Mikel Garcia-Marcos | Profiles RNS

Mikel Garcia-Marcos, PhD

Associate Professor

Boston University School of Medicine

Dept of Biochemistry

PhD, University of the Basque Country

Websites

Biochemistry Faculty

ORCID : 0000-0001-9513-4826

We investigate signal transduction mechanisms with the ultimate goal of elucidating the molecular basis of human diseases and developing novel therapeutic approaches.

Our main interest is in heterotrimeric G proteins, which are molecular switches that relay extracellular signals. Heterotrimeric G proteins are primarily activated by G protein-coupled receptors (GPCRs) located at the plasma membrane. However, our lab focuses on a group of cytoplasmic factors that mimic the action of GPCRs by directly activating heterotrimeric G proteins. These non-receptor activators “rewire” signal transduction in different pathological settings, including cancer, fibrosis, insulin resistance and kidney failure, among many others.

Our current efforts are focused on:
(i) identifying the members of this group of non-receptor activators
(ii) defining their role in normal and pathological scenarios
(iii) characterizing the molecular mechanisms by which they are regulated
(iv) understanding the structural basis for their action on G proteins
(v) developing tools to specifically target them.

We are currently exploring this unconventional aspect of G protein signaling in the context of cancer, embryonic development and neurotransmission.Our multidisciplinary approach includes in vitro biochemistry to characterize protein complexes, cultured cells and model organisms (yeast, frog embryos, fish) for functional studies, and synthetic biology tools to manipulate and monitor signaling with exquisite spatiotemporal resolution..

BU Sponsored Research
NIH RePORTER Sponsored Research

Targeting of Non-Canonical G Protein Signaling with Small Molecules
07/01/2018 - 06/30/2022 (PI)
NIH/National Institute of General Medical Sciences
1R01GM130120-01

Alternative Mechanisms of Signaling via Trimeric G Proteins
09/01/2014 - 08/31/2019 (PI)
NIH/National Institute of General Medical Sciences
5R01GM108733-04

Identification of chemical probes that specifically disrupt the GIV-Gi interface
01/01/2015 - 12/31/2018 (PI)
NIH/National Institute of General Medical Sciences
5R01GM112631-03

Student Intern Agreement with Universidad Francisco de Vitoria - Covadonga Lopez Ramos
02/01/2018 - 07/31/2018 (PI)
Universidad Francisco de Vitoria

Student Intern Agreement with Unviersidad Francisco de Vitoria-Alberto Garcia Lopez
02/01/2018 - 07/31/2018 (PI)
Universidad Francisco de Vitoria

Molecular Mechanisms and Validation of a Novel Target in Cancer
07/01/2013 - 06/30/2018 (PI)
American Cancer Society, Inc.

Student Intern Agreement with Universidad Francisco de Vitoria
02/21/2014 - 06/21/2015 (PI)
Universidad Francisco de Vitoria

Targeting a novel G protein activator for cancer therapeutics
01/01/2013 - 12/31/2013 (PI)
Elsa U. Pardee Foundation

Yr	Title	Project-Sub Proj	Pubs
2018	Targeting of non-canonical G protein signaling with small molecules	1R01GM130120-01
2017	Identification of chemical probes that specifically disrupt the GIV-Gi interface	5R01GM112631-03	3
2017	Alternative mechanisms of signaling via trimeric G proteins	5R01GM108733-04	5
2016	Identification of chemical probes that specifically disrupt the GIV-Gi interface	5R01GM112631-02	3
2016	Alternative mechanisms of signaling via trimeric G proteins	5R01GM108733-03	5
2015	Identification of chemical probes that specifically disrupt the GIV-Gi interface	1R01GM112631-01	3
2015	Alternative mechanisms of signaling via trimeric G proteins	5R01GM108733-02	5
2014	Alternative mechanisms of signaling via trimeric G proteins	1R01GM108733-01A1	5

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Martemyanov KA, Garcia-Marcos M. Making useful gadgets with miniaturized G proteins. J Biol Chem. 2018 May 11; 293(19):7474-7475. PMID: 29752421.

Leyme A, Marivin A, Maziarz M, DiGiacomo V, Papakonstantinou MP, Patel PP, Blanco-Canosa JB, Walawalkar IA, Rodriguez-Davila G, Dominguez I, Garcia-Marcos M. Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein. Proc Natl Acad Sci U S A. 2017 11 28; 114(48):E10319-E10328.View Related Profiles.

Leyme, Anthony
Garcia-Marcos, Mikel

PMID: 29133411.

DiGiacomo V, Marivin A, Garcia-Marcos M. When Heterotrimeric G Proteins Are Not Activated by G Protein-Coupled Receptors: Structural Insights and Evolutionary Conservation. Biochemistry. 2018 01 23; 57(3):255-257. PMID: 29035513.

Maziarz M, Garcia-Marcos M. Rapid kinetic BRET measurements to monitor G protein activation by GPCR and non-GPCR proteins. Methods Cell Biol. 2017; 142:145-157. PMID: 28964333.

Maziarz M, Garcia-Marcos M. Fluorescence polarization assays to measure interactions between Ga subunits of heterotrimeric G proteins and regulatory motifs. Methods Cell Biol. 2017; 142:133-143. PMID: 28964332.

DiGiacomo V, de Opakua AI, Papakonstantinou MP, Nguyen LT, Merino N, Blanco-Canosa JB, Blanco FJ, Garcia-Marcos M. The Gai-GIV binding interface is a druggable protein-protein interaction. Sci Rep. 2017 Aug 17; 7(1):8575. PMID: 28819150.

de Opakua AI, Parag-Sharma K, DiGiacomo V, Merino N, Leyme A, Marivin A, Villate M, Nguyen LT, de la Cruz-Morcillo MA, Blanco-Canosa JB, Ramachandran S, Baillie GS, Cerione RA, Blanco FJ, Garcia-Marcos M. Molecular mechanism of Gai activation by non-GPCR proteins with a Ga-Binding and Activating motif. Nat Commun. 2017 May 18; 8:15163.View Related Profiles.

Leyme, Anthony
Garcia-Marcos, Mikel

PMID: 28516903.

Parag-Sharma K, Leyme A, DiGiacomo V, Marivin A, Broselid S, Garcia-Marcos M. Membrane Recruitment of the Non-receptor Protein GIV/Girdin (Ga-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling. J Biol Chem. 2016 Dec 30; 291(53):27098-27111.View Related Profiles.

Leyme, Anthony
Garcia-Marcos, Mikel

PMID: 27864364; DOI: 10.1074/jbc.M116.764431;.

Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P. GIV/Girdin activates Gai and inhibits Gas via the same motif. Proc Natl Acad Sci U S A. 2016 09 27; 113(39):E5721-30.View Related Profiles.

Leyme, Anthony
Garcia-Marcos, Mikel

PMID: 27621449; DOI: 10.1073/pnas.1609502113;.

Garcia-Marcos M, VanHook AM. Science Signaling Podcast for 12 April 2016: G proteins in auriculo-condylar syndrome. Sci Signal. 2016; 9(423):pc9. PMID: 27072654; DOI: 10.1126/scisignal.aaf7740;.

Showing 10 of 46 results. Show More

Marivin A, Leyme A, Parag-Sharma K, DiGiacomo V, Cheung AY, Nguyen LT, Dominguez I, Garcia-Marcos M. Dominant-negative Ga subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease. Sci Signal. 2016 Apr 12; 9(423):ra37.View Related Profiles.

Leyme, Anthony
Dominguez, Maria Isabel
Garcia-Marcos, Mikel

PMID: 27072656; PMCID: PMC4870087; DOI: 10.1126/scisignal.aad2429;.

Leyme A, Marivin A, Garcia-Marcos M. GIV/Girdin (Ga-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells. J Biol Chem. 2016 Apr 8; 291(15):8269-82.View Related Profiles.

Leyme, Anthony
Garcia-Marcos, Mikel

PMID: 26887938; PMCID: PMC4825026; DOI: 10.1074/jbc.M115.691550;.

Coleman BD, Marivin A, Parag-Sharma K, DiGiacomo V, Kim S, Pepper JS, Casler J, Nguyen LT, Koelle MR, Garcia-Marcos M. Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein Activation. Mol Biol Evol. 2016 Mar; 33(3):820-37. PMID: 26659249; PMCID: PMC4760084; DOI: 10.1093/molbev/msv336;.

Leyme A, Marivin A, Perez-Gutierrez L, Nguyen LT, Garcia-Marcos M. Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin. J Cell Biol. 2015 Sep 28; 210(7):1165-84.View Related Profiles.

Leyme, Anthony
Garcia-Marcos, Mikel

PMID: 26391662; PMCID: PMC4586755; DOI: 10.1083/jcb.201506041;.

Bhandari D, Lopez-Sanchez I, To A, Lo IC, Aznar N, Leyme A, Gupta V, Niesman I, Maddox AL, Garcia-Marcos M, Farquhar MG, Ghosh P. Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy. Proc Natl Acad Sci U S A. 2015 Sep 1; 112(35):E4874-83.View Related Profiles.

Leyme, Anthony
Garcia-Marcos, Mikel

PMID: 26286990; PMCID: PMC4568279; DOI: 10.1073/pnas.1514157112;.

Aznar N, Midde KK, Dunkel Y, Lopez-Sanchez I, Pavlova Y, Marivin A, Barbazán J, Murray F, Nitsche U, Janssen KP, Willert K, Goel A, Abal M, Garcia-Marcos M, Ghosh P. Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling. Elife. 2015; 4:e07091. PMID: 26126266; PMCID: PMC4484057; DOI: 10.7554/eLife.07091;.

Garcia-Marcos M, Ghosh P, Farquhar MG. GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation. J Biol Chem. 2015 Mar 13; 290(11):6697-704. PMID: 25605737; PMCID: PMC4358093; DOI: 10.1074/jbc.R114.613414;.

Lin C, Ear J, Midde K, Lopez-Sanchez I, Aznar N, Garcia-Marcos M, Kufareva I, Abagyan R, Ghosh P. Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. Mol Biol Cell. 2014 Nov 5; 25(22):3654-71. PMID: 25187647; PMCID: PMC4230624; DOI: 10.1091/mbc.E14-05-0978;.

Colvin TA, Gabai VL, Gong J, Calderwood SK, Li H, Gummuluru S, Matchuk ON, Smirnova SG, Orlova NV, Zamulaeva IA, Garcia-Marcos M, Li X, Young ZT, Rauch JN, Gestwicki JE, Takayama S, Sherman MY. Hsp70-Bag3 interactions regulate cancer-related signaling networks. Cancer Res. 2014 Sep 1; 74(17):4731-40.View Related Profiles.

Gong, Jianlin
Sherman, Michael
Garcia-Marcos, Mikel
Gummuluru, Suryaram
Colvin, Teresa
Gabai, Vladimir

PMID: 24994713; PMCID: PMC4174322; DOI: 10.1158/0008-5472.CAN-14-0747;.

Leyme A, Marivin A, Casler J, Nguyen LT, Garcia-Marcos M. Different biochemical properties explain why two equivalent Ga subunit mutants cause unrelated diseases. J Biol Chem. 2014 Aug 8; 289(32):21818-27.View Related Profiles.

Leyme, Anthony
Garcia-Marcos, Mikel

PMID: 24982418; PMCID: PMC4139202; DOI: 10.1074/jbc.M114.549790;.

López-Sánchez I, Garcia-Marcos M, Mittal Y, Aznar N, Farquhar MG, Ghosh P. Protein kinase C-theta (PKC?) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin. Proc Natl Acad Sci U S A. 2013 Apr 2; 110(14):5510-5. PMID: 23509302; PMCID: PMC3619294; DOI: 10.1073/pnas.1303392110;.

Beas AO, Taupin V, Teodorof C, Nguyen LT, Garcia-Marcos M, Farquhar MG. Gas promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin). Mol Biol Cell. 2012 Dec; 23(23):4623-34. PMID: 23051738; PMCID: PMC3510023; DOI: 10.1091/mbc.E12-02-0133;.

Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. GuidView Related Profiles.

Garcia-Marcos, Mikel
Ruiz-Opazo, Nelson
Shirihai, Orian
Wang, Zhi

PMID: 22966490; PMCID: PMC3404883.

Garcia-Marcos M, Kietrsunthorn PS, Pavlova Y, Adia MA, Ghosh P, Farquhar MG. Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling. Proc Natl Acad Sci U S A. 2012 Feb 7; 109(6):1961-6. PMID: 22308453; PMCID: PMC3277514; DOI: 10.1073/pnas.1120538109;.

Lin C, Ear J, Pavlova Y, Mittal Y, Kufareva I, Ghassemian M, Abagyan R, Garcia-Marcos M, Ghosh P. Tyrosine phosphorylation of the Ga-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration. Sci Signal. 2011 Sep 27; 4(192):ra64. PMID: 21954290; DOI: 10.1126/scisignal.2002049;.

Mittal Y, Pavlova Y, Garcia-Marcos M, Ghosh P. Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway. J Biol Chem. 2011 Sep 16; 286(37):32404-15. PMID: 21799016; PMCID: PMC3173146; DOI: 10.1074/jbc.M111.275685;.

Garcia-Marcos M, Kietrsunthorn PS, Wang H, Ghosh P, Farquhar MG. G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs. J Biol Chem. 2011 Aug 12; 286(32):28138-49. PMID: 21653697; PMCID: PMC3151059; DOI: 10.1074/jbc.M110.204099;.

Ghosh P, Garcia-Marcos M, Farquhar MG. GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression. Cell Adh Migr. 2011 May-Jun; 5(3):237-48. PMID: 21546796; PMCID: PMC3210208.

Garcia-Marcos M, Ghosh P, Farquhar MG. Molecular basis of a novel oncogenic mutation in GNAO1. Oncogene. 2011 Jun 9; 30(23):2691-6. PMID: 21317923; PMCID: PMC3349449; DOI: 10.1038/onc.2010.645;.

Garcia-Marcos M, Ear J, Farquhar MG, Ghosh P. A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals. Mol Biol Cell. 2011 Mar 1; 22(5):673-86. PMID: 21209316; PMCID: PMC3046063; DOI: 10.1091/mbc.E10-08-0738;.

Garcia-Marcos M, Jung BH, Ear J, Cabrera B, Carethers JM, Ghosh P. Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer. FASEB J. 2011 Feb; 25(2):590-9. PMID: 20974669; PMCID: PMC3023389; DOI: 10.1096/fj.10-167304;.

Fontanils U, Seil M, Pochet S, El Ouaaliti M, Garcia-Marcos M, Dehaye JP, Marino A. Stimulation by P2X7 receptors of calcium-dependent production of reactive oxygen species (ROS) in rat submandibular glands. Biochim Biophys Acta. 2010 Nov; 1800(11):1183-91. PMID: 20655985; DOI: 10.1016/j.bbagen.2010.07.007;.

Ghosh P, Beas AO, Bornheimer SJ, Garcia-Marcos M, Forry EP, Johannson C, Ear J, Jung BH, Cabrera B, Carethers JM, Farquhar MG. A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell. 2010 Jul 1; 21(13):2338-54. PMID: 20462955; PMCID: PMC2893996; DOI: 10.1091/mbc.E10-01-0028;.

Garcia-Marcos M, Ghosh P, Ear J, Farquhar MG. A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem. 2010 Apr 23; 285(17):12765-77. PMID: 20157114; PMCID: PMC2857069; DOI: 10.1074/jbc.M109.045161;.

Garcia-Marcos M, Ghosh P, Farquhar MG. GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. Proc Natl Acad Sci U S A. 2009 Mar 3; 106(9):3178-83. PMID: 19211784; PMCID: PMC2651282; DOI: 10.1073/pnas.0900294106;.

Garcia-Marcos M, Dehaye JP, Marino A. Membrane compartments and purinergic signalling: the role of plasma membrane microdomains in the modulation of P2XR-mediated signalling. FEBS J. 2009 Jan; 276(2):330-40. PMID: 19076211; DOI: 10.1111/j.1742-4658.2008.06794.x;.

Ghosh P, Garcia-Marcos M, Bornheimer SJ, Farquhar MG. Activation of Galphai3 triggers cell migration via regulation of GIV. J Cell Biol. 2008 Jul 28; 182(2):381-93. PMID: 18663145; PMCID: PMC2483528; DOI: 10.1083/jcb.200712066;.

Seil M, Fontanils U, Etxebarria IG, Pochet S, Garcia-Marcos M, Marino A, Dehaye JP. Pharmacological evidence for the stimulation of NADPH oxidase by P2X(7) receptors in mouse submandibular glands. Purinergic Signal. 2008 Dec; 4(4):347-55. PMID: 18581262; PMCID: PMC2583204; DOI: 10.1007/s11302-008-9118-y;.

Pochet S, Garcia-Marcos M, Seil M, Otto A, Marino A, Dehaye JP. Contribution of two ionotropic purinergic receptors to ATP responses in submandibular gland ductal cells. Cell Signal. 2007 Oct; 19(10):2155-64. PMID: 17651941.

Garcia-Marcos M, Pochet S, Marino A, Dehaye JP. P2X7 and phospholipid signalling: the search of the "missing link" in epithelial cells. Cell Signal. 2006 Dec; 18(12):2098-104. PMID: 16815675.

García-Marcos M, Pochet S, Tandel S, Fontanils U, Astigarraga E, Fernández-González JA, Kumps A, Marino A, Dehaye JP. Characterization and comparison of raft-like membranes isolated by two different methods from rat submandibular gland cells. Biochim Biophys Acta. 2006 Jun; 1758(6):796-806. PMID: 16842738; DOI: 10.1016/j.bbamem.2006.05.008;.

Pochet S, Tandel S, Querriére S, Tre-Hardy M, Garcia-Marcos M, De Lorenzi M, Vandenbranden M, Marino A, Devleeschouwer M, Dehaye JP. Modulation by LL-37 of the responses of salivary glands to purinergic agonists. Mol Pharmacol. 2006 Jun; 69(6):2037-46. PMID: 16514052.

Garcia-Marcos M, Pérez-Andrés E, Tandel S, Fontanils U, Kumps A, Kabré E, Gómez-Muñoz A, Marino A, Dehaye JP, Pochet S. Coupling of two pools of P2X7 receptors to distinct intracellular signaling pathways in rat submandibular gland. J Lipid Res. 2006 Apr; 47(4):705-14. PMID: 16415476.

Garcia-Marcos M, Fontanils U, Aguirre A, Pochet S, Dehaye JP, Marino A. Role of sodium in mitochondrial membrane depolarization induced by P2X7 receptor activation in submandibular glands. FEBS Lett. 2005 Oct 10; 579(24):5407-13. PMID: 16198349; DOI: 10.1016/j.febslet.2005.08.074;.

Garcia-Marcos M, Tandel S, Pochet S, Genin J, De Lorenzi M, Gomez F, Kumps A, Marino A, Dehaye JP. Cholesterol depletion perturbs calcium handling by rat submandibular glands. J Cell Physiol. 2005 May; 203(2):429-38. PMID: 15521067; DOI: 10.1002/jcp.20241;.

Pochet S, García-Marcos M, Fernandez M, Marino A, Dehaye JP. Regulation by clozapine of calcium handling by rat submandibular acinar cells. Cell Calcium. 2003 Dec; 34(6):465-75. PMID: 14572805.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 46 publications over 15 distinct years, with a maximum of 6 publications in 2011 and 2017

Bar chart showing 46 publications over 15 distinct years, with a maximum of 6 publications in 2011 and 2017

Year	Publications
2003	1
2005	2
2006	4
2007	1
2008	3
2009	1
2010	4
2011	6
2012	3
2013	1
2014	3
2015	5
2016	5
2017	6
2018	1

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