James Panek, PhD
Samour Family Professor in Organic Chemistry
Boston University College of Arts and Sciences
Dept of Chemistry

PhD, University of Kansas
MS, University of Kansas



Research activities in the Panek Group emphasize the area of synthetic organic chemistry, in particular the induction of chirality. The problems under study reflect their general interest in the synthesis of new reagents and development of new reaction methods. Ongoing studies in the area of natural product synthesis generate a complementary research effort. In the synthesis of complex organic molecules, new research methods are employed or developed to carry out the defined objectives. They are also affiliated with the Center for Molecular Discovery.


Academic Program Support for Abbvie Chemistry symposium
02/25/2015 - 05/31/2015 (PI)
AbbVie

COMPLEX CHEMOTYPES: DISCOVERY, METHODOLOGY, AND LIBRARY EXPANSION - LSC
09/01/2010 - 08/31/2014 (SP Co-PI of Sub-Project / SP)
PI: John A. Porco, PhD
NIH/National Institute of General Medica
5P50GM067041-10




Yr Title Project-Sub Proj Pubs
2007 Synthesis of Polyprionate Derived Natural Products 5R01GM055740-07 23
2006 Synthesis of Polyprionate Derived Natural Products 5R01GM055740-06 23
2006 Asymmetric Synthesis of Antitumor Agents 5R01CA056304-13 23
2005 Synthesis of Polyprionate Derived Natural Products 5R01GM055740-05 23
2005 Asymmetric Synthesis of Antitumor Agents 5R01CA056304-12 23
2004 Synthesis of Polyprionate Derived Natural Products 2R01GM055740-04A2 23
2004 Asymmetric Synthesis of Antitumor Agents 5R01CA056304-11 23
2003 Asymmetric Synthesis of Antitumor Agents 5R01CA056304-10 23
2002 Asymmetric Synthesis of Antitumor Agents 2R01CA056304-09 23
2001 ASYMMETRIC SYNTHESIS OF ANTITUMOR AGENTS 5R01CA056304-08 23
Showing 10 of 25 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Alshammari A, Patel J, Al-Hashemi J, Cai B, Panek J, Huck O, Amar S. Kava-241 Reduced Periodontal Destruction in a Collagen Antibody Primed Porphyromonas gingivalis Model of Periodontitis. J Clin Periodontol. 2017 Jul 26. PMID: 28746780.
  2. Allen EE, Zhu C, Panek JS, Schaus SE. Multicomponent Condensation Reactions via ortho-Quinone Methides. Org Lett. 2017 Apr 07; 19(7):1878-1881.View Related Profiles. PMID: 28357870; DOI: 10.1021/acs.orglett.7b00647;.
  3. Cai B, Evans RW, Wu J, Panek JS. Total Synthesis of Nuclear Factor of Activated T-Cells-68 (NFAT-68): Sequential Use of Chiral Allenylsilane and Titanium Alkoxide-Mediated Reductive Coupling Bond Construction. Org Lett. 2016 Sep 02; 18(17):4304-7. PMID: 27513364; DOI: 10.1021/acs.orglett.6b02052;.
  4. Cai B, Panek JS, Amar S. Convergent Synthesis of Novel Muramyl Dipeptide Analogues: Inhibition of Porphyromonas gingivalis-Induced Pro-inflammatory Effects by High Doses of Muramyl Dipeptide. J Med Chem. 2016 Jul 28; 59(14):6878-90.View Related Profiles. PMID: 27353235; DOI: 10.1021/acs.jmedchem.6b00681;.
  5. Barbato KS, Luan Y, Ramella D, Panek JS, Schaus SE. Enantioselective Multicomponent Condensation Reactions of Phenols, Aldehydes, and Boronates Catalyzed by Chiral Biphenols. Org Lett. 2015 Dec 4; 17(23):5812-5.View Related Profiles. PMID: 26576776; PMCID: PMC4671505; DOI: 10.1021/acs.orglett.5b02954;.
  6. Lee J, Panek JS. Total synthesis of (+)-isatisine a: application of a silicon-directed mukaiyama-type [3 + 2]-annulation. J Org Chem. 2015 Mar 20; 80(6):2959-71. PMID: 25739011; DOI: 10.1021/acs.joc.5b00051;.
  7. Lee J, Panek JS. Synthesis of isochromene-type scaffolds via single-flask Diels-Alder-[4 + 2]-annulation sequence of a silyl-substituted diene with menadione. Org Lett. 2014 Jun 20; 16(12):3320-3. PMID: 24918110; PMCID: PMC4076005; DOI: 10.1021/ol501329t;.
  8. Brawn RA, Zhu K, Panek JS. Rhodium(II)-catalyzed alkyne amination of homopropargylic sulfamate esters: stereoselective synthesis of functionalized norcaradienes by arene cyclopropanation. Org Lett. 2014 Jan 3; 16(1):74-7. PMID: 24328560; DOI: 10.1021/ol403035g;.
  9. Wu J, Pu Y, Panek JS. Divergent synthesis of functionalized carbocycles through organosilane-directed asymmetric alkyne-alkene reductive coupling and annulation sequence. J Am Chem Soc. 2012 Nov 7; 134(44):18440-6. PMID: 23057751; DOI: 10.1021/ja3083945;.
  10. Wu J, Zhu KC, Yuan PW, Panek JS. Bifunctional homoallylic carbamates from chiral silane additions to in situ generated N-acyl iminium ions. Org Lett. 2012 Jul 20; 14(14):3624-7. PMID: 22738355; DOI: 10.1021/ol301428y;.
Showing 10 of 78 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 78 publications over 21 distinct years, with a maximum of 10 publications in 2007

YearPublications
19962
19971
19993
20003
20014
20026
20035
20047
20059
20062
200710
20082
20095
20106
20113
20122
20131
20141
20152
20162
20172
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