Valentina Perissi, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology

PhD, University of California, San Diego
BSc, University of Torino



Valentina Perissi holds a Laurea in Molecular Biology from the University of Torino (Italy) and a PhD in Molecular Pathology from UCSD. After postdoctoral training in Epigenetics, Endocrinology and Metabolism in Dr. Geoff Rosenfeld’s HHMI laboratory at UCSD, she established an independent research group at Boston University. This transition was supported by a K99-R00 career development award from NIDDK and a Peter Paul Career Development Professorship from Boston University.

The overarching theme in the Perissi Lab is dissecting the molecular mechanisms that control metabolic adaptation in response to nutrients availability, cell differentiation and oxidative stress.
Current projects focus on two main areas:
1) Mechanisms regulating mitochondria-nuclear communication and genomic regulation of the mitochondrial stress response
2) Role of non-proteolytic K63 ubiquitination in the regulation of metabolic reprogramming.
Ongoing studies investigate these topics in the context of obesity-associated inflammation/insulin resistance and breast cancer.

Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Coordination of PAR and Ub signaling in mitochondria
04/01/2023 - 03/31/2028 (PI)
NIH/National Institute of General Medical Sciences
1R35GM149339-01

Regulation of mitochondrial homeostasis through retrograde signaling
04/01/2018 - 03/31/2023 (PI)
NIH/National Institute of General Medical Sciences
5R01GM127625-04

Coordinated regulation of breast cancer cell growth and metabolism though inhibition of non-proteolytic K63 ubiquitination
02/01/2017 - 01/31/2021 (PI)
Department of Defense


Ubiquitin-dependent Regulation of Inflammation and Insulin Resistance
04/15/2014 - 03/31/2019 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK100422-05

Expansion of the Diabetes Research Center's Pilot and Feasibility Program
09/14/2012 - 06/30/2016 (Co-Investigator of Sub-Project / SP)
Joslin Diabetes Center NIH NIDDK
5P30DK036836-29

Ubiquitin regulation in PPARgamma-mediated trascriptional regulation
04/01/2012 - 03/31/2014 (Subcontract PI)
Boston Medical Center Corporation NIH NIDDK
5P30DK046200-20

Role of the NCoR Corepressor Complex in the Development of Insulin Resistance
09/25/2010 - 06/30/2013 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R00DK078756-05


Boston Nutrition Obesity Research Center P&F Projects Targeting URM Early Career Scientists
06/01/2021 - 05/31/2024 (PI)
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
3P30DK046200-29S1

Boston Nutrition Obesity Research Center - Administrative Supplement
06/01/2019 - 05/31/2024 (PI)
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
3P30DK046200-27S1

Boston Nutrition Obesity Research Center(Administrative Core
06/01/2018 - 05/31/2024 (Multi-PI)
PI: Valentina Perissi, PhD
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
3P30DK046200-29S1

Boston nutrition Obesity Research Center(CCRC/Epid/Tc)
06/01/2018 - 05/31/2024 (Multi-PI)
PI: Valentina Perissi, PhD
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS

Boston Nutrition Obesity Research Center (Pilot)
06/01/2018 - 05/31/2024 (Multi-PI)
PI: Valentina Perissi, PhD
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS

Boston Nutrition Obesity Research Center - supplement
06/01/2019 - 05/31/2023 (Multi-PI)
PI: Valentina Perissi, PhD
National Institutes of Health/DHHS/NIH
3P30DK046200-29S1


Title


Yr Title Project-Sub Proj Pubs
2023 Coordination of PAR and Ub signaling in mitochondria 1R35GM149339-01
2021 Regulation of mitochondrial homeostasis through retrograde signaling 5R01GM127625-04 2
2021 Boston Nutrition Obesity Research Center 5P30DK046200-29 948
2021 Boston Nutrition Obesity Research Center P&F Projects Targeting URM Early Career Scientists 3P30DK046200-29S1 948
2021 Boston Nutrition Obesity Research Center 3P30DK046200-29S2 948
2020 Regulation of mitochondrial homeostasis through retrograde signaling 5R01GM127625-03 2
2019 Regulation of mitochondrial homeostasis through retrograde signaling 5R01GM127625-02 2
2018 Regulation of mitochondrial homeostasis through retrograde signaling 3R01GM127625-01S1 2
2018 Regulation of mitochondrial homeostasis through retrograde signaling 1R01GM127625-01 2
2018 Ubiquitin-dependent regulation of inflammation and insulin resistance 5R01DK100422-05 6
Showing 10 of 19 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Mitro N, Verdeguer F, Perissi V. Editorial: Epigenetics and metabolism. Front Endocrinol (Lausanne). 2024; 15:1373368. PMID: 38405145; PMCID: PMC10884298; DOI: 10.3389/fendo.2024.1373368;
     
  2. Sepulveda GP, Gushchanskaia ES, Mora-Martin A, Esse R, Nikorich I, Ceballos A, Kwan J, Blum BC, Dholiya P, Emili A, Perissi V, Cardamone MD, Grishok A. DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin. bioRxiv. 2024 Feb 07.View Related Profiles. PMID: 38370658; PMCID: PMC10871221; DOI: 10.1101/2024.02.06.579191;
     
  3. Oliveira AG, Oliveira LD, Cruz MV, Guimarães DSPSF, Lima TI, Santos-Fávero BC, Luchessi AD, Pauletti BA, Leme AP, Bajgelman MC, Afonso J, Regitano LCA, Carvalho HF, Carneiro EM, Kobarg J, Perissi V, Auwerx J, Silveira LR. Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response. J Biol Chem. 2023 Jun; 299(6):104702. PMID: 37059182; PMCID: PMC10203745; DOI: 10.1016/j.jbc.2023.104702;
     
  4. Moore J, Ewoldt J, Venturini G, Pereira AC, Padilha K, Lawton M, Lin W, Goel R, Luptak I, Perissi V, Seidman CE, Seidman J, Chin MT, Chen C, Emili A. Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling. Int J Mol Sci. 2023 Mar 01; 24(5).View Related Profiles. PMID: 36902152; PMCID: PMC10002553; DOI: 10.3390/ijms24054724;
     
  5. English J, Orofino J, Cederquist CT, Paul I, Li H, Auwerx J, Emili A, Belkina A, Cardamone D, Perissi V. GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity. Mol Metab. 2023 Mar; 69:101682.View Related Profiles. PMID: 36731652; PMCID: PMC9922684; DOI: 10.1016/j.molmet.2023.101682;
     
  6. Cardamone MD, Gao Y, Kwan J, Hayashi V, Sheeran M, Xu J, English J, Orofino J, Emili A, Perissi V. Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins. J Cell Biol. 2022 03 07; 221(3).View Related Profiles. PMID: 35157000; PMCID: PMC8932523; DOI: 10.1083/jcb.202101021;
     
  7. Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212.View Related Profiles. PMID: 33417854; PMCID: PMC7831449; DOI: 10.1016/j.molcel.2020.12.028;
     
  8. Chan S, Smith E, Gao Y, Kwan J, Blum BC, Tilston-Lunel AM, Turcinovic I, Varelas X, Cardamone MD, Monti S, Emili A, Perissi V. Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling. Front Cell Dev Biol. 2020; 8:608044.View Related Profiles. PMID: 33490071; PMCID: PMC7817781; DOI: 10.3389/fcell.2020.608044;
     
  9. Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 12 17; 80(6):1104-1122.e9.View Related Profiles. PMID: 33259812; PMCID: PMC7674017; DOI: 10.1016/j.molcel.2020.11.028;
     
  10. English J, Son JM, Cardamone MD, Lee C, Perissi V. Decoding the rosetta stone of mitonuclear communication. Pharmacol Res. 2020 11; 161:105161.View Related Profiles. PMID: 32846213; PMCID: PMC7755734; DOI: 10.1016/j.phrs.2020.105161;
     
Showing 10 of 36 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 36 publications over 23 distinct years, with a maximum of 3 publications in 2018 and 2020 and 2023

YearPublications
19992
20002
20021
20042
20052
20061
20071
20081
20091
20101
20121
20131
20141
20151
20162
20171
20183
20191
20203
20212
20221
20233
20242

2012-2015 Boston University: Peter Paul Professor
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

chromatin remodelling
genomics
inflammation
metabolism
nuclear receptors
transcription
ubiquitin
Mitochondrion
Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
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