Valentina Perissi, PhD
Associate Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of California, San Diego




Valentina Perissi holds a Laurea in Molecular Biology from the University of Torino (Italy) and a PhD in Molecular Pathology from UCSD. After postdoctoral training in Epigenetics, Endocrinology and Metabolism in Dr. Geoff Rosenfeld’s HHMI laboratory at UCSD, she established an independent research group at Boston University. This transition was supported by a K99-R00 career development award from NIDDK and a Peter Paul Career Development Professorship from Boston University.

The overarching theme in the Perissi Lab is dissecting the molecular mechanisms that control metabolic adaptation in response to nutrients availability, cell differentiation and oxidative stress.
Current projects focus on two main areas:
1) Mechanisms regulating mitochondria-nuclear communication and genomic regulation of the mitochondrial stress response
2) Role of non-proteolytic K63 ubiquitination in the regulation of metabolic reprogramming.
Ongoing studies investigate these topics in the context of obesity-associated inflammation/insulin resistance and breast cancer.

Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2012-2015 Boston University: Peter Paul Professor


Regulation of mitochondrial homeostasis through retrograde signaling
04/01/2018 - 03/31/2022 (PI)
NIH/National Institute of General Medical Sciences
5R01GM127625-02

Coordinated regulation of breast cancer cell growth and metabolism though inhibition of non-proteolytic K63 ubiquitination
02/01/2017 - 01/31/2020 (PI)
Department of Defense


Ubiquitin-dependent Regulation of Inflammation and Insulin Resistance
04/15/2014 - 03/31/2019 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK100422-05

Expansion of the Diabetes Research Center's Pilot and Feasibility Program
09/14/2012 - 06/30/2016 (SP Co-PI of Sub-Project / SP)
Joslin Diabetes Center NIH NIDDK
5P30DK036836-29

Ubiquitin regulation in PPARgamma-mediated trascriptional regulation
04/01/2012 - 03/31/2014 (Subcontract PI)
Boston Medical Center Corporation NIH NIDDK
5P30DK046200-20

Role of the NCoR Corepressor Complex in the Development of Insulin Resistance
09/25/2010 - 06/30/2013 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R00DK078756-05



Title


Yr Title Project-Sub Proj Pubs
2020 Regulation of mitochondrial homeostasis through retrograde signaling 5R01GM127625-03 2
2020 Regulation of mitochondrial homeostasis through retrograde signaling 5R01GM127625-03 2
2019 Regulation of mitochondrial homeostasis through retrograde signaling 5R01GM127625-02 2
2018 Regulation of mitochondrial homeostasis through retrograde signaling 1R01GM127625-01 2
2018 Regulation of mitochondrial homeostasis through retrograde signaling 3R01GM127625-01S1 2
2018 Ubiquitin-dependent regulation of inflammation and insulin resistance 5R01DK100422-05 6
2017 Ubiquitin-dependent regulation of inflammation and insulin resistance 5R01DK100422-04 6
2016 Ubiquitin-dependent regulation of inflammation and insulin resistance 5R01DK100422-03 6
2015 Ubiquitin-dependent regulation of inflammation and insulin resistance 5R01DK100422-02 6
2014 Ubiquitin-dependent regulation of inflammation and insulin resistance 1R01DK100422-01 6
Showing 10 of 15 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. English J, Son JM, Cardamone MD, Lee C, Perissi V. Decoding the rosetta stone of mitonuclear communication. Pharmacol Res. 2020 Aug 23; 161:105161.View Related Profiles. PMID: 32846213
     
  2. Jones JEC, Rabhi N, Orofino J, Gamini R, Perissi V, Vernochet C, Farmer SR. The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet. Sci Rep. 2020 02 11; 10(1):2380.View Related Profiles. PMID: 32047213
     
  3. Lima TI, Guimarães DSPSF, Oliveira AG, Araujo H, Sponton CHG, Souza-Pinto NC, Saito Â, Figueira ACM, Palameta S, Bajgelman MC, Calixto A, Pinto S, Mori MA, Orofino J, Perissi V, Mottis A, Auwerx J, Silveira LR. Opposing action of NCoR1 and PGC-1a in mitochondrial redox homeostasis. Free Radic Biol Med. 2019 11 01; 143:203-208. PMID: 31408725
     
  4. Cardamone MD, Orofino J, Labadorf A, Perissi V. Chromatin Immunoprecipitation of Murine Brown Adipose Tissue. J Vis Exp. 2018 11 21; (141).View Related Profiles. PMID: 30531713
     
  5. Vincent AE, Rosa HS, Pabis K, Lawless C, Chen C, Grünewald A, Rygiel KA, Rocha MC, Reeve AK, Falkous G, Perissi V, White K, Davey T, Petrof BJ, Sayer AA, Cooper C, Deehan D, Taylor RW, Turnbull DM, Picard M. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Ann Neurol. 2018 08; 84(2):289-301. PMID: 30014514
     
  6. Cardamone MD, Tanasa B, Cederquist CT, Huang J, Mahdaviani K, Li W, Rosenfeld MG, Liesa M, Perissi V. Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. Mol Cell. 2018 03 01; 69(5):757-772.e7.View Related Profiles. PMID: 29499132
     
  7. Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 2017 Jul; 18(7):1123-1138.View Related Profiles. PMID: 28539390
     
  8. Lentucci C, Belkina AC, Cederquist CT, Chan M, Johnson HE, Prasad S, Lopacinski A, Nikolajczyk BS, Monti S, Snyder-Cappione J, Tanasa B, Cardamone MD, Perissi V. Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development. J Biol Chem. 2017 Feb 17; 292(7):2754-2772.View Related Profiles. PMID: 28039360; DOI: 10.1074/jbc.M116.755132;
     
  9. Cederquist CT, Lentucci C, Martinez-Calejman C, Hayashi V, Orofino J, Guertin D, Fried SK, Lee MJ, Cardamone MD, Perissi V. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Mol Metab. 2017 01; 6(1):125-137.View Related Profiles. PMID: 28123943; DOI: 10.1016/j.molmet.2016.10.007;
     
  10. Huang J, Cardamone MD, Johnson HE, Neault M, Chan M, Floyd ZE, Mallette FA, Perissi V. Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation. J Biol Chem. 2015 Jul 31; 290(31):19044-54.View Related Profiles. PMID: 26070566; PMCID: PMC4521029; DOI: 10.1074/jbc.M115.637660;
     
Showing 10 of 27 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 27 publications over 19 distinct years, with a maximum of 3 publications in 2018

YearPublications
19992
20002
20021
20042
20052
20061
20071
20081
20091
20101
20121
20131
20141
20151
20162
20171
20183
20191
20202
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

chromatin remodelling
genomics
inflammation
metabolism
nuclear receptors
transcription
ubiquitin
Mitochondrion
Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
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