Orian S. Shirihai, MD, PhD
Adjunct Associate Professor
Boston University School of Medicine
Dept of Medicine
Gastroenterology

MD, Technion - Israel Institute of Technology
PhD, Technion - Israel Institute of Technology




Expertise includes: Mitochondial biology; Mitochondrial bioenergetics; Mitochondrial dynamics; Imaging of mitochondrial architecture and function; Microscopy.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences


Boston Medical Center





Role of IAPP in Islet Dysfunction in Diabetes
04/01/2015 - 01/31/2020 (PI)
Univ of California, Los Angeles NIH-NIDDK

Mitochondrial Dynamics in Beta Cell Function & Dysfunction
08/01/2012 - 07/31/2017 (PI)
NIH-NIDDK
5R01DK074778-10

Mitochondrial Dynamics in Beta Cell Function & Dysfunction
08/01/2012 - 07/31/2017 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01DK074778-10

Metabolic Signal Transduction in Adipocytes 2
02/01/2014 - 01/31/2017 (PI)
NIH-NIDDK
5R01DK056690-14

Mitochondrial regulation of energy efficiency
04/01/2014 - 04/02/2016 (PI)
NIH-NIDDK
1R01DK099618-01A1

Mitochondrial regulation of energy efficiency
04/01/2014 - 04/02/2016 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01DK099618-03

Testing Mitochondrial Bioenergetics
09/05/2012 - 03/31/2016 (PI)
BioEnergetics, LLC

Metabolic Signal Transduction in Adipocytes
04/01/2011 - 01/31/2016 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01 DK056690-13

Binding of Annexin Proteins to Cancer Cells
08/01/2013 - 10/01/2015 (PI)
Advanced Proteome Therapeutics, Inc.

Metabolic Regulation of Insulin Secretion
09/15/2010 - 12/30/2014 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01 DK035914-28

Showing 10 of 20 results. Show All Results

Title


Yr Title Project-Sub Proj Pubs
2021 MITOCHONDRIAL RESPIROMETRY IN FROZEN BIOLOGICAL SAMPLES 3R41ES031043-01A1S1
2021 OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA 5R01CA232056-03
2020 MITOCHONDRIAL RESPIROMETRY IN FROZEN BIOLOGICAL SAMPLES 1R41ES031043-01A1
2020 A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles 5R21AG060456-02
2020 A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles 5R21AG060456-02
2020 R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD 5R21AG063373-02
2020 R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD 5R21AG063373-02
2020 OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA 5R01CA232056-02
2019 A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles 1R21AG060456-01A1
2019 R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD 1R21AG063373-01
Showing 10 of 52 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Rai P, Janardhan KS, Meacham J, Madenspacher JH, Lin WC, Karmaus PWF, Martinez J, Li QZ, Yan M, Zeng J, Grinstaff MW, Shirihai OS, Taylor GA, Fessler MB. IRGM1 links mitochondrial quality control to autoimmunity. Nat Immunol. 2021 03; 22(3):312-321.View Related Profiles. PMID: 33510463; PMCID: PMC7906953; DOI: 10.1038/s41590-020-00859-0;
     
  2. Miller N, Wolf D, Alsabeeh N, Mahdaviani K, Segawa M, Liesa M, Shirihai OS. High-Throughput Image Analysis of Lipid-Droplet-Bound Mitochondria. Methods Mol Biol. 2021; 2276:285-303.View Related Profiles. PMID: 34060050
     
  3. Ngo J, Benador IY, Brownstein AJ, Vergnes L, Veliova M, Shum M, Acín-Pérez R, Reue K, Shirihai OS, Liesa M. Isolation and functional analysis of peridroplet mitochondria from murine brown adipose tissue. STAR Protoc. 2021 Mar 19; 2(1):100243.View Related Profiles. PMID: 33458705; PMCID: PMC7797917; DOI: 10.1016/j.xpro.2020.100243;
     
  4. Veliova M, Ferreira CM, Benador IY, Jones AE, Mahdaviani K, Brownstein AJ, Desousa BR, Acín-Pérez R, Petcherski A, Assali EA, Stiles L, Divakaruni AS, Prentki M, Corkey BE, Liesa M, Oliveira MF, Shirihai OS. Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling. EMBO Rep. 2020 12 03; 21(12):e49634.View Related Profiles. PMID: 33275313; PMCID: PMC7726774; DOI: 10.15252/embr.201949634;
     
  5. Shum M, Ngo J, Shirihai OS, Liesa M. Mitochondrial oxidative function in NAFLD: Friend or foe? Mol Metab. 2020 Dec 01; 101134. PMID: 33276146
     
  6. Osto C, Benador IY, Ngo J, Liesa M, Stiles L, Acin-Perez R, Shirihai OS. Measuring Mitochondrial Respiration in Previously Frozen Biological Samples. Curr Protoc Cell Biol. 2020 12; 89(1):e116.View Related Profiles. PMID: 33320426
     
  7. Zeng J, Shirihai OS, Grinstaff MW. Modulating lysosomal pH: a molecular and nanoscale materials design perspective. J Life Sci (Westlake Village). 2020 Dec; 2(4):25-37.View Related Profiles. PMID: 33403369; PMCID: PMC7781074; DOI: 10.36069/jols/20201204;
     
  8. Gonzalez-Ibanez AM, Ruiz LM, Jensen E, Echeverria CA, Romero V, Stiles L, Shirihai OS, Elorza AA. Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics. Front Cell Dev Biol. 2020; 8:592035. PMID: 33330472; PMCID: PMC7719720; DOI: 10.3389/fcell.2020.592035;
     
  9. Jones AE, Sheng L, Acevedo A, Veliova M, Shirihai OS, Stiles L, Divakaruni AS. Forces, fluxes, and fuels: tracking mitochondrial metabolism by integrating measurements of membrane potential, respiration, and metabolites. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C80-C91. PMID: 33147057; PMCID: PMC7846976; DOI: 10.1152/ajpcell.00235.2020;
     
  10. Acín-Pérez R, Iborra S, Martí-Mateos Y, Cook ECL, Conde-Garrosa R, Petcherski A, Muñoz MDM, Martínez de Mena R, Krishnan KC, Jiménez C, Bolaños JP, Laakso M, Lusis AJ, Shirihai OS, Sancho D, Enríquez JA. Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity. Nat Metab. 2020 09; 2(9):974-988. PMID: 32943786
     
Showing 10 of 149 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 149 publications over 23 distinct years, with a maximum of 22 publications in 2020

YearPublications
19961
19983
20001
20011
20021
20044
20051
20062
20074
20084
200910
20105
20119
201215
20137
20147
201511
201611
20176
20189
201913
202022
20212

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

autopagy
fission
fusion
Mitochondria
Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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