Marc Lenburg | Profiles RNS

Marc Lenburg, PhD

Professor

Boston University School of Medicine

Dept of Medicine

Computational Biomedicine

PhD, University of California, San Francisco

Websites

Department of Medicine Faculty

ORCID : 0000-0002-5760-4708

Expertise in computational approaches to leverage genome-wide datasets (especially genome-wide gene-expression) for clinical and biological insight. Interests include developing and applying these tools for translational research.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

Professor
Boston University School of Medicine
Pathology & Laboratory Medicine

Member
Boston University
Bioinformatics Graduate Program

BU Sponsored Research
NIH RePORTER Sponsored Research

Molecular and Imaging biomarkers for early lung cancer detection in the setting of Indeterminate Pulmonary Nodules
09/23/2016 - 08/31/2021 (Multi-PI)
PI: Marc Lenburg, PhD
NIH/National Cancer Institute
5R01CA210360-02

The Boston University-UCLA Lung Cancer Biomarker Development Lab
09/20/2016 - 08/31/2021 (Co-PI)
PI: Avrum Spira, MD
NIH/National Cancer Institute
5U01CA214182-02

Study BET inhibitors in COPD
12/18/2017 - 12/17/2018 (PI)
AstraZeneca AB

Integrative Omics to Discover Molecular Determinants of COPD
06/01/2016 - 05/31/2018 (Multi-PI)
PI: Marc Lenburg, PhD
NIH/National Heart, Lung, and Blood Institute
4R01HL118542-04

Molecular biomarkers of airway and lung linking COPD and Lung Cancer
09/15/2011 - 07/31/2016 (Co-PI)
PI: Avrum Spira, MD
NIH/National Cancer Institute
5R01CA164783-04

Integrative Omics to Discover Molecular Determinants of COPD
08/15/2013 - 05/31/2016 (Multi-PI)
PI: Marc Lenburg, PhD
NIH/National Heart, Lung, and Blood Institute
5R01HL118542-03

Validation of a Genomic Biomarker of Responses to Environmental Tobacco Smoke
08/08/2011 - 06/30/2015 (Multi-PI)
PI: Marc Lenburg, PhD
NIH/National Institute of Environmental Health Sciences
5R01ES020425-02

Yr	Title	Project-Sub Proj	Pubs
2017	Molecular and Imaging Biomarkers for Early Lung Cancer Detection in the Setting of Indeterminate Pulmonary Nodules	5R01CA210360-02
2017	The Boston University-UCLA Lung Cancer Biomarker Development Lab	5U01CA214182-02
2016	Molecular and Imaging Biomarkers for Early Lung Cancer Detection in the Setting of Indeterminate Pulmonary Nodules	1R01CA210360-01
2016	The Boston University-UCLA Lung Cancer Biomarker Development Lab	1U01CA214182-01
2016	Integrative Omics to Discover Molecular Determinants of COPD	4R01HL118542-04	1
2015	The UCLA - Boston University Lung Cancer Biomarker Development Laboratory	3U01CA152751-05S2	12
2014	Integrative Omics to Discover Molecular Determinants of COPD	5R01HL118542-02	1
2014	Molecular biomarkers of airway and lung linking COPD and Lung Cancer	5R01CA164783-04	10
2014	The UCLA - Boston University Lung Cancer Biomarker Development Laboratory	5U01CA152751-05	12
2013	Integrative Omics to Discover Molecular Determinants of COPD	1R01HL118542-01	1

Showing 10 of 26 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Billatos E, Faiz A, Gesthalter YO, LeClerc A, Alekseyev Y, Zhang X, Liu G, Ten Hacken NHT, Heijink I, Timens W, Brandsma CA, Postma DS, van den Berge M, Spira A, Lenburg ME. The Impact of Acute Exposure to Cigarette Smoke on Airway Gene Expression. Physiol Genomics. 2018 06 22.View Related Profiles.

Spira, Avrum
Billatos, Ehab
Liu, Gang
Lenburg, Marc
Alekseyev, Yuriy

PMID: 29932825.

Billatos E, Vick JL, Lenburg ME, Spira AE. The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection. Clin Cancer Res. 2018 Jul 01; 24(13):2984-2992.View Related Profiles.

Spira, Avrum
Billatos, Ehab
Lenburg, Marc

PMID: 29463557.

Boudewijn IM, Faiz A, Steiling K, van der Wiel E, Telenga ED, Hoonhorst SJM, Ten Hacken NHT, Brandsma CA, Kerstjens HAM, Timens W, Heijink IH, Jonker MR, de Bruin HG, Sebastiaan Vroegop J, Pasma HR, Boersma WG, Wielders P, van den Elshout F, Mansour K, Spira A, Lenburg ME, Guryev V, Postma DS, van den Berge M. Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression. Respir Res. 2017 12 21; 18(1):213.View Related Profiles.

Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 29268739.

Ong J, Timens W, Rajendran V, Algra A, Spira A, Lenburg ME, Campbell JD, van den Berge M, Postma DS, van den Berg A, Kluiver J, Brandsma CA. Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts. PLoS One. 2017; 12(9):e0183815.View Related Profiles.

Spira, Avrum
Lenburg, Marc

PMID: 28910321.

Pavel AB, Campbell JD, Liu G, Elashoff D, Dubinett S, Smith K, Whitney D, Lenburg ME, Spira A. Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection. Cancer Prev Res (Phila). 2017 Nov; 10(11):651-659.View Related Profiles.

Spira, Avrum
Liu, Gang
Lenburg, Marc

PMID: 28877936.

Suzuki M, Sze MA, Campbell JD, Brothers JF, Lenburg ME, McDonough JE, Elliott WM, Cooper JD, Spira A, Hogg JC. The cellular and molecular determinants of emphysematous destruction in COPD. Sci Rep. 2017 Aug 25; 7(1):9562.View Related Profiles.

Spira, Avrum
Lenburg, Marc

PMID: 28842670.

Shared Gene Expression Alterations in Nasal and Bronchial Epithelium for Lung Cancer Detection. J Natl Cancer Inst. 2017 Jul 01; 109(7). PMID: 28376173; DOI: 10.1093/jnci/djw327;.

Beane J, Mazzilli SA, Tassinari AM, Liu G, Zhang X, Liu H, Buncio AD, Dhillon SS, Platero SJ, Lenburg ME, Reid ME, Lam S, Spira AE. Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression. Clin Cancer Res. 2017 Sep 01; 23(17):5091-5100.View Related Profiles.

Spira, Avrum
Liu, Gang
Liu, Hanqiao
Beane-Ebel, Jennifer
Lenburg, Marc
Mazzilli, Sarah

PMID: 28533227.

Hu Z, Mao JH, Curtis C, Huang G, Gu S, Heiser L, Lenburg ME, Korkola JE, Bayani N, Samarajiwa S, Seoane JA, Dane MA, Esch A, Feiler HS, Wang NJ, Hardwicke MA, Laquerre S, Jackson J, Wood KW, Weber B, Spellman PT, Aparicio S, Wooster R, Caldas C, Gray JW. Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer. Breast Cancer Res. 2017 02 09; 19(1):17. PMID: 28183333; DOI: 10.1186/s13058-017-0809-6;.

Vasilescu DM, Phillion AB, Tanabe N, Kinose D, Paige DF, Kantrowitz JJ, Liu G, Liu H, Fishbane N, Verleden SE, Vanaudenaerde BM, Lenburg M, Stevenson CS, Spira A, Cooper JD, Hackett TL, Hogg JC. Nondestructive cryomicro-CT imaging enables structural and molecular analysis of human lung tissue. J Appl Physiol (1985). 2017 Jan 01; 122(1):161-169.View Related Profiles.

Spira, Avrum
Liu, Gang
Lenburg, Marc

PMID: 27856720; DOI: 10.1152/japplphysiol.00838.2016;.

Showing 10 of 85 results. Show More

Kusko RL, Brothers JF, Tedrow J, Pandit K, Huleihel L, Perdomo C, Liu G, Juan-Guardela B, Kass D, Zhang S, Lenburg M, Martinez F, Quackenbush J, Sciurba F, Limper A, Geraci M, Yang I, Schwartz DA, Beane J, Spira A, Kaminski N. Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016 Oct 15; 194(8):948-960.View Related Profiles.

Spira, Avrum
Liu, Gang
Lenburg, Marc
Kusko, Rebecca

PMID: 27104832.

Moses E, Wang T, Corbett S, Jackson GR, Drizik E, Perdomo C, Perdomo C, Kleerup E, Brooks D, O'Connor G, Dubinett S, Hayden P, Lenburg ME, Spira A. Molecular Impact of Electronic Cigarette Aerosol Exposure in Human Bronchial Epithelium. Toxicol Sci. 2017 Jan; 155(1):248-257.View Related Profiles.

Spira, Avrum
Brooks, Daniel
Moses, Elizabeth
O'Connor, George
Lenburg, Marc

PMID: 27701119; DOI: 10.1093/toxsci/kfw198;.

Lam S, Mandrekar SJ, Gesthalter Y, Allen Ziegler KL, Seisler DK, Midthun DE, Mao JT, Aubry MC, McWilliams A, Sin DD, Shaipanich T, Liu G, Johnson E, Bild A, Lenburg ME, Ionescu DN, Mayo J, Yi JE, Tazelaar H, Harmsen WS, Smith J, Spira AE, Beane J, Limburg PJ, Szabo E. A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia. Cancer Prev Res (Phila). 2016 Dec; 9(12):906-914.View Related Profiles.

Spira, Avrum
Liu, Gang
Lenburg, Marc

PMID: 27658890.

Hu Z, Mao JH, Curtis C, Huang G, Gu S, Heiser L, Lenburg ME, Korkola JE, Bayani N, Samarajiwa S, Seoane JA, A Dane M, Esch A, Feiler HS, Wang NJ, Hardwicke MA, Laquerre S, Jackson J, W Wood K, Weber B, Spellman PT, Aparicio S, Wooster R, Caldas C, Gray JW. Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer. Breast Cancer Res. 2016 Jul 01; 18(1):70. PMID: 27368372; PMCID: PMC4930593; DOI: 10.1186/s13058-016-0728-y;.

Vachani A, Whitney DH, Parsons EC, Lenburg M, Ferguson JS, Silvestri GA, Spira A. Clinical Utility of a Bronchial Genomic Classifier in Patients With Suspected Lung Cancer. Chest. 2016 Jul; 150(1):210-8.View Related Profiles.

Spira, Avrum
Lenburg, Marc

PMID: 26896702; DOI: 10.1016/j.chest.2016.02.636;.

Wang TW, Vermeulen RC, Hu W, Liu G, Xiao X, Alekseyev Y, Xu J, Reiss B, Steiling K, Downward GS, Silverman DT, Wei F, Wu G, Li J, Lenburg ME, Rothman N, Spira A, Lan Q. Gene-expression profiling of buccal epithelium among non-smoking women exposed to household air pollution from smoky coal. Carcinogenesis. 2015 Dec; 36(12):1494-501.View Related Profiles.

Spira, Avrum
Liu, Gang
Steiling, Katrina
Lenburg, Marc
Alekseyev, Yuriy

PMID: 26468118; PMCID: PMC4675833; DOI: 10.1093/carcin/bgv150;.

Sze MA, Dimitriu PA, Suzuki M, McDonough JE, Campbell JD, Brothers JF, Erb-Downward JR, Huffnagle GB, Hayashi S, Elliott WM, Cooper J, Sin DD, Lenburg ME, Spira A, Mohn WW, Hogg JC. Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2015 Aug 15; 192(4):438-45.View Related Profiles.

Spira, Avrum
Campbell, Joshua
Lenburg, Marc

PMID: 25945594; PMCID: PMC4595667; DOI: 10.1164/rccm.201502-0223OC;.

Silvestri GA, Vachani A, Whitney D, Elashoff M, Porta Smith K, Ferguson JS, Parsons E, Mitra N, Brody J, Lenburg ME, Spira A. A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer. N Engl J Med. 2015 Jul 16; 373(3):243-51.View Related Profiles.

Spira, Avrum
Brody, Jerome
Lenburg, Marc

PMID: 25981554; DOI: 10.1056/NEJMoa1504601;.

Whitney DH, Elashoff MR, Porta-Smith K, Gower AC, Vachani A, Ferguson JS, Silvestri GA, Brody JS, Lenburg ME, Spira A. Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy. BMC Med Genomics. 2015; 8:18.View Related Profiles.

Gower, Adam
Spira, Avrum
Brody, Jerome
Lenburg, Marc

PMID: 25944280; PMCID: PMC4434538; DOI: 10.1186/s12920-015-0091-3;.

Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015 Aug; 14(4):644-58.View Related Profiles.

Gower, Adam
Lenburg, Marc

PMID: 25754370; PMCID: PMC4531078; DOI: 10.1111/acel.12344;.

Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG. Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015 Apr 1; 191(7):758-66.View Related Profiles.

Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 25611785; PMCID: PMC4407484; DOI: 10.1164/rccm.201408-1458OC;.

Campbell JD, Liu G, Luo L, Xiao J, Gerrein J, Juan-Guardela B, Tedrow J, Alekseyev YO, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Schwartz DA, Kaminski N, Johnson WE, Monti S, Spira A, Beane J, Lenburg ME. Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data. RNA. 2015 Feb; 21(2):164-71.View Related Profiles.

Spira, Avrum
Liu, Gang
Beane-Ebel, Jennifer
Campbell, Joshua
Luo, Lingqi
Lenburg, Marc
Monti, Stefano
Johnson, William
Alekseyev, Yuriy

PMID: 25519487; PMCID: PMC4338344; DOI: 10.1261/rna.046060.114;.

Lamontagne M, Timens W, Hao K, Bossé Y, Laviolette M, Steiling K, Campbell JD, Couture C, Conti M, Sherwood K, Hogg JC, Brandsma CA, van den Berge M, Sandford A, Lam S, Lenburg ME, Spira A, Paré PD, Nickle D, Sin DD, Postma DS. Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction. Thorax. 2014 Nov; 69(11):997-1004.View Related Profiles.

Spira, Avrum
Campbell, Joshua
Steiling, Katrina
Lenburg, Marc

PMID: 25182044; DOI: 10.1136/thoraxjnl-2014-205630;.

Vucic EA, Chari R, Thu KL, Wilson IM, Cotton AM, Kennett JY, Zhang M, Lonergan KM, Steiling K, Brown CJ, McWilliams A, Ohtani K, Lenburg ME, Sin DD, Spira A, Macaulay CE, Lam S, Lam WL. DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways. Am J Respir Cell Mol Biol. 2014 May; 50(5):912-22.View Related Profiles.

Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 24298892; PMCID: PMC4068945; DOI: 10.1165/rcmb.2013-0304OC;.

Ooi AT, Gower AC, Zhang KX, Vick JL, Hong L, Nagao B, Wallace WD, Elashoff DA, Walser TC, Dubinett SM, Pellegrini M, Lenburg ME, Spira A, Gomperts BN. Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis. Cancer Prev Res (Phila). 2014 May; 7(5):487-95.View Related Profiles.

Gower, Adam
Spira, Avrum
Lenburg, Marc

PMID: 24618292; PMCID: PMC4059064; DOI: 10.1158/1940-6207.CAPR-13-0372;.

Wolf DM, Lenburg ME, Yau C, Boudreau A, van 't Veer LJ. Gene co-expression modules as clinically relevant hallmarks of breast cancer diversity. PLoS One. 2014; 9(2):e88309. PMID: 24516633; PMCID: PMC3917875; DOI: 10.1371/journal.pone.0088309;.

Krysan K, Kusko R, Grogan T, O'Hearn J, Reckamp KL, Walser TC, Garon EB, Lenburg ME, Sharma S, Spira AE, Elashoff D, Dubinett SM. PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC. Mol Cancer Res. 2014 May; 12(5):765-74.View Related Profiles.

Spira, Avrum
Lenburg, Marc
Kusko, Rebecca

PMID: 24469837; PMCID: PMC4020971; DOI: 10.1158/1541-7786.MCR-13-0377;.

Christenson SA, Brandsma CA, Campbell JD, Knight DA, Pechkovsky DV, Hogg JC, Timens W, Postma DS, Lenburg M, Spira A. miR-638 regulates gene expression networks associated with emphysematous lung destruction. Genome Med. 2013; 5(12):114.View Related Profiles.

Spira, Avrum
Campbell, Joshua
Lenburg, Marc

PMID: 24380442; DOI: 10.1186/gm519;.

Steiling K, Lenburg ME, Spira A. Personalized management of chronic obstructive pulmonary disease via transcriptomic profiling of the airway and lung. Ann Am Thorac Soc. 2013 Dec; 10 Suppl:S190-6.View Related Profiles.

Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 24313772; PMCID: PMC3960986; DOI: 10.1513/AnnalsATS.201306-190AW;.

Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, Gomperts BN, Dubinett SM, Hayden P, Belinsky SA, Lenburg ME, Spira A. MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):18946-51.View Related Profiles.

Gower, Adam
Spira, Avrum
O'Hara, Carl
Garrison, Carly
Schembri, Frank
Campbell, Joshua
Lenburg, Marc

PMID: 24158479; PMCID: PMC3839685; DOI: 10.1073/pnas.1220319110;.

van den Berge M, Steiling K, Timens W, Hiemstra PS, Sterk PJ, Heijink IH, Liu G, Alekseyev YO, Lenburg ME, Spira A, Postma DS. Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity. Thorax. 2014 Jan; 69(1):14-23.View Related Profiles.

Spira, Avrum
Liu, Gang
Steiling, Katrina
Lenburg, Marc
Alekseyev, Yuriy

PMID: 23925644; PMCID: PMC3888587; DOI: 10.1136/thoraxjnl-2012-202878;.

Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O'Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med. 2013 May 1; 187(9):933-42.View Related Profiles.

Spira, Avrum
Dumont, Charles
Liu, Gang
O'Connor, George
Duclos, Grant
Campbell, Joshua
Steiling, Katrina
Lenburg, Marc
Sebastiani, Paola
Alekseyev, Yuriy

PMID: 23471465; PMCID: PMC3707363; DOI: 10.1164/rccm.201208-1449OC;.

Zhang X, Lenburg ME, Spira A. Comparison of nasal epithelial smoking-induced gene expression on Affymetrix Exon 1.0 and Gene 1.0 ST arrays. ScientificWorldJournal. 2013; 2013:951416.View Related Profiles.

Spira, Avrum
Lenburg, Marc
Zhang, Xiaoling

PMID: 23476154; PMCID: PMC3588192; DOI: 10.1155/2013/951416;.

Beane J, Cheng L, Soldi R, Zhang X, Liu G, Anderlind C, Lenburg ME, Spira A, Bild AH. SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue. Cancer Res. 2012 Nov 15; 72(22):5702-11.View Related Profiles.

Spira, Avrum
Liu, Gang
Beane-Ebel, Jennifer
Lenburg, Marc

PMID: 22986747; DOI: 10.1158/0008-5472.CAN-12-1043;.

Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma CA, Suzuki M, Gosselink JV, Liu G, Alekseyev YO, Xiao J, Zhang X, Hayashi S, Cooper JD, Timens W, Postma DS, Knight DA, Lenburg ME, Hogg JC, Spira A. A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. Genome Med. 2012; 4(8):67.View Related Profiles.

Spira, Avrum
Liu, Gang
Campbell, Joshua
Lenburg, Marc
Alekseyev, Yuriy

PMID: 22937864; DOI: 10.1186/gm368;.

Piccolo SR, Sun Y, Campbell JD, Lenburg ME, Bild AH, Johnson WE. A single-sample microarray normalization method to facilitate personalized-medicine workflows. Genomics. 2012 Dec; 100(6):337-44.View Related Profiles.

Campbell, Joshua
Lenburg, Marc
Piccolo, Stephen
Johnson, William

PMID: 22959562; PMCID: PMC3508193; DOI: 10.1016/j.ygeno.2012.08.003;.

Lee SY, Meier R, Furuta S, Lenburg ME, Kenny PA, Xu R, Bissell MJ. FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice. J Clin Invest. 2012 Sep 4; 122(9):3211-20. PMID: 22886303; PMCID: PMC3428077; DOI: 10.1172/JCI60498;.

Horiuchi D, Kusdra L, Huskey NE, Chandriani S, Lenburg ME, Gonzalez-Angulo AM, Creasman KJ, Bazarov AV, Smyth JW, Davis SE, Yaswen P, Mills GB, Esserman LJ, Goga A. MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. J Exp Med. 2012 Apr 9; 209(4):679-96. PMID: 22430491; PMCID: PMC3328367; DOI: 10.1084/jem.20111512;.

Esserman LJ, Berry DA, Cheang MC, Yau C, Perou CM, Carey L, DeMichele A, Gray JW, Conway-Dorsey K, Lenburg ME, Buxton MB, Davis SE, van't Veer LJ, Hudis C, Chin K, Wolf D, Krontiras H, Montgomery L, Tripathy D, Lehman C, Liu MC, Olopade OI, Rugo HS, Carpenter JT, Livasy C, Dressler L, Chhieng D, Singh B, Mies C, Rabban J, Chen YY, Giri D, Au A, Hylton N. Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657). Breast Cancer Res Treat. 2012 Apr; 132(3):1049-62. PMID: 22198468; PMCID: PMC3332388; DOI: 10.1007/s10549-011-1895-2;.

Gower AC, Spira A, Lenburg ME. Discovering biological connections between experimental conditions based on common patterns of differential gene expression. BMC Bioinformatics. 2011; 12:381.View Related Profiles.

Gower, Adam
Spira, Avrum
Lenburg, Marc

PMID: 21951600; PMCID: PMC3203354; DOI: 10.1186/1471-2105-12-381;.

Beane J, Vick J, Schembri F, Anderlind C, Gower A, Campbell J, Luo L, Zhang XH, Xiao J, Alekseyev YO, Wang S, Levy S, Massion PP, Lenburg M, Spira A. Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq. Cancer Prev Res (Phila). 2011 Jun; 4(6):803-17.View Related Profiles.

Gower, Adam
Spira, Avrum
Schembri, Frank
Beane-Ebel, Jennifer
Campbell, Joshua
Luo, Lingqi
Lenburg, Marc
Alekseyev, Yuriy

PMID: 21636547; PMCID: PMC3694393; DOI: 10.1158/1940-6207.CAPR-11-0212;.

Gower AC, Steiling K, Brothers JF, Lenburg ME, Spira A. Transcriptomic studies of the airway field of injury associated with smoking-related lung disease. Proc Am Thorac Soc. 2011 May; 8(2):173-9.View Related Profiles.

Gower, Adam
Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 21543797; PMCID: PMC3159071; DOI: 10.1513/pats.201011-066MS;.

Campbell JD, Spira A, Lenburg ME. Applying gene expression microarrays to pulmonary disease. Respirology. 2011 Apr; 16(3):407-18.View Related Profiles.

Spira, Avrum
Campbell, Joshua
Lenburg, Marc

PMID: 21299687; DOI: 10.1111/j.1440-1843.2011.01942.x;.

Boelens MC, Gustafson AM, Postma DS, Kok K, van der Vries G, van der Vlies P, Spira A, Lenburg ME, Geerlings M, Sietsma H, Timens W, van den Berg A, Groen HJ. A chronic obstructive pulmonary disease related signature in squamous cell lung cancer. Lung Cancer. 2011 May; 72(2):177-83.View Related Profiles.

Spira, Avrum
Lenburg, Marc

PMID: 20832896; DOI: 10.1016/j.lungcan.2010.08.014;.

Ooi AT, Mah V, Nickerson DW, Gilbert JL, Ha VL, Hegab AE, Horvath S, Alavi M, Maresh EL, Chia D, Gower AC, Lenburg ME, Spira A, Solis LM, Wistuba II, Walser TC, Wallace WD, Dubinett SM, Goodglick L, Gomperts BN. Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer. Cancer Res. 2010 Aug 15; 70(16):6639-48.View Related Profiles.

Gower, Adam
Spira, Avrum
Lenburg, Marc

PMID: 20710044; PMCID: PMC2924777; DOI: 10.1158/0008-5472.CAN-10-0455;.

Panchenko MP, Siddiquee Z, Dombkowski DM, Alekseyev YO, Lenburg ME, Walker JD, Macgillivray TE, Preffer FI, Stone JR. Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasia. Am J Pathol. 2010 Sep; 177(3):1562-72.View Related Profiles.

Lenburg, Marc
Alekseyev, Yuriy

PMID: 20696773; PMCID: PMC2928985; DOI: 10.2353/ajpath.2010.100327;.

Blick T, Hugo H, Widodo E, Waltham M, Pinto C, Mani SA, Weinberg RA, Neve RM, Lenburg ME, Thompson EW. Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia. 2010 Jun; 15(2):235-52. PMID: 20521089; DOI: 10.1007/s10911-010-9175-z;.

Gustafson AM, Soldi R, Anderlind C, Scholand MB, Qian J, Zhang X, Cooper K, Walker D, McWilliams A, Liu G, Szabo E, Brody J, Massion PP, Lenburg ME, Lam S, Bild AH, Spira A. Airway PI3K pathway activation is an early and reversible event in lung cancer development. Sci Transl Med. 2010 Apr 7; 2(26):26ra25.View Related Profiles.

Spira, Avrum
Anderlind, Christina
Liu, Gang
Brody, Jerome
Qian, Jun
Lenburg, Marc

PMID: 20375364; PMCID: PMC3694402; DOI: 10.1126/scitranslmed.3000251;.

Salisbury Palomares KT, Gerstenfeld LC, Wigner NA, Lenburg ME, Einhorn TA, Morgan EF. Transcriptional profiling and biochemical analysis of mechanically induced cartilaginous tissues in a rat model. Arthritis Rheum. 2010 Apr; 62(4):1108-18.View Related Profiles.

Gerstenfeld, Louis
Lenburg, Marc
Einhorn, Thomas

PMID: 20131271; PMCID: PMC2929815; DOI: 10.1002/art.27343;.

Hu Z, Huang G, Sadanandam A, Gu S, Lenburg ME, Pai M, Bayani N, Blakely EA, Gray JW, Mao JH. The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer. Breast Cancer Res. 2010; 12(2):R18. PMID: 20211017; PMCID: PMC2879562; DOI: 10.1186/bcr2487;.

Cartwright MJ, Schlauch K, Lenburg ME, Tchkonia T, Pirtskhalava T, Cartwright A, Thomou T, Kirkland JL. Aging, depot origin, and preadipocyte gene expression. J Gerontol A Biol Sci Med Sci. 2010 Mar; 65(3):242-51. PMID: 20106964; PMCID: PMC2904595; DOI: 10.1093/gerona/glp213;.

Papageorgis P, Lambert AW, Ozturk S, Gao F, Pan H, Manne U, Alekseyev YO, Thiagalingam A, Abdolmaleky HM, Lenburg M, Thiagalingam S. Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res. 2010 Feb 1; 70(3):968-78.View Related Profiles.

Lambert, Arthur
Lenburg, Marc
Thiagalingam, Sam
Alekseyev, Yuriy

PMID: 20086175; PMCID: PMC2946209; DOI: 10.1158/0008-5472.CAN-09-1872;.

Steiling K, Lenburg ME, Spira A. Airway gene expression in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec; 6(8):697-700.View Related Profiles.

Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 20008878; PMCID: PMC2797071; DOI: 10.1513/pats.200907-076DP;.

Zhang X, Sebastiani P, Liu G, Schembri F, Zhang X, Dumas YM, Langer EM, Alekseyev Y, O'Connor GT, Brooks DR, Lenburg ME, Spira A. Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium. Physiol Genomics. 2010 Mar 3; 41(1):1-8.View Related Profiles.

Spira, Avrum
Brooks, Daniel
Schembri, Frank
Liu, Gang
O'Connor, George
Lenburg, Marc
Sebastiani, Paola
Alekseyev, Yuriy
Dumas, Yves-Martine

PMID: 19952278; PMCID: PMC2841495; DOI: 10.1152/physiolgenomics.00167.2009;.

Steiling K, Kadar AY, Bergerat A, Flanigon J, Sridhar S, Shah V, Ahmad QR, Brody JS, Lenburg ME, Steffen M, Spira A. Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers. PLoS One. 2009; 4(4):e5043.View Related Profiles.

Bergerat, Agnes M
Spira, Avrum
Brody, Jerome
Steiling, Katrina
Lenburg, Marc
Steffen, Martin

PMID: 19357784; PMCID: PMC2664466; DOI: 10.1371/journal.pone.0005043;.

Zhou J, Huang W, Tao R, Ibaragi S, Lan F, Ido Y, Wu X, Alekseyev YO, Lenburg ME, Hu GF, Luo Z. Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells. Oncogene. 2009 May 7; 28(18):1993-2002.View Related Profiles.

Lenburg, Marc
Ido, Yasuo
Alekseyev, Yuriy
Luo, Zhijun

PMID: 19347029; PMCID: PMC2679420; DOI: 10.1038/onc.2009.63;.

Zhu J, Sanborn JZ, Benz S, Szeto C, Hsu F, Kuhn RM, Karolchik D, Archie J, Lenburg ME, Esserman LJ, Kent WJ, Haussler D, Wang T. The UCSC Cancer Genomics Browser. Nat Methods. 2009 Apr; 6(4):239-40. PMID: 19333237; DOI: 10.1038/nmeth0409-239;.

Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Zhang X, Bowers J, Vaziri C, Ott K, Sensinger K, Collins JJ, Brody JS, Getts R, Lenburg ME, Spira A. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2319-24.View Related Profiles.

Spira, Avrum
Vaziri, Cyrus
Schembri, Frank
Liu, Gang
Brody, Jerome
Lu, Jining
Lenburg, Marc

PMID: 19168627; PMCID: PMC2650144; DOI: 10.1073/pnas.0806383106;.

Beane J, Spira A, Lenburg ME. Clinical impact of high-throughput gene expression studies in lung cancer. J Thorac Oncol. 2009 Jan; 4(1):109-18.View Related Profiles.

Spira, Avrum
Beane-Ebel, Jennifer
Lenburg, Marc

PMID: 19096318; PMCID: PMC2731413; DOI: 10.1097/JTO.0b013e31819151f8;.

Liu P, Slater DM, Lenburg M, Nevis K, Cook JG, Vaziri C. Replication licensing promotes cyclin D1 expression and G1 progression in untransformed human cells. Cell Cycle. 2009 Jan 1; 8(1):125-36.View Related Profiles.

Vaziri, Cyrus
Lenburg, Marc

PMID: 19106611; PMCID: PMC3032797.

Merritt WM, Lin YG, Han LY, Kamat AA, Spannuth WA, Schmandt R, Urbauer D, Pennacchio LA, Cheng JF, Nick AM, Deavers MT, Mourad-Zeidan A, Wang H, Mueller P, Lenburg ME, Gray JW, Mok S, Birrer MJ, Lopez-Berestein G, Coleman RL, Bar-Eli M, Sood AK. Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med. 2008 Dec 18; 359(25):2641-50. PMID: 19092150; PMCID: PMC2710981; DOI: 10.1056/NEJMoa0803785;.

Zeskind JE, Lenburg ME, Spira A. Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management. Proc Am Thorac Soc. 2008 Dec 1; 5(8):834-41.View Related Profiles.

Spira, Avrum
Lenburg, Marc

PMID: 19017738; PMCID: PMC2645236; DOI: 10.1513/pats.200807-074TH;.

Sridhar S, Schembri F, Zeskind J, Shah V, Gustafson AM, Steiling K, Liu G, Dumas YM, Zhang X, Brody JS, Lenburg ME, Spira A. Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium. BMC Genomics. 2008; 9:259.View Related Profiles.

Spira, Avrum
Schembri, Frank
Liu, Gang
Brody, Jerome
Steiling, Katrina
Lenburg, Marc
Dumas, Yves-Martine

PMID: 18513428; PMCID: PMC2435556; DOI: 10.1186/1471-2164-9-259;.

Blick T, Widodo E, Hugo H, Waltham M, Lenburg ME, Neve RM, Thompson EW. Epithelial mesenchymal transition traits in human breast cancer cell lines. Clin Exp Metastasis. 2008; 25(6):629-42. PMID: 18461285; DOI: 10.1007/s10585-008-9170-6;.

Tripathi A, King C, de la Morenas A, Perry VK, Burke B, Antoine GA, Hirsch EF, Kavanah M, Mendez J, Stone M, Gerry NP, Lenburg ME, Rosenberg CL. Gene expression abnormalities in histologically normal breast epithelium of breast cancer patients. Int J Cancer. 2008 Apr 1; 122(7):1557-66.View Related Profiles.

Antoine, Gregory
Mendez, Jane
Lenburg, Marc
Kavanah, Maureen

PMID: 18058819.

Beane J, Sebastiani P, Whitfield TH, Steiling K, Dumas YM, Lenburg ME, Spira A. A prediction model for lung cancer diagnosis that integrates genomic and clinical features. Cancer Prev Res (Phila). 2008 Jun; 1(1):56-64.View Related Profiles.

Spira, Avrum
Beane-Ebel, Jennifer
Steiling, Katrina
Lenburg, Marc
Sebastiani, Paola
Dumas, Yves-Martine

PMID: 19138936; DOI: 10.1158/1940-6207.CAPR-08-0011;.

Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI. Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. Gene Expr Patterns. 2008 Jan; 8(2):124-39.View Related Profiles.

Spira, Avrum
Beane-Ebel, Jennifer
Lu, Jining
Lenburg, Marc
Ramirez, Maria

PMID: 18023262; PMCID: PMC2440337.

Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, Gilman S, Dumas YM, Calner P, Sebastiani P, Sridhar S, Beamis J, Lamb C, Anderson T, Gerry N, Keane J, Lenburg ME, Brody JS. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nat Med. 2007 Mar; 13(3):361-6.View Related Profiles.

Spira, Avrum
Schembri, Frank
Liu, Gang
Beane-Ebel, Jennifer
Brody, Jerome
Steiling, Katrina
Lenburg, Marc
Sebastiani, Paola
Dumas, Yves-Martine

PMID: 17334370.

Herbert A, Lenburg ME, Ulrich D, Gerry NP, Schlauch K, Christman MF. Open-access database of candidate associations from a genome-wide SNP scan of the Framingham Heart Study. Nat Genet. 2007 Feb; 39(2):135-6.View Related Profiles.

Herbert, Alan
Lenburg, Marc

PMID: 17262019.

Zhang X, Liu G, Lenburg ME, Spira A. Comparison of smoking-induced gene expression on Affymetrix Exon and 3'-based expression arrays. Genome Inform. 2007; 18:247-57.View Related Profiles.

Spira, Avrum
Liu, Gang
Lenburg, Marc
Zhang, Xiaoling

PMID: 18546492.

Beane J, Sebastiani P, Liu G, Brody JS, Lenburg ME, Spira A. Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression. Genome Biol. 2007; 8(9):R201.View Related Profiles.

Spira, Avrum
Liu, Gang
Beane-Ebel, Jennifer
Brody, Jerome
Lenburg, Marc
Sebastiani, Paola

PMID: 17894889; PMCID: PMC2375039.

Lenburg ME, Sinha A, Faller DV, Denis GV. Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis. J Biol Chem. 2007 Feb 16; 282(7):4803-11.View Related Profiles.

Faller, Douglas
Denis, Gerald
Lenburg, Marc

PMID: 17166848; PMCID: PMC2819333.

Tchkonia T, Lenburg M, Thomou T, Giorgadze N, Frampton G, Pirtskhalava T, Cartwright A, Cartwright M, Flanagan J, Karagiannides I, Gerry N, Forse RA, Tchoukalova Y, Jensen MD, Pothoulakis C, Kirkland JL. Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E298-307. PMID: 16985259.

Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, Wichmann HE, Meitinger T, Hunter D, Hu FB, Colditz G, Hinney A, Hebebrand J, Koberwitz K, Zhu X, Cooper R, Ardlie K, Lyon H, Hirschhorn JN, Laird NM, Lenburg ME, Lange C, Christman MF. A common genetic variant is associated with adult and childhood obesity. Science. 2006 Apr 14; 312(5771):279-83.View Related Profiles.

Herbert, Alan
Lenburg, Marc

PMID: 16614226.

Kanefsky J, Lenburg M, Hai CM. Cholinergic receptor and cyclic stretch-mediated inflammatory gene expression in intact ASM. Am J Respir Cell Mol Biol. 2006 Apr; 34(4):417-25. PMID: 16339998; PMCID: PMC2644203.

Klings ES, Safaya S, Adewoye AH, Odhiambo A, Frampton G, Lenburg M, Gerry N, Sebastiani P, Steinberg MH, Farber HW. Differential gene expression in pulmonary artery endothelial cells exposed to sickle cell plasma. Physiol Genomics. 2005 May 11; 21(3):293-8.View Related Profiles.

Klings, Elizabeth
Farber, Harrison
Lenburg, Marc
Steinberg, Martin
Sebastiani, Paola

PMID: 15741505.

King C, Guo N, Frampton GM, Gerry NP, Lenburg ME, Rosenberg CL. Reliability and reproducibility of gene expression measurements using amplified RNA from laser-microdissected primary breast tissue with oligonucleotide arrays. J Mol Diagn. 2005 Feb; 7(1):57-64. PMID: 15681475; PMCID: PMC1867505.

Carson JP, Zhang N, Frampton GM, Gerry NP, Lenburg ME, Christman MF. Pharmacogenomic identification of targets for adjuvant therapy with the topoisomerase poison camptothecin. Cancer Res. 2004 Mar 15; 64(6):2096-104. PMID: 15026349.

Lenburg ME, Liou LS, Gerry NP, Frampton GM, Cohen HT, Christman MF. Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data. BMC Cancer. 2003 Nov 27; 3:31.View Related Profiles.

Cohen, Herbert
Lenburg, Marc

PMID: 14641932; PMCID: PMC317310.

Lenburg ME, O'Shea EK. Genetic evidence for a morphogenetic function of the Saccharomyces cerevisiae Pho85 cyclin-dependent kinase. Genetics. 2001 Jan; 157(1):39-51. PMID: 11139490; PMCID: PMC1283135.

Lenburg ME, O'Shea EK. Signaling phosphate starvation. Trends Biochem Sci. 1996 Oct; 21(10):383-7. PMID: 8918192.

Anderson SJ, Lenburg M, Landau NR, Garcia JV. The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef. J Virol. 1994 May; 68(5):3092-101. PMID: 8151774; PMCID: PMC236799.

Aiken C, Konner J, Landau NR, Lenburg ME, Trono D. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell. 1994 Mar 11; 76(5):853-64. PMID: 8124721.

Lenburg ME, Landau NR. Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4. J Virol. 1993 Dec; 67(12):7238-45. PMID: 8230446; PMCID: PMC238186.

Snyder RW, Lenburg ME, Seebaum AT, Grabel LB. Disruption of the cytoskeleton-extracellular matrix linkage promotes the accumulation of plasminogen activators in F9 derived parietal endoderm. Differentiation. 1992 Aug; 50(3):153-62. PMID: 1330791.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 85 publications over 21 distinct years, with a maximum of 9 publications in 2010

Bar chart showing 85 publications over 21 distinct years, with a maximum of 9 publications in 2010

Year	Publications
1992	1
1993	1
1994	2
1996	1
2001	1
2003	1
2004	1
2005	3
2006	3
2007	5
2008	6
2009	8
2010	9
2011	5
2012	5
2013	6
2014	6
2015	6
2016	6
2017	7
2018	2

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