Kathryn L Lunetta, PhD
Professor
Boston University School of Public Health
Biostatistics

PhD, University of Michigan at Ann Arbor
MS, University of Michigan at Ann Arbor
BA, Grinnell College

Pronouns: she/her/hers



Kathryn L. Lunetta, Ph.D. is a Professor of Biostatistics and a statistical geneticist with more than 20 years of experience in statistics and genetics research. She has extensive experience with the design and analysis of genome- wide association studies and sequencing studies and collaborate on several large, national and international genetic epidemiology studies at Boston University and with the Framingham Heart study. Her methodological research focuses on statistical problems and study design and analysis issues in human genetics, particularly in the mapping of complex genetic diseases. Her collaborative work spans several fields, including the genetics of atrial fibrillation and related phenotypes, the genetics of healthy aging and reproduction, and Alzheimer disease. She is a member of the CHARGE (Cohorts for Heart and Aging Research) consortium and participates on the Steering and Analysis committees, and also a TOPMed investigator and analysis committee member. She is senior/primary statistician on several Alzheimer Disease related projects and for the Framingham Heart Study Atrial Fibrillation working groups, where she advises on methodology and long-term goals and provide day- to-day supervision of analyses. She is multi-PI of a Framingham Immune cell and brain aging project that seeks to identify immune cell and inflammatory biomarkers related to cognitive aging.

Diversity, Equity, Inclusion and Accessibility

To improve DEIJ in admissions, I have worked with others to revise our admissions rubrics to be more holistic, with the goal of increasing the diversity of our student body.
In my teaching, I have worked to find new genetic data sets that are less European ancestry-centric, and revised language to reflect current/changing best practices. In my research, I have mentored one of my students to focus her research on methods to ameliorate the effects of lack of diverse representation in genetic studies on underrepresented populations through improved statistical methods, while at the same time advocating for the improved representation that is of critical importance.

Investigator
Framingham Heart Study


Member
Boston University
Genome Science Institute


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Identification of Common Genetic Variants for Atrial Fibrillation and PR Interval
04/01/2022 - 03/31/2027 (Multi-PI)
PI: Kathryn L Lunetta, PhD
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NHLBI
2R01HL092577-14

BUSPH Interdisciplinary Training Program for Biostatisticians
07/01/2021 - 06/30/2026 (Multi-PI)
PI: Kathryn L Lunetta, PhD
NIH/National Institute of General Medical Sciences
5T32GM140972-03

Using Electrocardiogram Genetics to Inform Arrhythmia Risk
01/20/2022 - 12/31/2025 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NHLBI
5R01HL157635-02

CHARGE consortium: omics discovery for CVD and aging phenotypes
08/01/2022 - 06/30/2025 (Subcontract PI)
University of Washington NIH NHLBI
2R01HL105756-11

Role of peripheral immune cells in cognitive aging: The Framingham Offspring Study
04/15/2020 - 03/31/2025 (Multi-PI)
PI: Kathryn L Lunetta, PhD
NIH/National Institute on Aging
5R01AG067457-04

Winter 2018 CENTER strategically focused Atrial Fibrillation Research Network
07/01/2018 - 06/30/2024 (Multi-PI)
PI: Kathryn L Lunetta, PhD
American Heart Association


Novel Statistical Methods for Development of Polygenic Scores in Multi-Ancestry Cohorts
05/01/2022 - 04/30/2024 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute
5F31HL163952-02

Identification of Common Genetic Variants for Atrial Fibrillation and PR Interval
04/01/2018 - 03/31/2023 (Co-Investigator)
PI: Emelia J. Benjamin, MD, ScM
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NHLBI
5R01HL092577-13

CHARGE (Cohorts for Heart and Aging Research) Consortium: Gene discovery for CVD and aging phenotypes
07/15/2018 - 07/31/2022 (Subcontract PI)
University of Washington NIH NHLBI
5R01HL105756-10

Genetics and Epigenetics of Atrial Fibrillation
07/01/2018 - 06/30/2022 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital American Heart Assoc


Showing 10 of 17 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2023 BUSPH Interdisciplinary Training Program for Biostatisticians 5T32GM140972-03
2023 Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring Study 5R01AG067457-04
2023 IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL 5R01HL092577-15
2022 BUSPH Interdisciplinary Training Program for Biostatisticians 5T32GM140972-02
2022 Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring Study 5R01AG067457-03
2022 IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL 2R01HL092577-14
2021 BUSPH Interdisciplinary Training Program for Biostatisticians 1T32GM140972-01
2021 Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring Study 5R01AG067457-02
2021 IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL 5R01HL092577-13 241
2020 Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring Study 1R01AG067457-01
Showing 10 of 25 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Ochs-Balcom HM, Preus L, Du Z, Elston RC, Teerlink CC, Jia G, Guo X, Cai Q, Long J, Ping J, Li B, Stram DO, Shu XO, Sanderson M, Gao G, Ahearn T, Lunetta KL, Zirpoli G, Troester MA, Ruiz-Narváez EA, Haddad SA, Figueroa J, John EM, Bernstein L, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Mancuso N, Press MF, Deming SL, Rodriguez-Gil JL, Yao S, Ogundiran TO, Ojengbede O, Bolla MK, Dennis J, Dunning AM, Easton DF, Michailidou K, Pharoah PDP, Sandler DP, Taylor JA, Wang Q, O'Brien KM, Weinberg CR, Kitahara CM, Blot W, Nathanson KL, Hennis A, Nemesure B, Ambs S, Sucheston-Campbell LE, Bensen JT, Chanock SJ, Olshan AF, Ambrosone CB, Olopade OI, Conti DV, Palmer J, García-Closas M, Huo D, Zheng W, Haiman C. Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia. Hum Mol Genet. 2024 Jan 23.View Related Profiles. PMID: 38263910
     
  2. Zirpoli GR, Pfeiffer RM, Bertrand KA, Huo D, Lunetta KL, Palmer JR. Addition of polygenic risk score to a risk calculator for prediction of breast cancer in US Black women. Breast Cancer Res. 2024 Jan 02; 26(1):2.View Related Profiles. PMID: 38167144; PMCID: PMC10763003; DOI: 10.1186/s13058-023-01748-8;
     
  3. Ragab AAY, Doyle MF, Chen J, Fang Y, Lunetta KL, Murabito JM. Aging-Related Immune Cell Phenotypes and Mortality in the Framingham Heart Study. Res Sq. 2023 Dec 26.View Related Profiles. PMID: 38234796; PMCID: PMC10793514; DOI: 10.21203/rs.3.rs-3773986/v1;
     
  4. Zheng Y, Lunetta KL, Liu C, Smith AK, Sherva R, Miller MW, Logue MW. A novel principal component based method for identifying differentially methylated regions in Illumina Infinium MethylationEPIC BeadChip data. Epigenetics. 2023 Dec; 18(1):2207959.View Related Profiles. PMID: 37196182; PMCID: PMC10193914; DOI: 10.1080/15592294.2023.2207959;
     
  5. Tao Q, Zhang C, Mercier G, Lunetta K, Ang TFA, Akhter-Khan S, Zhang Z, Taylor A, Killiany RJ, Alosco M, Mez J, Au R, Zhang X, Farrer LA, Qiu WWQ. Identification of an APOE e4-specific blood-based molecular pathway for Alzheimer's disease risk. Alzheimers Dement (Amst). 2023; 15(4):e12490.View Related Profiles. PMID: 37854772; PMCID: PMC10579631; DOI: 10.1002/dad2.12490;
     
  6. Huang J, Wang Y, Stein TD, Ang TFA, Zhu Y, Tao Q, Lunetta KL, Mez J, Au R, Farrer LA, Qiu WQ, Zhang X. The impact of blood MCP-1 levels on Alzheimer's disease with genetic variation of UNC5C and NAV3 loci. Res Sq. 2023 Sep 28.View Related Profiles. PMID: 37841863; PMCID: PMC10571626; DOI: 10.21203/rs.3.rs-3376348/v1;
     
  7. Chen J, Doyle MF, Fang Y, Mez J, Crane PK, Scollard P, Satizabal CL, Alosco ML, Qiu WQ, Murabito JM, Lunetta KL. Peripheral inflammatory biomarkers are associated with cognitive function and dementia: Framingham Heart Study Offspring cohort. Aging Cell. 2023 Oct; 22(10):e13955.View Related Profiles. PMID: 37584418; PMCID: PMC10577533; DOI: 10.1111/acel.13955;
     
  8. Fang Y, Doyle MF, Chen J, Mez J, Satizabal CL, Alosco ML, Qiu WQ, Lunetta KL, Murabito JM. Correction for: Circulating immune cell phenotypes are associated with age, sex, CMV, and smoking status in the Framingham Heart Study offspring participants. Aging (Albany NY). 2023 Aug 14; 15(15):7855-7856.View Related Profiles. PMID: 37580144; PMCID: PMC10457073; DOI: 10.18632/aging.204988;
     
  9. Tejeda M, Farrell J, Zhu C, Wetzler L, Lunetta KL, Bush WS, Martin ER, Wang LS, Schellenberg GD, Pericak-Vance MA, Haines JL, Farrer LA, Sherva R. DNA from multiple viral species is associated with Alzheimer's disease risk. Alzheimers Dement. 2024 Jan; 20(1):253-265.View Related Profiles. PMID: 37578203; PMCID: PMC10840621; DOI: 10.1002/alz.13414;
     
  10. Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, Lucio da Fonseca E, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Iqbal T, Pathak O, Valladares O, Kuzma AB, Abner E, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ERR, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, Wingo TS, Wisniewski T, Woltjer RL, Woon M, Wright CB, Wu CK, Younkin SG, Yu CE, Yu L, Zhu X, Kunkle BW, Bush WS, Wang LS, Farrer LA, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Jun GR, Reitz C, Naj AC. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. medRxiv. 2023 Jul 08.View Related Profiles. PMID: 37461624; PMCID: PMC10350126; DOI: 10.1101/2023.07.06.23292311;
     
Showing 10 of 310 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 309 publications over 32 distinct years, with a maximum of 27 publications in 2017

YearPublications
19911
19922
19941
19953
19963
19972
19982
19993
20005
20015
20021
20041
20054
20062
20079
20089
200911
201012
201116
201214
201317
201418
201517
201622
201727
201816
201919
20209
202119
202218
202319
20242

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Statistical genetics
Genetic Epidemiology
Healthy Aging
Atrial Fibrillation
Alzheimer's Disease
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801 Massachusetts Ave Crosstown Center
Boston MA 02118
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