Thor Stein, MD, PhD
Assistant Professor
Boston University School of Medicine
Dept of Pathology & Laboratory Medicine

MD, University of Wisconsin Madison
PhD, University of Wisconsin Madison



Dr. Stein completed his undergraduate and graduate studies at the University of Wisconsin- Madison where he earned his MD and PhD (neuroscience) degrees. He completed residency training in pathology and fellowship training in neuropathology at Massachusetts General Hospital. In 2011 he became Assistant Professor of Pathology at Boston University School of Medicine.

Research Interests:
Dr. Stein’s research interests involve the study of neurodegenerative diseases, including Alzheimer disease and Amyotrophic Lateral Sclerosis (ALS). He studies the role of trauma in the abnormal accumulation of tau and proteins involved in RNA processing. He is an acting neuropathologist involved with the brain banks for the Boston University Alzheimer Disease Center, CTE Center, Framingham Heart Study, as well as the National Veterans Administration ALS brain bank.

CTE Center Role:
Dr. Stein is part of the Neuropathology Core of the SLI-BU CTE Brain Bank, where he conducts neuropathological analysis of brain tissue and helps maintain the SLI-BU CTE Brain Bank.

Awards/Memberships:
Dr. Stein is a recipient of the 2011 American Association of Neuropathologists Moore Award. He is a member of the Society for Neuroscience and the College of American Pathologists.

VA Boston Healthcare System




EPIGENETIC CHANGES IN SYNAPTIC AND INFLAMMATORY GENES INVOLVED IN THE AGE-DEPENDENT DEVELOPMENT OF ALZHEIMER
09/15/2016 - 06/30/2021 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
3RF1AG054156-01S1

ESTABLISHING A BIOREPOSITORY OF AMYOTROPIC LATERAL SCLEROSIS (ALS)
09/28/2015 - 09/27/2020 (PI)
McKing Consulting Corporation HHS/CDC/ATSDR

AGE-ASSOCIATED LIPIDOMIC CHANGES IN ALZHEIMER'S DISEASE
09/30/2017 - 08/31/2019 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
1R56AG057768-01

ESTABLISHING A BIOREPOSITORY OF AMYOTROPIC LATERAL SCLEROSIS (ALS)
09/28/2016 - 09/27/2018 (PI)
McKing Consulting Corporation HHS/CDC/ATSDR

PERSONNEL AGREEMENT FOR RESEARCH SERVICES OF KERRY CORMIER
08/01/2015 - 07/31/2017 (PI)
Department of Veterans Administration, Bedford

ALS BRAIN REPOSITORY
06/01/2013 - 09/22/2016 (PI)
McKing Consulting Corporation HHS CDC




Yr Title Project-Sub Proj Pubs
2019 The neuropathology of mild traumatic brain injury in Alzheimer disease 2I01CX001038-05
2018 The neuropathology of mild traumatic brain injury in Alzheimer's disease 5I01CX001038-04
2017 Age-Associated Lipidomic Changes in Alzheimer's Disease 1R56AG057768-01
2017 The neuropathology of mild traumatic brain injury in Alzheimer's disease 5I01CX001038-03
2016 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive decline 1RF1AG054156-01
2016 The neuropathology of mild traumatic brain injury in Alzheimer's disease 5I01CX001038-02
2016 VA Biorepository Brain Bank 5I01BX002466-03
2015 VA Biorepository Brain Bank 5I01BX002466-02
2014 VA Biorepository Brain Bank 1I01BX002466-01
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Walt GS, Burris HM, Brady CB, Spencer KR, Alvarez VE, Huber BR, Guilderson L, Abdul Rauf N, Collins D, Singh T, Mathias R, Averill JG, Walker SE, Robey I, McKee AC, Kowall NW, Stein TD. Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort. J Neuropathol Exp Neurol. 2018 Dec 01; 77(12):1091-1100.View Related Profiles. PMID: 30299493.
     
  2. Cherry JD, Mez J, Crary JF, Tripodis Y, Alvarez VE, Mahar I, Huber BR, Alosco ML, Nicks R, Abdolmohammadi B, Kiernan PT, Evers L, Svirsky S, Babcock K, Gardner HM, Meng G, Nowinski CJ, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Farrer LA, McKee AC, Stein TD. Variation in TMEM106B in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2018 Nov 04; 6(1):115.View Related Profiles. PMID: 30390709.
     
  3. Morrison FG, Miller MW, Wolf EJ, Logue MW, Maniates H, Kwasnik D, Cherry JD, Svirsky S, Restaino A, Hildebrandt A, Aytan N, Stein TD, Alvarez VE, McKee AC, Huber BR. Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression. Neurosci Lett. 2018 Oct 23; 692:204-209.View Related Profiles. PMID: 30366016.
     
  4. Hsu ET, Gangolli M, Su S, Holleran L, Stein TD, Alvarez VE, McKee AC, Schmidt RE, Brody DL. Astrocytic degeneration in chronic traumatic encephalopathy. Acta Neuropathol. 2018 Dec; 136(6):955-972.View Related Profiles. PMID: 30194648.
     
  5. Adams JW, Alvarez VE, Mez J, Huber BR, Tripodis Y, Xia W, Meng G, Kubilus CA, Cormier K, Kiernan PT, Daneshvar DH, Chua AS, Svirsky S, Nicks R, Abdolmohammadi B, Evers L, Solomon TM, Cherry JD, Aytan N, Mahar I, Devine S, Auerbach S, Alosco ML, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, Au R, McKee AC, Stein TD. Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports. J Neuropathol Exp Neurol. 2018 Sep 01; 77(9):757-768.View Related Profiles. PMID: 30053297.
     
  6. Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Stern RA. Cerebrospinal fluid tau, Aß, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement. 2018 Sep; 14(9):1159-1170.View Related Profiles. PMID: 30049650.
     
  7. Alosco ML, Mez J, Tripodis Y, Kiernan PT, Abdolmohammadi B, Murphy L, Kowall NW, Stein TD, Huber BR, Goldstein LE, Cantu RC, Katz DI, Chaisson CE, Martin B, Solomon TM, McClean MD, Daneshvar DH, Nowinski CJ, Stern RA, McKee AC. Age of first exposure to tackle football and chronic traumatic encephalopathy. Ann Neurol. 2018 May; 83(5):886-901.View Related Profiles. PMID: 29710395.
     
  8. Chen M, Lee HK, Moo L, Hanlon E, Stein T, Xia W. Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients. J Proteomics. 2018 Jun 30; 182:21-33.View Related Profiles. PMID: 29709615.
     
  9. Mufson EJ, He B, Ginsberg SD, Carper BA, Bieler GS, Crawford F, Alvarez VE, Huber BR, Stein TD, McKee AC, Perez SE. Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study. J Neurotrauma. 2018 Jun 01; 35(11):1260-1271.View Related Profiles. PMID: 29338612.
     
  10. Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE. Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model. Brain. 2018 Feb 01; 141(2):422-458.View Related Profiles. PMID: 29360998; DOI: 10.1093/brain/awx350;.
     
Showing 10 of 56 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 56 publications over 15 distinct years, with a maximum of 13 publications in 2018

YearPublications
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201813
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Recent (within 3 months)

Why Some People Develop More Severe CTE Symptoms than Others

Association of American Universities 11/21/2018

Scientists zero in on genetic risk factor for Alzheimer's-like brain disease CTE

WBUR 11/5/2018

Specific Gene Variant Linked To Severe Symptoms Of CTE

UPI 11/5/2018

BU researchers make first link from severe CTE to genes

The Boston Globe 11/4/2018

Why Some People’s CTE Symptoms Are More Severe Than Others

BU Today 11/3/2018
Older

Parkinson’s Symptoms Associated with Contact Sports

Genetic Engineering & Biotechnology News 7/26/2018

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