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Last Name

James Panek, PhD

TitleSamour Family Professor in Organic Chemistry
InstitutionBoston University College of Arts and Sciences
DepartmentChemistry
Address24 Cummington Mall
Boston MA 02215
Phone(617) 353-2484
Fax(617) 353-6466
 Research Expertise & Professional Interests
Research activities in the Panek Group emphasize the area of synthetic organic chemistry, in particular the induction of chirality. The problems under study reflect their general interest in the synthesis of new reagents and development of new reaction methods. Ongoing studies in the area of natural product synthesis generate a complementary research effort. In the synthesis of complex organic molecules, new research methods are employed or developed to carry out the defined objectives. They are also affiliated with the Center for Molecular Discovery.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Allen EE, Zhu C, Panek JS, Schaus SE. Multicomponent Condensation Reactions via ortho-Quinone Methides. Org Lett. 2017 Apr 07; 19(7):1878-1881. PMID: 28357870.
    View in: PubMed
  2. Cai B, Evans RW, Wu J, Panek JS. Total Synthesis of Nuclear Factor of Activated T-Cells-68 (NFAT-68): Sequential Use of Chiral Allenylsilane and Titanium Alkoxide-Mediated Reductive Coupling Bond Construction. Org Lett. 2016 Sep 02; 18(17):4304-7. PMID: 27513364.
    View in: PubMed
  3. Cai B, Panek JS, Amar S. Convergent Synthesis of Novel Muramyl Dipeptide Analogues: Inhibition of Porphyromonas gingivalis-Induced Pro-inflammatory Effects by High Doses of Muramyl Dipeptide. J Med Chem. 2016 Jul 28; 59(14):6878-90. PMID: 27353235.
    View in: PubMed
  4. Barbato KS, Luan Y, Ramella D, Panek JS, Schaus SE. Enantioselective Multicomponent Condensation Reactions of Phenols, Aldehydes, and Boronates Catalyzed by Chiral Biphenols. Org Lett. 2015 Dec 4; 17(23):5812-5. PMID: 26576776.
    View in: PubMed
  5. Lee J, Panek JS. Total synthesis of (+)-isatisine a: application of a silicon-directed mukaiyama-type [3 + 2]-annulation. J Org Chem. 2015 Mar 20; 80(6):2959-71. PMID: 25739011.
    View in: PubMed
  6. Lee J, Panek JS. Synthesis of isochromene-type scaffolds via single-flask Diels-Alder-[4 + 2]-annulation sequence of a silyl-substituted diene with menadione. Org Lett. 2014 Jun 20; 16(12):3320-3. PMID: 24918110.
    View in: PubMed
  7. Brawn RA, Zhu K, Panek JS. Rhodium(II)-catalyzed alkyne amination of homopropargylic sulfamate esters: stereoselective synthesis of functionalized norcaradienes by arene cyclopropanation. Org Lett. 2014 Jan 3; 16(1):74-7. PMID: 24328560.
    View in: PubMed
  8. Wu J, Pu Y, Panek JS. Divergent synthesis of functionalized carbocycles through organosilane-directed asymmetric alkyne-alkene reductive coupling and annulation sequence. J Am Chem Soc. 2012 Nov 7; 134(44):18440-6. PMID: 23057751.
    View in: PubMed
  9. Wu J, Zhu KC, Yuan PW, Panek JS. Bifunctional homoallylic carbamates from chiral silane additions to in situ generated N-acyl iminium ions. Org Lett. 2012 Jul 20; 14(14):3624-7. PMID: 22738355.
    View in: PubMed
  10. Wu J, Panek JS. Total synthesis of (-)-virginiamycin M2: application of crotylsilanes accessed by enantioselective Rh(II) or Cu(I) promoted carbenoid Si-H insertion. J Org Chem. 2011 Dec 16; 76(24):9900-18. PMID: 22070230.
    View in: PubMed
  11. Zhu K, Panek JS. Total synthesis of (+)-SCH 351448. Org Lett. 2011 Sep 2; 13(17):4652-5. PMID: 21834568.
    View in: PubMed
  12. Wu J, Becerril J, Lian Y, Davies HM, Porco JA, Panek JS. Sequential transformations to access polycyclic chemotypes: asymmetric crotylation and metal carbenoid reactions. Angew Chem Int Ed Engl. 2011 Jun 20; 50(26):5938-42. PMID: 21560214.
    View in: PubMed
  13. Lee J, Panek JS. Total synthesis of (+)-isatisine A. Org Lett. 2011 Feb 4; 13(3):502-5. PMID: 21188973.
    View in: PubMed
  14. Brawn RA, Panek JS. Stereoselective C-glycosidations with achiral and enantioenriched allenylsilanes. Org Lett. 2010 Oct 15; 12(20):4624-7. PMID: 20839812.
    View in: PubMed
  15. Wu J, Panek JS. Total synthesis of (-)-virginiamycin M2. Angew Chem Int Ed Engl. 2010 Aug 16; 49(35):6165-8. PMID: 20648503.
    View in: PubMed
  16. Wu J, Chen Y, Panek JS. Vinylogous aldol products from chiral crotylsilanes obtained by enantioselective Rh(II) and Cu(I) carbenoid Si-H insertion. Org Lett. 2010 May 7; 12(9):2112-5. PMID: 20387893.
    View in: PubMed
  17. Wrona IE, Gozman A, Taldone T, Chiosis G, Panek JS. Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90. J Org Chem. 2010 May 7; 75(9):2820-35. PMID: 20392070.
    View in: PubMed
  18. Brawn RA, Welzel M, Lowe JT, Panek JS. Regioselective intramolecular dipolar cycloaddition of azides and unsymmetrical alkynes. Org Lett. 2010 Jan 15; 12(2):336-9. PMID: 20017521.
    View in: PubMed
  19. Lee J, Panek JS. Total synthesis of brevisamide. Org Lett. 2009 Oct 1; 11(19):4390-3. PMID: 19736917.
    View in: PubMed
  20. Brawn RA, Panek JS. Synthesis of enantioenriched homopropargylic sulfonamides by a three component reaction of aldehydes, sulfonamides, and chiral allenylsilanes. Org Lett. 2009 Oct 1; 11(19):4362-5. PMID: 19775184.
    View in: PubMed
  21. Zhang Y, Panek JS. Stereocontrolled synthesis of spirooxindoles through Lewis acid-promoted [5 + 2]-annulation of chiral silyl alcohols. Org Lett. 2009 Aug 6; 11(15):3366-9. PMID: 19719185.
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  22. Wrona IE, Lowe JT, Turbyville TJ, Johnson TR, Beignet J, Beutler JA, Panek JS. Synthesis of a 35-member stereoisomer library of bistramide A: evaluation of effects on actin state, cell cycle and tumor cell growth. J Org Chem. 2009 Mar 6; 74(5):1897-916. PMID: 19191575.
    View in: PubMed
  23. Brawn RA, Panek JS. Annulations of enantioenriched allenylsilanes with in situ generated iminium ions: stereoselective synthesis of diverse heterocycles. Org Lett. 2009 Jan 15; 11(2):473-6. PMID: 19072097.
    View in: PubMed
  24. Lowe JT, Panek JS. Total synthesis of (-)-kendomycin. Org Lett. 2008 Sep 4; 10(17):3813-6. PMID: 18698784.
    View in: PubMed
  25. Qin HL, Panek JS. Total synthesis of the Hsp90 inhibitor geldanamycin. Org Lett. 2008 Jun 19; 10(12):2477-9. PMID: 18489177.
    View in: PubMed
  26. Kesavan S, Panek JS, Porco JA. Preparation of alkylidene indane and related scaffolds and their further elaboration to novel chemotypes. Org Lett. 2007 Dec 6; 9(25):5203-6. PMID: 17997565.
    View in: PubMed
  27. Dandapani S, Duduta M, Panek JS, Porco JA. Skeletal diversity through radical cyclization of tetrahydropyridine scaffolds. Org Lett. 2007 Sep 13; 9(19):3849-52. PMID: 17713919.
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  28. Zhang Y, Panek JS. Total synthesis of herboxidiene/GEX 1A. Org Lett. 2007 Aug 2; 9(16):3141-3. PMID: 17629295.
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  29. Brawn RA, Panek JS. Preparation and use of enantioenriched allenylsilanes for the stereoselective synthesis of homopropargylic ethers. Org Lett. 2007 Jul 5; 9(14):2689-92. PMID: 17559219.
    View in: PubMed
  30. Chen Y, Porco JA, Panek JS. Stereochemical and skeletal diversity employing pipecolate ester scaffolds. Org Lett. 2007 Apr 12; 9(8):1529-32. PMID: 17367153.
    View in: PubMed
  31. Lowe JT, Wrona IE, Panek JS. Total synthesis of bistramide A. Org Lett. 2007 Jan 18; 9(2):327-30. PMID: 17217296.
    View in: PubMed
  32. Qin HL, Lowe JT, Panek JS. Mild reductive opening of aryl pyranosides promoted by scandium(III) triflate. J Am Chem Soc. 2007 Jan 10; 129(1):38-9. PMID: 17199277.
    View in: PubMed
  33. Su Q, Dakin LA, Panek JS. [4 + 2]-annulations of chiral organosilanes: Application to the total synthesis of leucascandrolide A. J Org Chem. 2007 Jan 5; 72(1):2-24. PMID: 17194076.
    View in: PubMed
  34. Ong WW, Beeler AB, Kesavan S, Panek JS, Porco JA. Nucleophilic addition to N-phosphinylimines by rare-earth-metal triflate/trifluoroacetic anhydride activation. Angew Chem Int Ed Engl. 2007; 46(39):7470-2. PMID: 17722135.
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  35. Youngsaye W, Lowe JT, Pohlki F, Ralifo P, Panek JS. Total synthesis and stereochemical reassignment of (+)-neopeltolide. Angew Chem Int Ed Engl. 2007; 46(48):9211-4. PMID: 18022886.
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  36. Dandapani S, Lan P, Beeler AB, Beischel S, Abbas A, Roth BL, Porco JA, Panek JS. Convergent synthesis of complex diketopiperazines derived from pipecolic acid scaffolds and parallel screening against GPCR targets. J Org Chem. 2006 Nov 10; 71(23):8934-45. PMID: 17081025.
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  37. Lowe JT, Youngsaye W, Panek JS. A convenient multigram synthesis of highly enantioenriched methyl 3-silylglycidates. J Org Chem. 2006 Apr 28; 71(9):3639-42. PMID: 16626157.
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  38. Wrona IE, Gabarda AE, Evano G, Panek JS. Total synthesis of reblastatin. J Am Chem Soc. 2005 Nov 2; 127(43):15026-7. PMID: 16248632.
    View in: PubMed
  39. Lipomi DJ, Panek JS. Three-component, room temperature crotylation catalyzed by solid-supported Brønsted acid: enantioselective synthesis of homoallylic carbamates. Org Lett. 2005 Oct 13; 7(21):4701-4. PMID: 16209514.
    View in: PubMed
  40. Kesavan S, Su Q, Shao J, Porco JA, Panek JS. Enantioselective synthesis of linear polypropionate arrays using anthracene-tagged organosilanes. Org Lett. 2005 Sep 29; 7(20):4435-8. PMID: 16178552.
    View in: PubMed
  41. Beeler AB, Acquilano DE, Su Q, Yan F, Roth BL, Panek JS, Porco JA. Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters. J Comb Chem. 2005 Sep-Oct; 7(5):673-81. PMID: 16153061.
    View in: PubMed
  42. Lowe JT, Panek JS. Synthesis and [4 + 2]-annulation of enantioenriched (z)-crotylsilanes: preparation of the C1-C13 fragment of bistramide A. Org Lett. 2005 Jul 21; 7(15):3231-4. PMID: 16018628.
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  43. Su S, Acquilano DE, Arumugasamy J, Beeler AB, Eastwood EL, Giguere JR, Lan P, Lei X, Min GK, Yeager AR, Zhou Y, Panek JS, Snyder JK, Schaus SE, Porco JA. Convergent synthesis of a complex oxime library using chemical domain shuffling. Org Lett. 2005 Jun 23; 7(13):2751-4. PMID: 15957938.
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  44. Arefolov A, Panek JS. Crotylsilane reagents in the synthesis of complex polyketide natural products: total synthesis of (+)-discodermolide. J Am Chem Soc. 2005 Apr 20; 127(15):5596-603. PMID: 15826198.
    View in: PubMed
  45. Lowe JT, Panek JS. Stereocontrolled [4+2]-annulation accessing dihydropyrans: synthesis of the C1a-C10 fragment of kendomycin. Org Lett. 2005 Apr 14; 7(8):1529-32. PMID: 15816744.
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  46. Su Q, Panek JS. Total synthesis of (+)-leucascandrolide A. Angew Chem Int Ed Engl. 2005 Feb 11; 44(8):1223-5. PMID: 15654683.
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  47. Huang H, Panek JS. Total synthesis of callipeltoside A. Org Lett. 2004 Nov 11; 6(23):4383-5. PMID: 15524489.
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  48. Lipomi DJ, Langille NF, Panek JS. Total synthesis of basiliskamides A and B. Org Lett. 2004 Sep 30; 6(20):3533-6. PMID: 15387541.
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  49. Shao J, Panek JS. Total synthesis of cystothiazoles A and B. Org Lett. 2004 Sep 2; 6(18):3083-5. PMID: 15330593.
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  50. Langille NF, Panek JS. Total synthesis of (-)-callystatin A. Org Lett. 2004 Sep 2; 6(18):3203-6. PMID: 15330623.
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  51. Su Q, Panek JS. Total synthesis of (-)-apicularen A. J Am Chem Soc. 2004 Mar 3; 126(8):2425-30. PMID: 14982450.
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  52. Evano G, Schaus JV, Panek JS. A convergent synthesis of the macrocyclic core of cytotrienins: application of RCM for macrocyclization. Org Lett. 2004 Feb 19; 6(4):525-8. PMID: 14961614.
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  53. Carter KD, Panek JS. Total synthesis of herbimycin A. Org Lett. 2004 Jan 8; 6(1):55-7. PMID: 14703349.
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  54. Dakin LA, Panek JS. Enantioselective [4 + 2]-annulation of chiral crotylsilanes: application to the synthesis of a C1-C22 fragment of leucascandrolide A. Org Lett. 2003 Oct 16; 5(21):3995-8. PMID: 14535762.
    View in: PubMed
  55. Su Q, Beeler AB, Lobkovsky E, Porco JA, Panek JS. Stereochemical diversity through cyclodimerization: synthesis of polyketide-like macrodiolides. Org Lett. 2003 Jun 12; 5(12):2149-52. PMID: 12790551.
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  56. Huang H, Panek JS. Organosilanes in synthesis: application to an enantioselective synthesis of methyl-l-callipeltose. Org Lett. 2003 May 29; 5(11):1991-3. PMID: 12762704.
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  57. Langille NF, Dakin LA, Panek JS. A mild, chemoselective protocol for the removal of thioketals and thioacetals mediated by Dess-Martin periodinane. Org Lett. 2003 Feb 20; 5(4):575-8. PMID: 12583773.
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  58. Huang H, Spande TF, Panek JS. Highly enantioenriched tetrahydropyridines from chiral organosilanes: application to the synthesis of quinolizidine alkaloid (-)-217A. J Am Chem Soc. 2003 Jan 22; 125(3):626-7. PMID: 12526650.
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  59. Hu T, Takenaka N, Panek JS. Asymmetric crotylation reactions in synthesis of polypropionate-derived macrolides: application to total synthesis of oleandolide. J Am Chem Soc. 2002 Oct 30; 124(43):12806-15. PMID: 12392427.
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  60. Hu T, Panek JS. Enantioselective synthesis of the protein phosphatase inhibitor (-)-motuporin. J Am Chem Soc. 2002 Sep 25; 124(38):11368-78. PMID: 12236752.
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  61. Dakin LA, Langille NF, Panek JS. Synthesis of the C1'-C11' oxazole-containing side chain of leucascandrolide A. Application of a Sonogashira cross-coupling. J Org Chem. 2002 Sep 20; 67(19):6812-5. PMID: 12227815.
    View in: PubMed
  62. Langille NF, Dakin LA, Panek JS. Sonogashira coupling of functionalized trifloyl oxazoles and thiazoles with terminal alkynes: synthesis of disubstituted heterocycles. Org Lett. 2002 Jul 25; 4(15):2485-8. PMID: 12123357.
    View in: PubMed
  63. Arefolov A, Panek JS. Studies directed toward the total synthesis of discodermolide: asymmetric synthesis of the C1-C14 fragment. Org Lett. 2002 Jul 11; 4(14):2397-400. PMID: 12098256.
    View in: PubMed
  64. Liu P, Binnun ED, Schaus JV, Valentino NM, Panek JS. Stereoselective additions of chiral (E)-crotylsilanes to thionium ions: asymmetric synthesis of homoallylic thioethers. J Org Chem. 2002 Mar 8; 67(5):1705-7. PMID: 11871910.
    View in: PubMed
  65. Arefolov A, Langille NF, Panek JS. Stereoselective synthesis of functionalized trisubstituted olefins via palladium(0)-catalyzed cross-coupling reaction. Org Lett. 2001 Oct 18; 3(21):3281-4. PMID: 11594814.
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  66. Sui M, Panek JS. Enhanced diastereoselectivity in asymmetric crotylation reactions using propargylic dicobalt hexacarbonyl complexes. Org Lett. 2001 Aug 9; 3(16):2439-42. PMID: 11483029.
    View in: PubMed
  67. Huang H, Panek JS. Formal [4+2]-annulation of chiral crotylsilanes: synthesis of the C19-C28 fragment of phorboxazoles. Org Lett. 2001 May 31; 3(11):1693-6. PMID: 11405688.
    View in: PubMed
  68. Panek JS, Jain NF. Total synthesis of rutamycin B and oligomycin C. J Org Chem. 2001 Apr 20; 66(8):2747-56. PMID: 11304197.
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  69. Masse CE, Morgan AJ, Panek JS. An asymmetric aminohydroxylation approach to the azepine core of (-)-balanol. Org Lett. 2000 Aug 24; 2(17):2571-3. PMID: 10990399.
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  70. Zhu B, Panek JS. Total synthesis of epothilone A. Org Lett. 2000 Aug 24; 2(17):2575-8. PMID: 10990400.
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  71. Schaus JV, Panek JS. Palladium-catalyzed cross-coupling of terminal alkynes with 4-trifloyloxazole: studies toward the construction of the C26-C31 subunit of phorboxazole A. Org Lett. 2000 Feb 24; 2(4):469-71. PMID: 10814353.
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  72. Morgan AJ, Masse CE, Panek JS. Reversal of regioselection in the sharpless asymmetric aminohydroxylation of aryl ester substrates. Org Lett. 1999 Dec 16; 1(12):1949-52. PMID: 10836053.
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  73. Hu T, Panek JS. Total Synthesis of (-)-Motuporin. J Org Chem. 1999 Apr 30; 64(9):3000-3001. PMID: 11674393.
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  74. Panek JS, Masse CE. Total synthesis of (+)-lactacystin. Angew Chem Int Ed Engl. 1999; 38(8):1093-5. PMID: 25138505.
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  75. Panek JS, Masse CE. Total Synthesis of (+)-Mycotrienol and (+)-Mycotrienin I. J Org Chem. 1997 Nov 28; 62(24):8290-8291. PMID: 11671962.
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  76. Panek JS, Beresis RT. Studies Directed toward the Synthesis of Ulapualide A. Asymmetric Synthesis of the C8-C25 Tris-Oxazole Fragment. J Org Chem. 1996 Sep 20; 61(19):6496-6497. PMID: 11667510.
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  77. Panek JS, Beresis RT, Celatka CA. Studies Directed toward the Synthesis of Ulapualide A. Asymmetric Synthesis of the C26-C42 Fragment. J Org Chem. 1996 Sep 20; 61(19):6494-6495. PMID: 11667509.
    View in: PubMed
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