Mikel Garcia-Marcos, PhD
Associate Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of the Basque Country




We investigate signal transduction mechanisms with the ultimate goal of elucidating the molecular basis of human diseases and developing novel therapeutic approaches.

Our main interest is in heterotrimeric G proteins, which are molecular switches that relay extracellular signals. Heterotrimeric G proteins are primarily activated by G protein-coupled receptors (GPCRs) located at the plasma membrane. However, our lab focuses on a group of cytoplasmic factors that mimic the action of GPCRs by directly activating heterotrimeric G proteins. These non-receptor activators “rewire” signal transduction in different pathological settings, including cancer, fibrosis, insulin resistance and kidney failure, among many others.

Our current efforts are focused on:
(i) identifying the members of this group of non-receptor activators
(ii) defining their role in normal and pathological scenarios
(iii) characterizing the molecular mechanisms by which they are regulated
(iv) understanding the structural basis for their action on G proteins
(v) developing tools to specifically target them.

We are currently exploring this unconventional aspect of G protein signaling in the context of cancer, embryonic development and neurotransmission.Our multidisciplinary approach includes in vitro biochemistry to characterize protein complexes, cultured cells and model organisms (yeast, frog embryos, fish) for functional studies, and synthetic biology tools to manipulate and monitor signaling with exquisite spatiotemporal resolution..

Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute




Non-canonical activation of heterotrimeric G protein signaling in vivo
09/20/2019 - 07/31/2023 (PI)
NIH/National Institute of General Medical Sciences
1R01GM136132-01

Targeting of non-canonical G protein signaling with small molecules
07/01/2018 - 06/30/2022 (PI)
NIH/National Institute of General Medical Sciences
5R01GM130120-02

Next generation G protein activity biosensors
09/22/2018 - 08/31/2020 (PI)
NIH/National Institute of Mental Health
5R21MH118745-02

Alternative Mechanisms of Signaling via Trimeric G Proteins
09/01/2014 - 08/31/2020 (PI)
NIH/National Institute of General Medical Sciences
3R01GM108733-05S1

Student Intern Agreement with Universidad Francisco de Vitoria 2019
03/01/2019 - 07/15/2019 (PI)
Universidad Francisco de Vitoria


Identification of chemical probes that specifically disrupt the GIV-Gi interface
01/01/2015 - 12/31/2018 (PI)
NIH/National Institute of General Medical Sciences
5R01GM112631-03

Student Intern Agreement with Universidad Francisco de Vitoria - Covadonga Lopez Ramos
02/01/2018 - 07/31/2018 (PI)
Universidad Francisco de Vitoria


Student Intern Agreement with Unviersidad Francisco de Vitoria-Alberto Garcia Lopez
02/01/2018 - 07/31/2018 (PI)
Universidad Francisco de Vitoria


Molecular Mechanisms and Validation of a Novel Target in Cancer
07/01/2013 - 06/30/2018 (PI)
American Cancer Society, Inc.


Student Intern Agreement with Universidad Francisco de Vitoria
02/21/2014 - 06/21/2015 (PI)
Universidad Francisco de Vitoria


Showing 10 of 11 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2020 Alternative mechanisms of signaling via trimeric G proteins 9R01NS117101-06A1
2019 Non-canonical activation of heterotrimeric G protein signaling in vivo 1R01GM136132-01
2019 Next generation G protein activity biosensors 5R21MH118745-02 1
2019 Targeting of non-canonical G protein signaling with small molecules 5R01GM130120-02 3
2018 Next generation G protein activity biosensors 1R21MH118745-01 1
2018 Targeting of non-canonical G protein signaling with small molecules 1R01GM130120-01 3
2018 Alternative mechanisms of signaling via trimeric G proteins 5R01GM108733-05 21
2018 Alternative mechanisms of signaling via trimeric G proteins 3R01GM108733-05S1 21
2017 Identification of chemical probes that specifically disrupt the GIV-Gi interface 5R01GM112631-03 13
2017 Alternative mechanisms of signaling via trimeric G proteins 5R01GM108733-04 21
Showing 10 of 15 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Maziarz M, Park JC, Leyme A, Marivin A, Garcia-Lopez A, Patel PP, Garcia-Marcos M. Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design. Cell. 2020 Jun 27.View Related Profiles. PMID: 32634377
     
  2. Marivin A, Maziarz M, Zhao J, DiGiacomo V, Calvo IO, Mann EA, Ear J, Blanco-Canosa JB, Ross EM, Ghosh P, Garcia-Marcos M. Correction: DAPLE protein inhibits nucleotide exchange on Gas and Gaq via the same motif that activates Gai. J Biol Chem. 2020 Jun 26; 295(26):8867.View Related Profiles. PMID: 32591443
     
  3. DiGiacomo V, Maziarz M, Luebbers A, Norris JM, Laksono P, Garcia-Marcos M. Probing the mutational landscape of regulators of G protein signaling proteins in cancer. Sci Signal. 2020 02 04; 13(617).View Related Profiles. PMID: 32019900
     
  4. Marivin A, Maziarz M, Zhao J, DiGiacomo V, Olmos Calvo I, Mann EA, Ear J, Blanco-Canosa JB, Ross EM, Ghosh P, Garcia-Marcos M. DAPLE protein inhibits nucleotide exchange on Gas and Gaq via the same motif that activates Gai. J Biol Chem. 2020 Feb 21; 295(8):2270-2284.View Related Profiles. PMID: 31949046
     
  5. Ghosh P, Garcia-Marcos M. Do All Roads Lead to Rome in G-Protein Activation? Trends Biochem Sci. 2020 Mar; 45(3):182-184. PMID: 31753703
     
  6. Marivin A, Garcia-Marcos M. DAPLE and MPDZ bind to each other and cooperate to promote apical cell constriction. Mol Biol Cell. 2019 07 22; 30(16):1900-1910. PMID: 31268831
     
  7. Marivin A, Morozova V, Walawalkar I, Leyme A, Kretov DA, Cifuentes D, Dominguez I, Garcia-Marcos M. GPCR-independent activation of G proteins promotes apical cell constriction in vivo. J Cell Biol. 2019 05 06; 218(5):1743-1763.View Related Profiles. PMID: 30948426
     
  8. Maziarz M, Leyme A, Marivin A, Luebbers A, Patel PP, Chen Z, Sprang SR, Garcia-Marcos M. Atypical activation of the G protein Gaq by the oncogenic mutation Q209P. J Biol Chem. 2018 12 21; 293(51):19586-19599.View Related Profiles. PMID: 30352874
     
  9. Maziarz M, Broselid S, DiGiacomo V, Park JC, Luebbers A, Garcia-Navarrete L, Blanco-Canosa JB, Baillie GS, Garcia-Marcos M. A biochemical and genetic discovery pipeline identifies PLCd4b as a nonreceptor activator of heterotrimeric G-proteins. J Biol Chem. 2018 11 02; 293(44):16964-16983.View Related Profiles. PMID: 30194280
     
  10. Martemyanov KA, Garcia-Marcos M. Making useful gadgets with miniaturized G proteins. J Biol Chem. 2018 05 11; 293(19):7474-7475. PMID: 29752421
     
Showing 10 of 55 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 55 publications over 17 distinct years, with a maximum of 6 publications in 2011 and 2017

YearPublications
20031
20052
20064
20071
20083
20091
20104
20116
20123
20131
20143
20155
20165
20176
20183
20193
20204
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Boston MA 02118
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