Thor Stein, MD, PhD
Associate Professor
Boston University School of Medicine
Pathology & Laboratory Medicine

MD, University of Wisconsin Madison
PhD, University of Wisconsin Madison




Dr. Stein completed his undergraduate and graduate studies at the University of Wisconsin- Madison where he earned his MD and PhD (neuroscience) degrees. He completed residency training in pathology and fellowship training in neuropathology at Massachusetts General Hospital. In 2011 he became Assistant Professor of Pathology at Boston University School of Medicine.

Research Interests:
Dr. Stein’s research interests involve the study of neurodegenerative diseases, including Alzheimer disease and Amyotrophic Lateral Sclerosis (ALS). He studies the role of trauma in the abnormal accumulation of tau and proteins involved in RNA processing. He is an acting neuropathologist involved with the brain banks for the Boston University Alzheimer Disease Center, CTE Center, Framingham Heart Study, as well as the National Veterans Administration ALS brain bank.

CTE Center Role:
Dr. Stein is part of the Neuropathology Core of the SLI-BU CTE Brain Bank, where he conducts neuropathological analysis of brain tissue and helps maintain the SLI-BU CTE Brain Bank.

Awards/Memberships:
Dr. Stein is a recipient of the 2011 American Association of Neuropathologists Moore Award. He is a member of the Society for Neuroscience and the College of American Pathologists.

Investigator
Framingham Heart Study


VA Boston Healthcare System


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Data Call for ALS Biorepository Proposal
09/28/2020 - 09/27/2025 (Subcontract PI)
McKing Consulting Corporation HHS CDC


Age-Associated Lipidomic Changes in Alzheimer's Disease
02/01/2019 - 01/31/2024 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
1RF1AG057768-01A1

Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 08/31/2021 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
3RF1AG054156-01S1

Establishing a Biorepository of Amyotropic Lateral Sclerosis (ALS)
09/28/2016 - 09/27/2020 (Subcontract PI)
McKing Consulting Corporation HHS CDC ATSDR


Establishing a Biorepository of Amyotropic Lateral Sclerosis (ALS)
09/28/2015 - 09/27/2020 (Subcontract PI)
McKing Consulting Corporation HHS CDC ATSDR


Age-Associated Lipidomic Changes in Alzheimer's Disease
09/30/2017 - 01/31/2019 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
1R56AG057768-01

Personnel agreement for research services of Kerry Cormier
08/01/2015 - 07/31/2017 (PI)
Department of Veterans Administration, Bedford


ALS Brain Repository
06/01/2013 - 09/22/2016 (Subcontract PI)
McKing Consulting Corporation HHS CDC




Title
Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer


Yr Title Project-Sub Proj Pubs
2021 Role of classical complement pathway underling glial phenotypes and multiple pathologies in Alzheimer's disease and cerebrovascular disease 5U19AG068753-02-8041
2021 TBI-related polyproteinopathy and the role of multiple neurodegenerations in cognitive decline and parkinsonism 5U54NS115266-03-6602
2021 Age-Associated Lipidomic Changes in Alzheimer's Disease 3RF1AG057768-01A1S1 4
2021 The neuropathology of mild traumatic brain injury in Alzheimer disease 5I01CX001038-07 42
2020 Role of classical complement pathway underling glial phenotypes and multiple pathologies in Alzheimer's disease and cerebrovascular disease 1U19AG068753-01-8041
2020 TBI-related polyproteinopathy and the role of multiple neurodegenerations in cognitive decline and parkinsonism 5U54NS115266-02-6602
2020 The neuropathology of mild traumatic brain injury in Alzheimer disease 5I01CX001038-06 42
2019 Age-Associated Lipidomic Changes in Alzheimer's Disease 1RF1AG057768-01A1 4
2019 The neuropathology of mild traumatic brain injury in Alzheimer disease 2I01CX001038-05 42
2019 TBI-related polyproteinopathy and the role of multiple neurodegenerations in cognitive decline and parkinsonism 1U54NS115266-01-6602
Showing 10 of 21 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Panitch R, Hu J, Chung J, Zhu C, Meng G, Xia W, Bennett DA, Lunetta KL, Ikezu T, Au R, Stein TD, Farrer LA, Jun GR. Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE e2 protective effect in Alzheimer disease. Mol Psychiatry. 2021 Sep 03.View Related Profiles. PMID: 34480088
     
  2. Cherry JD, Agus F, Dixon E, Huber B, Alvarez VE, Mez J, McKee AC, Labadorf A, Stein TD. Differential gene expression in the cortical sulcus compared to the gyral crest within the early stages of chronic traumatic encephalopathy. Free Neuropathol. 2021; 2.View Related Profiles. PMID: 34485990; PMCID: PMC8415801; DOI: 10.17879/freeneuropathology-2021-3453;
     
  3. Iida MA, Farrell K, Walker JM, Richardson TE, Marx GA, Bryce CH, Purohit D, Ayalon G, Beach TG, Bigio EH, Cortes EP, Gearing M, Haroutunian V, McMillan CT, Lee EB, Dickson DW, McKee AC, Stein TD, Trojanowski JQ, Woltjer RL, Kovacs GG, Kofler JK, Kaye J, White CL, Crary JF. Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study. Acta Neuropathol Commun. 2021 08 05; 9(1):134.View Related Profiles. PMID: 34353357; PMCID: PMC8340493; DOI: 10.1186/s40478-021-01233-3;
     
  4. Gutierrez-Quiceno L, Dammer EB, Johnson AG, Webster JA, Shah R, Duong D, Yin L, Seyfried NT, Alvarez VE, Stein TD, McKee AC, Hales CM. A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy. Mol Neurodegener. 2021 06 25; 16(1):40.View Related Profiles. PMID: 34172091; PMCID: PMC8235576; DOI: 10.1186/s13024-021-00462-3;
     
  5. Anderson EN, Morera AA, Kour S, Cherry JD, Ramesh N, Gleixner A, Schwartz JC, Ebmeier C, Old W, Donnelly CJ, Cheng JP, Kline AE, Kofler J, Stein TD, Pandey UB. Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology. Elife. 2021 05 26; 10.View Related Profiles. PMID: 34060470; PMCID: PMC8169113; DOI: 10.7554/eLife.67587;
     
  6. Chancellor KB, Chancellor SE, Duke-Cohan JE, Huber BR, Stein TD, Alvarez VE, Okaty BW, Dymecki SM, McKee AC. Altered oligodendroglia and astroglia in chronic traumatic encephalopathy. Acta Neuropathol. 2021 08; 142(2):295-321.View Related Profiles. PMID: 34019156; PMCID: PMC8270845; DOI: 10.1007/s00401-021-02322-2;
     
  7. Cherry JD, Esnault CD, Baucom ZH, Tripodis Y, Huber BR, Alvarez VE, Stein TD, Dickson DW, McKee AC. Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer's disease. Acta Neuropathol Commun. 2021 05 12; 9(1):86.View Related Profiles. PMID: 33980303; PMCID: PMC8114683; DOI: 10.1186/s40478-021-01189-4;
     
  8. Fereshetian S, Agranat JS, Siegel N, Ness S, Stein TD, Subramanian ML. Protein and Imaging Biomarkers in the Eye for Early Detection of Alzheimer's Disease. J Alzheimers Dis Rep. 2021 May 03; 5(1):375-387.View Related Profiles. PMID: 34189409; PMCID: PMC8203283; DOI: 10.3233/ADR-210283;
     
  9. Loporchio DF, Tam EK, Cho J, Chung J, Jun GR, Xia W, Fiorello MG, Siegel NH, Ness S, Stein TD, Subramanian ML. Cytokine Levels in Human Vitreous in Proliferative Diabetic Retinopathy. Cells. 2021 04 30; 10(5).View Related Profiles. PMID: 33946446; PMCID: PMC8147162; DOI: 10.3390/cells10051069;
     
  10. Patel D, Zhang X, Farrell JJ, Chung J, Stein TD, Lunetta KL, Farrer LA. Cell-type-specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue. Transl Psychiatry. 2021 04 27; 11(1):250.View Related Profiles. PMID: 33907181; PMCID: PMC8079392; DOI: 10.1038/s41398-021-01373-z;
     
Showing 10 of 99 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 99 publications over 18 distinct years, with a maximum of 19 publications in 2020

YearPublications
20001
20023
20031
20042
20051
20081
20101
20114
20123
20133
20143
20159
20166
20175
201815
20199
202019
202113


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Parkinson’s Symptoms Associated with Contact Sports

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