Thor Stein, MD, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

MD, University of Wisconsin Madison
PhD, University of Wisconsin Madison
BS, University of Wisconsin Madison



Dr. Stein completed his undergraduate and graduate studies at the University of Wisconsin- Madison where he earned his MD and PhD (neuroscience) degrees. He completed residency training in pathology and fellowship training in neuropathology at Massachusetts General Hospital. In 2011 he became Assistant Professor of Pathology at Chobanian and Avedisian School of Medicine.

Research Interests:
Dr. Stein’s research interests involve the study of neurodegenerative diseases, including Alzheimer disease and Amyotrophic Lateral Sclerosis (ALS). He studies the role of trauma in the abnormal accumulation of tau and proteins involved in RNA processing. He is an acting neuropathologist involved with the brain banks for the Boston University Alzheimer Disease Center, CTE Center, Framingham Heart Study, as well as the National Veterans Administration ALS brain bank.

CTE Center Role:
Dr. Stein is part of the Neuropathology Core of the SLI-BU CTE Brain Bank, where he conducts neuropathological analysis of brain tissue and helps maintain the SLI-BU CTE Brain Bank.

Awards/Memberships:
Dr. Stein is a recipient of the 2011 American Association of Neuropathologists Moore Award. He is a member of the Society for Neuroscience and the College of American Pathologists.

Investigator
Framingham Heart Study


VA Boston Healthcare System


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Cerebrovascular Remodeling and Neurodegenerative Changes in Alzheimer's Disease
02/01/2022 - 01/31/2027 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
5R01AG075876-03

Boston University Alzheimer's Disease Research Center
08/15/2021 - 06/30/2026 (Key Person)
PI: Ann C. McKee, MD
NIH/National Institute on Aging
5P30AG072978-03

Identification and characterization of the CD31-ApoE-mCRP pathway for Alzheimer's disease in humans.
12/15/2022 - 11/30/2025 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
1RF1AG075832-01A1

Data Call for ALS Biorepository Proposal
09/28/2020 - 09/27/2025 (Subcontract PI)
McKing Consulting Corporation HHS CDC


Blood Biomarker Development and Validation in Chronic Traumatic Encephalopathy and Alzheimer's Disease and Alzheimer's Disease Related Dementias
06/01/2023 - 05/31/2025 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute of Neurological Disorders & Stroke
1RF1NS132290-01

Age-Associated Lipidomic Changes in Alzheimer's Disease
02/01/2019 - 08/31/2024 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
1RF1AG057768-01A1

Personnel Agreement for Research Services of Camille Esnault
09/30/2021 - 09/29/2022 (PI)
Department of Veterans Administration, Bedford


Personnel Agreement for Research Services of Lucas Fishbein
09/30/2021 - 09/29/2022 (PI)
Department of Veterans Administration, Bedford


Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 08/31/2021 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
3RF1AG054156-01S1

Establishing a Biorepository of Amyotropic Lateral Sclerosis (ALS)
09/28/2016 - 09/27/2020 (Subcontract PI)
McKing Consulting Corporation HHS CDC ATSDR


Showing 10 of 14 results. Show All Results


Title
Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
(PI)


Yr Title Project-Sub Proj Pubs
2024 Genetic and environmental modifiers of pathology in amyotrophic lateral sclerosis 5I01BX005161-02
2024 Cerebrovascular Remodeling and Neurodegenerative Changes in Alzheimer's Disease 5R01AG075876-03
2024 Role of classical complement pathway underling glial phenotypes and multiple pathologies in Alzheimer's disease and cerebrovascular disease 5U19AG068753-05-8065
2024 The neuropathology of mild traumatic brain injury in Alzheimer's disease 5I01BX005933-10
2023 Blood Biomarker Development and Validation in Chronic Traumatic Encephalopathy and Alzheimer's Disease and Alzheimer's Disease Related Dementias 1RF1NS132290-01
2023 Identification and characterization of the CD31-ApoE-mCRP pathway for Alzheimer's disease in humans. 1RF1AG075832-01A1
2023 Cerebrovascular Remodeling and Neurodegenerative Changes in Alzheimer's Disease 5R01AG075876-02
2023 Role of classical complement pathway underling glial phenotypes and multiple pathologies in Alzheimer's disease and cerebrovascular disease 5U19AG068753-04-8065
2023 Brain Bank Core 5U54NS115266-05-6541
2023 TBI-related polyproteinopathy and the role of multiple neurodegenerations in cognitive decline and parkinsonism 5U54NS115266-05-6544
Showing 10 of 36 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Frank B, Walsh M, Hurley L, Groh J, Blennow K, Zetterberg H, Tripodis Y, Budson AE, O'Connor MK, Martin B, Weller J, McKee A, Qiu W, Stein TD, Stern RA, Mez J, Henson R, Long J, Aschenbrenner AJ, Babulal GM, Morris JC, Schindler S, Alosco ML. Cognition Mediates the Association Between Cerebrospinal Fluid Biomarkers of Amyloid and P-Tau and Neuropsychiatric Symptoms. J Alzheimers Dis. 2024 Jul 06.View Related Profiles. PMID: 38995786
     
  2. Sahelijo N, Rajagopalan P, Qian L, Rahman R, Priyadarshi D, Goldstein D, Thomopoulos SI, Bennett DA, Farrer LA, Stein TD, Shen L, Huang H, Nho K, Andrew SJ, Davatzikos C, Thompson PM, Tcw J, Jun GR. Brain Cell-based Genetic Subtyping and Drug Repositioning for Alzheimer Disease. medRxiv. 2024 Jun 21.View Related Profiles. PMID: 38947056; PMCID: PMC11213108; DOI: 10.1101/2024.06.21.24309255;
     
  3. Culhane JE, Jackson CE, Tripodis Y, Nowinski CJ, Dams-O'Connor K, Pettway E, Uretsky M, Abdolmohammadi B, Nair E, Martin B, Palmisano J, Katz DI, Dwyer B, Daneshvar DH, Goldstein LE, Kowall NW, Cantu RC, Stern RA, Huber BR, Crary JF, Mez J, Stein TD, McKee AC, Alosco ML. Lack of Association of Informant-Reported Traumatic Brain Injury and Chronic Traumatic Encephalopathy. J Neurotrauma. 2024 Jun; 41(11-12):1399-1408.View Related Profiles. PMID: 38445389
     
  4. Wang Y, Huang J, Ang TFA, Zhu Y, Tao Q, Mez J, Alosco M, Denis GV, Belkina A, Gurnani A, Ross M, Gong B, Han J, Lunetta KL, Stein TD, Au R, Farrer LA, Zhang X, Qiu WQ. The association between circulating CD34+CD133+ endothelial progenitor cells and reduced risk of Alzheimer's disease in the Framingham Heart Study. Explor Med. 2024; 5(2):193-214.View Related Profiles. PMID: 38854406; PMCID: PMC11160969; DOI: 10.37349/emed.2024.00216;
     
  5. Butler MLMD, Pervaiz N, Ypsilantis P, Wang Y, Cammasola Breda J, Mazzilli S, Nicks R, Spurlock E, Hefti MM, Huber BR, Alvarez VE, Stein TD, Campbell JD, McKee AC, Cherry JD. Repetitive head impacts induce neuronal loss and neuroinflammation in young athletes. bioRxiv. 2024 Mar 28.View Related Profiles. PMID: 38585925; PMCID: PMC10996668; DOI: 10.1101/2024.03.26.586815;
     
  6. Panitch R, Sahelijo N, Hu J, Nho K, Bennett DA, Lunetta KL, Au R, Stein TD, Farrer LA, Jun GR. APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response. Transl Psychiatry. 2024 Feb 29; 14(1):129.View Related Profiles. PMID: 38424036; PMCID: PMC10904829; DOI: 10.1038/s41398-024-02834-x;
     
  7. Alexander A, Alvarez VE, Huber BR, Alosco ML, Mez J, Tripodis Y, Nicks R, Katz DI, Dwyer B, Daneshvar DH, Martin B, Palmisano J, Goldstein LE, Crary JF, Nowinski C, Cantu RC, Kowall NW, Stern RA, Delalle I, McKee AC, Stein TD. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta Neuropathol. 2024 Feb 26; 147(1):45.View Related Profiles. PMID: 38407651
     
  8. Alosco ML, White M, Bell C, Faheem F, Tripodis Y, Yhang E, Baucom Z, Martin B, Palmisano J, Dams-O'Connor K, Crary JF, Goldstein LE, Katz DI, Dwyer B, Daneshvar DH, Nowinski C, Cantu RC, Kowall NW, Stern RA, Alvarez VE, Huber BR, Stein TD, McKee AC, Mez J. Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy. Mol Neurodegener. 2024 Feb 06; 19(1):10.View Related Profiles. PMID: 38317248; PMCID: PMC10845638; DOI: 10.1186/s13024-023-00697-2;
     
  9. Bihn JR, Cioffi G, Waite KA, Kruchko C, Neff C, Price M, Ostrom QT, Swinnerton KN, Elbers DC, Mooney MA, Rachlin J, Stein TD, Brophy MT, Do NV, Ferguson RE, Priemer DS, Perl DP, Hickman RA, Nabors B, Rusiecki J, Barnholtz-Sloan JS, Fillmore NR. Brain tumors in United States military veterans. Neuro Oncol. 2024 Feb 02; 26(2):387-396.View Related Profiles. PMID: 37738677; PMCID: PMC10836768; DOI: 10.1093/neuonc/noad182;
     
  10. Montoliu-Gaya L, Alosco ML, Yhang E, Tripodis Y, Sconzo D, Ally M, Grötschel L, Ashton NJ, Lantero-Rodriguez J, Sauer M, Gomes B, Nilsson J, Brinkmalm G, Sugarman MA, Aparicio HJ, Martin B, Palmisano JN, Steinberg EG, Simkin I, Turk KW, Budson AE, Au R, Farrer L, Jun GR, Kowall NW, Stern RA, Goldstein LE, Qiu WQ, Mez J, Huber BR, Alvarez VE, McKee AC, Zetterberg H, Gobom J, Stein TD, Blennow K. Optimal blood tau species for the detection of Alzheimer's disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study. Acta Neuropathol. 2023 Dec 30; 147(1):5.View Related Profiles. PMID: 38159140; PMCID: PMC10757700; DOI: 10.1007/s00401-023-02660-3;
     
Showing 10 of 164 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 164 publications over 21 distinct years, with a maximum of 27 publications in 2023

YearPublications
20001
20023
20031
20042
20051
20081
20101
20114
20123
20133
20143
20159
20166
20175
201815
20199
202019
202123
202219
202327
20249


Recent (within 3 months)

Boston University CTE study finds link between contact sports, CTE, Parkinson's disease

Boston Herald 7/22/2024

Could Contact Sports Raise Risks for a Parkinson's-like Disorder?

CBS 19 News 7/17/2024

Parkinsonism in Athletes Linked With Chronic Traumatic Encephalopathy Pathology

Medpage Today 7/16/2024

Study reveals link between contact sports and parkinsons-like symptoms in CTE patients

Health Tech World 7/16/2024

New hit: Contact sport, CTE link to Parkinson's-style disease

WAToday 7/15/2024

What looks like Parkinson’s may not be in CTE patients

Boston 25 News 7/15/2024
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Playing tackle football at an early age increases risk for brain decline later

News Medical 3/20/2023

Active disease process in early CTE differs substantially from late-stage disease

News Medical 3/13/2023

Flag football grows in popularity due to head injury concerns

CBS News 3/7/2023

New BU Study Finds Tackle Football at Young Age Raises Risk for Brain Decline Later

The Brink 3/6/2023

They Made History at Alabama. But Football Stardom Had a Price.

The New York Times 8/7/2022

Medical Campus Promotes 13 Faculty to Associate Professor

BU Today 7/30/2021

How CTE contributed to the death of a beloved Bolivar attorney, star athlete

The Springfielf News-Leader 3/25/2021

Troubling Sleep Disorder in Athletes a Sign of CTE?

Medscape 9/30/2020

Boston University research shows rare sleep disorder impacts contact sport athletes

WCVB-TV 9/17/2020

CTE, Contact Sports Play Linked to REM Sleep Behavior Disorder

BU Today 9/16/2020

Boston University researchers discover link between CTE and severe sleep disorder

WHDH-TV 9/16/2019

Tau Pathology Present Decades After a Single Brain Injury

The Scientist 9/9/2019

Study: Playing Contact Sports Significantly Increases Risk Of Lewy Body Disease, Parkinson’s

StudyFinds 4/15/2019

Why Some People Develop More Severe CTE Symptoms than Others

Association of American Universities 11/21/2018

Scientists zero in on genetic risk factor for Alzheimer's-like brain disease CTE

WBUR 11/5/2018

Specific Gene Variant Linked To Severe Symptoms Of CTE

UPI 11/5/2018

BU researchers make first link from severe CTE to genes

The Boston Globe 11/4/2018

Why Some People’s CTE Symptoms Are More Severe Than Others

BU Today 11/3/2018

Parkinson’s Symptoms Associated with Contact Sports

Genetic Engineering & Biotechnology News 7/26/2018
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