Maria Isabel Dominguez | Profiles RNS

Maria Isabel Dominguez, PhD

Assistant Professor

Boston University School of Medicine

Dept of Medicine

Hematology & Medical Oncology

PhD, Universidad Autónoma de Madrid
MSc, University of the Basque Country

Websites

Department of Medicine Faculty

ORCID : 0000-0001-9617-4141

My research interest is to understand the cascade of intracellular events that leads to the activation of Wnt signaling and the biological role of the Wnt pathway during organ development and maintenance. We have two areas of interest:

Our first area of interest is to characterize the molecular mechanism leading to activation (stabilization and nuclear translocation) of ß-catenin, the key intracellular Wnt component that is activated in many human tumors. For this, we are using Xenopus embryos, mammalian cell lines, and mice ablated for CK2 catalytic subunits.

Our second area of interest is to characterize the cellular and molecular mechanisms regulated by Wnt/ß-catenin signaling during embryonic organ morphogenesis. For this we are using mice ablated for CK2 subunits and Xenopus embryos.

Assistant Dean
Boston University School of Medicine
Diversity & Multicultural Affairs

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

Boston Medical Center

2013 Department of Medicine, Boston University School of Medicine: Faculty Development Grant

2008 Department of Medicine, Boston University School of Medicine: Faculty Development Grant

2007-2008 Karin Grunebaum Cancer Research Foundation: Junior Faculty Cancer Research Award

2007-2008 Department of Medicine, Boston University School of Medicine: Pilot Project Grant

2003-2004 Department of Medicine, Boston University School of Medicine: Pilot Project Grant

2002-2003 Cancer Center, BU School of Medicine: American Cancer Society Institutional Research Grant

1998 The Company of Biologists: Travel Fellowship to Attend the 7th International Xenopus Meeting

1996-1998 Basque Government: Postdoctoral Fellowship

1994-1996 Spanish Government: Postdoctoral Fellowship

1990-1994 Basque Government: Postgraduate Fellowship

1988-1989 Iberduero S.A.: Postgraduate Fellowship

1987-1988 Basque Government: Undergraduate Fellowship

STaRS at BU - Summer Training as Research Scholars at Boston University
05/01/2018 - 04/30/2023 (Multi-PI)
PI: Maria Isabel Dominguez, PhD
NIH/National Heart, Lung, and Blood Institute
2R25HL118693-06

Control of Embryonic Development by CK2: CK2 as a Core Wnt/beta-catenin component
08/01/2011 - 06/30/2017 (PI)
NIH-NIGMS
5R01 GM098367-04

Effect of CK2 disregulation on heart morphogenesis
07/01/2010 - 06/30/2014 (PI)
American Heart Assoc

Role of Protein Kinese Ck2 Alpha in Cardiac Development
07/01/2007 - 06/30/2010 (PI)
American Heart Assoc

Yr	Title	Project-Sub Proj	Pubs
2014	Control of embryonic development by CK2: CK2 as a core Wnt/beta-catenin component	5R01GM098367-04	5
2013	Control of embryonic development by CK2: CK2 as a core Wnt/beta-catenin component	5R01GM098367-03	5
2012	Control of embryonic development by CK2: CK2 as a core Wnt/beta-catenin component	5R01GM098367-02	5
2011	Control of embryonic development by CK2: CK2 as a core Wnt/beta-catenin component	1R01GM098367-01	5

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Lee M, Chea K, Pyda R, Chua M, Dominguez I. Comparative Analysis of Non-viral Transfection Methods in Mouse Embryonic Fibroblast Cells. J Biomol Tech. 2017 Jul; 28(2):67-74. PMID: 28507462; DOI: 10.7171/jbt.17-2802-003;.

Chua MM, Ortega CE, Sheikh A, Lee M, Abdul-Rassoul H, Hartshorn KL, Dominguez I. CK2 in Cancer: Cellular and Biochemical Mechanisms and Potential Therapeutic Target. Pharmaceuticals (Basel). 2017 Jan 28; 10(1).View Related Profiles.

Hartshorn, Kevan
Dominguez, Maria Isabel

PMID: 28134850; DOI: 10.3390/ph10010018;.

Marivin A, Leyme A, Parag-Sharma K, DiGiacomo V, Cheung AY, Nguyen LT, Dominguez I, Garcia-Marcos M. Dominant-negative Ga subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease. Sci Signal. 2016 Apr 12; 9(423):ra37.View Related Profiles.

Leyme, Anthony
Dominguez, Maria Isabel
Garcia-Marcos, Mikel

PMID: 27072656; PMCID: PMC4870087; DOI: 10.1126/scisignal.aad2429;.

Apfel J, Parikh JR, Reischmann P, Ewing RM, Müller O, Xia Y, Dominguez I. Systems Biology of Cancer Editor: Sam Thiagalingam. The Wnt signaling network in Cancer. Cambridge University Press. 2015.

Ortega C, Prince-Wright L, Dominguez I. Proceedings of the CK2-VII meeting. Editors Khalil Ahmed, Olaf Issinger and Ryszard Szyska. Role of CK2 in organ formation. 2015.

Ortega CE, Seidner Y, Dominguez I. Mining CK2 in cancer. PLoS One. 2014; 9(12):e115609. PMID: 25541719; PMCID: PMC4277308; DOI: 10.1371/journal.pone.0115609;.

Siriwardana NS, Meyer R, Havasi A, Dominguez I, Panchenko MV. Cell cycle-dependent chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex. Cell Cycle. 2014; 13(12):1885-901.View Related Profiles.

Havasi, Andrea
Dominguez, Maria Isabel
Panchenko, Maria

PMID: 24739512; PMCID: PMC4111752; DOI: 10.4161/cc.28759;.

Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I, Ehler E. Two distinct phosphorylation events govern the function of muscle FHOD3. Cell Mol Life Sci. 2013 Mar; 70(5):893-908.View Related Profiles.

Dominguez, Maria Isabel
Toselli, Paul

PMID: 23052206; PMCID: PMC3696992; DOI: 10.1007/s00018-012-1154-7;.

Papanicolaou KN, Kikuchi R, Ngoh GA, Coughlan KA, Dominguez I, Stanley WC, Walsh K. Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. Circ Res. 2012 Sep 28; 111(8):1012-26.View Related Profiles.

Ngoh, Gladys
Walsh, Kenneth
Coughlan, Kimberly
Dominguez, Maria Isabel
Kikuchi, Ryosuke

PMID: 22904094; PMCID: PMC3518037.

Imbrie GA, Wu H, Seldin DC, Dominguez I. Asymmetric Localization of CK2a During Xenopus Oogenesis. Hum Genet Embryol. 2012 May 05; Suppl 4(1):11328. PMID: 25346867.

Showing 10 of 41 results. Show More

Revuelta-Cervantes J, Macias Alvarez L, Dominguez I. The Wiley-IUBMB Series on Biochemistry and Molecular Biology: Protein Kinase CK2. Editor: Lorenzo Pinna. CK2 in embryonic development. Wiley-Blackwell Publishing. John Wiley & Sons, Inc. 2012.

Dominguez I, Degano IR, Chea K, Cha J, Toselli P, Seldin DC. CK2a is essential for embryonic morphogenesis. Mol Cell Biochem. 2011 Oct; 356(1-2):209-16.View Related Profiles.

Seldin, David
Dominguez, Maria Isabel
Toselli, Paul

PMID: 21761203; PMCID: PMC3756899; DOI: 10.1007/s11010-011-0961-8;.

Currier N, Chea K, Hlavacova M, Sussman DJ, Seldin DC, Dominguez I. Dynamic expression of a LEF-EGFP Wnt reporter in mouse development and cancer. Genesis. 2010 Mar; 48(3):183-94.View Related Profiles.

Seldin, David
Dominguez, Maria Isabel

PMID: 20146356; PMCID: PMC3399184; DOI: 10.1002/dvg.20604;.

Wu H, Symes K, Seldin DC, Dominguez I. Threonine 393 of beta-catenin regulates interaction with Axin. J Cell Biochem. 2009 Sep 1; 108(1):52-63.View Related Profiles.

Seldin, David
Symes, Karen
Dominguez, Maria Isabel

PMID: 19565571; PMCID: PMC3398408; DOI: 10.1002/jcb.22260;.

Dominguez I, Sonenshein GE, Seldin DC. Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer. Cell Mol Life Sci. 2009 Jun; 66(11-12):1850-7.View Related Profiles.

Seldin, David
Sonenshein, Gail
Dominguez, Maria Isabel

PMID: 19387549; DOI: 10.1007/s00018-009-9153-z;.

Bryja V, Schambony A, Cajánek L, Dominguez I, Arenas E, Schulte G. Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways. EMBO Rep. 2008 Dec; 9(12):1244-50. PMID: 18953287; PMCID: PMC2608197; DOI: 10.1038/embor.2008.193;.

Chitalia VC, Foy RL, Bachschmid MM, Zeng L, Panchenko MV, Zhou MI, Bharti A, Seldin DC, Lecker SH, Dominguez I, Cohen HT. Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. Nat Cell Biol. 2008 Oct; 10(10):1208-16.View Related Profiles.

Bharti, Ajit
Seldin, David
Cohen, Herbert
Dominguez, Maria Isabel
Panchenko, Maria
Bachschmid, Markus
Zhou, Mina
Chitalia, Vipul

PMID: 18806787; PMCID: PMC2830866; DOI: 10.1038/ncb1781;.

Seldin DC, Lou DY, Toselli P, Landesman-Bollag E, Dominguez I. Gene targeting of CK2 catalytic subunits. Mol Cell Biochem. 2008 Sep; 316(1-2):141-7.View Related Profiles.

Seldin, David
Landesman, Esther
Dominguez, Maria Isabel
Toselli, Paul

PMID: 18594950; PMCID: PMC3696998; DOI: 10.1007/s11010-008-9811-8;.

Lou DY, Dominguez I, Toselli P, Landesman-Bollag E, O'Brien C, Seldin DC. The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development. Mol Cell Biol. 2008 Jan; 28(1):131-9.View Related Profiles.

Seldin, David
Landesman, Esther
Dominguez, Maria Isabel
Toselli, Paul

PMID: 17954558; PMCID: PMC2223292.

Farago M, Dominguez I, Landesman-Bollag E, Xu X, Rosner A, Cardiff RD, Seldin DC. Kinase-inactive glycogen synthase kinase 3beta promotes Wnt signaling and mammary tumorigenesis. Cancer Res. 2005 Jul 1; 65(13):5792-801.View Related Profiles.

Seldin, David
Landesman, Esther
Dominguez, Maria Isabel

PMID: 15994955.

Seldin DC, Landesman-Bollag E, Farago M, Currier N, Lou D, Dominguez I. CK2 as a positive regulator of Wnt signalling and tumourigenesis. Mol Cell Biochem. 2005 Jun; 274(1-2):63-7.View Related Profiles.

Seldin, David
Landesman, Esther
Dominguez, Maria Isabel

PMID: 16342409.

Dominguez I, Mizuno J, Wu H, Imbrie GA, Symes K, Seldin DC. A role for CK2alpha/beta in Xenopus early embryonic development. Mol Cell Biochem. 2005 Jun; 274(1-2):125-31.View Related Profiles.

Seldin, David
Symes, Karen
Dominguez, Maria Isabel

PMID: 16342412.

Currier N, Solomon SE, Demicco EG, Chang DL, Farago M, Ying H, Dominguez I, Sonenshein GE, Cardiff RD, Xiao ZX, Sherr DH, Seldin DC. Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors. Toxicol Pathol. 2005; 33(6):726-37.View Related Profiles.

Seldin, David
Sherr, David
Sonenshein, Gail
Dominguez, Maria Isabel
Xiao, Zhi-Xiong

PMID: 16263698.

Green JB, Dominguez I, Davidson LA. Self-organization of vertebrate mesoderm based on simple boundary conditions. Dev Dyn. 2004 Nov; 231(3):576-81. PMID: 15376320.

Dominguez I, Mizuno J, Wu H, Song DH, Symes K, Seldin DC. Protein kinase CK2 is required for dorsal axis formation in Xenopus embryos. Dev Biol. 2004 Oct 1; 274(1):110-24.View Related Profiles.

Seldin, David
Symes, Karen
Dominguez, Maria Isabel

PMID: 15355792.

Song DH, Dominguez I, Mizuno J, Kaut M, Mohr SC, Seldin DC. CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling. J Biol Chem. 2003 Jun 27; 278(26):24018-25.View Related Profiles.

Seldin, David
Dominguez, Maria Isabel

PMID: 12700239.

Dominguez I, Green JB. Missing links in GSK3 regulation. Dev Biol. 2001 Jul 15; 235(2):303-13. PMID: 11437438.

Dominguez I, Green JB. Dorsal downregulation of GSK3beta by a non-Wnt-like mechanism is an early molecular consequence of cortical rotation in early Xenopus embryos. Development. 2000 Feb; 127(4):861-8. PMID: 10648244.

Martínez-Gimeno C, Díaz-Meco MT, Domínguez I, Moscat J. Alterations in levels of different protein kinase C isotypes and their influence on behavior of squamous cell carcinoma of the oral cavity: epsilon PKC, a novel prognostic factor for relapse and survival. Head Neck. 1995 Nov-Dec; 17(6):516-25. PMID: 8847210.

Dominguez I, Itoh K, Sokol SY. Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8498-502. PMID: 7667318; PMCID: PMC41184.

Lozano J, Berra E, Municio MM, Diaz-Meco MT, Dominguez I, Sanz L, Moscat J. Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase. J Biol Chem. 1994 Jul 29; 269(30):19200-2. PMID: 8034680.

Diaz-Meco MT, Dominguez I, Sanz L, Dent P, Lozano J, Municio MM, Berra E, Hay RT, Sturgill TW, Moscat J. zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro. EMBO J. 1994 Jun 15; 13(12):2842-8. PMID: 8026469; PMCID: PMC395165.

Sanz L, Berra E, Municio MM, Dominguez I, Lozano J, Johansen T, Moscat J, Diaz-Meco MT. Zeta PKC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element. J Biol Chem. 1994 Apr 1; 269(13):10044-9. PMID: 8144503.

Arenzana-Seisdedos F, Fernandez B, Dominguez I, Jacqué JM, Thomas D, Diaz-Meco MT, Moscat J, Virelizier JL. Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes. J Virol. 1993 Nov; 67(11):6596-604. PMID: 8411362; PMCID: PMC238097.

Berra E, Diaz-Meco MT, Dominguez I, Municio MM, Sanz L, Lozano J, Chapkin RS, Moscat J. Protein kinase C zeta isoform is critical for mitogenic signal transduction. Cell. 1993 Aug 13; 74(3):555-63. PMID: 7688666.

Diaz-Meco MT, Berra E, Municio MM, Sanz L, Lozano J, Dominguez I, Diaz-Golpe V, Lain de Lera MT, Alcamí J, Payá CV, et al. A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation. Mol Cell Biol. 1993 Aug; 13(8):4770-5. PMID: 8336714; PMCID: PMC360103.

Dominguez I, Sanz L, Arenzana-Seisdedos F, Diaz-Meco MT, Virelizier JL, Moscat J. Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes. Mol Cell Biol. 1993 Feb; 13(2):1290-5. PMID: 8423794; PMCID: PMC359014.

Dominguez I, Diaz-Meco MT, Municio MM, Berra E, García de Herreros A, Cornet ME, Sanz L, Moscat J. Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes. Mol Cell Biol. 1992 Sep; 12(9):3776-83. PMID: 1508183; PMCID: PMC360243.

Diaz-Meco MT, Dominguez I, Sanz L, Municio MM, Berra E, Cornet ME, Garcia de Herreros A, Johansen T, Moscat J. Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals. Mol Cell Biol. 1992 Jan; 12(1):302-8. PMID: 1309592; PMCID: PMC364110.

Dominguez I, Marshall MS, Gibbs JB, García de Herreros A, Cornet ME, Graziani G, Diaz-Meco MT, Johansen T, McCormick F, Moscat J. Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. EMBO J. 1991 Nov; 10(11):3215-20. PMID: 1655413; PMCID: PMC453045.

García de Herreros A, Dominguez I, Diaz-Meco MT, Graziani G, Cornett ME, Guddal PH, Johansen T, Moscat J. Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21. J Biol Chem. 1991 Apr 15; 266(11):6825-9. PMID: 2016297.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 41 publications over 20 distinct years, with a maximum of 4 publications in 1993 and 2005 and 2012