Anukul T. Shenoy, PhD is an Instructor at Boston University School of Medicine in the Lab of Dr. Joseph P. Mizgerd in the Pulmonary Center since January 2022. His research focusses on understanding the crosstalk between epithelial cells and CD4 T cells in optimizing lung immunity during health and disease (infections and allergies). Dr. Shenoy received his PhD from University of Alabama at Birmingham where he worked on identifying the host-pathogen interactions during Streptococcus pneumoniae infections of the heart and the respiratory system.
2018-2022: Postdoctoral Associate, Dr. Joseph Mizgerd Lab, Pulmonary Center, Boston University School of Medicine, USA
2014-2017: PhD, Dr. Carlos Orihuela Lab, Department of Microbiology, University of Alabama at Birmingham School of Medicine, USA
2012-2014: MS, Department of Biotechnology, Ramnarain Ruia College, University of Mumbai, India
2009-2012: MS, Department of Biotechnology, Ramnarain Ruia College, University of Mumbai, India
Diversity, Equity, Inclusion and Accessibility
2021 - present: Member, BU Pulmonary Center, Committee for Operationalizing Racial Equity (CORE)
Aired May 2021: Guest, BU VitaminPhD Podcast (S4E7)- Understanding Racism in Higher Education
2021 - present: Organizer, “Scientists to Follow” seminar series with BUPC-SJF
2020 - present: Co-Founder and Organizer, BU Pulmonary Center Social Justice Forum (BUPC-SJF)
2019 - present: Member, Boston University Pulmonary Center Conference Organizing Committee
This tab shows grant data from BMC Sponsored Research. It includes:
- Grant title
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- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
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- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from BU Sponsored Research. It includes:
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data that did not automatically get imported into Profiles
from BU or BMC sources.
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from the Boston VA. We are only showing grant title, and only for people in the role of PI.
Lung epithelial cell reprogramming by CD4 T cells01/01/2022 - 12/31/2023 (PI)
NIH/National Heart, Lung, and Blood Institute1K99HL157555-01A1
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Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
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Arafa EI, Shenoy AT, Barker KA, Etesami NS, Martin IM, Lyon De Ana C, Na E, Odom CV, Goltry WN, Korkmaz FT, Wooten AK, Belkina AC, Guillon A, Forsberg EC, Jones MR, Quinton LJ, Mizgerd JP. Recruitment and training of alveolar macrophages after pneumococcal pneumonia. JCI Insight. 2022 Mar 08; 7(5).View Related Profiles. PMID: 35133985; PMCID: PMC8983128; DOI: 10.1172/jci.insight.150239;
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Na E, Allen E, Baird LA, Odom CV, Korkmaz FT, Shenoy AT, Matschulat AM, Jones MR, Kotton DN, Mizgerd JP, Varelas X, Traber KE, Quinton LJ. Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2022 Apr 01; 322(4):L550-L563.View Related Profiles. PMID: 35137631; PMCID: PMC8957336; DOI: 10.1152/ajplung.00325.2021;
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Shenoy AT, Lyon De Ana C, Barker KA, Arafa EI, Martin IMC, Mizgerd JP, Belkina AC. Comprehensive phenotyping of murine lung resident lymphocytes after recovery from pneumococcal pneumonia. Cytometry A. 2021 Dec 02.View Related Profiles. PMID: 34854229
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Shenoy AT, Lyon De Ana C, Arafa EI, Salwig I, Barker KA, Korkmaz FT, Ramanujan A, Etesami NS, Soucy AM, Martin IMC, Tilton BR, Hinds A, Goltry WN, Kathuria H, Braun T, Jones MR, Quinton LJ, Belkina AC, Mizgerd JP. Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity. Nat Commun. 2021 10 05; 12(1):5834.View Related Profiles. PMID: 34611166; PMCID: PMC8492657; DOI: 10.1038/s41467-021-26045-w;
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Odom CV, Kim Y, Burgess CL, Baird LA, Korkmaz FT, Na E, Shenoy AT, Arafa EI, Lam TT, Jones MR, Mizgerd JP, Traber KE, Quinton LJ. Liver-Dependent Lung Remodeling during Systemic Inflammation Shapes Responses to Secondary Infection. J Immunol. 2021 10 01; 207(7):1891-1902.View Related Profiles. PMID: 34470857; PMCID: PMC8631467; DOI: 10.4049/jimmunol.2100254;
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Barker KA, Etesami NS, Shenoy AT, Arafa EI, Lyon de Ana C, Smith NM, Martin IM, Goltry WN, Barron AM, Browning JL, Kathuria H, Belkina AC, Guillon A, Zhong X, Crossland NA, Jones MR, Quinton LJ, Mizgerd JP. Lung-resident memory B cells protect against bacterial pneumonia. J Clin Invest. 2021 06 01; 131(11).View Related Profiles. PMID: 34060477; PMCID: PMC8159694; DOI: 10.1172/JCI141810;
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Beno SM, Riegler AN, Gilley RP, Brissac T, Wang Y, Kruckow KL, Jadapalli JK, Wright GM, Shenoy AT, Stoner SN, Restrepo MI, Deshane JS, Halade GV, González-Juarbe N, Orihuela CJ. Inhibition of Necroptosis to Prevent Long-term Cardiac Damage During Pneumococcal Pneumonia and Invasive Disease. J Infect Dis. 2020 11 09; 222(11):1882-1893. PMID: 32492702; PMCID: PMC7896277; DOI: 10.1093/infdis/jiaa295;
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Wooten AK, Shenoy AT, Arafa EI, Akiyama H, Martin IMC, Jones MR, Quinton LJ, Gummuluru S, Bai G, Mizgerd JP. Unique Roles for Streptococcus pneumoniae Phosphodiesterase 2 in Cyclic di-AMP Catabolism and Macrophage Responses. Front Immunol. 2020; 11:554.View Related Profiles. PMID: 32300347; PMCID: PMC7145409; DOI: 10.3389/fimmu.2020.00554;
Showing 10 of 25 results.
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Guillon A, Arafa EI, Barker KA, Belkina AC, Martin I, Shenoy AT, Wooten AK, Lyon De Ana C, Dai A, Labadorf A, Hernandez Escalante J, Dooms H, Blasco H, Traber KE, Jones MR, Quinton LJ, Mizgerd JP. Pneumonia recovery reprograms the alveolar macrophage pool. JCI Insight. 2020 02 27; 5(4).View Related Profiles. PMID: 31990682; PMCID: PMC7101156; DOI: 10.1172/jci.insight.133042;
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Shenoy AT, Wasserman GA, Arafa EI, Wooten AK, Smith NMS, Martin IMC, Jones MR, Quinton LJ, Mizgerd JP. Lung CD4+ resident memory T cells remodel epithelial responses to accelerate neutrophil recruitment during pneumonia. Mucosal Immunol. 2020 03; 13(2):334-343.View Related Profiles. PMID: 31748706; PMCID: PMC7044037; DOI: 10.1038/s41385-019-0229-2;
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Shenoy AT, Beno SM, Brissac T, Bell JW, Novak L, Orihuela CJ. Severity and properties of cardiac damage caused by Streptococcus pneumoniae are strain dependent. PLoS One. 2018; 13(9):e0204032. PMID: 30216364; PMCID: PMC6138390; DOI: 10.1371/journal.pone.0204032;
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Brissac T, Shenoy AT, Patterson LA, Orihuela CJ. Cell Invasion and Pyruvate Oxidase-Derived H2O2 Are Critical for Streptococcus pneumoniae-Mediated Cardiomyocyte Killing. Infect Immun. 2018 01; 86(1). PMID: 29061707; PMCID: PMC5736805; DOI: 10.1128/IAI.00569-17;
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Anukul T Shenoy, Vandana Pradhan, Vinod Umare, Kanjaksha Ghosh. DNA methylation and silencing of gene expression role in pathogenesis of systemic lupus erythematosus. Indian Journal of Biotechnology. 2017; 16(4):521-528. View Publication
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Shenoy AT, Brissac T, Gilley RP, Kumar N, Wang Y, Gonzalez-Juarbe N, Hinkle WS, Daugherty SC, Shetty AC, Ott S, Tallon LJ, Deshane J, Tettelin H, Orihuela CJ. Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing. PLoS Pathog. 2017 Aug; 13(8):e1006582. PMID: 28841717; PMCID: PMC5589263; DOI: 10.1371/journal.ppat.1006582;
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Spencer BL, Shenoy AT, Orihuela CJ, Nahm MH. The Pneumococcal Serotype 15C Capsule Is Partially O-Acetylated and Allows for Limited Evasion of 23-Valent Pneumococcal Polysaccharide Vaccine-Elicited Anti-Serotype 15B Antibodies. Clin Vaccine Immunol. 2017 Aug; 24(8). PMID: 28637806; PMCID: PMC5583466; DOI: 10.1128/CVI.00099-17;
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Spencer BL, Saad JS, Shenoy AT, Orihuela CJ, Nahm MH. Position of O-Acetylation within the Capsular Repeat Unit Impacts the Biological Properties of Pneumococcal Serotypes 33A and 33F. Infect Immun. 2017 07; 85(7). PMID: 28438972; PMCID: PMC5478959; DOI: 10.1128/IAI.00132-17;
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Lizcano A, Akula Suresh Babu R, Shenoy AT, Saville AM, Kumar N, D'Mello A, Hinojosa CA, Gilley RP, Segovia J, Mitchell TJ, Tettelin H, Orihuela CJ. Transcriptional organization of pneumococcal psrP-secY2A2 and impact of GtfA and GtfB deletion on PsrP-associated virulence properties. Microbes Infect. 2017 06; 19(6):323-333. PMID: 28408270; PMCID: PMC5581956; DOI: 10.1016/j.micinf.2017.04.001;
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González-Juarbe N, Bradley KM, Shenoy AT, Gilley RP, Reyes LF, Hinojosa CA, Restrepo MI, Dube PH, Bergman MA, Orihuela CJ. Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia. Cell Death Differ. 2017 05; 24(5):917-928. PMID: 28387756; PMCID: PMC5423117; DOI: 10.1038/cdd.2017.49;
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Ray C, Shenoy AT, Orihuela CJ, González-Juarbe N. Killing of Serratia marcescens biofilms with chloramphenicol. Ann Clin Microbiol Antimicrob. 2017 Mar 29; 16(1):19. PMID: 28356113; PMCID: PMC5370475; DOI: 10.1186/s12941-017-0192-2;
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Reyes LF, Restrepo MI, Hinojosa CA, Soni NJ, Shenoy AT, Gilley RP, Gonzalez-Juarbe N, Noda JR, Winter VT, de la Garza MA, Shade RE, Coalson JJ, Giavedoni LD, Anzueto A, Orihuela CJ. A Non-Human Primate Model of Severe Pneumococcal Pneumonia. PLoS One. 2016; 11(11):e0166092. PMID: 27855182
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Blanchette KA, Shenoy AT, Milner J, Gilley RP, McClure E, Hinojosa CA, Kumar N, Daugherty SC, Tallon LJ, Ott S, King SJ, Ferreira DM, Gordon SB, Tettelin H, Orihuela CJ. Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization. Infect Immun. 2016 10; 84(10):2922-32. PMID: 27481242
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Shenoy AT, Orihuela CJ. Anatomical site-specific contributions of pneumococcal virulence determinants. Pneumonia (Nathan). 2016; 8. PMID: 27635368
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Gilley RP, González-Juarbe N, Shenoy AT, Reyes LF, Dube PH, Restrepo MI, Orihuela CJ. Infiltrated Macrophages Die of Pneumolysin-Mediated Necroptosis following Pneumococcal Myocardial Invasion. Infect Immun. 2016 05; 84(5):1457-69. PMID: 26930705
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
| Year | Publications |
|---|
| 2016 | 4 |
| 2017 | 8 |
| 2018 | 1 |
| 2019 | 1 |
| 2020 | 3 |
| 2021 | 6 |
| 2022 | 2 |
2021 Intersections Science Fellowship Symposium (ISFS):
Inaugural Intersections Science (ISFS) Associate for January 2021
2021 The American Thoracic Society:
The American Thoracic Society 2021 Abstract Scholarship
2021 The American Thoracic Society:
ATS Allergy, Immunology & Inflammation Science and Innovation Center Award
2021 The American Association of Immunologists:
The American Association of Immunologists 2021 Trainee Abstract Award
2021 Intersections Science Fellowship Symposium (ISFS):
Intersections Science (ISFS) Associate for November 2021
2021 The American Association of Immunologists:
The American Association of Immunologists Young Investigator Award
2019 The American Thoracic Society:
The American Thoracic Society 2019 Abstract Scholarship
2019 BU Dept. Of Medicine:
Second Place- Basic Science Poster
2018 BU Dept. Of Medicine:
Second Place- Basic Science Talk
2017 UAB Dept. of Microbiology :
David E. Wells Symposium Graduate Student Speaker
2017 The UAB Comprehensive Cardiovascular Center :
The UAB Comprehensive Cardiovascular Center Travel Award
2017 UAB Dept. of Microbiology:
The Hiramoto Travel Award
2016 The American Society for Microbiology:
The Richard and Mary Finkelstein Student Travel Grant
2015-2017 UAB Dept. of Microbiology:
Gail H. Cassell Microbiology Scholarship Endowment Award
2013 Ramnarain Ruia College :
Smt. Yamunabai Hirlekar Award
2012-2014 Sir Ratan Tata Trust :
Sir Ratan Tata Trust National Merit Scholarship
2011 Ramnarain Ruia College :
Kridabhushan Award for Sports Excellence
2010 Ramnarain Ruia College of Science Alumni Association:
Ramnarain Ruia College of Science Alumni Association Best Student Award
2009-2014 The University of Mumbai :
Late Smt. Gunwantiben K. Mehta Award