Anthony Leyme, PhD
Scientist
Biogen
Analytical Development




Postdoctoral Fellow (Previously held)
Boston University Chobanian & Avedisian School of Medicine


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Maziarz M, Park JC, Leyme A, Marivin A, Garcia-Lopez A, Patel PP, Garcia-Marcos M. Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design. Cell. 2020 08 06; 182(3):770-785.e16.View Related Profiles. PMID: 32634377; PMCID: PMC7415655; DOI: 10.1016/j.cell.2020.06.020;
     
  2. Wang Y, Keith M, Leyme A, Bergelson S, Feschenko M. Monitoring long-term DNA storage via absolute copy number quantification by ddPCR. Anal Biochem. 2019 10 15; 583:113363. PMID: 31310737
     
  3. Marivin A, Morozova V, Walawalkar I, Leyme A, Kretov DA, Cifuentes D, Dominguez I, Garcia-Marcos M. GPCR-independent activation of G proteins promotes apical cell constriction in vivo. J Cell Biol. 2019 05 06; 218(5):1743-1763.View Related Profiles. PMID: 30948426; PMCID: PMC6504902; DOI: 10.1083/jcb.201811174;
     
  4. Maziarz M, Leyme A, Marivin A, Luebbers A, Patel PP, Chen Z, Sprang SR, Garcia-Marcos M. Atypical activation of the G protein Gaq by the oncogenic mutation Q209P. J Biol Chem. 2018 12 21; 293(51):19586-19599.View Related Profiles. PMID: 30352874; PMCID: PMC6314142; DOI: 10.1074/jbc.RA118.005291;
     
  5. Leyme A, Marivin A, Maziarz M, DiGiacomo V, Papakonstantinou MP, Patel PP, Blanco-Canosa JB, Walawalkar IA, Rodriguez-Davila G, Dominguez I, Garcia-Marcos M. Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein. Proc Natl Acad Sci U S A. 2017 11 28; 114(48):E10319-E10328.View Related Profiles. PMID: 29133411; PMCID: PMC5715746; DOI: 10.1073/pnas.1707992114;
     
  6. de Opakua AI, Parag-Sharma K, DiGiacomo V, Merino N, Leyme A, Marivin A, Villate M, Nguyen LT, de la Cruz-Morcillo MA, Blanco-Canosa JB, Ramachandran S, Baillie GS, Cerione RA, Blanco FJ, Garcia-Marcos M. Molecular mechanism of Gai activation by non-GPCR proteins with a Ga-Binding and Activating motif. Nat Commun. 2017 05 18; 8:15163.View Related Profiles. PMID: 28516903; PMCID: PMC5454376; DOI: 10.1038/ncomms15163;
     
  7. Parag-Sharma K, Leyme A, DiGiacomo V, Marivin A, Broselid S, Garcia-Marcos M. Membrane Recruitment of the Non-receptor Protein GIV/Girdin (Ga-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling. J Biol Chem. 2016 Dec 30; 291(53):27098-27111.View Related Profiles. PMID: 27864364; PMCID: PMC5207140; DOI: 10.1074/jbc.M116.764431;
     
  8. Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P. GIV/Girdin activates Gai and inhibits Gas via the same motif. Proc Natl Acad Sci U S A. 2016 09 27; 113(39):E5721-30.View Related Profiles. PMID: 27621449; PMCID: PMC5047194; DOI: 10.1073/pnas.1609502113;
     
  9. Marivin A, Leyme A, Parag-Sharma K, DiGiacomo V, Cheung AY, Nguyen LT, Dominguez I, Garcia-Marcos M. Dominant-negative Ga subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease. Sci Signal. 2016 Apr 12; 9(423):ra37.View Related Profiles. PMID: 27072656; PMCID: PMC4870087; DOI: 10.1126/scisignal.aad2429;
     
  10. Leyme A, Marivin A, Garcia-Marcos M. GIV/Girdin (Ga-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells. J Biol Chem. 2016 Apr 8; 291(15):8269-82.View Related Profiles. PMID: 26887938; PMCID: PMC4825026; DOI: 10.1074/jbc.M115.691550;
     
Showing 10 of 17 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 17 publications over 9 distinct years, with a maximum of 4 publications in 2016

YearPublications
20111
20122
20141
20153
20164
20172
20181
20192
20201

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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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