Orian S. Shirihai, MD, PhD
Adjunct Associate Professor
Boston University School of Medicine
Dept of Medicine
Gastroenterology

MD, Technion - Israel Institute of Technology
PhD, Technion - Israel Institute of Technology




Expertise includes: Mitochondial biology; Mitochondrial bioenergetics; Mitochondrial dynamics; Imaging of mitochondrial architecture and function; Microscopy.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


Boston Medical Center





Role of IAPP in Islet Dysfunction in Diabetes
04/01/2015 - 01/31/2020 (PI)
Univ of California, Los Angeles NIH-NIDDK

Mitochondrial Dynamics in Beta Cell Function & Dysfunction
08/01/2012 - 07/31/2017 (PI)
NIH-NIDDK
5R01DK074778-10

Mitochondrial Dynamics in Beta Cell Function & Dysfunction
08/01/2012 - 07/31/2017 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01DK074778-10

Metabolic Signal Transduction in Adipocytes 2
02/01/2014 - 01/31/2017 (PI)
NIH-NIDDK
5R01DK056690-14

Mitochondrial regulation of energy efficiency
04/01/2014 - 04/02/2016 (PI)
NIH-NIDDK
1R01DK099618-01A1

Mitochondrial regulation of energy efficiency
04/01/2014 - 04/02/2016 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01DK099618-03

Testing Mitochondrial Bioenergetics
09/05/2012 - 03/31/2016 (PI)
BioEnergetics, LLC

Metabolic Signal Transduction in Adipocytes
04/01/2011 - 01/31/2016 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01 DK056690-13

Binding of Annexin Proteins to Cancer Cells
08/01/2013 - 10/01/2015 (PI)
Advanced Proteome Therapeutics, Inc.

Metabolic Regulation of Insulin Secretion
09/15/2010 - 12/30/2014 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01 DK035914-28

Showing 10 of 20 results. Show All Results


Yr Title Project-Sub Proj Pubs
2019 A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles 1R21AG060456-01A1
2019 R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD 1R21AG063373-01
2019 OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA 1R01CA232056-01A1
2018 Mitochondrial regulation of energy efficiency 5R01DK099618-05 12
2017 Mitochondrial regulation of energy efficiency 7R01DK099618-04 12
2016 Mitochondrial regulation of energy efficiency 5R01DK099618-03 12
2015 Mitochondrial regulation of energy efficiency 5R01DK099618-02 12
2015 Mitochondrial dynamics in beta cell function and dysfunction 5R01DK074778-10 52
2015 Metabolic Signal Transduction in Adipocytes 5R01DK056690-15 63
2014 Mitochondrial regulation of energy efficiency 1R01DK099618-01A1 12
Showing 10 of 44 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Liesa M, Van der Bliek A, Shirihai OS. To Fis or not to Fuse? This is the question! EMBO J. 2019 Apr 15; 38(8). PMID: 30936092.
     
  2. Benador IY, Veliova M, Liesa M, Shirihai OS. Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization. Cell Metab. 2019 Apr 02; 29(4):827-835.View Related Profiles. PMID: 30905670.
     
  3. Winn NC, Acin-Perez R, Woodford ML, Hansen SA, Haney MM, Ayedun LA, Rector RS, Vieira-Potter VJ, Shirihai OS, Sacks HS, Kanaley JA, Padilla J. A Thermogenic-Like Brown Adipose Tissue Phenotype is Dispensable for Enhanced Glucose Tolerance in Female Mice. Diabetes. 2019 Mar 12. PMID: 30862679.
     
  4. Salazar C, Elorza AA, Cofre G, Ruiz-Hincapie P, Shirihai O, Ruiz LM. The OXPHOS supercomplex assembly factor HIG2A responds to changes in energetic metabolism and cell cycle. J Cell Physiol. 2019 Feb 18. PMID: 30779122.
     
  5. Zeng J, Shirihai OS, Grinstaff MW. Degradable Nanoparticles Restore Lysosomal pH and Autophagic Flux in Lipotoxic Pancreatic Beta Cells. Adv Healthc Mater. 2019 Jan 30; e1801511.View Related Profiles. PMID: 30698920.
     
  6. Assali EA, Shlomo D, Zeng J, Taddeo EP, Trudeau KM, Erion KA, Colby AH, Grinstaff MW, Liesa M, Las G, Shirihai OS. Nanoparticle-mediated lysosomal reacidification restores mitochondrial turnover and function in ß cells under lipotoxicity. FASEB J. 2019 Mar; 33(3):4154-4165.View Related Profiles. PMID: 30550357.
     
  7. Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL. The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle. Mol Metab. 2019 Mar; 21:51-67. PMID: 30591411.
     
  8. Taddeo EP, Stiles L, Sereda S, Ritou E, Wolf DM, Abdullah M, Swanson Z, Wilhelm J, Bellin M, McDonald P, Caradonna K, Neilson A, Liesa M, Shirihai OS. Individual islet respirometry reveals functional diversity within the islet population of mice and human donors. Mol Metab. 2018 Oct; 16:150-159. PMID: 30098928.
     
  9. Waters LR, Ahsan FM, Wolf DM, Shirihai O, Teitell MA. Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling. iScience. 2018 Jul 27; 5:99-109. PMID: 30240649.
     
  10. Xu S, Catapang A, Braas D, Stiles L, Doh HM, Lee JT, Graeber TG, Damoiseaux R, Shirihai O, Herschman HR. A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. Cancer Metab. 2018; 6:7. PMID: 29988332.
     
Showing 10 of 117 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 117 publications over 21 distinct years, with a maximum of 15 publications in 2012

YearPublications
19961
19983
20001
20011
20021
20044
20051
20062
20074
20084
200910
20105
20119
201215
20137
20147
201511
201611
20176
20189
20195
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

autopagy
fission
fusion
Mitochondria
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Google Map


Shirihai's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department