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MD, All India Institute of Medical Science (AIIMS)
MBBS, Christian Medical College & Hospital
DM, All India Institute of Medical Science (AIIMS)

Websites

	Neurology Faculty
	Alzheimer's Disease Center Faculty
	Boston Medical Center Physician Provider Profile
	BMC Stroke & Cerebrovascular Center

ORCID : 0000-0001-6135-2622

BU Sponsored Research
NIH RePORTER Sponsored Research

MRI, Cognitive, Genetic and Biomarker Precursors of AD & Dementia in Young Adults
06/01/2016 - 01/31/2020 (Co-PI)
PI: Rhoda Au, PhD
NIH/National Institute on Aging
5R01AG033040-08

MRI, Cognitive, Genetic and Biomarker Precursors of AD & Dementia in Young Adults
02/15/2016 - 01/31/2020 (Co-PI)
PI: Rhoda Au, PhD
NIH/National Institute on Aging
5R01AG033040-07

The Genetics and Biomarkers of Small Vessel stroke (Year 1 Funding)
07/01/2017 - 06/30/2018 (PI)
University of Maryland, Baltimore County American Heart Assoc

AD Gene Discovery: Exome Chip, New Endophenotypes & Functional studies in CHARGE
06/01/2016 - 05/31/2018 (PI)
NIH/National Institute on Aging
4R01AG033193-07

An integrated genetic and epigenetic approach to cerebral small vessel disease
04/01/2015 - 03/31/2018 (PI)
University of Texas Health Science Center, Houston NIH NINDS
5R01NS087541-03

Microgial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE Consortium
09/30/2016 - 11/30/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1UH2NS100605-01

Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer Disease in Framingham Cohorts
09/01/2016 - 11/30/2017 (PI)
NIH/National Institute on Aging
1R01AG054076-01

ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model Systems
09/01/2016 - 11/30/2017 (PI)
NIH/National Institute on Aging
1U01AG052409-01

Precursors of Stroke Incidence and Prognosis
03/01/2016 - 11/30/2017 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5R01NS017950-34

Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults
05/15/2015 - 11/30/2017 (PI)
NIH/National Institute on Aging
5R01AG049607-03

Showing 10 of 22 results. Show All Results

Yr	Title	Project-Sub Proj	Pubs
2018	MRI, Cognitive, Genetic and Biomarker Precursors of AD & Dementia in Young Adults	5R01AG033040-09	24
2017	Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE Consortium	5UH2NS100605-02
2017	Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham Cohorts	3R01AG054076-02S1
2017	Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults	5R01AG049607-03	7
2017	MRI, Cognitive, Genetic and Biomarker Precursors of AD & Dementia in Young Adults	5R01AG033040-08	24
2017	Precursors of Stroke Incidence and Prognosis	5R01NS017950-34	328
2016	Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE Consortium	1UH2NS100605-01
2016	ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model Systems	1U01AG052409-01
2016	Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham Cohorts	1R01AG054076-01
2016	Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults	5R01AG049607-02	7

Showing 10 of 31 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Stathopoulou MG, Xie T, Ruggiero D, Chatelin J, Rancier M, Weryha G, Kurth MJ, Aldasoro Arguinano AA, Gorenjak V, Petrelis AM, Dagher G, Dedoussis G, Deloukas P, Lamont J, Marc J, Simmaco M, Schaik RHNV, Innocenti F, Merlin JL, Schneider J, Alizadeh BZ, Ciullo M, Seshadri S, Visvikis-Siest S. A transnational collaborative network dedicated to the study and applications of the vascular endothelial growth factor-A in medical practice: the VEGF Consortium. Clin Chem Lab Med. 2018 Mar 28; 56(4):83-86. PMID: 29087954.

Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Bis JC, Pastinen T, Ruusalepp A, Schadt EE, Koplev S, Björkegren JLM, Codoni V, Civelek M, Smith NL, Trégouët DA, Christophersen IE, Roselli C, Lubitz SA, Ellinor PT, Tai ES, Kooner JS, Kato N, He J, van der Harst P, Elliott P, Chambers JC, Takeuchi F, Johnson AD, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M, Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, Hoed MD, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Amin N, Aparicio HS, Arnett DK, Attia J, Beiser AS, Berr C, Buring JE, Bustamante M, Caso V, Cheng YC, Choi SH, Chowhan A, Cullell N, Dartigues JF, Delavaran H, Delgado P, Dörr M, Engström G, Ford I, Gurpreet WS, Hamsten A, Heitsch L, Hozawa A, Ibanez L, Ilinca A, Ingelsson M, Iwasaki M, Jackson RD, Jood K, Jousilahti P, Kaffashian S, Kalra L, Kamouchi M, Kitazono T, Kjartansson O, Kloss M, Koudstaal PJ, Krupinski J, Labovitz DL, Laurie CC, Levi CR, Li L, Lind L, Lindgren CM, Lioutas V, Liu YM, Lopez OL, Makoto H, Martinez-Majander N, Matsuda K, et al. MultiView Related Profiles.

Beiser, Alexa
DeStefano, Anita
Satizabal, Claudia
Seshadri, Sudha

PMID: 29531354.

Pase MP, Himali JJ, Grima NA, Beiser AS, Satizabal CL, Aparicio HJ, Thomas RJ, Gottlieb DJ, Auerbach SH, Seshadri S. Author response: Sleep architecture and the risk of incident dementia in the community. Neurology. 2018 Mar 06; 90(10):487.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Auerbach, Sanford
Seshadri, Sudha

PMID: 29507137.

Tynkkynen J, Chouraki V, van der Lee SJ, Hernesniemi J, Yang Q, Li S, Beiser A, Larson MG, Sääksjärvi K, Shipley MJ, Singh-Manoux A, Gerszten RE, Wang TJ, Havulinna AS, Würtz P, Fischer K, Demirkan A, Ikram MA, Amin N, Lehtimäki T, Kähönen M, Perola M, Metspalu A, Kangas AJ, Soininen P, Ala-Korpela M, Vasan RS, Kivimäki M, van Duijn CM, Seshadri S, Salomaa V. Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts. Alzheimers Dement. 2018 Feb 28.View Related Profiles.

Beiser, Alexa
Larson, Martin
Seshadri, Sudha

PMID: 29519576.

Blue EE, Bis JC, Dorschner MO, Tsuang DW, Barral SM, Beecham G, Below JE, Bush WS, Butkiewicz M, Cruchaga C, DeStefano A, Farrer LA, Goate A, Haines J, Jaworski J, Jun G, Kunkle B, Kuzma A, Lee JJ, Lunetta KL, Ma Y, Martin E, Naj A, Nato AQ, Navas P, Nguyen H, Reitz C, Reyes D, Salerno W, Schellenberg GD, Seshadri S, Sohi H, Thornton TA, Valadares O, van Duijn C, Vardarajan BN, Wang LS, Boerwinkle E, Dupuis J, Pericak-Vance MA, Mayeux R, Wijsman EM. Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Dement Geriatr Cogn Disord. 2018; 45(1-2):1-17.View Related Profiles.

DeStefano, Anita
Jun, Gyungah
Lunetta, Kathryn
Farrer, Lindsay
Seshadri, Sudha

PMID: 29486463.

Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpeläinen TO, Richard MA, Noordam R, Aslibekyan S, Aschard H, Bartz TM, Dorajoo R, Liu Y, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Tayo BO, Warren HR, Zhao W, Zhou Y, Matoba N, Sofer T, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Giulianini F, Goel A, Harris SE, Hartwig FP, Horimoto ARVR, Hsu FC, Jackson AU, Kähönen M, Kasturiratne A, Kühnel B, Leander K, Lee WJ, Lin KH, 'an Luan J, McKenzie CA, Meian H, Nelson CP, Rauramaa R, Schupf N, Scott RA, Sheu WHH, Stancáková A, Takeuchi F, van der Most PJ, Varga TV, Wang H, Wang Y, Ware EB, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Alfred T, Amin N, Arking D, Aung T, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Braund PS, Brody JA, Broeckel U, Cabrera CP, Cade B, Caizheng Y, Campbell A, Canouil M, Chakravarti A, Chauhan G, Christensen K, Cocca M, Collins FS, Connell JM, de Mutsert R, de Silva HJ, Debette S, Dörr M, Duan Q, Eaton CB, Ehret G, Evangelou E, Faul JD, Fisher VA, Forouhi NG, Franco OH, Friedlander Y, Gao H, Gigante B, Graff M, Gu CC, Gu D, Gupta P, Hagenaars SP, Harris TB, He J, Heikkinen S, Heng CK, Hirata M, Hofman A, Howard BV, Hunt S, Irvin MR, Jia Y, Joehanes R, Justice AE, Katsuya T, Kaufman J, Kerrison ND, Khor CC, Koh WP, Koistinen HA, Komulainen P, Kooperberg C, Krieger JE, Kubo M, Kuusisto J, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lewis CE, Li Y, Lim SH, Lin S, Liu CT, Liu J, Liu J, Liu K, Liu Y, Loh M, Lohman KK, Long J, Louie T, Mägi R, Mahajan A, Meitinger T, Metspalu A, Milani L, Momozawa Y, Morris AP, Mosley TH, Munson P, Murray AD, Nalls MA, Nasri U, Norris JM, North K, Ogunniyi A, Padmanabhan S, Palmas WR, Palmer ND, Pankow JS, Pedersen NL, Peters A, Peyser PA, Polasek O, Raitakari OT, Renström F, Rice TK, Ridker PM, Robino A, Robinson JG, Rose LM, Rudan I, Sabanayagam C, Salako BL, Sandow K, Schmidt CO, Schreiner PJ, Scott WR, Seshadri S, Sever P, Sitlani CM, Smith JA, Snieder H, Starr JM, Strauch K, Tang H, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, Waldenberger M, Wang L, Wang YX, Wei WB, Williams C, Wilson G, Wojczynski MK, Yao J, Yuan JM, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Chen YI, de Faire U, Deary IJ, Esko T, Farrall M, Forrester T, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Hung YJ, Jonas JB, Kato N, Kooner JS, Laakso M, Lehtimäki T, Liang KW, Magnusson PKE, Newman AB, Oldehinkel AJ, Pereira AC, Redline S, Rettig R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Wu T, Zheng W, Kamatani Y, Laurie CC, Bouchard C, Cooper RS, Evans MK, Gudnason V, Kardia SLR, Kritchevsky SB, Levy D, O'Connell JR, Psaty BM, van Dam RM, Sims M, Arnett DK, Mook-Kanamori DO, Kelly TN, Fox ER, Hayward C, Fornage M, Rotimi CN, Province MA, van Duijn CM, Tai ES, Wong TY, Loos RJF, Reiner AP, Rotter JI, Zhu X, Bierut LJ, Gauderman WJ, Caulfield MJ, Elliott P, Rice K, Munroe PB, Morrison AC, Cupples LA, Rao DC, Chasman DI. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet. 2018 Mar 01; 102(3):375-400.View Related Profiles.

Liu, Ching-Ti
Cupples, L
Seshadri, Sudha

PMID: 29455858.

Charidimou A, Shams S, Romero JR, Ding J, Veltkamp R, Horstmann S, Eiriksdottir G, van Buchem MA, Gudnason V, Himali JJ, Gurol ME, Viswanathan A, Imaizumi T, Vernooij MW, Seshadri S, Greenberg SM, Benavente OR, Launer LJ, Shoamanesh A. Clinical significance of cerebral microbleeds on MRI: A comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1). Int J Stroke. 2018 Jul; 13(5):454-468.View Related Profiles.

Himali, Jayandra
Romero, Jose
Seshadri, Sudha

PMID: 29338604; DOI: 10.1177/1747493017751931;.

Marioni RE, McRae AF, Bressler J, Colicino E, Hannon E, Li S, Prada D, Smith JA, Trevisi L, Tsai PC, Vojinovic D, Simino J, Levy D, Liu C, Mendelson M, Satizabal CL, Yang Q, Jhun MA, Kardia SLR, Zhao W, Bandinelli S, Ferrucci L, Hernandez DG, Singleton AB, Harris SE, Starr JM, Kiel DP, McLean RR, Just AC, Schwartz J, Spiro A, Vokonas P, Amin N, Ikram MA, Uitterlinden AG, van Meurs JBJ, Spector TD, Steves C, Baccarelli AA, Bell JT, van Duijn CM, Fornage M, Hsu YH, Mill J, Mosley TH, Seshadri S, Deary IJ. Meta-analysis of epigenome-wide association studies of cognitive abilities. Mol Psychiatry. 2018 Jan 08.View Related Profiles.

Spiro, Avron
Liu, Chunyu
Satizabal, Claudia
Vokonas, Pantel
Yang, Qiong
Seshadri, Sudha

PMID: 29311653; DOI: 10.1038/s41380-017-0008-y;.

van der Lee SJ, Teunissen CE, Pool R, Shipley MJ, Teumer A, Chouraki V, Melo van Lent D, Tynkkynen J, Fischer K, Hernesniemi J, Haller T, Singh-Manoux A, Verhoeven A, Willemsen G, de Leeuw FA, Wagner H, van Dongen J, Hertel J, Budde K, Willems van Dijk K, Weinhold L, Ikram MA, Pietzner M, Perola M, Wagner M, Friedrich N, Slagboom PE, Scheltens P, Yang Q, Gertzen RE, Egert S, Li S, Hankemeier T, van Beijsterveldt CEM, Vasan RS, Maier W, Peeters CFW, Jörgen Grabe H, Ramirez A, Seshadri S, Metspalu A, Kivimäki M, Salomaa V, Demirkan A, Boomsma DI, van der Flier WM, Amin N, van Duijn CM. Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies. Alzheimers Dement. 2018 Jan 06.View Related Profiles.

Yang, Qiong
Seshadri, Sudha

PMID: 29316447; DOI: 10.1016/j.jalz.2017.11.012;.

Ganguli M, Albanese E, Seshadri S, Bennett DA, Lyketsos C, Kukull WA, Skoog I, Hendrie HC. Population Neuroscience: Dementia Epidemiology Serving Precision Medicine and Population Health. Alzheimer Dis Assoc Disord. 2018 Jan-Mar; 32(1):1-9. PMID: 29319603.

Showing 10 of 321 results. Show More

Weinstein G, Zelber-Sagi S, Preis SR, Beiser AS, DeCarli C, Speliotes EK, Satizabal CL, Vasan RS, Seshadri S. Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study. JAMA Neurol. 2018 Jan 01; 75(1):97-104.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Weinstein, Galit
Preis, Sarah
Seshadri, Sudha
Ramachandran, Vasan

PMID: 29159396.

Sarnowski C, Satizabal CL, DeCarli C, Pitsillides AN, Cupples LA, Vasan RS, Wilson JG, Bis JC, Fornage M, Beiser AS, DeStefano AL, Dupuis J, Seshadri S. Whole genome sequence analyses of brain imaging measures in the Framingham Study. Neurology. 2018 Jan 16; 90(3):e188-e196.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Satizabal, Claudia
Dupuis, Josee
Cupples, L
Yang, Qiong
Seshadri, Sudha
Ramachandran, Vasan

PMID: 29282330.

Adams S, Conner S, Himali JJ, Beiser A, Vasan RS, Seshadri S, Pase MP. Vascular risk factor burden and new-onset depression in the community. Prev Med. 2018 Jun; 111:348-350.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 29197532; DOI: 10.1016/j.ypmed.2017.11.022;.

McGrath ER, Beiser AS, DeCarli C, Plourde KL, Vasan RS, Greenberg SM, Seshadri S. Blood pressure from mid- to late life and risk of incident dementia. Neurology. 2017 Dec 12; 89(24):2447-2454.View Related Profiles.

Beiser, Alexa
Seshadri, Sudha
Ramachandran, Vasan

PMID: 29117954.

Chibnik LB, Wolters FJ, Bäckman K, Beiser A, Berr C, Bis JC, Boerwinkle E, Bos D, Brayne C, Dartigues JF, Darweesh SKL, Debette S, Davis-Plourde KL, Dufouil C, Fornage M, Grasset L, Gudnason V, Hadjichrysanthou C, Helmer C, Ikram MA, Ikram MK, Kern S, Kuller LH, Launer L, Lopez OL, Matthews F, Meirelles O, Mosley T, Ower A, Psaty BM, Satizabal CL, Seshadri S, Skoog I, Stephan BCM, Tzourio C, Waziry R, Wong MM, Zettergren A, Hofman A. Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium. Eur J Epidemiol. 2017 Oct; 32(10):931-938.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Seshadri, Sudha

PMID: 29063414.

Huan T, Chen G, Liu C, Bhattacharya A, Rong J, Chen BH, Seshadri S, Tanriverdi K, Freedman JE, Larson MG, Murabito JM, Levy D. Age-associated microRNA expression in human peripheral blood is associated with all-cause mortality and age-related traits. Aging Cell. 2018 Feb; 17(1).View Related Profiles.

Liu, Chunyu
Murabito, Joanne
Larson, Martin
Seshadri, Sudha

PMID: 29044988.

Beecham GW, Bis JC, Martin ER, Choi SH, DeStefano AL, van Duijn CM, Fornage M, Gabriel SB, Koboldt DC, Larson DE, Naj AC, Psaty BM, Salerno W, Bush WS, Foroud TM, Wijsman E, Farrer LA, Goate A, Haines JL, Pericak-Vance MA, Boerwinkle E, Mayeux R, Seshadri S, Schellenberg G. The Alzheimer's Disease Sequencing Project: Study design and sample selection. Neurol Genet. 2017 Oct; 3(5):e194.View Related Profiles.

DeStefano, Anita
Farrer, Lindsay
Seshadri, Sudha

PMID: 29184913.

Pase MP, Seshadri S. Author response: Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia. Neurology. 2017 Oct 03; 89(14):1532-1533. PMID: 28972109.

Pase MP, Westwood AJ, Beiser A, Jain N, DeCarli C, Himali JJ, Auerbach SH, Seshadri S. Author response: Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia. Neurology. 2017 Oct 03; 89(14):1533.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Auerbach, Sanford
Seshadri, Sudha

PMID: 28972111.

Rannikmäe K, Sivakumaran V, Millar H, Malik R, Anderson CD, Chong M, Dave T, Falcone GJ, Fernandez-Cadenas I, Jimenez-Conde J, Lindgren A, Montaner J, O'Donnell M, Paré G, Radmanesh F, Rost NS, Slowik A, Söderholm M, Traylor M, Pulit SL, Seshadri S, Worrall BB, Woo D, Markus HS, Mitchell BD, Dichgans M, Rosand J, Sudlow CLM. COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls. Neurology. 2017 Oct 24; 89(17):1829-1839. PMID: 28954878.

Lin H, Satizabal C, Xie Z, Yang Q, Huan T, Joehanes R, Wen C, Munson PJ, Beiser A, Levy D, Seshadri S. Whole blood gene expression and white matter Hyperintensities. Mol Neurodegener. 2017 09 18; 12(1):67.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Lin, Honghuang
Yang, Qiong
Seshadri, Sudha

PMID: 28923099.

Gorelick PB, Furie KL, Iadecola C, Smith EE, Waddy SP, Lloyd-Jones DM, Bae HJ, Bauman MA, Dichgans M, Duncan PW, Girgus M, Howard VJ, Lazar RM, Seshadri S, Testai FD, van Gaal S, Yaffe K, Wasiak H, Zerna C. Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association. Stroke. 2017 Oct; 48(10):e284-e303. PMID: 28883125.

Pase MP, Himali JJ, Grima NA, Beiser AS, Satizabal CL, Aparicio HJ, Thomas RJ, Gottlieb DJ, Auerbach SH, Seshadri S. Sleep architecture and the risk of incident dementia in the community. Neurology. 2017 Sep 19; 89(12):1244-1250.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 28835407; DOI: 10.1212/WNL.0000000000004373;.

Cooper LL, Himali JJ, Torjesen A, Tsao CW, Beiser A, Hamburg NM, DeCarli C, Vasan RS, Seshadri S, Pase MP, Mitchell GF. Inter-Relations of Orthostatic Blood Pressure Change, Aortic Stiffness, and Brain Structure and Function in Young Adults. J Am Heart Assoc. 2017 Aug 17; 6(8).View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Hamburg, Naomi
Seshadri, Sudha
Ramachandran, Vasan

PMID: 28862943; DOI: 10.1161/JAHA.117.006206;.

Sánchez-Juan P, Seshadri S. Dynamic measurements of ß-amyloid accumulation: The early effect of APOE. Neurology. 2017 Sep 05; 89(10):986-987. PMID: 28794255.

Pase MP, Himali JJ, Seshadri S, Jacques PF. Response by Pase et al to Letter Regarding Article, "Sweetened Beverages and the Risks of Incident Stroke and Dementia". Stroke. 2017 09; 48(9):e269.View Related Profiles.

Himali, Jayandra
Seshadri, Sudha

PMID: 28784919; DOI: 10.1161/STROKEAHA.117.018603;.

Pase MP, Himali JJ, Beiser A, Seshadri S, Jacques PF. Response by Pase et al to Letters Regarding Article, "Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia. A Prospective Cohort Study". Stroke. 2017 Jul 18.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Seshadri, Sudha

PMID: 28720657; DOI: 10.1161/STROKEAHA.117.018067;.

Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Jr WTL, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sager MA, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Garzia F, Golamaully F, Septier G, Engelborghs S, Vandenberghe R, De Deyn PP, Fernadez CM, Benito YA, Thonberg H, Forsell C, Lilius L, Kinhult-Stählbom A, Kilander L, Brundin R, Concari L, Helisalmi S, Koivisto AM, Haapasalo A, Dermecourt V, Fievet N, Hanon O, Dufouil C, Brice A, Ritchie K, Dubois B, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, Lipton RB, et al. RarView Related Profiles.

Beiser, Alexa
DeStefano, Anita
McKee, Ann
Satizabal, Claudia
Jun, Gyungah
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Himali, Jayandra
Dupuis, Josee
Lunetta, Kathryn
Cupples, L
Farrer, Lindsay
Kowall, Neil
Yang, Qiong
Stern, Robert
Seshadri, Sudha

PMID: 28714976.

Simino J, Wang Z, Bressler J, Chouraki V, Yang Q, Younkin SG, Seshadri S, Fornage M, Boerwinkle E, Mosley TH. Whole exome sequence-based association analyses of plasma amyloid-ß in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study. PLoS One. 2017; 12(7):e0180046.View Related Profiles.

Yang, Qiong
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PMID: 28704393.

Larsson SC, Scott RA, Traylor M, Langenberg CC, Hindy G, Melander O, Orho-Melander M, Seshadri S, Wareham NJ, Markus HS. Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: Mendelian randomization study. Neurology. 2017 Aug 01; 89(5):454-460. PMID: 28667182.

Aparicio HJ, Himali JJ, Beiser AS, Davis-Plourde KL, Vasan RS, Kase CS, Wolf PA, Seshadri S. Overweight, Obesity, and Survival After Stroke in the Framingham Heart Study. J Am Heart Assoc. 2017 Jun 24; 6(6).View Related Profiles.

Beiser, Alexa
Kase, Carlos
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Himali, Jayandra
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PMID: 28647687.

Aparicio HJ, Petrea RE, Massaro JM, Manning WJ, Oyama-Manabe N, Beiser AS, Kase CS, D'Agostino RB, Wolf PA, Vasan RS, DeCarli C, O'Donnell CJ, Seshadri S. Association of descending thoracic aortic plaque with brain atrophy and white matter hyperintensities: The Framingham Heart Study. Atherosclerosis. 2017 Oct; 265:305-311.View Related Profiles.

Beiser, Alexa
Kase, Carlos
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PMID: 28673480.

Huang KL, Marcora E, Pimenova AA, Di Narzo AF, Kapoor M, Jin SC, Harari O, Bertelsen S, Fairfax BP, Czajkowski J, Chouraki V, Grenier-Boley B, Bellenguez C, Deming Y, McKenzie A, Raj T, Renton AE, Budde J, Smith A, Fitzpatrick A, Bis JC, DeStefano A, Adams HHH, Ikram MA, van der Lee S, Del-Aguila JL, Fernandez MV, Ibañez L, Sims R, Escott-Price V, Mayeux R, Haines JL, Farrer LA, Pericak-Vance MA, Lambert JC, van Duijn C, Launer L, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Zhang B, Borecki I, Kauwe JSK, Cruchaga C, Hao K, Goate AM. A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. Nat Neurosci. 2017 Aug; 20(8):1052-1061.View Related Profiles.

DeStefano, Anita
Farrer, Lindsay
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Saber H, Himali JJ, Beiser AS, Shoamanesh A, Pikula A, Roubenoff R, Romero JR, Kase CS, Vasan RS, Seshadri S. Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study. Stroke. 2017 Jul; 48(7):1760-1765.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Himali, Jayandra
Romero, Jose
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Pase MP, Satizabal CL, Seshadri S. Role of Improved Vascular Health in the Declining Incidence of Dementia. Stroke. 2017 07; 48(7):2013-2020.View Related Profiles.

Satizabal, Claudia
Seshadri, Sudha

PMID: 28596460.

Chouraki V, Preis SR, Yang Q, Beiser A, Li S, Larson MG, Weinstein G, Wang TJ, Gerszten RE, Vasan RS, Seshadri S. Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study. Alzheimers Dement. 2017 Dec; 13(12):1327-1336.View Related Profiles.

Beiser, Alexa
Weinstein, Galit
Larson, Martin
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Preis, Sarah
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Ramachandran, Vasan

PMID: 28602601.

Pase MP, Seshadri S, Jacques PF. Response by Pase et al to Letter Regarding Article, "Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study". Stroke. 2017 07; 48(7):e181. PMID: 28583997.

Tan ZS, Spartano NL, Beiser AS, DeCarli C, Auerbach SH, Vasan RS, Seshadri S. Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study. J Gerontol A Biol Sci Med Sci. 2017 Jun 01; 72(6):789-795.View Related Profiles.

Beiser, Alexa
Spartano, Nicole
Auerbach, Sanford
Seshadri, Sudha
Ramachandran, Vasan

PMID: 27422439; DOI: 10.1093/gerona/glw130;.

Wu YT, Beiser AS, Breteler MMB, Fratiglioni L, Helmer C, Hendrie HC, Honda H, Ikram MA, Langa KM, Lobo A, Matthews FE, Ohara T, Pérès K, Qiu C, Seshadri S, Sjölund BM, Skoog I, Brayne C. The changing prevalence and incidence of dementia over time - current evidence. Nat Rev Neurol. 2017 Jun; 13(6):327-339.View Related Profiles.

Beiser, Alexa
Seshadri, Sudha

PMID: 28497805.

Maillard P, Mitchell GF, Himali JJ, Beiser A, Fletcher E, Tsao CW, Pase MP, Satizabal CL, Vasan RS, Seshadri S, DeCarli C. Aortic Stiffness, Increased White Matter Free Water, and Altered Microstructural Integrity: A Continuum of Injury. Stroke. 2017 Jun; 48(6):1567-1573.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 28473633; DOI: 10.1161/STROKEAHA.116.016321;.

Pase MP, Himali JJ, Beiser AS, Aparicio HJ, Satizabal CL, Vasan RS, Seshadri S, Jacques PF. Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study. Stroke. 2017 May; 48(5):1139-1146.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 28428346; DOI: 10.1161/STROKEAHA.116.016027;.

Lubitz SA, Seshadri S, Benjamin EJ. Response by Lubitz et al to Letter Regarding Article, "Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study". Stroke. 2017 06; 48(6):e143.View Related Profiles.

Benjamin, Emelia
Seshadri, Sudha

PMID: 28416627; DOI: 10.1161/STROKEAHA.117.017108;.

Salinas J, Beiser A, Himali JJ, Satizabal CL, Aparicio HJ, Weinstein G, Mateen FJ, Berkman LF, Rosand J, Seshadri S. Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia. Alzheimers Dement (N Y). 2017 Jun; 3(2):229-237.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Weinstein, Galit
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha

PMID: 29067329; DOI: 10.1016/j.trci.2017.03.001;.

Qian J, Wolters FJ, Beiser A, Haan M, Ikram MA, Karlawish J, Langbaum JB, Neuhaus JM, Reiman EM, Roberts JS, Seshadri S, Tariot PN, Woods BM, Betensky RA, Blacker D. APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts. PLoS Med. 2017 Mar; 14(3):e1002254.View Related Profiles.

Beiser, Alexa
Seshadri, Sudha

PMID: 28323826; DOI: 10.1371/journal.pmed.1002254;.

Stefanidou M, Das RR, Beiser AS, Sundar B, Kelly-Hayes M, Kase CS, Devinsky O, Seshadri S, Friedman D. Incidence of seizures following initial ischemic stroke in a community-based cohort: The Framingham Heart Study. Seizure. 2017 Apr; 47:105-110.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Stefanidou, Maria
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Romero JR, Beiser A, Himali JJ, Shoamanesh A, DeCarli C, Seshadri S. Cerebral microbleeds and risk of incident dementia: the Framingham Heart Study. Neurobiol Aging. 2017 Jun; 54:94-99.View Related Profiles.

Beiser, Alexa
Shoamanesh, Ashkan
Himali, Jayandra
Seshadri, Sudha

PMID: 28347929; DOI: 10.1016/j.neurobiolaging.2017.02.018;.

Pase MP, Himali JJ, Jacques PF, DeCarli C, Satizabal CL, Aparicio H, Vasan RS, Beiser AS, Seshadri S. Sugary beverage intake and preclinical Alzheimer's disease in the community. Alzheimers Dement. 2017 Sep; 13(9):955-964.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Aparicio, Hugo
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 28274718; DOI: 10.1016/j.jalz.2017.01.024;.

Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, Yet I, Spector TD, Bell JT, Hannon E, Mill J, Chauhan G, Debette S, Bis JC, Longstreth WT, Ikram MA, Launer LJ, Seshadri S, Hamilton-Bruce MA, Jimenez-Conde J, Cole JW, Schmidt R, Slowik A, Lemmens R, Lindgren A, Melander O, Grewal RP, Sacco RL, Rundek T, Rexrode K, Arnett DK, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Pulit SL, Wong Q, Rich SS, de Bakker PI, McArdle PF, Woo D, Anderson CD, Xu H, Heitsch L, Fornage M, Jern C, Stefansson K, Thorsteinsdottir U, Gretarsdottir S, Lewis CM, Sharma P, Sudlow CL, Rothwell PM, Boncoraglio GB, Thijs V, Levi C, Meschia JF, Rosand J, Kittner SJ, Mitchell BD, Dichgans M, Worrall BB, Markus HS. Genetic variation at 16q24.2 is associated with small vessel stroke. Ann Neurol. 2017 Mar; 81(3):383-394. PMID: 27997041; DOI: 10.1002/ana.24840;.

Westwood AJ, Beiser A, Jain N, Himali JJ, DeCarli C, Auerbach SH, Pase MP, Seshadri S. Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia. Neurology. 2017 Mar 21; 88(12):1172-1179.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Auerbach, Sanford
Seshadri, Sudha

PMID: 28228567; DOI: 10.1212/WNL.0000000000003732;.

Georgakis MK, Synetos A, Mihas C, Karalexi MA, Tousoulis D, Seshadri S, Petridou ET. Left ventricular hypertrophy in association with cognitive impairment: a systematic review and meta-analysis. Hypertens Res. 2017 Jul; 40(7):696-709. PMID: 28202945; DOI: 10.1038/hr.2017.11;.

Dufouil C, Beiser A, McLure LA, Wolf PA, Tzourio C, Howard VJ, Westwood AJ, Himali JJ, Sullivan L, Aparicio HJ, Kelly-Hayes M, Ritchie K, Kase CS, Pikula A, Romero JR, D'Agostino RB, Samieri C, Vasan RS, Chêne G, Howard G, Seshadri S. Revised Framingham Stroke Risk Profile to Reflect Temporal Trends. Circulation. 2017 Mar 21; 135(12):1145-1159.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Aparicio, Hugo
Himali, Jayandra
Romero, Jose
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Ramachandran, Vasan

PMID: 28159800; DOI: 10.1161/CIRCULATIONAHA.115.021275;.

Romero JR, Preis SR, Beiser A, Himali JJ, Shoamanesh A, Wolf PA, Kase CS, Vasan RS, DeCarli C, Seshadri S. Cerebral Microbleeds as Predictors of Mortality: The Framingham Heart Study. Stroke. 2017 Mar; 48(3):781-783.View Related Profiles.

Beiser, Alexa
Shoamanesh, Ashkan
Kase, Carlos
Himali, Jayandra
Wolf, Philip
Preis, Sarah
Seshadri, Sudha
Ramachandran, Vasan

PMID: 28143923; DOI: 10.1161/STROKEAHA.116.015354;.

Hibar DP, Adams HHH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivières S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching CRK, Chouraki V, Cuellar-Partida G, Crivello F, Den Braber A, Doan NT, Ehrlich S, Giddaluru S, Goldman AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Jørgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liewald DCM, Lopez LM, Luciano M, Macare C, Marquand AF, Matarin M, Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Muñoz Maniega S, Nho K, Nugent AC, Nyquist P, Loohuis LMO, Oosterlaan J, Papmeyer M, Pirpamer L, Pütz B, Ramasamy A, Richards JS, Risacher SL, Roiz-Santiañez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Rundek T, Sämann PG, Saremi A, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Trompet S, Vaidya D, Van der Grond J, Van der Lee SJ, Van der Meer D, Van Donkelaar MMJ, Van Eijk KR, Van Erp TGM, Van Rooij D, Walton E, Westlye LT, Whelan CD, Windham BG, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Wolfers T, Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Craen AJM, De Geus EJC, De Jager PL, De Zubicaray GI, Deary IJ, Debette S, DeCarli C, Delanty N, Depondt C, DeStefano A, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Enzinger C, Erk S, Espeseth T, Fedko IO, Fernández G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Fornage M, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Göring HHH, Green RC, Gruber O, Gudnason V, Guelfi S, Håberg AK, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Huentelman M, Hulshoff Pol HE, Ikeda M, Jack CR, Jenkinson M, Johnson R, Jönsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaître H, Liu X, Longo DL, Lopez OL, Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, Mühleisen TW, Müller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nöthen MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BWJH, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt R, Schmidt H, Schofield PR, Sigursson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Toga AW, Traynor BJ, Troncoso J, Tsolaki M, Tzourio C, Uitterlinden AG, Hernández MCV, Van der Brug M, van der Lugt A, van der Wee NJA, Van Haren NEM, van 't Ent D, Van Tol MJ, Vardarajan BN, Vellas B, Veltman DJ, Völzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke RH, Zonderman AB, Martin NG, Van Duijn CM, Wright MJ, Longstreth WT, Schumann G, Grabe HJ, Franke B, Launer LJ, Medland SE, Seshadri S, Thompson PM, Ikram MA. Novel genetic loci associated with hippocampal volume. Nat Commun. 2017 Jan 18; 8:13624.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Satizabal, Claudia
Seshadri, Sudha

PMID: 28098162; DOI: 10.1038/ncomms13624;.

Lubitz SA, Yin X, McManus DD, Weng LC, Aparicio HJ, Walkey AJ, Rafael Romero J, Kase CS, Ellinor PT, Wolf PA, Seshadri S, Benjamin EJ. Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study. Stroke. 2017 Feb; 48(2):490-492.View Related Profiles.

Walkey, Allan
Kase, Carlos
Benjamin, Emelia
Aparicio, Hugo
Wolf, Philip
Seshadri, Sudha

PMID: 28082669; DOI: 10.1161/STROKEAHA.116.015071;.

Weinstein G, Preis SR, Beiser AS, Kaess B, Chen TC, Satizabal C, Rahman F, Benjamin EJ, Vasan RS, Seshadri S. Clinical and Environmental Correlates of Serum BDNF: A Descriptive Study with Plausible Implications for AD Research. Curr Alzheimer Res. 2017; 14(7):722-730.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Benjamin, Emelia
Weinstein, Galit
Preis, Sarah
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Ramachandran, Vasan

PMID: 28164772; DOI: 10.2174/1567205014666170203094520;.

Adams SL, Benayoun L, Tilton K, Chavez OR, Himali JJ, Blusztajn JK, Seshadri S, Delalle I. Methionine Sulfoxide Reductase-B3 (MsrB3) Protein Associates with Synaptic Vesicles and its Expression Changes in the Hippocampi of Alzheimer's Disease Patients. J Alzheimers Dis. 2017; 60(1):43-56.View Related Profiles.

Delalle, Ivana
Blusztajn, Jan
Himali, Jayandra
Chavez, Olivia
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PMID: 28777754.

Lioutas VA, Beiser A, Himali J, Aparicio H, Romero JR, DeCarli C, Seshadri S. Lacunar Infarcts and Intracerebral Hemorrhage Differences: A Nested Case-Control Analysis in the FHS (Framingham Heart Study). Stroke. 2017 Feb; 48(2):486-489.View Related Profiles.

Beiser, Alexa
Aparicio, Hugo
Himali, Jayandra
Romero, Jose
Seshadri, Sudha

PMID: 28008091; DOI: 10.1161/STROKEAHA.116.014839;.

Snyder HM, Ahles T, Calderwood S, Carrillo MC, Chen H, Chang CH, Craft S, De Jager P, Driver JA, Fillit H, Knopman D, Lotze M, Tierney MC, Petanceska S, Saykin A, Seshadri S, Shineman D, Ganguli M. Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association & Alzheimer's Drug Discovery Foundation. Alzheimers Dement. 2017 Mar; 13(3):267-273. PMID: 27998721; DOI: 10.1016/j.jalz.2016.11.002;.

Smith EE, Saposnik G, Biessels GJ, Doubal FN, Fornage M, Gorelick PB, Greenberg SM, Higashida RT, Kasner SE, Seshadri S. Prevention of Stroke in Patients With Silent Cerebrovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2017 Feb; 48(2):e44-e71. PMID: 27980126; DOI: 10.1161/STR.0000000000000116;.

Chauhan G, Debette S. Genetic Risk Factors for Ischemic and Hemorrhagic Stroke. Curr Cardiol Rep. 2016 Dec; 18(12):124. PMID: 27796860.

Jakobsdottir J, van der Lee SJ, Bis JC, Chouraki V, Li-Kroeger D, Yamamoto S, Grove ML, Naj A, Vronskaya M, Salazar JL, DeStefano AL, Brody JA, Smith AV, Amin N, Sims R, Ibrahim-Verbaas CA, Choi SH, Satizabal CL, Lopez OL, Beiser A, Ikram MA, Garcia ME, Hayward C, Varga TV, Ripatti S, Franks PW, Hallmans G, Rolandsson O, Jansson JH, Porteous DJ, Salomaa V, Eiriksdottir G, Rice KM, Bellen HJ, Levy D, Uitterlinden AG, Emilsson V, Rotter JI, Aspelund T, O'Donnell CJ, Fitzpatrick AL, Launer LJ, Hofman A, Wang LS, Williams J, Schellenberg GD, Boerwinkle E, Psaty BM, Seshadri S, Shulman JM, Gudnason V, van Duijn CM. Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease. PLoS Genet. 2016 Oct; 12(10):e1006327.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Satizabal, Claudia
Seshadri, Sudha

PMID: 27764101; DOI: 10.1371/journal.pgen.1006327;.

Rahman F, Himali JJ, Yin X, Beiser AS, Ellinor PT, Lubitz SA, Vasan RS, Magnani JW, McManus DD, Seshadri S, Benjamin EJ. Serum brain-derived neurotrophic factor and risk of atrial fibrillation. Am Heart J. 2017 Jan; 183:69-73.View Related Profiles.

Beiser, Alexa
Benjamin, Emelia
Himali, Jayandra
Seshadri, Sudha
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PMID: 27979044; DOI: 10.1016/j.ahj.2016.07.027;.

Iadecola C, Yaffe K, Biller J, Bratzke LC, Faraci FM, Gorelick PB, Gulati M, Kamel H, Knopman DS, Launer LJ, Saczynski JS, Seshadri S, Zeki Al Hazzouri A. Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association. Hypertension. 2016 Dec; 68(6):e67-e94. PMID: 27977393.

Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Rentería ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivières S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beiser A, Bernard M, Bis JC, Blanken LM, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chauhan G, Chen Q, Ching CR, Cuellar-Partida G, Braber AD, Doan NT, Ehrlich S, Filippi I, Ge T, Giddaluru S, Goldman AL, Gottesman RF, Greven CU, Grimm O, Griswold ME, Guadalupe T, Hass J, Haukvik UK, Hilal S, Hofer E, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liao J, Liewald DC, Lopez LM, Luciano M, Macare C, Marquand A, Matarin M, Mather KA, Mattheisen M, Mazoyer B, McKay DR, McWhirter R, Milaneschi Y, Mirza-Schreiber N, Muetzel RL, Maniega SM, Nho K, Nugent AC, Loohuis LM, Oosterlaan J, Papmeyer M, Pappa I, Pirpamer L, Pudas S, Pütz B, Rajan KB, Ramasamy A, Richards JS, Risacher SL, Roiz-Santiañez R, Rommelse N, Rose EJ, Royle NA, Rundek T, Sämann PG, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Thomson R, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Vaidya D, Van der Grond J, Van der Meer D, Van Donkelaar MM, Van Eijk KR, Van Erp TG, Van Rooij D, Walton E, Westlye LT, Whelan CD, Windham BG, Winkler AM, Woldehawariat G, Wolf C, Wolfers T, Xu B, Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Aggarwal NT, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Chen C, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Geus EJ, De Jager PL, de Zubicaray GI, Delanty N, Depondt C, DeStefano AL, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Erk S, Espeseth T, Evans DA, Fedko IO, Fernández G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Göring HH, Grabe HJ, Green RC, Gruber O, Gudnason V, Guelfi S, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Pol HE, Ikeda M, Ikram MK, Jack CR, Jenkinson M, Johnson R, Jönsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaître H, Liu X, Longo DL, Longstreth WT, Lopez OL, Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon KL, McMahon FJ, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, Mühleisen TW, Müller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nöthen MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BW, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt R, Schofield PR, Sigurdsson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Srikanth V, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Tiemeier H, Toga AW, Traynor BJ, Troncoso J, Turner JA, Tzourio C, Uitterlinden AG, Hernández MC, Van der Brug M, Van der Lugt A, Van der Wee NJ, Van Duijn CM, Van Haren NE, Van T Ent D, Van Tol MJ, Vardarajan BN, Veltman DJ, Vernooij MW, Völzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke HR, Zonderman AB, Deary IJ, DeCarli C, Schmidt H, Martin NG, De Craen AJ, Wright MJ, Launer LJ, Schumann G, Fornage M, Franke B, Debette S, Medland SE, Ikram MA, Thompson PM. Novel genetic loci underlying human iView Related Profiles.

Beiser, Alexa
DeStefano, Anita
Satizabal, Claudia
Seshadri, Sudha

PMID: 27694991; DOI: 10.1038/nn.4398;.

Carrera C, Jiménez-Conde J, Derdak S, Rabionet K, Vives-Bauzá C, Soriano-Tárrega C, Giralt-Steinhauer E, Mola-Caminal M, Diaz-Navarro RM, Tur S, Muiño E, Gallego-Fabrega C, Beltran S, Roquer J, Ruiz A, Sotolongo-Grau O, Krupinski J, Lee JM, Cruchaga C, Delgado P, Malik R, Worrall BB, Seshadri S, Montaner J, Fernández-Cadenas I. Whole exome sequencing analysis reveals TRPV3 as a risk factor for cardioembolic stroke. Thromb Haemost. 2016 Nov 30; 116(6):1165-1171. PMID: 27604134.

Shoamanesh A, Preis SR, Beiser AS, Kase CS, Wolf PA, Vasan RS, Benjamin EJ, Seshadri S, Romero JR. Circulating biomarkers and incident ischemic stroke in the Framingham Offspring Study. Neurology. 2016 Sep 20; 87(12):1206-11.View Related Profiles.

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Shoamanesh, Ashkan
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PMID: 27558379; DOI: 10.1212/WNL.0000000000003115;.

Pase MP, Beiser A, Himali JJ, Tsao C, Satizabal CL, Vasan RS, Seshadri S, Mitchell GF. Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia. Stroke. 2016 Sep; 47(9):2256-61.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Himali, Jayandra
Seshadri, Sudha
Ramachandran, Vasan

PMID: 27491735; PMCID: PMC4995162; DOI: 10.1161/STROKEAHA.116.013508;.

METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research. Alzheimers Dement. 2016 Dec; 12(12):1235-1249. PMID: 27490018; DOI: 10.1016/j.jalz.2016.06.004;.

Camargo EC, Weinstein G, Beiser AS, Tan ZS, DeCarli C, Kelly-Hayes M, Kase C, Murabito JM, Seshadri S. Association of Physical Function with Clinical and Subclinical Brain Disease: The Framingham Offspring Study. J Alzheimers Dis. 2016 07 14; 53(4):1597-608.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Weinstein, Galit
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PMID: 27540965; DOI: 10.3233/JAD-160229;.

Weinstein G, Beiser AS, Preis SR, Courchesne P, Chouraki V, Levy D, Seshadri S. Plasma clusterin levels and risk of dementia, Alzheimer's disease, and stroke. Alzheimers Dement (Amst). 2016; 3:103-9.View Related Profiles.

Beiser, Alexa
Weinstein, Galit
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PMID: 27453932; DOI: 10.1016/j.dadm.2016.06.005;.

Satizabal C, Beiser AS, Seshadri S. Incidence of Dementia over Three Decades in the Framingham Heart Study. N Engl J Med. 2016 Jul 7; 375(1):93-4.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Seshadri, Sudha

PMID: 27406362; DOI: 10.1056/NEJMc1604823;.

Bangen KJ, Himali JJ, Beiser AS, Nation DA, Libon DJ, Fox CS, Seshadri S, Wolf PA, McKee AC, Au R, Delano-Wood L. Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer's Disease Pathology. J Alzheimers Dis. 2016 07 06; 53(4):1553-62.View Related Profiles.

Beiser, Alexa
McKee, Ann
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 27392855; DOI: 10.3233/JAD-160163;.

Hankee LD, Preis SR, Piers RJ, Beiser AS, Devine SA, Liu Y, Seshadri S, Wolf PA, Au R. Population Normative Data for the CERAD Word List and Victoria Stroop Test in Younger- and Middle-Aged Adults: Cross-Sectional Analyses from the Framingham Heart Study. Exp Aging Res. 2016 Jul-Sep; 42(4):315-28.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
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PMID: 27410241; PMCID: PMC4946576; DOI: 10.1080/0361073X.2016.1191838;.

Nation DA, Preis SR, Beiser A, Bangen KJ, Delano-Wood L, Lamar M, Libon DJ, Seshadri S, Wolf PA, Au R. Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-e4. Alzheimer Dis Assoc Disord. 2016 Jul-Sep; 30(3):210-5.View Related Profiles.

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Wolf, Philip
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PMID: 27556935; PMCID: PMC4999260; DOI: 10.1097/WAD.0000000000000127;.

Kaess BM, Preis SR, Beiser A, Sawyer DB, Chen TC, Seshadri S, Vasan RS. Circulating vascular endothelial growth factor and the risk of cardiovascular events. Heart. 2016 Dec 01; 102(23):1898-1901.View Related Profiles.

Beiser, Alexa
Kaess, Bernhard
Preis, Sarah
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PMID: 27354275; DOI: 10.1136/heartjnl-2015-309155;.

Adams SL, Tilton K, Kozubek JA, Seshadri S, Delalle I. Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology. J Neuropathol Exp Neurol. 2016 Aug; 75(8):779-790.View Related Profiles.

Delalle, Ivana
Seshadri, Sudha

PMID: 27346750.

Matteini AM, Tanaka T, Karasik D, Atzmon G, Chou WC, Eicher JD, Johnson AD, Arnold AM, Callisaya ML, Davies G, Evans DS, Holtfreter B, Lohman K, Lunetta KL, Mangino M, Smith AV, Smith JA, Teumer A, Yu L, Arking DE, Buchman AS, Chibinik LB, De Jager PL, Evans DA, Faul JD, Garcia ME, Gillham-Nasenya I, Gudnason V, Hofman A, Hsu YH, Ittermann T, Lahousse L, Liewald DC, Liu Y, Lopez L, Rivadeneira F, Rotter JI, Siggeirsdottir K, Starr JM, Thomson R, Tranah GJ, Uitterlinden AG, Völker U, Völzke H, Weir DR, Yaffe K, Zhao W, Zhuang WV, Zmuda JM, Bennett DA, Cummings SR, Deary IJ, Ferrucci L, Harris TB, Kardia SL, Kocher T, Kritchevsky SB, Psaty BM, Seshadri S, Spector TD, Srikanth VK, Windham BG, Zillikens MC, Newman AB, Walston JD, Kiel DP, Murabito JM. GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Aging Cell. 2016 Oct; 15(5):792-800.View Related Profiles.

Murabito, Joanne
Lunetta, Kathryn
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PMID: 27325353; DOI: 10.1111/acel.12468;.

Teumer A, Qi Q, Nethander M, Aschard H, Bandinelli S, Beekman M, Berndt SI, Bidlingmaier M, Broer L, Cappola A, Ceda GP, Chanock S, Chen MH, Chen TC, Chen YD, Chung J, Del Greco Miglianico F, Eriksson J, Ferrucci L, Friedrich N, Gnewuch C, Goodarzi MO, Grarup N, Guo T, Hammer E, Hayes RB, Hicks AA, Hofman A, Houwing-Duistermaat JJ, Hu F, Hunter DJ, Husemoen LL, Isaacs A, Jacobs KB, Janssen JA, Jansson JO, Jehmlich N, Johnson S, Juul A, Karlsson M, Kilpelainen TO, Kovacs P, Kraft P, Li C, Linneberg A, Liu Y, Loos RJ, Lorentzon M, Lu Y, Maggio M, Magi R, Meigs J, Mellström D, Nauck M, Newman AB, Pollak MN, Pramstaller PP, Prokopenko I, Psaty BM, Reincke M, Rimm EB, Rotter JI, Saint Pierre A, Schurmann C, Seshadri S, Sjögren K, Slagboom PE, Strickler HD, Stumvoll M, Suh Y, Sun Q, Zhang C, Svensson J, Tanaka T, Tare A, Tönjes A, Uh HW, van Duijn CM, van Heemst D, Vandenput L, Vasan RS, Völker U, Willems SM, Ohlsson C, Wallaschofski H, Kaplan RC. Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell. 2016 Oct; 15(5):811-24.View Related Profiles.

Seshadri, Sudha
Ramachandran, Vasan

PMID: 27329260; DOI: 10.1111/acel.12490;.

Chouraki V, Reitz C, Maury F, Bis JC, Bellenguez C, Yu L, Jakobsdottir J, Mukherjee S, Adams HH, Choi SH, Larson EB, Fitzpatrick A, Uitterlinden AG, de Jager PL, Hofman A, Gudnason V, Vardarajan B, Ibrahim-Verbaas C, van der Lee SJ, Lopez O, Dartigues JF, Berr C, Amouyel P, Bennett DA, van Duijn C, DeStefano AL, Launer LJ, Ikram MA, Crane PK, Lambert JC, Mayeux R, Seshadri S. Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease. J Alzheimers Dis. 2016 Jun 18; 53(3):921-32.View Related Profiles.

DeStefano, Anita
Seshadri, Sudha

PMID: 27340842; PMCID: PMC5036102; DOI: 10.3233/JAD-150749;.

De Guio F, Jouvent E, Biessels GJ, Black SE, Brayne C, Chen C, Cordonnier C, De Leeuw FE, Dichgans M, Doubal F, Duering M, Dufouil C, Duzel E, Fazekas F, Hachinski V, Ikram MA, Linn J, Matthews PM, Mazoyer B, Mok V, Norrving B, O'Brien JT, Pantoni L, Ropele S, Sachdev P, Schmidt R, Seshadri S, Smith EE, Sposato LA, Stephan B, Swartz RH, Tzourio C, van Buchem M, van der Lugt A, van Oostenbrugge R, Vernooij MW, Viswanathan A, Werring D, Wollenweber F, Wardlaw JM, Chabriat H. Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease. J Cereb Blood Flow Metab. 2016 Aug; 36(8):1319-37. PMID: 27170700; PMCID: PMC4976752; DOI: 10.1177/0271678X16647396;.

Kim EJ, Yin X, Fontes JD, Magnani JW, Lubitz SA, McManus DD, Seshadri S, Vasan RS, Ellinor PT, Larson MG, Benjamin EJ, Rienstra M. Atrial fibrillation without comorbidities: Prevalence, incidence and prognosis (from the Framingham Heart Study). Am Heart J. 2016 Jul; 177:138-44.View Related Profiles.

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Larson, Martin
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PMID: 27297859; PMCID: PMC4908973; DOI: 10.1016/j.ahj.2016.03.023;.

Pase MP, Beiser A, Enserro D, Xanthakis V, Aparicio H, Satizabal CL, Himali JJ, Kase CS, Vasan RS, DeCarli C, Seshadri S. Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia. Stroke. 2016 May; 47(5):1201-6.View Related Profiles.

Beiser, Alexa
Kase, Carlos
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PMID: 27073239; PMCID: PMC5006676; DOI: 10.1161/STROKEAHA.115.012608;.

Salinas J, Beiser A, Himali JJ, Rosand J, Seshadri S, Dunn EC. Factors Associated With New-Onset Depression After Stroke. J Neuropsychiatry Clin Neurosci. 2016 Apr 08; appineuropsych15110388.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
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PMID: 27056020; DOI: 10.1176/appi.neuropsych.15110388;.

Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. Lancet Neurol. 2016 06; 15(7):695-707.View Related Profiles.

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PMID: 27068588; PMCID: PMC4943223; DOI: 10.1016/S1474-4422(16)00102-2;.

Therkelsen KE, Preis SR, Beiser A, DeCarli C, Seshadri S, Wolf P, Au R, Fox CS. Neck Circumference, Brain Imaging Measures, and Neuropsychological Testing Measures. J Stroke Cerebrovasc Dis. 2016 Jul; 25(7):1570-81.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
Preis, Sarah
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PMID: 27056441; DOI: 10.1016/j.jstrokecerebrovasdis.2016.02.016;.

Jak AJ, Preis SR, Beiser AS, Seshadri S, Wolf PA, Bondi MW, Au R. Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study. J Int Neuropsychol Soc. 2016 Oct; 22(9):937-943.View Related Profiles.

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Wolf, Philip
Au, Rhoda
Preis, Sarah
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PMID: 27029348.

Romero JR, Preis SR, Beiser A, DeCarli C, D'Agostino RB, Wolf PA, Vasan RS, Polak JF, Seshadri S. Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study. J Am Heart Assoc. 2016 Mar 18; 5(3):e002377.View Related Profiles.

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Wolf, Philip
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PMID: 26994127; PMCID: PMC4943235; DOI: 10.1161/JAHA.115.002377;.

Maillard P, Mitchell GF, Himali JJ, Beiser A, Tsao CW, Pase MP, Satizabal CL, Vasan RS, Seshadri S, DeCarli C. Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study. Stroke. 2016 Apr; 47(4):1030-6.View Related Profiles.

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Satizabal, Claudia
Himali, Jayandra
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Ramachandran, Vasan

PMID: 26965846; PMCID: PMC4811686; DOI: 10.1161/STROKEAHA.116.012949;.

Malik R, Traylor M, Pulit SL, Bevan S, Hopewell JC, Holliday EG, Zhao W, Abrantes P, Amouyel P, Attia JR, Battey TW, Berger K, Boncoraglio GB, Chauhan G, Cheng YC, Chen WM, Clarke R, Cotlarciuc I, Debette S, Falcone GJ, Ferro JM, Gamble DM, Ilinca A, Kittner SJ, Kourkoulis CE, Lemmens R, Levi CR, Lichtner P, Lindgren A, Liu J, Meschia JF, Mitchell BD, Oliveira SA, Pera J, Reiner AP, Rothwell PM, Sharma P, Slowik A, Sudlow CL, Tatlisumak T, Thijs V, Vicente AM, Woo D, Seshadri S, Saleheen D, Rosand J, Markus HS, Worrall BB, Dichgans M. Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. Neurology. 2016 Mar 29; 86(13):1217-26. PMID: 26935894; PMCID: PMC4818561; DOI: 10.1212/WNL.0000000000002528;.

Gupta A, Giambrone AE, Gialdini G, Finn C, Delgado D, Gutierrez J, Wright C, Beiser AS, Seshadri S, Pandya A, Kamel H. Silent Brain Infarction and Risk of Future Stroke: A Systematic Review and Meta-Analysis. Stroke. 2016 Mar; 47(3):719-25.View Related Profiles.

Beiser, Alexa
Seshadri, Sudha

PMID: 26888534; PMCID: PMC4766016; DOI: 10.1161/STROKEAHA.115.011889;.

Choi SH, Ruggiero D, Sorice R, Song C, Nutile T, Vernon Smith A, Concas MP, Traglia M, Barbieri C, Ndiaye NC, Stathopoulou MG, Lagou V, Maestrale GB, Sala C, Debette S, Kovacs P, Lind L, Lamont J, Fitzgerald P, Tönjes A, Gudnason V, Toniolo D, Pirastu M, Bellenguez C, Vasan RS, Ingelsson E, Leutenegger AL, Johnson AD, DeStefano AL, Visvikis-Siest S, Seshadri S, Ciullo M. Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies. PLoS Genet. 2016 Feb; 12(2):e1005874.View Related Profiles.

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Seshadri, Sudha
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PMID: 26910538; PMCID: PMC4766012; DOI: 10.1371/journal.pgen.1005874;.

Traylor M, Adib-Samii P, Harold D, Dichgans M, Williams J, Lewis CM, Markus HS. Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease. Ann Neurol. 2016 Feb 23. PMID: 26913989; DOI: 10.1002/ana.24621;.

Satizabal CL, Beiser AS, Chouraki V, Chêne G, Dufouil C, Seshadri S. Incidence of Dementia over Three Decades in the Framingham Heart Study. N Engl J Med. 2016 Feb 11; 374(6):523-32.View Related Profiles.

Beiser, Alexa
Satizabal, Claudia
Seshadri, Sudha

PMID: 26863354; PMCID: PMC4943081; DOI: 10.1056/NEJMoa1504327;.

Spartano NL, Himali JJ, Beiser AS, Lewis GD, DeCarli C, Vasan RS, Seshadri S. Midlife exercise blood pressure, heart rate, and fitness relate to brain volume 2 decades later. Neurology. 2016 Apr 5; 86(14):1313-9.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
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PMID: 26865519; PMCID: PMC4826343; DOI: 10.1212/WNL.0000000000002415;.

Tsao CW, Himali JJ, Beiser AS, Larson MG, DeCarli C, Vasan RS, Mitchell GF, Seshadri S. Association of arterial stiffness with progression of subclinical brain and cognitive disease. Neurology. 2016 Feb 16; 86(7):619-26.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Larson, Martin
Seshadri, Sudha
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PMID: 26791155; PMCID: PMC4762417; DOI: 10.1212/WNL.0000000000002368;.

Pase MP, Himali JJ, Mitchell GF, Beiser A, Maillard P, Tsao C, Larson MG, DeCarli C, Vasan RS, Seshadri S. Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle-Aged Adults: The Framingham Third Generation Cohort Study. Hypertension. 2016 Mar; 67(3):513-9.View Related Profiles.

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PMID: 26754644; PMCID: PMC4752398; DOI: 10.1161/HYPERTENSIONAHA.115.06610;.

Freudenberger P, Petrovic K, Sen A, Töglhofer AM, Fixa A, Hofer E, Perl S, Zweiker R, Seshadri S, Schmidt R, Schmidt H. Fitness and cognition in the elderly: The Austrian Stroke Prevention Study. Neurology. 2016 Feb 2; 86(5):418-24. PMID: 26740674; PMCID: PMC4773949; DOI: 10.1212/WNL.0000000000002329;.

Cheng YC, Stanne TM, Giese AK, Ho WK, Traylor M, Amouyel P, Holliday EG, Malik R, Xu H, Kittner SJ, Cole JW, O'Connell JR, Danesh J, Rasheed A, Zhao W, Engelter S, Grond-Ginsbach C, Kamatani Y, Lathrop M, Leys D, Thijs V, Metso TM, Tatlisumak T, Pezzini A, Parati EA, Norrving B, Bevan S, Rothwell PM, Sudlow C, Slowik A, Lindgren A, Walters MR, Jannes J, Shen J, Crosslin D, Doheny K, Laurie CC, Kanse SM, Bis JC, Fornage M, Mosley TH, Hopewell JC, Strauch K, Müller-Nurasyid M, Gieger C, Waldenberger M, Peters A, Meisinger C, Ikram MA, Longstreth WT, Meschia JF, Seshadri S, Sharma P, Worrall B, Jern C, Levi C, Dichgans M, Boncoraglio GB, Markus HS, Debette S, Rolfs A, Saleheen D, Mitchell BD. Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2. Stroke. 2016 Feb; 47(2):307-16. PMID: 26732560; PMCID: PMC4729659; DOI: 10.1161/STROKEAHA.115.011328;.

Karakis I, Pase MP, Beiser A, Booth SL, Jacques PF, Rogers G, DeCarli C, Vasan RS, Wang TJ, Himali JJ, Annweiler C, Seshadri S. Association of Serum Vitamin D with the Risk of Incident Dementia and Subclinical Indices of Brain Aging: The Framingham Heart Study. J Alzheimers Dis. 2016; 51(2):451-61.View Related Profiles.

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PMID: 26890771; PMCID: PMC4911705; DOI: 10.3233/JAD-150991;.

Williams SR, Hsu FC, Keene KL, Chen WM, Nelson S, Southerland AM, Madden EB, Coull B, Gogarten SM, Furie KL, Dzhivhuho G, Rowles JL, Mehndiratta P, Malik R, Dupuis J, Lin H, Seshadri S, Rich SS, Sale MM, Worrall BB. Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke. Neurology. 2016 Jan 26; 86(4):351-9.View Related Profiles.

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Harris SE, Malik R, Marioni R, Campbell A, Seshadri S, Worrall BB, Sudlow CL, Hayward C, Bastin ME, Starr JM, Porteous DJ, Wardlaw JM, Deary IJ. Polygenic risk of ischemic stroke is associated with cognitive ability. Neurology. 2016 Feb 16; 86(7):611-8.View Related Profiles.

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Nayor M, Enserro DM, Beiser AS, Cheng S, DeCarli C, Vasan RS, Seshadri S. Association of Exhaled Carbon Monoxide With Stroke Incidence and Subclinical Vascular Brain Injury: Framingham Heart Study. Stroke. 2016 Feb; 47(2):383-9.View Related Profiles.

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PMID: 26696648; PMCID: PMC4729607; DOI: 10.1161/STROKEAHA.115.010405;.

Chatterjee S, Peters SA, Woodward M, Mejia Arango S, Batty GD, Beckett N, Beiser A, Borenstein AR, Crane PK, Haan M, Hassing LB, Hayden KM, Kiyohara Y, Larson EB, Li CY, Ninomiya T, Ohara T, Peters R, Russ TC, Seshadri S, Strand BH, Walker R, Xu W, Huxley RR. Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia. Diabetes Care. 2016 Feb; 39(2):300-7.View Related Profiles.

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PMID: 26681727; PMCID: PMC4722942; DOI: 10.2337/dc15-1588;.

Martinez-Ramirez S, Romero JR, Shoamanesh A, McKee AC, Van Etten E, Pontes-Neto O, Macklin EA, Ayres A, Auriel E, Himali JJ, Beiser AS, DeCarli C, Stein TD, Alvarez VE, Frosch MP, Rosand J, Greenberg SM, Gurol ME, Seshadri S, Viswanathan A. Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage. Alzheimers Dement. 2015 Dec; 11(12):1480-8.View Related Profiles.

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PMID: 26079413; PMCID: PMC4677060; DOI: 10.1016/j.jalz.2015.04.009;.

Xing C, Huang J, Hsu YH, DeStefano AL, Heard-Costa NL, Wolf PA, Seshadri S, Kiel DP, Cupples LA, Dupuis J. Evaluation of power of the Illumina HumanOmni5M-4v1 BeadChip to detect risk variants for human complex diseases. Eur J Hum Genet. 2016 Jul; 24(7):1029-34.View Related Profiles.

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PMID: 26577045; DOI: 10.1038/ejhg.2015.244;.

Seshadri S, Moonis M. Dipping to clear amyloid: Cerebrovascular reactivity and neurodegeneration--cause or effect? Neurology. 2015 Dec 1; 85(22):1918-9. PMID: 26537050; DOI: 10.1212/WNL.0000000000002177;.

Pase MP, Beiser A, Aparicio H, DeCarli C, Vasan RS, Murabito J, Seshadri S. Interarm differences in systolic blood pressure and the risk of dementia and subclinical brain injury. Alzheimers Dement. 2016 Apr; 12(4):438-45.View Related Profiles.

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PMID: 26542262; PMCID: PMC4841714; DOI: 10.1016/j.jalz.2015.09.006;.

Adams HH, Hilal S, Schwingenschuh P, Wittfeld K, van der Lee SJ, DeCarli C, Vernooij MW, Katschnig-Winter P, Habes M, Chen C, Seshadri S, van Duijn CM, Ikram MK, Grabe HJ, Schmidt R, Ikram MA. A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium. Alzheimers Dement (Amst). 2015 Dec; 1(4):513-20. PMID: 27239529; DOI: 10.1016/j.dadm.2015.10.004;.

Escott-Price V, Sims R, Bannister C, Harold D, Vronskaya M, Majounie E, Badarinarayan N, Morgan K, Passmore P, Holmes C, Powell J, Brayne C, Gill M, Mead S, Goate A, Cruchaga C, Lambert JC, van Duijn C, Maier W, Ramirez A, Holmans P, Jones L, Hardy J, Seshadri S, Schellenberg GD, Amouyel P, Williams J. Common polygenic variation enhances risk prediction for Alzheimer's disease. Brain. 2015 Dec; 138(Pt 12):3673-84. PMID: 26490334; DOI: 10.1093/brain/awv268;.

Knopman DS, Beiser A, Machulda MM, Fields J, Roberts RO, Pankratz VS, Aakre J, Cha RH, Rocca WA, Mielke MM, Boeve BF, Devine S, Ivnik RJ, Au R, Auerbach S, Wolf PA, Seshadri S, Petersen RC. Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging. Neurology. 2015 Nov 10; 85(19):1712-21.View Related Profiles.

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PMID: 26453643; PMCID: PMC4653114; DOI: 10.1212/WNL.0000000000002100;.

Hofer E, Cavalieri M, Bis JC, DeCarli C, Fornage M, Sigurdsson S, Srikanth V, Trompet S, Verhaaren BF, Wolf C, Yang Q, Adams HH, Amouyel P, Beiser A, Buckley BM, Callisaya M, Chauhan G, de Craen AJ, Dufouil C, van Duijn CM, Ford I, Freudenberger P, Gottesman RF, Gudnason V, Heiss G, Hofman A, Lumley T, Martinez O, Mazoyer B, Moran C, Niessen WJ, Phan T, Psaty BM, Satizabal CL, Sattar N, Schilling S, Shibata DK, Slagboom PE, Smith A, Stott DJ, Taylor KD, Thomson R, Töglhofer AM, Tzourio C, van Buchem M, Wang J, Westendorp RG, Windham BG, Vernooij MW, Zijdenbos A, Beare R, Debette S, Ikram MA, Jukema JW, Launer LJ, Longstreth WT, Mosley TH, Seshadri S, Schmidt H, Schmidt R. White Matter Lesion Progression: Genome-Wide Search for Genetic Influences. Stroke. 2015 Nov; 46(11):3048-57.View Related Profiles.

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PMID: 26451028; PMCID: PMC4749149; DOI: 10.1161/STROKEAHA.115.009252;.

Luciano M, Marioni RE, Valdés Hernández M, Muñoz Maniega S, Hamilton IF, Royle NA, Chauhan G, Bis JC, Debette S, DeCarli C, Fornage M, Schmidt R, Ikram MA, Launer LJ, Seshadri S, Bastin ME, Porteous DJ, Wardlaw J, Deary IJ. Structural Brain MRI Trait Polygenic Score Prediction of Cognitive Abilities. Twin Res Hum Genet. 2015 Dec; 18(6):738-45. PMID: 26427786; PMCID: PMC4747328; DOI: 10.1017/thg.2015.71;.

Olson NC, Butenas S, Lange LA, Lange EM, Cushman M, Jenny NS, Walston J, Souto JC, Soria JM, Chauhan G, Debette S, Longstreth WT, Seshadri S, Reiner AP, Tracy RP. Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study. J Thromb Haemost. 2015 Oct; 13(10):1867-77. PMID: 26286125; PMCID: PMC4946166; DOI: 10.1111/jth.13111;.

Saber H, Himali JJ, Shoamanesh A, Beiser A, Pikula A, Harris TB, Roubenoff R, Romero JR, Kase CS, Vasan RS, Seshadri S. Serum Leptin Levels and the Risk of Stroke: The Framingham Study. Stroke. 2015 Oct; 46(10):2881-5.View Related Profiles.

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PMID: 26337973; PMCID: PMC4589501; DOI: 10.1161/STROKEAHA.115.009463;.

Andersson C, Preis SR, Beiser A, DeCarli C, Wollert KC, Wang TJ, Januzzi JL, Vasan RS, Seshadri S. Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke. Stroke. 2015 Sep; 46(9):2568-75.View Related Profiles.

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PMID: 26219649; PMCID: PMC4550531; DOI: 10.1161/STROKEAHA.115.009026;.

Rahman F, Wang N, Yin X, Ellinor PT, Lubitz SA, LeLorier PA, McManus DD, Sullivan LM, Seshadri S, Vasan RS, Benjamin EJ, Magnani JW. Atrial flutter: Clinical risk factors and adverse outcomes in the Framingham Heart Study. Heart Rhythm. 2016 Jan; 13(1):233-40.View Related Profiles.

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PMID: 26226213; PMCID: PMC4698205; DOI: 10.1016/j.hrthm.2015.07.031;.

Hanscombe KB, Traylor M, Hysi PG, Bevan S, Dichgans M, Rothwell PM, Worrall BB, Seshadri S, Sudlow C, Williams FM, Markus HS, Lewis CM. Genetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke. Stroke. 2015 Aug; 46(8):2069-74. PMID: 26159793; PMCID: PMC4512747; DOI: 10.1161/STROKEAHA.115.009387;.

Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C, Smith AV, Zhang W, Okada Y, Stancáková A, Faul JD, Zhao W, Bartz TM, Concas MP, Franceschini N, Enroth S, Vitart V, Trompet S, Guo X, Chasman DI, O'Connel JR, Corre T, Nongmaithem SS, Chen Y, Mangino M, Ruggiero D, Traglia M, Farmaki AE, Kacprowski T, Bjonnes A, van der Spek A, Wu Y, Giri AK, Yanek LR, Wang L, Hofer E, Rietveld CA, McLeod O, Cornelis MC, Pattaro C, Verweij N, Baumbach C, Abdellaoui A, Warren HR, Vuckovic D, Mei H, Bouchard C, Perry JR, Cappellani S, Mirza SS, Benton MC, Broeckel U, Medland SE, Lind PA, Malerba G, Drong A, Yengo L, Bielak LF, Zhi D, van der Most PJ, Shriner D, Mägi R, Hemani G, Karaderi T, Wang Z, Liu T, Demuth I, Zhao JH, Meng W, Lataniotis L, van der Laan SW, Bradfield JP, Wood AR, Bonnefond A, Ahluwalia TS, Hall LM, Salvi E, Yazar S, Carstensen L, de Haan HG, Abney M, Afzal U, Allison MA, Amin N, Asselbergs FW, Bakker SJ, Barr RG, Baumeister SE, Benjamin DJ, Bergmann S, Boerwinkle E, Bottinger EP, Campbell A, Chakravarti A, Chan Y, Chanock SJ, Chen C, Chen YD, Collins FS, Connell J, Correa A, Cupples LA, Smith GD, Davies G, Dörr M, Ehret G, Ellis SB, Feenstra B, Feitosa MF, Ford I, Fox CS, Frayling TM, Friedrich N, Geller F, Scotland G, Gillham-Nasenya I, Gottesman O, Graff M, Grodstein F, Gu C, Haley C, Hammond CJ, Harris SE, Harris TB, Hastie ND, Heard-Costa NL, Heikkilä K, Hocking LJ, Homuth G, Hottenga JJ, Huang J, Huffman JE, Hysi PG, Ikram MA, Ingelsson E, Joensuu A, Johansson Å, Jousilahti P, Jukema JW, Kähönen M, Kamatani Y, Kanoni S, Kerr SM, Khan NM, Koellinger P, Koistinen HA, Kooner MK, Kubo M, Kuusisto J, Lahti J, Launer LJ, Lea RA, Lehne B, Lehtimäki T, Liewald DC, Lind L, Loh M, Lokki ML, London SJ, Loomis SJ, Loukola A, Lu Y, Lumley T, Lundqvist A, Männistö S, Marques-Vidal P, Masciullo C, Matchan A, Mathias RA, Matsuda K, Meigs JB, Meisinger C, Meitinger T, Menni C, Mentch FD, Mihailov E, Milani L, Montasser ME, Montgomery GW, Morrison A, Myers RH, Nadukuru R, Navarro P, Nelis M, Nieminen MS, Nolte IM, O'Connor GT, Ogunniyi A, Padmanabhan S, Palmas WR, Pankow JS, Patarcic I, Pavani F, Peyser PA, Pietilainen K, Poulter N, Prokopenko I, Ralhan S, Redmond P, Rich SS, Rissanen H, Robino A, Rose LM, Rose R, Sala C, Salako B, Salomaa V, Sarin AP, Saxena R, Schmidt H, Scott LJ, Scott WR, Sennblad B, Seshadri S, Sever P, Shrestha S, Smith BH, Smith JA, Soranzo N, Sotoodehnia N, Southam L, Stanton AV, Stathopoulou MG, Strauch K, Strawbridge RJ, Suderman MJ, Tandon N, Tang ST, Taylor KD, Tayo BO, Töglhofer AM, Tomaszewski M, Tšernikova N, Tuomilehto J, Uitterlinden AG, Vaidya D, van Hylckama Vlieg A, van Setten J, Vasankari T, Vedantam S, Vlachopoulou E, Vozzi D, Vuoksimaa E, Waldenberger M, Ware EB, Wentworth-Shields W, Whitfield JB, Wild S, Willemsen G, Yajnik CS, Yao J, Zaza G, Zhu X, Salem RM, Melbye M, Bisgaard H, Samani NJ, Cusi D, Mackey DA, Cooper RS, Froguel P, Pasterkamp G, Grant SF, Hakonarson H, Ferrucci L, Scott RA, Morris AD, Palmer CN, Dedoussis G, Deloukas P, Bertram L, Lindenberger U, Berndt SI, Lindgren CM, Timpson NJ, Tönjes A, Munroe PB, Sørensen TI, Rotimi CN, Arnett DK, Oldehinkel AJ, Kardia SL, Balkau B, Gambaro G, Morris AP, Eriksson JG, Wright MJ, Martin NG, Hunt SC, Starr JM, Deary IJ, Griffiths LR, Tiemeier H, Pirastu N, Kaprio J, Wareham NJ, Pérusse L, Wilson JG, Girotto G, Caulfield MJ, Raitakari O, Boomsma DI, Gieger C, van der Harst P, Hicks AA, Kraft P, Sinisalo J, Knekt P, Johannesson M, Magnusson PK, Hamsten A, Schmidt R, Borecki IB, Vartiainen E, Becker DM, Bharadwaj D, Mohlke KL, Boehnke M, van Duijn CM, Sanghera DK, Teumer A, Zeggini E, Metspalu A, Gasparini P, Ulivi S, Ober C, Toniolo D, Rudan I, Porteous DJ, Ciullo M, Spector TD, Hayward C, Dupuis J, Loos RJ, Wright AF, Chandak GR, Vollenweider P, Shuldiner AR, Ridker PM, Rotter JI, Sattar N, Gyllensten U, North KE, Pirastu M, Psaty BM, Weir DR, Laakso M, Gudnason V, Takahashi A, Chambers JC, et al. DirectionalView Related Profiles.

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Auer PL, Nalls M, Meschia JF, Worrall BB, Longstreth WT, Seshadri S, Kooperberg C, Burger KM, Carlson CS, Carty CL, Chen WM, Cupples LA, DeStefano AL, Fornage M, Hardy J, Hsu L, Jackson RD, Jarvik GP, Kim DS, Lakshminarayan K, Lange LA, Manichaikul A, Quinlan AR, Singleton AB, Thornton TA, Nickerson DA, Peters U, Rich SS. Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project. JAMA Neurol. 2015 Jul; 72(7):781-8.View Related Profiles.

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Wilker EH, Preis SR, Beiser AS, Wolf PA, Au R, Kloog I, Li W, Schwartz J, Koutrakis P, DeCarli C, Seshadri S, Mittleman MA. Long-term exposure to fine particulate matter, residential proximity to major roads and measures of brain structure. Stroke. 2015 May; 46(5):1161-6.View Related Profiles.

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Seshadri, Sudha

PMID: 25832410; PMCID: PMC4544703; DOI: 10.1038/nature14038;.

Agbenyikey W, Karasek R, Cifuentes M, Wolf PA, Seshadri S, Taylor JA, Beiser AS, Au R. Job strain and cognitive decline: a prospective study of the framingham offspring cohort. Int J Occup Environ Med. 2015 Apr; 6(2):79-94.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 25890602.

Gupta A, Preis SR, Beiser A, Devine S, Hankee L, Seshadri S, Wolf PA, Au R. Mid-life Cardiovascular Risk Impacts Memory Function: The Framingham Offspring Study. Alzheimer Dis Assoc Disord. 2015 Apr-Jun; 29(2):117-23.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
Preis, Sarah
Devine, Sherral
Seshadri, Sudha

PMID: 25187219; PMCID: PMC4345145; DOI: 10.1097/WAD.0000000000000059;.

Libon DJ, Preis SR, Beiser AS, Devine S, Seshadri S, Wolf PA, DeCarli C, Au R. Verbal memory and brain aging: an exploratory analysis of the role of error responses in the Framingham Study. Am J Alzheimers Dis Other Demen. 2015 Sep; 30(6):622-8.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
Preis, Sarah
Devine, Sherral
Seshadri, Sudha

PMID: 25788434; PMCID: PMC4536169; DOI: 10.1177/1533317515577184;.

Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, Beecham GW, Smith AV, Chouraki V, Hamilton-Nelson KL, Ikram MA, Fievet N, Denning N, Martin ER, Schmidt H, Kamatani Y, Dunstan ML, Valladares O, Laza AR, Zelenika D, Ramirez A, Foroud TM, Choi SH, Boland A, Becker T, Kukull WA, van der Lee SJ, Pasquier F, Cruchaga C, Beekly D, Fitzpatrick AL, Hanon O, Gill M, Barber R, Gudnason V, Campion D, Love S, Bennett DA, Amin N, Berr C, Tsolaki M, Buxbaum JD, Lopez OL, Deramecourt V, Fox NC, Cantwell LB, Tárraga L, Dufouil C, Hardy J, Crane PK, Eiriksdottir G, Hannequin D, Clarke R, Evans D, Mosley TH, Letenneur L, Brayne C, Maier W, De Jager P, Emilsson V, Dartigues JF, Hampel H, Kamboh MI, de Bruijn RF, Tzourio C, Pastor P, Larson EB, Rotter JI, O'Donovan MC, Montine TJ, Nalls MA, Mead S, Reiman EM, Jonsson PV, Holmes C, St George-Hyslop PH, Boada M, Passmore P, Wendland JR, Schmidt R, Morgan K, Winslow AR, Powell JF, Carasquillo M, Younkin SG, Jakobsdóttir J, Kauwe JS, Wilhelmsen KC, Rujescu D, Nöthen MM, Hofman A, Jones L, Haines JL, Psaty BM, Van Broeckhoven C, Holmans P, Launer LJ, Mayeux R, Lathrop M, Goate AM, Escott-Price V, Seshadri S, Pericak-Vance MA, Amouyel P, Williams J, van Duijn CM, Schellenberg GD, Farrer LA. A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry. 2016 Jan; 21(1):108-17.View Related Profiles.

DeStefano, Anita
Jun, Gyungah
Lunetta, Kathryn
Farrer, Lindsay
Seshadri, Sudha

PMID: 25778476; PMCID: PMC4573764; DOI: 10.1038/mp.2015.23;.

Mellinger JL, Pencina KM, Massaro JM, Hoffmann U, Seshadri S, Fox CS, O'Donnell CJ, Speliotes EK. Hepatic steatosis and cardiovascular disease outcomes: An analysis of the Framingham Heart Study. J Hepatol. 2015 Aug; 63(2):470-6.View Related Profiles.

Massaro, Joseph
Seshadri, Sudha

PMID: 25776891; DOI: 10.1016/j.jhep.2015.02.045;.

Kaess BM, Preis SR, Lieb W, Beiser AS, Yang Q, Chen TC, Hengstenberg C, Erdmann J, Schunkert H, Seshadri S, Vasan RS, Assimes TL, Deloukas P, Holm H, Kathiresan S, König IR, McPherson R, Reilly MP, Roberts R, Samani NJ, Stewart AF. Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community. J Am Heart Assoc. 2015 Mar; 4(3):e001544.View Related Profiles.

Beiser, Alexa
Kaess, Bernhard
Yang, Qiong
Preis, Sarah
Seshadri, Sudha
Chen, Tai
Ramachandran, Vasan

PMID: 25762803; PMCID: PMC4392437; DOI: 10.1161/JAHA.114.001544;.

Jefferson AL, Beiser AS, Himali JJ, Seshadri S, O'Donnell CJ, Manning WJ, Wolf PA, Au R, Benjamin EJ. Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study. Circulation. 2015 Apr 14; 131(15):1333-9.View Related Profiles.

Beiser, Alexa
Benjamin, Emelia
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 25700178; PMCID: PMC4398627; DOI: 10.1161/CIRCULATIONAHA.114.012438;.

Desikan RS, Schork AJ, Wang Y, Witoelar A, Sharma M, McEvoy LK, Holland D, Brewer JB, Chen CH, Thompson WK, Harold D, Williams J, Owen MJ, O'Donovan MC, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Schellenberg GD, Heutink P, Singleton AB, Brice A, Wood NW, Hardy J, Martinez M, Choi SH, DeStefano A, Ikram MA, Bis JC, Smith A, Fitzpatrick AL, Launer L, van Duijn C, Seshadri S, Ulstein ID, Aarsland D, Fladby T, Djurovic S, Hyman BT, Snaedal J, Stefansson H, Stefansson K, Gasser T, Andreassen OA, Dale AM. Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus. Mol Psychiatry. 2015 Dec; 20(12):1588-95.View Related Profiles.

DeStefano, Anita
Farrer, Lindsay
Seshadri, Sudha

PMID: 25687773; PMCID: PMC4539304; DOI: 10.1038/mp.2015.6;.

Verhaaren BF, Debette S, Bis JC, Smith JA, Ikram MK, Adams HH, Beecham AH, Rajan KB, Lopez LM, Barral S, van Buchem MA, van der Grond J, Smith AV, Hegenscheid K, Aggarwal NT, de Andrade M, Atkinson EJ, Beekman M, Beiser AS, Blanton SH, Boerwinkle E, Brickman AM, Bryan RN, Chauhan G, Chen CP, Chouraki V, de Craen AJ, Crivello F, Deary IJ, Deelen J, De Jager PL, Dufouil C, Elkind MS, Evans DA, Freudenberger P, Gottesman RF, Guðnason V, Habes M, Heckbert SR, Heiss G, Hilal S, Hofer E, Hofman A, Ibrahim-Verbaas CA, Knopman DS, Lewis CE, Liao J, Liewald DC, Luciano M, van der Lugt A, Martinez OO, Mayeux R, Mazoyer B, Nalls M, Nauck M, Niessen WJ, Oostra BA, Psaty BM, Rice KM, Rotter JI, von Sarnowski B, Schmidt H, Schreiner PJ, Schuur M, Sidney SS, Sigurdsson S, Slagboom PE, Stott DJ, van Swieten JC, Teumer A, Töglhofer AM, Traylor M, Trompet S, Turner ST, Tzourio C, Uh HW, Uitterlinden AG, Vernooij MW, Wang JJ, Wong TY, Wardlaw JM, Windham BG, Wittfeld K, Wolf C, Wright CB, Yang Q, Zhao W, Zijdenbos A, Jukema JW, Sacco RL, Kardia SL, Amouyel P, Mosley TH, Longstreth WT, DeCarli CC, van Duijn CM, Schmidt R, Launer LJ, Grabe HJ, Seshadri SS, Ikram MA, Fornage M. Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI. Circ Cardiovasc Genet. 2015 Apr; 8(2):398-409.View Related Profiles.

Beiser, Alexa
Yang, Qiong
Seshadri, Sudha

PMID: 25663218; PMCID: PMC4427240; DOI: 10.1161/CIRCGENETICS.114.000858;.

Rannikmäe K, Davies G, Thomson PA, Bevan S, Devan WJ, Falcone GJ, Traylor M, Anderson CD, Battey TW, Radmanesh F, Deka R, Woo JG, Martin LJ, Jimenez-Conde J, Selim M, Brown DL, Silliman SL, Kidwell CS, Montaner J, Langefeld CD, Slowik A, Hansen BM, Lindgren AG, Meschia JF, Fornage M, Bis JC, Debette S, Ikram MA, Longstreth WT, Schmidt R, Zhang CR, Yang Q, Sharma P, Kittner SJ, Mitchell BD, Holliday EG, Levi CR, Attia J, Rothwell PM, Poole DL, Boncoraglio GB, Psaty BM, Malik R, Rost N, Worrall BB, Dichgans M, Van Agtmael T, Woo D, Markus HS, Seshadri S, Rosand J, Sudlow CL. Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology. 2015 Mar 3; 84(9):918-26.View Related Profiles.

Yang, Qiong
Seshadri, Sudha

PMID: 25653287; PMCID: PMC4351667; DOI: 10.1212/WNL.0000000000001309;.

Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, Hofer E, Ibrahim-Verbaas CA, Kirin M, Lahti J, van der Lee SJ, Le Hellard S, Liu T, Marioni RE, Oldmeadow C, Postmus I, Smith AV, Smith JA, Thalamuthu A, Thomson R, Vitart V, Wang J, Yu L, Zgaga L, Zhao W, Boxall R, Harris SE, Hill WD, Liewald DC, Luciano M, Adams H, Ames D, Amin N, Amouyel P, Assareh AA, Au R, Becker JT, Beiser A, Berr C, Bertram L, Boerwinkle E, Buckley BM, Campbell H, Corley J, De Jager PL, Dufouil C, Eriksson JG, Espeseth T, Faul JD, Ford I, Gottesman RF, Griswold ME, Gudnason V, Harris TB, Heiss G, Hofman A, Holliday EG, Huffman J, Kardia SL, Kochan N, Knopman DS, Kwok JB, Lambert JC, Lee T, Li G, Li SC, Loitfelder M, Lopez OL, Lundervold AJ, Lundqvist A, Mather KA, Mirza SS, Nyberg L, Oostra BA, Palotie A, Papenberg G, Pattie A, Petrovic K, Polasek O, Psaty BM, Redmond P, Reppermund S, Rotter JI, Schmidt H, Schuur M, Schofield PW, Scott RJ, Steen VM, Stott DJ, van Swieten JC, Taylor KD, Trollor J, Trompet S, Uitterlinden AG, Weinstein G, Widen E, Windham BG, Jukema JW, Wright AF, Wright MJ, Yang Q, Amieva H, Attia JR, Bennett DA, Brodaty H, de Craen AJ, Hayward C, Ikram MA, Lindenberger U, Nilsson LG, Porteous DJ, Räikkönen K, Reinvang I, Rudan I, Sachdev PS, Schmidt R, Schofield PR, Srikanth V, Starr JM, Turner ST, Weir DR, Wilson JF, van Duijn C, Launer L, Fitzpatrick AL, Seshadri S, Mosley TH, Deary IJ. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Mol Psychiatry. 2015 Feb; 20(2):183-92.View Related Profiles.

Beiser, Alexa
Au, Rhoda
Seshadri, Sudha

PMID: 25644384; PMCID: PMC4356746; DOI: 10.1038/mp.2014.188;.

Shoamanesh A, Preis SR, Beiser AS, Vasan RS, Benjamin EJ, Kase CS, Wolf PA, DeCarli C, Romero JR, Seshadri S. Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study. Neurology. 2015 Feb 24; 84(8):825-32.View Related Profiles.

Beiser, Alexa
Shoamanesh, Ashkan
Kase, Carlos
Benjamin, Emelia
Romero, Jose
Wolf, Philip
Preis, Sarah
Seshadri, Sudha
Ramachandran, Vasan

PMID: 25632086; PMCID: PMC4345647; DOI: 10.1212/WNL.0000000000001279;.

Holliday EG, Traylor M, Malik R, Bevan S, Falcone G, Hopewell JC, Cheng YC, Cotlarciuc I, Bis JC, Boerwinkle E, Boncoraglio GB, Clarke R, Cole JW, Fornage M, Furie KL, Ikram MA, Jannes J, Kittner SJ, Lincz LF, Maguire JM, Meschia JF, Mosley TH, Nalls MA, Oldmeadow C, Parati EA, Psaty BM, Rothwell PM, Seshadri S, Scott RJ, Sharma P, Sudlow C, Wiggins KL, Worrall BB, Rosand J, Mitchell BD, Dichgans M, Markus HS, Levi C, Attia J, Wray NR. Genetic overlap between diagnostic subtypes of ischemic stroke. Stroke. 2015 Mar; 46(3):615-9. PMID: 25613305; PMCID: PMC4342266; DOI: 10.1161/STROKEAHA.114.007930;.

Hibar DP, Stein JL, Renteria ME, Arias-Vasquez A, Desrivières S, Jahanshad N, Toro R, Wittfeld K, Abramovic L, Andersson M, Aribisala BS, Armstrong NJ, Bernard M, Bohlken MM, Boks MP, Bralten J, Brown AA, Chakravarty MM, Chen Q, Ching CR, Cuellar-Partida G, den Braber A, Giddaluru S, Goldman AL, Grimm O, Guadalupe T, Hass J, Woldehawariat G, Holmes AJ, Hoogman M, Janowitz D, Jia T, Kim S, Klein M, Kraemer B, Lee PH, Olde Loohuis LM, Luciano M, Macare C, Mather KA, Mattheisen M, Milaneschi Y, Nho K, Papmeyer M, Ramasamy A, Risacher SL, Roiz-Santiañez R, Rose EJ, Salami A, Sämann PG, Schmaal L, Schork AJ, Shin J, Strike LT, Teumer A, van Donkelaar MM, van Eijk KR, Walters RK, Westlye LT, Whelan CD, Winkler AM, Zwiers MP, Alhusaini S, Athanasiu L, Ehrlich S, Hakobjan MM, Hartberg CB, Haukvik UK, Heister AJ, Hoehn D, Kasperaviciute D, Liewald DC, Lopez LM, Makkinje RR, Matarin M, Naber MA, McKay DR, Needham M, Nugent AC, Pütz B, Royle NA, Shen L, Sprooten E, Trabzuni D, van der Marel SS, van Hulzen KJ, Walton E, Wolf C, Almasy L, Ames D, Arepalli S, Assareh AA, Bastin ME, Brodaty H, Bulayeva KB, Carless MA, Cichon S, Corvin A, Curran JE, Czisch M, de Zubicaray GI, Dillman A, Duggirala R, Dyer TD, Erk S, Fedko IO, Ferrucci L, Foroud TM, Fox PT, Fukunaga M, Gibbs JR, Göring HH, Green RC, Guelfi S, Hansell NK, Hartman CA, Hegenscheid K, Heinz A, Hernandez DG, Heslenfeld DJ, Hoekstra PJ, Holsboer F, Homuth G, Hottenga JJ, Ikeda M, Jack CR, Jenkinson M, Johnson R, Kanai R, Keil M, Kent JW, Kochunov P, Kwok JB, Lawrie SM, Liu X, Longo DL, McMahon KL, Meisenzahl E, Melle I, Mohnke S, Montgomery GW, Mostert JC, Mühleisen TW, Nalls MA, Nichols TE, Nilsson LG, Nöthen MM, Ohi K, Olvera RL, Perez-Iglesias R, Pike GB, Potkin SG, Reinvang I, Reppermund S, Rietschel M, Romanczuk-Seiferth N, Rosen GD, Rujescu D, Schnell K, Schofield PR, Smith C, Steen VM, Sussmann JE, Thalamuthu A, Toga AW, Traynor BJ, Troncoso J, Turner JA, Valdés Hernández MC, van 't Ent D, van der Brug M, van der Wee NJ, van Tol MJ, Veltman DJ, Wassink TH, Westman E, Zielke RH, Zonderman AB, Ashbrook DG, Hager R, Lu L, McMahon FJ, Morris DW, Williams RW, Brunner HG, Buckner RL, Buitelaar JK, Cahn W, Calhoun VD, Cavalleri GL, Crespo-Facorro B, Dale AM, Davies GE, Delanty N, Depondt C, Djurovic S, Drevets WC, Espeseth T, Gollub RL, Ho BC, Hoffmann W, Hosten N, Kahn RS, Le Hellard S, Meyer-Lindenberg A, Müller-Myhsok B, Nauck M, Nyberg L, Pandolfo M, Penninx BW, Roffman JL, Sisodiya SM, Smoller JW, van Bokhoven H, van Haren NE, Völzke H, Walter H, Weiner MW, Wen W, White T, Agartz I, Andreassen OA, Blangero J, Boomsma DI, Brouwer RM, Cannon DM, Cookson MR, de Geus EJ, Deary IJ, Donohoe G, Fernández G, Fisher SE, Francks C, Glahn DC, Grabe HJ, Gruber O, Hardy J, Hashimoto R, Hulshoff Pol HE, Jönsson EG, Kloszewska I, Lovestone S, Mattay VS, Mecocci P, McDonald C, McIntosh AM, Ophoff RA, Paus T, Pausova Z, Ryten M, Sachdev PS, Saykin AJ, Simmons A, Singleton A, Soininen H, Wardlaw JM, Weale ME, Weinberger DR, Adams HH, Launer LJ, Seiler S, Schmidt R, Chauhan G, Satizabal CL, Becker JT, Yanek L, van der Lee SJ, Ebling M, Fischl B, Longstreth WT, Greve D, Schmidt H, Nyquist P, Vinke LN, van Duijn CM, Xue L, Mazoyer B, Bis JC, Gudnason V, Seshadri S, Ikram MA, Martin NG, Wright MJ, Schumann G, Franke B, Thompson PM, Medland SE. Common genetic variants influence human subcortical brain structures. Nature. 2015 Apr 9; 520(7546):224-9.View Related Profiles.

Satizabal, Claudia
Seshadri, Sudha

PMID: 25607358; PMCID: PMC4393366; DOI: 10.1038/nature14101;.

Lopez LM, Hill WD, Harris SE, Valdes Hernandez M, Munoz Maniega S, Bastin ME, Bailey E, Smith C, McBride M, McClure J, Graham D, Dominiczak A, Yang Q, Fornage M, Ikram MA, Debette S, Launer L, Bis JC, Schmidt R, Seshadri S, Porteous DJ, Starr J, Deary IJ, Wardlaw JM. Genes from a translational analysis support a multifactorial nature of white matter hyperintensities. Stroke. 2015 Feb; 46(2):341-7.View Related Profiles.

Yang, Qiong
Seshadri, Sudha

PMID: 25586835; PMCID: PMC4306534; DOI: 10.1161/STROKEAHA.114.007649;.

Pikula A, Beiser AS, Wang J, Himali JJ, Kelly-Hayes M, Kase CS, Yang Q, Seshadri S, Wolf PA. Lipid and lipoprotein measurements and the risk of ischemic vascular events: Framingham Study. Neurology. 2015 Feb 3; 84(5):472-9.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Himali, Jayandra
Kelly-Hayes, Margaret
Wolf, Philip
Yang, Qiong
Seshadri, Sudha

PMID: 25568296; PMCID: PMC4336066; DOI: 10.1212/WNL.0000000000001202;.

Chauhan G, Adams HH, Bis JC, Weinstein G, Yu L, Töglhofer AM, Smith AV, van der Lee SJ, Gottesman RF, Thomson R, Wang J, Yang Q, Niessen WJ, Lopez OL, Becker JT, Phan TG, Beare RJ, Arfanakis K, Fleischman D, Vernooij MW, Mazoyer B, Schmidt H, Srikanth V, Knopman DS, Jack CR, Amouyel P, Hofman A, DeCarli C, Tzourio C, van Duijn CM, Bennett DA, Schmidt R, Longstreth WT, Mosley TH, Fornage M, Launer LJ, Seshadri S, Ikram MA, Debette S. Association of Alzheimer's disease GWAS loci with MRI markers of brain aging. Neurobiol Aging. 2015 Apr; 36(4):1765.e7-16.View Related Profiles.

Weinstein, Galit
Yang, Qiong
Seshadri, Sudha

PMID: 25670335; PMCID: PMC4391343; DOI: 10.1016/j.neurobiolaging.2014.12.028;.

Miller IN, Himali JJ, Beiser AS, Murabito JM, Seshadri S, Wolf PA, Au R. Normative Data for the Cognitively Intact Oldest-Old: The Framingham Heart Study. Exp Aging Res. 2015; 41(4):386-409.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Murabito, Joanne
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 26214098; DOI: 10.1080/0361073X.2015.1053755;.

Nishtala A, Himali JJ, Beiser A, Murabito JM, Seshadri S, Wolf PA, Au R. Midlife Hypertension Risk and Cognition in the Non-Demented Oldest Old: Framingham Heart Study. J Alzheimers Dis. 2015; 47(1):197-204.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Murabito, Joanne
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 26402768; PMCID: PMC4827717; DOI: 10.3233/JAD-141881;.

Lebowitz BK, Weinstein C, Beiser A, Seshadri S, Wolf PA, Auerbach S, Au R. Lifelong Reading Disorder and Mild Cognitive Impairment: Implications for Diagnosis. J Alzheimers Dis. 2015; 50(1):41-5.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 26639959; PMCID: PMC4827707; DOI: 10.3233/JAD-150543;.

Jain S, Himali J, Beiser A, Ton TG, Kelly-Hayes M, Biggs ML, Delaney JA, Rosano C, Seshadri S, Frank SA. Validation of secondary data sources to identify Parkinson disease against clinical diagnostic criteria. Am J Epidemiol. 2015 Feb 1; 181(3):185-90.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Kelly-Hayes, Margaret
Seshadri, Sudha

PMID: 25550359; PMCID: PMC4312428; DOI: 10.1093/aje/kwu326;.

Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimers Dement. 2015 Jun; 11(6):658-71. PMID: 25533204; PMCID: PMC4672734; DOI: 10.1016/j.jalz.2014.05.1757;.

Jefferson AL, Beiser AS, Seshadri S, Wolf PA, Au R. APOE and mild cognitive impairment: the Framingham Heart Study. Age Ageing. 2015 Mar; 44(2):307-11.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 25497326; PMCID: PMC4400527; DOI: 10.1093/ageing/afu183;.

Debette S, Ibrahim Verbaas CA, Bressler J, Schuur M, Smith A, Bis JC, Davies G, Wolf C, Gudnason V, Chibnik LB, Yang Q, deStefano AL, de Quervain DJ, Srikanth V, Lahti J, Grabe HJ, Smith JA, Priebe L, Yu L, Karbalai N, Hayward C, Wilson JF, Campbell H, Petrovic K, Fornage M, Chauhan G, Yeo R, Boxall R, Becker J, Stegle O, Mather KA, Chouraki V, Sun Q, Rose LM, Resnick S, Oldmeadow C, Kirin M, Wright AF, Jonsdottir MK, Au R, Becker A, Amin N, Nalls MA, Turner ST, Kardia SL, Oostra B, Windham G, Coker LH, Zhao W, Knopman DS, Heiss G, Griswold ME, Gottesman RF, Vitart V, Hastie ND, Zgaga L, Rudan I, Polasek O, Holliday EG, Schofield P, Choi SH, Tanaka T, An Y, Perry RT, Kennedy RE, Sale MM, Wang J, Wadley VG, Liewald DC, Ridker PM, Gow AJ, Pattie A, Starr JM, Porteous D, Liu X, Thomson R, Armstrong NJ, Eiriksdottir G, Assareh AA, Kochan NA, Widen E, Palotie A, Hsieh YC, Eriksson JG, Vogler C, van Swieten JC, Shulman JM, Beiser A, Rotter J, Schmidt CO, Hoffmann W, Nöthen MM, Ferrucci L, Attia J, Uitterlinden AG, Amouyel P, Dartigues JF, Amieva H, Räikkönen K, Garcia M, Wolf PA, Hofman A, Longstreth WT, Psaty BM, Boerwinkle E, DeJager PL, Sachdev PS, Schmidt R, Breteler MM, Teumer A, Lopez OL, Cichon S, Chasman DI, Grodstein F, Müller-Myhsok B, Tzourio C, Papassotiropoulos A, Bennett DA, Ikram MA, Deary IJ, van Duijn CM, Launer L, Fitzpatrick AL, Seshadri S, Mosley TH. Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Biol Psychiatry. 2015 Apr 15; 77(8):749-63.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Wolf, Philip
Yang, Qiong
Au, Rhoda
Seshadri, Sudha
Hsieh, Yi-Chen

PMID: 25648963; PMCID: PMC4513651; DOI: 10.1016/j.biopsych.2014.08.027;.

Seshadri S. Indexes of subclinical atherosclerosis: signposts on the highway to disease. JACC Cardiovasc Imaging. 2014 Nov; 7(11):1116-8. PMID: 25459593; PMCID: PMC4356124; DOI: 10.1016/j.jcmg.2014.09.004;.

French CR, Seshadri S, Destefano AL, Fornage M, Arnold CR, Gage PJ, Skarie JM, Dobyns WB, Millen KJ, Liu T, Dietz W, Kume T, Hofker M, Emery DJ, Childs SJ, Waskiewicz AJ, Lehmann OJ. Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease. J Clin Invest. 2014 Nov; 124(11):4877-81.View Related Profiles.

DeStefano, Anita
Seshadri, Sudha

PMID: 25250569; PMCID: PMC4347243; DOI: 10.1172/JCI75109;.

Lüneburg N, Lieb W, Zeller T, Chen MH, Maas R, Carter AM, Xanthakis V, Glazer NL, Schwedhelm E, Seshadri S, Ikram MA, Longstreth WT, Fornage M, König IR, Loley C, Ojeda FM, Schillert A, Wang TJ, Sticht H, Kittel A, König J, Benjamin EJ, Sullivan LM, Bernges I, Anderssohn M, Ziegler A, Gieger C, Illig T, Meisinger C, Wichmann HE, Wild PS, Schunkert H, Psaty BM, Wiggins KL, Heckbert SR, Smith N, Lackner K, Lunetta KL, Blankenberg S, Erdmann J, Munzel T, Grant PJ, Vasan RS, Böger RH. Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine. Circ Cardiovasc Genet. 2014 Dec; 7(6):864-72.View Related Profiles.

Benjamin, Emelia
Lunetta, Kathryn
Sullivan, Lisa
Seshadri, Sudha
Xanthakis, Vanessa
Ramachandran, Vasan

PMID: 25245031; DOI: 10.1161/CIRCGENETICS.113.000264;.

Chouraki V, Beiser A, Younkin L, Preis SR, Weinstein G, Hansson O, Skoog I, Lambert JC, Au R, Launer L, Wolf PA, Younkin S, Seshadri S. Plasma amyloid-ß and risk of Alzheimer's disease in the Framingham Heart Study. Alzheimers Dement. 2015 Mar; 11(3):249-57.e1.View Related Profiles.

Beiser, Alexa
Weinstein, Galit
Wolf, Philip
Au, Rhoda
Preis, Sarah
Seshadri, Sudha

PMID: 25217292; PMCID: PMC4362883; DOI: 10.1016/j.jalz.2014.07.001;.

Broer L, Buchman AS, Deelen J, Evans DS, Faul JD, Lunetta KL, Sebastiani P, Smith JA, Smith AV, Tanaka T, Yu L, Arnold AM, Aspelund T, Benjamin EJ, De Jager PL, Eirkisdottir G, Evans DA, Garcia ME, Hofman A, Kaplan RC, Kardia SL, Kiel DP, Oostra BA, Orwoll ES, Parimi N, Psaty BM, Rivadeneira F, Rotter JI, Seshadri S, Singleton A, Tiemeier H, Uitterlinden AG, Zhao W, Bandinelli S, Bennett DA, Ferrucci L, Gudnason V, Harris TB, Karasik D, Launer LJ, Perls TT, Slagboom PE, Tranah GJ, Weir DR, Newman AB, van Duijn CM, Murabito JM. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J Gerontol A Biol Sci Med Sci. 2015 Jan; 70(1):110-8.View Related Profiles.

Benjamin, Emelia
Murabito, Joanne
Lunetta, Kathryn
Sebastiani, Paola
Seshadri, Sudha
Perls, Thomas

PMID: 25199915; PMCID: PMC4296168; DOI: 10.1093/gerona/glu166;.

Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R, Ikram MA, Ioannidis JP, Hadjigeorgiou GM, Bis JC, Martinez M, Perlmutter JS, Goate A, Marder K, Fiske B, Sutherland M, Xiromerisiou G, Myers RH, Clark LN, Stefansson K, Hardy JA, Heutink P, Chen H, Wood NW, Houlden H, Payami H, Brice A, Scott WK, Gasser T, Bertram L, Eriksson N, Foroud T, Singleton AB. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet. 2014 Sep; 46(9):989-93.View Related Profiles.

DeStefano, Anita
Myers, Richard
Seshadri, Sudha

PMID: 25064009; PMCID: PMC4146673; DOI: 10.1038/ng.3043;.

Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, Pare G, Sharma P, Slowik A, Thijs V, Walters M, Worrall BB, Sale MM, Algra A, Kappelle LJ, Wijmenga C, Norrving B, Sandling JK, Rönnblom L, Goris A, Franke A, Sudlow C, Rothwell PM, Levi C, Holliday EG, Fornage M, Psaty B, Gretarsdottir S, Thorsteinsdottir U, Seshadri S, Mitchell BD, Kittner S, Clarke R, Hopewell JC, Bis JC, Boncoraglio GB, Meschia J, Ikram MA, Hansen BM, Montaner J, Thorleifsson G, Stefanson K, Rosand J, de Bakker PI, Farrall M, Dichgans M, Markus HS, Bevan S. Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology. 2014 Aug 19; 83(8):678-85. PMID: 25031287; PMCID: PMC4150131; DOI: 10.1212/WNL.0000000000000707;.

Kaur B, Himali JJ, Seshadri S, Beiser AS, Au R, McKee AC, Auerbach S, Wolf PA, DeCarli CS. Association between neuropathology and brain volume in the Framingham Heart Study. Alzheimer Dis Assoc Disord. 2014 Jul-Sep; 28(3):219-25.View Related Profiles.

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McKee, Ann
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Auerbach, Sanford
Seshadri, Sudha

PMID: 24614264; PMCID: PMC4139422; DOI: 10.1097/WAD.0000000000000032;.

Bis JC, DeStefano A, Liu X, Brody JA, Choi SH, Verhaaren BF, Debette S, Ikram MA, Shahar E, Butler KR, Gottesman RF, Muzny D, Kovar CL, Psaty BM, Hofman A, Lumley T, Gupta M, Wolf PA, van Duijn C, Gibbs RA, Mosley TH, Longstreth WT, Boerwinkle E, Seshadri S, Fornage M. Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium. PLoS One. 2014; 9(6):e99798.View Related Profiles.

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Gupta, Mayetri
Wolf, Philip
Seshadri, Sudha

PMID: 24959832; PMCID: PMC4069013; DOI: 10.1371/journal.pone.0099798;.

Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, Jun G, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Denning N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Schmidt H, Kunkle B, Dunstan ML, Vronskaya M, Johnson AD, Ruiz A, Bihoreau MT, Reitz C, Pasquier F, Hollingworth P, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Hernández I, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, George-Hyslop PS, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Garcia FS, Fox NC, Hardy J, Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Scarpini E, Bonuccelli U, Mancuso M, Siciliano G, Moebus S, Mecocci P, Zompo MD, Maier W, Hampel H, Pilotto A, Frank-García A, Panza F, Solfrizzi V, Caffarra P, Nacmias B, Perry W, Mayhaus M, Lannfelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltunen M, Martin ER, Schmidt R, Rujescu D, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Haines JL, Lathrop M, Pericak-Vance MA, Launer LJ, Van Broeckhoven C, Farrer LA, van Duijn CM, Ramirez A, Seshadri S, Schellenberg GD, Amouyel P, Williams J. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. PLoS One. 2014; 9(6):e94661.View Related Profiles.

DeStefano, Anita
Jun, Gyungah
Farrer, Lindsay
Seshadri, Sudha

PMID: 24922517; PMCID: PMC4055488; DOI: 10.1371/journal.pone.0094661;.

Seshadri S, de Leeuw FE. Understanding brain function through small vessel disease: what zebras can teach us about horses. Neurology. 2014 Jun 3; 82(22):1940-1. PMID: 24793189; DOI: 10.1212/WNL.0000000000000484;.

Weinstein G, Seshadri S. Serum brain-derived neurotrophic factor as a predictor of incident dementia-reply. JAMA Neurol. 2014 May; 71(5):653-4.View Related Profiles.

Weinstein, Galit
Seshadri, Sudha

PMID: 24818683; DOI: 10.1001/jamaneurol.2014.215;.

Weinstein G, Preis SR, Beiser AS, Au R, Kelly-Hayes M, Kase CS, Wolf PA, Seshadri S. Cognitive performance after stroke--the Framingham Heart Study. Int J Stroke. 2014 Oct; 9 Suppl A100:48-54.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Weinstein, Galit
Kelly-Hayes, Margaret
Wolf, Philip
Au, Rhoda
Preis, Sarah
Seshadri, Sudha

PMID: 25352473; PMCID: PMC4215163; DOI: 10.1111/ijs.12275;.

Romero JR, Preis SR, Beiser A, DeCarli C, Viswanathan A, Martinez-Ramirez S, Kase CS, Wolf PA, Seshadri S. Risk factors, stroke prevention treatments, and prevalence of cerebral microbleeds in the Framingham Heart Study. Stroke. 2014 May; 45(5):1492-4.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Wolf, Philip
Preis, Sarah
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PMID: 24713533; PMCID: PMC4048617; DOI: 10.1161/STROKEAHA.114.004130;.

Kim DS, Crosslin DR, Auer PL, Suzuki SM, Marsillach J, Burt AA, Gordon AS, Meschia JF, Nalls MA, Worrall BB, Longstreth WT, Gottesman RF, Furlong CE, Peters U, Rich SS, Nickerson DA, Jarvik GP. Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. J Lipid Res. 2014 Jun; 55(6):1173-8. PMID: 24711634; PMCID: PMC4031948; DOI: 10.1194/jlr.P049247;.

Westwood AJ, Beiser A, Decarli C, Harris TB, Chen TC, He XM, Roubenoff R, Pikula A, Au R, Braverman LE, Wolf PA, Vasan RS, Seshadri S. Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy. Neurology. 2014 May 6; 82(18):1613-9.View Related Profiles.

Pikula, Aleksandra
Beiser, Alexa
Braverman, Lewis
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Chen, Tai
Ramachandran, Vasan

PMID: 24706014; PMCID: PMC4013812; DOI: 10.1212/WNL.0000000000000382;.

Williams SR, Yang Q, Chen F, Liu X, Keene KL, Jacques P, Chen WM, Weinstein G, Hsu FC, Beiser A, Wang L, Bookman E, Doheny KF, Wolf PA, Zilka M, Selhub J, Nelson S, Gogarten SM, Worrall BB, Seshadri S, Sale MM. Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke. PLoS Genet. 2014 Mar; 10(3):e1004214.View Related Profiles.

Beiser, Alexa
Weinstein, Galit
Wolf, Philip
Yang, Qiong
Seshadri, Sudha

PMID: 24651765; PMCID: PMC3961178; DOI: 10.1371/journal.pgen.1004214;.

Ruiz A, Heilmann S, Becker T, Hernández I, Wagner H, Thelen M, Mauleón A, Rosende-Roca M, Bellenguez C, Bis JC, Harold D, Gerrish A, Sims R, Sotolongo-Grau O, Espinosa A, Alegret M, Arrieta JL, Lacour A, Leber M, Becker J, Lafuente A, Ruiz S, Vargas L, Rodríguez O, Ortega G, Dominguez MA, Mayeux R, Haines JL, Pericak-Vance MA, Farrer LA, Schellenberg GD, Chouraki V, Launer LJ, van Duijn C, Seshadri S, Antúnez C, Breteler MM, Serrano-Ríos M, Jessen F, Tárraga L, Nöthen MM, Maier W, Boada M, Ramírez A. Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene. Transl Psychiatry. 2014; 4:e358.View Related Profiles.

Farrer, Lindsay
Seshadri, Sudha

PMID: 24495969; PMCID: PMC3944635; DOI: 10.1038/tp.2014.2;.

Barnes DE, Beiser AS, Lee A, Langa KM, Koyama A, Preis SR, Neuhaus J, McCammon RJ, Yaffe K, Seshadri S, Haan MN, Weir DR. Development and validation of a brief dementia screening indicator for primary care. Alzheimers Dement. 2014 Nov; 10(6):656-665.e1.View Related Profiles.

Beiser, Alexa
Preis, Sarah
Seshadri, Sudha

PMID: 24491321; PMCID: PMC4119094; DOI: 10.1016/j.jalz.2013.11.006;.

Weinstein G, Seshadri S. Circulating biomarkers that predict incident dementia. Alzheimers Res Ther. 2014; 6(1):6.View Related Profiles.

Weinstein, Galit
Seshadri, Sudha

PMID: 25031629; DOI: 10.1186/alzrt235;.

Malik R, Bevan S, Nalls MA, Holliday EG, Devan WJ, Cheng YC, Ibrahim-Verbaas CA, Verhaaren BF, Bis JC, Joon AY, de Stefano AL, Fornage M, Psaty BM, Ikram MA, Launer LJ, van Duijn CM, Sharma P, Mitchell BD, Rosand J, Meschia JF, Levi C, Rothwell PM, Sudlow C, Markus HS, Seshadri S, Dichgans M. Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies. Stroke. 2014 Feb; 45(2):394-402. PMID: 24436234; PMCID: PMC4006951; DOI: 10.1161/STROKEAHA.113.002938;.

Ibrahim-Verbaas CA, Fornage M, Bis JC, Choi SH, Psaty BM, Meigs JB, Rao M, Nalls M, Fontes JD, O'Donnell CJ, Kathiresan S, Ehret GB, Fox CS, Malik R, Dichgans M, Schmidt H, Lahti J, Heckbert SR, Lumley T, Rice K, Rotter JI, Taylor KD, Folsom AR, Boerwinkle E, Rosamond WD, Shahar E, Gottesman RF, Koudstaal PJ, Amin N, Wieberdink RG, Dehghan A, Hofman A, Uitterlinden AG, Destefano AL, Debette S, Xue L, Beiser A, Wolf PA, Decarli C, Ikram MA, Seshadri S, Mosley TH, Longstreth WT, van Duijn CM, Launer LJ. Predicting stroke through genetic risk functions: the CHARGE Risk Score Project. Stroke. 2014 Feb; 45(2):403-12.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Wolf, Philip
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PMID: 24436238; PMCID: PMC3955258; DOI: 10.1161/STROKEAHA.113.003044;.

Chêne G, Beiser A, Au R, Preis SR, Wolf PA, Dufouil C, Seshadri S. Gender and incidence of dementia in the Framingham Heart Study from mid-adult life. Alzheimers Dement. 2015 Mar; 11(3):310-20.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
Preis, Sarah
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PMID: 24418058; PMCID: PMC4092061; DOI: 10.1016/j.jalz.2013.10.005;.

Nishtala A, Preis SR, Beiser A, Devine S, Hankee L, Seshadri S, Wolf PA, Au R. Midlife cardiovascular risk impacts executive function: Framingham offspring study. Alzheimer Dis Assoc Disord. 2014 Jan-Mar; 28(1):16-22.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
Preis, Sarah
Devine, Sherral
Seshadri, Sudha

PMID: 23995818; PMCID: PMC3945114; DOI: 10.1097/WAD.0b013e3182a715bc;.

Weinstein G, Beiser AS, Choi SH, Preis SR, Chen TC, Vorgas D, Au R, Pikula A, Wolf PA, DeStefano AL, Vasan RS, Seshadri S. Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study. JAMA Neurol. 2014 Jan; 71(1):55-61.View Related Profiles.

Pikula, Aleksandra
Beiser, Alexa
DeStefano, Anita
Weinstein, Galit
Wolf, Philip
Au, Rhoda
Preis, Sarah
Seshadri, Sudha
Chen, Tai
Ramachandran, Vasan

PMID: 24276217; PMCID: PMC4056186; DOI: 10.1001/jamaneurol.2013.4781;.

Chouraki V, Seshadri S. Genetics of Alzheimer's disease. Adv Genet. 2014; 87:245-94. PMID: 25311924; DOI: 10.1016/B978-0-12-800149-3.00005-6;.

Dufouil C, Seshadri S, Chêne G. Cardiovascular risk profile in women and dementia. J Alzheimers Dis. 2014; 42 Suppl 4:S353-63. PMID: 25351109; DOI: 10.3233/JAD-141629;.

Dichgans M, Malik R, König IR, Rosand J, Clarke R, Gretarsdottir S, Thorleifsson G, Mitchell BD, Assimes TL, Levi C, O'Donnell CJ, Fornage M, Thorsteinsdottir U, Psaty BM, Hengstenberg C, Seshadri S, Erdmann J, Bis JC, Peters A, Boncoraglio GB, März W, Meschia JF, Kathiresan S, Ikram MA, McPherson R, Stefansson K, Sudlow C, Reilly MP, Thompson JR, Sharma P, Hopewell JC, Chambers JC, Watkins H, Rothwell PM, Roberts R, Markus HS, Samani NJ, Farrall M, Schunkert H. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke. 2014 Jan; 45(1):24-36.View Related Profiles.

DeStefano, Anita
Seshadri, Sudha

PMID: 24262325; PMCID: PMC4112102; DOI: 10.1161/STROKEAHA.113.002707;.

Murabito JM, Beiser AS, Decarli C, Seshadri S, Wolf PA, Au R. Parental longevity is associated with cognition and brain ageing in middle-aged offspring. Age Ageing. 2014 May; 43(3):358-63.View Related Profiles.

Beiser, Alexa
Murabito, Joanne
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 24212919; PMCID: PMC4001170; DOI: 10.1093/ageing/aft175;.

Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Rockwood K, Xiao S, Li J, Li X, Brayne C, Matthews FE, Stephan BC, Lipton RB, Katz MJ, Ritchie K, Carrière I, Ancelin ML, Seshadri S, Au R, Beiser AS, Lam LC, Wong CH, Fung AW, Kim KW, Han JW, Kim TH, Petersen RC, Roberts RO, Mielke MM, Ganguli M, Dodge HH, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Meguro K, Schupf N, Manly J, Stern Y, Lobo A, Lopez-Anton R, Santabárbara J. COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. BMC Neurol. 2013; 13:165.View Related Profiles.

Beiser, Alexa
Au, Rhoda
Seshadri, Sudha

PMID: 24195705; PMCID: PMC3827845; DOI: 10.1186/1471-2377-13-165;.

Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MW, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuiness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Deniz Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F, Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannefelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltuenen M, Martin ER, Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg GD, Amouyel P. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet. 2013 Dec; 45(12):1452-8.View Related Profiles.

DeStefano, Anita
Jun, Gyungah
Lunetta, Kathryn
Farrer, Lindsay
Wolf, Philip
Seshadri, Sudha

PMID: 24162737; PMCID: PMC3896259; DOI: 10.1038/ng.2802;.

Ahl RE, Beiser A, Seshadri S, Auerbach S, Wolf PA, Au R. Defining MCI in the Framingham Heart Study Offspring: education versus WRAT-based norms. Alzheimer Dis Assoc Disord. 2013 Oct-Dec; 27(4):330-6.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
Auerbach, Sanford
Seshadri, Sudha

PMID: 23314066; PMCID: PMC3626741; DOI: 10.1097/WAD.0b013e31827bde32;.

Rosenquist KJ, Massaro JM, Pencina KM, D'Agostino RB, Beiser A, O'Connor GT, O'Donnell CJ, Wolf PA, Polak JF, Seshadri S, Fox CS. Neck circumference, carotid wall intima-media thickness, and incident stroke. Diabetes Care. 2013 Sep; 36(9):e153-4.View Related Profiles.

Beiser, Alexa
O'Connor, George
Massaro, Joseph
Wolf, Philip
D'Agostino, Ralph
Seshadri, Sudha

PMID: 23970728; PMCID: PMC3747939; DOI: 10.2337/dc13-0379;.

Pekkala S, Wiener D, Himali JJ, Beiser AS, Obler LK, Liu Y, McKee A, Auerbach S, Seshadri S, Wolf PA, Au R. Lexical retrieval in discourse: an early indicator of Alzheimer's dementia. Clin Linguist Phon. 2013 Dec; 27(12):905-21.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Obler, Loraine
Wolf, Philip
Au, Rhoda
Auerbach, Sanford
Seshadri, Sudha

PMID: 23985011; PMCID: PMC4095845; DOI: 10.3109/02699206.2013.815278;.

Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD, Teumer A, Reiner AP, Folkersen L, Basu S, Rudnicka AR, Trompet S, Mälarstig A, Baumert J, Bis JC, Guo X, Hottenga JJ, Shin SY, Lopez LM, Lahti J, Tanaka T, Yanek LR, Oudot-Mellakh T, Wilson JF, Navarro P, Huffman JE, Zemunik T, Redline S, Mehra R, Pulanic D, Rudan I, Wright AF, Kolcic I, Polasek O, Wild SH, Campbell H, Curb JD, Wallace R, Liu S, Eaton CB, Becker DM, Becker LC, Bandinelli S, Räikkönen K, Widen E, Palotie A, Fornage M, Green D, Gross M, Davies G, Harris SE, Liewald DC, Starr JM, Williams FM, Grant PJ, Spector TD, Strawbridge RJ, Silveira A, Sennblad B, Rivadeneira F, Uitterlinden AG, Franco OH, Hofman A, van Dongen J, Willemsen G, Boomsma DI, Yao J, Swords Jenny N, Haritunians T, McKnight B, Lumley T, Taylor KD, Rotter JI, Psaty BM, Peters A, Gieger C, Illig T, Grotevendt A, Homuth G, Völzke H, Kocher T, Goel A, Franzosi MG, Seedorf U, Clarke R, Steri M, Tarasov KV, Sanna S, Schlessinger D, Stott DJ, Sattar N, Buckley BM, Rumley A, Lowe GD, McArdle WL, Chen MH, Tofler GH, Song J, Boerwinkle E, Folsom AR, Rose LM, Franco-Cereceda A, Teichert M, Ikram MA, Mosley TH, Bevan S, Dichgans M, Rothwell PM, Sudlow CL, Hopewell JC, Chambers JC, Saleheen D, Kooner JS, Danesh J, Nelson CP, Erdmann J, Reilly MP, Kathiresan S, Schunkert H, Morange PE, Ferrucci L, Eriksson JG, Jacobs D, Deary IJ, Soranzo N, Witteman JC, de Geus EJ, Tracy RP, Hayward C, Koenig W, Cucca F, Jukema JW, Eriksson P, Seshadri S, Markus HS, Watkins H, Samani NJ, Wallaschofski H, Smith NL, Tregouet D, Ridker PM, Tang W, Strachan DP, Hamsten A, O'Donnell CJ. Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation. 2013 Sep 17; 128(12):1310-24.View Related Profiles.

Chen, Ming-Huei
Seshadri, Sudha

PMID: 23969696; PMCID: PMC3842025; DOI: 10.1161/CIRCULATIONAHA.113.002251;.

Tsao CW, Seshadri S, Beiser AS, Westwood AJ, Decarli C, Au R, Himali JJ, Hamburg NM, Vita JA, Levy D, Larson MG, Benjamin EJ, Wolf PA, Vasan RS, Mitchell GF. Relations of arterial stiffness and endothelial function to brain aging in the community. Neurology. 2013 Sep 10; 81(11):984-91.View Related Profiles.

Beiser, Alexa
Benjamin, Emelia
Himali, Jayandra
Vita, Joseph
Larson, Martin
Hamburg, Naomi
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Ramachandran, Vasan

PMID: 23935179; DOI: 10.1212/WNL.0b013e3182a43e1c;.

Pikula A, Beiser AS, Chen TC, Preis SR, Vorgias D, DeCarli C, Au R, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S. Serum brain-derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury: Framingham Study. Stroke. 2013 Oct; 44(10):2768-75.View Related Profiles.

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PMID: 23929745; DOI: 10.1161/STROKEAHA.113.001447;.

Weinstein G, Beiser AS, Decarli C, Au R, Wolf PA, Seshadri S. Brain imaging and cognitive predictors of stroke and Alzheimer disease in the Framingham Heart Study. Stroke. 2013 Oct; 44(10):2787-94.View Related Profiles.

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PMID: 23920020; DOI: 10.1161/STROKEAHA.113.000947;.

Seshadri S. Delaying dementia: can antihypertensives prevent Alzheimer dementia? Neurology. 2013 Sep 3; 81(10):860-2. PMID: 23911755; DOI: 10.1212/WNL.0b013e3182a35296;.

Boada M, Antúnez C, Ramírez-Lorca R, DeStefano AL, González-Pérez A, Gayán J, López-Arrieta J, Ikram MA, Hernández I, Marín J, Galán JJ, Bis JC, Mauleón A, Rosende-Roca M, Moreno-Rey C, Gudnasson V, Morón FJ, Velasco J, Carrasco JM, Alegret M, Espinosa A, Vinyes G, Lafuente A, Vargas L, Fitzpatrick AL, Launer LJ, Sáez ME, Vázquez E, Becker JT, López OL, Serrano-Ríos M, Tárraga L, van Duijn CM, Real LM, Seshadri S, Ruiz A. ATP5H/KCTD2 locus is associated with Alzheimer's disease risk. Mol Psychiatry. 2014 Jun; 19(6):682-7.View Related Profiles.

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PMID: 23857120; PMCID: PMC4031637; DOI: 10.1038/mp.2013.86;.

Schilling S, DeStefano AL, Sachdev PS, Choi SH, Mather KA, DeCarli CD, Wen W, Høgh P, Raz N, Au R, Beiser A, Wolf PA, Romero JR, Zhu YC, Lunetta KL, Farrer L, Dufouil C, Kuller LH, Mazoyer B, Seshadri S, Tzourio C, Debette S. APOE genotype and MRI markers of cerebrovascular disease: systematic review and meta-analysis. Neurology. 2013 Jul 16; 81(3):292-300.View Related Profiles.

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PMID: 23858411; PMCID: PMC3770168; DOI: 10.1212/WNL.0b013e31829bfda4;.

Johnsen JM, Auer PL, Morrison AC, Jiao S, Wei P, Haessler J, Fox K, McGee SR, Smith JD, Carlson CS, Smith N, Boerwinkle E, Kooperberg C, Nickerson DA, Rich SS, Green D, Peters U, Cushman M, Reiner AP. Common and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI Exome Sequencing Project. Blood. 2013 Jul 25; 122(4):590-7.View Related Profiles.

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PMID: 23690449; PMCID: PMC3724194; DOI: 10.1182/blood-2013-02-485094;.

Li M, Luo XJ, Rietschel M, Lewis CM, Mattheisen M, Müller-Myhsok B, Jamain S, Leboyer M, Landén M, Thompson PM, Cichon S, Nöthen MM, Schulze TG, Sullivan PF, Bergen SE, Donohoe G, Morris DW, Hargreaves A, Gill M, Corvin A, Hultman C, Toga AW, Shi L, Lin Q, Shi H, Gan L, Meyer-Lindenberg A, Czamara D, Henry C, Etain B, Bis JC, Ikram MA, Fornage M, Debette S, Launer LJ, Seshadri S, Erk S, Walter H, Heinz A, Bellivier F, Stein JL, Medland SE, Vasquez AA, Hibar DP, Franke B, Martin NG, Wright MJ. Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility. Mol Psychiatry. 2014 Apr; 19(4):527. PMID: 23670488; DOI: 10.1038/mp.2013.73;.

Romero JR, Mercado M, Beiser AS, Pikula A, Seshadri S, Kelly-Hayes M, Wolf PA, Kase CS. Transient global amnesia and neurological events: the framingham heart study. Front Neurol. 2013; 4:47.View Related Profiles.

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PMID: 23675365; PMCID: PMC3653124; DOI: 10.3389/fneur.2013.00047;.

Bangen KJ, Beiser A, Delano-Wood L, Nation DA, Lamar M, Libon DJ, Bondi MW, Seshadri S, Wolf PA, Au R. APOE genotype modifies the relationship between midlife vascular risk factors and later cognitive decline. J Stroke Cerebrovasc Dis. 2013 Nov; 22(8):1361-9.View Related Profiles.

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PMID: 23601373; PMCID: PMC3849195; DOI: 10.1016/j.jstrokecerebrovasdis.2013.03.013;.

Li M, Luo XJ, Rietschel M, Lewis CM, Mattheisen M, Müller-Myhsok B, Jamain S, Leboyer M, Landén M, Thompson PM, Cichon S, Nöthen MM, Schulze TG, Sullivan PF, Bergen SE, Donohoe G, Morris DW, Hargreaves A, Gill M, Corvin A, Hultman C, Toga AW, Shi L, Lin Q, Shi H, Gan L, Meyer-Lindenberg A, Czamara D, Henry C, Etain B, Bis JC, Ikram MA, Fornage M, Debette S, Launer LJ, Seshadri S, Erk S, Walter H, Heinz A, Bellivier F, Stein JL, Medland SE, Arias Vasquez A, Hibar DP, Franke B, Martin NG, Wright MJ, Su B. Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility. Mol Psychiatry. 2014 Apr; 19(4):452-61. PMID: 23568192; PMCID: PMC3937299; DOI: 10.1038/mp.2013.37;.

Norton N, Li D, Rampersaud E, Morales A, Martin ER, Zuchner S, Guo S, Gonzalez M, Hedges DJ, Robertson PD, Krumm N, Nickerson DA, Hershberger RE. Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy. Circ Cardiovasc Genet. 2013 Apr; 6(2):144-53.View Related Profiles.

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PMID: 23418287; PMCID: PMC3815606; DOI: 10.1161/CIRCGENETICS.111.000062;.

Weinstein G, Beiser AS, Au R, Decarli C, Wolf PA, Seshadri S. Association of parental stroke with brain injury and cognitive measures in offspring: the Framingham Heart Study. Stroke. 2013 Mar; 44(3):812-5.View Related Profiles.

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PMID: 23362080; PMCID: PMC3752976; DOI: 10.1161/STROKEAHA.112.680520;.

Williams FM, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, Traylor M, Bevan S, Dichgans M, Rothwell PM, Sudlow C, Farrall M, Silander K, Kaunisto M, Wagner P, Saarela O, Kuulasmaa K, Virtamo J, Salomaa V, Amouyel P, Arveiler D, Ferrieres J, Wiklund PG, Ikram MA, Hofman A, Boncoraglio GB, Parati EA, Helgadottir A, Gretarsdottir S, Thorsteinsdottir U, Thorleifsson G, Stefansson K, Seshadri S, DeStefano A, Gschwendtner A, Psaty B, Longstreth W, Mitchell BD, Cheng YC, Clarke R, Ferrario M, Bis JC, Levi C, Attia J, Holliday EG, Scott RJ, Fornage M, Sharma P, Furie KL, Rosand J, Nalls M, Meschia J, Mosely TH, Evans A, Palotie A, Markus HS, Grant PJ, Spector TD. Ischemic stroke is associated with the ABO locus: the EuroCLOT study. Ann Neurol. 2013 Jan; 73(1):16-31.View Related Profiles.

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Seshadri, Sudha

PMID: 23381943; PMCID: PMC3582024; DOI: 10.1002/ana.23838;.

Nyborn JA, Himali JJ, Beiser AS, Devine SA, Du Y, Kaplan E, O'Connor MK, Rinn WE, Denison HS, Seshadri S, Wolf PA, Au R. The Framingham Heart Study clock drawing performance: normative data from the offspring cohort. Exp Aging Res. 2013; 39(1):80-108.View Related Profiles.

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PMID: 23316738; PMCID: PMC3612583; DOI: 10.1080/0361073X.2013.741996;.

Weinstein G, Wolf PA, Beiser AS, Au R, Seshadri S. Risk estimations, risk factors, and genetic variants associated with Alzheimer's disease in selected publications from the Framingham Heart Study. J Alzheimers Dis. 2013; 33 Suppl 1:S439-45.View Related Profiles.

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PMID: 22796871; PMCID: PMC3672236.

Hankee LD, Preis SR, Beiser AS, Devine SA, Liu Y, Seshadri S, Wolf PA, Au R. Qualitative neuropsychological measures: normative data on executive functioning tests from the Framingham offspring study. Exp Aging Res. 2013; 39(5):515-35.View Related Profiles.

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Wolf, Philip
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PMID: 24151914; PMCID: PMC3836045; DOI: 10.1080/0361073X.2013.839029;.

Annweiler C, Montero-Odasso M, Hachinski V, Seshadri S, Bartha R, Beauchet O. Vitamin D concentration and lateral cerebral ventricle volume in older adults. Mol Nutr Food Res. 2013 Feb; 57(2):267-76. PMID: 23281306; DOI: 10.1002/mnfr.201200418;.

Chen MH, Huang J, Chen WM, Larson MG, Fox CS, Vasan RS, Seshadri S, O'Donnell CJ, Yang Q. Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study. PLoS One. 2012; 7(12):e51589.View Related Profiles.

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PMID: 23284720; PMCID: PMC3524237; DOI: 10.1371/journal.pone.0051589;.

Fu W, O'Connor TD, Jun G, Kang HM, Abecasis G, Leal SM, Gabriel S, Rieder MJ, Altshuler D, Shendure J, Nickerson DA, Bamshad MJ, Akey JM. Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature. 2013 Jan 10; 493(7431):216-20.View Related Profiles.

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PMID: 23201682; PMCID: PMC3676746; DOI: 10.1038/nature11690;.

Maillard P, Seshadri S, Beiser A, Himali JJ, Au R, Fletcher E, Carmichael O, Wolf PA, DeCarli C. Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study. Lancet Neurol. 2012 Dec; 11(12):1039-47.View Related Profiles.

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PMID: 23122892; PMCID: PMC3510663; DOI: 10.1016/S1474-4422(12)70241-7;.

Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng YC, Fornage M, Ikram MA, Malik R, Bevan S, Thorsteinsdottir U, Nalls MA, Longstreth W, Wiggins KL, Yadav S, Parati EA, Destefano AL, Worrall BB, Kittner SJ, Khan MS, Reiner AP, Helgadottir A, Achterberg S, Fernandez-Cadenas I, Abboud S, Schmidt R, Walters M, Chen WM, Ringelstein EB, O'Donnell M, Ho WK, Pera J, Lemmens R, Norrving B, Higgins P, Benn M, Sale M, Kuhlenbäumer G, Doney AS, Vicente AM, Delavaran H, Algra A, Davies G, Oliveira SA, Palmer CN, Deary I, Schmidt H, Pandolfo M, Montaner J, Carty C, de Bakker PI, Kostulas K, Ferro JM, van Zuydam NR, Valdimarsson E, Nordestgaard BG, Lindgren A, Thijs V, Slowik A, Saleheen D, Paré G, Berger K, Thorleifsson G, Hofman A, Mosley TH, Mitchell BD, Furie K, Clarke R, Levi C, Seshadri S, Gschwendtner A, Boncoraglio GB, Sharma P, Bis JC, Gretarsdottir S, Psaty BM, Rothwell PM, Rosand J, Meschia JF, Stefansson K, Dichgans M, Markus HS. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol. 2012 Nov; 11(11):951-62.View Related Profiles.

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Seshadri, Sudha

PMID: 23041239; PMCID: PMC3490334; DOI: 10.1016/S1474-4422(12)70234-X;.

Jun G, Moncaster JA, Koutras C, Seshadri S, Buros J, McKee AC, Levesque G, Wolf PA, St George-Hyslop P, Goldstein LE, Farrer LA. d-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes. PLoS One. 2012; 7(9):e43728.View Related Profiles.

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PMID: 22984439; PMCID: PMC3439481; DOI: 10.1371/journal.pone.0043728;.

Romero JR, Preis SR, Beiser AS, DeCarli C, Lee DY, Viswanathan A, Benjamin EJ, Fontes J, Au R, Pikula A, Wang J, Kase CS, Wolf PA, Irrizary MC, Seshadri S. Lipoprotein phospholipase A2 and cerebral microbleeds in the Framingham Heart Study. Stroke. 2012 Nov; 43(11):3091-4.View Related Profiles.

Pikula, Aleksandra
Beiser, Alexa
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PMID: 22961963; PMCID: PMC3544291; DOI: 10.1161/STROKEAHA.112.656744;.

Emond MJ, Louie T, Emerson J, Zhao W, Mathias RA, Knowles MR, Wright FA, Rieder MJ, Tabor HK, Nickerson DA, Barnes KC, Gibson RL, Bamshad MJ. Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. Nat Genet. 2012 Aug; 44(8):886-9.View Related Profiles.

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Seshadri, Sudha

PMID: 22772370; PMCID: PMC3702264; DOI: 10.1038/ng.2344;.

Boileau C, Guo DC, Hanna N, Regalado ES, Detaint D, Gong L, Varret M, Prakash SK, Li AH, d'Indy H, Braverman AC, Grandchamp B, Kwartler CS, Gouya L, Santos-Cortez RL, Abifadel M, Leal SM, Muti C, Shendure J, Gross MS, Rieder MJ, Vahanian A, Nickerson DA, Michel JB, Jondeau G, Milewicz DM. TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome. Nat Genet. 2012 Aug; 44(8):916-21.View Related Profiles.

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PMID: 22772371; DOI: 10.1038/ng.2348;.

Kao PF, Banigan MG, Vanderburg CR, McKee AC, Polgar PR, Seshadri S, Delalle I. Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology. J Neuropathol Exp Neurol. 2012 Jul; 71(7):654-64.View Related Profiles.

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Polgar, Peter
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PMID: 22710966; PMCID: PMC3398703; DOI: 10.1097/NEN.0b013e31825d06b7;.

Au R, Seshadri S, Knox K, Beiser A, Himali JJ, Cabral HJ, Auerbach S, Green RC, Wolf PA, McKee AC. The Framingham Brain Donation Program: neuropathology along the cognitive continuum. Curr Alzheimer Res. 2012 Jul; 9(6):673-86.View Related Profiles.

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McKee, Ann
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Wolf, Philip
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PMID: 22471865; PMCID: PMC3622706.

van Himbergen TM, Beiser AS, Ai M, Seshadri S, Otokozawa S, Au R, Thongtang N, Wolf PA, Schaefer EJ. Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study. Arch Neurol. 2012 May; 69(5):594-600.View Related Profiles.

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Wolf, Philip
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PMID: 22213409; PMCID: PMC3512190.

Seshadri S. Homocysteine and the risk of dementia. Clin Chem. 2012 Jun; 58(6):1059-60. PMID: 22510400; DOI: 10.1373/clinchem.2011.181099;.

Stein JL, Medland SE, Vasquez AA, Hibar DP, Senstad RE, Winkler AM, Toro R, Appel K, Bartecek R, Bergmann Ø, Bernard M, Brown AA, Cannon DM, Chakravarty MM, Christoforou A, Domin M, Grimm O, Hollinshead M, Holmes AJ, Homuth G, Hottenga JJ, Langan C, Lopez LM, Hansell NK, Hwang KS, Kim S, Laje G, Lee PH, Liu X, Loth E, Lourdusamy A, Mattingsdal M, Mohnke S, Maniega SM, Nho K, Nugent AC, O'Brien C, Papmeyer M, Pütz B, Ramasamy A, Rasmussen J, Rijpkema M, Risacher SL, Roddey JC, Rose EJ, Ryten M, Shen L, Sprooten E, Strengman E, Teumer A, Trabzuni D, Turner J, van Eijk K, van Erp TG, van Tol MJ, Wittfeld K, Wolf C, Woudstra S, Aleman A, Alhusaini S, Almasy L, Binder EB, Brohawn DG, Cantor RM, Carless MA, Corvin A, Czisch M, Curran JE, Davies G, de Almeida MA, Delanty N, Depondt C, Duggirala R, Dyer TD, Erk S, Fagerness J, Fox PT, Freimer NB, Gill M, Göring HH, Hagler DJ, Hoehn D, Holsboer F, Hoogman M, Hosten N, Jahanshad N, Johnson MP, Kasperaviciute D, Kent JW, Kochunov P, Lancaster JL, Lawrie SM, Liewald DC, Mandl R, Matarin M, Mattheisen M, Meisenzahl E, Melle I, Moses EK, Mühleisen TW, Nauck M, Nöthen MM, Olvera RL, Pandolfo M, Pike GB, Puls R, Reinvang I, Rentería ME, Rietschel M, Roffman JL, Royle NA, Rujescu D, Savitz J, Schnack HG, Schnell K, Seiferth N, Smith C, Steen VM, Valdés Hernández MC, Van den Heuvel M, van der Wee NJ, Van Haren NE, Veltman JA, Völzke H, Walker R, Westlye LT, Whelan CD, Agartz I, Boomsma DI, Cavalleri GL, Dale AM, Djurovic S, Drevets WC, Hagoort P, Hall J, Heinz A, Jack CR, Foroud TM, Le Hellard S, Macciardi F, Montgomery GW, Poline JB, Porteous DJ, Sisodiya SM, Starr JM, Sussmann J, Toga AW, Veltman DJ, Walter H, Weiner MW, Bis JC, Ikram MA, Smith AV, Gudnason V, Tzourio C, Vernooij MW, Launer LJ, DeCarli C, Seshadri S, Andreassen OA, Apostolova LG, Bastin ME, Blangero J, Brunner HG, Buckner RL, Cichon S, Coppola G, de Zubicaray GI, Deary IJ, Donohoe G, de Geus EJ, Espeseth T, Fernández G, Glahn DC, Grabe HJ, Hardy J, Hulshoff Pol HE, Jenkinson M, Kahn RS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Meyer-Lindenberg A, Morris DW, Müller-Myhsok B, Nichols TE, Ophoff RA, Paus T, Pausova Z, Penninx BW, Potkin SG, Sämann PG, Saykin AJ, Schumann G, Smoller JW, Wardlaw JM, Weale ME, Martin NG, Franke B, Wright MJ, Thompson PM. Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet. 2012 May; 44(5):552-61.View Related Profiles.

DeStefano, Anita
Seshadri, Sudha

PMID: 22504417; PMCID: PMC3635491; DOI: 10.1038/ng.2250;.

Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, Vrooman HA, Sigurdsson S, Ropele S, Taal HR, Mook-Kanamori DO, Coker LH, Longstreth WT, Niessen WJ, DeStefano AL, Beiser A, Zijdenbos AP, Struchalin M, Jack CR, Rivadeneira F, Uitterlinden AG, Knopman DS, Hartikainen AL, Pennell CE, Thiering E, Steegers EA, Hakonarson H, Heinrich J, Palmer LJ, Jarvelin MR, McCarthy MI, Grant SF, St Pourcain B, Timpson NJ, Smith GD, Sovio U, Nalls MA, Au R, Hofman A, Gudnason H, van der Lugt A, Harris TB, Meeks WM, Vernooij MW, van Buchem MA, Catellier D, Jaddoe VW, Gudnason V, Windham BG, Wolf PA, van Duijn CM, Mosley TH, Schmidt H, Launer LJ, Breteler MM, DeCarli C. Common variants at 6q22 and 17q21 are associated with intracranial volume. Nat Genet. 2012 May; 44(5):539-44.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 22504418; PMCID: PMC3618290; DOI: 10.1038/ng.2245;.

Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, Kaakinen M, Kreiner-Møller E, Bradfield JP, Freathy RM, Geller F, Guxens M, Cousminer DL, Kerkhof M, Timpson NJ, Ikram MA, Beilin LJ, Bønnelykke K, Buxton JL, Charoen P, Chawes BL, Eriksson J, Evans DM, Hofman A, Kemp JP, Kim CE, Klopp N, Lahti J, Lye SJ, McMahon G, Mentch FD, Müller-Nurasyid M, O'Reilly PF, Prokopenko I, Rivadeneira F, Steegers EA, Sunyer J, Tiesler C, Yaghootkar H, Breteler MM, Decarli C, Breteler MM, Debette S, Fornage M, Gudnason V, Launer LJ, van der Lugt A, Mosley TH, Seshadri S, Smith AV, Vernooij MW, Blakemore AI, Chiavacci RM, Feenstra B, Fernandez-Banet J, Grant SF, Hartikainen AL, van der Heijden AJ, Iñiguez C, Lathrop M, McArdle WL, Mølgaard A, Newnham JP, Palmer LJ, Palotie A, Pouta A, Ring SM, Sovio U, Standl M, Uitterlinden AG, Wichmann HE, Vissing NH, DeCarli C, van Duijn CM, McCarthy MI, Koppelman GH, Estivill X, Hattersley AT, Melbye M, Bisgaard H, Pennell CE, Widen E, Hakonarson H, Smith GD, Heinrich J, Jarvelin MR, Jaddoe VW. Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat Genet. 2012 May; 44(5):532-8.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Seshadri, Sudha

PMID: 22504419; PMCID: PMC3773913; DOI: 10.1038/ng.2238;.

Bis JC, DeCarli C, Smith AV, van der Lijn F, Crivello F, Fornage M, Debette S, Shulman JM, Schmidt H, Srikanth V, Schuur M, Yu L, Choi SH, Sigurdsson S, Verhaaren BF, DeStefano AL, Lambert JC, Jack CR, Struchalin M, Stankovich J, Ibrahim-Verbaas CA, Fleischman D, Zijdenbos A, den Heijer T, Mazoyer B, Coker LH, Enzinger C, Danoy P, Amin N, Arfanakis K, van Buchem MA, de Bruijn RF, Beiser A, Dufouil C, Huang J, Cavalieri M, Thomson R, Niessen WJ, Chibnik LB, Gislason GK, Hofman A, Pikula A, Amouyel P, Freeman KB, Phan TG, Oostra BA, Stein JL, Medland SE, Vasquez AA, Hibar DP, Wright MJ, Franke B, Martin NG, Thompson PM, Nalls MA, Uitterlinden AG, Au R, Elbaz A, Beare RJ, van Swieten JC, Lopez OL, Harris TB, Chouraki V, Breteler MM, De Jager PL, Becker JT, Vernooij MW, Knopman D, Fazekas F, Wolf PA, van der Lugt A, Gudnason V, Longstreth WT, Brown MA, Bennett DA, van Duijn CM, Mosley TH, Schmidt R, Tzourio C, Launer LJ, Ikram MA, Seshadri S. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat Genet. 2012 May; 44(5):545-51.View Related Profiles.

Pikula, Aleksandra
Beiser, Alexa
DeStefano, Anita
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 22504421; PMCID: PMC3427729; DOI: 10.1038/ng.2237;.

Pikula A, Beiser AS, DeCarli C, Himali JJ, Debette S, Au R, Selhub J, Toffler GH, Wang TJ, Meigs JB, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S. Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study. Circulation. 2012 May 1; 125(17):2100-7.View Related Profiles.

Pikula, Aleksandra
Beiser, Alexa
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Wolf, Philip
Au, Rhoda
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Ramachandran, Vasan

PMID: 22456473; PMCID: PMC3427730; DOI: 10.1161/CIRCULATIONAHA.110.989145;.

Driver JA, Beiser A, Au R, Kreger BE, Splansky GL, Kurth T, Kiel DP, Lu KP, Seshadri S, Wolf PA. Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study. BMJ. 2012; 344:e1442.View Related Profiles.

Beiser, Alexa
Kreger, Bernard
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 22411920; PMCID: PMC3647385; DOI: 10.1136/bmj.e1442;.

Tan ZS, Harris WS, Beiser AS, Au R, Himali JJ, Debette S, Pikula A, Decarli C, Wolf PA, Vasan RS, Robins SJ, Seshadri S. Red blood cell ?-3 fatty acid levels and markers of accelerated brain aging. Neurology. 2012 Feb 28; 78(9):658-64.View Related Profiles.

Pikula, Aleksandra
Beiser, Alexa
Himali, Jayandra
Wolf, Philip
Robins, Sander
Seshadri, Sudha
Ramachandran, Vasan

PMID: 22371413; PMCID: PMC3286229; DOI: 10.1212/WNL.0b013e318249f6a9;.

Hsieh YC, Seshadri S, Chung WT, Hsieh FI, Hsu YH, Lin HJ, Tseng HP, Lien LM, Bai CH, Hu CJ, Jeng JS, Tang SC, Chen CI, Yu CC, Chiou HY. Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan. J Biomed Sci. 2012; 19:1. PMID: 22212150; PMCID: PMC3269363; DOI: 10.1186/1423-0127-19-1;.

Westwood AJ, Perloff MD, McGeeney BE, Seshadri S. Constructional apraxia reversed with methylprednisolone. J Neuropsychiatry Clin Neurosci. 2012; 24(2):E51-2.View Related Profiles.

McGeeney, Brian
Perloff, Michael
Seshadri, Sudha

PMID: 22772706; DOI: 10.1176/appi.neuropsych.11060136;.

Poly C, Massaro JM, Seshadri S, Wolf PA, Cho E, Krall E, Jacques PF, Au R. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort. Am J Clin Nutr. 2011 Dec; 94(6):1584-91.View Related Profiles.

Massaro, Joseph
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 22071706; PMCID: PMC3252552; DOI: 10.3945/ajcn.110.008938;.

Barral S, Fernández-Cadenas I, Bis JC, Montaner J, Ikram AM, Launer LJ, Fornage M, Schmidt H, Brickman AM, Seshadri S, Mayeux R. No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts. Neurobiol Aging. 2012 Mar; 33(3):629.e1-3. PMID: 22074807; PMCID: PMC3259245; DOI: 10.1016/j.neurobiolaging.2011.10.010;.

Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Mateo Leach I, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJ, Dixon AL, Döring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppönen E, Janssen HL, Johnson T, Kangas AJ, Kema IP, Kühn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJ, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G, Würtz P, Xu C, Yerges-Armstrong LM, Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietiläinen KH, Schumann G, Snieder H, Sternberg MJ, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, Völzke H, Schadt EE, Scott J, Järvelin MR, Elliott P, Kooner JS. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet. 2011 Nov; 43(11):1131-8.View Related Profiles.

Cupples, L
Chen, Ming-Huei
Heard-Costa, Nancy
Seshadri, Sudha
Ramachandran, Vasan

PMID: 22001757; PMCID: PMC3482372; DOI: 10.1038/ng.970;.

Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH, Aulchenko Y, Heath S, Sõber S, Parsa A, Luan J, Arora P, Dehghan A, Zhang F, Lucas G, Hicks AA, Jackson AU, Peden JF, Tanaka T, Wild SH, Rudan I, Igl W, Milaneschi Y, Parker AN, Fava C, Chambers JC, Fox ER, Kumari M, Go MJ, van der Harst P, Kao WH, Sjögren M, Vinay DG, Alexander M, Tabara Y, Shaw-Hawkins S, Whincup PH, Liu Y, Shi G, Kuusisto J, Tayo B, Seielstad M, Sim X, Nguyen KD, Lehtimäki T, Matullo G, Wu Y, Gaunt TR, Onland-Moret NC, Cooper MN, Platou CG, Org E, Hardy R, Dahgam S, Palmen J, Vitart V, Braund PS, Kuznetsova T, Uiterwaal CS, Adeyemo A, Palmas W, Campbell H, Ludwig B, Tomaszewski M, Tzoulaki I, Palmer ND, Aspelund T, Garcia M, Chang YP, O'Connell JR, Steinle NI, Grobbee DE, Arking DE, Kardia SL, Morrison AC, Hernandez D, Najjar S, McArdle WL, Hadley D, Brown MJ, Connell JM, Hingorani AD, Day IN, Lawlor DA, Beilby JP, Lawrence RW, Clarke R, Hopewell JC, Ongen H, Dreisbach AW, Li Y, Young JH, Bis JC, Kähönen M, Viikari J, Adair LS, Lee NR, Chen MH, Olden M, Pattaro C, Bolton JA, Köttgen A, Bergmann S, Mooser V, Chaturvedi N, Frayling TM, Islam M, Jafar TH, Erdmann J, Kulkarni SR, Bornstein SR, Grässler J, Groop L, Voight BF, Kettunen J, Howard P, Taylor A, Guarrera S, Ricceri F, Emilsson V, Plump A, Barroso I, Khaw KT, Weder AB, Hunt SC, Sun YV, Bergman RN, Collins FS, Bonnycastle LL, Scott LJ, Stringham HM, Peltonen L, Perola M, Vartiainen E, Brand SM, Staessen JA, Wang TJ, Burton PR, Soler Artigas M, Dong Y, Snieder H, Wang X, Zhu H, Lohman KK, Rudock ME, Heckbert SR, Smith NL, Wiggins KL, Doumatey A, Shriner D, Veldre G, Viigimaa M, Kinra S, Prabhakaran D, Tripathy V, Langefeld CD, Rosengren A, Thelle DS, Corsi AM, Singleton A, Forrester T, Hilton G, McKenzie CA, Salako T, Iwai N, Kita Y, Ogihara T, Ohkubo T, Okamura T, Ueshima H, Umemura S, Eyheramendy S, Meitinger T, Wichmann HE, Cho YS, Kim HL, Lee JY, Scott J, Sehmi JS, Zhang W, Hedblad B, Nilsson P, Smith GD, Wong A, Narisu N, Stancáková A, Raffel LJ, Yao J, Kathiresan S, O'Donnell CJ, Schwartz SM, Ikram MA, Longstreth WT, Mosley TH, Seshadri S, Shrine NR, Wain LV, Morken MA, Swift AJ, Laitinen J, Prokopenko I, Zitting P, Cooper JA, Humphries SE, Danesh J, Rasheed A, Goel A, Hamsten A, Watkins H, Bakker SJ, van Gilst WH, Janipalli CS, Mani KR, Yajnik CS, Hofman A, Mattace-Raso FU, Oostra BA, Demirkan A, Isaacs A, Rivadeneira F, Lakatta EG, Orru M, Scuteri A, Ala-Korpela M, Kangas AJ, Lyytikäinen LP, Soininen P, Tukiainen T, Würtz P, Ong RT, Dörr M, Kroemer HK, Völker U, Völzke H, Galan P, Hercberg S, Lathrop M, Zelenika D, Deloukas P, Mangino M, Spector TD, Zhai G, Meschia JF, Nalls MA, Sharma P, Terzic J, Kumar MV, Denniff M, Zukowska-Szczechowska E, Wagenknecht LE, Fowkes FG, Charchar FJ, Schwarz PE, Hayward C, Guo X, Rotimi C, Bots ML, Brand E, Samani NJ, Polasek O, Talmud PJ, Nyberg F, Kuh D, Laan M, Hveem K, Palmer LJ, van der Schouw YT, Casas JP, Mohlke KL, Vineis P, Raitakari O, Ganesh SK, Wong TY, Tai ES, Cooper RS, Laakso M, Rao DC, Harris TB, Morris RW, Dominiczak AF, Kivimaki M, Marmot MG, Miki T, Saleheen D, Chandak GR, Coresh J, Navis G, Salomaa V, Han BG, Zhu X, Kooner JS, Melander O, Ridker PM, Bandinelli S, Gyllensten UB, Wright AF, Wilson JF, Ferrucci L, Farrall M, Tuomilehto J, Pramstaller PP, Elosua R, Soranzo N, Sijbrands EJ, Altshuler D, Loos RJ, Shuldiner AR, Gieger C, Meneton P, Uitterlinden AG, Wareham NJ, Gudnason V, Rotter JI, Rettig R, Uda M, Strachan DP, Witteman JC, Hartikainen AL, Beckmann JS, Boerwinkle E, Vasan RS, Boehnke M, Larson MG, Järvelin MR, Psaty BM, Abecasis GR, Chakravarti A, Elliott P, van Duijn CM, Newton-Cheh C, Levy D, Caulfield MJ, Johnson T. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Oct 6; 478(7367):103-9.View Related Profiles.

Cupples, L
Larson, Martin
Chen, Ming-Huei
Myers, Richard
Hwang, Shih-Jen
Seshadri, Sudha
Ramachandran, Vasan

PMID: 21909115; PMCID: PMC3340926; DOI: 10.1038/nature10405;.

Jefferson AL, Himali JJ, Au R, Seshadri S, Decarli C, O'Donnell CJ, Wolf PA, Manning WJ, Beiser AS, Benjamin EJ. Relation of left ventricular ejection fraction to cognitive aging (from the Framingham Heart Study). Am J Cardiol. 2011 Nov 1; 108(9):1346-51.View Related Profiles.

Beiser, Alexa
Benjamin, Emelia
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 21880293; PMCID: PMC3204899; DOI: 10.1016/j.amjcard.2011.06.056;.

Schnabel RB, Kerr KF, Lubitz SA, Alkylbekova EL, Marcus GM, Sinner MF, Magnani JW, Wolf PA, Deo R, Lloyd-Jones DM, Lunetta KL, Mehra R, Levy D, Fox ER, Arking DE, Mosley TH, Müller-Nurasyid M, Young TR, Wichmann HE, Seshadri S, Farlow DN, Rotter JI, Soliman EZ, Glazer NL, Wilson JG, Breteler MM, Sotoodehnia N, Newton-Cheh C, Kääb S, Ellinor PT, Alonso A, Benjamin EJ, Heckbert SR. Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project. Circ Cardiovasc Genet. 2011 Oct; 4(5):557-64.View Related Profiles.

Benjamin, Emelia
Magnani, Jared
Lunetta, Kathryn
Wolf, Philip
Seshadri, Sudha

PMID: 21846873; PMCID: PMC3224824; DOI: 10.1161/CIRCGENETICS.110.959197;.

Zade D, Beiser A, McGlinchey R, Au R, Seshadri S, Palumbo C, Wolf PA, DeCarli C, Milberg W. Apolipoprotein epsilon 4 allele modifies waist-to-hip ratio effects on cognition and brain structure. J Stroke Cerebrovasc Dis. 2013 Feb; 22(2):119-25.View Related Profiles.

Beiser, Alexa
Palumbo, Carole
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Milberg, William

PMID: 21835633; PMCID: PMC3613758; DOI: 10.1016/j.jstrokecerebrovasdis.2011.06.020;.

Debette S, Seshadri S, Beiser A, Au R, Himali JJ, Palumbo C, Wolf PA, DeCarli C. Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline. Neurology. 2011 Aug 2; 77(5):461-8.View Related Profiles.

Beiser, Alexa
Palumbo, Carole
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 21810696; PMCID: PMC3146307; DOI: 10.1212/WNL.0b013e318227b227;.

Walter S, Atzmon G, Demerath EW, Garcia ME, Kaplan RC, Kumari M, Lunetta KL, Milaneschi Y, Tanaka T, Tranah GJ, Völker U, Yu L, Arnold A, Benjamin EJ, Biffar R, Buchman AS, Boerwinkle E, Couper D, De Jager PL, Evans DA, Harris TB, Hoffmann W, Hofman A, Karasik D, Kiel DP, Kocher T, Kuningas M, Launer LJ, Lohman KK, Lutsey PL, Mackenbach J, Marciante K, Psaty BM, Reiman EM, Rotter JI, Seshadri S, Shardell MD, Smith AV, van Duijn C, Walston J, Zillikens MC, Bandinelli S, Baumeister SE, Bennett DA, Ferrucci L, Gudnason V, Kivimaki M, Liu Y, Murabito JM, Newman AB, Tiemeier H, Franceschini N. A genome-wide association study of aging. Neurobiol Aging. 2011 Nov; 32(11):2109.e15-28.View Related Profiles.

Benjamin, Emelia
Murabito, Joanne
Lunetta, Kathryn
Seshadri, Sudha

PMID: 21782286; PMCID: PMC3193030; DOI: 10.1016/j.neurobiolaging.2011.05.026;.

Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke. 2011 Sep; 42(9):2672-713. PMID: 21778438; PMCID: PMC3778669; DOI: 10.1161/STR.0b013e3182299496;.

Debette S, Visvikis-Siest S, Chen MH, Ndiaye NC, Song C, Destefano A, Safa R, Azimi Nezhad M, Sawyer D, Marteau JB, Xanthakis V, Siest G, Sullivan L, Pfister M, Smith H, Choi SH, Lamont J, Lind L, Yang Q, Fitzgerald P, Ingelsson E, Vasan RS, Seshadri S. Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels. Circ Res. 2011 Aug 19; 109(5):554-63.View Related Profiles.

DeStefano, Anita
Sullivan, Lisa
Yang, Qiong
Seshadri, Sudha
Xanthakis, Vanessa
Ramachandran, Vasan

PMID: 21757650; PMCID: PMC3193930; DOI: 10.1161/CIRCRESAHA.111.243790;.

Jefferson AL, Massaro JM, Beiser AS, Seshadri S, Larson MG, Wolf PA, Au R, Benjamin EJ. Inflammatory markers and neuropsychological functioning: the Framingham Heart Study. Neuroepidemiology. 2011; 37(1):21-30.View Related Profiles.

Beiser, Alexa
Benjamin, Emelia
Massaro, Joseph
Larson, Martin
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 21757961; PMCID: PMC3142099; DOI: 10.1159/000328864;.

Tan ZS, Beiser AS, Fox CS, Au R, Himali JJ, Debette S, Decarli C, Vasan RS, Wolf PA, Seshadri S. Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study. Diabetes Care. 2011 Aug; 34(8):1766-70.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Ramachandran, Vasan

PMID: 21680719; PMCID: PMC3142014; DOI: 10.2337/dc11-0308;.

Fornage M, Debette S, Bis JC, Schmidt H, Ikram MA, Dufouil C, Sigurdsson S, Lumley T, DeStefano AL, Fazekas F, Vrooman HA, Shibata DK, Maillard P, Zijdenbos A, Smith AV, Gudnason H, de Boer R, Cushman M, Mazoyer B, Heiss G, Vernooij MW, Enzinger C, Glazer NL, Beiser A, Knopman DS, Cavalieri M, Niessen WJ, Harris TB, Petrovic K, Lopez OL, Au R, Lambert JC, Hofman A, Gottesman RF, Garcia M, Heckbert SR, Atwood LD, Catellier DJ, Uitterlinden AG, Yang Q, Smith NL, Aspelund T, Romero JR, Rice K, Taylor KD, Nalls MA, Rotter JI, Sharrett R, van Duijn CM, Amouyel P, Wolf PA, Gudnason V, van der Lugt A, Boerwinkle E, Psaty BM, Seshadri S, Tzourio C, Breteler MM, Mosley TH, Schmidt R, Longstreth WT, DeCarli C, Launer LJ. Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Ann Neurol. 2011 Jun; 69(6):928-39.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Romero, Jose
Glazer, Nicole
Wolf, Philip
Yang, Qiong
Au, Rhoda
Seshadri, Sudha

PMID: 21681796; PMCID: PMC3122147; DOI: 10.1002/ana.22403;.

Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Beaumont H, Warden D, Wilcock G, Love S, Kehoe PG, Hooper NM, Vardy ER, Hardy J, Mead S, Fox NC, Rossor M, Collinge J, Maier W, Jessen F, Rüther E, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Gallacher J, Hüll M, Rujescu D, Giegling I, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Pankratz VS, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen RC, van Duijn CM, Breteler MM, Ikram MA, DeStefano AL, Fitzpatrick AL, Lopez O, Launer LJ, Seshadri S, Berr C, Campion D, Epelbaum J, Dartigues JF, Tzourio C, Alpérovitch A, Lathrop M, Feulner TM, Friedrich P, Riehle C, Krawczak M, Schreiber S, Mayhaus M, Nicolhaus S, Wagenpfeil S, Steinberg S, Stefansson H, Stefansson K, Snaedal J, Björnsson S, Jonsson PV, Chouraki V, Genier-Boley B, Hiltunen M, Soininen H, Combarros O, Zelenika D, Delepine M, Bullido MJ, Pasquier F, Mateo I, Frank-Garcia A, Porcellini E, Hanon O, Coto E, Alvarez V, Bosco P, Siciliano G, Mancuso M, Panza F, Solfrizzi V, Nacmias B, Sorbi S, Bossù P, Piccardi P, Arosio B, Annoni G, Seripa D, Pilotto A, Scarpini E, Galimberti D, Brice A, Hannequin D, Licastro F, Jones L, Holmans PA, Jonsson T, Riemenschneider M, Morgan K, Younkin SG, Owen MJ, O'Donovan M, Amouyel P, Williams J. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet. 2011 May; 43(5):429-35.View Related Profiles.

DeStefano, Anita
Seshadri, Sudha

PMID: 21460840; PMCID: PMC3084173; DOI: 10.1038/ng.803;.

Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, Ramachandran VS, Polak JF, Fabsitz RR, Dries DL, Farlow DN, Redline S, Adeyemo A, Hirschorn JN, Sun YV, Wyatt SB, Penman AD, Palmas W, Rotter JI, Townsend RR, Doumatey AP, Tayo BO, Mosley TH, Lyon HN, Kang SJ, Rotimi CN, Cooper RS, Franceschini N, Curb JD, Martin LW, Eaton CB, Kardia SL, Taylor HA, Caulfield MJ, Ehret GB, Johnson T, Chakravarti A, Zhu X, Levy D. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet. 2011 Jun 1; 20(11):2273-84.View Related Profiles.

Chen, Ming-Huei
Glazer, Nicole
Seshadri, Sudha
Ramachandran, Vasan

PMID: 21378095; PMCID: PMC3090190; DOI: 10.1093/hmg/ddr092;.

Seshadri S, Beiser A, Au R, Wolf PA, Evans DA, Wilson RS, Petersen RC, Knopman DS, Rocca WA, Kawas CH, Corrada MM, Plassman BL, Langa KM, Chui HC. Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2. Alzheimers Dement. 2011 Jan; 7(1):35-52.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 21255742; PMCID: PMC3039838; DOI: 10.1016/j.jalz.2010.12.002;.

Broer L, Ikram MA, Schuur M, DeStefano AL, Bis JC, Liu F, Rivadeneira F, Uitterlinden AG, Beiser AS, Longstreth WT, Hofman A, Aulchenko Y, Seshadri S, Fitzpatrick AL, Oostra BA, Breteler MM, van Duijn CM. Association of HSP70 and its co-chaperones with Alzheimer's disease. J Alzheimers Dis. 2011; 25(1):93-102.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Seshadri, Sudha

PMID: 21403392; PMCID: PMC3483142; DOI: 10.3233/JAD-2011-101560;.

Seshadri S. Beauty and the beast: B12, homocysteine, and the brain: a bemusing saga! Neurology. 2010 Oct 19; 75(16):1402-3. PMID: 20956785; DOI: 10.1212/WNL.0b013e3181f8836f;.

Kao PF, Davis DA, Banigan MG, Vanderburg CR, Seshadri S, Delalle I. Modulators of cytoskeletal reorganization in CA1 hippocampal neurons show increased expression in patients at mid-stage Alzheimer's disease. PLoS One. 2010; 5(10):e13337.View Related Profiles.

Delalle, Ivana
Seshadri, Sudha

PMID: 20967212; PMCID: PMC2954170; DOI: 10.1371/journal.pone.0013337;.

Jefferson AL, Himali JJ, Beiser AS, Au R, Massaro JM, Seshadri S, Gona P, Salton CJ, DeCarli C, O'Donnell CJ, Benjamin EJ, Wolf PA, Manning WJ. Cardiac index is associated with brain aging: the Framingham Heart Study. Circulation. 2010 Aug 17; 122(7):690-7.View Related Profiles.

Beiser, Alexa
Jefferson, Angela
Benjamin, Emelia
Himali, Jayandra
Massaro, Joseph
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 20679552; PMCID: PMC2929763; DOI: 10.1161/CIRCULATIONAHA.109.905091;.

Debette S, Beiser A, Hoffmann U, Decarli C, O'Donnell CJ, Massaro JM, Au R, Himali JJ, Wolf PA, Fox CS, Seshadri S. Visceral fat is associated with lower brain volume in healthy middle-aged adults. Ann Neurol. 2010 Aug; 68(2):136-44.View Related Profiles.

Beiser, Alexa
Himali, Jayandra
Massaro, Joseph
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 20695006; PMCID: PMC2933649; DOI: 10.1002/ana.22062;.

Saczynski JS, Beiser A, Seshadri S, Auerbach S, Wolf PA, Au R. Depressive symptoms and risk of dementia: the Framingham Heart Study. Neurology. 2010 Jul 6; 75(1):35-41.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
Auerbach, Sanford
Seshadri, Sudha

PMID: 20603483; PMCID: PMC2906404; DOI: 10.1212/WNL.0b013e3181e62138;.

Stavitsky K, Du Y, Seichepine D, Laudate TM, Beiser A, Seshadri S, Decarli C, Wolf PA, Au R. White matter hyperintensity and cognitive functioning in the racial and ethnic minority cohort of the Framingham Heart Study. Neuroepidemiology. 2010 Aug; 35(2):117-22.View Related Profiles.

Beiser, Alexa
Seichepine, Daniel
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 20551699; PMCID: PMC2945265; DOI: 10.1159/000313443;.

Zade D, Beiser A, McGlinchey R, Au R, Seshadri S, Palumbo C, Wolf PA, Decarli C, Milberg W. Interactive effects of apolipoprotein E type 4 genotype and cerebrovascular risk on neuropsychological performance and structural brain changes. J Stroke Cerebrovasc Dis. 2010 Jul-Aug; 19(4):261-8.View Related Profiles.

Beiser, Alexa
Palumbo, Carole
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Milberg, William

PMID: 20471857; PMCID: PMC2900511; DOI: 10.1016/j.jstrokecerebrovasdis.2009.05.001;.

Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M, Bis JC, Smith AV, Carassquillo MM, Lambert JC, Harold D, Schrijvers EM, Ramirez-Lorca R, Debette S, Longstreth WT, Janssens AC, Pankratz VS, Dartigues JF, Hollingworth P, Aspelund T, Hernandez I, Beiser A, Kuller LH, Koudstaal PJ, Dickson DW, Tzourio C, Abraham R, Antunez C, Du Y, Rotter JI, Aulchenko YS, Harris TB, Petersen RC, Berr C, Owen MJ, Lopez-Arrieta J, Varadarajan BN, Becker JT, Rivadeneira F, Nalls MA, Graff-Radford NR, Campion D, Auerbach S, Rice K, Hofman A, Jonsson PV, Schmidt H, Lathrop M, Mosley TH, Au R, Psaty BM, Uitterlinden AG, Farrer LA, Lumley T, Ruiz A, Williams J, Amouyel P, Younkin SG, Wolf PA, Launer LJ, Lopez OL, van Duijn CM, Breteler MM. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA. 2010 May 12; 303(18):1832-40.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Farrer, Lindsay
Wolf, Philip
Au, Rhoda
Auerbach, Sanford
Seshadri, Sudha

PMID: 20460622; PMCID: PMC2989531; DOI: 10.1001/jama.2010.574;.

Tan ZS, Seshadri S. Inflammation in the Alzheimer's disease cascade: culprit or innocent bystander? Alzheimers Res Ther. 2010; 2(2):6. PMID: 20388190; PMCID: PMC2876784; DOI: 10.1186/alzrt29;.

Albert M, Massaro J, DeCarli C, Beiser A, Seshadri S, Wolf PA, Au R. Profiles by sex of brain MRI and cognitive function in the framingham offspring study. Alzheimer Dis Assoc Disord. 2010 Apr-Jun; 24(2):190-3.View Related Profiles.

Beiser, Alexa
Massaro, Joseph
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 20505436; PMCID: PMC2879078; DOI: 10.1097/WAD.0b013e3181c1ed44;.

Newman AB, Walter S, Lunetta KL, Garcia ME, Slagboom PE, Christensen K, Arnold AM, Aspelund T, Aulchenko YS, Benjamin EJ, Christiansen L, D'Agostino RB, Fitzpatrick AL, Franceschini N, Glazer NL, Gudnason V, Hofman A, Kaplan R, Karasik D, Kelly-Hayes M, Kiel DP, Launer LJ, Marciante KD, Massaro JM, Miljkovic I, Nalls MA, Hernandez D, Psaty BM, Rivadeneira F, Rotter J, Seshadri S, Smith AV, Taylor KD, Tiemeier H, Uh HW, Uitterlinden AG, Vaupel JW, Walston J, Westendorp RG, Harris TB, Lumley T, van Duijn CM, Murabito JM. A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. J Gerontol A Biol Sci Med Sci. 2010 May; 65(5):478-87.View Related Profiles.

Benjamin, Emelia
Murabito, Joanne
Massaro, Joseph
Lunetta, Kathryn
Kelly-Hayes, Margaret
Glazer, Nicole
D'Agostino, Ralph
Seshadri, Sudha

PMID: 20304771; PMCID: PMC2854887; DOI: 10.1093/gerona/glq028;.

Seshadri S, Beiser A, Pikula A, Himali JJ, Kelly-Hayes M, Debette S, DeStefano AL, Romero JR, Kase CS, Wolf PA. Parental occurrence of stroke and risk of stroke in their children: the Framingham study. Circulation. 2010 Mar 23; 121(11):1304-12.View Related Profiles.

Pikula, Aleksandra
Beiser, Alexa
DeStefano, Anita
Kase, Carlos
Himali, Jayandra
Romero, Jose
Kelly-Hayes, Margaret
Wolf, Philip
Seshadri, Sudha

PMID: 20212282; PMCID: PMC2860311; DOI: 10.1161/CIRCULATIONAHA.109.854240;.

Debette S, Beiser A, DeCarli C, Au R, Himali JJ, Kelly-Hayes M, Romero JR, Kase CS, Wolf PA, Seshadri S. Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study. Stroke. 2010 Apr; 41(4):600-6.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Himali, Jayandra
Romero, Jose
Kelly-Hayes, Margaret
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 20167919; PMCID: PMC2847685; DOI: 10.1161/STROKEAHA.109.570044;.

Seshadri S. Understanding the link between obesity and dementia in older adults. Aging Health. Dec. 2010; 6:663-665. View Publication

Debette S, Bis JC, Fornage M, Schmidt H, Ikram MA, Sigurdsson S, Heiss G, Struchalin M, Smith AV, van der Lugt A, DeCarli C, Lumley T, Knopman DS, Enzinger C, Eiriksdottir G, Koudstaal PJ, DeStefano AL, Psaty BM, Dufouil C, Catellier DJ, Fazekas F, Aspelund T, Aulchenko YS, Beiser A, Rotter JI, Tzourio C, Shibata DK, Tscherner M, Harris TB, Rivadeneira F, Atwood LD, Rice K, Gottesman RF, van Buchem MA, Uitterlinden AG, Kelly-Hayes M, Cushman M, Zhu Y, Boerwinkle E, Gudnason V, Hofman A, Romero JR, Lopez O, van Duijn CM, Au R, Heckbert SR, Wolf PA, Mosley TH, Seshadri S, Breteler MM, Schmidt R, Launer LJ, Longstreth WT. Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium. Stroke. 2010 Feb; 41(2):210-7.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Romero, Jose
Atwood, Larry
Kelly-Hayes, Margaret
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 20044523; PMCID: PMC2923092; DOI: 10.1161/STROKEAHA.109.569194;.

Lieb W, Beiser AS, Vasan RS, Tan ZS, Au R, Harris TB, Roubenoff R, Auerbach S, DeCarli C, Wolf PA, Seshadri S. Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA. 2009 Dec 16; 302(23):2565-72.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
Auerbach, Sanford
Seshadri, Sudha
Ramachandran, Vasan

PMID: 20009056; PMCID: PMC2838501; DOI: 10.1001/jama.2009.1836;.

Debette S, Wolf PA, Beiser A, Au R, Himali JJ, Pikula A, Auerbach S, Decarli C, Seshadri S. Association of parental dementia with cognitive and brain MRI measures in middle-aged adults. Neurology. 2009 Dec 15; 73(24):2071-8.View Related Profiles.

Pikula, Aleksandra
Beiser, Alexa
Himali, Jayandra
Wolf, Philip
Au, Rhoda
Auerbach, Sanford
Seshadri, Sudha

PMID: 20007524; PMCID: PMC2790222; DOI: 10.1212/WNL.0b013e3181c67833;.

Debette S, Seshadri S. Vascular risk factors and dementia revisited. J Neurol Neurosurg Psychiatry. 2009 Nov; 80(11):1183-4. PMID: 19864653; PMCID: PMC2837356; DOI: 10.1136/jnnp.2009.181289;.

Pikula A, Böger RH, Beiser AS, Maas R, DeCarli C, Schwedhelm E, Himali JJ, Schulze F, Au R, Kelly-Hayes M, Kase CS, Vasan RS, Wolf PA, Seshadri S. Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study. Stroke. 2009 Sep; 40(9):2959-64.View Related Profiles.

Pikula, Aleksandra
Beiser, Alexa
Kase, Carlos
Himali, Jayandra
Kelly-Hayes, Margaret
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Ramachandran, Vasan

PMID: 19644064; PMCID: PMC2749945; DOI: 10.1161/STROKEAHA.109.557116;.

DeStefano AL, Seshadri S, Beiser A, Atwood LD, Massaro JM, Au R, Wolf PA, DeCarli C. Bivariate heritability of total and regional brain volumes: the Framingham Study. Alzheimer Dis Assoc Disord. 2009 Jul-Sep; 23(3):218-23.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Atwood, Larry
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 19812462; PMCID: PMC2760008; DOI: 10.1097/WAD.0b013e31819cadd8;.

Maas R, Xanthakis V, Polak JF, Schwedhelm E, Sullivan LM, Benndorf R, Schulze F, Vasan RS, Wolf PA, Böger RH, Seshadri S. Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the Framingham Heart Study offspring cohort. Stroke. 2009 Aug; 40(8):2715-9.View Related Profiles.

Sullivan, Lisa
Wolf, Philip
Seshadri, Sudha
Xanthakis, Vanessa
Ramachandran, Vasan

PMID: 19498184; PMCID: PMC2749947; DOI: 10.1161/STROKEAHA.109.552539;.

Ikram MA, Seshadri S, Bis JC, Fornage M, DeStefano AL, Aulchenko YS, Debette S, Lumley T, Folsom AR, van den Herik EG, Bos MJ, Beiser A, Cushman M, Launer LJ, Shahar E, Struchalin M, Du Y, Glazer NL, Rosamond WD, Rivadeneira F, Kelly-Hayes M, Lopez OL, Coresh J, Hofman A, DeCarli C, Heckbert SR, Koudstaal PJ, Yang Q, Smith NL, Kase CS, Rice K, Haritunians T, Roks G, de Kort PL, Taylor KD, de Lau LM, Oostra BA, Uitterlinden AG, Rotter JI, Boerwinkle E, Psaty BM, Mosley TH, van Duijn CM, Breteler MM, Longstreth WT, Wolf PA. Genomewide association studies of stroke. N Engl J Med. 2009 Apr 23; 360(17):1718-28.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Kase, Carlos
Kelly-Hayes, Margaret
Glazer, Nicole
Wolf, Philip
Yang, Qiong
Seshadri, Sudha

PMID: 19369658; PMCID: PMC2768348; DOI: 10.1056/NEJMoa0900094;.

Debette S, Seshadri S. Genetics of atherothrombotic and lacunar stroke. Circ Cardiovasc Genet. 2009 Apr; 2(2):191-8. PMID: 20031584; PMCID: PMC2798146; DOI: 10.1161/CIRCGENETICS.108.828319;.

Romero JR, Beiser A, Seshadri S, Benjamin EJ, Polak JF, Vasan RS, Au R, DeCarli C, Wolf PA. Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study. Stroke. 2009 May; 40(5):1590-6.View Related Profiles.

Beiser, Alexa
Benjamin, Emelia
Romero, Jose
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Ramachandran, Vasan

PMID: 19265054; PMCID: PMC2705324; DOI: 10.1161/STROKEAHA.108.535245;.

Petrea RE, Beiser AS, Seshadri S, Kelly-Hayes M, Kase CS, Wolf PA. Gender differences in stroke incidence and poststroke disability in the Framingham heart study. Stroke. 2009 Apr; 40(4):1032-7.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Kelly-Hayes, Margaret
Wolf, Philip
Seshadri, Sudha

PMID: 19211484; PMCID: PMC2676725; DOI: 10.1161/STROKEAHA.108.542894;.

Romero JR, Vasan RS, Beiser AS, Au R, Benjamin EJ, DeCarli C, Wolf PA, Seshadri S. Association of matrix metalloproteinases with MRI indices of brain ischemia and aging. Neurobiol Aging. 2010 Dec; 31(12):2128-35.View Related Profiles.

Beiser, Alexa
Benjamin, Emelia
Romero, Jose
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Ramachandran, Vasan

PMID: 19128858; PMCID: PMC2891210; DOI: 10.1016/j.neurobiolaging.2008.11.004;.

Das RR, Seshadri S. Diabetes and Stroke. Current Cardiovascular Risk Reports. 2009; 3:35-41. View Publication

Romero JR, Vasan RS, Beiser AS, Polak JF, Benjamin EJ, Wolf PA, Seshadri S. Association of carotid artery atherosclerosis with circulating biomarkers of extracellular matrix remodeling: the Framingham Offspring Study. J Stroke Cerebrovasc Dis. 2008 Nov-Dec; 17(6):412-7.View Related Profiles.

Beiser, Alexa
Benjamin, Emelia
Romero, Jose
Wolf, Philip
Seshadri, Sudha
Ramachandran, Vasan

PMID: 18984437; PMCID: PMC2613480; DOI: 10.1016/j.jstrokecerebrovasdis.2008.06.002;.

Paul CA, Au R, Fredman L, Massaro JM, Seshadri S, Decarli C, Wolf PA. Association of alcohol consumption with brain volume in the Framingham study. Arch Neurol. 2008 Oct; 65(10):1363-7.View Related Profiles.

Massaro, Joseph
Fredman, Lisa
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 18852353; PMCID: PMC2861346; DOI: 10.1001/archneur.65.10.1363;.

Tan ZS, Beiser A, Vasan RS, Au R, Auerbach S, Kiel DP, Wolf PA, Seshadri S. Thyroid function and the risk of Alzheimer disease: the Framingham Study. Arch Intern Med. 2008 Jul 28; 168(14):1514-20.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
Auerbach, Sanford
Seshadri, Sudha
Ramachandran, Vasan

PMID: 18663163; PMCID: PMC2694610; DOI: 10.1001/archinte.168.14.1514;.

Das RR, Seshadri S, Beiser AS, Kelly-Hayes M, Au R, Himali JJ, Kase CS, Benjamin EJ, Polak JF, O'Donnell CJ, Yoshita M, D'Agostino RB, DeCarli C, Wolf PA. Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study. Stroke. 2008 Nov; 39(11):2929-35.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Benjamin, Emelia
Himali, Jayandra
Kelly-Hayes, Margaret
Wolf, Philip
D'Agostino, Ralph
Au, Rhoda
Seshadri, Sudha

PMID: 18583555; PMCID: PMC2712254; DOI: 10.1161/STROKEAHA.108.516575;.

Seshadri S, Wolf PA, Beiser AS, Selhub J, Au R, Jacques PF, Yoshita M, Rosenberg IH, D'Agostino RB, DeCarli C. Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study. Arch Neurol. 2008 May; 65(5):642-9.View Related Profiles.

Beiser, Alexa
Wolf, Philip
D'Agostino, Ralph
Au, Rhoda
Seshadri, Sudha

PMID: 18474741; PMCID: PMC2700952; DOI: 10.1001/archneur.65.5.642;.

Seshadri S, Wolf PA. Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study. Lancet Neurol. 2007 Dec; 6(12):1106-14.View Related Profiles.

Wolf, Philip
Seshadri, Sudha

PMID: 18031707.

Lunetta KL, D'Agostino RB, Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel DP, Kelly-Hayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. BMC Med Genet. 2007; 8 Suppl 1:S13.View Related Profiles.

Benjamin, Emelia
Murabito, Joanne
Massaro, Joseph
Lunetta, Kathryn
Kelly-Hayes, Margaret
Pencina, Michael
D'Agostino, Ralph
Seshadri, Sudha

PMID: 17903295; PMCID: PMC1995604.

Seshadri S, DeStefano AL, Au R, Massaro JM, Beiser AS, Kelly-Hayes M, Kase CS, D'Agostino RB, Decarli C, Atwood LD, Wolf PA. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. BMC Med Genet. 2007; 8 Suppl 1:S15.View Related Profiles.

Beiser, Alexa
DeStefano, Anita
Kase, Carlos
Massaro, Joseph
Kelly-Hayes, Margaret
Wolf, Philip
D'Agostino, Ralph
Au, Rhoda
Seshadri, Sudha

PMID: 17903297; PMCID: PMC1995608.

Larson MG, Atwood LD, Benjamin EJ, Cupples LA, D'Agostino RB, Fox CS, Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Murabito JM, Newton-Cheh C, O'Donnell CJ, Seshadri S, Vasan RS, Wang TJ, Wolf PA, Levy D. Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. BMC Med Genet. 2007; 8 Suppl 1:S5.View Related Profiles.

Benjamin, Emelia
Murabito, Joanne
Cupples, L
Larson, Martin
Heard-Costa, Nancy
Wolf, Philip
D'Agostino, Ralph
Hwang, Shih-Jen
Seshadri, Sudha
Ramachandran, Vasan

PMID: 17903304; PMCID: PMC1995607.

Tan ZS, Beiser AS, Vasan RS, Roubenoff R, Dinarello CA, Harris TB, Benjamin EJ, Au R, Kiel DP, Wolf PA, Seshadri S. Inflammatory markers and the risk of Alzheimer disease: the Framingham Study. Neurology. 2007 May 29; 68(22):1902-8.View Related Profiles.

Beiser, Alexa
Benjamin, Emelia
Wolf, Philip
Seshadri, Sudha
Ramachandran, Vasan

PMID: 17536046.

Wolf PA, Beiser A, Elias MF, Au R, Vasan RS, Seshadri S. Relation of obesity to cognitive function: importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart Study. Curr Alzheimer Res. 2007 Apr; 4(2):111-6.View Related Profiles.

Beiser, Alexa
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Ramachandran, Vasan

PMID: 17430232.

Jefferson AL, Massaro JM, Wolf PA, Seshadri S, Au R, Vasan RS, Larson MG, Meigs JB, Keaney JF, Lipinska I, Kathiresan S, Benjamin EJ, DeCarli C. Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study. Neurology. 2007 Mar 27; 68(13):1032-8.View Related Profiles.

Benjamin, Emelia
Massaro, Joseph
Larson, Martin
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Ramachandran, Vasan

PMID: 17389308; PMCID: PMC2758770.

Elias MF, Sullivan LM, Elias PK, D'Agostino RB, Wolf PA, Seshadri S, Au R, Benjamin EJ, Vasan RS. Left ventricular mass, blood pressure, and lowered cognitive performance in the Framingham offspring. Hypertension. 2007 Mar; 49(3):439-45.View Related Profiles.

Benjamin, Emelia
Sullivan, Lisa
Wolf, Philip
D'Agostino, Ralph
Au, Rhoda
Seshadri, Sudha
Ramachandran, Vasan

PMID: 17224472.

Cupples LA, Arruda HT, Benjamin EJ, D'Agostino RB, Demissie S, DeStefano AL, Dupuis J, Falls KM, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Kathiresan S, Kiel DP, Laramie JM, Larson MG, Levy D, Liu CY, Lunetta KL, Mailman MD, Manning AK, Meigs JB, Murabito JM, Newton-Cheh C, O'Connor GT, O'Donnell CJ, Pandey M, Seshadri S, Vasan RS, Wang ZY, Wilk JB, Wolf PA, Yang Q, Atwood LD. The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet. 2007; 8 Suppl 1:S1.View Related Profiles.

DeStefano, Anita
Liu, Chunyu
Benjamin, Emelia
O'Connor, George
Murabito, Joanne
Dupuis, Josee
Lunetta, Kathryn
Cupples, L
Larson, Martin
Heard-Costa, Nancy
Wolf, Philip
Yang, Qiong
D'Agostino, Ralph
Demissie, Serkalem
Hwang, Shih-Jen
Seshadri, Sudha
Ramachandran, Vasan

PMID: 17903291; PMCID: PMC1995613.

Carandang R, Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Kannel WB, Wolf PA. Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years. JAMA. 2006 Dec 27; 296(24):2939-46.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Kelly-Hayes, Margaret
Wolf, Philip
Seshadri, Sudha

PMID: 17190894.

Akomolafe A, Beiser A, Meigs JB, Au R, Green RC, Farrer LA, Wolf PA, Seshadri S. Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study. Arch Neurol. 2006 Nov; 63(11):1551-5.View Related Profiles.

Beiser, Alexa
Farrer, Lindsay
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 17101823.

Seshadri S. Methodology for measuring cerebrovascular disease burden. Int Rev Psychiatry. 2006 Oct; 18(5):409-22. PMID: 17085360.

Elias MF, Sullivan LM, Elias PK, Vasan RS, D'Agostino RB, Seshadri S, Au R, Wolf PA, Benjamin EJ. Atrial fibrillation is associated with lower cognitive performance in the Framingham offspring men. J Stroke Cerebrovasc Dis. 2006 Sep-Oct; 15(5):214-22.View Related Profiles.

Benjamin, Emelia
Sullivan, Lisa
Wolf, Philip
D'Agostino, Ralph
Au, Rhoda
Seshadri, Sudha
Ramachandran, Vasan

PMID: 17904078.

Seshadri S. Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer's disease? J Alzheimers Dis. 2006 Aug; 9(4):393-8. PMID: 16917147.

McKee AC, Au R, Cabral HJ, Kowall NW, Seshadri S, Kubilus CA, Drake J, Wolf PA. Visual association pathology in preclinical Alzheimer disease. J Neuropathol Exp Neurol. 2006 Jun; 65(6):621-30.View Related Profiles.

McKee, Ann
Cabral, Howard
Kowall, Neil
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 16783172.

Au R, Massaro JM, Wolf PA, Young ME, Beiser A, Seshadri S, D'Agostino RB, DeCarli C. Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart Study. Arch Neurol. 2006 Feb; 63(2):246-50.View Related Profiles.

Beiser, Alexa
Massaro, Joseph
Young, Megan
Wolf, Philip
D'Agostino, Ralph
Au, Rhoda
Seshadri, Sudha

PMID: 16476813.

Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Au R, Kannel WB, Wolf PA. The lifetime risk of stroke: estimates from the Framingham Study. Stroke. 2006 Feb; 37(2):345-50.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Kelly-Hayes, Margaret
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 16397184.

Elias MF, Sullivan LM, D'Agostino RB, Elias PK, Jacques PF, Selhub J, Seshadri S, Au R, Beiser A, Wolf PA. Homocysteine and cognitive performance in the Framingham offspring study: age is important. Am J Epidemiol. 2005 Oct 1; 162(7):644-53.View Related Profiles.

Beiser, Alexa
Sullivan, Lisa
Wolf, Philip
D'Agostino, Ralph
Au, Rhoda
Seshadri, Sudha

PMID: 16107567.

Tan ZS, Seshadri S, Beiser A, Zhang Y, Felson D, Hannan MT, Au R, Wolf PA, Kiel DP. Bone mineral density and the risk of Alzheimer disease. Arch Neurol. 2005 Jan; 62(1):107-11.View Related Profiles.

Beiser, Alexa
Felson, David
Wolf, Philip
Au, Rhoda
Seshadri, Sudha
Zhang, Yuqing

PMID: 15642856.

Seshadri S, Wolf PA, Beiser A, Elias MF, Au R, Kase CS, D'Agostino RB, DeCarli C. Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study. Neurology. 2004 Nov 9; 63(9):1591-9.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Wolf, Philip
D'Agostino, Ralph
Seshadri, Sudha

PMID: 15534241.

Au R, Seshadri S, Wolf PA, Elias M, Elias P, Sullivan L, Beiser A, D'Agostino RB. New norms for a new generation: cognitive performance in the framingham offspring cohort. Exp Aging Res. 2004 Oct-Dec; 30(4):333-58.View Related Profiles.

Beiser, Alexa
Sullivan, Lisa
Wolf, Philip
D'Agostino, Ralph
Au, Rhoda
Seshadri, Sudha

PMID: 15371099.

Jeerakathil T, Wolf PA, Beiser A, Massaro J, Seshadri S, D'Agostino RB, DeCarli C. Stroke risk profile predicts white matter hyperintensity volume: the Framingham Study. Stroke. 2004 Aug; 35(8):1857-61.View Related Profiles.

Beiser, Alexa
Massaro, Joseph
Wolf, Philip
D'Agostino, Ralph
Seshadri, Sudha

PMID: 15218158.

Ivan CS, Seshadri S, Beiser A, Au R, Kase CS, Kelly-Hayes M, Wolf PA. Dementia after stroke: the Framingham Study. Stroke. 2004 Jun; 35(6):1264-8.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Kelly-Hayes, Margaret
Wolf, Philip
Au, Rhoda
Seshadri, Sudha

PMID: 15118167.

Elias MF, Sullivan LM, D'Agostino RB, Elias PK, Beiser A, Au R, Seshadri S, DeCarli C, Wolf PA. Framingham stroke risk profile and lowered cognitive performance. Stroke. 2004 Feb; 35(2):404-9.View Related Profiles.

Beiser, Alexa
Sullivan, Lisa
Wolf, Philip
D'Agostino, Ralph
Au, Rhoda
Seshadri, Sudha

PMID: 14726556.

Seshadri S, Beiser A, Ivan CS, Au R, Kase CS, Kelly-Hayes M, Wolf PA. Does preventing stroke prevent all kinds of dementia? Response. [letter]. Stroke. 2004; 35:2437. View Publication

Seshadri S. Nucleic acid amplification tests for tuberculous meningitis: a systematic review of diagnostic accuracy. Natl Med J India. 2003 Sep-Oct; 16(5):260-1. PMID: 14680282.

Tan ZS, Seshadri S, Beiser A, Wilson PW, Kiel DP, Tocco M, D'Agostino RB, Wolf PA. Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study. Arch Intern Med. 2003 May 12; 163(9):1053-7.View Related Profiles.

Beiser, Alexa
Wolf, Philip
D'Agostino, Ralph
Seshadri, Sudha

PMID: 12742802.

Seshadri S, Wolf PA. Homocysteine and the brain: vascular risk factor or neurotoxin? Lancet Neurol. 2003 Jan; 2(1):11.View Related Profiles.

Wolf, Philip
Seshadri, Sudha

PMID: 12849292.

Vasan RS, Beiser A, Seshadri S, Larson MG, Kannel WB, D'Agostino RB, Levy D. Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study. JAMA. 2002 Feb 27; 287(8):1003-10.View Related Profiles.

Beiser, Alexa
Larson, Martin
D'Agostino, Ralph
Seshadri, Sudha
Ramachandran, Vasan

PMID: 11866648.

Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002 Feb 14; 346(7):476-83.View Related Profiles.

Beiser, Alexa
Wolf, Philip
D'Agostino, Ralph
Seshadri, Sudha

PMID: 11844848.

Vasan RS, Massaro JM, Wilson PW, Seshadri S, Wolf PA, Levy D, D'Agostino RB. Antecedent blood pressure and risk of cardiovascular disease: the Framingham Heart Study . Circulation. 2002 Jan 1; 105(1):48-53.View Related Profiles.

Massaro, Joseph
Wolf, Philip
D'Agostino, Ralph
Seshadri, Sudha
Ramachandran, Vasan

PMID: 11772875.

Seshadri S, Wolf PA. Homocysteine and dementia – Reply. [letter]. N Engl J Med. 2002; 346:2008. View Publication

Zhang Y, Seshadri S, Ellison RC, Heeren T, Felson DT. Bone mineral density and verbal memory impairment: Third National Health and Nutrition Examination Survey. Am J Epidemiol. 2001 Nov 1; 154(9):795-802.View Related Profiles.

Felson, David
Ellison, Robert
Seshadri, Sudha
Heeren, Timothy
Zhang, Yuqing

PMID: 11682361.

Seshadri S, Wolf PA, Beiser A, Vasan RS, Wilson PW, Kase CS, Kelly-Hayes M, Kannel WB, D'Agostino RB. Elevated midlife blood pressure increases stroke risk in elderly persons: the Framingham Study. Arch Intern Med. 2001 Oct 22; 161(19):2343-50.View Related Profiles.

Beiser, Alexa
Kase, Carlos
Kelly-Hayes, Margaret
Wolf, Philip
D'Agostino, Ralph
Seshadri, Sudha
Ramachandran, Vasan

PMID: 11606150.

Seshadri S, Zornberg GL, Derby LE, Myers MW, Jick H, Drachman DA. Postmenopausal estrogen replacement therapy and the risk of Alzheimer disease. Arch Neurol. 2001 Mar; 58(3):435-40.View Related Profiles.

Jick, Hershel
Seshadri, Sudha

PMID: 11255447.

Tripathi M, Seshadri S, Padma MV, Jain S, Maheshwari MC, Behari M. Serum cobalamin levels in dementias. Neurology India. 2001; 49:284-6. View Publication

Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA. Dementia and statins- reply [letter]. Lancet. 2001; 357:880-881. View Publication

Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA. Statins and the risk of dementia. Lancet. 2000 Nov 11; 356(9242):1627-31.View Related Profiles.

Jick, Hershel
Seshadri, Sudha
Jick, Susan

PMID: 11089820.

Beiser A, D'Agostino RB, Seshadri S, Sullivan LM, Wolf PA. Computing estimates of incidence, including lifetime risk: Alzheimer's disease in the Framingham Study. The Practical Incidence Estimators (PIE) macro. Stat Med. 2000 Jun 15-30; 19(11-12):1495-522.View Related Profiles.

Beiser, Alexa
Sullivan, Lisa
Wolf, Philip
D'Agostino, Ralph
Seshadri, Sudha

PMID: 10844714.

Tandon R, Khanna S, Sharma MC, Seshadri S, Menon V. Subacute sclerosing panencephalitis presenting as optic neuritis. Indian J Ophthalmol. 1999 Dec; 47(4):250-2. PMID: 10892484.

Seshadri S, Wolf PA, Beiser A, Au R, McNulty K, White R, D'Agostino RB. Lifetime risk of dementia and Alzheimer's disease. The impact of mortality on risk estimates in the Framingham Study. Neurology. 1997 Dec; 49(6):1498-504.View Related Profiles.

Beiser, Alexa
Sullivan, Kimberly
Wolf, Philip
D'Agostino, Ralph
Au, Rhoda
Seshadri, Sudha

PMID: 9409336.

Seshadri S, Drachman DA, Lippa CF. Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know. Arch Neurol. 1995 Nov; 52(11):1074-9. PMID: 7487559.

Seshadri S, Jain S, Maheshwari MC. Neurological manifestations of AIDS. J Assoc Physicians India. 1994 Apr; 42(4):309-10, 315. PMID: 7860551.

Behari M, Singh KK, Seshadri S, Prasad K, Ahuja GK. Botulinum toxin A in blepharospasm and hemifacial spasm. J Assoc Physicians India. 1994 Mar; 42(3):205-8. PMID: 7860509.

Seshadri S, Narula J, Chopra P. Asymptomatic eosinophilic myocarditis: 2 + 2 = 4 or 5! Int J Cardiol. 1991 Jun; 31(3):348-9. PMID: 1879984.

Vasan RS, Seshadri S, Narula J. Atrial natriuretic peptide: an atavistic hormone? Int J Cardiol. 1989 Mar; 22(3):407-8.View Related Profiles.

Seshadri, Sudha
Ramachandran, Vasan

PMID: 2523362.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2001

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2001

Year	Publications
2001	2
2002	1
2004	1
2009	1
2010	1

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