Keywords
Last Name

H. Christian Weber, MD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionGastroenterology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-6547
ORCID ORCID Icon0000-0001-9005-6988
Other Positions
TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine

 Research Expertise & Professional Interests
Expertise includes: Biology and pharmacology of G protein-coupled bombesin receptors in cancer and energy homeostasis; Clinical research in functional bowel disorders, neuroendocrinology, including acid-related disorders and long-term effects of gastric acid inhibition; and Natural products for the treatment of cancer, obesity, diabetes, and infections.

 Self-Described Keywords
  • Acid secretion
  • Bombesin
  • intracellular signaling
  • obesity
  • Proton Pump Inhibitors
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Weber HC. Gastrointestinal regulatory peptides. Curr Opin Endocrinol Diabetes Obes. 2017 Feb; 24(1):1-2. PMID: 27870640.
    View in: PubMed
  2. Weber HC. New treatment options for irritable bowel syndrome with predominant diarrhea. Curr Opin Endocrinol Diabetes Obes. 2017 Feb; 24(1):25-30. PMID: 27875419.
    View in: PubMed
  3. Weber HC. Overview of gastrointestinal regulatory peptides. Curr Opin Endocrinol Diabetes Obes. 2016 Feb; 23(1):1-2. PMID: 26702844.
    View in: PubMed
  4. Weber HC. Opioid-induced constipation in chronic noncancer pain. Curr Opin Endocrinol Diabetes Obes. 2016 Feb; 23(1):11-7. PMID: 26702846.
    View in: PubMed
  5. Liu Y, Qin XQ, Weber HC, Xiang Y, Liu C, Liu HJ, Yang H, Jiang J, Qu X. Bombesin Receptor-Activated Protein (BRAP) Modulates NF-?B Activation in Bronchial Epithelial Cells by Enhancing HDAC Activity. J Cell Biochem. 2016 May; 117(5):1069-77. PMID: 26460487.
    View in: PubMed
  6. Weber HC. Gastrointestinal peptides and itch sensation. Curr Opin Endocrinol Diabetes Obes. 2015 Feb; 22(1):29-33. PMID: 25485517.
    View in: PubMed
  7. Weber HC. Gastrointestinal regulatory peptides. Curr Opin Endocrinol Diabetes Obes. 2015 Feb; 22(1):1-2. PMID: 25485518.
    View in: PubMed
  8. Hermos JA, Quach L, Gagnon DR, Weber HC, Altincatal A, Cho K, Lawler EV, Grotzinger KM. Incident severe thrombocytopenia in veterans treated with pegylated interferon plus ribavirin for chronic hepatitis C infection. Pharmacoepidemiol Drug Saf. 2014 May; 23(5):480-8. PMID: 24677630.
    View in: PubMed
  9. Weber HC. Gastrointestinal regulatory peptides and their receptors. Curr Opin Endocrinol Diabetes Obes. 2014 Feb; 21(1):1-2. PMID: 24296463.
    View in: PubMed
  10. Rao S, Weber HC. New treatment targets for the management of irritable bowel syndrome. Curr Opin Endocrinol Diabetes Obes. 2014 Feb; 21(1):9-14. PMID: 24300740.
    View in: PubMed
  11. Weber HC. Medical treatment of neuroendocrine tumours. Curr Opin Endocrinol Diabetes Obes. 2013 Feb; 20(1):27-31. PMID: 23221494.
    View in: PubMed
  12. Qu X, Li M, Liu HJ, Xiang Y, Tan Y, Weber HC, Qin XQ. Role of bombesin receptor activated protein in the antigen presentation by human bronchial epithelial cells. J Cell Biochem. 2013 Jan; 114(1):238-44. PMID: 22930588.
    View in: PubMed
  13. Hermos JA, Altincatal A, Weber HC, Grotzinger K, Smoot KJ, Cho K, Gagnon DR, Lawler EV. Thrombocytopenia and bleeding in veterans with non-hepatitis C-related chronic liver disease. Dig Dis Sci. 2013 Feb; 58(2):562-73. PMID: 23010745.
    View in: PubMed
  14. Majumdar ID, Weber HC. Biology and pharmacology of bombesin receptor subtype-3. Curr Opin Endocrinol Diabetes Obes. 2012 Feb; 19(1):3-7. PMID: 22157398.
    View in: PubMed
  15. Weber HC. Gastrointestinal regulatory peptides. Curr Opin Endocrinol Diabetes Obes. 2012 Feb; 19(1):1-2. PMID: 22157408.
    View in: PubMed
  16. Majumdar ID, Weber HC. Appetite-modifying effects of bombesin receptor subtype-3 agonists. Handb Exp Pharmacol. 2012; (209):405-32. PMID: 22249826.
    View in: PubMed
  17. Qin X, Qu X, Coy D, Weber HC. A selective human bombesin receptor subtype-3 peptide agonist mediates CREB phosphorylation and transactivation. J Mol Neurosci. 2012 Jan; 46(1):88-99. PMID: 22127929.
    View in: PubMed
  18. Deb Majumdar I, Devanabanda A, Fox B, Schwartzman J, Cong H, Porco JA, Weber HC. Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro. Biochem Biophys Res Commun. 2011 Dec 16; 416(3-4):397-402. PMID: 22120630.
    View in: PubMed
  19. Majumdar ID, Weber HC. Biology of mammalian bombesin-like peptides and their receptors. Curr Opin Endocrinol Diabetes Obes. 2011 Feb; 18(1):68-74. PMID: 21042212.
    View in: PubMed
  20. Weber HC. Gastrointestinal regulatory peptides. Curr Opin Endocrinol Diabetes Obes. 2011 Feb; 18(1):33-4. PMID: 21178691.
    View in: PubMed
  21. Majumdar ID, Weber HC. Gastrointestinal regulatory peptides and their effects on fat tissue. Curr Opin Endocrinol Diabetes Obes. 2010 Feb; 17(1):51-6. PMID: 19855273.
    View in: PubMed
  22. Weber HC. Editorial overview: gastrointestinal regulatory peptides. Curr Opin Endocrinol Diabetes Obes. 2010 Feb; 17(1):31-2. PMID: 19996968.
    View in: PubMed
  23. Flicker MS, Weber HC. Endoscopic hemostasis in a case of bleeding from Zenker's diverticulum. Gastrointest Endosc. 2010 Apr; 71(4):869-71. PMID: 19922922.
    View in: PubMed
  24. Chinnappan D, Xiao D, Ratnasari A, Andry C, King TC, Weber HC. Transcription factor YY1 expression in human gastrointestinal cancer cells. Int J Oncol. 2009 May; 34(5):1417-23. PMID: 19360355.
    View in: PubMed
  25. Huang Q, Minor MA, Weber HC. Clinical challenges and images in GI. Diagnosis: Cavernous lymphangioma of the jejunum. Gastroenterology. 2009 Apr; 136(4):1170, 1465. PMID: 19254683.
    View in: PubMed
  26. Weber HC. Regulation and signaling of human bombesin receptors and their biological effects. Curr Opin Endocrinol Diabetes Obes. 2009 Feb; 16(1):66-71. PMID: 19115523.
    View in: PubMed
  27. Weber HC. Gastrointestinal regulatory peptides. Curr Opin Endocrinol Diabetes Obes. 2009 Feb; 16(1):45-6. PMID: 19104237.
    View in: PubMed
  28. Chinnappan D, Qu X, Xiao D, Ratnasari A, Weber HC. Human gastrin-releasing peptide receptor gene regulation requires transcription factor binding at two distinct CRE sites. Am J Physiol Gastrointest Liver Physiol. 2008 Jul; 295(1):G153-G162. PMID: 18483184.
    View in: PubMed
  29. Tan YR, Qin XQ, Xiang Y, Yang T, Qu F, Wang Y, Liu HJ, Weber HC. PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells. Biochem J. 2007 Jul 1; 405(1):131-7. PMID: 17355223.
    View in: PubMed
  30. Corleto VD, Severi C, Romano G, Tattoli I, Weber HC, Stridsberg M, Rindi G, Campanini N, Tomassoni F, Pagotto U, Coy DH, Jensen RT, Delle Fave G. Somatostatin receptor subtypes mediate contractility on human colonic smooth muscle cells. Neurogastroenterol Motil. 2006 Mar; 18(3):217-25. PMID: 16487413.
    View in: PubMed
  31. Xiao D, Chinnappan D, Pestell R, Albanese C, Weber HC. Bombesin regulates cyclin D1 expression through the early growth response protein Egr-1 in prostate cancer cells. Cancer Res. 2005 Nov 1; 65(21):9934-42. PMID: 16267018.
    View in: PubMed
  32. Qu X, Xiao D, Weber HC. Transcriptional activation of the human gastrin-releasing peptide receptor gene in gastrointestinal and prostatic epithelial cancer cells. J Mol Neurosci. 2004; 22(1-2):75-82. PMID: 14742912.
    View in: PubMed
  33. Xiao D, Qu X, Weber HC. Activation of extracellular signal-regulated kinase mediates bombesin-induced mitogenic responses in prostate cancer cells. Cell Signal. 2003 Oct; 15(10):945-53. PMID: 12873708.
    View in: PubMed
  34. Xiao D, Qu X, Weber HC. GRP receptor-mediated immediate early gene expression and transcription factor Elk-1 activation in prostate cancer cells. Regul Pept. 2002 Nov 15; 109(1-3):141-8. PMID: 12409226.
    View in: PubMed
  35. Qu X, Xiao D, Weber HC. Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells. FEBS Lett. 2002 Sep 11; 527(1-3):109-13. PMID: 12220644.
    View in: PubMed
  36. Harris PR, Weber HC, Wilcox CM, Jensen RT, Smith PD. Cytokine gene profile in gastric mucosa in Helicobacter pylori infection and Zollinger-Ellison syndrome. Am J Gastroenterol. 2002 Feb; 97(2):312-8. PMID: 11866267.
    View in: PubMed
  37. Stone C, Weber HC. Endoscopic removal of colonic lipomas. Am J Gastroenterol. 2001 Apr; 96(4):1295-7. PMID: 11316189.
    View in: PubMed
  38. Xiao D, Wang J, Hampton LL, Weber HC. The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter. Gene. 2001 Feb 7; 264(1):95-103. PMID: 11245983.
    View in: PubMed
  39. Weber HC, Walters J, Leyton J, Casibang M, Purdom S, Jensen RT, Coy DH, Ellis C, Clark G, Moody TW. A bombesin receptor subtype-3 peptide increases nuclear oncogene expression in a MEK-1 dependent manner in human lung cancer cells. Eur J Pharmacol. 2001 Jan 19; 412(1):13-20. PMID: 11166731.
    View in: PubMed
  40. Ryan RR, Weber HC, Mantey SA, Hou W, Hilburger ME, Pradhan TK, Coy DH, Jensen RT. Pharmacology and intracellular signaling mechanisms of the native human orphan receptor BRS-3 in lung cancer cells. J Pharmacol Exp Ther. 1998 Oct; 287(1):366-80. PMID: 9765358.
    View in: PubMed
  41. Ryan RR, Weber HC, Hou W, Sainz E, Mantey SA, Battey JF, Coy DH, Jensen RT. Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3. J Biol Chem. 1998 May 29; 273(22):13613-24. PMID: 9593699.
    View in: PubMed
  42. Weber HC, Hampton LL, Jensen RT, Battey JF. Structure and chromosomal localization of the mouse bombesin receptor subtype 3 gene. Gene. 1998 Apr 28; 211(1):125-31. PMID: 9573346.
    View in: PubMed
  43. Hampton LL, Ladenheim EE, Akeson M, Way JM, Weber HC, Sutliff VE, Jensen RT, Wine LJ, Arnheiter H, Battey JF. Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):3188-92. PMID: 9501238.
    View in: PubMed
  44. Pradhan TK, Katsuno T, Taylor JE, Kim SH, Ryan RR, Mantey SA, Donohue PJ, Weber HC, Sainz E, Battey JF, Coy DH, Jensen RT. Identification of a unique ligand which has high affinity for all four bombesin receptor subtypes. Eur J Pharmacol. 1998 Feb 19; 343(2-3):275-87. PMID: 9570477.
    View in: PubMed
  45. Marsh DJ, Dahia PL, Coulon V, Zheng Z, Dorion-Bonnet F, Call KM, Little R, Lin AY, Eeles RA, Goldstein AM, Hodgson SV, Richardson AL, Robinson BG, Weber HC, Longy M, Eng C. Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation. Genes Chromosomes Cancer. 1998 Jan; 21(1):61-9. PMID: 9443042.
    View in: PubMed
  46. Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT. Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors. J Biol Chem. 1997 Oct 10; 272(41):26062-71. PMID: 9325344.
    View in: PubMed
  47. Garcia LJ, Pradhan TK, Weber HC, Moody TW, Jensen RT. The gastrin-releasing peptide receptor is differentially coupled to adenylate cyclase and phospholipase C in different tissues. Biochim Biophys Acta. 1997 May 27; 1356(3):343-54. PMID: 9194577.
    View in: PubMed
  48. Stewart CA, Termanini B, Sutliff VE, Corleto VD, Weber HC, Gibril F, Jensen RT. Management of the Zollinger-Ellison syndrome in pregnancy. Am J Obstet Gynecol. 1997 Jan; 176(1 Pt 1):224-33. PMID: 9024119.
    View in: PubMed
  49. Weber HC, Venzon DJ, Jensen RT, Metz DC. Studies on the interrelation between Zollinger-Ellison syndrome, Helicobacter pylori, and proton pump inhibitor therapy. Gastroenterology. 1997 Jan; 112(1):84-91. PMID: 8978346.
    View in: PubMed
  50. Gibril F, Reynolds JC, Doppman JL, Chen CC, Venzon DJ, Termanini B, Weber HC, Stewart CA, Jensen RT. Somatostatin receptor scintigraphy: its sensitivity compared with that of other imaging methods in detecting primary and metastatic gastrinomas. A prospective study. Ann Intern Med. 1996 Jul 1; 125(1):26-34. PMID: 8644985.
    View in: PubMed
  51. Orbuch M, Venzon DJ, Lubensky IA, Weber HC, Gibril F, Jensen RT. Prolonged hypergastrinemia does not increase the frequency of colonic neoplasia in patients with Zollinger-Ellison syndrome. Dig Dis Sci. 1996 Mar; 41(3):604-13. PMID: 8617144.
    View in: PubMed
  52. Termanini B, Gibril F, Stewart CA, Weber HC, Jensen RT. A prospective study of the effectiveness of low dose omeprazole as initial therapy in Zollinger-Ellison syndrome. Aliment Pharmacol Ther. 1996 Feb; 10(1):61-71. PMID: 8871445.
    View in: PubMed
  53. Gibril F, Doppman JL, Chang R, Weber HC, Termanini B, Jensen RT. Metastatic gastrinomas: localization with selective arterial injection of secretin. Radiology. 1996 Jan; 198(1):77-84. PMID: 8539410.
    View in: PubMed
  54. Weber HC, Venzon DJ, Lin JT, Fishbein VA, Orbuch M, Strader DB, Gibril F, Metz DC, Fraker DL, Norton JA, et al. Determinants of metastatic rate and survival in patients with Zollinger-Ellison syndrome: a prospective long-term study. Gastroenterology. 1995 Jun; 108(6):1637-49. PMID: 7768367.
    View in: PubMed
  55. Weber HC, Orbuch M, Jensen RT. Diagnosis and management of Zollinger-Ellison syndrome. Semin Gastrointest Dis. 1995 Apr; 6(2):79-89. PMID: 7788286.
    View in: PubMed
  56. Metz DC, Weber HC, Orbuch M, Strader DB, Lubensky IA, Jensen RT. Helicobacter pylori infection. A reversible cause of hypergastrinemia and hyperchlorhydria which may mimic Zollinger-Ellison syndrome. Dig Dis Sci. 1995 Jan; 40(1):153-9. PMID: 7821103.
    View in: PubMed
  57. Arnold WS, Fraker DL, Alexander HR, Weber HC, Norton JA, Jensen RT. Apparent lymph node primary gastrinoma. Surgery. 1994 Dec; 116(6):1123-9; discussion 1129-30. PMID: 7985097.
    View in: PubMed
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