Cerebrovascular Remodeling and Neurodegenerative Changes in Alzheimer's Disease
02/01/2022 - 01/31/2027 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
5R01AG075876-03

Boston University Alzheimer's Disease Research Center
08/15/2021 - 06/30/2026 (Key Person)
PI: Ann C. McKee, MD
NIH/National Institute on Aging
5P30AG072978-03

Identification and characterization of the CD31-ApoE-mCRP pathway for Alzheimer's disease in humans.
12/15/2022 - 11/30/2025 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
1RF1AG075832-01A1

Data Call for ALS Biorepository Proposal
09/28/2020 - 09/27/2025 (Subcontract PI)
McKing Consulting Corporation HHS CDC


Blood Biomarker Development and Validation in Chronic Traumatic Encephalopathy and Alzheimer's Disease and Alzheimer's Disease Related Dementias
06/01/2023 - 05/31/2025 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute of Neurological Disorders & Stroke
1RF1NS132290-01

Age-Associated Lipidomic Changes in Alzheimer's Disease
02/01/2019 - 08/31/2024 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
1RF1AG057768-01A1

Personnel Agreement for Research Services of Camille Esnault
09/30/2021 - 09/29/2022 (PI)
Department of Veterans Administration, Bedford


Personnel Agreement for Research Services of Lucas Fishbein
09/30/2021 - 09/29/2022 (PI)
Department of Veterans Administration, Bedford


Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 08/31/2021 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
3RF1AG054156-01S1

Establishing a Biorepository of Amyotropic Lateral Sclerosis (ALS)
09/28/2016 - 09/27/2020 (Subcontract PI)
McKing Consulting Corporation HHS CDC ATSDR


Showing 10 of 14 results. Show All Results

1. Rosen GA, Kirsch D, Nicks R, Kelley H, Mathias R, Cormier KA, Kubilus CA, Dec B, Stein TD, Alvarez VE, Alosco ML, McKee AC, Huber BR. SHARD: an improved method for staining and visualizing multiplex immunofluorescence in optically cleared postmortem human brain tissue. Front Neurosci. 2024; 18:1474617.View Related Profiles.

   McKee, Ann
   Rosen, Grace
   Alosco, Michael
   Stein, Thor
   Alvarez, Victor
   

   PMID: 39445075; PMCID: PMC11496292; DOI: 10.3389/fnins.2024.1474617;
2. Giong HK, Hyeon SJ, Lee JG, Cho HJ, Park U, Stein TD, Lee J, Yu K, Ryu H, Lee JS. Tau accumulation is cleared by the induced expression of VCP via autophagy. Acta Neuropathol. 2024 Sep 24; 148(1):46.View Related Profiles.

   Ryu, Hoon
   Lee, Junghee
   Stein, Thor
   

   PMID: 39316141; PMCID: PMC11422276; DOI: 10.1007/s00401-024-02804-z;
3. Zhang Z, Lin W, Gan Q, Lei M, Gong B, Zhang C, Henrique JS, Han J, Tian H, Tao Q, Potempa LA, Stein TD, Emili A, Qiu WQ. The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP. Angiogenesis. 2024 Sep 14.View Related Profiles.

   Henrique, Jessica
   Tao, Qiushan
   Stein, Thor
   Lin, Weiwei
   

   PMID: 39276310; DOI: 10.1007/s10456-024-09946-4;
4. O'Neill N, Stein TD, Olayinka OA, Empawi JA, Hu J, Tong T, Zhang X, Farrer LA. Cognitive resilience to Alzheimer's disease characterized by cell-type abundance. Alzheimers Dement. 2024 Oct; 20(10):6910-6921.View Related Profiles.

   Farrer, Lindsay
   Stein, Thor
   

   PMID: 39262221
5. Adams JW, Kirsch D, Calderazzo SM, Tuz-Zahra F, Tripodis Y, Mez J, Alosco ML, Alvarez VE, Huber BR, Kubilus C, Cormier KA, Nicks R, Uretsky M, Nair E, Kuzyk E, Aytan N, Cherry JD, Crary JF, Daneshvar DH, Nowinski CJ, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, McKee AC, Stein TD. Substantia Nigra Pathology, Contact Sports Play, and Parkinsonism in Chronic Traumatic Encephalopathy. JAMA Neurol. 2024 Sep 01; 81(9):916-924.View Related Profiles.

   McKee, Ann
   Huber, Bertrand
   Dwyer, Brigid
   Nowinski, Christopher
   Daneshvar, Daniel
   Katz, Douglas
   Mez, Jesse
   Cherry, Jonathan
   Goldstein, Lee
   Alosco, Michael
   Aytan, Nurgul
   Stern, Robert
   Stein, Thor
   Alvarez, Victor
   Tripodis, Yorghos
   

   PMID: 39008284; PMCID: PMC11250391; DOI: 10.1001/jamaneurol.2024.2166;
6. Sampani K, Ness S, Tuz-Zahra F, Aytan N, Spurlock EE, Alluri S, Chen X, Siegel NH, Alosco ML, Xia W, Tripodis Y, Stein TD, Subramanian ML. Neurodegenerative biomarkers in different chambers of the eye relative to plasma: an agreement validation study. Alzheimers Res Ther. 2024 Aug 26; 16(1):192.View Related Profiles.

   Subramanian, Manju
   Alosco, Michael
   Siegel, Nicole
   Aytan, Nurgul
   Stein, Thor
   Tripodis, Yorghos
   

   PMID: 39187891; PMCID: PMC11346268; DOI: 10.1186/s13195-024-01556-y;
7. Yousefian-Jazi A, Kim S, Choi SH, Chu J, Nguyen PT, Park U, Lim K, Hwang H, Lee K, Kim Y, Hyeon SJ, Rhim H, Ryu HL, Lim G, Stein TD, Ryu H, Lee J. Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice. bioRxiv. 2024 Jul 17.View Related Profiles.

   Ryu, Hoon
   Lee, Junghee
   Stein, Thor
   

   PMID: 39071309; PMCID: PMC11275751; DOI: 10.1101/2024.07.15.603186;
8. Sahelijo N, Rajagopalan P, Qian L, Rahman R, Priyadarshi D, Goldstein D, Thomopoulos SI, Bennett DA, Farrer LA, Stein TD, Shen L, Huang H, Nho K, Andrew SJ, Davatzikos C, Thompson PM, Tcw J, Jun GR. Brain Cell-based Genetic Subtyping and Drug Repositioning for Alzheimer Disease. medRxiv. 2024 Jun 21.View Related Profiles.

   Jun, Gyungah
   TCW, Julia
   Farrer, Lindsay
   Stein, Thor
   

   PMID: 38947056; PMCID: PMC11213108; DOI: 10.1101/2024.06.21.24309255;
9. Culhane JE, Jackson CE, Tripodis Y, Nowinski CJ, Dams-O'Connor K, Pettway E, Uretsky M, Abdolmohammadi B, Nair E, Martin B, Palmisano J, Katz DI, Dwyer B, Daneshvar DH, Goldstein LE, Kowall NW, Cantu RC, Stern RA, Huber BR, Crary JF, Mez J, Stein TD, McKee AC, Alosco ML. Lack of Association of Informant-Reported Traumatic Brain Injury and Chronic Traumatic Encephalopathy. J Neurotrauma. 2024 Jun; 41(11-12):1399-1408.View Related Profiles.

   McKee, Ann
   Huber, Bertrand
   Dwyer, Brigid
   Nowinski, Christopher
   Daneshvar, Daniel
   Katz, Douglas
   Mez, Jesse
   Goldstein, Lee
   Alosco, Michael
   Kowall, Neil
   Stern, Robert
   Stein, Thor
   Tripodis, Yorghos
   

   PMID: 38445389; PMCID: PMC11339554; DOI: 10.1089/neu.2023.0391;
10. Wang Y, Huang J, Ang TFA, Zhu Y, Tao Q, Mez J, Alosco M, Denis GV, Belkina A, Gurnani A, Ross M, Gong B, Han J, Lunetta KL, Stein TD, Au R, Farrer LA, Zhang X, Qiu WQ. The association between circulating CD34+CD133+ endothelial progenitor cells and reduced risk of Alzheimer's disease in the Framingham Heart Study. Explor Med. 2024; 5(2):193-214.View Related Profiles.

    Belkina, Anna
    Gurnani, Ashita
    Denis, Gerald
    Mez, Jesse
    Lunetta, Kathryn
    Farrer, Lindsay
    Alosco, Michael
    Tao, Qiushan
    Au, Rhoda
    Stein, Thor
    Ang, Ting Fang Alvin
    

    PMID: 38854406; PMCID: PMC11160969; DOI: 10.37349/emed.2024.00216;

Showing 10 of 171 results. Show More

“It Will Make CTE a Treatable Disease”: The Race for a Diagnosis in Life

10 Things BU CTE Center Research Has Taught Us about the Brain Dangers of Contact Sports and Military Service

Recent deaths of young football players rekindle questions about safety of game

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Head Injury and Parkinsonism—It’s the Tangles, Not the Lewy Bodies

Study probes contact sports, CTE, parkinsonism links

Boston University CTE study finds link between contact sports, CTE, Parkinson's disease

Could Contact Sports Raise Risks for a Parkinson's-like Disorder?

Parkinsonism in Athletes Linked With Chronic Traumatic Encephalopathy Pathology

Study reveals link between contact sports and parkinsons-like symptoms in CTE patients

New hit: Contact sport, CTE link to Parkinson's-style disease

What looks like Parkinson’s may not be in CTE patients

Pioneers Identify Potential New Subtype of CTE

Longer football careers linked to reduced white matter brain integrity, study finds

Playing tackle football at an early age increases risk for brain decline later

Active disease process in early CTE differs substantially from late-stage disease

Flag football grows in popularity due to head injury concerns

New BU Study Finds Tackle Football at Young Age Raises Risk for Brain Decline Later

They Made History at Alabama. But Football Stardom Had a Price.

Medical Campus Promotes 13 Faculty to Associate Professor

How CTE contributed to the death of a beloved Bolivar attorney, star athlete

Troubling Sleep Disorder in Athletes a Sign of CTE?

Boston University research shows rare sleep disorder impacts contact sport athletes

CTE, Contact Sports Play Linked to REM Sleep Behavior Disorder

Boston University researchers discover link between CTE and severe sleep disorder

Tau Pathology Present Decades After a Single Brain Injury

Study: Playing Contact Sports Significantly Increases Risk Of Lewy Body Disease, Parkinson’s

Why Some People Develop More Severe CTE Symptoms than Others

Scientists zero in on genetic risk factor for Alzheimer's-like brain disease CTE

Specific Gene Variant Linked To Severe Symptoms Of CTE

BU researchers make first link from severe CTE to genes

Why Some People’s CTE Symptoms Are More Severe Than Others

Parkinson’s Symptoms Associated with Contact Sports