I am a NIH/NHLBI K99/R00 Fellow, an Intersections Science (ISFS) Associate 2021 and Instructor of Medicine at the Pulmonary Center in Boston University School of Medicine with research interests focused on understanding how lung epithelial cells act as critical coordinators of lung immunity during health and disease. Before I picked up pipettes and syringes, I was a competitive swimmer and a student-athlete in India.
?I was born on October 25th 1991 to the International Marathon Swimming Hall of Fame inductee Padmashri Taranath N. Shenoy and Mrs. Sarojini Shenoy in Mumbai, India. Born to a swimming legend, I quickly took to the water and started competing by the age of 4 years. Between ages of 4 and 22, trained and nurtured by my parents, I competed in numerous local, state and national level swimming (both short distance and open water) and waterpolo tournaments and accrued over 450 medals with 39 meet records and >50 overall championships.
As I worked my way through schooling from Sharon English High School, Mulund, Mumbai, I took a liking to academics and discovered my passion for science. After I was ranked as the top scoring student-athlete across Maharashtra state in the Secondary School Certificate exams of 2007, I decided to focus majority of my time and attention towards academics while juggling competitive swimming and a passion for soccer. Drawn to the biological sciences, I received my Higher Secondary School Certificate in the field of Science in 2009 from KET's V.G. Vaze College of Science before going on to complete my BS and MS in Biotechnology from Ramnarain Ruia College of Sciences in 2012 and 2014, respectively. I continued to lead my school swimming teams to inter-collegiate championships as a student athlete while doing so.
In July 2014, I embarked on a voyage to USA in pursuit of my dream of performing research in Microbiology and Immunology. I started my PhD work in the lab of Dr. Carlos J. Orihuela at University of Texas Health San Antonio before moving with Dr. Orihuela to The University of Alabama at Birmingham (in 2015) where I worked on identifying the host-pathogen interactions during Streptococcus pneumoniae infections. My doctoral work was focussed on elucidating the molecular mechanisms by which S. pneumoniae evades inflammation within the heart during invasive pneumococcal disease. After receiving my PhD in 2017, I began my postdoctoral work in the Pneumonia Biology labs with Dr. Joseph P. Mizgerd at the Pulmonary Center in Boston University School of Medicine. My current research interests are focussed on understanding the crosstalk between distinct lung epithelial cells and lung resident CD4+ T cells in context of infection, inflammation, allergy and immunity. Mentored by Drs. Orihuela and Mizgerd, I have published primary research articles in respected journals like Nature Communications, Mucosal Immunology, PLOS Pathogens, Journal of Infectious Diseases, JCI Insights among many others and have presented my work at numerous international conferences. Excellent mentorship in addition to my humble childhood upbringing that prioritized dreaming, hard work, persistence and thirst for excellence have served me well even in my academic training, and I have been the recipient of multiple institutional and scientific society honors/awards as a research trainee (see achievements).
As a scientist, my goal is to perform the most exciting, ground breaking and out-of-the-box science and on the way create new knowledge at the frontiers of biomedical research. I see my job as a unique opportunity to identify and fit distinct pieces of an intricate puzzle laid out to us by evolution.
Diversity, Equity, Inclusion and Accessibility
2021 - present: Member, BU Pulmonary Center, Committee for Operationalizing Racial Equity (CORE)
Aired May 2021: Guest, BU VitaminPhD Podcast (S4E7)- Understanding Racism in Higher Education
2021 - present: Organizer, “Scientists to Follow” seminar series with BUPC-SJF
2020 - present: Co-Founder and Organizer, BU Pulmonary Center Social Justice Forum (BUPC-SJF)
2019 - present: Member, Boston University Pulmonary Center Conference Organizing Committee
This tab shows grant data from BMC Sponsored Research. It includes:
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- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from BU Sponsored Research. It includes:
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data that did not automatically get imported into Profiles
from BU or BMC sources.
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from the Boston VA. We are only showing grant title, and only for people in the role of PI.
Lung epithelial cell reprogramming by CD4 T cells01/01/2022 - 12/31/2023 (PI)
NIH/National Heart, Lung, and Blood Institute1K99HL157555-01A1
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Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
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to make corrections and additions.
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Arafa EI, Shenoy AT, Barker KA, Etesami NS, Martin IM, Lyon De Ana C, Na E, Odom CV, Goltry WN, Korkmaz FT, Wooten AK, Belkina AC, Guillon A, Forsberg EC, Jones MR, Quinton LJ, Mizgerd JP. Recruitment and training of alveolar macrophages after pneumococcal pneumonia. JCI Insight. 2022 Mar 08; 7(5).View Related Profiles. PMID: 35133985; DOI: 10.1172/jci.insight.150239;
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Na E, Allen E, Baird LA, Odom CV, Korkmaz FT, Shenoy AT, Matschulat AM, Jones MR, Kotton DN, Mizgerd JP, Varelas X, Traber KE, Quinton LJ. Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2022 Apr 01; 322(4):L550-L563.View Related Profiles. PMID: 35137631; DOI: 10.1152/ajplung.00325.2021;
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Shenoy AT, Lyon De Ana C, Barker KA, Arafa EI, Martin IMC, Mizgerd JP, Belkina AC. Comprehensive phenotyping of murine lung resident lymphocytes after recovery from pneumococcal pneumonia. Cytometry A. 2021 Dec 02.View Related Profiles. PMID: 34854229; DOI: 10.1002/cyto.a.24522;
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Shenoy AT, Lyon De Ana C, Arafa EI, Salwig I, Barker KA, Korkmaz FT, Ramanujan A, Etesami NS, Soucy AM, Martin IMC, Tilton BR, Hinds A, Goltry WN, Kathuria H, Braun T, Jones MR, Quinton LJ, Belkina AC, Mizgerd JP. Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity. Nat Commun. 2021 10 05; 12(1):5834.View Related Profiles. PMID: 34611166; DOI: 10.1038/s41467-021-26045-w;
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Odom CV, Kim Y, Burgess CL, Baird LA, Korkmaz FT, Na E, Shenoy AT, Arafa EI, Lam TT, Jones MR, Mizgerd JP, Traber KE, Quinton LJ. Liver-Dependent Lung Remodeling during Systemic Inflammation Shapes Responses to Secondary Infection. J Immunol. 2021 10 01; 207(7):1891-1902.View Related Profiles. PMID: 34470857; DOI: 10.4049/jimmunol.2100254;
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Barker KA, Etesami NS, Shenoy AT, Arafa EI, Lyon de Ana C, Smith NM, Martin IM, Goltry WN, Barron AM, Browning JL, Kathuria H, Belkina AC, Guillon A, Zhong X, Crossland NA, Jones MR, Quinton LJ, Mizgerd JP. Lung-resident memory B cells protect against bacterial pneumonia. J Clin Invest. 2021 06 01; 131(11).View Related Profiles. PMID: 34060477; DOI: 10.1172/JCI141810;
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Traber KE, Dimbo EL, Shenoy AT, Symer EM, Allen E, Mizgerd JP, Quinton LJ. Neutrophil-Derived Oncostatin M Triggers Diverse Signaling Pathways during Pneumonia. Infect Immun. 2021 03 17; 89(4).View Related Profiles. PMID: 33526570; DOI: 10.1128/IAI.00655-20;
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Beno SM, Riegler AN, Gilley RP, Brissac T, Wang Y, Kruckow KL, Jadapalli JK, Wright GM, Shenoy AT, Stoner SN, Restrepo MI, Deshane JS, Halade GV, González-Juarbe N, Orihuela CJ. Inhibition of Necroptosis to Prevent Long-term Cardiac Damage During Pneumococcal Pneumonia and Invasive Disease. J Infect Dis. 2020 11 09; 222(11):1882-1893. PMID: 32492702; DOI: 10.1093/infdis/jiaa295;
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Wooten AK, Shenoy AT, Arafa EI, Akiyama H, Martin IMC, Jones MR, Quinton LJ, Gummuluru S, Bai G, Mizgerd JP. Unique Roles for Streptococcus pneumoniae Phosphodiesterase 2 in Cyclic di-AMP Catabolism and Macrophage Responses. Front Immunol. 2020; 11:554.View Related Profiles. PMID: 32300347; DOI: 10.3389/fimmu.2020.00554;
Showing 10 of 25 results.
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Guillon A, Arafa EI, Barker KA, Belkina AC, Martin I, Shenoy AT, Wooten AK, Lyon De Ana C, Dai A, Labadorf A, Hernandez Escalante J, Dooms H, Blasco H, Traber KE, Jones MR, Quinton LJ, Mizgerd JP. Pneumonia recovery reprograms the alveolar macrophage pool. JCI Insight. 2020 02 27; 5(4).View Related Profiles. PMID: 31990682; DOI: 10.1172/jci.insight.133042;
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Shenoy AT, Wasserman GA, Arafa EI, Wooten AK, Smith NMS, Martin IMC, Jones MR, Quinton LJ, Mizgerd JP. Lung CD4+ resident memory T cells remodel epithelial responses to accelerate neutrophil recruitment during pneumonia. Mucosal Immunol. 2020 03; 13(2):334-343.View Related Profiles. PMID: 31748706; DOI: 10.1038/s41385-019-0229-2;
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Shenoy AT, Beno SM, Brissac T, Bell JW, Novak L, Orihuela CJ. Severity and properties of cardiac damage caused by Streptococcus pneumoniae are strain dependent. PLoS One. 2018; 13(9):e0204032. PMID: 30216364; DOI: 10.1371/journal.pone.0204032;
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Brissac T, Shenoy AT, Patterson LA, Orihuela CJ. Cell Invasion and Pyruvate Oxidase-Derived H2O2 Are Critical for Streptococcus pneumoniae-Mediated Cardiomyocyte Killing. Infect Immun. 2018 01; 86(1). PMID: 29061707; DOI: 10.1128/IAI.00569-17;
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Anukul T Shenoy, Vandana Pradhan, Vinod Umare, Kanjaksha Ghosh. DNA methylation and silencing of gene expression role in pathogenesis of systemic lupus erythematosus. Indian Journal of Biotechnology. 2017; 16(4):521-528. View Publication
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Shenoy AT, Brissac T, Gilley RP, Kumar N, Wang Y, Gonzalez-Juarbe N, Hinkle WS, Daugherty SC, Shetty AC, Ott S, Tallon LJ, Deshane J, Tettelin H, Orihuela CJ. Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing. PLoS Pathog. 2017 Aug; 13(8):e1006582. PMID: 28841717; DOI: 10.1371/journal.ppat.1006582;
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Spencer BL, Shenoy AT, Orihuela CJ, Nahm MH. The Pneumococcal Serotype 15C Capsule Is Partially O-Acetylated and Allows for Limited Evasion of 23-Valent Pneumococcal Polysaccharide Vaccine-Elicited Anti-Serotype 15B Antibodies. Clin Vaccine Immunol. 2017 Aug; 24(8). PMID: 28637806; DOI: 10.1128/CVI.00099-17;
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Spencer BL, Saad JS, Shenoy AT, Orihuela CJ, Nahm MH. Position of O-Acetylation within the Capsular Repeat Unit Impacts the Biological Properties of Pneumococcal Serotypes 33A and 33F. Infect Immun. 2017 07; 85(7). PMID: 28438972; DOI: 10.1128/IAI.00132-17;
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Lizcano A, Akula Suresh Babu R, Shenoy AT, Saville AM, Kumar N, D'Mello A, Hinojosa CA, Gilley RP, Segovia J, Mitchell TJ, Tettelin H, Orihuela CJ. Transcriptional organization of pneumococcal psrP-secY2A2 and impact of GtfA and GtfB deletion on PsrP-associated virulence properties. Microbes Infect. 2017 06; 19(6):323-333. PMID: 28408270; DOI: 10.1016/j.micinf.2017.04.001;
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González-Juarbe N, Bradley KM, Shenoy AT, Gilley RP, Reyes LF, Hinojosa CA, Restrepo MI, Dube PH, Bergman MA, Orihuela CJ. Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia. Cell Death Differ. 2017 05; 24(5):917-928. PMID: 28387756; DOI: 10.1038/cdd.2017.49;
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Ray C, Shenoy AT, Orihuela CJ, González-Juarbe N. Killing of Serratia marcescens biofilms with chloramphenicol. Ann Clin Microbiol Antimicrob. 2017 Mar 29; 16(1):19. PMID: 28356113; DOI: 10.1186/s12941-017-0192-2;
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Reyes LF, Restrepo MI, Hinojosa CA, Soni NJ, Shenoy AT, Gilley RP, Gonzalez-Juarbe N, Noda JR, Winter VT, de la Garza MA, Shade RE, Coalson JJ, Giavedoni LD, Anzueto A, Orihuela CJ. A Non-Human Primate Model of Severe Pneumococcal Pneumonia. PLoS One. 2016; 11(11):e0166092. PMID: 27855182
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Blanchette KA, Shenoy AT, Milner J, Gilley RP, McClure E, Hinojosa CA, Kumar N, Daugherty SC, Tallon LJ, Ott S, King SJ, Ferreira DM, Gordon SB, Tettelin H, Orihuela CJ. Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization. Infect Immun. 2016 10; 84(10):2922-32. PMID: 27481242
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Shenoy AT, Orihuela CJ. Anatomical site-specific contributions of pneumococcal virulence determinants. Pneumonia (Nathan). 2016; 8. PMID: 27635368
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Gilley RP, González-Juarbe N, Shenoy AT, Reyes LF, Dube PH, Restrepo MI, Orihuela CJ. Infiltrated Macrophages Die of Pneumolysin-Mediated Necroptosis following Pneumococcal Myocardial Invasion. Infect Immun. 2016 05; 84(5):1457-69. PMID: 26930705
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
| Year | Publications |
|---|
| 2016 | 4 |
| 2017 | 8 |
| 2018 | 1 |
| 2019 | 1 |
| 2020 | 3 |
| 2021 | 6 |
| 2022 | 2 |
2021 Intersections Science Fellowship Symposium (ISFS):
Inaugural Intersections Science (ISFS) Associate for January 2021
2021 The American Thoracic Society:
The American Thoracic Society 2021 Abstract Scholarship
2021 The American Thoracic Society:
ATS Allergy, Immunology & Inflammation Science and Innovation Center Award
2021 The American Association of Immunologists:
The American Association of Immunologists 2021 Trainee Abstract Award
2021 Intersections Science Fellowship Symposium (ISFS):
Intersections Science (ISFS) Associate for November 2021
2021 The American Association of Immunologists:
The American Association of Immunologists Young Investigator Award
2019 The American Thoracic Society:
The American Thoracic Society 2019 Abstract Scholarship
2019 BU Dept. Of Medicine:
Second Place- Basic Science Poster
2018 BU Dept. Of Medicine:
Second Place- Basic Science Talk
2017 UAB Dept. of Microbiology :
David E. Wells Symposium Graduate Student Speaker
2017 The UAB Comprehensive Cardiovascular Center :
The UAB Comprehensive Cardiovascular Center Travel Award
2017 UAB Dept. of Microbiology:
The Hiramoto Travel Award
2016 The American Society for Microbiology:
The Richard and Mary Finkelstein Student Travel Grant
2015-2017 UAB Dept. of Microbiology:
Gail H. Cassell Microbiology Scholarship Endowment Award
2013 Ramnarain Ruia College :
Smt. Yamunabai Hirlekar Award
2012-2014 Sir Ratan Tata Trust :
Sir Ratan Tata Trust National Merit Scholarship
2011 Ramnarain Ruia College :
Kridabhushan Award for Sports Excellence
2010 Ramnarain Ruia College of Science Alumni Association:
Ramnarain Ruia College of Science Alumni Association Best Student Award
2009-2014 The University of Mumbai :
Late Smt. Gunwantiben K. Mehta Award