Thor Stein, MD, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

MD, University of Wisconsin Madison
PhD, University of Wisconsin Madison
BS, University of Wisconsin Madison



Dr. Stein completed his undergraduate and graduate studies at the University of Wisconsin- Madison where he earned his MD and PhD (neuroscience) degrees. He completed residency training in pathology and fellowship training in neuropathology at Massachusetts General Hospital. In 2011 he became Assistant Professor of Pathology at Chobanian and Avedisian School of Medicine.

Research Interests:
Dr. Stein’s research interests involve the study of neurodegenerative diseases, including Alzheimer disease and Amyotrophic Lateral Sclerosis (ALS). He studies the role of trauma in the abnormal accumulation of tau and proteins involved in RNA processing. He is an acting neuropathologist involved with the brain banks for the Boston University Alzheimer Disease Center, CTE Center, Framingham Heart Study, as well as the National Veterans Administration ALS brain bank.

CTE Center Role:
Dr. Stein is part of the Neuropathology Core of the SLI-BU CTE Brain Bank, where he conducts neuropathological analysis of brain tissue and helps maintain the SLI-BU CTE Brain Bank.

Awards/Memberships:
Dr. Stein is a recipient of the 2011 American Association of Neuropathologists Moore Award. He is a member of the Society for Neuroscience and the College of American Pathologists.

Investigator
Framingham Heart Study


VA Boston Healthcare System


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Cerebrovascular Remodeling and Neurodegenerative Changes in Alzheimer's Disease
02/01/2022 - 01/31/2027 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
5R01AG075876-02

Boston University Alzheimer's Disease Research Center
08/15/2021 - 06/30/2026 (Key Person)
PI: Ann C. McKee, MD
NIH/National Institute on Aging
5P30AG072978-03

Identification and characterization of the CD31-ApoE-mCRP pathway for Alzheimer's disease in humans.
12/15/2022 - 11/30/2025 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
1RF1AG075832-01A1

Data Call for ALS Biorepository Proposal
09/28/2020 - 09/27/2025 (Subcontract PI)
McKing Consulting Corporation HHS CDC


Blood Biomarker Development and Validation in Chronic Traumatic Encephalopathy and Alzheimer's Disease and Alzheimer's Disease Related Dementias
06/01/2023 - 05/31/2025 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute of Neurological Disorders & Stroke
1RF1NS132290-01

Age-Associated Lipidomic Changes in Alzheimer's Disease
02/01/2019 - 06/30/2024 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
1RF1AG057768-01A1

Personnel Agreement for Research Services of Camille Esnault
09/30/2021 - 09/29/2022 (PI)
Department of Veterans Administration, Bedford


Personnel Agreement for Research Services of Lucas Fishbein
09/30/2021 - 09/29/2022 (PI)
Department of Veterans Administration, Bedford


Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 08/31/2021 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
3RF1AG054156-01S1

Establishing a Biorepository of Amyotropic Lateral Sclerosis (ALS)
09/28/2016 - 09/27/2020 (Subcontract PI)
McKing Consulting Corporation HHS CDC ATSDR


Showing 10 of 14 results. Show All Results


Title
Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
(PI)


Yr Title Project-Sub Proj Pubs
2024 Genetic and environmental modifiers of pathology in amyotrophic lateral sclerosis 5I01BX005161-02
2023 Blood Biomarker Development and Validation in Chronic Traumatic Encephalopathy and Alzheimer's Disease and Alzheimer's Disease Related Dementias 1RF1NS132290-01
2023 Identification and characterization of the CD31-ApoE-mCRP pathway for Alzheimer's disease in humans. 1RF1AG075832-01A1
2023 Cerebrovascular Remodeling and Neurodegenerative Changes in Alzheimer's Disease 5R01AG075876-02
2023 Role of classical complement pathway underling glial phenotypes and multiple pathologies in Alzheimer's disease and cerebrovascular disease 5U19AG068753-04-8065
2023 Brain Bank Core 5U54NS115266-05-6541
2023 TBI-related polyproteinopathy and the role of multiple neurodegenerations in cognitive decline and parkinsonism 5U54NS115266-05-6544
2023 The neuropathology of mild traumatic brain injury in Alzheimer's disease 2I01BX005933-09
2022 Cerebrovascular Remodeling and Neurodegenerative Changes in Alzheimer's Disease 1R01AG075876-01
2022 Role of classical complement pathway underling glial phenotypes and multiple pathologies in Alzheimer's disease and cerebrovascular disease 5U19AG068753-03-8041
Showing 10 of 33 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Stern RA, Trujillo-Rodriguez D, Tripodis Y, Pulukuri SV, Alosco ML, Adler CH, Balcer LJ, Bernick C, Baucom Z, Marek KL, McClean MD, Johnson KA, McKee AC, Stein TD, Mez J, Palmisano JN, Cummings JL, Shenton ME, Reiman EM. Amyloid PET across the cognitive spectrum in former professional and college American football players: findings from the DIAGNOSE CTE Research Project. Alzheimers Res Ther. 2023 Oct 05; 15(1):166.View Related Profiles. PMID: 37798671; PMCID: PMC10552261; DOI: 10.1186/s13195-023-01315-5;
     
  2. Heo JY, Park AH, Lee MJ, Ryu MJ, Kim YK, Jang YS, Kim SJ, Shin SY, Son HJ, Stein TD, Huh YH, Chung SK, Choi SY, Kim JM, Hwang O, Shong M, Hyeon SJ, Lee J, Ryu H, Kim D, Kweon GR. Correction: Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism. Mol Psychiatry. 2023 Oct 02.View Related Profiles. PMID: 37783789
     
  3. McKee AC, Mez J, Abdolmohammadi B, Butler M, Huber BR, Uretsky M, Babcock K, Cherry JD, Alvarez VE, Martin B, Tripodis Y, Palmisano JN, Cormier KA, Kubilus CA, Nicks R, Kirsch D, Mahar I, McHale L, Nowinski C, Cantu RC, Stern RA, Daneshvar D, Goldstein LE, Katz DI, Kowall NW, Dwyer B, Stein TD, Alosco ML. Neuropathologic and Clinical Findings in Young Contact Sport Athletes Exposed to Repetitive Head Impacts. JAMA Neurol. 2023 Oct 01; 80(10):1037-1050.View Related Profiles. PMID: 37639244; PMCID: PMC10463175; DOI: 10.1001/jamaneurol.2023.2907;
     
  4. Bihn JR, Cioffi G, Waite KA, Kruchko C, Neff C, Price M, Ostrom QT, Swinnerton KN, Elbers DC, Mooney MA, Rachlin J, Stein TD, Brophy MT, Do NV, Ferguson RE, Priemer DS, Perl DP, Hickman RA, Nabors B, Rusiecki J, Barnholtz-Sloan JS, Fillmore NR. Brain Tumors in United States Military Veterans. Neuro Oncol. 2023 Sep 22.View Related Profiles. PMID: 37738677
     
  5. O'Neill NK, Stein TD, Hu J, Rehman H, Campbell JD, Yajima M, Zhang X, Farrer LA. Bulk brain tissue cell-type deconvolution with bias correction for single-nuclei RNA sequencing data using DeTREM. BMC Bioinformatics. 2023 Sep 19; 24(1):349.View Related Profiles. PMID: 37726653; PMCID: PMC10507917; DOI: 10.1186/s12859-023-05476-w;
     
  6. Blusztajn JK, Aytan N, Rajendiran T, Mellott TJ, Soni T, Burant CF, Serrano GE, Beach TG, Lin H, Stein TD. Cerebral Gray and White Matter Monogalactosyl Diglyceride Levels Rise with the Progression of Alzheimer's Disease. J Alzheimers Dis. 2023 Sep 14.View Related Profiles. PMID: 37718815; DOI: 10.3233/JAD-230543;
     
  7. Heo JY, Park AH, Lee MJ, Ryu MJ, Kim YK, Jang YS, Kim SJ, Shin SY, Son HJ, Stein TD, Huh YH, Chung SK, Choi SY, Kim JM, Hwang O, Shong M, Hyeon SJ, Lee J, Ryu H, Kim D, Kweon GR. Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism. Mol Psychiatry. 2023 Aug 30.View Related Profiles. PMID: 37648779
     
  8. Liu X, Halvorsen S, Blanke N, Downs M, Stein TD, Bigio IJ, Zaia J, Zhang Y. Progressive Mechanical and Structural Changes in Anterior Cerebral Arteries with Alzheimer's Disease. Res Sq. 2023 Aug 29.View Related Profiles. PMID: 37693508; PMCID: PMC10491325; DOI: 10.21203/rs.3.rs-3283587/v1;
     
  9. Bruce HJ, Tripodis Y, McClean M, Korell M, Tanner CM, Contreras B, Gottesman J, Kirsch L, Karim Y, Martin B, Palmisano J, Abdolmohammadi B, Shih LC, Stein TD, Stern RA, Adler CH, Mez J, Nowinski C, McKee AC, Alosco ML. American Football Play and Parkinson Disease Among Men. JAMA Netw Open. 2023 Aug 01; 6(8):e2328644.View Related Profiles. PMID: 37566412; PMCID: PMC10422187; DOI: 10.1001/jamanetworkopen.2023.28644;
     
  10. Rosen G, Kirsch D, Horowitz S, Cherry JD, Nicks R, Kelley H, Uretsky M, Dell'Aquila K, Mathias R, Cormier KA, Kubilus CA, Mez J, Tripodis Y, Stein TD, Alvarez VE, Alosco ML, McKee AC, Huber BR. Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2023 Jul 25; 11(1):123.View Related Profiles. PMID: 37491342; PMCID: PMC10369801; DOI: 10.1186/s40478-023-01612-y;
     
Showing 10 of 148 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 148 publications over 20 distinct years, with a maximum of 22 publications in 2021

YearPublications
20001
20023
20031
20042
20051
20081
20101
20114
20123
20133
20143
20159
20166
20175
201815
20199
202019
202122
202219
202321


Playing tackle football at an early age increases risk for brain decline later

News Medical 3/20/2023

Active disease process in early CTE differs substantially from late-stage disease

News Medical 3/13/2023

Flag football grows in popularity due to head injury concerns

CBS News 3/7/2023

New BU Study Finds Tackle Football at Young Age Raises Risk for Brain Decline Later

The Brink 3/6/2023

They Made History at Alabama. But Football Stardom Had a Price.

The New York Times 8/7/2022

Medical Campus Promotes 13 Faculty to Associate Professor

BU Today 7/30/2021

How CTE contributed to the death of a beloved Bolivar attorney, star athlete

The Springfielf News-Leader 3/25/2021

Troubling Sleep Disorder in Athletes a Sign of CTE?

Medscape 9/30/2020

Boston University research shows rare sleep disorder impacts contact sport athletes

WCVB-TV 9/17/2020

CTE, Contact Sports Play Linked to REM Sleep Behavior Disorder

BU Today 9/16/2020

Boston University researchers discover link between CTE and severe sleep disorder

WHDH-TV 9/16/2019

Tau Pathology Present Decades After a Single Brain Injury

The Scientist 9/9/2019

Study: Playing Contact Sports Significantly Increases Risk Of Lewy Body Disease, Parkinson’s

StudyFinds 4/15/2019

Why Some People Develop More Severe CTE Symptoms than Others

Association of American Universities 11/21/2018

Scientists zero in on genetic risk factor for Alzheimer's-like brain disease CTE

WBUR 11/5/2018

Specific Gene Variant Linked To Severe Symptoms Of CTE

UPI 11/5/2018

BU researchers make first link from severe CTE to genes

The Boston Globe 11/4/2018

Why Some People’s CTE Symptoms Are More Severe Than Others

BU Today 11/3/2018

Parkinson’s Symptoms Associated with Contact Sports

Genetic Engineering & Biotechnology News 7/26/2018
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