Konstantin Kandror, PhD
Professor
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology

PhD, USSR Academy of Sciences
BS, Moscow State University



Expertise includes: Insulin action; Adipocyte biology; Membrane traffic.

Adipocytes, skeletal myocytes and some neurons express a specific isoform of the glucose transporter protein, Glut4. Under basal conditions this transporter is localized in intracellular membrane vesicles which fuse with the plasma membrane upon insulin administration. Translocation of Glut4 plays a major role in post-prandial glucose clearance and, more generally, in glucose sensing and metabolic homeostasis in the body. For a number of years, my lab has been involved in the dissection of the “Glut4 pathway” in various insulin-sensitive cells.

Another key physiological function of insulin is to inhibit lipolysis and to promote storage of triglycerides in fat tissue. Recently, we have discovered two novel pathways of regulation of lipolysis by insulin. One of these pathways is mediated by the insulin- and nutrient-sensitive mammalian Target of Rapamycin Complex 1, while the other is mediated by transcriptional factor FoxO1. Currently, we are engaged in the dissection of both pathways at the molecular level.

Fat represents an important secretory tissue in the body. Unlike typical endocrine and exocrine cells, adipocytes produce and secret several physiologically important proteins, such as leptin, adiponectin, lipoprotein lipase, etc. and switch the secretory process from one protein to another in response to changing metabolic conditions. We are exploring connections between food intake, obesity and secretion of adipokines in order to understand the central role of fat tissue in the orchestrating the overall response of the organism to changing metabolic conditions.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Professor
Boston University Chobanian & Avedisian School of Medicine
Endocrinology, Diabetes & Nutrition


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Insulin Regulation of Cell Nutrition
03/06/2020 - 02/29/2024 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK052057-23

Regulation of leptin production by mTORC1
01/01/2018 - 06/30/2021 (PI)
American Diabetes Association


Regulation of Lipolysis by mTORC1
02/10/2016 - 01/31/2021 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK107498-04

Insulin Regulation of Cell Nutrition
09/01/2015 - 02/29/2020 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK052057-19

Boston Nutrition Obesity Research Center
07/01/2017 - 05/31/2018 (Key Person / Mentor)
Boston Medical Center Corporation NIH NIDDK
5P30DK046200-25

Reprogramming Fatty Acid handling to improve adipocyte function in human obesity
07/01/2016 - 12/31/2017 (Subcontract PI)
Icahn School of Medicine at Mount Sinai Amer Diabetes Assoc


Cide Proteins and Regulation of Energy Expenditure
09/01/2015 - 08/31/2017 (Subcontract PI)
Ohio University NIH NIDDK
7R01DK101711-03

Reprogramming Fatty Acid handling to improve adipocyte function in human obesity
01/01/2015 - 06/30/2016 (Subcontract PI)
Boston Medical Center Corporation Amer Diabetes Assoc


Insulin Regulation of Cell Nutrition
08/25/2014 - 08/31/2015 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
2R56DK052057-16

Insulin Regulation of Cell Nutrition
06/01/2008 - 08/24/2014 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK052057-15

Showing 10 of 19 results. Show All Results

Metabolism, Endocrinology & Obesity Training Grant
07/01/2014 - 06/30/2024 (Multi-PI)
PI: Konstantin Kandror, PhD
National Institutes of Health/DHHS/NIH
2T32DK007201-37


Title


Yr Title Project-Sub Proj Pubs
2023 Metabolism, Endocrinology, and Obesity Training Grant 5T32DK007201-46
2023 Insulin regulation of cell nutrition 5R01DK052057-23
2022 Metabolism, Endocrinology, and Obesity Training Grant 5T32DK007201-45
2022 Insulin regulation of cell nutrition 5R01DK052057-22
2021 Metabolism, Endocrinology, and Obesity Training Grant 5T32DK007201-44 75
2021 Insulin regulation of cell nutrition 5R01DK052057-21 48
2020 Metabolism, Endocrinology, and Obesity Training Grant 5T32DK007201-43 75
2020 Insulin regulation of cell nutrition 2R01DK052057-20A1 48
2019 Regulation of lipolysis by mTORC1 5R01DK107498-04 4
2019 Metabolism, Endocrinology, and Obesity Training Grant 2T32DK007201-42 75
Showing 10 of 52 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Zaarur N, Meriin AB, Singh M, Goel RK, Zaia J, Kandror KV. Akt may associate with insulin-responsive vesicles via interaction with sortilin. FEBS Lett. 2024 Feb; 598(4):390-399.View Related Profiles. PMID: 38105115
     
  2. Lotfollahzadeh S, Xia C, Amraei R, Hua N, Kandror KV, Farmer SR, Wei W, Costello CE, Chitalia V, Rahimi N. Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity. Mol Metab. 2023 Jul; 73:101744.View Related Profiles. PMID: 37245847; PMCID: PMC10267597; DOI: 10.1016/j.molmet.2023.101744;
     
  3. Meriin AB, Zaarur N, Roy D, Kandror KV. Egr1 plays a major role in the transcriptional response of white adipocytes to insulin and environmental cues. Front Cell Dev Biol. 2022; 10:1003030.View Related Profiles. PMID: 36246998; PMCID: PMC9554007; DOI: 10.3389/fcell.2022.1003030;
     
  4. Meriin AB, Zaarur N, Bogan JS, Kandror KV. Inhibitors of RNA and protein synthesis cause Glut4 translocation and increase glucose uptake in adipocytes. Sci Rep. 2022 Sep 19; 12(1):15640.View Related Profiles. PMID: 36123369; PMCID: PMC9485115; DOI: 10.1038/s41598-022-19534-5;
     
  5. Zaarur N, Desevin K, Mackenzie J, Lord A, Grishok A, Kandror KV. ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans. Mol Metab. 2019 09; 27:75-82.View Related Profiles. PMID: 31311719; PMCID: PMC6717769; DOI: 10.1016/j.molmet.2019.07.001;
     
  6. Pan X, Meriin A, Huang G, Kandror KV. Insulin-responsive amino peptidase follows the Glut4 pathway but is dispensable for the formation and translocation of insulin-responsive vesicles. Mol Biol Cell. 2019 06 01; 30(12):1536-1543.View Related Profiles. PMID: 30943117; PMCID: PMC6724691; DOI: 10.1091/mbc.E18-12-0792;
     
  7. Mohtar O, Ozdemir C, Roy D, Shantaram D, Emili A, Kandror KV. Egr1 mediates the effect of insulin on leptin transcription in adipocytes. J Biol Chem. 2019 04 12; 294(15):5784-5789.View Related Profiles. PMID: 30846562; PMCID: PMC6463691; DOI: 10.1074/jbc.AC119.007855;
     
  8. Zaarur N, Pan X, Kandror KV. Detection of Detergent-sensitive Interactions Between Membrane Proteins. J Vis Exp. 2018 03 07; (133).View Related Profiles. PMID: 29578521; PMCID: PMC5931480; DOI: 10.3791/57179;
     
  9. Boesze-Battaglia K, Walker LP, Dhingra A, Kandror K, Tang HY, Shenker BJ. Internalization of the Active Subunit of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Is Dependent upon Cellugyrin (Synaptogyrin 2), a Host Cell Non-Neuronal Paralog of the Synaptic Vesicle Protein, Synaptogyrin 1. Front Cell Infect Microbiol. 2017; 7:469. PMID: 29184850; PMCID: PMC5694546; DOI: 10.3389/fcimb.2017.00469;
     
  10. Kandror KV. Mammalian target of rapamycin complex 1 and FoxO1 in the transcriptional control of lipolysis and de novo lipogenesis. Curr Opin Endocrinol Diabetes Obes. 2017 Oct; 24(5):326-331. PMID: 28841634
     
Showing 10 of 100 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 100 publications over 36 distinct years, with a maximum of 5 publications in 1994 and 1996 and 2004 and 2009

YearPublications
19822
19831
19843
19883
19892
19904
19912
19923
19931
19945
19953
19965
19971
19984
19994
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20063
20072
20084
20095
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20193
20222
20232


2015 Boston University School of Medicine: Best Collaborator Award
2011 ADA 71st Scientific Sessions: Chair
2007 Endocrine Society: Outstanding Reviewer Recognition Award
1987 USSR: State Prize for the Young Scientists
Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
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617.638.5049
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