Orian S. Shirihai, MD, PhD
Adjunct Associate Professor
Boston University School of Medicine
Dept of Medicine
Gastroenterology

MD, Technion - Israel Institute of Technology
PhD, Technion - Israel Institute of Technology




Expertise includes: Mitochondial biology; Mitochondrial bioenergetics; Mitochondrial dynamics; Imaging of mitochondrial architecture and function; Microscopy.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


Boston Medical Center





Role of IAPP in Islet Dysfunction in Diabetes
04/01/2015 - 01/31/2020 (PI)
Univ of California, Los Angeles NIH-NIDDK

Mitochondrial Dynamics in Beta Cell Function & Dysfunction
08/01/2012 - 07/31/2017 (PI)
NIH-NIDDK
5R01DK074778-10

Mitochondrial Dynamics in Beta Cell Function & Dysfunction
08/01/2012 - 07/31/2017 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01DK074778-10

Metabolic Signal Transduction in Adipocytes 2
02/01/2014 - 01/31/2017 (PI)
NIH-NIDDK
5R01DK056690-14

Mitochondrial regulation of energy efficiency
04/01/2014 - 04/02/2016 (PI)
NIH-NIDDK
1R01DK099618-01A1

Mitochondrial regulation of energy efficiency
04/01/2014 - 04/02/2016 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01DK099618-03

Testing Mitochondrial Bioenergetics
09/05/2012 - 03/31/2016 (PI)
BioEnergetics, LLC

Metabolic Signal Transduction in Adipocytes
04/01/2011 - 01/31/2016 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01 DK056690-13

Binding of Annexin Proteins to Cancer Cells
08/01/2013 - 10/01/2015 (PI)
Advanced Proteome Therapeutics, Inc.

Metabolic Regulation of Insulin Secretion
09/15/2010 - 12/30/2014 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01 DK035914-28

Showing 10 of 20 results. Show All Results

Title


Yr Title Project-Sub Proj Pubs
2020 MITOCHONDRIAL RESPIROMETRY IN FROZEN BIOLOGICAL SAMPLES 1R41ES031043-01A1
2020 A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles 5R21AG060456-02
2020 A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles 5R21AG060456-02
2020 R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD 5R21AG063373-02
2020 R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD 5R21AG063373-02
2020 OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA 5R01CA232056-02
2019 A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles 1R21AG060456-01A1
2019 R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD 1R21AG063373-01
2019 OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA 1R01CA232056-01A1
2018 Mitochondrial regulation of energy efficiency 5R01DK099618-05 14
Showing 10 of 50 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Acín-Pérez R, Iborra S, Martí-Mateos Y, Cook ECL, Conde-Garrosa R, Petcherski A, Muñoz MDM, Martínez de Mena R, Krishnan KC, Jiménez C, Bolaños JP, Laakso M, Lusis AJ, Shirihai OS, Sancho D, Enríquez JA. Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity. Nat Metab. 2020 Sep; 2(9):974-988. PMID: 32943786
     
  2. Yang J, Guo Y, Henning SM, Chan B, Long J, Zhong J, Acin-Perez R, Petcherski A, Shirihai O, Heber D, Li Z. Ellagic Acid and Its Microbial Metabolite Urolithin A Alleviate Diet-Induced Insulin Resistance in Mice. Mol Nutr Food Res. 2020 Aug 11; e2000091. PMID: 32783299
     
  3. Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AJ, Hevener AL. Estrogen receptor a controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Sci Transl Med. 2020 Aug 05; 12(555).View Related Profiles. PMID: 32759275
     
  4. Assali EA, Jones AE, Veliova M, Acín-Pérez R, Taha M, Miller N, Shum M, Oliveira MF, Las G, Liesa M, Sekler I, Shirihai OS. NCLX prevents cell death during adrenergic activation of the brown adipose tissue. Nat Commun. 2020 07 03; 11(1):3347.View Related Profiles. PMID: 32620768
     
  5. Momcilovic M, Shirihai O, Murphy MP, Koehler CM, Sadeghi S, Shackelford DB. Reply to: In vivo quantification of mitochondrial membrane potential. Nature. 2020 Jul; 583(7815):E19-E20. PMID: 32641810
     
  6. Segawa M, Wolf DM, Hultgren NW, Williams DS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria. Life Sci Alliance. 2020 Jul; 3(7).View Related Profiles. PMID: 32499316
     
  7. Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS. A novel approach to measure mitochondrial respiration in frozen biological samples. EMBO J. 2020 Jul 01; 39(13):e104073.View Related Profiles. PMID: 32432379
     
  8. Veliova M, Petcherski A, Liesa M, Shirihai OS. The biology of lipid droplet-bound mitochondria. Semin Cell Dev Biol. 2020 May 20. PMID: 32446655
     
  9. Bradley MC, Yang K, Fernández-Del-Río L, Ngo J, Ayer A, Tsui HS, Novales NA, Stocker R, Shirihai OS, Barros MH, Clarke CF. COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10. J Biol Chem. 2020 May 01; 295(18):6023-6042. PMID: 32205446
     
  10. Wolf DM, Segawa M, Shirihai OS, Liesa M. Method for live-cell super-resolution imaging of mitochondrial cristae and quantification of submitochondrial membrane potentials. Methods Cell Biol. 2020; 155:545-555.View Related Profiles. PMID: 32183976
     
Showing 10 of 139 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 139 publications over 22 distinct years, with a maximum of 15 publications in 2012

YearPublications
19961
19983
20001
20011
20021
20044
20051
20062
20074
20084
200910
20105
20119
201215
20137
20147
201511
201611
20176
20189
201913
202014

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

autopagy
fission
fusion
Mitochondria
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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