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Delitsikou V, Jarad G, Rajaram RD, Ino F, Rutkowski JM, Chen CD, Santos CXC, Scherer PE, Abraham CR, Shah AM, Feraille E, Miner JH, de Seigneux S. Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress. FASEB J. 2020 02; 34(2):2087-2104. PMID: 31907991
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Zeldich E, Chen CD, Boden E, Howat B, Nasse JS, Zeldich D, Lambert AG, Yuste A, Cherry JD, Mathias RM, Ma Q, Lau NC, McKee AC, Hatzipetros T, Abraham CR. Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS. J Mol Neurosci. 2019 Oct; 69(2):264-285.View Related Profiles. PMID: 31250273; PMCID: PMC7008951; DOI: 10.1007/s12031-019-01356-2;
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McGrath ER, Himali JJ, Levy D, Conner SC, Pase MP, Abraham CR, Courchesne P, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study. PLoS One. 2019; 14(3):e0213321.View Related Profiles. PMID: 30830941; PMCID: PMC6398923; DOI: 10.1371/journal.pone.0213321;
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Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-ß Protein Precursor Processing Modulators Lower Amyloid-ß Peptide Levels via cKit Signaling. J Alzheimers Dis. 2019; 67(3):1089-1106.View Related Profiles. PMID: 30776010; PMCID: PMC6474660; DOI: 10.3233/JAD-180923;
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Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. J Neuroimmune Pharmacol. 2018 06; 13(2):254-264.View Related Profiles. PMID: 29516269; PMCID: PMC5928172; DOI: 10.1007/s11481-018-9781-x;
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Dubal DB, Zhu L, Sanchez PE, Worden K, Broestl L, Johnson E, Ho K, Yu GQ, Kim D, Betourne A, Kuro-O M, Masliah E, Abraham CR, Mucke L. Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. J Neurosci. 2015 Feb 11; 35(6):2358-71. PMID: 25673831; PMCID: PMC4323521; DOI: 10.1523/JNEUROSCI.5791-12.2015;
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Chen CD, Tung TY, Liang J, Zeldich E, Tucker Zhou TB, Turk BE, Abraham CR. Identification of cleavage sites leading to the shed form of the anti-aging protein klotho. Biochemistry. 2014 Sep 2; 53(34):5579-87.View Related Profiles. PMID: 25110992; PMCID: PMC4151695; DOI: 10.1021/bi500409n;
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Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Kim JW, Buxbaum JD, Mayeux R, Ikezu T, Abraham CR, Farrer LA. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Ann Neurol. 2014 Sep; 76(3):379-92.View Related Profiles. PMID: 25043464; PMCID: PMC4830273; DOI: 10.1002/ana.24219;
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Zeldich E, Chen CD, Colvin TA, Bove-Fenderson EA, Liang J, Tucker Zhou TB, Harris DA, Abraham CR. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 2014 Aug 29; 289(35):24700-15.View Related Profiles. PMID: 25037225; PMCID: PMC4148892; DOI: 10.1074/jbc.M114.567321;
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Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, Miller BL, Mucke L. Life extension factor klotho enhances cognition. Cell Rep. 2014 May 22; 7(4):1065-76. PMID: 24813892; PMCID: PMC4176932; DOI: 10.1016/j.celrep.2014.03.076;
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Tucker Zhou TB, King GD, Chen C, Abraham CR. Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk. J Biol Chem. 2013 Dec 20; 288(51):36302-11. PMID: 24217253; PMCID: PMC3868745; DOI: 10.1074/jbc.M113.490052;
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So PP, Khodr CE, Chen CD, Abraham CR. Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants. Am J Neurodegener Dis. 2013; 2(1):15-28.View Related Profiles. PMID: 23515184; PMCID: PMC3601467
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Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci. 2013 Jan 30; 33(5):1927-39.View Related Profiles. PMID: 23365232; PMCID: PMC3711388; DOI: 10.1523/JNEUROSCI.2080-12.2013;
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McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013 Jan; 136(Pt 1):43-64.View Related Profiles. PMID: 23208308; PMCID: PMC3624697; DOI: 10.1093/brain/aws307;
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So PP, Zeldich E, Seyb KI, Huang MM, Concannon JB, King GD, Chen CD, Cuny GD, Glicksman MA, Abraham CR. Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-ß precursor protein dimerization. Am J Neurodegener Dis. 2012; 1(1):75-87.View Related Profiles. PMID: 22822474; PMCID: PMC3560454
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King GD, Chen C, Huang MM, Zeldich E, Brazee PL, Schuman ER, Robin M, Cuny GD, Glicksman MA, Abraham CR. Identification of novel small molecules that elevate Klotho expression. Biochem J. 2012 Jan 1; 441(1):453-61.View Related Profiles. PMID: 21939436; PMCID: PMC3677209; DOI: 10.1042/BJ20101909;
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Abraham CR, Nalge MW. Handbook of Proteolytic Enzymes. Acylaminoacyl-peptidase. 2011.
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Abraham CR. The Handbook of Alzheimer’s Disease and Other Dementias; Edited by Andrew E. Budson, Neil W. Kowall. Amyloid beta peptide and the Amyloid cascade hypothesis. Blackwell Publishing Ltd. 2011.
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Zerbinatti CV, Cordy JM, Chen CD, Guillily M, Suon S, Ray WJ, Seabrook GR, Abraham CR, Wolozin B. Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein. Mol Neurodegener. 2008; 3:5.View Related Profiles. PMID: 18348724; PMCID: PMC2323375; DOI: 10.1186/1750-1326-3-5;
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Duce JA, Podvin S, Hollander W, Kipling D, Rosene DL, Abraham CR. Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. Glia. 2008 Jan 1; 56(1):106-17.View Related Profiles. PMID: 17963266
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Hinman JD, Chen CD, Oh SY, Hollander W, Abraham CR. Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts. Glia. 2008 Jan 1; 56(1):118-33.View Related Profiles. PMID: 17963267
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Hinman JD, Abraham CR. What's behind the decline? The role of white matter in brain aging. Neurochem Res. 2007 Dec; 32(12):2023-31. PMID: 17447140
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Yamin R, Bagchi S, Hildebrant R, Scaloni A, Widom RL, Abraham CR. Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptide. J Neurochem. 2007 Jan; 100(2):458-67. PMID: 17241160
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Chen CD, Oh SY, Hinman JD, Abraham CR. Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation. J Neurochem. 2006 Apr; 97(1):30-43.View Related Profiles. PMID: 16515557
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Oh SY, Ellenstein A, Chen CD, Hinman JD, Berg EA, Costello CE, Yamin R, Neve RL, Abraham CR. Amyloid precursor protein interacts with notch receptors. J Neurosci Res. 2005 Oct 1; 82(1):32-42.View Related Profiles. PMID: 16118793
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Duce JA, Hollander W, Jaffe R, Abraham CR. Activation of early components of complement targets myelin and oligodendrocytes in the aged rhesus monkey brain. Neurobiol Aging. 2006 Apr; 27(4):633-44. PMID: 15992964
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Hinman JD, Duce JA, Siman RA, Hollander W, Abraham CR. Activation of calpain-1 in myelin and microglia in the white matter of the aged rhesus monkey. J Neurochem. 2004 Apr; 89(2):430-41. PMID: 15056286
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Abraham CR. Elsevier’s Encyclopedia of Neuroscience; Ed. George Adelman and Barry Smith. The amyloid precursor protein and presenilins. 2004.
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York IA, Mo AX, Lemerise K, Zeng W, Shen Y, Abraham CR, Saric T, Goldberg AL, Rock KL. The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. Immunity. 2003 Mar; 18(3):429-40. PMID: 12648459
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Sloane JA, Hinman JD, Lubonia M, Hollander W, Abraham CR. Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey. J Neurochem. 2003 Jan; 84(1):157-68. PMID: 12485412
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Abraham CR. Reactive astrocytes and alpha1-antichymotrypsin in Alzheimer's disease. Neurobiol Aging. 2001 Nov-Dec; 22(6):931-6. PMID: 11755001
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Abraham CR and Slot F. Role of Proteases in the Pathophysiology of Neurodegenerative Diseases; Ed. Lajta and Banik Kluwer. Metalloendopeptidase EC 3.4.24.15 in Neurodegeneration. Academic/Plenum Publishers. New York. 2001; 101-116.
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Mucke L, Yu GQ, McConlogue L, Rockenstein EM, Abraham CR, Masliah E. Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice. Am J Pathol. 2000 Dec; 157(6):2003-10. PMID: 11106573; PMCID: PMC1885780
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Sloane JA, Hollander W, Rosene DL, Moss MB, Kemper T, Abraham CR. Astrocytic hypertrophy and altered GFAP degradation with age in subcortical white matter of the rhesus monkey. Brain Res. 2000 Apr 17; 862(1-2):1-10.View Related Profiles. PMID: 10799662
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Abraham CR. Amyloid beta peptide: a century of discoveries. Amyloid. 2000 Mar; 7(1):7-9. PMID: 10842695
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Abraham CR, McGraw WT, Slot F, Yamin R. Alpha 1-antichymotrypsin inhibits A beta degradation in vitro and in vivo. Ann N Y Acad Sci. 2000; 920:245-8. PMID: 11193158
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Sloane JA, Hollander W, Moss MB, Rosene DL, Abraham CR. Increased microglial activation and protein nitration in white matter of the aging monkey. Neurobiol Aging. 1999 Jul-Aug; 20(4):395-405.View Related Profiles. PMID: 10604432
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Yamin R, Malgeri EG, Sloane JA, McGraw WT, Abraham CR. Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation. J Biol Chem. 1999 Jun 25; 274(26):18777-84. PMID: 10373494
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Abraham CR, Marshall DC, Tibbles HE, Otto K, Long HJ, Billingslea AM, Hastey R, Johnson R, Fine RE, Smith SJ, Simons ER, Davies TA. Platelets and DAMI megakaryocytes possess beta-secretase-like activity. J Lab Clin Med. 1999 May; 133(5):507-15.View Related Profiles. PMID: 10235134
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Farrer LA, Abraham CR, Haines JL, Rogaeva EA, Song Y, McGraw WT, Brindle N, Premkumar S, Scott WK, Yamaoka LH, Saunders AM, Roses AD, Auerbach SA, Sorbi S, Duara R, Pericak-Vance MA, St George-Hyslop PH. Association between bleomycin hydrolase and Alzheimer's disease in caucasians. Ann Neurol. 1998 Nov; 44(5):808-11.View Related Profiles. PMID: 9818937
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Marshall DC, Wyss-Coray T, Abraham CR. Induction of matrix metalloproteinase-2 in human immunodeficiency virus-1 glycoprotein 120 transgenic mouse brains. Neurosci Lett. 1998 Sep 25; 254(2):97-100. PMID: 9779929
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Simons ER, Marshall DC, Long HJ, Otto K, Billingslea A, Tibbles H, Wells J, Eisenhauer P, Fine RE, Cribbs DH, Davies TA, Abraham CR. Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases. Amyloid. 1998 Sep; 5(3):153-62.View Related Profiles. PMID: 9818052
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Meckelein B, Marshall DC, Conn KJ, Pietropaolo M, Van Nostrand W, Abraham CR. Identification of a novel serine protease-like molecule in human brain. Brain Res Mol Brain Res. 1998 Apr; 55(2):181-97. PMID: 9582421
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Slot F, Olsen AL, Rao N, Abraham CR. Localization of human endopeptidase E.C.3.4.24.15 (THOP1) at 19p13.3. Alzheimer's reports. 1998; 1:327-331.
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Sloane JA, Pietropaolo MF, Rosene DL, Moss MB, Peters A, Kemper T, Abraham CR. Lack of correlation between plaque burden and cognition in the aged monkey. Acta Neuropathol. 1997 Nov; 94(5):471-8.View Related Profiles. PMID: 9386780
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Aleshkov S, Abraham CR, Zannis VI. Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease. Biochemistry. 1997 Aug 26; 36(34):10571-80.View Related Profiles. PMID: 9265639
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Masliah E, Westland CE, Rockenstein EM, Abraham CR, Mallory M, Veinberg I, Sheldon E, Mucke L. Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience. 1997 May; 78(1):135-46. PMID: 9135095
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Liang JS, Sloane JA, Wells JM, Abraham CR, Fine RE, Sipe JD. Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain. Neurosci Lett. 1997 Apr 4; 225(2):73-6.View Related Profiles. PMID: 9147377
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Fine RE, Abraham CR. b amyloid precursor protein is a key sorting and targeting receptor for neuropeptidases. Amyloid. 1997; 4:233-239.
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Kanemaru K, Meckelein B, Marshall DC, Sipe JD, Abraham CR. Synthesis and secretion of active alpha 1-antichymotrypsin by murine primary astrocytes. Neurobiol Aging. 1996 Sep-Oct; 17(5):767-71. PMID: 8892350
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Peters A, Rosene DL, Moss MB, Kemper TL, Abraham CR, Tigges J, Albert MS. Neurobiological bases of age-related cognitive decline in the rhesus monkey. J Neuropathol Exp Neurol. 1996 Aug; 55(8):861-74.View Related Profiles. PMID: 8759775
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Conn KJ, Pietropaolo M, Ju ST, Abraham CR. Monoclonal antibodies against the human metalloprotease EC 3.4.24.15 label neurofibrillary tangles in Alzheimer's disease brain. J Neurochem. 1996 May; 66(5):2011-8. PMID: 8780030
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Amaratunga A, Abraham CR, Edwards RB, Sandell JH, Schreiber BM, Fine RE. Apolipoprotein E is synthesized in the retina by Müller glial cells, secreted into the vitreous, and rapidly transported into the optic nerve by retinal ganglion cells. J Biol Chem. 1996 Mar 8; 271(10):5628-32.View Related Profiles. PMID: 8621425
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Liang JS, Fine RE, Abraham CR, Sipe JD. The fibril forming region of the beta-amyloid precursor differs from that of the amyloid A precursor in its interaction with lipids. Biochem Biophys Res Commun. 1996 Feb 27; 219(3):962-7.View Related Profiles. PMID: 8645287
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Chang T, Abraham CR. A novel brain cysteine protease forms an SDS stable complex with the beta-amyloid precursor protein. Ann N Y Acad Sci. 1996 Jan 17; 777:183-8. PMID: 8624082
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Mucke L, Abraham CR, Masliah E. Neurotrophic and neuroprotective effects of hAPP in transgenic mice. Ann N Y Acad Sci. 1996 Jan 17; 777:82-8. PMID: 8624131
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Meckelein B, de Silva HA, Roses AD, Rao PN, Pettenati MJ, Xu PT, Hodge R, Glucksman MJ, Abraham CR. Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus. Genomics. 1996 Jan 15; 31(2):246-9. PMID: 8824811
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Farrer LA, Abraham CR, Volicer L, Foley EJ, Kowall NW, McKee AC, Wells JM. Allele epsilon 4 of apolipoprotein E shows a dose effect on age at onset of Pick disease. Exp Neurol. 1995 Dec; 136(2):162-70.View Related Profiles. PMID: 7498406
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Mucke L, Abraham CR, Ruppe MD, Rockenstein EM, Toggas SM, Mallory M, Alford M, Masliah E. Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein. J Exp Med. 1995 Apr 1; 181(4):1551-6. PMID: 7699335; PMCID: PMC2191956
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Koch D, Abraham CR. [Alzheimer's disease and the significance of amyloid-beta protein in its pathogenesis]. Harefuah. 1995 Feb 1; 128(3):156-9. PMID: 7759006
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Mucke L, Masliah E, Johnson WB, Ruppe MD, Alford M, Rockenstein EM, Forss-Petter S, Pietropaolo M, Mallory M, Abraham CR. Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice. Brain Res. 1994 Dec 15; 666(2):151-67. PMID: 7882025
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Toggas SM, Masliah E, Rockenstein EM, Rall GF, Abraham CR, Mucke L. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature. 1994 Jan 13; 367(6459):188-93. PMID: 8114918
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Papastoitsis G, Siman R, Scott R, Abraham CR. Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. Biochemistry. 1994 Jan 11; 33(1):192-9. PMID: 8286339
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Conn, K.J., Papastoitsis G, Meckelein B, Abraham CR. Identification of full length ß-amyloid precursor protein in human neuronal and non-neuronal cell culture supernatant: A possible extracellular source for the generation of Aß. Amyloid. 1994; 1:232-239.
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Stone PJ, Campistol JM, Abraham CR, Rodgers O, Shirahama T, Skinner M. Neutrophil proteases associated with amyloid fibrils. Biochem Biophys Res Commun. 1993 Nov 30; 197(1):130-6.View Related Profiles. PMID: 8250917
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Razzaboni BL, Meckelein B, Abraham CR. Purification and cloning of monkey proteases involved in the processing of the beta-amyloid precursor protein. Neurobiol Aging. 1993 Nov-Dec; 14(6):677-9. PMID: 8295685
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Campbell IL, Abraham CR, Masliah E, Kemper P, Inglis JD, Oldstone MB, Mucke L. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc Natl Acad Sci U S A. 1993 Nov 1; 90(21):10061-5. PMID: 7694279; PMCID: PMC47713
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Abraham CR, Kanemaru K, Mucke L. Expression of cathepsin G-like and alpha 1-antichymotrypsin-like proteins in reactive astrocytes. Brain Res. 1993 Sep 10; 621(2):222-32. PMID: 8242336
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Morin PJ, Abraham CR, Amaratunga A, Johnson RJ, Huber G, Sandell JH, Fine RE. Amyloid precursor protein is synthesized by retinal ganglion cells, rapidly transported to the optic nerve plasma membrane and nerve terminals, and metabolized. J Neurochem. 1993 Aug; 61(2):464-73.View Related Profiles. PMID: 7687653
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Fraser PE, Nguyen JT, McLachlan DR, Abraham CR, Kirschner DA. Alpha 1-antichymotrypsin binding to Alzheimer A beta peptides is sequence specific and induces fibril disaggregation in vitro. J Neurochem. 1993 Jul; 61(1):298-305. PMID: 8515277
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Fraser PE, Kirschner DA, Nguyen JT, Abraham CR, McLachlan DR. Proceedings of the VIIth International Symposium on Amyloidosis (Ed. R. Kisilevsky). Binding of sulphated proteins and a1-antichymotrypsin to Alzheimer ßA4: Different actions of amyloid associated proteins. Parthenon Publishing. Pearl River, NY. 1993; 504-506.
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Abraham CR, Razzaboni BL. Molecular Diagnostics: Research Towards Application. The molecular biology of neurodegenerative diseases. Blackwell Scientific Publications Ltd. Oxford, England. 1993.
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Abraham CR, Papastoitsis G, Razzaboni BL, Kanemaru K, Pietropaolo M, Conn KJ, Meckelein B. Studies on brain proteases capable of degrading the ß amyloid precursor protein. Proteolysis and Protein Turnover. 1993; 197-202.
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Papastoitsis G, Conn K-J, Siman R, Scott R, Abraham CR. Proceedings of the VIIth International Symposium on Amyloidosis (Ed. R. Kisilevsky). Identification of a metalloprotease from Alzheimer's disease brain able of cleaving the met-asp bond and of degrading human APP. Parthenon Publishing. Pearl River, NY. 1993; 332-334.
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Abraham CR, Razzaboni BL, Papastoitsis G, Picard E, Kanemaru K, Meckelein B, Mucke L. Purification and cloning of brain proteases capable of degrading the beta-amyloid precursor protein. Ann N Y Acad Sci. 1992 Dec 31; 674:174-9. PMID: 1288362
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Campistol JM, Shirahama T, Abraham CR, Rodgers OG, Solé M, Cohen AS, Skinner M. Demonstration of plasma proteinase inhibitors in beta 2-microglobulin amyloid deposits. Kidney Int. 1992 Oct; 42(4):915-23.View Related Profiles. PMID: 1280700
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Razzaboni BL, Papastoitsis G, Koo EH, Abraham CR. A calcium-stimulated serine protease from monkey brain degrades the beta-amyloid precursor protein. Brain Res. 1992 Sep 4; 589(2):207-16. PMID: 1393590
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Abraham CR. The role of the acute-phase protein alpha 1-antichymotrypsin in brain dysfunction and injury. Res Immunol. 1992 Jul-Aug; 143(6):631-6. PMID: 1455055
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Koo EH, Abraham CR, Potter H, Cork LC, Price DL. Developmental expression of alpha 1-antichymotrypsin in brain may be related to astrogliosis. Neurobiol Aging. 1991 Sep-Oct; 12(5):495-501. PMID: 1837594
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Richards SJ, Waters JJ, Beyreuther K, Masters CL, Wischik CM, Sparkman DR, White CL, Abraham CR, Dunnett SB. Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology. EMBO J. 1991 Feb; 10(2):297-303. PMID: 1899372; PMCID: PMC452646
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Abraham CR, Driscoll J, Potter H, Van Nostrand WE, Tempst P. A calcium-activated protease from Alzheimer's disease brain cleaves at the N-terminus of the amyloid beta-protein. Biochem Biophys Res Commun. 1991 Jan 31; 174(2):790-6. PMID: 1993072
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Abraham CR, Razzaboni BL, Sisodia SS, Koo EH, Price DL, Van Nostrand WE, Papastoitsis G. Studies on the proteolytic degradation of the beta-protein precursor by proteases purified from Alzheimer's disease brain. Ann N Y Acad Sci. 1991; 640:161-5. PMID: 1776735
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Shirahama T, Abraham CR, Ju S-T, Miura K, Cohen AS, Kisilevsky. Amyloid and Amyloidosis, edited by Natvig, J. et al. Isolation of a 16KD fraction with extremely high AEF activity. Kleuwer Academic Publishers. The Netherlands. 1991; 288-291.
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Potter H, Abraham CR, Dressler DH. Alzheimer's Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies; edited by K. Iqbal, D.R.C. McLachlan, B. Winblad and H. M. Wisniewski. The Alzheimer amyloid components a1 antichymotrypsin and ß-protein from a stable complex in vitro. 1991; 275-279.
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Abraham CR, Razzaboni BL, Ben-Meir A, Papastoitsis G. Amyloid and Amyloidosis, edited by Natvig, J.B. et al. Proteolytic processing of ß-amyloid protein-related synthetic peptides and the ß-protein precursor by a protease purified from Alzheimer's disease brain. Kluwer Academic Publishers. The Netherlands. 1991; 718-721.
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Abraham CR, Bem Meir A, Tempst P. Facile and sensitive assay for monitoring proteolytic activities with defined specificities: studies on amyloid beta-protein processing in Alzheimer's disease. Pept Res. 1990 Sep-Oct; 3(5):211-5. PMID: 2134064
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Abraham CR, Shirahama T, Potter H. Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin. Neurobiol Aging. 1990 Mar-Apr; 11(2):123-9. PMID: 2190106
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Abraham CR, Potter H. Serine Proteases and Their Serpin Inhibitors in the Nervous System, Editor: B. Festoff. The serpin a1-antichymotrypsin in brain aging and diseases of the nervous system. 1990; 321-326.
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Abraham CR. Molecular Biology and Genetics of Alzheimer's Disease, Editors: Miyatake, T., Selkoe, D.J. Ihara, Y. A novel calcium-activated protease from brain cleaves ß-protein-precursor-related synthetic peptides and is inhibited by a1-antichymotrypsin and protease nexin 2. 1990; 159-166.
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Pasternack JM, Abraham CR, Van Dyke BJ, Potter H, Younkin SG. Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA. Am J Pathol. 1989 Nov; 135(5):827-34. PMID: 2817081; PMCID: PMC1880107
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Abraham CR. Potential roles of protease inhibitors in Alzheimer's disease. Neurobiol Aging. 1989 Sep-Oct; 10(5):463-5; discussion 477-8. PMID: 2682323
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Selkoe DJ, Duffy LK, Nukina N, Podlisny MB, Abraham CR, Kosik KS. Familial Alzheimer's Disease: Molecular Genetics and Clinical Perspectives; Blass et al (eds.). Molecular pathology of intra- and extraneuronal filaments in brain aging and Alzheimer's disease. Marcel Dekker. New York. 1989; 137-153.
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Abraham CR, Potter H. Alpha 1-antichymotrypsin in brain aging and disease. Prog Clin Biol Res. 1989; 317:1037-48. PMID: 2513582
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Abraham CR, Potter H. The protease inhibitor, alpha 1-antichymotrypsin, is a component of the brain amyloid deposits in normal aging and Alzheimer's disease. Ann Med. 1989; 21(2):77-81. PMID: 2669847
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Potter H, Abraham CR. Proceedings of the International Symposium on Biomedical Advances in Aging, ed. A.C. Goldstein. a1-antichymotrypsin: The role of proteases and their inhibitors in the amyloid deposition of Alzheimer's disease and normal brain aging. Plenum Press. 1989; 75-88.
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Abraham CR, Potter H. Alzheimer's disease: Recent advances in understanding the brain amyloid deposits. Biotechnology. 1989; 7:147-153.
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Abraham CR, Selkoe DJ, Potter H, Price DL, Cork LC. Alpha 1-antichymotrypsin is present together with the beta-protein in monkey brain amyloid deposits. Neuroscience. 1989; 32(3):715-20. PMID: 2689908
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Abraham CR, Selkoe DJ, Potter H. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell. 1988 Feb 26; 52(4):487-501. PMID: 3257719
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Abraham CR, Selkoe DJ, Potter H. Amyloid and Amyloidosis; Eds. T. Isobe, S. Araki, S. Kito and E. Tsubura. a1-antichymotrypsin, a serine protease inhibitor, is a component of amyloid deposits on Alzheimer's disease brain. Plenum Press. 1988; 543-548.
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Duffy LK, Abraham CR, Berman-Podlisny M, Walsh RL, Selkoe DJ. HPLC analysis of proteins from Alzheimer's disease paired helical filaments. Ann. N.Y. Acad. Sci. 1987; 494:369-372.
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Selkoe DJ, Abraham CR, Podlisny MB, Duffy LK. Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. J Neurochem. 1986 Jun; 46(6):1820-34. PMID: 3517233
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Selkoe DJ, Abraham CR. Isolation of paired helical filaments and amyloid fibers from human brain. Methods Enzymol. 1986; 134:388-404. PMID: 3821571
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Selkoe, DJ, Abraham CR, Rasool CG. Alzheimer's and Parkinson's Disease; A. Fisher, et al (eds.). Molecular properties of paired helical filaments and senile plaque amyloid fibers in Alzheimer's disease. Plenum Publishing Corp. New York. 1986; 37-42.
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Kirschner DA, Abraham C, Selkoe DJ. X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation. Proc Natl Acad Sci U S A. 1986 Jan; 83(2):503-7. PMID: 3455785; PMCID: PMC322888
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Selkoe DJ, Abraham CR. Amyloidosis; G.G. Glenner, et al, (eds.). Biochemical and structural studies of paired helical filaments and senile plaque amyloid in Alzheimer's disease. Plenum Publishing Corp. New York. 1986; 709-715.
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Selkoe DJ, Abraham C, Rasool CG, McCluskey A, Kosik KS, Duffy LK. Paired helical filaments in human neurons: relationship to neurofilaments. Ann N Y Acad Sci. 1985; 455:583-96. PMID: 3936387
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Selkoe DJ, Abraham CR, Rasool CG, McCluskey AH, Duffy LK. Intermediate Filaments. Ann. N.Y. Acad. Sci; E. Wang, et al. (eds.). Production and characterization of monoclonal antibodies to Alzheimer paired helical filaments. 1985; 455:774-778.
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Kosik KS, Duffy LK, Dowling MM, Abraham C, McCluskey A, Selkoe DJ. Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles. Proc Natl Acad Sci U S A. 1984 Dec; 81(24):7941-5. PMID: 6083566; PMCID: PMC392269
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Rasool CG, Abraham C, Anderton BH, Haugh M, Kahn J, Selkoe DJ. Alzheimer's disease: immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies. Brain Res. 1984 Sep 24; 310(2):249-60. PMID: 6207891
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Kosik KS, Ihara Y, Abraham CR, Rasool CG, McCluskey AH, Selkoe DJ. Comparative Pathobiology of Major Age-Related Diseases: Current Status and Research Frontiers. Neurochemical studies of Alzheimer-type neurofibrillary degeneration and a related experimental model. Alan R. Liss, Inc. New York. 1984; 373-384.
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Ihara Y, Abraham C, Selkoe DJ. Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins. Nature. 1983 Aug 25-31; 304(5928):727-30. PMID: 6350889
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Selkoe DJ, Ihara Y, Abraham CR, Rasool CG, McCluskey AH. Biological Aspects of Alzheimer's Disease (Banbury Report 15); Katzman, R. (ed.). Biochemical and immunocytochemical studies of Alzheimer paired helical filaments. Cold Spring Harbor Laboratory. New York. 1983; 125-134.
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Selkoe DJ, Abraham C, Ihara Y. Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers. Proc Natl Acad Sci U S A. 1982 Oct; 79(19):6070-4. PMID: 6136967; PMCID: PMC347054
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Selkoe DJ, Salazar FJ, Abraham C, Kosik KS. Huntington's disease: changes in striatal proteins reflect astrocytic gliosis. Brain Res. 1982 Aug 5; 245(1):117-25. PMID: 6214299
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Gaffin SL, Grinberg Z, Abraham C, Birkhan J, Shechter Y. Protection against hemorrhagic shock in the cat by human plasma containing endotoxin-specific antibodies. J Surg Res. 1981 Jul; 31(1):18-21. PMID: 7253637
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Gaffin SL, Abraham C. Hemoperfusion, Kidney and Liver Supports and Detoxification; Seidman S, Chang G (eds.). Uptake of endotoxin by endotoxin-specific membranes. Hemisphere Publ. Washington DC. 1980; 379-388.
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Gershon H, Merhav S, Abraham C. T-cell division and aging. Mech Ageing Dev. 1979 Jan; 9(1-2):27-38. PMID: 155760
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Gaffin SL, Abraham CR. Uptake of endotoxin by endotoxin-specific membranes. Israel J. Med. Sci. 1979; 15:622.
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Abraham C, Tal Y, Gershon H. Reduced in vitro response to concanavalin A and lipopolysaccharide in senescent mice: a function of reduced number of responding cells. Eur J Immunol. 1977 May; 7(5):301-4. PMID: 301478; DOI: 10.1002/eji.1830070512;
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Anikster J, Abraham CR, Greenberger Y, Wahl I. A contribution to the taxonomy of Puccinia brown leaf rust of barley in Israel. Israel J. Botany. 1971; 20:12.
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Abraham CR. Pectic enzymes in lemon peel infected by Geotrichum candidum. 1969.