Orian S. Shirihai, MD, PhD
Adjunct Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Dept of Medicine
Gastroenterology

MD, Technion - Israel Institute of Technology
PhD, Technion - Israel Institute of Technology



My laboratory is studying mitochondria in disease models including metabolic and cardiovascular. In the past ten years the lab has focused on the study of the interaction between mitochondria through fusion and fission events and the role of mitochondrial architecture in bioenergetics. The lab has established an array of assays for the study of islet mitochondrial bioenergetic functions. The lab is known for its development of key imaging approaches to quantify mitochondrial dynamics, motility and membrane potential. Using these methodologies to study mitochondrial dynamics we described the life cycle of the mitochondria, and the role of continuous fusion and fission dynamics in the maintenance of bioenergetic capacity and efficiency. The lab played a pivotal role in the development of cutting edge technology for high throughput respirometry in collaboration with Seahorse Bioscience. I am the founder of the mtARC (Mitochondria-Affinity Research Collaborative) which provides guidance in the mitochondrial science to the members of the Boston scientific community. The lab has trained over 10 post doctoral fellows, of which three have been recruited as faculty in academic institutions, and two are founders of new biotech companies.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences


Boston Medical Center





Role of IAPP in Islet Dysfunction in Diabetes
04/01/2015 - 01/31/2020 (PI)
Univ of California, Los Angeles NIH-NIDDK

Mitochondrial Dynamics in Beta Cell Function & Dysfunction
08/01/2012 - 07/31/2017 (PI)
NIH-NIDDK
5R01DK074778-10

Mitochondrial Dynamics in Beta Cell Function & Dysfunction
08/01/2012 - 07/31/2017 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01DK074778-10

Metabolic Signal Transduction in Adipocytes 2
02/01/2014 - 01/31/2017 (PI)
NIH-NIDDK
5R01DK056690-14

Mitochondrial regulation of energy efficiency
04/01/2014 - 04/02/2016 (PI)
NIH-NIDDK
1R01DK099618-01A1

Mitochondrial regulation of energy efficiency
04/01/2014 - 04/02/2016 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01DK099618-03

Testing Mitochondrial Bioenergetics
09/05/2012 - 03/31/2016 (PI)
BioEnergetics, LLC

Metabolic Signal Transduction in Adipocytes
04/01/2011 - 01/31/2016 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01 DK056690-13

Binding of Annexin Proteins to Cancer Cells
08/01/2013 - 10/01/2015 (PI)
Advanced Proteome Therapeutics, Inc.

Metabolic Regulation of Insulin Secretion
09/15/2010 - 12/30/2014 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01 DK035914-28

Showing 10 of 20 results. Show All Results

Title


Yr Title Project-Sub Proj Pubs
2022 Role of the heme-related mitochondrial antioxidant ABCB10 in alcoholic liver disease 5R01AA026914-04
2022 OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADINGFOR TREATING MESOTHELIOMA 5R01CA232056-04
2021 MITOCHONDRIAL RESPIROMETRY IN FROZEN BIOLOGICAL SAMPLES 3R41ES031043-01A1S1
2021 OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA 5R01CA232056-03
2020 MITOCHONDRIAL RESPIROMETRY IN FROZEN BIOLOGICAL SAMPLES 1R41ES031043-01A1
2020 A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles 5R21AG060456-02
2020 R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD 5R21AG063373-02
2020 OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA 5R01CA232056-02
2019 A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles 1R21AG060456-01A1
2019 R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD 1R21AG063373-01
Showing 10 of 51 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Desai M, Stiles L, Torsoni AS, Torsoni MA, Shirihai OS, Ross MG. TNFa-Induced Oxidative Stress and Mitochondrial Dysfunction Alter Hypothalamic Neurogenesis and Promote Appetite Versus Satiety Neuropeptide Expression in Mice. Brain Sci. 2022 Jul 09; 12(7). PMID: 35884707; PMCID: PMC9316209; DOI: 10.3390/brainsci12070900;
     
  2. Petcherski A, Sharma M, Daskou M, Satta S, Vasilopoulos H, Hugo C, Ritou E, Dillon BJ, Fung E, Garcia G, Scafoglio C, Purkayastha A, Gomperts BN, Fishbein GA, Arumugaswami V, Liesa M, Shirihai OS, Kelesidis T. Mitoquinone mesylate targets SARS-CoV-2 and associated lung inflammation through host pathways. bioRxiv. 2022 Feb 24. PMID: 35233569; PMCID: PMC8887067; DOI: 10.1101/2022.02.22.481100;
     
  3. Kelesidis T, Madhav S, Petcherski A, Cristelle H, O'Connor E, Hultgren NW, Ritou E, Williams DS, Shirihai OS, Reddy ST. The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells. Virulence. 2021 12; 12(1):2214-2227. PMID: 34494942; PMCID: PMC8437485; DOI: 10.1080/21505594.2021.1964329;
     
  4. Shum M, Segawa M, Gharakhanian R, Viñuela A, Wortham M, Baghdasarian S, Wolf DM, Sereda SB, Nocito L, Stiles L, Zhou Z, Gutierrez V, Sander M, Shirihai OS, Liesa M. Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance. Mol Metab. 2022 01; 55:101403.View Related Profiles. PMID: 34823065; PMCID: PMC8689243; DOI: 10.1016/j.molmet.2021.101403;
     
  5. Shen N, Korm S, Karantanos T, Li D, Zhang X, Ritou E, Xu H, Lam A, English J, Zong WX, Liu CT, Shirihai O, Feng H. DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer. Commun Biol. 2021 11 16; 4(1):1289.View Related Profiles. PMID: 34785772; PMCID: PMC8595664; DOI: 10.1038/s42003-021-02805-8;
     
  6. Brownstein AJ, Veliova M, Acin-Perez R, Liesa M, Shirihai OS. ATP-consuming futile cycles as energy dissipating mechanisms to counteract obesity. Rev Endocr Metab Disord. 2022 02; 23(1):121-131. PMID: 34741717; PMCID: PMC8873062; DOI: 10.1007/s11154-021-09690-w;
     
  7. Ngo J, Osto C, Villalobos F, Shirihai OS. Mitochondrial Heterogeneity in Metabolic Diseases. Biology (Basel). 2021 Sep 17; 10(9). PMID: 34571805; PMCID: PMC8470264; DOI: 10.3390/biology10090927;
     
  8. Acin-Perez R, Benincá C, Shabane B, Shirihai OS, Stiles L. Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives. Life (Basel). 2021 Sep 10; 11(9). PMID: 34575097; PMCID: PMC8467772; DOI: 10.3390/life11090949;
     
  9. Alysandratos KD, Russo SJ, Petcherski A, Taddeo EP, Acín-Pérez R, Villacorta-Martin C, Jean JC, Mulugeta S, Rodriguez LR, Blum BC, Hekman RM, Hix OT, Minakin K, Vedaie M, Kook S, Tilston-Lunel AM, Varelas X, Wambach JA, Cole FS, Hamvas A, Young LR, Liesa M, Emili A, Guttentag SH, Shirihai OS, Beers MF, Kotton DN. Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell Rep. 2021 08 31; 36(9):109636.View Related Profiles. PMID: 34469722; PMCID: PMC8432578; DOI: 10.1016/j.celrep.2021.109636;
     
  10. Acín-Perez R, Petcherski A, Veliova M, Benador IY, Assali EA, Colleluori G, Cinti S, Brownstein AJ, Baghdasarian S, Livhits MJ, Yeh MW, Krishnan KC, Vergnes L, Winn NC, Padilla J, Liesa M, Sacks HS, Shirihai OS. Recruitment and remodeling of peridroplet mitochondria in human adipose tissue. Redox Biol. 2021 10; 46:102087.View Related Profiles. PMID: 34411987; PMCID: PMC8377484; DOI: 10.1016/j.redox.2021.102087;
     
Showing 10 of 159 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 159 publications over 24 distinct years, with a maximum of 22 publications in 2020

YearPublications
19961
19983
20001
20011
20021
20044
20051
20062
20074
20084
200910
20105
20119
201215
20137
20147
201511
201611
20176
20189
201913
202022
202110
20222

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

autopagy
fission
fusion
Mitochondria
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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