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Last Name

Mayetri Gupta, PhD

TitleAdjunct Associate Professor
InstitutionBoston University School of Public Health
DepartmentBiostatistics
Address801 Massachusetts Ave Crosstown Center
Boston MA 02118
Phone(617) 638-5172
 Research Expertise & Professional Interests
Dr. Gupta's research focus is at the interface of Statistics and Computational Biology, addressing high-dimensional and missing data problems in genomics and bioinformatics, especially relating to gene regulation. Her methodological work includes the development of several novel statistical methods for the discovery of transcription factor binding sites from DNA sequence in a variety of genomes, ranging from bacteria to human.She has been extensively involved in the development of Bayesian methodologies for the discovery of gene regulatory networks combining multiple genomic data types, and discovery and analysis of chromatin features from high throughput data from genome tiling arrays. More recently, she has been involved in developing Bayesian methods for analysis of data from genome-wide association studies, and next generation sequencing data. Her other statistical research interests include Bayesian model and variable selection, Bayesian methods for clustering and classification and inference in hidden Markov and other latent class models. For more information about Dr.Gupta's work, please visit http://people.bu.edu/gupta/. Dr. Gupta also serves as a Bioinformatics mentor for the Biostatistics Training Grant in the department of Biostatistics.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Moser CB, Gupta M, Archer BN, White LF. The impact of prior information on estimates of disease transmissibility using Bayesian tools. PLoS One. 2015; 10(3):e0118762. PMID: 25793993.
    View in: PubMed
  2. Bis JC, DeStefano A, Liu X, Brody JA, Choi SH, Verhaaren BF, Debette S, Ikram MA, Shahar E, Butler KR, Gottesman RF, Muzny D, Kovar CL, Psaty BM, Hofman A, Lumley T, Gupta M, Wolf PA, van Duijn C, Gibbs RA, Mosley TH, Longstreth WT, Boerwinkle E, Seshadri S, Fornage M. Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium. PLoS One. 2014; 9(6):e99798. PMID: 24959832.
    View in: PubMed
  3. Lin H, Wang M, Brody JA, Bis JC, Dupuis J, Lumley T, McKnight B, Rice KM, Sitlani CM, Reid JG, Bressler J, Liu X, Davis BC, Johnson AD, O'Donnell CJ, Kovar CL, Dinh H, Wu Y, Newsham I, Chen H, Broka A, DeStefano AL, Gupta M, Lunetta KL, Liu CT, White CC, Xing C, Zhou Y, Benjamin EJ, Schnabel RB, Heckbert SR, Psaty BM, Muzny DM, Cupples LA, Morrison AC, Boerwinkle E. Strategies to design and analyze targeted sequencing data: cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet. 2014 Jun; 7(3):335-43. PMID: 24951659.
    View in: PubMed
  4. Lin H, Sinner MF, Brody JA, Arking DE, Lunetta KL, Rienstra M, Lubitz SA, Magnani JW, Sotoodehnia N, McKnight B, McManus DD, Boerwinkle E, Psaty BM, Rotter JI, Bis JC, Gibbs RA, Muzny D, Kovar CL, Morrison AC, Gupta M, Folsom AR, Kääb S, Heckbert SR, Alonso A, Ellinor PT, Benjamin EJ. Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study. Heart Rhythm. 2014 Mar; 11(3):452-7. PMID: 24239840.
    View in: PubMed
  5. Gelfond JA, Ibrahim JG, Gupta M, Chen MH, Cody JD. Differential expression analysis with global network adjustment. BMC Bioinformatics. 2013; 14:258. PMID: 23968143.
    View in: PubMed
  6. Hendricks AE, Dupuis J, Gupta M, Logue MW, Lunetta KL. A comparison of gene region simulation methods. PLoS One. 2012; 7(7):e40925. PMID: 22815869.
    View in: PubMed
  7. Moser C, Gupta M. A generalized hidden Markov model for determining sequence-based predictors of nucleosome positioning. Stat Appl Genet Mol Biol. 2012; 11(2). PMID: 22499697.
    View in: PubMed
  8. Gupta M, Cheung CL, Hsu YH, Demissie S, Cupples LA, Kiel DP, Karasik D. Identification of homogeneous genetic architecture of multiple genetically correlated traits by block clustering of genome-wide associations. J Bone Miner Res. 2011 Jun; 26(6):1261-71. PMID: 21611967.
    View in: PubMed
  9. Mitra R, Gupta M. A continuous-index Bayesian hidden Markov model for prediction of nucleosome positioning in genomic DNA. Biostatistics. 2011 Jul; 12(3):462-77. PMID: 21193724.
    View in: PubMed
  10. Meltzer M, Long K, Nie Y, Gupta M, Yang J, Montano M. The RNA editor gene ADAR1 is induced in myoblasts by inflammatory ligands and buffers stress response. Clin Transl Sci. 2010 Jun; 3(3):73-80. PMID: 20590675.
    View in: PubMed
  11. Gelfond JA, Gupta M, Ibrahim JG. A Bayesian hidden Markov model for motif discovery through joint modeling of genomic sequence and ChIP-chip data. Biometrics. 2009 Dec; 65(4):1087-95. PMID: 19210737.
    View in: PubMed
  12. Cheng F, Hartmann S, Gupta M, Ibrahim JG, Vision TJ. A hierarchical model for incomplete alignments in phylogenetic inference. Bioinformatics. 2009 Mar 1; 25(5):592-8. PMID: 19147663.
    View in: PubMed
  13. Gupta M. Model selection and sensitivity analysis for sequence pattern models. Inst Math Stat Collect. 2009 Jan 01; 1:390-407. PMID: 20563269.
    View in: PubMed
  14. Gupta M, Ibrahim JG. An Information Matrix Prior for Bayesian Analysis in Generalized Linear Models with High Dimensional Data. Stat Sin. 2009; 19(4):1641-1663. PMID: 20664718.
    View in: PubMed
  15. Jeong YC, Walker NJ, Burgin DE, Kissling G, Gupta M, Kupper L, Birnbaum LS, Swenberg JA. Accumulation of M1dG DNA adducts after chronic exposure to PCBs, but not from acute exposure to polychlorinated aromatic hydrocarbons. Free Radic Biol Med. 2008 Sep 1; 45(5):585-91. PMID: 18534201.
    View in: PubMed
  16. Gupta M. Generalized hierarchical markov models for the discovery of length-constrained sequence features from genome tiling arrays. Biometrics. 2007 Sep; 63(3):797-805. PMID: 17825011.
    View in: PubMed
  17. Gupta M, Qu P, Ibrahim JG. A temporal hidden Markov regression model for the analysis of gene regulatory networks. Biostatistics. 2007 Oct; 8(4):805-20. PMID: 17400597.
    View in: PubMed
  18. Maki A, Kono H, Gupta M, Asakawa M, Suzuki T, Matsuda M, Fujii H, Rusyn I. Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma. Ann Surg Oncol. 2007 Mar; 14(3):1182-90. PMID: 17195915.
    View in: PubMed
  19. Giresi PG, Gupta M, Lieb JD. Regulation of nucleosome stability as a mediator of chromatin function. Curr Opin Genet Dev. 2006 Apr; 16(2):171-6. PMID: 16503136.
    View in: PubMed
  20. Gupta M, Liu JS. De novo cis-regulatory module elicitation for eukaryotic genomes. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7079-84. PMID: 15883375.
    View in: PubMed
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