Konstantin Kandror, PhD
Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, USSR Academy of Sciences




Expertise includes: Insulin action; Adipocyte biology; Membrane traffic.

Adipocytes, skeletal myocytes and some neurons express a specific isoform of the glucose transporter protein, Glut4. Under basal conditions this transporter is localized in intracellular membrane vesicles which fuse with the plasma membrane upon insulin administration. Translocation of Glut4 plays a major role in post-prandial glucose clearance and, more generally, in glucose sensing and metabolic homeostasis in the body. For a number of years, my lab has been involved in the dissection of the “Glut4 pathway” in various insulin-sensitive cells.

Another key physiological function of insulin is to inhibit lipolysis and to promote storage of triglycerides in fat tissue. Recently, we have discovered two novel pathways of regulation of lipolysis by insulin. One of these pathways is mediated by the insulin- and nutrient-sensitive mammalian Target of Rapamycin Complex 1, while the other is mediated by transcriptional factor FoxO1. Currently, we are engaged in the dissection of both pathways at the molecular level.

Fat represents an important secretory tissue in the body. Unlike typical endocrine and exocrine cells, adipocytes produce and secret several physiologically important proteins, such as leptin, adiponectin, lipoprotein lipase, etc. and switch the secretory process from one protein to another in response to changing metabolic conditions. We are exploring connections between food intake, obesity and secretion of adipokines in order to understand the central role of fat tissue in the orchestrating the overall response of the organism to changing metabolic conditions.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Professor
Boston University School of Medicine
Endocrinology, Diabetes & Nutrition


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences



2015 Boston University School of Medicine: Best Collaborator Award
2011 ADA 71st Scientific Sessions: Chair
2007 Endocrine Society: Outstanding Reviewer Recognition Award
1987 USSR: State Prize for the Young Scientists


Insulin Regulation of Cell Nutrition
03/06/2020 - 02/29/2024 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
2R01DK052057-20A1

Regulation of Lipolysis by mTORC1
02/10/2016 - 01/31/2021 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK107498-04

Regulation of leptin production by mTORC1
01/01/2018 - 12/31/2020 (PI)
American Diabetes Association


Insulin Regulation of Cell Nutrition
09/01/2015 - 02/29/2020 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK052057-19

Reprogramming Fatty Acid handling to improve adipocyte function in human obesity
07/01/2016 - 12/31/2017 (Subcontract PI)
Icahn School of Medicine at Mount Sinai Amer Diabetes Assoc


Cide Proteins and Regulation of Energy Expenditure
09/01/2015 - 08/31/2017 (Subcontract PI)
Ohio University NIH NIDDK
7R01DK101711-03

Reprogramming Fatty Acid handling to improve adipocyte function in human obesity
01/01/2015 - 06/30/2016 (Subcontract PI)
Boston Medical Center Corporation Amer Diabetes Assoc


Insulin Regulation of Cell Nutrition
08/25/2014 - 08/31/2015 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
2R56DK052057-16

Insulin Regulation of Cell Nutrition
06/01/2008 - 08/24/2014 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK052057-15

AMPK and adipose tissue biology in bariatric surgury patients
07/16/2012 - 06/30/2014 (Subcontract PI)
Boston Medical Center Corporation NIH NIDDK
1R24DK094749-01

Showing 10 of 18 results. Show All Results

Metabolism, Endocrinology & Obesity Training Grant
07/01/2014 - 06/30/2020 (PI)
NIH-NIDDK
5T32DK007201-41


Title


Yr Title Project-Sub Proj Pubs
2020 Metabolism, Endocrinology, and Obesity Training Grant 5T32DK007201-43 75
2020 Insulin regulation of cell nutrition 2R01DK052057-20A1 48
2020 Insulin regulation of cell nutrition 2R01DK052057-20A1 48
2019 Regulation of lipolysis by mTORC1 5R01DK107498-04 4
2019 Metabolism, Endocrinology, and Obesity Training Grant 2T32DK007201-42 75
2018 Regulation of lipolysis by mTORC1 5R01DK107498-03 4
2018 Metabolism, Endocrinology and Obesity Training Grant 5T32DK007201-41 75
2018 Insulin regulation of cell nutrition 5R01DK052057-19 48
2017 Regulation of lipolysis by mTORC1 5R01DK107498-02 4
2017 Metabolism, Endocrinology and Obesity Training Grant 5T32DK007201-40 75
Showing 10 of 47 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Zaarur N, Desevin K, Mackenzie J, Lord A, Grishok A, Kandror KV. ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans. Mol Metab. 2019 09; 27:75-82.View Related Profiles. PMID: 31311719
     
  2. Pan X, Meriin A, Huang G, Kandror KV. Insulin-responsive amino peptidase follows the Glut4 pathway but is dispensable for the formation and translocation of insulin-responsive vesicles. Mol Biol Cell. 2019 06 01; 30(12):1536-1543.View Related Profiles. PMID: 30943117
     
  3. Mohtar O, Ozdemir C, Roy D, Shantaram D, Emili A, Kandror KV. Egr1 mediates the effect of insulin on leptin transcription in adipocytes. J Biol Chem. 2019 04 12; 294(15):5784-5789.View Related Profiles. PMID: 30846562
     
  4. Zaarur N, Pan X, Kandror KV. Detection of Detergent-sensitive Interactions Between Membrane Proteins. J Vis Exp. 2018 03 07; (133).View Related Profiles. PMID: 29578521
     
  5. Boesze-Battaglia K, Walker LP, Dhingra A, Kandror K, Tang HY, Shenker BJ. Internalization of the Active Subunit of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Is Dependent upon Cellugyrin (Synaptogyrin 2), a Host Cell Non-Neuronal Paralog of the Synaptic Vesicle Protein, Synaptogyrin 1. Front Cell Infect Microbiol. 2017; 7:469. PMID: 29184850
     
  6. Kandror KV. Mammalian target of rapamycin complex 1 and FoxO1 in the transcriptional control of lipolysis and de novo lipogenesis. Curr Opin Endocrinol Diabetes Obes. 2017 Oct; 24(5):326-331. PMID: 28841634
     
  7. Pan X, Zaarur N, Singh M, Morin P, Kandror KV. Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes. Mol Biol Cell. 2017 Jun 15; 28(12):1667-1675.View Related Profiles. PMID: 28450454
     
  8. Kandror KV. The Role of Sortilin in the “Glut4 Pathway”. Communicative & integrative biology. 2017; 11(1). View Publication
  9. Chakrabarti P, Kandror KV. The role of mTOR in lipid homeostasis and diabetes progression. Curr Opin Endocrinol Diabetes Obes. 2015 Oct; 22(5):340-6.View Related Profiles. PMID: 26241026; DOI: 10.1097/MED.0000000000000187;
     
  10. Singh M, Shin YK, Yang X, Zehr B, Chakrabarti P, Kandror KV. 4E-BPs Control Fat Storage by Regulating the Expression of Egr1 and ATGL. J Biol Chem. 2015 Jul 10; 290(28):17331-8.View Related Profiles. PMID: 25814662; PMCID: PMC4498071; DOI: 10.1074/jbc.M114.631895;
     
Showing 10 of 96 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 96 publications over 34 distinct years, with a maximum of 5 publications in 1994 and 1996 and 2004 and 2009

YearPublications
19822
19831
19843
19883
19892
19904
19912
19923
19931
19945
19953
19965
19971
19984
19994
20004
20013
20023
20032
20045
20052
20063
20072
20084
20095
20102
20114
20121
20132
20141
20152
20174
20181
20193

Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
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