Kathryn L Lunetta, PhD
Professor
Boston University School of Public Health
Biostatistics

PhD, University of Michigan at Ann Arbor
MS, University of Michigan at Ann Arbor
BA, Grinnell College

Pronouns: she/her/hers



Kathryn L. Lunetta, Ph.D. is a Professor of Biostatistics and a statistical geneticist with more than 20 years of experience in statistics and genetics research. She has extensive experience with the design and analysis of genome- wide association studies and sequencing studies and collaborate on several large, national and international genetic epidemiology studies at Boston University and with the Framingham Heart study. Her methodological research focuses on statistical problems and study design and analysis issues in human genetics, particularly in the mapping of complex genetic diseases. Her collaborative work spans several fields, including the genetics of atrial fibrillation and related phenotypes, the genetics of healthy aging and reproduction, and Alzheimer disease. She is a member of the CHARGE (Cohorts for Heart and Aging Research) consortium and participates on the Steering and Analysis committees, and also a TOPMed investigator and analysis committee member. She is senior/primary statistician on several Alzheimer Disease related projects and for the Framingham Heart Study Atrial Fibrillation working groups, where she advises on methodology and long-term goals and provide day- to-day supervision of analyses. She is multi-PI of a Framingham Immune cell and brain aging project that seeks to identify immune cell and inflammatory biomarkers related to cognitive aging.

Diversity, Equity, Inclusion and Accessibility

To improve DEIJ in admissions, I have worked with others to revise our admissions rubrics to be more holistic, with the goal of increasing the diversity of our student body.
In my teaching, I have worked to find new genetic data sets that are less European ancestry-centric, and revised language to reflect current/changing best practices. In my research, I have mentored one of my students to focus her research on methods to ameliorate the effects of lack of diverse representation in genetic studies on underrepresented populations through improved statistical methods, while at the same time advocating for the improved representation that is of critical importance.

Investigator
Framingham Heart Study


Member
Boston University
Genome Science Institute


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Identification of Common Genetic Variants for Atrial Fibrillation and PR Interval
04/01/2022 - 03/31/2027 (Multi-PI)
PI: Kathryn L Lunetta, PhD
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NHLBI
5R01HL092577-16

BUSPH Interdisciplinary Training Program for Biostatisticians
07/01/2021 - 06/30/2026 (Multi-PI)
PI: Kathryn L Lunetta, PhD
NIH/National Institute of General Medical Sciences
5T32GM140972-03

Using Electrocardiogram Genetics to Inform Arrhythmia Risk
01/20/2022 - 12/31/2025 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NHLBI
5R01HL157635-03

CHARGE consortium: omics discovery for CVD and aging phenotypes
08/01/2022 - 06/30/2025 (Subcontract PI)
University of Washington NIH NHLBI
5R01HL105756-12

Role of peripheral immune cells in cognitive aging: The Framingham Offspring Study
04/15/2020 - 03/31/2025 (Multi-PI)
PI: Kathryn L Lunetta, PhD
NIH/National Institute on Aging
5R01AG067457-05

Winter 2018 CENTER strategically focused Atrial Fibrillation Research Network
07/01/2018 - 06/30/2024 (Multi-PI)
PI: Kathryn L Lunetta, PhD
American Heart Association


Novel Statistical Methods for Development of Polygenic Scores in Multi-Ancestry Cohorts
05/01/2022 - 04/30/2024 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute
5F31HL163952-02

Identification of Common Genetic Variants for Atrial Fibrillation and PR Interval
04/01/2018 - 03/31/2023 (Co-Investigator)
PI: Emelia J. Benjamin, MD, ScM
The General Hospital Corporation d/b/a Massachusetts General Hospital NIH NHLBI
5R01HL092577-13

CHARGE (Cohorts for Heart and Aging Research) Consortium: Gene discovery for CVD and aging phenotypes
07/15/2018 - 07/31/2022 (Subcontract PI)
University of Washington NIH NHLBI
5R01HL105756-10

Genetics and Epigenetics of Atrial Fibrillation
07/01/2018 - 06/30/2022 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital American Heart Assoc


Showing 10 of 17 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2024 BUSPH Interdisciplinary Training Program for Biostatisticians 5T32GM140972-04
2024 Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring Study 5R01AG067457-05
2024 IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL 5R01HL092577-16
2023 BUSPH Interdisciplinary Training Program for Biostatisticians 5T32GM140972-03
2023 Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring Study 5R01AG067457-04
2023 IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL 5R01HL092577-15
2022 BUSPH Interdisciplinary Training Program for Biostatisticians 5T32GM140972-02
2022 Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring Study 5R01AG067457-03
2022 IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL 2R01HL092577-14
2021 BUSPH Interdisciplinary Training Program for Biostatisticians 1T32GM140972-01
Showing 10 of 28 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Tong T, Zhu C, Farrell JJ, Khurshid Z, Martin ER, Pericak-Vance MA, Wang LS, Bush WS, Schellenberg GD, Haines JL, Qiu WQ, Lunetta KL, Farrer LA, Zhang X. Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites. Alzheimers Res Ther. 2024 Oct 23; 16(1):234.View Related Profiles. PMID: 39444005; PMCID: PMC11515778; DOI: 10.1186/s13195-024-01601-w;
     
  2. Kang M, Li C, Mahajan A, Spat-Lemus J, Durape S, Chen J, Gurnani AS, Devine S, Auerbach SH, Ang TFA, Sherva R, Qiu WQ, Lunetta KL, Au R, Farrer LA, Mez J. Subjective Cognitive Decline Plus and Longitudinal Assessment and Risk for Cognitive Impairment. JAMA Psychiatry. 2024 Oct 01; 81(10):993-1002.View Related Profiles. PMID: 38959008; PMCID: PMC11223054; DOI: 10.1001/jamapsychiatry.2024.1678;
     
  3. Gunn S, Wang X, Posner DC, Cho K, Huffman JE, Gaziano M, Wilson PW, Sun YV, Peloso G, Lunetta KL. Comparison of methods for building polygenic scores for diverse populations. HGG Adv. 2024 Sep 25; 6(1):100355.View Related Profiles. PMID: 39323095; PMCID: PMC11532986; DOI: 10.1016/j.xhgg.2024.100355;
     
  4. Chen J, Ragab AAY, Doyle MF, Alosco ML, Fang Y, Mez J, Satizabal CL, Qiu WQ, Murabito JM, Lunetta KL. Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort. Alzheimers Dement. 2024 Nov; 20(11):7465-7478.View Related Profiles. PMID: 39282876; PMCID: PMC11567832; DOI: 10.1002/alz.14147;
     
  5. Jurgens SJ, Wang X, Choi SH, Weng LC, Koyama S, Pirruccello JP, Nguyen T, Smadbeck P, Jang D, Chaffin M, Walsh R, Roselli C, Elliott AL, Wijdeveld LFJM, Biddinger KJ, Kany S, Rämö JT, Natarajan P, Aragam KG, Flannick J, Burtt NP, Bezzina CR, Lubitz SA, Lunetta KL, Ellinor PT. Rare coding variant analysis for human diseases across biobanks and ancestries. Nat Genet. 2024 Sep; 56(9):1811-1820. PMID: 39210047
     
  6. Kentistou KA, Kaisinger LR, Stankovic S, Vaudel M, Mendes de Oliveira E, Messina A, Walters RG, Liu X, Busch AS, Helgason H, Thompson DJ, Santoni F, Petricek KM, Zouaghi Y, Huang-Doran I, Gudbjartsson DF, Bratland E, Lin K, Gardner EJ, Zhao Y, Jia RY, Terao C, Riggan MJ, Bolla MK, Yazdanpanah M, Yazdanpanah N, Bradfield JP, Broer L, Campbell A, Chasman DI, Cousminer DL, Franceschini N, Franke LH, Girotto G, He C, Järvelin MR, Joshi PK, Kamatani Y, Karlsson R, Luan J, Lunetta KL, Mägi R, Mangino M, Medland SE, Meisinger C, Noordam R, Nutile T, Concas MP, Polašek O, Porcu E, Ring SM, Sala C, Smith AV, Tanaka T, van der Most PJ, Vitart V, Wang CA, Willemsen G, Zygmunt M, Ahearn TU, Andrulis IL, Anton-Culver H, Antoniou AC, Auer PL, Barnes CLK, Beckmann MW, Berrington de Gonzalez A, Bogdanova NV, Bojesen SE, Brenner H, Buring JE, Canzian F, Chang-Claude J, Couch FJ, Cox A, Crisponi L, Czene K, Daly MB, Demerath EW, Dennis J, Devilee P, De Vivo I, Dörk T, Dunning AM, Dwek M, Eriksson JG, Fasching PA, Fernandez-Rhodes L, Ferreli L, Fletcher O, Gago-Dominguez M, García-Closas M, García-Sáenz JA, González-Neira A, Grallert H, Guénel P, Haiman CA, Hall P, Hamann U, Hakonarson H, Hart RJ, Hickey M, Hooning MJ, Hoppe R, Hopper JL, Hottenga JJ, Hu FB, Huebner H, Hunter DJ, Jernström H, John EM, Karasik D, Khusnutdinova EK, Kristensen VN, Lacey JV, Lambrechts D, Launer LJ, Lind PA, Lindblom A, Magnusson PKE, Mannermaa A, McCarthy MI, Meitinger T, Menni C, Michailidou K, Millwood IY, Milne RL, Montgomery GW, Nevanlinna H, Nolte IM, Nyholt DR, Obi N, O'Brien KM, Offit K, Oldehinkel AJ, Ostrowski SR, Palotie A, Pedersen OB, Peters A, Pianigiani G, Plaseska-Karanfilska D, Pouta A, Pozarickij A, Radice P, Rennert G, Rosendaal FR, Ruggiero D, Saloustros E, Sandler DP, Schipf S, Schmidt CO, Schmidt MK, Small K, Spedicati B, Stampfer M, Stone J, Tamimi RM, Teras LR, Tikkanen E, Turman C, Vachon CM, Wang Q, Winqvist R, Wolk A, Zemel BS, Zheng W, van Dijk KW, Alizadeh BZ, Bandinelli S, Boerwinkle E, Boomsma DI, Ciullo M, Chenevix-Trench G, Cucca F, Esko T, Gieger C, Grant SFA, Gudnason V, Hayward C, Kolcic I, Kraft P, Lawlor DA, Martin NG, Nøhr EA, Pedersen NL, Pennell CE, Ridker PM, Robino A, Snieder H, Sovio U, Spector TD, Stöckl D, Sudlow C, Timpson NJ, Toniolo D, Uitterlinden A, Ulivi S, Völzke H, Wareham NJ, Widen E, Wilson JF, Pharoah PDP, Li L, Easton DF, Njølstad PR, Sulem P, Murabito JM, Murray A, Manousaki D, Juul A, Erikstrup C, Stefansson K, Horikoshi M, Chen Z, Farooqi IS, Pitteloud N, Johansson S, Day FR, Perry JRB, Ong KK. Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum. Nat Genet. 2024 Aug; 56(8):1763-1764.View Related Profiles. PMID: 38982295; PMCID: PMC11319190; DOI: 10.1038/s41588-024-01857-w;
     
  7. Kentistou KA, Kaisinger LR, Stankovic S, Vaudel M, Mendes de Oliveira E, Messina A, Walters RG, Liu X, Busch AS, Helgason H, Thompson DJ, Santoni F, Petricek KM, Zouaghi Y, Huang-Doran I, Gudbjartsson DF, Bratland E, Lin K, Gardner EJ, Zhao Y, Jia RY, Terao C, Riggan MJ, Bolla MK, Yazdanpanah M, Yazdanpanah N, Bradfield JP, Broer L, Campbell A, Chasman DI, Cousminer DL, Franceschini N, Franke LH, Girotto G, He C, Järvelin MR, Joshi PK, Kamatani Y, Karlsson R, Luan J, Lunetta KL, Mägi R, Mangino M, Medland SE, Meisinger C, Noordam R, Nutile T, Concas MP, Polašek O, Porcu E, Ring SM, Sala C, Smith AV, Tanaka T, van der Most PJ, Vitart V, Wang CA, Willemsen G, Zygmunt M, Ahearn TU, Andrulis IL, Anton-Culver H, Antoniou AC, Auer PL, Barnes CLK, Beckmann MW, Berrington de Gonzalez A, Bogdanova NV, Bojesen SE, Brenner H, Buring JE, Canzian F, Chang-Claude J, Couch FJ, Cox A, Crisponi L, Czene K, Daly MB, Demerath EW, Dennis J, Devilee P, De Vivo I, Dörk T, Dunning AM, Dwek M, Eriksson JG, Fasching PA, Fernandez-Rhodes L, Ferreli L, Fletcher O, Gago-Dominguez M, García-Closas M, García-Sáenz JA, González-Neira A, Grallert H, Guénel P, Haiman CA, Hall P, Hamann U, Hakonarson H, Hart RJ, Hickey M, Hooning MJ, Hoppe R, Hopper JL, Hottenga JJ, Hu FB, Huebner H, Hunter DJ, Jernström H, John EM, Karasik D, Khusnutdinova EK, Kristensen VN, Lacey JV, Lambrechts D, Launer LJ, Lind PA, Lindblom A, Magnusson PKE, Mannermaa A, McCarthy MI, Meitinger T, Menni C, Michailidou K, Millwood IY, Milne RL, Montgomery GW, Nevanlinna H, Nolte IM, Nyholt DR, Obi N, O'Brien KM, Offit K, Oldehinkel AJ, Ostrowski SR, Palotie A, Pedersen OB, Peters A, Pianigiani G, Plaseska-Karanfilska D, Pouta A, Pozarickij A, Radice P, Rennert G, Rosendaal FR, Ruggiero D, Saloustros E, Sandler DP, Schipf S, Schmidt CO, Schmidt MK, Small K, Spedicati B, Stampfer M, Stone J, Tamimi RM, Teras LR, Tikkanen E, Turman C, Vachon CM, Wang Q, Winqvist R, Wolk A, Zemel BS, Zheng W, van Dijk KW, Alizadeh BZ, Bandinelli S, Boerwinkle E, Boomsma DI, Ciullo M, Chenevix-Trench G, Cucca F, Esko T, Gieger C, Grant SFA, Gudnason V, Hayward C, Kolcic I, Kraft P, Lawlor DA, Martin NG, Nøhr EA, Pedersen NL, Pennell CE, Ridker PM, Robino A, Snieder H, Sovio U, Spector TD, Stöckl D, Sudlow C, Timpson NJ, Toniolo D, Uitterlinden A, Ulivi S, Völzke H, Wareham NJ, Widen E, Wilson JF, Pharoah PDP, Li L, Easton DF, Njølstad PR, Sulem P, Murabito JM, Murray A, Manousaki D, Juul A, Erikstrup C, Stefansson K, Horikoshi M, Chen Z, Farooqi IS, Pitteloud N, Johansson S, Day FR, Perry JRB, Ong KK. Understanding the genetic complexity of puberty timing across the allele frequency spectrum. Nat Genet. 2024 Jul; 56(7):1397-1411.View Related Profiles. PMID: 38951643; PMCID: PMC11250262; DOI: 10.1038/s41588-024-01798-4;
     
  8. Ragab AAY, Doyle MF, Chen J, Fang Y, Lunetta KL, Murabito JM. Immune cell phenotypes and mortality in the Framingham Heart Study. Immun Ageing. 2024 Jun 12; 21(1):37.View Related Profiles. PMID: 38867269; PMCID: PMC11167945; DOI: 10.1186/s12979-024-00431-6;
     
  9. Pirruccello JP, Di Achille P, Choi SH, Rämö JT, Khurshid S, Nekoui M, Jurgens SJ, Nauffal V, Kany S, Ng K, Friedman SF, Batra P, Lunetta KL, Palotie A, Philippakis AA, Ho JE, Lubitz SA, Ellinor PT. Deep learning of left atrial structure and function provides link to atrial fibrillation risk. Nat Commun. 2024 May 21; 15(1):4304. PMID: 38773065; PMCID: PMC11109224; DOI: 10.1038/s41467-024-48229-w;
     
  10. Gunn S, Lunetta KL. Correlation-based tests for the formal comparison of polygenic scores in multiple populations. PLoS Genet. 2024 Apr; 20(4):e1011249. PMID: 38669290; PMCID: PMC11078427; DOI: 10.1371/journal.pgen.1011249;
     
Showing 10 of 324 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 323 publications over 32 distinct years, with a maximum of 27 publications in 2017

YearPublications
19911
19922
19941
19953
19963
19972
19982
19993
20005
20015
20021
20041
20054
20062
20079
20089
200911
201012
201116
201214
201317
201418
201517
201622
201727
201816
201919
20209
202119
202218
202319
202416

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Statistical genetics
Genetic Epidemiology
Healthy Aging
Atrial Fibrillation
Alzheimer's Disease
Contact for Mentoring:

801 Massachusetts Ave Crosstown Center
Boston MA 02118
Google Map


Lunetta's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department