Thor Stein, MD, PhD
Associate Professor
Boston University School of Medicine
Pathology & Laboratory Medicine

MD, University of Wisconsin Madison
PhD, University of Wisconsin Madison




Dr. Stein completed his undergraduate and graduate studies at the University of Wisconsin- Madison where he earned his MD and PhD (neuroscience) degrees. He completed residency training in pathology and fellowship training in neuropathology at Massachusetts General Hospital. In 2011 he became Assistant Professor of Pathology at Boston University School of Medicine.

Research Interests:
Dr. Stein’s research interests involve the study of neurodegenerative diseases, including Alzheimer disease and Amyotrophic Lateral Sclerosis (ALS). He studies the role of trauma in the abnormal accumulation of tau and proteins involved in RNA processing. He is an acting neuropathologist involved with the brain banks for the Boston University Alzheimer Disease Center, CTE Center, Framingham Heart Study, as well as the National Veterans Administration ALS brain bank.

CTE Center Role:
Dr. Stein is part of the Neuropathology Core of the SLI-BU CTE Brain Bank, where he conducts neuropathological analysis of brain tissue and helps maintain the SLI-BU CTE Brain Bank.

Awards/Memberships:
Dr. Stein is a recipient of the 2011 American Association of Neuropathologists Moore Award. He is a member of the Society for Neuroscience and the College of American Pathologists.

Investigator
Framingham Heart Study


VA Boston Healthcare System


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Cerebrovascular Remodeling and Neurodegenerative Changes in Alzheimer's Disease
02/01/2022 - 01/31/2027 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
1R01AG075876-01

Data Call for ALS Biorepository Proposal
09/28/2020 - 09/27/2025 (Subcontract PI)
McKing Consulting Corporation HHS CDC


Age-Associated Lipidomic Changes in Alzheimer's Disease
02/01/2019 - 01/31/2024 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
3RF1AG057768-01A1S1

Personnel Agreement for Research Services of Camille Esnault
09/30/2021 - 09/29/2022 (PI)
Department of Veterans Administration, Bedford


Personnel Agreement for Research Services of Lucas Fishbein
09/30/2021 - 09/29/2022 (PI)
Department of Veterans Administration, Bedford


Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 08/31/2021 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
3RF1AG054156-01S1

Establishing a Biorepository of Amyotropic Lateral Sclerosis (ALS)
09/28/2016 - 09/27/2020 (Subcontract PI)
McKing Consulting Corporation HHS CDC ATSDR


Establishing a Biorepository of Amyotropic Lateral Sclerosis (ALS)
09/28/2015 - 09/27/2020 (Subcontract PI)
McKing Consulting Corporation HHS CDC ATSDR


Age-Associated Lipidomic Changes in Alzheimer's Disease
09/30/2017 - 01/31/2019 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
1R56AG057768-01

Personnel agreement for research services of Kerry Cormier
08/01/2015 - 07/31/2017 (PI)
Department of Veterans Administration, Bedford


Showing 10 of 11 results. Show All Results


Title
Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer


Yr Title Project-Sub Proj Pubs
2021 Role of classical complement pathway underling glial phenotypes and multiple pathologies in Alzheimer's disease and cerebrovascular disease 5U19AG068753-02-8041
2021 TBI-related polyproteinopathy and the role of multiple neurodegenerations in cognitive decline and parkinsonism 5U54NS115266-03-6602
2021 Age-Associated Lipidomic Changes in Alzheimer's Disease 3RF1AG057768-01A1S1 4
2021 The neuropathology of mild traumatic brain injury in Alzheimer disease 5I01CX001038-07 42
2020 Role of classical complement pathway underling glial phenotypes and multiple pathologies in Alzheimer's disease and cerebrovascular disease 1U19AG068753-01-8041
2020 TBI-related polyproteinopathy and the role of multiple neurodegenerations in cognitive decline and parkinsonism 5U54NS115266-02-6602
2020 The neuropathology of mild traumatic brain injury in Alzheimer disease 5I01CX001038-06 42
2019 Age-Associated Lipidomic Changes in Alzheimer's Disease 1RF1AG057768-01A1 4
2019 The neuropathology of mild traumatic brain injury in Alzheimer disease 2I01CX001038-05 42
2019 TBI-related polyproteinopathy and the role of multiple neurodegenerations in cognitive decline and parkinsonism 1U54NS115266-01-6602
Showing 10 of 21 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Frank B, Ally M, Tripodis Y, Puzo C, Labriolo C, Hurley L, Martin B, Palmisano J, Chan L, Steinberg E, Turk K, Budson A, OÂ'Connor M, Au R, Qiu WQ, Goldstein L, Kukull W, Kowall N, Killiany R, Stern R, Stein T, McKee A, Mez J, Alosco M. Trajectories of Cognitive Decline in Brain Donors With Autopsy-Confirmed Alzheimer Disease and Cerebrovascular Disease. Neurology. 2022 Apr 20.View Related Profiles. PMID: 35444054; DOI: 10.1212/WNL.0000000000200304;
     
  2. Babcock KJ, Abdolmohammadi B, Kiernan PT, Mahar I, Cherry JD, Alvarez VE, Goldstein LE, Stein TD, McKee AC, Huber BR. Interface astrogliosis in contact sport head impacts and military blast exposure. Acta Neuropathol Commun. 2022 Apr 13; 10(1):52.View Related Profiles. PMID: 35418116; PMCID: PMC9009003; DOI: 10.1186/s40478-022-01358-z;
     
  3. Glass JD, Hammers JL, Omalu BL, Bieniek KF, Crary JF, Dickson DW, Stein TD, Mez J, Alosco ME, McKee AC. Erratum to Letters to the Editor regarding: The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol 2021;80(3):210-9. J Neuropathol Exp Neurol. 2022 Feb 24; 81(3):249.View Related Profiles. PMID: 35098301
     
  4. Turk KW, Geada A, Alvarez VE, Xia W, Cherry JD, Nicks R, Meng G, Daley S, Tripodis Y, Huber BR, Budson AE, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Alosco ML, Mez J, McKee AC, Stein TD. A comparison between tau and amyloid-ß cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease. Alzheimers Res Ther. 2022 02 09; 14(1):28.View Related Profiles. PMID: 35139894; PMCID: PMC8830027; DOI: 10.1186/s13195-022-00976-y;
     
  5. Panitch R, Hu J, Xia W, Bennett DA, Stein TD, Farrer LA, Jun GR. Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease. Alzheimers Res Ther. 2022 02 09; 14(1):30.View Related Profiles. PMID: 35139885; PMCID: PMC8830081; DOI: 10.1186/s13195-022-00975-z;
     
  6. Jun GR, You Y, Zhu C, Meng G, Chung J, Panitch R, Hu J, Xia W, Bennett DA, Foroud TM, Wang LS, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Au R, Lunetta KL, Ikezu T, Stein TD, Farrer LA. Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ?2 for Alzheimer's disease. Alzheimers Dement. 2022 Feb 09.View Related Profiles. PMID: 35142023
     
  7. Alosco ML, Mian AZ, Buch K, Farris CW, Uretsky M, Tripodis Y, Baucom Z, Martin B, Palmisano J, Puzo C, Ang TFA, Joshi P, Goldstein LE, Au R, Katz DI, Dwyer B, Daneshvar DH, Nowinski C, Cantu RC, Kowall NW, Huber BR, Alvarez VE, Stern RA, Stein TD, Killiany RJ, McKee AC, Mez J. Structural MRI profiles and tau correlates of atrophy in autopsy-confirmed CTE. Alzheimers Res Ther. 2021 12 07; 13(1):193.View Related Profiles. PMID: 34876229; PMCID: PMC8653514; DOI: 10.1186/s13195-021-00928-y;
     
  8. Stathas S, Alvarez VE, Xia W, Nicks R, Meng G, Daley S, Pothast M, Shah A, Kelley H, Esnault C, McCormack R, Dixon E, Fishbein L, Cherry JD, Huber BR, Tripodis Y, Alosco ML, Mez J, McKee AC, Stein TD. Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease. Alzheimers Dement. 2021 Dec 02.View Related Profiles. PMID: 34854540; DOI: 10.1002/alz.12502;
     
  9. Frank B, Ally M, Brekke B, Zetterberg H, Blennow K, Sugarman MA, Ashton NJ, Karikari TK, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Simkina I, Turk KW, Budson AE, O'Connor MK, Au R, Goldstein LE, Jun GR, Kowall NW, Stein TD, McKee AC, Killiany R, Qiu WQ, Stern RA, Mez J, Alosco ML. Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau. Alzheimers Dement. 2021 Dec 02.View Related Profiles. PMID: 34854549; DOI: 10.1002/alz.12508;
     
  10. Daneshvar DH, Mez J, Alosco ML, Baucom ZH, Mahar I, Baugh CM, Valle JP, Weuve J, Paganoni S, Cantu RC, Zafonte RD, Stern RA, Stein TD, Tripodis Y, Nowinski CJ, McKee AC. Incidence of and Mortality From Amyotrophic Lateral Sclerosis in National Football League Athletes. JAMA Netw Open. 2021 12 01; 4(12):e2138801.View Related Profiles. PMID: 34910152; PMCID: PMC8674746; DOI: 10.1001/jamanetworkopen.2021.38801;
     
Showing 10 of 114 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 114 publications over 19 distinct years, with a maximum of 22 publications in 2021

YearPublications
20001
20023
20031
20042
20051
20081
20101
20114
20123
20133
20143
20159
20166
20175
201815
20199
202019
202122
20226


Medical Campus Promotes 13 Faculty to Associate Professor

BU Today 7/30/2021

How CTE contributed to the death of a beloved Bolivar attorney, star athlete

The Springfielf News-Leader 3/25/2021

Troubling Sleep Disorder in Athletes a Sign of CTE?

Medscape 9/30/2020

Boston University research shows rare sleep disorder impacts contact sport athletes

WCVB-TV 9/17/2020

CTE, Contact Sports Play Linked to REM Sleep Behavior Disorder

BU Today 9/16/2020

Boston University researchers discover link between CTE and severe sleep disorder

WHDH-TV 9/16/2019

Tau Pathology Present Decades After a Single Brain Injury

The Scientist 9/9/2019

Study: Playing Contact Sports Significantly Increases Risk Of Lewy Body Disease, Parkinson’s

StudyFinds 4/15/2019

Why Some People Develop More Severe CTE Symptoms than Others

Association of American Universities 11/21/2018

Scientists zero in on genetic risk factor for Alzheimer's-like brain disease CTE

WBUR 11/5/2018

Specific Gene Variant Linked To Severe Symptoms Of CTE

UPI 11/5/2018

BU researchers make first link from severe CTE to genes

The Boston Globe 11/4/2018

Why Some People’s CTE Symptoms Are More Severe Than Others

BU Today 11/3/2018

Parkinson’s Symptoms Associated with Contact Sports

Genetic Engineering & Biotechnology News 7/26/2018
Contact for Mentoring:

150 S Huntington Avenue
Jamaica Plain MA 02130
Google Map

617.599.2684
Download vCard

Stein's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
See all (402) concept(s)
_
Media Mentions
_
Co-Authors
See all (85) people
_
Similar People
See all (60) people
_
Same Department
Search Department