Stefano Monti, PhD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Computational Biomedicine

PhD, University of Pittsburgh
MS, University of Pittsburgh
MS, University of Houston




Stefano Monti is a Computational Biologist and joined the BU faculty in January 2011 in the section of Computational Biomedicine, with joint appointments in the Biostatistics Department and the Bioinformatics program. Monti received his Ph.D. in Intelligent Systems and Artificial Intelligence from the University of Pittsburgh, and completed his training with a post-doctoral fellowship at the Robotics Institute at Carnegie Mellon. His doctoral and post-doctoral research focused on the development of machine learning and knowledge discovery methodologies, with a particular emphasis on probabilistic reasoning and Bayesian approaches to modeling biomedical data. Since 2001, he has worked in the field of Cancer Genomics, first as a Research Scientist at the Whitehead Institute’s Center for Genome Research, and later as a Computational Biologist in the Cancer Program at the Broad Institute.

Dr. Monti's laboratory integrates systems biology, machine learning, and bioinformatics approaches to investigate the molecular drivers of human disease, with the goals of advancing prevention and care. This multidisciplinary effort relies on the development of novel computational methodologies, and on the design of experiments based on the generation and integrative analysis of high-throughput multi-omics data, with the goal of identifying novel therapeutic targets and developing accurate diagnostic and prognostic biomarkers. Specific areas of research include the study of the molecular mechanisms of tumor initiation and progression and of the role played in it by environmental exposure, as well as the study of the biological factors contributing to healthy aging and extreme longevity.

Associate Professor
Boston University School of Public Health
Biostatistics


Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Bioinformatics Graduate Program


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Defining the Beta-catenin/CBP axis in head and neck cancer
12/07/2020 - 11/30/2025 (Multi-PI)
PI: Stefano Monti, PhD
NIH/National Institute of Dental & Craniofacial Research
5R01DE030350-02

Multiscale analysis of metabolic inflammation as a driver of breast cancer
09/09/2020 - 08/31/2025 (Multi-PI)
PI: Stefano Monti, PhD
NIH/National Cancer Institute
5U01CA243004-02

System-Level Analyses of Multi-Omics Data to Reveal Mechanisms of Head & Neck Cancer
03/17/2022 - 01/31/2025 (PI)
NIH/National Institute of Dental & Craniofacial Research
1R01DE031831-01

Intercepting head and neck cancer using functional genomics approaches
09/01/2020 - 08/31/2023 (Key Person / Mentor)
NIH/National Institute of Dental & Craniofacial Research
5F31DE029701-02

Metabolic Pathways of Increased Cardiovascular risk in type 2 Diabetes
04/01/2016 - 02/29/2020 (Subcontract PI)
Joslin Diabetes Center NIH NHLBI
5R01HL132254-04

Novel genomic models to predict breast carcinogenicity of environmental chemicals
10/01/2014 - 09/30/2016 (PI)
Art beCAUSE


Lymphoma Target Testing Center
07/01/2013 - 06/30/2016 (Subcontract PI)
Dana-Farber Cancer Institute Paul E. Singer Fdn


Receptor-based Developmental and Reproductive Toxicity of Superfund Chemicals
09/20/2012 - 03/31/2016 (Co-Investigator)
PI: David H. Sherr, PhD
NIH/National Institute of Environmental Health Sciences
5P42ES007381-19

Targeting Genetically-driven p53 and Cell Cycle Deregulation in DLBCL
10/01/2012 - 09/30/2015 (Subcontract PI)
Dana-Farber Cancer Institute Leukemia & Lymph Soc




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Shah HS, Moreno LO, Morieri ML, Tang Y, Mendonca C, Jobe JM, Thacker JB, Mitri J, Monti S, Niewczas MA, Pennathur S, Doria A. Serum Orotidine: A Novel Biomarker of Increased CVD Risk in Type 2 Diabetes Discovered Through Metabolomics Studies. Diabetes Care. 2022 Aug 01; 45(8):1882-1892. PMID: 35696261; PMCID: PMC9346986; DOI: 10.2337/dc21-1789;
     
  2. Alhousami T, Diny M, Ali F, Shin J, Kumar G, Kumar V, Campbell JD, Noonan V, Hanna GJ, Denis GV, Monti S, Kukuruzinska MA, Varelas X, Bais MV. Inhibition of LSD1 Attenuates Oral Cancer Development and Promotes Therapeutic Efficacy of Immune Checkpoint Blockade and YAP/TAZ Inhibition. Mol Cancer Res. 2022 May 04; 20(5):712-721.View Related Profiles. PMID: 35105672; PMCID: PMC9081163; DOI: 10.1158/1541-7786.MCR-21-0310;
     
  3. Karagiannis TT, Monti S, Sebastiani P. Cell Type Diversity Statistic: An Entropy-Based Metric to Compare Overall Cell Type Composition Across Samples. Front Genet. 2022; 13:855076.View Related Profiles. PMID: 35464841; PMCID: PMC9023789; DOI: 10.3389/fgene.2022.855076;
     
  4. Reed ER, Monti S. Multi-resolution characterization of molecular taxonomies in bulk and single-cell transcriptomics data. Nucleic Acids Res. 2021 09 27; 49(17):e98.View Related Profiles. PMID: 34226941; PMCID: PMC8464061; DOI: 10.1093/nar/gkab552;
     
  5. Gurinovich A, Song Z, Zhang W, Federico A, Monti S, Andersen SL, Jennings LL, Glass DJ, Barzilai N, Millman S, Perls TT, Sebastiani P. Correction to: Effect of longevity genetic variants on the molecular aging rate. Geroscience. 2021 Aug; 43(4):2101.View Related Profiles. PMID: 34143375; PMCID: PMC8492867; DOI: 10.1007/s11357-021-00400-7;
     
  6. Kim S, Reed E, Monti S, Schlezinger JJ. A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify White and Brite Adipogens. Environ Health Perspect. 2021 07; 129(7):77006.View Related Profiles. PMID: 34323617; PMCID: PMC8320370; DOI: 10.1289/EHP6886;
     
  7. Hicks-Berthet J, Ning B, Federico A, Tilston-Lunel A, Matschulat A, Ai X, Lenburg ME, Beane J, Monti S, Varelas X. Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis. Cell Rep. 2021 07 13; 36(2):109347.View Related Profiles. PMID: 34260916; PMCID: PMC8346236; DOI: 10.1016/j.celrep.2021.109347;
     
  8. Dela Cruz A, Kartha V, Tilston-Lunel A, Mi R, Reynolds TL, Mingueneau M, Monti S, Jensen JL, Skarstein K, Varelas X, Kukuruzinska MA. Gene expression alterations in salivary gland epithelia of Sjögren's syndrome patients are associated with clinical and histopathological manifestations. Sci Rep. 2021 05 27; 11(1):11154.View Related Profiles. PMID: 34045583; PMCID: PMC8159963; DOI: 10.1038/s41598-021-90569-w;
     
  9. Gurinovich A, Song Z, Zhang W, Federico A, Monti S, Andersen SL, Jennings LL, Glass DJ, Barzilai N, Millman S, Perls TT, Sebastiani P. Effect of longevity genetic variants on the molecular aging rate. Geroscience. 2021 06; 43(3):1237-1251.View Related Profiles. PMID: 33948810; PMCID: PMC8190315; DOI: 10.1007/s11357-021-00376-4;
     
  10. Zhao Y, Federico A, Faits T, Manimaran S, Segrè D, Monti S, Johnson WE. animalcules: interactive microbiome analytics and visualization in R. Microbiome. 2021 03 28; 9(1):76.View Related Profiles. PMID: 33775256; PMCID: PMC8006385; DOI: 10.1186/s40168-021-01013-0;
     
Showing 10 of 121 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 117 publications over 28 distinct years, with a maximum of 11 publications in 2021

YearPublications
19951
19961
19972
19982
19992
20001
20011
20021
20032
20042
20052
20067
20076
20083
20091
20102
20115
20124
20137
20146
20156
201610
20177
20187
20198
20207
202111
20223

Available to Mentor as: (Review Mentor Role Definitions):
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  • Co-Mentor or Peer Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

75 E. Newton St Evans Building
Boston MA 02118
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