Esther Bullitt, PhD
Associate Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Brandeis University


Pronouns: she/her/hers



Structural studies of biological macromolecular assemblies are providing an understanding of cellular function. In our laboratory, we utilize electron microscopy and image reconstruction to investigate questions about microbial virulence.

Work in the lab currently focuses on bacterial adhesion pili (fimbriae), type III secretion system needles, and virus replication. These projects address basic medical research questions directed at understanding bacterial adhesion to human host tissue and viral replication. Our data support development of novel therapeutics targeting these important health issues including, for example, development of a vaccine against traveler’s diarrhea.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Exploiting the Salivary Arsenal to Inhibit Diarrheal Disease
02/22/2021 - 01/31/2023 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI156236-02

The multiple states of IpaB Shigella type lll secretion
06/02/2014 - 11/30/2018 (Subcontract PI)
University of Kansas NIH NIAID
5R01AI099489-06

Towards the Disruption of Viral RNA Replication
07/01/2012 - 06/30/2017 (PI)
NIH/National Institute of General Medical Sciences
5R01GM102474-04

Measurement of Bacteriophage Lengths using Transmission electron microscopy and image analysis
01/01/2012 - 12/31/2016 (PI)
Neurophage pharmaceuticals, Inc.


Towards the Disruption of Viral RNA Replication
07/01/2012 - 06/30/2016 (PI)
NIH/National Institute of General Medical Sciences
1R01GM102474-01

The multiple states of IpaB Shigella type III secretion
12/04/2012 - 06/01/2014 (Subcontract PI)
University of Oklahoma NIH NIAID
1R01AI099489-01A1



Title


Yr Title Project-Sub Proj Pubs
2022 Exploiting the Salivary Arsenal to Inhibit Diarrheal Disease 5R21AI156236-02
2021 Exploiting the Salivary Arsenal to Inhibit Diarrheal Disease 1R21AI156236-01
2021 Midwest Consortium for High Resolution Cryoelectron Microscopy 5U24GM116789-05 3
2020 CryoEM Data Collection Facility Consortium at NCM 5U24GM116787-05 6
2020 Midwest Consortium for High Resolution Cryoelectron Microscopy 5U24GM116789-04 3
2020 The Southeastern Consortium for Microscopy of MacroMolecular Machines 5U24GM116788-05 7
2019 CryoEM Data Collection Facility Consortium at NCM 5U24GM116787-04 6
2019 Midwest Consortium for High Resolution Cryoelectron Microscopy 5U24GM116789-03 3
2019 The Southeastern Consortium for Microscopy of MacroMolecular Machines 5U24GM116788-04 7
2019 Administrative Supplement: The Southeastern Consortium for Microscopy of MacroMolecular Machines 3U24GM116788-04S1 7
Showing 10 of 39 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Werder RB, Liu T, Abo KM, Lindstrom-Vautrin J, Villacorta-Martin C, Huang J, Hinds A, Boyer N, Bullitt E, Liesa M, Silverman EK, Kotton DN, Cho MH, Zhou X, Wilson AA. CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells. Sci Adv. 2022 Jul 15; 8(28):eabo6566.View Related Profiles. PMID: 35857525; PMCID: PMC9278866; DOI: 10.1126/sciadv.abo6566;
     
  2. Hume AJ, Heiden B, Olejnik J, Suder EL, Ross S, Scoon WA, Bullitt E, Ericsson M, White MR, Turcinovic J, Thao TTN, Hekman RM, Kaserman JE, Huang J, Alysandratos KD, Toth GE, Jakab F, Kotton DN, Wilson AA, Emili A, Thiel V, Connor JH, Kemenesi G, Cifuentes D, Mühlberger E. Correction: Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog. 2022 Jun; 18(6):e1010659.View Related Profiles. PMID: 35749346; PMCID: PMC9231773; DOI: 10.1371/journal.ppat.1010659;
     
  3. Dahlberg T, Baker JL, Bullitt E, Andersson M. Unveiling molecular interactions that stabilize bacterial adhesion pili. Biophys J. 2022 Jun 07; 121(11):2096-2106. PMID: 35491503; PMCID: PMC9247471; DOI: 10.1016/j.bpj.2022.04.036;
     
  4. Kenney DJ, O'Connell AK, Turcinovic J, Montanaro P, Hekman RM, Tamura T, Berneshawi AR, Cafiero TR, Al Abdullatif S, Blum B, Goldstein SI, Heller BL, Gertje HP, Bullitt E, Trachtenberg AJ, Chavez E, Nono ET, Morrison C, Tseng AE, Sheikh A, Kurnick S, Grosz K, Bosmann M, Ericsson M, Huber BR, Saeed M, Balazs AB, Francis KP, Klose A, Paragas N, Campbell JD, Connor JH, Emili A, Crossland NA, Ploss A, Douam F. Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection. Cell Rep. 2022 Apr 19; 39(3):110714.View Related Profiles. PMID: 35421379; PMCID: PMC8977517; DOI: 10.1016/j.celrep.2022.110714;
     
  5. Abo KM, Sainz de Aja J, Lindstrom-Vautrin J, Alysandratos KD, Richards A, Garcia-de-Alba C, Huang J, Hix OT, Werder RB, Bullitt E, Hinds A, Falconer I, Villacorta-Martin C, Jaenisch R, Kim CF, Kotton DN, Wilson AA. Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell-derived alveolar epithelium. JCI Insight. 2022 Mar 22; 7(6).View Related Profiles. PMID: 35315362; PMCID: PMC8986076; DOI: 10.1172/jci.insight.155589;
     
  6. Hume AJ, Heiden B, Olejnik J, Suder EL, Ross S, Scoon WA, Bullitt E, Ericsson M, White MR, Turcinovic J, Thao TTN, Hekman RM, Kaserman JE, Huang J, Alysandratos KD, Toth GE, Jakab F, Kotton DN, Wilson AA, Emili A, Thiel V, Connor JH, Kemenesi G, Cifuentes D, Mühlberger E. Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog. 2022 02; 18(2):e1010268.View Related Profiles. PMID: 35120176; PMCID: PMC8849519; DOI: 10.1371/journal.ppat.1010268;
     
  7. Gao Z, Zhang X, Zhang L, Wu S, Ma J, Wang F, Zhou Y, Dai X, Bullitt E, Du Y, Guo JT, Chang J. A yellow fever virus NS4B inhibitor not only suppresses viral replication, but also enhances the virus activation of RIG-I-like receptor-mediated innate immune response. PLoS Pathog. 2022 01; 18(1):e1010271. PMID: 35061864; PMCID: PMC8809586; DOI: 10.1371/journal.ppat.1010271;
     
  8. Wang R, Hume AJ, Beermann ML, Simone-Roach C, Lindstrom-Vautrin J, Le Suer J, Huang J, Olejnik J, Villacorta-Martin C, Bullitt E, Hinds A, Ghaedi M, Rollins S, Werder RB, Abo KM, Wilson AA, Mühlberger E, Kotton DN, Hawkins FJ. Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection. Am J Physiol Lung Cell Mol Physiol. 2022 03 01; 322(3):L462-L478.View Related Profiles. PMID: 35020534; PMCID: PMC8917936; DOI: 10.1152/ajplung.00397.2021;
     
  9. Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG. Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis. Hepatology. 2022 04; 75(4):968-982.View Related Profiles. PMID: 34662439; PMCID: PMC9299888; DOI: 10.1002/hep.32203;
     
  10. Baker JL, Dahlberg T, Bullitt E, Andersson M. Impact of an alpha helix and a cysteine-cysteine disulfide bond on the resistance of bacterial adhesion pili to stress. Proc Natl Acad Sci U S A. 2021 05 25; 118(21). PMID: 34011607; PMCID: PMC8166124; DOI: 10.1073/pnas.2023595118;
     
Showing 10 of 66 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 66 publications over 28 distinct years, with a maximum of 8 publications in 2022

YearPublications
19851
19861
19881
19921
19951
19962
19971
19982
20001
20022
20042
20062
20073
20082
20092
20102
20113
20123
20133
20141
20154
20161
20171
20183
20194
20205
20214
20228

2021 Microscopy Society of America: Past-President
2020 Microscopy Society of America: President
2019 Microscopy Society of America: President-elect
2018-pres International Union of Crystallography Journal: Associate Editor
Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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