Stefano Monti, PhD Hear my name
Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Computational Biomedicine

PhD, University of Pittsburgh
MS, University of Pittsburgh
MS, University of Houston
BS, Università degli Studi di Udine

Pronouns: he/him/his



Stefano Monti is a Computational Biologist and joined the BU faculty in January 2011 in the section of Computational Biomedicine, with joint appointments in the Biostatistics Department and the Bioinformatics program. Monti received his Ph.D. in Intelligent Systems and Artificial Intelligence from the University of Pittsburgh, and completed his training with a post-doctoral fellowship at the Robotics Institute at Carnegie Mellon. His doctoral and post-doctoral research focused on the development of machine learning and knowledge discovery methodologies, with a particular emphasis on probabilistic reasoning and Bayesian approaches to modeling biomedical data. Since 2001, he has worked in the field of Cancer Genomics, first as a Research Scientist at the Whitehead Institute’s Center for Genome Research, and later as a Computational Biologist in the Cancer Program at the Broad Institute.

Dr. Monti's laboratory integrates systems biology, machine learning, and bioinformatics approaches to investigate the molecular drivers of human disease, with the goals of advancing prevention and care. This multidisciplinary effort relies on the development of novel computational methodologies, and on the design of experiments based on the generation and integrative analysis of high-throughput multi-omics data, with the goal of identifying novel therapeutic targets and developing accurate diagnostic and prognostic biomarkers. Specific areas of research include the study of the molecular mechanisms of tumor initiation and progression and of the role played in it by environmental exposure, as well as the study of the biological factors contributing to healthy aging and extreme longevity.

Associate Professor
Boston University School of Public Health
Biostatistics


Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Bioinformatics Graduate Program


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Defining immune-evasive mechanical signaling in head and neck cancer
06/06/2024 - 03/31/2029 (Multi PI of Sub-Project / SP)
PI: Xaralabos Varelas, PhD
NIH/National Institute of Dental & Craniofacial Research
5R01DE033519-02

Elucidating mechanisms of cellular communication critical for head and neck cancer progression and metastasis.
11/01/2023 - 10/31/2026 (Key Person / Mentor)
NIH/National Institute of Dental & Craniofacial Research
5F31DE033292-02

System-Level Analyses of Multi-Omics Data to Reveal Mechanisms of Head & Neck Cancer
03/17/2022 - 01/31/2026 (PI)
NIH/National Institute of Dental & Craniofacial Research
5R01DE031831-03

Defining the Beta-catenin/CBP axis in head and neck cancer
12/07/2020 - 11/30/2025 (Multi-PI)
PI: Stefano Monti, PhD
NIH/National Institute of Dental & Craniofacial Research
5R01DE030350-05

Longevity Consortium - Integrative Analysis Core
09/30/2024 - 08/31/2025 (Multi-PI)
PI: Stefano Monti, PhD
The Translational Genomics Research Institute NIH NIA
2U19AG023122-16

Extreme Longevity, Cognitive Aging and Alzheimer’s Disease and Related Dementias
09/30/2024 - 08/31/2025 (PI of Sub-Project / SP)
The Translational Genomics Research Institute NIH NIA
2U19AG023122-16

Multiscale analysis of metabolic inflammation as a driver of breast cancer
09/09/2020 - 08/31/2025 (Multi-PI)
PI: Stefano Monti, PhD
NIH/National Cancer Institute
5U01CA243004-05

Longevity Consortium: The role of molecular damage in muscle for muscle performance with aging
06/01/2022 - 09/29/2024 (Subcontract PI)
Sutter Bay Hospitals dba California Pacific Medical Center NIH NIA
5U19AG023122-15

Intercepting head and neck cancer using functional genomics approaches
09/01/2020 - 08/31/2022 (Key Person / Mentor)
NIH/National Institute of Dental & Craniofacial Research
5F31DE029701-02

Metabolic Pathways of Increased Cardiovascular risk in type 2 Diabetes
04/01/2016 - 02/29/2020 (Subcontract PI)
Joslin Diabetes Center NIH NHLBI
5R01HL132254-04

Showing 10 of 14 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Website       Copy PMIDs To Clipboard

  1. Chakraborty AK, Kroehling L, Raut RD, Choudhury C, Kukuruzinska MA, Gutkind JS, Varelas X, Sahay B, Monti S, Bais MV. LSD1 Inhibition Induces MHC-I and Dendritic Cell Activation to Promote Antitumor Immunity in Head and Neck Squamous Cell Carcinoma. Cancer Res. 2025 Oct 09.View Related Profiles. PMID: 41066547; DOI: 10.1158/0008-5472.CAN-24-3239;
     
  2. Ennis CS, Seen M, Chen A, Kang H, Ilinski A, Mahdaviani K, Ko NY, Monti S, Denis GV. Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids. Commun Biol. 2025 Aug 26; 8(1):1276.View Related Profiles. PMID: 40858992; PMCID: PMC12381303; DOI: 10.1038/s42003-025-08663-y;
     
  3. Li M, Song Z, Reed E, Karagiannis TT, Andersen S, Brent M, Mateusiak C, Acharya S, Jung WS, Liao S, Wojczynski MK, Feitosa MF, O'Connell JR, Montasser ME, Thorpe RJ, Arbeev K, Milman S, Tai A, Perls TT, Sebastiani P, Monti S. Whole blood transcriptional signatures of age and survival identified in Long Life Family and Integrative Longevity Omics Studies. bioRxiv. 2025 Jul 18.View Related Profiles. PMID: 40791342; PMCID: PMC12338699; DOI: 10.1101/2025.07.15.664976;
     
  4. Llévenes P, Chen A, Lawton M, Rondón-Ortiz AN, Qiu Y, Seen M, Monti S, Denis GV. Plasma exosomes in insulin resistant obesity exacerbate progression of triple negative breast cancer. BMC Cancer. 2025 Jul 09; 25(1):1089.View Related Profiles. PMID: 40629272; PMCID: PMC12239313; DOI: 10.1186/s12885-025-14447-8;
     
  5. Li W, Nishino M, Reed E, Akshinthala D, Pasha HA, Anderson ES, Huang L, Hebestreit H, Monti S, Gomez ED, Jalisi SM, Muthuswamy SK. Head and neck tumor organoid grown under simplified media conditions model tumor biology and chemoradiation responses. Sci Rep. 2025 Jul 07; 15(1):24221. PMID: 40624315; PMCID: PMC12234821; DOI: 10.1038/s41598-025-88082-5;
     
  6. Trepicchio C, Rauner G, Traugh N, Wang R, Parrish M, Fein DEC, Mal Y, Gupta PB, Monti S, Kuperwasser C. DDR1 regulates RUNX1-CBFß to control breast stem cell differentiation. Stem Cell Reports. 2025 Aug 12; 20(8):102576. PMID: 40614729; PMCID: PMC12365826; DOI: 10.1016/j.stemcr.2025.102576;
     
  7. Song Z, Gunn S, Monti S, Peloso GM, Liu CT, Lunetta K, Sebastiani P. Learning Gaussian Graphical Models from Correlated Data. Front Syst Biol. 2025; 5.View Related Profiles. PMID: 40766210; PMCID: PMC12323441; DOI: 10.3389/fsysb.2025.1589079;
     
  8. Qiu Y, Chen A, Yu R, Llevenes P, Seen M, Ko NY, Monti S, Denis GV. Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-Derived Exosomes. Mol Cancer Res. 2025 Jun 03; 23(6):567-578.View Related Profiles. PMID: 40047645; PMCID: PMC12133429; DOI: 10.1158/1541-7786.MCR-24-0494;
     
  9. Sebastiani P, Reed E, Chandler KB, Lopez P, Lords H, Bae H, Costello CE, Au M, Deng LL, Li M, Xiang Q, Noh H, Pflieger L, Funk C, Rappaport N, Nygaard M, Short MI, Brent M, Monti S, Andersen SL, Perls TT. Robust Serum Proteomic Signatures of APOE2. bioRxiv. 2025 May 28.View Related Profiles. PMID: 40501769; PMCID: PMC12154932; DOI: 10.1101/2025.05.24.655950;
     
  10. Shastry A, Hiller BE, Sanders NL, Tseng AE, Kothari J, O'Connell AK, Gertje HP, Ha CT, Murzin E, Traber KE, Lederer JA, Jones MR, Douam F, Beach TG, Remick DG, Crossland NA, Monti S, Campbell JD, Mizgerd JP. Sub-phenotypes of pneumonia defined by pulmonary histopathological features. bioRxiv. 2025 May 20.View Related Profiles. PMID: 40475544; PMCID: PMC12139937; DOI: 10.1101/2025.05.18.654716;
     
Showing 10 of 161 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 157 publications over 31 distinct years, with a maximum of 16 publications in 2025

YearPublications
19951
19961
19972
19982
19992
20001
20011
20021
20032
20042
20052
20067
20076
20083
20091
20102
20115
20124
20137
20146
20156
201610
20177
20189
20198
20207
202111
20226
20238
202411
202516

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Making breakthroughs in fight against breast cancer

Boston Herald 10/6/2024

Study: Strong immune cells may be the key to living to 100

Atlanta Journal Constitution 4/18/2023

Immune System May Hold Secret to Living to 100

HealthDay 4/6/2023

New Study Finds The Key To Living To 100 And Beyond

iHeart 4/5/2023

Secret To Longevity? Scientists Find Unique Immune Cells In Centenarians That Protect From Illnesses

Medical Daily 4/5/2023

‘Elite’ Immune Systems Could Be Centenarians’ Secret: Study

WebMD 4/5/2023

DNA study reveals one key factor that helps some people live beyond 100

Yahoo News 4/4/2023

This is what you need to live to 100: DNA study

New York Post 4/4/2023

A 'blueprint' for longevity: New study has an answer for why some people live to be over 100

USA Today 4/3/2023

Chemicals in Your Furniture Might Impact Your Metabolism

Technology Networks 8/10/2021

Computational Model Identifies New Candidate Cancer Genes

Drug Target Review 11/18/2019

Foundation focused on causes of breast cancer

The Daily News 5/15/2018

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