Kathryn L Lunetta, PhD
Professor
Boston University School of Public Health
Biostatistics

PhD, University of Michigan at Ann Arbor
MS, University of Michigan at Ann Arbor
BA, Grinnell College

Pronouns: she/her/hers



Kathryn L. Lunetta, Ph.D. is a Professor of Biostatistics and a statistical geneticist with more than 20 years of experience in statistics and genetics research. She has extensive experience with the design and analysis of genome- wide association studies and sequencing studies and collaborate on several large, national and international genetic epidemiology studies at Boston University and with the Framingham Heart study. Her methodological research focuses on statistical problems and study design and analysis issues in human genetics, particularly in the mapping of complex genetic diseases. Her collaborative work spans several fields, including the genetics of atrial fibrillation and related phenotypes, the genetics of healthy aging and reproduction, and Alzheimer disease. She is a member of the CHARGE (Cohorts for Heart and Aging Research) consortium and participates on the Steering and Analysis committees, and also a TOPMed investigator and analysis committee member. She is senior/primary statistician on several Alzheimer Disease related projects and for the Framingham Heart Study Atrial Fibrillation working groups, where she advises on methodology and long-term goals and provide day- to-day supervision of analyses. She is multi-PI of a Framingham Immune cell and brain aging project that seeks to identify immune cell and inflammatory biomarkers related to cognitive aging.

Diversity, Equity, Inclusion and Accessibility

To improve DEIJ in admissions, I have worked with others to revise our admissions rubrics to be more holistic, with the goal of increasing the diversity of our student body.
In my teaching, I have worked to find new genetic data sets that are less European ancestry-centric, and revised language to reflect current/changing best practices. In my research, I have mentored one of my students to focus her research on methods to ameliorate the effects of lack of diverse representation in genetic studies on underrepresented populations through improved statistical methods, while at the same time advocating for the improved representation that is of critical importance.

Investigator
Framingham Heart Study


Member
Boston University
Genome Science Institute


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Identification of Common Genetic Variants for Atrial Fibrillation and PR Interval
04/01/2022 - 03/31/2027 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NHLBI
2R01HL092577-14

BUSPH Interdisciplinary Training Program for Biostatisticians
07/01/2021 - 06/30/2026 (Multi-PI)
PI: Kathryn L Lunetta, PhD
NIH/National Institute of General Medical Sciences
5T32GM140972-02

Using Electrocardiogram Genetics to Inform Arrhythmia Risk
01/20/2022 - 12/31/2025 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NHLBI
5R01HL157635-02

CHARGE consortium: omics discovery for CVD and aging phenotypes
08/01/2022 - 06/30/2025 (Subcontract PI)
University of Washington NIH NHLBI
2R01HL105756-11

Role of peripheral immune cells in cognitive aging: The Framingham Offspring Study
04/15/2020 - 03/31/2025 (Multi-PI)
PI: Kathryn L Lunetta, PhD
NIH/National Institute on Aging
5R01AG067457-04

Winter 2018 CENTER strategically focused Atrial Fibrillation Research Network
07/01/2018 - 06/30/2024 (Multi-PI)
PI: Kathryn L Lunetta, PhD
American Heart Association


Novel Statistical Methods for Development of Polygenic Scores in Multi-Ancestry Cohorts
05/01/2022 - 04/30/2024 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute
1F31HL163952-01

Identification of Common Genetic Variants for Atrial Fibrillation and PR Interval
04/01/2018 - 03/31/2023 (Co-Investigator)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NHLBI
5R01HL092577-13

CHARGE (Cohorts for Heart and Aging Research) Consortium: Gene discovery for CVD and aging phenotypes
07/15/2018 - 07/31/2022 (Subcontract PI)
University of Washington NIH NHLBI
5R01HL105756-10

Genetics and Epigenetics of Atrial Fibrillation
07/01/2018 - 06/30/2022 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital American Heart Assoc


Showing 10 of 17 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2023 Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring Study 5R01AG067457-04
2023 IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL 5R01HL092577-15
2022 BUSPH Interdisciplinary Training Program for Biostatisticians 5T32GM140972-02
2022 Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring Study 5R01AG067457-03
2022 IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL 2R01HL092577-14
2021 BUSPH Interdisciplinary Training Program for Biostatisticians 1T32GM140972-01
2021 Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring Study 5R01AG067457-02
2021 IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL 5R01HL092577-13 241
2020 Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring Study 1R01AG067457-01
2020 IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL 5R01HL092577-12 241
Showing 10 of 24 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Zheng Y, Lunetta KL, Liu C, Smith AK, Sherva R, Miller MW, Logue MW. A novel principal component based method for identifying differentially methylated regions in Illumina Infinium MethylationEPIC BeadChip data. Epigenetics. 2023 Dec; 18(1):2207959.View Related Profiles. PMID: 37196182; PMCID: PMC10193914; DOI: 10.1080/15592294.2023.2207959;
     
  2. Ilozumba MN, Yaghjyan L, Datta S, Zhao J, Hong CC, Lunetta KL, Zirpoli G, Bandera EV, Palmer JR, Yao S, Ambrosone CB, Cheng TD. mTOR pathway candidate genes and energy intake interaction on breast cancer risk in Black women from the Women's Circle of Health Study. Eur J Nutr. 2023 May 20.View Related Profiles. PMID: 37209192
     
  3. Fang Y, Doyle MF, Chen J, Mez J, Satizabal CL, Alosco ML, Qiu WQ, Lunetta KL, Murabito JM. Circulating immune cell phenotypes are associated with age, sex, CMV, and smoking status in the Framingham Heart Study offspring participants. Aging (Albany NY). 2023 Apr 27; 15.View Related Profiles. PMID: 37116193
     
  4. Jurgens SJ, Pirruccello JP, Choi SH, Morrill VN, Chaffin M, Lubitz SA, Lunetta KL, Ellinor PT. Adjusting for common variant polygenic scores improves yield in rare variant association analyses. Nat Genet. 2023 Apr; 55(4):544-548. PMID: 36959364
     
  5. Jurgens SJ, Pirruccello JP, Choi SH, Morrill VN, Chaffin M, Lubitz SA, Lunetta KL, Ellinor PT. Adjusting for common variant polygenic scores improves yield in rare variant association analyses. Nat Genet. 2023 Mar 23. PMID: 36959364
     
  6. Ilozumba MN, Yaghjyan L, Datta S, Zhao J, Gong Z, Hong CC, Lunetta KL, Zirpoli G, Bandera EV, Palmer JR, Yao S, Ambrosone CB, Cheng TD. mTOR pathway candidate genes and physical activity interaction on breast cancer risk in black women from the women's circle of health study. Breast Cancer Res Treat. 2023 May; 199(1):137-146.View Related Profiles. PMID: 36882608
     
  7. Ilozumba MN, Yaghjyan L, Datta S, Zhao J, Hong CC, Lunetta KL, Zirpoli G, Bandera EV, Palmer JR, Yao S, Ambrosone CB, Cheng TD. mTOR pathway candidate genes and obesity interaction on breast cancer risk in black women from the Women's Circle of Health Study. Cancer Causes Control. 2023 May; 34(5):431-447.View Related Profiles. PMID: 36790512
     
  8. Wang Y, Huang J, Ang TFA, Zhu Y, Tao Q, Mez J, Alosco M, Denis GV, Belkina A, Gurnani A, Ross M, Gong B, Han J, Lunetta KL, Stein TD, Au R, Farrer LA, Zhang X, Qiu WQ. Circulating Endothelial Progenitor Cells Reduce the Risk of Alzheimer's Disease. medRxiv. 2023 Jan 18.View Related Profiles. PMID: 36711847; PMCID: PMC9882408; DOI: 10.1101/2023.01.16.23284571;
     
  9. Huang J, Tao Q, Ang TFA, Farrell J, Zhu C, Wang Y, Stein TD, Lunetta KL, Massaro J, Mez J, Au R, Farrer LA, Qiu WQ, Zhang X. The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in Alzheimer's disease. Transl Psychiatry. 2022 Dec 22; 12(1):523.View Related Profiles. PMID: 36550123; PMCID: PMC9780312; DOI: 10.1038/s41398-022-02281-6;
     
  10. Huang J, Stein TD, Wang Y, Ang TFA, Tao Q, Lunetta KL, Massaro J, Akhter-Khan SC, Mez J, Au R, Farrer LA, Zhang X, Qiu WQ. Blood levels of MCP-1 modulate the genetic risks of Alzheimer's disease mediated by HLA-DRB1 and APOE for Alzheimer's disease. Alzheimers Dement. 2023 May; 19(5):1925-1937.View Related Profiles. PMID: 36396603; PMCID: PMC10182187; DOI: 10.1002/alz.12851;
     
Showing 10 of 296 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 295 publications over 31 distinct years, with a maximum of 27 publications in 2017

YearPublications
19911
19922
19941
19953
19963
19972
19982
19993
20005
20015
20021
20041
20054
20062
20079
20089
200911
201012
201116
201214
201317
201418
201517
201622
201727
201816
201919
20209
202119
202218
20237

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Statistical genetics
Genetic Epidemiology
Healthy Aging
Atrial Fibrillation
Alzheimer's Disease
Contact for Mentoring:

801 Massachusetts Ave Crosstown Center
Boston MA 02118
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