John Caradonna, PhD
Associate Professor
Boston University College of Arts and Sciences
Chemistry

PhD, Columbia University
MPhil, Columbia University
MA, Columbia University
MA, Johns Hopkins University
BA, Johns Hopkins University



The Caradonna research group is interested in understanding the mechanism of action of non-heme iron metalloproteins, with a focus on the chemistry of metalloenzyme active sites involved in biological oxidation reactions. Our efforts span the continuum from the investigation of small molecule synthetic complexes that catalyze oxygen atom transfer reactions, to the characterization of an interesting class of iron/pterin-dependent aromatic amino acid hydroxylases (phenylalanine, tyrosine, and tryptophan hydroxylases), to the computational design of functional metalloproteins (iron-sulfur-based electron transfer clusters, Fe and Mn superoxide dismutanse). A broad-based approach, including chemical, molecular biological, and biophysical (spectroscopic) techniques, is used to develop a global understanding of the intrinsic characteristics of the active site metal centers and the role played by the protein matrix in regulating, modulating, and tuning these properties.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




SusCheM: Utilizing Iron-Coenzyme Oxygen Activation in Catalysis
07/01/2013 - 05/31/2017 (PI)
National Science Foundation
CHE-1300122



Title


Yr Title Project-Sub Proj Pubs
2003 BIOLOGICAL OXIDATION OF PHENYLALANINE BY NONHEME IRON 5R01GM061208-04 3
2002 BIOLOGICAL OXIDATION OF PHENYLALANINE BY NONHEME IRON 5R01GM061208-03 3
2001 BIOLOGICAL OXIDATION OF PHENYLALANINE BY NONHEME IRON 5R01GM061208-02 3
2000 BIOLOGICAL OXIDATION OF PHENYLALANINE BY NONHEME IRON 1R01GM061208-01 3
1995 STRUCTURAL CHARACTERIZATION OF SP1-DNA COMPLEXES 5R01GM048396-04
1994 STRUCTURAL CHARACTERIZATION OF SP1-DNA COMPLEXES 5R01GM048396-03
1993 STRUCTURAL CHARACTERIZATION OF SP1-DNA COMPLEXES 5R01GM048396-02
1992 STRUCTURAL CHARACTERIZATION OF SP1-DNA COMPLEXES 1R01GM048396-01
1989 UPGRADE &PURCHASE OF A HIGH FIELD NMR SPECTROMETER 1S10RR004765-01
1986 MODELING THE MO COFACTOR OF SULFITE OXIDASE 5F32GM010096-02

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. McCracken J, Cappillino PJ, McNally JS, Krzyaniak MD, Howart M, Tarves PC, Caradonna JP. Characterization of Water Coordination to Ferrous Nitrosyl Complexes with fac-N2O, cis-N2O2, and N2O3 Donor Ligands. Inorg Chem. 2015 Jul 6; 54(13):6486-97. PMID: 26090963; DOI: 10.1021/acs.inorgchem.5b00788;
     
  2. Cappillino PJ, Miecznikowski JR, Tyler LA, Tarves PC, McNally JS, Lo W, Kasibhatla BS, Krzyaniak MD, McCracken J, Wang F, Armstrong WH, Caradonna JP. Studies of iron(II) and iron(III) complexes with fac-N2O, cis-N2O2 and N2O3 donor ligands: models for the 2-His 1-carboxylate motif of non-heme iron monooxygenases. Dalton Trans. 2012 May 14; 41(18):5662-77. PMID: 22434362; DOI: 10.1039/c2dt11096b;
     
  3. Gregor LC, Rowe GT, Rybak-Akimova E, Caradonna JP. Mechanistic investigation of cyclohexane oxidation by a non-heme iron complex: evidence of product inhibition by UV/vis stopped-flow studies. Dalton Trans. 2012 Jan 21; 41(3):777-82. PMID: 22109726; DOI: 10.1039/c1dt11841b;
     
  4. Cappillino PJ, McNally JS, Wang F, Caradonna JP. The effect of varying carboxylate ligation on the electronic environment of N2O(x) (x = 1-3) nonheme iron: a DFT analysis. Dalton Trans. 2012 Jan 14; 41(2):474-83. PMID: 22042235; DOI: 10.1039/c1dt11199j;
     
  5. Cong H, Ledbetter D, Rowe GT, Caradonna JP, Porco JA. Electron transfer-initiated Diels-Alder cycloadditions of 2'-hydroxychalcones. J Am Chem Soc. 2008 Jul 23; 130(29):9214-5.View Related Profiles. PMID: 18576647; PMCID: PMC2635952; DOI: 10.1021/ja803094u;
     
  6. Rowe GT, Rybak-Akimova EV, Caradonna JP. Heterolytic cleavage of peroxide by a diferrous compound generates metal-based intermediates identical to those observed with reactions utilizing oxygen-atom-donor molecules. Chemistry. 2008; 14(27):8303-11. PMID: 18680115; DOI: 10.1002/chem.200800283;
     
  7. Rowe GT, Rybak-Akimova EV, Caradonna JP. Unraveling the reactive species of a functional non-heme iron monooxygenase model using stopped-flow UV-vis spectroscopy. Inorg Chem. 2007 Dec 10; 46(25):10594-606. PMID: 17988120
     
  8. Kemsley JN, Wasinger EC, Datta S, Mitic N, Acharya T, Hedman B, Caradonna JP, Hodgson KO, Solomon EI. Spectroscopic and kinetic studies of PKU-inducing mutants of phenylalanine hydroxylase: Arg158Gln and Glu280Lys. J Am Chem Soc. 2003 May 14; 125(19):5677-86. PMID: 12733906
     
  9. Foster TL, Caradonna JP. Fe2+-catalyzed heterolytic RO-OH bond cleavage and substrate oxidation: a functional synthetic non-heme iron monooxygenase system. J Am Chem Soc. 2003 Apr 2; 125(13):3678-9. PMID: 12656580
     
  10. Wasinger EC, Mitic N, Hedman B, Caradonna J, Solomon EI, Hodgson KO. X-ray absorption spectroscopic investigation of the resting ferrous and cosubstrate-bound active sites of phenylalanine hydroxylase. Biochemistry. 2002 May 21; 41(20):6211-7. PMID: 12009881
     
Showing 10 of 20 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 20 publications over 15 distinct years, with a maximum of 3 publications in 1997

YearPublications
19821
19861
19911
19921
19941
19951
19961
19973
20021
20032
20071
20082
20112
20121
20151

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