Xiaoling Zhang | Profiles RNS

Xiaoling Zhang, MD, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Biomedical Genetics

MD, Hubei University of Chinese Medicine
PhD, Boston University
MS, State University of New York at Buffalo

Websites

	Zhang's Lab
	Department of Medicine
	Biomedical Genetics
	BU School of Public Health
	BUSM
	Pulmonomics Lab
	LinkedIn
	ResearchGate
	Google Scholar
	Computing & Data Sciences
	Bioinformatics

ORCID : 0000-0001-8237-1857

Dr. Xiaoling Zhang is an Associate Professor of Medicine in Biomedical Genetics at the Chobanian and Avedisian School of Medicine . She seeks to discover genetic risk factors of complex human diseases, and further to identify their underlying functional mechanisms. She received her doctorate in Bioinformatics from Boston University and her Master's degree in Computer Science from the State University of New York at Buffalo. After being trained in epidemiology genetics and genomics at the NIH-NHLBI Framingham Heart Study, she is actively pursuing the driving force of Alzheimer’s disease (AD), and its shared genetic structure and functional pathways with other diseases including cardiometabolic disorders and some type of cancers by integrating genome-wide DNA & RNA sequencing and a variety of functional genomic data.

Her primary research interests focus on: 1) develop methods for analyzing large-scale genetics and genomics data including microarray, genotype and next-generation sequencing data; 2) discover common, low-frequency and rare variants associated with complex diseases and their risk factors; 3) identify and prioritize putative causal genetic variants by integrative genomics study that involves combining biological information from a wide-range of data resources with eQTL analysis, pathway analysis and regulatory network analysis; and 4) translate the above computational findings to the molecular mechanisms underlying human genetic disorders by conducting experimental validation through collaborations.

Associate Professor
Boston University School of Public Health
Biostatistics

Associate Professor
Boston University
Computing & Data Sciences
Bioinformatics Program

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

tRNA modifications regulating mitochondrial function and the mitochondrial proteome in AD/ADRD
09/15/2025 - 06/30/2030 (Multi-PI)
PI: Xiaoling Zhang, MD, PhD
NIH/National Institute on Aging
1R01AG096052-01

tRNA Epitranscriptome and Translational Dysfunction in ADRD
09/15/2025 - 05/31/2030 (Multi-PI)
PI: Xiaoling Zhang, MD, PhD
NIH/National Institute on Aging
1R01AG095773-01

The role of N6-methyladenosine modified RNA in Alzheimer's disease
12/15/2022 - 11/30/2027 (Multi-PI)
PI: Xiaoling Zhang, MD, PhD
NIH/National Institute on Aging
5R01AG080810-04

DMS/NIGMS 1: Multilevel stochastic orthogonal subspace transformations for robust machine learning with applications to biomedical data and Alzheimer's disease subtyping
05/01/2024 - 04/30/2027 (Multi-PI)
PI: Xiaoling Zhang, MD, PhD
National Science Foundation
2347698

Circular RNAs and their interactions with RNA-binding proteins to modulate AD-related neuropathology
07/01/2021 - 06/30/2026 (Multi-PI)
PI: Xiaoling Zhang, MD, PhD
NIH/National Institute on Aging
5U01AG072577-05

Title

Precision Monitoring and Assessment in the Framingham Heart Study: Cognitive, MRI, Genetic and Biomarker Precursors of AD & Dementia
09/15/2020 - 08/31/2025 (Co-PI of Sub-Project / SP)
PI: Lindsay Farrer, PhD
Boston University
U19-AG068753

Yr	Title	Project-Sub Proj
2026	The role of N6-methyladenosine modified RNA in Alzheimer's disease	5R01AG080810-04
2025	tRNA modifications regulating mitochondrial function and the mitochondrial proteome in AD/ADRD	1R01AG096052-01
2025	FunGen-xQTL: Unraveling the genetic basis of molecular functions in Alzheimer's Disease	1R01AG086467-01A1
2025	The role of N6-methyladenosine modified RNA in Alzheimer's disease	5R01AG080810-03
2025	Circular RNAs and their interactions with RNA-binding proteins to modulate AD-related neuropathology	5U01AG072577-05
2024	The role of N6-methyladenosine modified RNA in Alzheimer's disease	5R01AG080810-02
2024	Circular RNAs and their interactions with RNA-binding proteins to modulate AD-related neuropathology	5U01AG072577-04
2024	Circular RNAs and their interactions with RNA-binding proteins to modulate AD-related neuropathology	3U01AG072577-04S1
2023	The role of N6-methyladenosine modified RNA in Alzheimer's disease	1R01AG080810-01
2023	The role of N6-methyladenosine modified RNA in Alzheimer's disease: Equipment Supplement	3R01AG080810-01S1

Showing 10 of 13 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Huang J, Rehman H, Doan C, Stein TD, Mez J, Ang TFA, Tao Q, Au R, Farrer LA, Zhang X, Qiu WQ. Circulating C-reactive protein influences polygenic risk of inflammatory genes expressed in brain endothelia for Alzheimer's disease. Neurobiol Dis. 2026 Feb; 219:107257.View Related Profiles.

Rehman, Habbiburr
Mez, Jesse
Farrer, Lindsay
Tao, Qiushan
Au, Rhoda
Stein, Thor
Ang, Ting Fang Alvin
Qiu, Wendy
Zhang, Xiaoling

PMID: 41539445; PMCID: PMC12919661; DOI: 10.1016/j.nbd.2026.107257;

Olayinka OA, O'Neill N, Empawi JA, Bock P, Hu J, Rickner H, Wong M, Stein TD, Wolozin B, Farrer LA, Zhang X. Single nucleus RNA sequencing unveils relationship between microglia and endothelial cells in mixed Alzheimer's disease and vascular pathology. Neurobiol Dis. 2025 Nov; 216:107128.View Related Profiles.

Wolozin, Benjamin
Farrer, Lindsay
Zhang, Xiaoling

PMID: 41022229; PMCID: PMC12668424; DOI: 10.1016/j.nbd.2025.107128;

Kurniansyah N, Tasaki S, Rehman H, Zhu C, Farrell J, Sherva R, Hauger R, Merritt VC, Panizzon M, Zhang R, Gaziano JM, Gim J, Lee K, Lee DY, Nho K, Vialle RA, Mukherjee S, Trittschuh EH, Lee AJ, Brickman AM, Cruchaga C, Risacher S, Greve DN, Crane P, Martin E, Bush W, Mayeux R, Haines JL, Pericak-Vance MA, Logue M, Bennett DA, Barnes LL, Saykin A, Hohman T, Wang LS, Schellenberg GC, Ang TFA, Au R, Mez J, Lunetta KL, Zhang X, Farrer LA. A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations. medRxiv. 2025 Sep 27.View Related Profiles.

Rehman, Habbiburr
Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Logue, Mark
Au, Rhoda
Sherva, Richard
Zhang, Xiaoling

PMID: 41040715; PMCID: PMC12486013; DOI: 10.1101/2025.09.24.25336555;

Huang J, Wang Y, Stein TD, Ang TFA, Zhu Y, Tao Q, Lunetta KL, Mez J, Au R, Farrer LA, Qiu WQ, Zhang X. The impact of blood MCP-1 levels on Alzheimer's disease with genetic variation at the NAV3 and UNC5C loci. Transl Psychiatry. 2025 Aug 19; 15(1):296.View Related Profiles.

Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Tao, Qiushan
Au, Rhoda
Stein, Thor
Ang, Ting Fang Alvin
Qiu, Wendy
Zhang, Xiaoling

PMID: 40830334; PMCID: PMC12365253; DOI: 10.1038/s41398-025-03542-w;

Shi Y, He X, Liu W, Hu J, Qiu WQ, Zhang X, Fan Z. Associations of diabetes mellitus with primary open angle glaucoma and Alzheimer's disease: a large cohort study in UK biobank. Front Endocrinol (Lausanne). 2025; 16:1506560.View Related Profiles.

Qiu, Wendy
Zhang, Xiaoling

PMID: 40778276; PMCID: PMC12328150; DOI: 10.3389/fendo.2025.1506560;

Andrews SJ, Mitchell BA, Tong T, Bonham LW, Renton AE, Zhang X, Sirota M, Tosun D, Yaffe K. Integrative effects of Telomere Length, Epigenetic Age, and Mitochondrial DNA abundance in Alzheimer's Disease. medRxiv. 2025 Jul 17. PMID: 40791717; PMCID: PMC12338940; DOI: 10.1101/2025.07.16.25331683;

Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, da Fonseca EL, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Ikeuchi T, Iqbal T, Pathak O, Valladares O, Reyes-Dumeyer D, Kuzma AB, Abner E, Adams LD, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Auerbach S, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Friedland RP, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Go RCP, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kikuchi M, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, Obisesan T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Petrovitch H, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sabbagh M, Sadovnick AD, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, George-Hyslop PS, Starks TD, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsolaki M, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, Wingo TS, Wisniewski T, Woltjer RL, Woon M, Wright CB, Wu CK, Younkin SG, Yu CE, Yu L, Zhu X, Kunkle BW, Bush WS, Miyashita A, Byrd GS, Wang LS, Farrer LA, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Jun GR, Reitz C, Naj AC. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease. Genome Biol. 2025 Jul 17; 26(1):210.View Related Profiles.

McKee, Ann
Jun, Gyungah
Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Logue, Mark
Kowall, Neil
Sherva, Richard
Stern, Robert
Auerbach, Sanford
Zhang, Xiaoling

PMID: 40676597; PMCID: PMC12273372; DOI: 10.1186/s13059-025-03564-z;

O'Neill N, Kurniansyah N, Zhu C, Olayinka OA, Mayeux R, Haines JL, Pericak-Vance MA, Wang LS, Schellenberg GD, Farrer LA, Zhang X. Multi-omic derived cell-type specific Alzheimer disease polygenic risk scores. Neurobiol Aging. 2025 Nov; 155:44-52.View Related Profiles.

Farrer, Lindsay
Zhang, Xiaoling

PMID: 40706314; DOI: 10.1016/j.neurobiolaging.2025.07.009;

Libera JL, Hu J, Nguyen TA, Wang Z, van der Spek SJF, Schult K, Dorrian L, Majka J, Tobunluepop K, Puri S, Kynshov A, Kanaan NM, Nelson PT, Meyer K, Hou L, Zhang X, Wolozin B. Loss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease. bioRxiv. 2025 May 07.View Related Profiles.

Wolozin, Benjamin
Hou, Lei
Puri, Sambhavi
Van Der Spek, Sophie
Zhang, Xiaoling

PMID: 40654675; PMCID: PMC12247753; DOI: 10.1101/2025.05.02.651974;

Leung YY, Lee WP, Kuzma AB, Nicaretta H, Valladares O, Gangadharan P, Qu L, Zhao Y, Ren Y, Cheng PL, Kuksa PP, Wang H, White H, Katanic Z, Bass L, Saravanan N, Greenfest-Allen E, Kirsch M, Cantwell L, Iqbal T, Wheeler NR, Farrell JJ, Zhu C, Turner SL, Gunasekaran TI, Mena PR, Jin Y, Carter L, Zhang X, Vardarajan BN, Toga A, Cuccaro M, Hohman TJ, Bush WS, Naj AC, Martin E, Dalgard CL, Kunkle BW, Farrer LA, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Wang LS. Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset. Alzheimers Dement. 2025 May; 21(5):e70237.View Related Profiles.

Farrer, Lindsay
Zhang, Xiaoling

PMID: 40407102; PMCID: PMC12100500; DOI: 10.1002/alz.70237;

Showing 10 of 76 results. Show More

Rehman H, Ang TFA, Tao Q, Au R, Farrer LA, Qiu WQ, Zhang X. Plasma protein risk scores for mild cognitive impairment and Alzheimer's disease in the Framingham heart study. Alzheimers Dement. 2025 Mar; 21(3):e70066.View Related Profiles.

Rehman, Habbiburr
Farrer, Lindsay
Tao, Qiushan
Au, Rhoda
Ang, Ting Fang Alvin
Qiu, Wendy
Zhang, Xiaoling

PMID: 40156298; PMCID: PMC11953566; DOI: 10.1002/alz.70066;

Shi Y, Liu W, Hu J, Qiu WQ, He X, Gao Y, Zhang X, Fan Z. The Role of Menopause and Its Association with the Apolipoprotein E4 Allele for Age at Diagnosis of Glaucoma in Women. Ophthalmol Sci. 2025; 5(4):100726.View Related Profiles.

Qiu, Wendy
Zhang, Xiaoling

PMID: 40212930; PMCID: PMC11985040; DOI: 10.1016/j.xops.2025.100726;

Tong T, Zhu C, Farrell JJ, Khurshid Z, Martin ER, Pericak-Vance MA, Wang LS, Bush WS, Schellenberg GD, Haines JL, Qiu WQ, Lunetta KL, Farrer LA, Zhang X. Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites. Alzheimers Res Ther. 2024 Oct 23; 16(1):234.View Related Profiles.

Lunetta, Kathryn
Farrer, Lindsay
Qiu, Wendy
Zhang, Xiaoling

PMID: 39444005; PMCID: PMC11515778; DOI: 10.1186/s13195-024-01601-w;

Lee WP, Choi SH, Shea MG, Cheng PL, Dombroski BA, Pitsillides AN, Heard-Costa NL, Wang H, Bulekova K, Kuzma AB, Leung YY, Farrell JJ, Lin H, Kunkle BW, Naj A, Blue EE, Nusetor F, Wang D, Boerwinkle E, Bush WS, Zhang X, De Jager PL, Dupuis J, Farrer LA, Fornage M, Martin E, Pericak-Vance M, Seshadri S, Wijsman EM, Wang LS, Schellenberg GD, Destefano AL, Haines JL, Peloso GM. Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. Alzheimers Dement. 2024 Dec; 20(12):8470-8483.View Related Profiles.

DeStefano, Anita
Peloso, Gina
Lin, Honghuang
Dupuis, Josee
Bulekova, Katia
Farrer, Lindsay
Heard-Costa, Nancy
Choi, Seung Hoan
Seshadri, Sudha
Zhang, Xiaoling

PMID: 39428839; PMCID: PMC11667527; DOI: 10.1002/alz.14283;

O'Neill N, Stein TD, Olayinka OA, Empawi JA, Hu J, Tong T, Zhang X, Farrer LA. Cognitive resilience to Alzheimer's disease characterized by cell-type abundance. Alzheimers Dement. 2024 Oct; 20(10):6910-6921.View Related Profiles.

Farrer, Lindsay
Stein, Thor
Zhang, Xiaoling

PMID: 39262221; PMCID: PMC12060125; DOI: 10.1002/alz.14187;

Shi Y, Hu J, Liu W, Qiu WQ, He X, Zhang M, Gao Y, Zhang X, Fan Z. Female-Specific Association between the Apolipoprotein E E4 Allele and Age at Diagnosis of Glaucoma in UK Biobank. Ophthalmol Glaucoma. 2025; 8(1):53-62.View Related Profiles.

Qiu, Wendy
Zhang, Xiaoling

PMID: 39097094; DOI: 10.1016/j.ogla.2024.07.009;

Wang Y, Huang J, Ang TFA, Zhu Y, Tao Q, Mez J, Alosco M, Denis GV, Belkina A, Gurnani A, Ross M, Gong B, Han J, Lunetta KL, Stein TD, Au R, Farrer LA, Zhang X, Qiu WQ. The association between circulating CD34+CD133+ endothelial progenitor cells and reduced risk of Alzheimer's disease in the Framingham Heart Study. Explor Med. 2024; 5(2):193-214.View Related Profiles.

Belkina, Anna
Gurnani, Ashita
Denis, Gerald
Mez, Jesse
Han, Jingyan
Lunetta, Kathryn
Farrer, Lindsay
Alosco, Michael
Tao, Qiushan
Au, Rhoda
Stein, Thor
Ang, Ting Fang Alvin
Qiu, Wendy
Zhang, Xiaoling

PMID: 38854406; PMCID: PMC11160969; DOI: 10.37349/emed.2024.00216;

Zhu C, Tong T, Farrell JJ, Martin ER, Bush WS, Pericak-Vance MA, Wang LS, Schellenberg GD, Haines JL, Lunetta KL, Farrer LA, Zhang X. MitoH3: Mitochondrial Haplogroup and Homoplasmic/Heteroplasmic Variant Calling Pipeline for Alzheimer's Disease Sequencing Project. J Alzheimers Dis Rep. 2024; 8(1):575-587.View Related Profiles.

Lunetta, Kathryn
Farrer, Lindsay
Zhang, Xiaoling

PMID: 38746629; PMCID: PMC11091720; DOI: 10.3233/ADR-230120;

Rehman H, Ang TFA, Tao Q, Espenilla AL, Au R, Farrer LA, Zhang X, Qiu WQ. Comparison of Commonly Measured Plasma and Cerebrospinal Fluid Proteins and Their Significance for the Characterization of Cognitive Impairment Status. J Alzheimers Dis. 2024; 97(2):621-633.View Related Profiles.

Rehman, Habbiburr
Farrer, Lindsay
Tao, Qiushan
Au, Rhoda
Ang, Ting Fang Alvin
Qiu, Wendy
Zhang, Xiaoling

PMID: 38143358

Tao Q, Zhang C, Mercier G, Lunetta K, Ang TFA, Akhter-Khan S, Zhang Z, Taylor A, Killiany RJ, Alosco M, Mez J, Au R, Zhang X, Farrer LA, Qiu WWQ. Identification of an APOE e4-specific blood-based molecular pathway for Alzheimer's disease risk. Alzheimers Dement (Amst). 2023; 15(4):e12490.View Related Profiles.

Taylor, Andrew
Zhang, Chao
Mercier, Gustavo
Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Alosco, Michael
Tao, Qiushan
Au, Rhoda
Ang, Ting Fang Alvin
Qiu, Wendy
Zhang, Xiaoling

PMID: 37854772; PMCID: PMC10579631; DOI: 10.1002/dad2.12490;

Huang J, Wang Y, Stein TD, Ang TFA, Zhu Y, Tao Q, Lunetta KL, Mez J, Au R, Farrer LA, Qiu WQ, Zhang X. The impact of blood MCP-1 levels on Alzheimer's disease with genetic variation of UNC5C and NAV3 loci. Res Sq. 2023 Sep 28.View Related Profiles.

Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Tao, Qiushan
Au, Rhoda
Stein, Thor
Ang, Ting Fang Alvin
Qiu, Wendy
Zhang, Xiaoling

PMID: 37841863; PMCID: PMC10571626; DOI: 10.21203/rs.3.rs-3376348/v1;

O'Neill NK, Stein TD, Hu J, Rehman H, Campbell JD, Yajima M, Zhang X, Farrer LA. Bulk brain tissue cell-type deconvolution with bias correction for single-nuclei RNA sequencing data using DeTREM. BMC Bioinformatics. 2023 Sep 19; 24(1):349.View Related Profiles.

Rehman, Habbiburr
Campbell, Joshua
Farrer, Lindsay
Stein, Thor
Zhang, Xiaoling

PMID: 37726653; PMCID: PMC10507917; DOI: 10.1186/s12859-023-05476-w;

Puri S, Hu J, Sun Z, Lin M, Stein TD, Farrer LA, Wolozin B, Zhang X. Identification of circRNAs linked to Alzheimer's disease and related dementias. Alzheimers Dement. 2023 Aug; 19(8):3389-3405.View Related Profiles.

Wolozin, Benjamin
Farrer, Lindsay
Puri, Sambhavi
Stein, Thor
Zhang, Xiaoling

PMID: 36795937; PMCID: PMC10427739; DOI: 10.1002/alz.12960;

Huang J, Tao Q, Ang TFA, Farrell J, Zhu C, Wang Y, Stein TD, Lunetta KL, Massaro J, Mez J, Au R, Farrer LA, Qiu WQ, Zhang X. The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in Alzheimer's disease. Transl Psychiatry. 2022 Dec 22; 12(1):523.View Related Profiles.

Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Tao, Qiushan
Au, Rhoda
Stein, Thor
Ang, Ting Fang Alvin
Qiu, Wendy
Zhang, Xiaoling

PMID: 36550123; PMCID: PMC9780312; DOI: 10.1038/s41398-022-02281-6;

Huang J, Stein TD, Wang Y, Ang TFA, Tao Q, Lunetta KL, Massaro J, Akhter-Khan SC, Mez J, Au R, Farrer LA, Zhang X, Qiu WQ. Blood levels of MCP-1 modulate the genetic risks of Alzheimer's disease mediated by HLA-DRB1 and APOE for Alzheimer's disease. Alzheimers Dement. 2023 May; 19(5):1925-1937.View Related Profiles.

Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Tao, Qiushan
Au, Rhoda
Stein, Thor
Ang, Ting Fang Alvin
Qiu, Wendy
Zhang, Xiaoling

PMID: 36396603; PMCID: PMC10182187; DOI: 10.1002/alz.12851;

Tao Q, Akhter-Khan SC, Ang TFA, DeCarli C, Alosco ML, Mez J, Killiany R, Devine S, Rokach A, Itchapurapu IS, Zhang X, Lunetta KL, Steffens DC, Farrer LA, Greve DN, Au R, Qiu WQ. Different loneliness types, cognitive function, and brain structure in midlife: Findings from the Framingham Heart Study. EClinicalMedicine. 2022 Nov; 53:101643.View Related Profiles.

Itchapurapu, Indira Swetha
Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Alosco, Michael
Tao, Qiushan
Au, Rhoda
Killiany, Ronald
Devine, Sherral
Ang, Ting Fang Alvin
Qiu, Wendy
Zhang, Xiaoling

PMID: 36105871; PMCID: PMC9465265; DOI: 10.1016/j.eclinm.2022.101643;

Chung J, Das A, Sun X, Sobreira DR, Leung YY, Igartua C, Mozaffari S, Chou YF, Thiagalingam S, Mez J, Zhang X, Jun GR, Stein TD, Kunkle BW, Martin ER, Pericak-Vance MA, Mayeux R, Haines JL, Schellenberg GD, Nobrega MA, Lunetta KL, Pinto JM, Wang LS, Ober C, Farrer LA. Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women. Alzheimers Dement. 2023 Mar; 19(3):896-908.View Related Profiles.

Jun, Gyungah
Chung, Jaeyoon
Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Thiagalingam, Sam
Stein, Thor
Zhang, Xiaoling

PMID: 35770850; PMCID: PMC9800643; DOI: 10.1002/alz.12719;

Olayinka OA, O'Neill NK, Farrer LA, Wang G, Zhang X. Molecular Quantitative Trait Locus Mapping in Human Complex Diseases. Curr Protoc. 2022 May; 2(5):e426.View Related Profiles.

Farrer, Lindsay
Zhang, Xiaoling

PMID: 35587224; PMCID: PMC9186089; DOI: 10.1002/cpz1.426;

Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, Holmans PA, Boland A, Damotte V, van der Lee SJ, Costa MR, Kuulasmaa T, Yang Q, de Rojas I, Bis JC, Yaqub A, Prokic I, Chapuis J, Ahmad S, Giedraitis V, Aarsland D, Garcia-Gonzalez P, Abdelnour C, Alarcón-Martín E, Alcolea D, Alegret M, Alvarez I, Álvarez V, Armstrong NJ, Tsolaki A, Antúnez C, Appollonio I, Arcaro M, Archetti S, Pastor AA, Arosio B, Athanasiu L, Bailly H, Banaj N, Baquero M, Barral S, Beiser A, Pastor AB, Below JE, Benchek P, Benussi L, Berr C, Besse C, Bessi V, Binetti G, Bizarro A, Blesa R, Boada M, Boerwinkle E, Borroni B, Boschi S, Bossù P, Bråthen G, Bressler J, Bresner C, Brodaty H, Brookes KJ, Brusco LI, Buiza-Rueda D, Bûrger K, Burholt V, Bush WS, Calero M, Cantwell LB, Chene G, Chung J, Cuccaro ML, Carracedo Á, Cecchetti R, Cervera-Carles L, Charbonnier C, Chen HH, Chillotti C, Ciccone S, Claassen JAHR, Clark C, Conti E, Corma-Gómez A, Costantini E, Custodero C, Daian D, Dalmasso MC, Daniele A, Dardiotis E, Dartigues JF, de Deyn PP, de Paiva Lopes K, de Witte LD, Debette S, Deckert J, Del Ser T, Denning N, DeStefano A, Dichgans M, Diehl-Schmid J, Diez-Fairen M, Rossi PD, Djurovic S, Duron E, Düzel E, Dufouil C, Eiriksdottir G, Engelborghs S, Escott-Price V, Espinosa A, Ewers M, Faber KM, Fabrizio T, Nielsen SF, Fardo DW, Farotti L, Fenoglio C, Fernández-Fuertes M, Ferrari R, Ferreira CB, Ferri E, Fin B, Fischer P, Fladby T, Fließbach K, Fongang B, Fornage M, Fortea J, Foroud TM, Fostinelli S, Fox NC, Franco-Macías E, Bullido MJ, Frank-García A, Froelich L, Fulton-Howard B, Galimberti D, García-Alberca JM, García-González P, Garcia-Madrona S, Garcia-Ribas G, Ghidoni R, Giegling I, Giorgio G, Goate AM, Goldhardt O, Gomez-Fonseca D, González-Pérez A, Graff C, Grande G, Green E, Grimmer T, Grünblatt E, Grunin M, Gudnason V, Guetta-Baranes T, Haapasalo A, Hadjigeorgiou G, Haines JL, Hamilton-Nelson KL, Hampel H, Hanon O, Hardy J, Hartmann AM, Hausner L, Harwood J, Heilmann-Heimbach S, Helisalmi S, Heneka MT, Hernández I, Herrmann MJ, Hoffmann P, Holmes C, Holstege H, Vilas RH, Hulsman M, Humphrey J, Biessels GJ, Jian X, Johansson C, Jun GR, Kastumata Y, Kauwe J, Kehoe PG, Kilander L, Ståhlbom AK, Kivipelto M, Koivisto A, Kornhuber J, Kosmidis MH, Kukull WA, Kuksa PP, Kunkle BW, Kuzma AB, Lage C, Laukka EJ, Launer L, Lauria A, Lee CY, Lehtisalo J, Lerch O, Lleó A, Longstreth W, Lopez O, de Munain AL, Love S, Löwemark M, Luckcuck L, Lunetta KL, Ma Y, Macías J, MacLeod CA, Maier W, Mangialasche F, Spallazzi M, Marquié M, Marshall R, Martin ER, Montes AM, Rodríguez CM, Masullo C, Mayeux R, Mead S, Mecocci P, Medina M, Meggy A, Mehrabian S, Mendoza S, Menéndez-González M, Mir P, Moebus S, Mol M, Molina-Porcel L, Montrreal L, Morelli L, Moreno F, Morgan K, Mosley T, Nöthen MM, Muchnik C, Mukherjee S, Nacmias B, Ngandu T, Nicolas G, Nordestgaard BG, Olaso R, Orellana A, Orsini M, Ortega G, Padovani A, Paolo C, Papenberg G, Parnetti L, Pasquier F, Pastor P, Peloso G, Pérez-Cordón A, Pérez-Tur J, Pericard P, Peters O, Pijnenburg YAL, Pineda JA, Piñol-Ripoll G, Pisanu C, Polak T, Popp J, Posthuma D, Priller J, Puerta R, Quenez O, Quintela I, Thomassen JQ, Rábano A, Rainero I, Rajabli F, Ramakers I, Real LM, Reinders MJT, Reitz C, Reyes-Dumeyer D, Ridge P, Riedel-Heller S, Riederer P, Roberto N, Rodriguez-Rodriguez E, Rongve A, Allende IR, Rosende-Roca M, Royo JL, Rubino E, Rujescu D, Sáez ME, Sakka P, Saltvedt I, Sanabria Á, Sánchez-Arjona MB, Sanchez-Garcia F, Juan PS, Sánchez-Valle R, Sando SB, Sarnowski C, Satizabal CL, Scamosci M, Scarmeas N, Scarpini E, Scheltens P, Scherbaum N, Scherer M, Schmid M, Schneider A, Schott JM, Selbæk G, Seripa D, Serrano M, Sha J, Shadrin AA, Skrobot O, Slifer S, Snijders GJL, Soininen H, Solfrizzi V, Solomon A, Song Y, Sorbi S, Sotolongo-Grau O, Spalletta G, Spottke A, Squassina A, Stordal E, Tartan JP, Tárraga L, Tesí N, Thalamuthu A, Thomas T, et al. NewView Related Profiles.

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DeStefano, Anita
Satizabal, Claudia
Peloso, Gina
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Lunetta, Kathryn
Farrer, Lindsay
Yang, Qiong
Seshadri, Sudha
Zhang, Xiaoling

PMID: 35379992; PMCID: PMC9005347; DOI: 10.1038/s41588-022-01024-z;

Castaneda AB, Petty LE, Scholz M, Jansen R, Weiss S, Zhang X, Schramm K, Beutner F, Kirsten H, Schminke U, Hwang SJ, Marzi C, Dhana K, Seldenrijk A, Krohn K, Homuth G, Wolf P, Peters MJ, Dörr M, Peters A, van Meurs JBJ, Uitterlinden AG, Kavousi M, Levy D, Herder C, van Grootheest G, Waldenberger M, Meisinger C, Rathmann W, Thiery J, Polak J, Koenig W, Seissler J, Bis JC, Franceshini N, Giambartolomei C, Hofman A, Franco OH, Penninx BWJH, Prokisch H, Völzke H, Loeffler M, O'Donnell CJ, Below JE, Dehghan A, de Vries PS. Associations of carotid intima media thickness with gene expression in whole blood and genetically predicted gene expression across 48 tissues. Hum Mol Genet. 2022 Mar 31; 31(7):1171-1182.View Related Profiles.

O'Donnell, Christopher
Polak, Joseph
Hwang, Shih-Jen
Zhang, Xiaoling

PMID: 34788810; PMCID: PMC8976428; DOI: 10.1093/hmg/ddab236;

Zhang X, Tong T, Chang A, Ang TFA, Tao Q, Auerbach S, Devine S, Qiu WQ, Mez J, Massaro J, Lunetta KL, Au R, Farrer LA. Midlife lipid and glucose levels are associated with Alzheimer's disease. Alzheimers Dement. 2023 Jan; 19(1):181-193.View Related Profiles.

Chang, Andrew
Mez, Jesse
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Lunetta, Kathryn
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Tao, Qiushan
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Auerbach, Sanford
Devine, Sherral
Ang, Ting Fang Alvin
Qiu, Wendy
Zhang, Xiaoling

PMID: 35319157; PMCID: PMC10078665; DOI: 10.1002/alz.12641;

Zhang Z, Na H, Gan Q, Tao Q, Alekseyev Y, Hu J, Yan Z, Yang JB, Tian H, Zhu S, Li Q, Rajab IM, Blusztajn JK, Wolozin B, Emili A, Zhang X, Stein T, Potempa LA, Qiu WQ. Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease? Aging Cell. 2021 11; 20(11):e13501.View Related Profiles.

Emili, Andrew
Wolozin, Benjamin
Blusztajn, Jan
Tao, Qiushan
Stein, Thor
Qiu, Wendy
Zhang, Xiaoling
Alekseyev, Yuriy

PMID: 34687487; PMCID: PMC8590103; DOI: 10.1111/acel.13501;

Tao Q, Alvin Ang TF, Akhter-Khan SC, Itchapurapu IS, Killiany R, Zhang X, Budson AE, Turk KW, Goldstein L, Mez J, Alosco ML, Qiu WQ. Impact of C-Reactive Protein on Cognition and Alzheimer Disease Biomarkers in Homozygous APOE ?4 Carriers. Neurology. 2021 Sep 20; 97(12):e1243-e1252.View Related Profiles.

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Killiany, Ronald
Qiu, Wendy
Zhang, Xiaoling

PMID: 34266923; PMCID: PMC8480484; DOI: 10.1212/WNL.0000000000012512;

Zhang X, Farrell JJ, Tong T, Hu J, Zhu C, Wang LS, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Farrer LA. Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease. Alzheimers Dement. 2022 02; 18(2):294-306.View Related Profiles.

Lunetta, Kathryn
Farrer, Lindsay
Zhang, Xiaoling

PMID: 34152079; PMCID: PMC8764625; DOI: 10.1002/alz.12396;

Patel D, Zhang X, Farrell JJ, Chung J, Stein TD, Lunetta KL, Farrer LA. Cell-type-specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue. Transl Psychiatry. 2021 04 27; 11(1):250.View Related Profiles.

Chung, Jaeyoon
Lunetta, Kathryn
Farrer, Lindsay
Stein, Thor
Zhang, Xiaoling

PMID: 33907181; PMCID: PMC8079392; DOI: 10.1038/s41398-021-01373-z;

Patel D, Zhang X, Farrell JJ, Lunetta KL, Farrer LA. Set-Based Rare Variant Expression Quantitative Trait Loci in Blood and Brain from Alzheimer Disease Study Participants. Genes (Basel). 2021 03 15; 12(3).View Related Profiles.

Lunetta, Kathryn
Farrer, Lindsay
Zhang, Xiaoling

PMID: 33804025; PMCID: PMC7999141; DOI: 10.3390/genes12030419;

Zhang X, van Rooij JGJ, Wakabayashi Y, Hwang SJ, Yang Y, Ghanbari M, Bos D, Levy D, Johnson AD, van Meurs JBJ, Kavousi M, Zhu J, O'Donnell CJ. Genome-wide transcriptome study using deep RNA sequencing for myocardial infarction and coronary artery calcification. BMC Med Genomics. 2021 02 10; 14(1):45.View Related Profiles.

O'Donnell, Christopher
Hwang, Shih-Jen
Zhang, Xiaoling

PMID: 33568140; PMCID: PMC7874462; DOI: 10.1186/s12920-020-00838-2;

Malhotra R, Mauer AC, Lino Cardenas CL, Guo X, Yao J, Zhang X, Wunderer F, Smith AV, Wong Q, Pechlivanis S, Hwang SJ, Wang J, Lu L, Nicholson CJ, Shelton G, Buswell MD, Barnes HJ, Sigurslid HH, Slocum C, Rourke CO, Rhee DK, Bagchi A, Nigwekar SU, Buys ES, Campbell CY, Harris T, Budoff M, Criqui MH, Rotter JI, Johnson AD, Song C, Franceschini N, Debette S, Hoffmann U, Kälsch H, Nöthen MM, Sigurdsson S, Freedman BI, Bowden DW, Jöckel KH, Moebus S, Erbel R, Feitosa MF, Gudnason V, Thanassoulis G, Zapol WM, Lindsay ME, Bloch DB, Post WS, O'Donnell CJ. HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. Nat Genet. 2019 11; 51(11):1580-1587.View Related Profiles.

O'Donnell, Christopher
Hwang, Shih-Jen
Zhang, Xiaoling

PMID: 31659325; PMCID: PMC6858575; DOI: 10.1038/s41588-019-0514-8;

Ma Y, Jun GR, Zhang X, Chung J, Naj AC, Chen Y, Bellenguez C, Hamilton-Nelson K, Martin ER, Kunkle BW, Bis JC, Debette S, DeStefano AL, Fornage M, Nicolas G, van Duijn C, Bennett DA, De Jager PL, Mayeux R, Haines JL, Pericak-Vance MA, Seshadri S, Lambert JC, Schellenberg GD, Lunetta KL, Farrer LA. Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype. JAMA Neurol. 2019 Sep 01; 76(9):1099-1108.View Related Profiles.

DeStefano, Anita
Jun, Gyungah
Chung, Jaeyoon
Lunetta, Kathryn
Farrer, Lindsay
Seshadri, Sudha
Zhang, Xiaoling

PMID: 31180460; PMCID: PMC6563544; DOI: 10.1001/jamaneurol.2019.1456;

Choi KY, Lee JJ, Gunasekaran TI, Kang S, Lee W, Jeong J, Lim HJ, Zhang X, Zhu C, Won SY, Choi YY, Seo EH, Lee SC, Gim J, Chung JY, Chong A, Byun MS, Seo S, Ko PW, Han JW, McLean C, Farrell J, Lunetta KL, Miyashita A, Hara N, Won S, Choi SM, Ha JM, Jeong JH, Kuwano R, Song MK, An SSA, Lee YM, Park KW, Lee HW, Choi SH, Rhee S, Song WK, Lee JS, Mayeux R, Haines JL, Pericak-Vance MA, Choo ILH, Nho K, Kim KW, Lee DY, Kim S, Kim BC, Kim H, Jun GR, Schellenberg GD, Ikeuchi T, Farrer LA, Lee KH, Neuroimaging Initative AD. APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE e4 on Alzheimer's Disease Risk in a Multiracial Sample. J Clin Med. 2019 Aug 16; 8(8).View Related Profiles.

Jun, Gyungah
Lunetta, Kathryn
Farrer, Lindsay
Zhang, Xiaoling

PMID: 31426376; PMCID: PMC6723529; DOI: 10.3390/jcm8081236;

Zhu H, Tao Q, Ang TFA, Massaro J, Gan Q, Salim S, Zhu RY, Kolachalama VB, Zhang X, Devine S, Auerbach SH, DeCarli C, Au R, Qiu WQ. Association of Plasma Amylin Concentration With Alzheimer Disease and Brain Structure in Older Adults. JAMA Netw Open. 2019 08 02; 2(8):e199826.View Related Profiles.

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Massaro, Joseph
Tao, Qiushan
Au, Rhoda
Auerbach, Sanford
Devine, Sherral
Ang, Ting Fang Alvin
Kolachalama, Vijaya
Qiu, Wendy
Zhang, Xiaoling

PMID: 31433485; PMCID: PMC6707010; DOI: 10.1001/jamanetworkopen.2019.9826;

Guo C, Zhao Z, Chen D, He S, Sun N, Li Z, Liu J, Zhang D, Zhang J, Li J, Zhang M, Ge J, Liu X, Zhang X, Fan Z. Detection of Clinically Relevant Genetic Variants in Chinese Patients With Nanophthalmos by Trio-Based Whole-Genome Sequencing Study. Invest Ophthalmol Vis Sci. 2019 07 01; 60(8):2904-2913. PMID: 31266062; DOI: 10.1167/iovs.18-26275;

Ma Y, Jun GR, Chung J, Zhang X, Kunkle BW, Naj AC, White CC, Bennett DA, De Jager PL, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Farrer LA, Lunetta KL. CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease. Aging Cell. 2019 08; 18(4):e12964.View Related Profiles.

Jun, Gyungah
Chung, Jaeyoon
Lunetta, Kathryn
Farrer, Lindsay
Zhang, Xiaoling

PMID: 31144443; PMCID: PMC6612647; DOI: 10.1111/acel.12964;

Patel D, Mez J, Vardarajan BN, Staley L, Chung J, Zhang X, Farrell JJ, Rynkiewicz MJ, Cannon-Albright LA, Teerlink CC, Stevens J, Corcoran C, Gonzalez Murcia JD, Lopez OL, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg G, Kauwe JSK, Lunetta KL, Farrer LA. Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry. JAMA Netw Open. 2019 03 01; 2(3):e191350.View Related Profiles.

Chung, Jaeyoon
Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Rynkiewicz, Michael
Zhang, Xiaoling

PMID: 30924900; PMCID: PMC6450321; DOI: 10.1001/jamanetworkopen.2019.1350;

Zhang X, Zhu C, Beecham G, Vardarajan BN, Ma Y, Lancour D, Farrell JJ, Chung J, Mayeux R, Haines JL, Schellenberg GD, Pericak-Vance MA, Lunetta KL, Farrer LA. A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease. Alzheimers Dement. 2019 03; 15(3):441-452.View Related Profiles.

Chung, Jaeyoon
Lunetta, Kathryn
Farrer, Lindsay
Zhang, Xiaoling

PMID: 30503768; PMCID: PMC6408965; DOI: 10.1016/j.jalz.2018.10.005;

Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O'Donnell CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018 12 03; 9(1):5141.View Related Profiles.

O'Donnell, Christopher
Hwang, Shih-Jen
Seshadri, Sudha
Zhang, Xiaoling

PMID: 30510157; PMCID: PMC6277418; DOI: 10.1038/s41467-018-07340-5;

Abdolmaleky HM, Gower AC, Wong CK, Cox JW, Zhang X, Thiagalingam A, Shafa R, Sivaraman V, Zhou JR, Thiagalingam S. Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality/asymmetry in schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2019 03; 180(2):138-149.View Related Profiles.

Gower, Adam
Wong, Chen Khuan
Thiagalingam, Sam
Zhang, Xiaoling

PMID: 30468562; PMCID: PMC6386618; DOI: 10.1002/ajmg.b.32691;

Tao Q, Ang TFA, DeCarli C, Auerbach SH, Devine S, Stein TD, Zhang X, Massaro J, Au R, Qiu WQ. Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers. JAMA Netw Open. 2018 10 05; 1(6):e183597.View Related Profiles.

Massaro, Joseph
Tao, Qiushan
Au, Rhoda
Auerbach, Sanford
Devine, Sherral
Stein, Thor
Ang, Ting Fang Alvin
Qiu, Wendy
Zhang, Xiaoling

PMID: 30646251; PMCID: PMC6324596; DOI: 10.1001/jamanetworkopen.2018.3597;

Cox JW, Patel D, Chung J, Zhu C, Lent S, Fisher V, Pitsillides A, Farrer L, Zhang X. An efficient analytic approach in genome-wide identification of methylation quantitative trait loci response to fenofibrate treatment. BMC Proc. 2018; 12(Suppl 9):44.View Related Profiles.

Chung, Jaeyoon
Farrer, Lindsay
Zhang, Xiaoling

PMID: 30275893; PMCID: PMC6157188; DOI: 10.1186/s12919-018-0152-7;

Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton-Nelson KL, Bush WS, Salerno WJ, Lancour D, Ma Y, Renton AE, Marcora E, Farrell JJ, Zhao Y, Qu L, Ahmad S, Amin N, Amouyel P, Beecham GW, Below JE, Campion D, Cantwell L, Charbonnier C, Chung J, Crane PK, Cruchaga C, Cupples LA, Dartigues JF, Debette S, Deleuze JF, Fulton L, Gabriel SB, Genin E, Gibbs RA, Goate A, Grenier-Boley B, Gupta N, Haines JL, Havulinna AS, Helisalmi S, Hiltunen M, Howrigan DP, Ikram MA, Kaprio J, Konrad J, Kuzma A, Lander ES, Lathrop M, Lehtimäki T, Lin H, Mattila K, Mayeux R, Muzny DM, Nasser W, Neale B, Nho K, Nicolas G, Patel D, Pericak-Vance MA, Perola M, Psaty BM, Quenez O, Rajabli F, Redon R, Reitz C, Remes AM, Salomaa V, Sarnowski C, Schmidt H, Schmidt M, Schmidt R, Soininen H, Thornton TA, Tosto G, Tzourio C, van der Lee SJ, van Duijn CM, Valladares O, Vardarajan B, Wang LS, Wang W, Wijsman E, Wilson RK, Witten D, Worley KC, Zhang X, Bellenguez C, Lambert JC, Kurki MI, Palotie A, Daly M, Boerwinkle E, Lunetta KL, Destefano AL, Dupuis J, Martin ER, Schellenberg GD, Seshadri S, Naj AC, Fornage M, Farrer LA. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Mol Psychiatry. 2020 08; 25(8):1859-1875.View Related Profiles.

DeStefano, Anita
Sarnowski, Chloe
Lin, Honghuang
Chung, Jaeyoon
Dupuis, Josee
Lunetta, Kathryn
Cupples, L
Farrer, Lindsay
Seshadri, Sudha
Zhang, Xiaoling

PMID: 30108311; PMCID: PMC6375806; DOI: 10.1038/s41380-018-0112-7;

Zhang X, Frame AA, Williams JS, Wainford RD. GNAI2 polymorphic variance associates with salt sensitivity of blood pressure in the Genetic Epidemiology Network of Salt Sensitivity study. Physiol Genomics. 2018 09 01; 50(9):724-725.View Related Profiles.

Frame, Alissa
Williams, Jonathan
Wainford, Richard
Zhang, Xiaoling

PMID: 29906209; PMCID: PMC6172609; DOI: 10.1152/physiolgenomics.00141.2017;

Chung J, Zhang X, Allen M, Wang X, Ma Y, Beecham G, Montine TJ, Younkin SG, Dickson DW, Golde TE, Price ND, Ertekin-Taner N, Lunetta KL, Mez J, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg G, Jun GR, Farrer LA. Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease. Alzheimers Res Ther. 2018 02 20; 10(1):22.View Related Profiles.

Jun, Gyungah
Chung, Jaeyoon
Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Zhang, Xiaoling

PMID: 29458411; PMCID: PMC5819208; DOI: 10.1186/s13195-018-0349-z;

Hwang SJ, Onuma O, Massaro JM, Zhang X, Fu YP, Hoffmann U, Fox CS, O'Donnell CJ. Maintenance of Ideal Cardiovascular Health and Coronary Artery Calcium Progression in Low-Risk Men and Women in the Framingham Heart Study. Circ Cardiovasc Imaging. 2018 01; 11(1):e006209.View Related Profiles.

O'Donnell, Christopher
Massaro, Joseph
Hwang, Shih-Jen
Zhang, Xiaoling

PMID: 29305347; PMCID: PMC5761687; DOI: 10.1161/CIRCIMAGING.117.006209;

Chung J, Wang X, Maruyama T, Ma Y, Zhang X, Mez J, Sherva R, Takeyama H, Lunetta KL, Farrer LA, Jun GR. Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages. Alzheimers Dement. 2018 05; 14(5):623-633.View Related Profiles.

Jun, Gyungah
Chung, Jaeyoon
Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Sherva, Richard
Zhang, Xiaoling

PMID: 29274321; PMCID: PMC5938137; DOI: 10.1016/j.jalz.2017.11.006;

Warren CR, O'Sullivan JF, Friesen M, Becker CE, Zhang X, Liu P, Wakabayashi Y, Morningstar JE, Shi X, Choi J, Xia F, Peters DT, Florido MH, Tsankov AM, Duberow E, Comisar L, Shay J, Jiang X, Meissner A, Musunuru K, Kathiresan S, Daheron L, Zhu J, Gerszten RE, Deo RC, Vasan RS, O'Donnell CJ, Cowan CA. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 2017 Apr 06; 20(4):547-557.e7.View Related Profiles.

O'Donnell, Christopher
Choi, Jihoon
Ramachandran, Vasan
Zhang, Xiaoling

PMID: 28388431; DOI: 10.1016/j.stem.2017.01.010;

Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JSK, Kukull WA, Kunkle BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang LS, Wendlund JR, Winslow AR, Haines J, Mayeux R, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement. 2017 Jul; 13(7):727-738.View Related Profiles.

Jun, Gyungah
Chung, Jaeyoon
Mez, Jesse
Lunetta, Kathryn
Farrer, Lindsay
Logue, Mark
Sherva, Richard
Zhang, Xiaoling

PMID: 28183528; PMCID: PMC5496797; DOI: 10.1016/j.jalz.2016.12.012;

Joehanes R, Zhang X, Huan T, Yao C, Ying SX, Nguyen QT, Demirkale CY, Feolo ML, Sharopova NR, Sturcke A, Schäffer AA, Heard-Costa N, Chen H, Liu PC, Wang R, Woodhouse KA, Tanriverdi K, Freedman JE, Raghavachari N, Dupuis J, Johnson AD, O'Donnell CJ, Levy D, Munson PJ. Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies. Genome Biol. 2017 Jan 25; 18(1):16.View Related Profiles.

O'Donnell, Christopher
Dupuis, Josee
Heard-Costa, Nancy
Zhang, Xiaoling

PMID: 28122634; PMCID: PMC5264466; DOI: 10.1186/s13059-016-1142-6;

Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R, Brody JA, Chen MH, Auer PL, Floyd JS, Huang J, Lange L, van Rooij FJA, Gibbs RA, Metcalf G, Muzny D, Veeraraghavan N, Walter K, Chen L, Yanek L, Becker LC, Peloso GM, Wakabayashi A, Kals M, Metspalu A, Esko T, Fox K, Wallace R, Franceschini N, Matijevic N, Rice KM, Bartz TM, Lyytikäinen LP, Kähönen M, Lehtimäki T, Raitakari OT, Li-Gao R, Mook-Kanamori DO, Lettre G, van Duijn CM, Franco OH, Rich SS, Rivadeneira F, Hofman A, Uitterlinden AG, Wilson JG, Psaty BM, Soranzo N, Dehghan A, Boerwinkle E, Zhang X, Johnson AD, O'Donnell CJ, Johnsen JM, Reiner AP, Ganesh SK, Sankaran VG. Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis. Am J Hum Genet. 2016 09 01; 99(3):785.View Related Profiles.

O'Donnell, Christopher
Peloso, Gina
Zhang, Xiaoling

PMID: 27588453; PMCID: PMC5011073; DOI: 10.1016/j.ajhg.2016.08.002;

Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R, Brody JA, Chen MH, Auer PL, Floyd JS, Huang J, Lange L, van Rooij FJ, Gibbs RA, Metcalf G, Muzny D, Veeraraghavan N, Walter K, Chen L, Yanek L, Becker LC, Peloso GM, Wakabayashi A, Kals M, Metspalu A, Esko T, Fox K, Wallace R, Franceshini N, Matijevic N, Rice KM, Bartz TM, Lyytikäinen LP, Kähönen M, Lehtimäki T, Raitakari OT, Li-Gao R, Mook-Kanamori DO, Lettre G, van Duijn CM, Franco OH, Rich SS, Rivadeneira F, Hofman A, Uitterlinden AG, Wilson JG, Psaty BM, Soranzo N, Dehghan A, Boerwinkle E, Zhang X, Johnson AD, O'Donnell CJ, Johnsen JM, Reiner AP, Ganesh SK, Sankaran VG. Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis. Am J Hum Genet. 2016 Aug 04; 99(2):481-8.View Related Profiles.

O'Donnell, Christopher
Peloso, Gina
Zhang, Xiaoling

PMID: 27486782; PMCID: PMC4974169; DOI: 10.1016/j.ajhg.2016.06.016;

Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits. Nat Genet. 2016 08; 48(8):867-76. PMID: 27399967; PMCID: PMC5145000; DOI: 10.1038/ng.3607;

Huan T, Rong J, Liu C, Zhang X, Tanriverdi K, Joehanes R, Chen BH, Murabito JM, Yao C, Courchesne P, Munson PJ, O'Donnell CJ, Cox N, Johnson AD, Larson MG, Levy D, Freedman JE. Genome-wide identification of microRNA expression quantitative trait loci. Nat Commun. 2015; 6:6601.View Related Profiles.

O'Donnell, Christopher
Liu, Chunyu
Murabito, Joanne
Larson, Martin
Zhang, Xiaoling

PMID: 25791433; PMCID: PMC4369777; DOI: 10.1038/ncomms7601;

Zhang X, Joehanes R, Chen BH, Huan T, Ying S, Munson PJ, Johnson AD, Levy D, O'Donnell CJ. Identification of common genetic variants controlling transcript isoform variation in human whole blood. Nat Genet. 2015 Apr; 47(4):345-52.View Related Profiles.

O'Donnell, Christopher
Zhang, Xiaoling

PMID: 25685889

Huan T, Liu C, Joehanes R, Zhang X, Chen BH, Johnson AD, Yao C, Courchesne P, O'Donnell CJ, Munson PJ, Levy D. A systematic heritability analysis of the human whole blood transcriptome. Hum Genet. 2015 Mar; 134(3):343-58.View Related Profiles.

O'Donnell, Christopher
Liu, Chunyu
Zhang, Xiaoling

PMID: 25585846; PMCID: PMC4339826; DOI: 10.1007/s00439-014-1524-3;

Yao C, Chen BH, Joehanes R, Otlu B, Zhang X, Liu C, Huan T, Tastan O, Cupples LA, Meigs JB, Fox CS, Freedman JE, Courchesne P, O'Donnell CJ, Munson PJ, Keles S, Levy D. Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes. Circulation. 2015 Feb 10; 131(6):536-49.View Related Profiles.

O'Donnell, Christopher
Liu, Chunyu
Levy, Daniel
Cupples, L
Zhang, Xiaoling

PMID: 25533967; PMCID: PMC4369387; DOI: 10.1161/CIRCULATIONAHA.114.010696;

Gottlieb DJ, Hek K, Chen TH, Watson NF, Eiriksdottir G, Byrne EM, Cornelis M, Warby SC, Bandinelli S, Cherkas L, Evans DS, Grabe HJ, Lahti J, Li M, Lehtimäki T, Lumley T, Marciante KD, Pérusse L, Psaty BM, Robbins J, Tranah GJ, Vink JM, Wilk JB, Stafford JM, Bellis C, Biffar R, Bouchard C, Cade B, Curhan GC, Eriksson JG, Ewert R, Ferrucci L, Fülöp T, Gehrman PR, Goodloe R, Harris TB, Heath AC, Hernandez D, Hofman A, Hottenga JJ, Hunter DJ, Jensen MK, Johnson AD, Kähönen M, Kao L, Kraft P, Larkin EK, Lauderdale DS, Luik AI, Medici M, Montgomery GW, Palotie A, Patel SR, Pistis G, Porcu E, Quaye L, Raitakari O, Redline S, Rimm EB, Rotter JI, Smith AV, Spector TD, Teumer A, Uitterlinden AG, Vohl MC, Widen E, Willemsen G, Young T, Zhang X, Liu Y, Blangero J, Boomsma DI, Gudnason V, Hu F, Mangino M, Martin NG, O'Connor GT, Stone KL, Tanaka T, Viikari J, Gharib SA, Punjabi NM, Räikkönen K, Völzke H, Mignot E, Tiemeier H. Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. Mol Psychiatry. 2015 Oct; 20(10):1232-9.View Related Profiles.

O'Connor, George
Zhang, Xiaoling

PMID: 25469926; PMCID: PMC4430294; DOI: 10.1038/mp.2014.133;

Zhang X, Gierman HJ, Levy D, Plump A, Dobrin R, Goring HH, Curran JE, Johnson MP, Blangero J, Kim SK, O'Donnell CJ, Emilsson V, Johnson AD. Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs. BMC Genomics. 2014 Jun 27; 15:532.View Related Profiles.

O'Donnell, Christopher
Zhang, Xiaoling

PMID: 24973796; PMCID: PMC4102726; DOI: 10.1186/1471-2164-15-532;

Bis JC, White CC, Franceschini N, Brody J, Zhang X, Muzny D, Santibanez J, Gibbs R, Liu X, Lin H, Boerwinkle E, Psaty BM, North KE, Cupples LA, O'Donnell CJ. Sequencing of 2 subclinical atherosclerosis candidate regions in 3669 individuals: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet. 2014 Jun; 7(3):359-64.View Related Profiles.

O'Donnell, Christopher
Lin, Honghuang
Cupples, L
Zhang, Xiaoling

PMID: 24951662; PMCID: PMC4112104; DOI: 10.1161/CIRCGENETICS.113.000116;

Zhang X, Johnson AD, Hendricks AE, Hwang SJ, Tanriverdi K, Ganesh SK, Smith NL, Peyser PA, Freedman JE, O'Donnell CJ. Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes. Hum Mol Genet. 2014 Feb 1; 23(3):782-95.View Related Profiles.

O'Donnell, Christopher
Freedman, Jane
Hwang, Shih-Jen
Zhang, Xiaoling

PMID: 24057673; PMCID: PMC3900869; DOI: 10.1093/hmg/ddt461;

Zhang X, Lenburg ME, Spira A. Comparison of nasal epithelial smoking-induced gene expression on Affymetrix Exon 1.0 and Gene 1.0 ST arrays. ScientificWorldJournal. 2013; 2013:951416.View Related Profiles.

Spira, Avrum
Lenburg, Marc
Zhang, Xiaoling

PMID: 23476154; PMCID: PMC3588192; DOI: 10.1155/2013/951416;

Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algül H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP. Hepatocyte-specific mutation of both NF-?B RelA and STAT3 abrogates the acute phase response in mice. J Clin Invest. 2012 May 1; 122(5):1758-63.View Related Profiles.

Spira, Avrum
Mizgerd, Joseph
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
Pelton, Stephen
Sabharwal, Vishakha
Zhang, Xiaoling

PMID: 22466650; PMCID: PMC3336975; DOI: 10.1172/JCI59408;

Zhang X, Sebastiani P, Liu G, Schembri F, Zhang X, Dumas YM, Langer EM, Alekseyev Y, O'Connor GT, Brooks DR, Lenburg ME, Spira A. Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium. Physiol Genomics. 2010 Mar 3; 41(1):1-8.View Related Profiles.

Spira, Avrum
Brooks, Daniel
Schembri, Frank
Liu, Gang
O'Connor, George
Lenburg, Marc
Sebastiani, Paola
Zhang, Xiaoling
Alekseyev, Yuriy
Dumas, Yves-Martine

PMID: 19952278; PMCID: PMC2841495; DOI: 10.1152/physiolgenomics.00167.2009;

Yu L, Coelho JE, Zhang X, Fu Y, Tillman A, Karaoz U, Fredholm BB, Weng Z, Chen JF. Uncovering multiple molecular targets for caffeine using a drug target validation strategy combining A 2A receptor knockout mice with microarray profiling. Physiol Genomics. 2009 May 13; 37(3):199-210.View Related Profiles.

Chen, Jiang-Fan
Yu, Liqun
Zhang, Xiaoling

PMID: 19258493; PMCID: PMC2685498; DOI: 10.1152/physiolgenomics.90353.2008;

Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Zhang X, Bowers J, Vaziri C, Ott K, Sensinger K, Collins JJ, Brody JS, Getts R, Lenburg ME, Spira A. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2319-24.View Related Profiles.

Spira, Avrum
Vaziri, Cyrus
Schembri, Frank
Liu, Gang
Brody, Jerome
Lu, Jining
Lenburg, Marc
Zhang, Xiaoling

PMID: 19168627; PMCID: PMC2650144; DOI: 10.1073/pnas.0806383106;

Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, Asthana S, Malhotra A, Adzhubei I, Greenbaum JA, Andrews RM, Flicek P, Boyle PJ, Cao H, Carter NP, Clelland GK, Davis S, Day N, Dhami P, Dillon SC, Dorschner MO, Fiegler H, Giresi PG, Goldy J, Hawrylycz M, Haydock A, Humbert R, James KD, Johnson BE, Johnson EM, Frum TT, Rosenzweig ER, Karnani N, Lee K, Lefebvre GC, Navas PA, Neri F, Parker SC, Sabo PJ, Sandstrom R, Shafer A, Vetrie D, Weaver M, Wilcox S, Yu M, Collins FS, Dekker J, Lieb JD, Tullius TD, Crawford GE, Sunyaev S, Noble WS, Dunham I, Denoeud F, Reymond A, Kapranov P, Rozowsky J, Zheng D, Castelo R, Frankish A, Harrow J, Ghosh S, Sandelin A, Hofacker IL, Baertsch R, Keefe D, Dike S, Cheng J, Hirsch HA, Sekinger EA, Lagarde J, Abril JF, Shahab A, Flamm C, Fried C, Hackermüller J, Hertel J, Lindemeyer M, Missal K, Tanzer A, Washietl S, Korbel J, Emanuelsson O, Pedersen JS, Holroyd N, Taylor R, Swarbreck D, Matthews N, Dickson MC, Thomas DJ, Weirauch MT, Gilbert J, Drenkow J, Bell I, Zhao X, Srinivasan KG, Sung WK, Ooi HS, Chiu KP, Foissac S, Alioto T, Brent M, Pachter L, Tress ML, Valencia A, Choo SW, Choo CY, Ucla C, Manzano C, Wyss C, Cheung E, Clark TG, Brown JB, Ganesh M, Patel S, Tammana H, Chrast J, Henrichsen CN, Kai C, Kawai J, Nagalakshmi U, Wu J, Lian Z, Lian J, Newburger P, Zhang X, Bickel P, Mattick JS, Carninci P, Hayashizaki Y, Weissman S, Hubbard T, Myers RM, Rogers J, Stadler PF, Lowe TM, Wei CL, Ruan Y, Struhl K, Gerstein M, Antonarakis SE, Fu Y, Green ED, Karaöz U, Siepel A, Taylor J, Liefer LA, Wetterstrand KA, Good PJ, Feingold EA, Guyer MS, Cooper GM, Asimenos G, Dewey CN, Hou M, Nikolaev S, Montoya-Burgos JI, Löytynoja A, Whelan S, Pardi F, Massingham T, Huang H, Zhang NR, Holmes I, Mullikin JC, Ureta-Vidal A, Paten B, Seringhaus M, Church D, Rosenbloom K, Kent WJ, Stone EA, Batzoglou S, Goldman N, Hardison RC, Haussler D, Miller W, Sidow A, Trinklein ND, Zhang ZD, Barrera L, Stuart R, King DC, Ameur A, Enroth S, Bieda MC, Kim J, Bhinge AA, Jiang N, Liu J, Yao F, Vega VB, Lee CW, Ng P, Shahab A, Yang A, Moqtaderi Z, Zhu Z, Xu X, Squazzo S, Oberley MJ, Inman D, Singer MA, Richmond TA, Munn KJ, Rada-Iglesias A, Wallerman O, Komorowski J, Fowler JC, Couttet P, Bruce AW, Dovey OM, Ellis PD, Langford CF, Nix DA, Euskirchen G, Hartman S, Urban AE, Kraus P, Van Calcar S, Heintzman N, Kim TH, Wang K, Qu C, Hon G, Luna R, Glass CK, Rosenfeld MG, Aldred SF, Cooper SJ, Halees A, Lin JM, Shulha HP, Zhang X, Xu M, Haidar JN, Yu Y, Ruan Y, Iyer VR, Green RD, Wadelius C, Farnham PJ, Ren B, Harte RA, Hinrichs AS, Trumbower H, Clawson H, Hillman-Jackson J, Zweig AS, Smith K, Thakkapallayil A, Barber G, Kuhn RM, Karolchik D, Armengol L, Bird CP, de Bakker PI, Kern AD, Lopez-Bigas N, Martin JD, Stranger BE, Woodroffe A, Davydov E, Dimas A, Eyras E, Hallgrímsdóttir IB, Huppert J, Zody MC, Abecasis GR, Estivill X, Bouffard GG, Guan X, Hansen NF, Idol JR, Maduro VV, Maskeri B, McDowell JC, Park M, Thomas PJ, Young AC, Blakesley RW, Muzny DM, Sodergren E, Wheeler DA, Worley KC, Jiang H, Weinstock GM, Gibbs RA, Graves T, Fulton R, Mardis ER, Wilson RK, Clamp M, Cuff J, Gnerre S, Jaffe DB, Chang JL, Lindblad-Toh K, Lander ES, Koriabine M, Nefedov M, Osoegawa K, Yoshinaga Y, Zhu B, de Jong PJ. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007 Jun 14; 447(7146):799-816.View Related Profiles.

Tullius, Thomas
Zhang, Xiaoling

PMID: 17571346; PMCID: PMC2212820; DOI: 10.1038/nature05874;

Zhang X, Liu G, Lenburg ME, Spira A. Comparison of smoking-induced gene expression on Affymetrix Exon and 3'-based expression arrays. Genome Inform. 2007; 18:247-57.View Related Profiles.

Spira, Avrum
Liu, Gang
Lenburg, Marc
Zhang, Xiaoling

PMID: 18546492

Pei, J. Zhang, X., Cho, M., Wang, H & Yu, P.S. . Full Paper. MaPle: A Fast Algorithm for Maximal Pattern-based Clustering. In Proceedings of the Third IEEE International Conference on Data Mining (ICDM'03), USA,. 2003. View Publication

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 76 publications over 17 distinct years, with a maximum of 11 publications in 2025

Bar chart showing 76 publications over 17 distinct years, with a maximum of 11 publications in 2025

Year	Publications
2003	1
2007	2
2009	3
2012	1
2013	2
2014	4
2015	3
2016	3
2017	4
2018	8
2019	8
2021	6
2022	8
2023	4
2024	7
2025	11
2026	1

Media Mentions

Young Adults With High Blood Sugar and Low HDL Have Increased Alzheimer’s Risk

NMN.com 4/5/2022

These Three Health Indicators at 35 Are Linked to Your Risk of Dementia

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Risk of Alzheimer's linked to cholesterol, blood sugar levels at age 35

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Blood Profile at Age 35 Linked to Subsequent Alzheimer's Dementia

Medpage Today 3/25/2022

Ignoring cholesterol and glucose levels at age 35 may impact the chances of getting Alzheimer's later

News Medical 3/23/2022

2021 Boston University School of Medicine: Recipient of the 2021 Spivack Young Investigator Award, Excellence in Neuroscience

2018 Wing Tat Lee International Health Award

2017-2019 Boston University Alzheimer’s Disease Center: Career Development Award

2012 American Heart Association (AHA): Fellow

2008 Boston University School of Medicine: First Prize, Clinical Research Award

2004-2005 Boston University: Presidential Fellowship

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