Thor Stein, MD, PhD
Assistant Professor
Boston University School of Medicine
Dept of Pathology & Laboratory Medicine

MD, University of Wisconsin Madison
PhD, University of Wisconsin Madison




Dr. Stein completed his undergraduate and graduate studies at the University of Wisconsin- Madison where he earned his MD and PhD (neuroscience) degrees. He completed residency training in pathology and fellowship training in neuropathology at Massachusetts General Hospital. In 2011 he became Assistant Professor of Pathology at Boston University School of Medicine.

Research Interests:
Dr. Stein’s research interests involve the study of neurodegenerative diseases, including Alzheimer disease and Amyotrophic Lateral Sclerosis (ALS). He studies the role of trauma in the abnormal accumulation of tau and proteins involved in RNA processing. He is an acting neuropathologist involved with the brain banks for the Boston University Alzheimer Disease Center, CTE Center, Framingham Heart Study, as well as the National Veterans Administration ALS brain bank.

CTE Center Role:
Dr. Stein is part of the Neuropathology Core of the SLI-BU CTE Brain Bank, where he conducts neuropathological analysis of brain tissue and helps maintain the SLI-BU CTE Brain Bank.

Awards/Memberships:
Dr. Stein is a recipient of the 2011 American Association of Neuropathologists Moore Award. He is a member of the Society for Neuroscience and the College of American Pathologists.

VA Boston Healthcare System




Age-Associated Lipidomic Changes in Alzheimer's Disease
02/01/2019 - 11/30/2023 (Co-PI)
PI: Jan K. Blusztajn, PhD
NIH/National Institute on Aging
1R01AG057768-01A1

Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer
09/15/2016 - 06/30/2021 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
3RF1AG054156-01S1

Establishing a Biorepository of Amyotropic Lateral Sclerosis (ALS)
09/28/2015 - 09/27/2020 (PI)
McKing Consulting Corporation HHS/CDC/ATSDR


Establishing a Biorepository of Amyotropic Lateral Sclerosis (ALS)
09/28/2016 - 09/27/2019 (PI)
McKing Consulting Corporation HHS/CDC/ATSDR


Age-Associated Lipidomic Changes in Alzheimer's Disease
09/30/2017 - 01/31/2019 (Multi-PI)
PI: Thor Stein, MD, PhD
NIH/National Institute on Aging
1R56AG057768-01

Personnel Agreement for Research Services of Kerry Cormier
08/01/2015 - 07/31/2017 (PI)
Department of Veterans Administration, Bedford


ALS Brain Repository
06/01/2013 - 09/22/2016 (PI)
McKing Consulting Corporation HHS CDC





Yr Title Project-Sub Proj Pubs
2019 Age-Associated Lipidomic Changes in Alzheimer's Disease 1R01AG057768-01A1
2019 The neuropathology of mild traumatic brain injury in Alzheimer disease 2I01CX001038-05 28
2018 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies and cognitive decline 3RF1AG054156-01S1 8
2018 The neuropathology of mild traumatic brain injury in Alzheimer's disease 5I01CX001038-04 28
2017 Age-Associated Lipidomic Changes in Alzheimer's Disease 1R56AG057768-01 4
2017 The neuropathology of mild traumatic brain injury in Alzheimer's disease 5I01CX001038-03 28
2017 VA Biorepository Brain Bank 5I01BX002466-04 5
2016 Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive decline 1RF1AG054156-01 8
2016 The neuropathology of mild traumatic brain injury in Alzheimer's disease 5I01CX001038-02 28
2016 VA Biorepository Brain Bank 5I01BX002466-03 5
Showing 10 of 13 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Standring OJ, Friedberg J, Tripodis Y, Chua AS, Cherry JD, Alvarez VE, Huber BR, Xia W, Mez J, Alosco ML, Nicks R, Mahar I, Pothast MJ, Gardner HM, Meng G, Palmisano JN, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, McKee AC, Stein TD. Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy. Acta Neuropathol. 2019 Jun 10.View Related Profiles. PMID: 31183671.
     
  2. Sugarman MA, McKee AC, Stein TD, Tripodis Y, Besser LM, Martin B, Palmisano JN, Steinberg EG, O'Connor MK, Au R, McClean M, Killiany R, Mez J, Weiner MW, Kowall NW, Stern RA, Alosco ML. Failure to detect an association between self-reported traumatic brain injury and Alzheimer's disease neuropathology and dementia. Alzheimers Dement. 2019 May; 15(5):686-698.View Related Profiles. PMID: 30852157; DOI: 10.1016/j.jalz.2018.12.015;.
     
  3. Signaevsky M, Prastawa M, Farrell K, Tabish N, Baldwin E, Han N, Iida MA, Koll J, Bryce C, Purohit D, Haroutunian V, McKee AC, Stein TD, White CL, Walker J, Richardson TE, Hanson R, Donovan MJ, Cordon-Cardo C, Zeineh J, Fernandez G, Crary JF. Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy. Lab Invest. 2019 Feb 15.View Related Profiles. PMID: 30770886.
     
  4. Wright LM, Stein TD, Jun G, Chung J, McConnell K, Fiorello M, Siegel N, Ness S, Xia W, Turner KL, Subramanian ML. Association of Cognitive Function with Amyloid-ß and Tau Proteins in the Vitreous Humor. J Alzheimers Dis. 2019; 68(4):1429-1438.View Related Profiles. PMID: 30856114.
     
  5. Armstrong RA, McKee AC, Stein TD, Alvarez VE, Cairns NJ. Cortical degeneration in chronic traumatic encephalopathy and Alzheimer's disease neuropathologic change. Neurol Sci. 2019 Mar; 40(3):529-533.View Related Profiles. PMID: 30564964.
     
  6. Walt GS, Burris HM, Brady CB, Spencer KR, Alvarez VE, Huber BR, Guilderson L, Abdul Rauf N, Collins D, Singh T, Mathias R, Averill JG, Walker SE, Robey I, McKee AC, Kowall NW, Stein TD. Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort. J Neuropathol Exp Neurol. 2018 Dec 01; 77(12):1091-1100.View Related Profiles. PMID: 30299493.
     
  7. Cherry JD, Mez J, Crary JF, Tripodis Y, Alvarez VE, Mahar I, Huber BR, Alosco ML, Nicks R, Abdolmohammadi B, Kiernan PT, Evers L, Svirsky S, Babcock K, Gardner HM, Meng G, Nowinski CJ, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Farrer LA, McKee AC, Stein TD. Variation in TMEM106B in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2018 11 04; 6(1):115.View Related Profiles. PMID: 30390709.
     
  8. Morrison FG, Miller MW, Wolf EJ, Logue MW, Maniates H, Kwasnik D, Cherry JD, Svirsky S, Restaino A, Hildebrandt A, Aytan N, Stein TD, Alvarez VE, McKee AC, Huber BR. Reduced interleukin 1A gene expression in the dorsolateral prefrontal cortex of individuals with PTSD and depression. Neurosci Lett. 2019 01 23; 692:204-209.View Related Profiles. PMID: 30366016.
     
  9. Tao Q, Ang TFA, DeCarli C, Auerbach SH, Devine S, Stein TD, Zhang X, Massaro J, Au R, Qiu WQ. Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers. JAMA Netw Open. 2018 Oct 05; 1(6):e183597.View Related Profiles. PMID: 30646251.
     
  10. Hsu ET, Gangolli M, Su S, Holleran L, Stein TD, Alvarez VE, McKee AC, Schmidt RE, Brody DL. Astrocytic degeneration in chronic traumatic encephalopathy. Acta Neuropathol. 2018 12; 136(6):955-972.View Related Profiles. PMID: 30194648.
     
Showing 10 of 62 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 61 publications over 16 distinct years, with a maximum of 15 publications in 2018

YearPublications
20001
20023
20031
20042
20051
20081
20101
20114
20123
20133
20143
20159
20166
20175
201815
20193
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Recent (within 3 months)

Study: Playing Contact Sports Significantly Increases Risk Of Lewy Body Disease, Parkinson’s

StudyFinds 4/15/2019
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Why Some People Develop More Severe CTE Symptoms than Others

Association of American Universities 11/21/2018

Scientists zero in on genetic risk factor for Alzheimer's-like brain disease CTE

WBUR 11/5/2018

Specific Gene Variant Linked To Severe Symptoms Of CTE

UPI 11/5/2018

BU researchers make first link from severe CTE to genes

The Boston Globe 11/4/2018

Why Some People’s CTE Symptoms Are More Severe Than Others

BU Today 11/3/2018

Parkinson’s Symptoms Associated with Contact Sports

Genetic Engineering & Biotechnology News 7/26/2018

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