, Stone P, Li W. Downregulation of lysyl oxidase and upregulation of cellular thiols in rat fetal lung fibroblasts treated with cigarette smoke condensate. Toxicol Sci. 2005 Feb; 83(2):372-9.View Related Profiles.

Toselli, Paul
Stone, Phillip
Li, Wande
Zhao, Yinzhi

PMID: 15509664

Jones MR, Zhao Z, Sullivan CP, Schreiber BM, Stone PJ, Toselli PA, Kagan HM, Cohen RA, Ravid K. A(3) adenosine receptor deficiency does not influence atherogenesis. J Cell Biochem. 2004 Aug 1; 92(5):1034-43.View Related Profiles.

Schreiber, Barbara
Kagan, Herbert
Ravid, Katya
Jones, Matthew
Toselli, Paul
Stone, Phillip
Cohen, Richard

PMID: 15258925

Hofmann CS, Sullivan CP, Jiang HY, Stone PJ, Toselli P, Reis ED, Chereshnev I, Schreiber BM, Sonenshein GE. B-Myb represses vascular smooth muscle cell collagen gene expression and inhibits neointima formation after arterial injury. Arterioscler Thromb Vasc Biol. 2004 Sep; 24(9):1608-13.View Related Profiles.

Schreiber, Barbara
Sonenshein, Gail
Toselli, Paul
Stone, Phillip

PMID: 15256398

Buczek-Thomas JA, Lucey EC, Stone PJ, Chu CL, Rich CB, Carreras I, Goldstein RH, Foster JA, Nugent MA. Elastase mediates the release of growth factors from lung in vivo. Am J Respir Cell Mol Biol. 2004 Sep; 31(3):344-50.View Related Profiles.

Carreras, Isabel
Buczek-Thomas, JoAnn
Nugent, Matthew
Stone, Phillip
Goldstein, Ronald

PMID: 15191913

Panchenko MP, DiCamillo SJ, Stone PJ, Yang SH. Repression of elastogenesis involves EGFR signaling via MEK/ERK cascade and actin cytoskeleton reorganization en route for tropoelastin mRNA destabilization. The FASEB Journal. 2004; 18.

Rich CB, Carreras I, Lucey EC, Jaworski JA, Buczek-Thomas JA, Nugent MA, Stone P, Foster JA. Transcriptional regulation of pulmonary elastin gene expression in elastase-induced injury. Am J Physiol Lung Cell Mol Physiol. 2003 Aug; 285(2):L354-62.View Related Profiles.

Carreras, Isabel
Buczek-Thomas, JoAnn
Nugent, Matthew
Stone, Phillip

PMID: 12679320

Buczek-Thomas JA, Chu CL, Rich CB, Stone PJ, Foster JA, Nugent MA. Heparan sulfate depletion within pulmonary fibroblasts: implications for elastogenesis and repair. J Cell Physiol. 2002 Sep; 192(3):294-303.View Related Profiles.

Buczek-Thomas, JoAnn
Nugent, Matthew
Stone, Phillip

PMID: 12124775

DiCamillo SJ, Carreras I, Panchenko MV, Stone PJ, Nugent MA, Foster JA, Panchenko MP. Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts. J Biol Chem. 2002 May 24; 277(21):18938-46.View Related Profiles.

Carreras, Isabel
Panchenko, Maria
Nugent, Matthew
Stone, Phillip

PMID: 11889128

Stone PJ, Morris SM, Griffin S, Mithieux S, Weiss AS. Building Elastin. Incorporation of recombinant human tropoelastin into extracellular matrices using nonelastogenic rat-1 fibroblasts as a source for lysyl oxidase. Am J Respir Cell Mol Biol. 2001 Jun; 24(6):733-9. PMID: 11415939

Gottlieb DJ, Luisetti M, Stone PJ, Allegra L, Cantey-Kiser JM, Grassi C, Snider GL. Short-term supplementation therapy does not affect elastin degradation in severe alpha(1)-antitrypsin deficiency. The American-Italian AATD Study Group. Am J Respir Crit Care Med. 2000 Dec; 162(6):2069-72. PMID: 11112116

Stone PJ. Potential use of collagen and elastin degradation markers for monitoring liver fibrosis in schistosomiasis. Acta Trop. 2000 Oct 23; 77(1):97-9. PMID: 10996125

Hsiao H, Stone PJ, Toselli P, Rosenbloom J, Franzblau C, Schreiber BM. The role of the carboxy terminus of tropoelastin in its assembly into the elastic fiber. Connect Tissue Res. 1999; 40(2):83-95.View Related Profiles.

Schreiber, Barbara
Franzblau, Carl
Toselli, Paul
Stone, Phillip

PMID: 10761633

Perrin S, Rich CB, Morris SM, Stone PJ, Foster JA. The zebrafish swimbladder: A simple model for lung elastin injury and repair. Connect Tissue Res. 1999; 40(2):105-12. PMID: 10761635

Lucey EC, Goldstein RH, Stone PJ, Snider GL. Remodeling of alveolar walls after elastase treatment of hamsters. Results of elastin and collagen mRNA in situ hybridization. Am J Respir Crit Care Med. 1998 Aug; 158(2):555-64.View Related Profiles.

Stone, Phillip
Goldstein, Ronald

PMID: 9700135

Stone PJ, Beiser A, Gottlieb DJ. Circadian variation of urinary excretion of elastin and collagen crosslinks. Proc Soc Exp Biol Med. 1998 Jul; 218(3):229-33.View Related Profiles.

Beiser, Alexa
Stone, Phillip

PMID: 9648941

Morris SM, Thomas KM, Rich CB, Stone PJ. Degradation and repair of elastic fibers in rat lung interstitial fibroblast cultures. Anat Rec. 1998 Apr; 250(4):397-407. PMID: 9566529

Afdhal NH, Keaveny AP, Cohen SB, Nunes DP, Maldonado N, O'Brien M, Stone PJ. Urinary assays for desmosine and hydroxylysylpyridinoline in the detection of cirrhosis. J Hepatol. 1997 Dec; 27(6):993-1002.View Related Profiles.

Nunes, David
O'Brien, Michael
Stone, Phillip

PMID: 9453424

Stone PJ, Morris SM, Thomas KM, Schuhwerk K, Mitchelson A. Repair of elastase-digested elastic fibers in acellular matrices by replating with neonatal rat-lung lipid interstitial fibroblasts or other elastogenic cell types. Am J Respir Cell Mol Biol. 1997 Sep; 17(3):289-301. PMID: 9308916

Stone PJ, Lucey EC, Snider GL, Franzblau C. Distribution of elastin in hamsters and the turnover rates of different elastin pools. Proc Soc Exp Biol Med. 1997 May; 215(1):94-101.View Related Profiles.

Year	Publications
1981	2
1982	3
1983	9
1984	2
1985	6
1986	6
1987	4
1988	4
1989	3
1990	6
1991	6
1992	5
1993	5
1994	2
1995	7
1996	2
1997	4
1998	3
1999	2
2000	2
2001	1
2002	2
2003	1
2004	6
2005	4
2006	3
2007	4
2009	4
2010	1
2011	1
2012	1
2017	1