Marc Lenburg | Profiles RNS

Marc Lenburg, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Computational Biomedicine

PhD, University of California San Francisco
BA, Wesleyan University

Pronouns: he/him/his

Websites

	Pathology & Laboratory Medicine Faculty
	Computational Biomedicine Faculty
	Spira-Lenburg Lab
	LinkedIn
	ResearchGate

ORCID : 0000-0002-5760-4708

Expertise in computational approaches to leverage genome-wide datasets (especially genome-wide gene-expression) for clinical and biological insight. Interests include developing and applying these tools for translational research.

Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Pulmonary Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Member
Boston University
Genome Science Institute

Member
Boston University
Bioinformatics Graduate Program

Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Integrating imaging and biopsy-derived molecular markers for the pre-surgical detection of indolent and aggressive early stage lung adenocarcinoma
07/10/2023 - 06/30/2028 (PI)
NIH/National Cancer Institute
5R01CA275015-03

The Boston University - UCLA Lung Cancer Biomarker Characterization Center
09/01/2022 - 07/31/2027 (Multi-PI)
PI: Marc Lenburg, PhD
NIH/National Cancer Institute
5U2CCA271898-04

Sequencing of nasal RNA from individuals at high risk for lung cancer
01/01/2023 - 12/31/2026 (PI)
Inova Health Care Services

RNA sequencing and data processing of nasal epithelium samples from never-smoking women in Guatemala
09/13/2025 - 09/12/2026 (PI)
NIH/National Cancer Institute

EXCAMP – effect of military exposures on airway gene expression and molecular modifiers of lung cancer among military personnel
10/15/2025 - 06/30/2026 (Subcontract PI)
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. USU Federal Med Sch

The Boston University Clinical and Transitional Science Institute
04/15/2020 - 03/31/2026 (Key Person)
PI: Megan H. Bair-Merritt, MD, MSCE
NIH/National Center for Advancing Translational Sciences
5UL1TR001430-09

EXCAMP -- effect of military exposures on airway gene expression and molecular modifiers of lung cancer among military personnel
07/01/2024 - 01/31/2026 (Subcontract PI)
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. USU Federal Med Sch

mRNA expression sequencing analysis of nasal swabs from workers exposed to electronic waste processing in Accra, Ghana
07/15/2025 - 09/20/2025 (Subcontract PI)
Westat, Inc. NIH NCI
75N91022D00006

Data sample and extraction, sequencing, and QC on samples from the GWAS replication lung cancer study
09/01/2024 - 08/31/2025 (PI)
NIH/National Cancer Institute

The American Lung Association (ALA) Lung Health Cohort
06/15/2019 - 06/30/2025 (Subcontract PI)
Northwestern University NIH NHLBI
5U01HL146408-06

Showing 10 of 24 results. Show All Results

Title

Yr	Title	Project-Sub Proj
2025	Integrating imaging and biopsy-derived molecular markers for the pre-surgical detection of indolent and aggressive early stage lung adenocarcinoma	5R01CA275015-03
2025	Admin Core	5U2CCA271898-04-6879
2025	The Boston University - UCLA Lung Cancer Biomarker Characterization Center	5U2CCA271898-04
2024	Integrating imaging and biopsy-derived molecular markers for the pre-surgical detection of indolent and aggressive early stage lung adenocarcinoma	5R01CA275015-02
2024	Admin Core	5U2CCA271898-03-6879
2024	The Boston University - UCLA Lung Cancer Biomarker Characterization Center	5U2CCA271898-03
2023	Integrating imaging and biopsy-derived molecular markers for the pre-surgical detection of indolent and aggressive early stage lung adenocarcinoma	1R01CA275015-01A1
2023	Admin Core	5U2CCA271898-02-6879
2023	The Boston University - UCLA Lung Cancer Biomarker Characterization Center	5U2CCA271898-02
2022	Admin Core	1U2CCA271898-01-5084

Showing 10 of 49 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Anderson KE, Tran LM, Krysan K, Kefella Y, Yu L, Fishbein GA, Rodriguez EF, Shabihkhani M, Stefanko DP, Green E, Liu G, Liu H, Zhang S, Kane E, Mehrad M, Spira AE, Dubinett SM, Burks EJ, Mazzilli SA, Lenburg ME, Beane JE. Archetype analysis of lung adenocarcinoma premalignancy links heterogeneity in premalignant lesions to diverging features of invasive disease. Mol Cancer Res. 2026 May 06.View Related Profiles.

Spira, Avrum
Burks, Eric
Kane, Erin
Lenburg, Marc
Mazzilli, Sarah

PMID: 42089783; DOI: 10.1158/1541-7786.MCR-25-1093;

Souery W, Wong J, Diaz AA, Xu K, Xiao X, Liu H, Liu G, Gower AC, Alekseyev YO, Billatos E, Lenburg ME. Validation of bronchial airway gene expression associated with bronchiectasis in nasal epithelium. ERJ Open Res. 2026 May; 12(3).View Related Profiles.

Gower, Adam
Billatos, Ehab
Lenburg, Marc
Souery, Whitney
Alekseyev, Yuriy

PMID: 42094231; PMCID: PMC13139922; DOI: 10.1183/23120541.00814-2025;

Ning B, Chiu DJ, Pfefferkorn RM, Cullinane E, Kefella Y, Kane E, Reyes-Ortiz V, Liu G, Zhang X, Liu H, Sultan L, Green E, Constant M, Spira AE, Campbell JD, Reid ME, Varelas X, Burks EJ, Lenburg ME, Mazzilli SA, Beane JE. Upregulation of an Epithelial miRNA Is Associated with Immune Evasion in Progressive Bronchial Premalignant Lesions. Cancer Immunol Res. 2026 Apr 02; 14(4):689-707.View Related Profiles.

Spira, Avrum
Chiu, Darren
Burks, Eric
Kane, Erin
Lenburg, Marc
Pfefferkorn, Roxana
Mazzilli, Sarah
Varelas, Xaralabos

PMID: 41670462; PMCID: PMC12969512; DOI: 10.1158/2326-6066.CIR-25-0431;

Steiner D, Sultan L, Sullivan T, Liu H, Xiao X, LeClerc A, Melvin S, Alekseyev YO, Liu G, Mazzilli SA, Zhang J, Suzuki K, Rieger-Christ K, Burks EJ, Beane J, Lenburg ME. Vascular invasion-associated gene expression is detectable in pre-surgical biopsies of stage I lung adenocarcinoma. Nat Commun. 2026 Mar 24; 17(1).View Related Profiles.

Steiner, Dylan
Burks, Eric
Lenburg, Marc
Mazzilli, Sarah
Alekseyev, Yuriy

PMID: 41876493; PMCID: PMC13013712; DOI: 10.1038/s41467-026-70600-2;

Okajima Y, Lenburg ME, Diaz AA. When asthmatic distal airways lose their identity: a new mechanism of mucus plugs pathogenesis. Am J Respir Crit Care Med. 2026 Feb 01; 212(2):197-198. PMID: 41738085; PMCID: PMC13003398; DOI: 10.1093/ajrccm/aamaf100;

Souery WN, Billatos E, Elalami R, San José Estépar R, Cho MH, Diaz AA, Lenburg ME. Mucus plugs-associated gene expression identifies pathophysiology shared with chronic bronchitis. Am J Respir Crit Care Med. 2026 Feb 01; 212(2):253-267.View Related Profiles.

Billatos, Ehab
Lenburg, Marc
Souery, Whitney

PMID: 41072469; PMCID: PMC12560677; DOI: 10.1164/rccm.202501-0262OC;

Anderson KE, Tran LM, Krysan K, Kefella Y, Yu L, Fishbein GA, Rodriguez E, Shabihkhani M, Stefanko DP, Green E, Liu G, Liu H, Zhang S, Kane E, Mehrad M, Spira AE, Dubinett SM, Burks EJ, Mazzilli SA, Lenburg ME, Beane JE. Archetype analysis of lung adenocarcinoma premalignancy links heterogeneity in premalignant lesions to diverging features of invasive disease. bioRxiv. 2025 Oct 06.View Related Profiles.

Spira, Avrum
Burks, Eric
Kane, Erin
Lenburg, Marc
Mazzilli, Sarah

PMID: 41278661; PMCID: PMC12632533; DOI: 10.1101/2025.10.04.680402;

Ning B, Chiu DJ, Pfefferkorn RM, Kefella Y, Kane E, Reyes-Ortiz V, Liu G, Zhang S, Liu H, Sultan L, Green E, Constant M, Spira AE, Campbell JD, Reid ME, Varelas X, Burks EJ, Lenburg ME, Mazzilli SA, Beane JE. Epithelial miR-149-5p up-regulation is associated with immune evasion in progressive bronchial premalignant lesions. bioRxiv. 2025 Feb 05.View Related Profiles.

Spira, Avrum
Beane-Ebel, Jennifer
Lenburg, Marc
Mazzilli, Sarah

PMID: 39975222; PMCID: PMC11838605; DOI: 10.1101/2025.02.03.636307;

Steiner D, Sultan L, Sullivan T, Liu H, Zhang S, LeClerc A, Alekseyev YO, Liu G, Mazzilli SA, Zhang J, Rieger-Christ K, Burks EJ, Beane J, Lenburg ME. Identification of a gene expression signature of vascular invasion and recurrence in stage I lung adenocarcinoma via bulk and spatial transcriptomics. bioRxiv. 2024 Jun 10.View Related Profiles.

Steiner, Dylan
Beane-Ebel, Jennifer
Lenburg, Marc
Mazzilli, Sarah
Alekseyev, Yuriy

PMID: 38915565; PMCID: PMC11195124; DOI: 10.1101/2024.06.07.597993;

Steiner D, Park JA, Singh S, Potter A, Scalera J, Beane J, Suzuki K, Lenburg ME, Burks EJ. A computed tomography-based score indicative of lung cancer aggression (SILA) predicts lung adenocarcinomas with low malignant potential or vascular invasion. Cancer Biomark. 2025 Jan; 42(1):CBM230456.View Related Profiles.

Burks, Eric
Beane-Ebel, Jennifer
Lenburg, Marc

PMID: 39058440; PMCID: PMC12226792; DOI: 10.3233/CBM-230456;

Showing 10 of 212 results. Show More

Menon AA, Lee M, Ke X, Putman RK, Hino T, Rose JA, Duan F, Ash SY, Cho MH, O'Connor GT, Dupuis J, Hatabu H, Lenburg ME, Billatos ES, Hunninghake GM. Bronchial epithelial gene expression and interstitial lung abnormalities. Respir Res. 2023 Oct 10; 24(1):245.View Related Profiles.

Billatos, Ehab
O'Connor, George
Dupuis, Josee
Lenburg, Marc

PMID: 37817229; PMCID: PMC10566143; DOI: 10.1186/s12931-023-02536-w;

Yanagawa J, Tran LM, Salehi-Rad R, Lim RJ, Dumitras C, Fung E, Wallace WD, Prosper AE, Fishbein G, Shea C, Hong R, Kahangi B, Deng JJ, Gower AC, Liu B, Campbell JD, Mazzilli SA, Beane JE, Kadara H, Lenburg ME, Spira AE, Aberle DR, Krysan K, Dubinett SM. Single-Cell Characterization of Pulmonary Nodules Implicates Suppression of Immunosurveillance across Early Stages of Lung Adenocarcinoma. Cancer Res. 2023 Oct 02; 83(19):3305-3319.View Related Profiles.

Gower, Adam
Spira, Avrum
Beane-Ebel, Jennifer
Campbell, Joshua
Lenburg, Marc
Mazzilli, Sarah

PMID: 37477508; PMCID: PMC10544016; DOI: 10.1158/0008-5472.CAN-23-0128;

Pavel AB, Garrison C, Luo L, Liu G, Taub D, Xiao J, Juan-Guardela B, Tedrow J, Alekseyev YO, Yang IV, Geraci MW, Sciurba F, Schwartz DA, Kaminski N, Beane J, Spira A, Lenburg ME, Campbell JD. Integrative genetic and genomic networks identify microRNA associated with COPD and ILD. Sci Rep. 2023 Aug 11; 13(1):13076.View Related Profiles.

Spira, Avrum
Taub, Daniel
Liu, Gang
Beane-Ebel, Jennifer
Tedrow, John
Campbell, Joshua
Luo, Lingqi
Lenburg, Marc
Alekseyev, Yuriy

PMID: 37567908; PMCID: PMC10421936; DOI: 10.1038/s41598-023-39751-w;

Paez R, Kammer MN, Tanner NT, Shojaee S, Heideman BE, Peikert T, Balbach ML, Iams WT, Ning B, Lenburg ME, Mallow C, Yarmus L, Fong KM, Deppen S, Grogan EL, Maldonado F. Update on Biomarkers for the Stratification of Indeterminate Pulmonary Nodules. Chest. 2023 Oct; 164(4):1028-1041. PMID: 37244587; PMCID: PMC10645597; DOI: 10.1016/j.chest.2023.05.025;

Ning B, Tilston-Lunel AM, Simonetti J, Hicks-Berthet J, Matschulat A, Pfefferkorn R, Spira A, Edwards M, Mazzilli S, Lenburg ME, Beane JE, Varelas X. Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression. J Exp Clin Cancer Res. 2023 May 08; 42(1):116.View Related Profiles.

Tilston-Lunel, Andrew
Spira, Avrum
Beane-Ebel, Jennifer
Lenburg, Marc
Pfefferkorn, Roxana
Mazzilli, Sarah
Varelas, Xaralabos

PMID: 37150829; PMCID: PMC10165825; DOI: 10.1186/s13046-023-02674-5;

Kammer MN, Mori H, Rowe DJ, Chen SC, Vasiukov G, Atwater T, Senosain MF, Antic S, Zou Y, Chen H, Peikert T, Deppen S, Grogan EL, Massion PP, Dubinett S, Lenburg M, Borowsky A, Maldonado F. Tumoral Densities of T-Cells and Mast Cells Are Associated With Recurrence in Early-Stage Lung Adenocarcinoma. JTO Clin Res Rep. 2023 Sep; 4(9):100504. PMID: 37674811; PMCID: PMC10477685; DOI: 10.1016/j.jtocrr.2023.100504;

Xu K, Diaz AA, Duan F, Lee M, Xiao X, Liu H, Liu G, Cho MH, Gower AC, Alekseyev YO, Spira A, Aberle DR, Washko GR, Billatos E, Lenburg ME. Bronchial gene expression alterations associated with radiological bronchiectasis. Eur Respir J. 2023 Jan; 61(1).View Related Profiles.

Gower, Adam
Spira, Avrum
Billatos, Ehab
Liu, Gang
Liu, Hanqiao
Lenburg, Marc
Alekseyev, Yuriy

PMID: 36229050; PMCID: PMC9881226; DOI: 10.1183/13993003.00120-2022;

Kern JG, Tilston-Lunel AM, Federico A, Ning B, Mueller A, Peppler GB, Stampouloglou E, Cheng N, Johnson RL, Lenburg ME, Beane JE, Monti S, Varelas X. Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas. Nat Commun. 2022 Nov 28; 13(1):7198.View Related Profiles.

Tilston-Lunel, Andrew
Stampouloglou, Eleni
Beane-Ebel, Jennifer
Kern, Joseph
Lenburg, Marc
Monti, Stefano
Varelas, Xaralabos

PMID: 36443313; PMCID: PMC9705439; DOI: 10.1038/s41467-022-34864-8;

Moreira JD, Gower AC, Xue L, Alekseyev Y, Smith KK, Choi SH, Ayalon N, Farb MG, Tenan K, LeClerc A, Levy D, Benjamin EJ, Lenburg ME, Mitchell RN, Padera RF, Fetterman JL, Gopal DM. Systematic dissection, preservation, and multiomics in whole human and bovine hearts. Cardiovasc Pathol. 2023; 63:107495.View Related Profiles.

Gower, Adam
Gopal, Deepa
Benjamin, Emelia
Moreira, Jesse
Fetterman, Jessica
Lenburg, Marc
Farb, Melissa
Ayalon, Nir
Alekseyev, Yuriy

PMID: 36334690; PMCID: PMC10031913; DOI: 10.1016/j.carpath.2022.107495;

Xu K, Shi X, Husted C, Hong R, Wang Y, Ning B, Sullivan TB, Rieger-Christ KM, Duan F, Marques H, Gower AC, Xiao X, Liu H, Liu G, Duclos G, Platt M, Spira AE, Mazzilli SA, Billatos E, Lenburg ME, Campbell JD, Beane JE. Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways. Sci Rep. 2022 Oct 28; 12(1):18168.View Related Profiles.

Gower, Adam
Spira, Avrum
Billatos, Ehab
Liu, Gang
Duclos, Grant
Liu, Hanqiao
Beane-Ebel, Jennifer
Campbell, Joshua
Lenburg, Marc
Platt, Michael
Mazzilli, Sarah

PMID: 36307504; PMCID: PMC9615627; DOI: 10.1038/s41598-022-17832-6;

Xu F, Vasilescu DM, Kinose D, Tanabe N, Ng KW, Coxson HO, Cooper JD, Hackett TL, Verleden SE, Vanaudenaerde BM, Stevenson CS, Lenburg ME, Spira A, Tan WC, Sin DD, Ng RT, Hogg JC. The molecular and cellular mechanisms associated with the destruction of terminal bronchioles in COPD. Eur Respir J. 2022 May; 59(5).View Related Profiles.

Spira, Avrum
Lenburg, Marc

PMID: 34675046

You X, Dadwal UC, Lenburg ME, Kacena MA, Charles JF. Murine Gut Microbiome Meta-analysis Reveals Alterations in Carbohydrate Metabolism in Response to Aging. mSystems. 2022 Apr 26; 7(2):e0124821. PMID: 35400171; PMCID: PMC9040766; DOI: 10.1128/msystems.01248-21;

Lu D, Demissie S, Horowitz NB, Gower AC, Lenburg ME, Alekseyev YO, Hussein AI, Bragdon B, Liu Y, Daukss D, Page JM, Webster MZ, Schlezinger JJ, Morgan EF, Gerstenfeld LC. Temporal and Quantitative Transcriptomic Differences Define Sexual Dimorphism in Murine Postnatal Bone Aging. JBMR Plus. 2022 Feb; 6(2):e10579.View Related Profiles.

Gower, Adam
Hussein, Amira
Bragdon, Beth
Morgan, Elise
Schlezinger, Jennifer
Gerstenfeld, Louis
Lenburg, Marc
Demissie, Serkalem
Alekseyev, Yuriy

PMID: 35229061; PMCID: PMC8861981; DOI: 10.1002/jbm4.10579;

Burks EJ, Zhang J, Sullivan TB, Shi X, Sands JM, Regis SM, McKee BJ, McKee AB, Zhang S, Liu H, Liu G, Spira A, Beane J, Lenburg ME, Rieger-Christ KM. Pathologic and gene expression comparison of CT- screen detected and routinely detected stage I/0 lung adenocarcinoma in NCCN risk-matched cohorts. Cancer Treat Res Commun. 2021; 29:100486.View Related Profiles.

Spira, Avrum
Burks, Eric
Beane-Ebel, Jennifer
Lenburg, Marc

PMID: 34794107; PMCID: PMC8713084; DOI: 10.1016/j.ctarc.2021.100486;

Xu K, Shi X, Husted C, Hong R, Wang Y, Ning B, Sullivan T, Rieger-Christ K, Duan F, Marques H, Gower A, Xiao X, Liu H, Liu G, Duclos G, Platt M, Spira A, Mazzilli S, Billatos E, Lenburg M, Campbell J, Beane J. Smoking Modulates Different Secretory Subpopulations Expressing SARS-CoV-2 Entry Genes in the Nasal and Bronchial Airways. Res Sq. 2021 Oct 28.View Related Profiles.

Gower, Adam
Spira, Avrum
Billatos, Ehab
Liu, Gang
Duclos, Grant
Liu, Hanqiao
Beane-Ebel, Jennifer
Campbell, Joshua
Lenburg, Marc
Platt, Michael
Mazzilli, Sarah

PMID: 34729557; PMCID: PMC8562543; DOI: 10.21203/rs.3.rs-887718/v1;

Maoz A, Merenstein C, Koga Y, Potter A, Gower AC, Liu G, Zhang S, Liu H, Stevenson C, Spira A, Reid ME, Campbell JD, Mazzilli SA, Lenburg ME, Beane J. Elevated T cell repertoire diversity is associated with progression of lung squamous cell premalignant lesions. J Immunother Cancer. 2021 09; 9(9).View Related Profiles.

Gower, Adam
Spira, Avrum
Liu, Gang
Liu, Hanqiao
Beane-Ebel, Jennifer
Campbell, Joshua
Lenburg, Marc
Mazzilli, Sarah

PMID: 34580161; PMCID: PMC8477334; DOI: 10.1136/jitc-2021-002647;

Hicks-Berthet J, Ning B, Federico A, Tilston-Lunel A, Matschulat A, Ai X, Lenburg ME, Beane J, Monti S, Varelas X. Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis. Cell Rep. 2021 07 13; 36(2):109347.View Related Profiles.

Tilston-Lunel, Andrew
Beane-Ebel, Jennifer
Lenburg, Marc
Monti, Stefano
Varelas, Xaralabos
Ai, Xingbin

PMID: 34260916; PMCID: PMC8346236; DOI: 10.1016/j.celrep.2021.109347;

Becker EJ, Faiz A, van den Berge M, Timens W, Hiemstra PS, Clark K, Liu G, Xiao X, Alekseyev YO, O'Connor G, Lam S, Spira A, Lenburg ME, Steiling K. Bronchial gene expression signature associated with rate of subsequent FEV1 decline in individuals with and at risk of COPD. Thorax. 2022 01; 77(1):31-39.View Related Profiles.

Spira, Avrum
Liu, Gang
O'Connor, George
Steiling, Katrina
Lenburg, Marc
Alekseyev, Yuriy

PMID: 33972452

Xu F, Tanabe N, Vasilescu DM, McDonough JE, Coxson HO, Ikezoe K, Kinose D, Ng KW, Verleden SE, Wuyts WA, Vanaudenaerde BM, Verschakelen J, Cooper JD, Lenburg ME, Morshead KB, Abbas AR, Arron JR, Spira A, Hackett TL, Colby TV, Ryerson CJ, Ng RT, Hogg JC. The transition from normal lung anatomy to minimal and established fibrosis in idiopathic pulmonary fibrosis (IPF). EBioMedicine. 2021 Apr; 66:103325.View Related Profiles.

Spira, Avrum
Lenburg, Marc

PMID: 33862585; PMCID: PMC8054143; DOI: 10.1016/j.ebiom.2021.103325;

Choi Y, Qu J, Wu S, Hao Y, Zhang J, Ning J, Yang X, Lofaro L, Pankratz DG, Babiarz J, Walsh PS, Billatos E, Lenburg ME, Kennedy GC, McAuliffe J, Huang J. Improving lung cancer risk stratification leveraging whole transcriptome RNA sequencing and machine learning across multiple cohorts. BMC Med Genomics. 2020 10 22; 13(Suppl 10):151.View Related Profiles.

Billatos, Ehab
Lenburg, Marc

PMID: 33087128; PMCID: PMC7579926; DOI: 10.1186/s12920-020-00782-1;

Faiz A, Imkamp K, van der Wiel E, Boudewijn IM, Koppelman GH, Brandsma CA, Kerstjens HAM, Timens W, Vroegop S, Pasma HR, Boersma WG, Wielders P, van den Elshout F, Mansour K, Steiling K, Spira A, Lenburg ME, Heijink IH, Postma DS, van den Berge M. Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD. Sci Rep. 2020 10 15; 10(1):17415.View Related Profiles.

Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 33060632; PMCID: PMC7562702; DOI: 10.1038/s41598-020-72551-0;

Billatos E, Ash SY, Duan F, Xu K, Romanoff J, Marques H, Moses E, Han MK, Regan EA, Bowler RP, Mason SE, Doyle TJ, San José Estépar R, Rosas IO, Ross JC, Xiao X, Liu H, Liu G, Sukumar G, Wilkerson M, Dalgard C, Stevenson C, Whitney D, Aberle D, Spira A, San José Estépar R, Lenburg ME, Washko GR. Distinguishing Smoking-Related Lung Disease Phenotypes Via Imaging and Molecular Features. Chest. 2021 02; 159(2):549-563.View Related Profiles.

Spira, Avrum
Billatos, Ehab
Lenburg, Marc

PMID: 32946850; PMCID: PMC8039011; DOI: 10.1016/j.chest.2020.08.2115;

Drizik E, Corbett S, Zheng Y, Vermeulen R, Dai Y, Hu W, Ren D, Duan H, Niu Y, Xu J, Fu W, Meliefste K, Zhou B, Zhang X, Yang J, Bassig B, Liu H, Ye M, Liu G, Jia X, Meng T, Bin P, Zhang J, Silverman D, Spira A, Rothman N, Lenburg ME, Lan Q. Transcriptomic changes in the nasal epithelium associated with diesel engine exhaust exposure. Environ Int. 2020 04; 137:105506.View Related Profiles.

Spira, Avrum
Liu, Gang
Liu, Hanqiao
Lenburg, Marc
Dai, Yan

PMID: 32044442; PMCID: PMC8725607; DOI: 10.1016/j.envint.2020.105506;

Hickson LJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q, Jordan KL, Kellogg TA, Khosla S, Koerber DM, Lagnado AB, Lawson DK, LeBrasseur NK, Lerman LO, McDonald KM, McKenzie TJ, Passos JF, Pignolo RJ, Pirtskhalava T, Saadiq IM, Schaefer KK, Textor SC, Victorelli SG, Volkman TL, Xue A, Wentworth MA, Wissler Gerdes EO, Allison DB, Dickinson SL, Ejima K, Atkinson EJ, Lenburg M, Zhu Y, Tchkonia T, Kirkland JL. Corrigendum to 'Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease' EBioMedicine 47 (2019) 446-456. EBioMedicine. 2020 Feb; 52:102595. PMID: 31982828; PMCID: PMC6994619; DOI: 10.1016/j.ebiom.2019.12.004;

Duclos GE, Teixeira VH, Autissier P, Gesthalter YB, Reinders-Luinge MA, Terrano R, Dumas YM, Liu G, Mazzilli SA, Brandsma CA, van den Berge M, Janes SM, Timens W, Lenburg ME, Spira A, Campbell JD, Beane J. Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution. Sci Adv. 2019 12; 5(12):eaaw3413.View Related Profiles.

Spira, Avrum
Liu, Gang
Duclos, Grant
Beane-Ebel, Jennifer
Campbell, Joshua
Lenburg, Marc
Mazzilli, Sarah
Dumas, Yves-Martine

PMID: 31844660; PMCID: PMC6905872; DOI: 10.1126/sciadv.aaw3413;

Corbett SE, Nitzberg M, Moses E, Kleerup E, Wang T, Perdomo C, Perdomo C, Liu G, Xiao X, Liu H, Elashoff DA, Brooks DR, O'Connor GT, Dubinett SM, Spira A, Lenburg ME. Gene Expression Alterations in the Bronchial Epithelium of e-Cigarette Users. Chest. 2019 10; 156(4):764-773.View Related Profiles.

Spira, Avrum
Brooks, Daniel
Moses, Elizabeth
Liu, Gang
O'Connor, George
Liu, Hanqiao
Lenburg, Marc

PMID: 31233743; PMCID: PMC6859252; DOI: 10.1016/j.chest.2019.05.022;

Hijazi K, Malyszko B, Steiling K, Xiao X, Liu G, Alekseyev YO, Dumas YM, Hertsgaard L, Jensen J, Hatsukami D, Brooks DR, O'Connor G, Beane J, Lenburg ME, Spira A. Tobacco-Related Alterations in Airway Gene Expression are Rapidly Reversed Within Weeks Following Smoking-Cessation. Sci Rep. 2019 05 06; 9(1):6978.View Related Profiles.

Spira, Avrum
Brooks, Daniel
Liu, Gang
O'Connor, George
Beane-Ebel, Jennifer
Steiling, Katrina
Lenburg, Marc
Alekseyev, Yuriy
Dumas, Yves-Martine

PMID: 31061400; PMCID: PMC6502805; DOI: 10.1038/s41598-019-43295-3;

Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, Eijgenraam TR, Jonker MR, Koppelman GH, Pouwels SD, Liu G, Alekseyev YO, Lam S, Hiemstra PS, Sterk PJ, Timens W, Brandsma CA, Heijink IH, van den Berge M. Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD. Eur Respir J. 2019 04; 53(4).View Related Profiles.

Spira, Avrum
Steiling, Katrina
Lenburg, Marc
Alekseyev, Yuriy

PMID: 30846474

Beane JE, Mazzilli SA, Campbell JD, Duclos G, Krysan K, Moy C, Perdomo C, Schaffer M, Liu G, Zhang S, Liu H, Vick J, Dhillon SS, Platero SJ, Dubinett SM, Stevenson C, Reid ME, Lenburg ME, Spira AE. Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions. Nat Commun. 2019 04 23; 10(1):1856.View Related Profiles.

Spira, Avrum
Liu, Gang
Duclos, Grant
Liu, Hanqiao
Beane-Ebel, Jennifer
Campbell, Joshua
Lenburg, Marc
Mazzilli, Sarah

PMID: 31015447; PMCID: PMC6478943; DOI: 10.1038/s41467-019-09834-2;

Billatos E, Faiz A, Gesthalter Y, LeClerc A, Alekseyev YO, Xiao X, Liu G, Ten Hacken NHT, Heijink IH, Timens W, Brandsma CA, Postma DS, van den Berge M, Spira A, Lenburg ME. Impact of acute exposure to cigarette smoke on airway gene expression. Physiol Genomics. 2018 09 01; 50(9):705-713.View Related Profiles.

Spira, Avrum
Billatos, Ehab
Liu, Gang
Lenburg, Marc
Alekseyev, Yuriy

PMID: 29932825; PMCID: PMC6172616; DOI: 10.1152/physiolgenomics.00092.2017;

Billatos E, Vick JL, Lenburg ME, Spira AE. The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection. Clin Cancer Res. 2018 07 01; 24(13):2984-2992.View Related Profiles.

Spira, Avrum
Billatos, Ehab
Lenburg, Marc

PMID: 29463557; PMCID: PMC7397497; DOI: 10.1158/1078-0432.CCR-16-3187;

Mazzilli SA, Zhang S, Liu G, Lenburg M, Spira A, Beane J. Abstract B18: The carcinogen-induced NTCU model: A preclinical mouse model for lung cancer interception. Cancer Research. 2018; 78(10 suppl):B18. View Publication

Boudewijn IM, Faiz A, Steiling K, van der Wiel E, Telenga ED, Hoonhorst SJM, Ten Hacken NHT, Brandsma CA, Kerstjens HAM, Timens W, Heijink IH, Jonker MR, de Bruin HG, Sebastiaan Vroegop J, Pasma HR, Boersma WG, Wielders P, van den Elshout F, Mansour K, Spira A, Lenburg ME, Guryev V, Postma DS, van den Berge M. Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression. Respir Res. 2017 12 21; 18(1):213.View Related Profiles.

Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 29268739; PMCID: PMC5740586; DOI: 10.1186/s12931-017-0696-5;

Ong J, Timens W, Rajendran V, Algra A, Spira A, Lenburg ME, Campbell JD, van den Berge M, Postma DS, van den Berg A, Kluiver J, Brandsma CA. Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts. PLoS One. 2017; 12(9):e0183815.View Related Profiles.

Spira, Avrum
Campbell, Joshua
Lenburg, Marc

PMID: 28910321; PMCID: PMC5599028; DOI: 10.1371/journal.pone.0183815;

Pavel AB, Campbell JD, Liu G, Elashoff D, Dubinett S, Smith K, Whitney D, Lenburg ME, Spira A. Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection. Cancer Prev Res (Phila). 2017 Nov; 10(11):651-659.View Related Profiles.

Spira, Avrum
Liu, Gang
Campbell, Joshua
Lenburg, Marc

PMID: 28877936; PMCID: PMC6758560; DOI: 10.1158/1940-6207.CAPR-17-0098;

Suzuki M, Sze MA, Campbell JD, Brothers JF, Lenburg ME, McDonough JE, Elliott WM, Cooper JD, Spira A, Hogg JC. The cellular and molecular determinants of emphysematous destruction in COPD. Sci Rep. 2017 08 25; 7(1):9562.View Related Profiles.

Spira, Avrum
Campbell, Joshua
Lenburg, Marc

PMID: 28842670; PMCID: PMC5573394; DOI: 10.1038/s41598-017-10126-2;

Shared Gene Expression Alterations in Nasal and Bronchial Epithelium for Lung Cancer Detection. J Natl Cancer Inst. 2017 Jul 01; 109(7).View Related Profiles.

Lenburg, Marc
Johnson, William

PMID: 28376173; PMCID: PMC6059169; DOI: 10.1093/jnci/djw327;

Beane J, Mazzilli SA, Tassinari AM, Liu G, Zhang X, Liu H, Buncio AD, Dhillon SS, Platero SJ, Lenburg ME, Reid ME, Lam S, Spira AE. Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression. Clin Cancer Res. 2017 Sep 01; 23(17):5091-5100.View Related Profiles.

Spira, Avrum
Liu, Gang
Liu, Hanqiao
Beane-Ebel, Jennifer
Lenburg, Marc
Mazzilli, Sarah

PMID: 28533227; PMCID: PMC7404813; DOI: 10.1158/1078-0432.CCR-16-2540;

Hu Z, Mao JH, Curtis C, Huang G, Gu S, Heiser L, Lenburg ME, Korkola JE, Bayani N, Samarajiwa S, Seoane JA, Dane MA, Esch A, Feiler HS, Wang NJ, Hardwicke MA, Laquerre S, Jackson J, Wood KW, Weber B, Spellman PT, Aparicio S, Wooster R, Caldas C, Gray JW. Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer. Breast Cancer Res. 2017 02 09; 19(1):17. PMID: 28183333; PMCID: PMC5301377; DOI: 10.1186/s13058-017-0809-6;

Campbell J, Zhang X, Singh Dhillon S, Perdomo C, Mazzilli SA, Geshalter Y, Liu G, Zhang S, Lin H, Vick J, Moy C, Monti S, Johnson E, Meyerson M, Dubinett S, Platero S, Wilkerson M, Dalgard C, Lenburg ME, Reid M, Beane J, Spira A. Abstract 3259: The genomic landscape of premalignant lung squamous cell carcinoma lesions. Cancer Research. 2017; 77(13 suppl):3259. View Publication
Beane JE, Mazzilli SA, Campbell J, Moy C, Schaffer M, Perdomo C, Jenkins D, Liu G, Zhang S, Liu H, Vick J, Johnson E, Platero S, Lenburg ME, Reid M, Singh Dhillon S, Spira A. Abstract 5002: Premalignant squamous cell lung carcinoma lesions have distinct molecular subtypes associated with histologic progression. Cancer Research. 2017; 77(13 suppl):5002. View Publication
Lee HJ, Whitten P, Bhadra K, Dotson T, Hogarth DK, Benzaquen S, Pritchett M, Gordon J, Bedekar A, Esterle M, Smith K, Bianchi P, Lenburg ME, Spira A. Prospective Utility of a Bronchial Genomic Classifier for Lung Cancer Detection: Interim Results From a Multicenter Prospective Registry. Chest. 2017; 152(4):A625. View Publication
Ong J, Timens W, Rajendran V, Algra A, Spira A, Lenburg ME, Campbell J, van den Berge M, Postma D, van den Berg A, Kluvier J, Brandsma CA. ERS International Congress 2017 abstracts. Target gene identification of TGF-ß-induced miR-455-3p and miR-21-3p in lung fibroblasts. 2017. View Publication
Mazzilli SA, Tassinari A, Xiao X, Liu G, Singh Dhillon S, Johnson CS, Reid M, Lenburg M, Spira A, Beane J. Abstract 1252: A pre-clinical model for lung cancer interception: gene expression similarities between human and mouse bronchial premalignant lesions. Cancer Research. 2017; 77(13 suppl):1252. View Publication
Duclos GE, Campbell JD, Gesthalther Y, Autissier P, Dumas YM, Terrano R, Liu G, Lenburg ME, Spira A, Beane J. Abstract 1433: Single cell RNA sequencing reveals smoking-associated alterations in bronchial airway epithelial subpopulations. Cancer Research. 2017; 77(13 suppl):1433. View Publication
Drizik E, Corbett S, Vermeulen R, Dai Y, Hu W, Lenburg ME, Ren D, Duan H, Niu Y, Xu J, Fu W, Meliefste K, Zhou B, Yang JF, Ye M, Jia X, Meng T, Bin P, Zheng Y, Silverman D, Rothman N, Spira A, Lan Q. Abstract 4256: Impact of diesel engine exhaust exposure on the airway transcriptome. Cancer Research. 2017; 77(13 suppl):4256. View Publication

Vasilescu DM, Phillion AB, Tanabe N, Kinose D, Paige DF, Kantrowitz JJ, Liu G, Liu H, Fishbane N, Verleden SE, Vanaudenaerde BM, Lenburg M, Stevenson CS, Spira A, Cooper JD, Hackett TL, Hogg JC. Nondestructive cryomicro-CT imaging enables structural and molecular analysis of human lung tissue. J Appl Physiol (1985). 2017 Jan 01; 122(1):161-169.View Related Profiles.

Spira, Avrum
Liu, Gang
Lenburg, Marc

PMID: 27856720; PMCID: PMC6442661; DOI: 10.1152/japplphysiol.00838.2016;

Kusko RL, Brothers JF, Tedrow J, Pandit K, Huleihel L, Perdomo C, Liu G, Juan-Guardela B, Kass D, Zhang S, Lenburg M, Martinez F, Quackenbush J, Sciurba F, Limper A, Geraci M, Yang I, Schwartz DA, Beane J, Spira A, Kaminski N. Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016 Oct 15; 194(8):948-960.View Related Profiles.

Spira, Avrum
Liu, Gang
Beane-Ebel, Jennifer
Tedrow, John
Lenburg, Marc
Kusko, Rebecca

PMID: 27104832; PMCID: PMC5067817; DOI: 10.1164/rccm.201510-2026OC;

Moses E, Wang T, Corbett S, Jackson GR, Drizik E, Perdomo C, Perdomo C, Kleerup E, Brooks D, O'Connor G, Dubinett S, Hayden P, Lenburg ME, Spira A. Molecular Impact of Electronic Cigarette Aerosol Exposure in Human Bronchial Epithelium. Toxicol Sci. 2017 Jan; 155(1):248-257.View Related Profiles.

Spira, Avrum
Brooks, Daniel
Moses, Elizabeth
O'Connor, George
Lenburg, Marc

PMID: 27701119; PMCID: PMC5216655; DOI: 10.1093/toxsci/kfw198;

Lam S, Mandrekar SJ, Gesthalter Y, Allen Ziegler KL, Seisler DK, Midthun DE, Mao JT, Aubry MC, McWilliams A, Sin DD, Shaipanich T, Liu G, Johnson E, Bild A, Lenburg ME, Ionescu DN, Mayo J, Yi JE, Tazelaar H, Harmsen WS, Smith J, Spira AE, Beane J, Limburg PJ, Szabo E. A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia. Cancer Prev Res (Phila). 2016 Dec; 9(12):906-914.View Related Profiles.

Spira, Avrum
Liu, Gang
Beane-Ebel, Jennifer
Lenburg, Marc
Johnson, William

PMID: 27658890; PMCID: PMC5136333; DOI: 10.1158/1940-6207.CAPR-15-0254;

Hu Z, Mao JH, Curtis C, Huang G, Gu S, Heiser L, Lenburg ME, Korkola JE, Bayani N, Samarajiwa S, Seoane JA, A Dane M, Esch A, Feiler HS, Wang NJ, Hardwicke MA, Laquerre S, Jackson J, W Wood K, Weber B, Spellman PT, Aparicio S, Wooster R, Caldas C, Gray JW. Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer. Breast Cancer Res. 2016 Jul 01; 18(1):70. PMID: 27368372; PMCID: PMC4930593; DOI: 10.1186/s13058-016-0728-y;

Vachani A, Whitney DH, Parsons EC, Lenburg M, Ferguson JS, Silvestri GA, Spira A. Clinical Utility of a Bronchial Genomic Classifier in Patients With Suspected Lung Cancer. Chest. 2016 Jul; 150(1):210-8.View Related Profiles.

Spira, Avrum
Lenburg, Marc

PMID: 26896702; DOI: 10.1016/j.chest.2016.02.636;

Vasilescu DM, Phillion AB, Tanabe N, Kinose D, Paige DF, Kantrowitz J, Liu G, Liu H, Fishbane N, Verleden SE, Vanaudenaerde BM, Leburg ME, Stevenson CS, Spira A, Cooper JD, Hackett TL, Hogg JC. Non-destructive cryo micro CT imaging enables structural and molecular analysis of human lung tissue. Journal of Applied Physiology. 2016; 122(1). View Publication
Reed E, Bray D, Lam S, van den Berge M, Liu G, Zhang X, Alekseyev Y, Spira A, Lenburg M, Steiling K. Data-Driven Identification of Novel Molecular Subclasses of COPD. Chest. 2016; 150(4):916A. View Publication
Becker E, Lam S, van den Berge M, Liu G, Zhang X, Alekseyev Y, Spira A, Lenburg M, Steiling K. Predicting Lung Function Decline in COPD Using Bronchial Airway Gene Expression. Chest. 2016; 150(4):912A. View Publication
Hogarth DK, Dotson T, Lee H, Whitten P, Lenburg M. The Percepta Registry: A Prospective Registry to Evaluate Percepta Bronchial Genomic Classifier Patient Data. Chest. 2016; 150(4):1026A. View Publication
Imkamp K, Faiz A, van der Wiel E, Boudewijn IM, Koppelman GH, Brandsma CA, Kerstjens H, Timens W, Vroegop S, Pasma H, Boersma WG, Wielders P, van den Elshout F, Mansour K, Steiling K, Spira A, Lenburg M, Heijink IH, Postma D, van den Berge M. Effects of ICS/LABA treatment on hyperinflation and genome wide gene-expression in upper airway epithelium in severe COPD. European Respiratory Journal. 2016; 48(suppl 60):PA 1203. View Publication
Campbell JD, Perdomo C, Mazzilli SA, Geshalter Y, Singh Dhillon S, Liu G, Zhang S, Lin H, Vick J, Moy C, Johnson E, Meyerson M, Platero S, Lenburg M, Reid M, Spira A, Beane J. Abstract 895: Genomic characterization of premalignant lung squamous cell carcinoma lesions. Cancer Research. 2016; 76(14 suppl):895. View Publication
Pavel A, Campbell J, Liu G, Zhang S, Liu H, Xiao J, Porta Smith K, Whitney D, Dubinett S, Elashoff D, Lenburg ME, Spira A. Abstract 1954: microRNA expression in bronchial epithelium for lung cancer detection. Cancer Research. 2016; 76(14 suppl):1954. View Publication
Park SJ, Walser T, Tran LM, Perdomo C, Wang T, Long-Sheng H, Pagano P, Li R, Jing Z, Liclican E, Larsen JE, Krysan K, Fishbein MC, Minna J, Lenburg ME, Spira A, Dubinett SM. The biological impact of e-cigarettes on airway epithelial cell transformation and gene expression. Journal of Thoracic Oncology. 2016; 11(2):S35-S36. View Publication
Mazzilli SA, Tassinari A, Gethalter Y, Lui G, Pine M, Lam S, Reid M, Platero S, Lenburg ME, Spira A, Beane J . Abstract 896: The airway field of injury reflects gene expression changes associated with the presence of lung squamous premalignant lesions. Cancer Research. 2016; 76(14 suppl):896. View Publication

Wang TW, Vermeulen RC, Hu W, Liu G, Xiao X, Alekseyev Y, Xu J, Reiss B, Steiling K, Downward GS, Silverman DT, Wei F, Wu G, Li J, Lenburg ME, Rothman N, Spira A, Lan Q. Gene-expression profiling of buccal epithelium among non-smoking women exposed to household air pollution from smoky coal. Carcinogenesis. 2015 Dec; 36(12):1494-501.View Related Profiles.

Spira, Avrum
Liu, Gang
Steiling, Katrina
Lenburg, Marc
Alekseyev, Yuriy

PMID: 26468118; PMCID: PMC4675833; DOI: 10.1093/carcin/bgv150;

Sze MA, Dimitriu PA, Suzuki M, McDonough JE, Campbell JD, Brothers JF, Erb-Downward JR, Huffnagle GB, Hayashi S, Elliott WM, Cooper J, Sin DD, Lenburg ME, Spira A, Mohn WW, Hogg JC. Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2015 Aug 15; 192(4):438-45.View Related Profiles.

Spira, Avrum
Campbell, Joshua
Lenburg, Marc

PMID: 25945594; PMCID: PMC4595667; DOI: 10.1164/rccm.201502-0223OC;

Silvestri GA, Vachani A, Whitney D, Elashoff M, Porta Smith K, Ferguson JS, Parsons E, Mitra N, Brody J, Lenburg ME, Spira A. A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer. N Engl J Med. 2015 Jul 16; 373(3):243-51.View Related Profiles.

Spira, Avrum
Brody, Jerome
Lenburg, Marc

PMID: 25981554; PMCID: PMC4838273; DOI: 10.1056/NEJMoa1504601;

Whitney DH, Elashoff MR, Porta-Smith K, Gower AC, Vachani A, Ferguson JS, Silvestri GA, Brody JS, Lenburg ME, Spira A. Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy. BMC Med Genomics. 2015; 8:18.View Related Profiles.

Gower, Adam
Spira, Avrum
Brody, Jerome
Lenburg, Marc

PMID: 25944280; PMCID: PMC4434538; DOI: 10.1186/s12920-015-0091-3;

Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015 Aug; 14(4):644-58.View Related Profiles.

Gower, Adam
Lenburg, Marc

PMID: 25754370; PMCID: PMC4531078; DOI: 10.1111/acel.12344;

Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG. Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015 Apr 1; 191(7):758-66.View Related Profiles.

Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 25611785; PMCID: PMC4407484; DOI: 10.1164/rccm.201408-1458OC;

Beane JE, Campbell J, Moy C, Perdomo C, Schaffer M, Mazzilli SA, Geshalter Y, Kantrowitz J, Zhang L, Jenkins D, Pine M, Singh Dhillon S, Liu G, Liu H, Zhang S, Vick J, Monti S, Johnson E, Platero S, Lenburg ME, Reid M, Spira A. Abstract 2878: Development of the pre-cancer genome atlas (PCGA) for squamous cell lung carcinoma. Cancer Research. 2015; 75(15 suppl):2878. View Publication
Park SJ, Walser T, Tran LM, Perdomo C, Wang T, Long-Sheng H, Pagano P, Liclican E, Larsen JE, Krysan K, Fishbein MC, Minna J, Lenburg ME, Spira A, Dubinett S. Abstract B22: The role of e-cigarette exposure on pulmonary epithelial cell transformation. Cancer Prevention Research. 2015; 8(10 suppl):B22. View Publication
Perez-Rogers JF, Gerrein J, Anderlind C, Kusko RL, Campbell JD, Wang TW, Porta Smith K, Whitney D, Spira A, Lenburg ME. Abstract A1-66: Leveraging Gene Expression in the Bronchial Airway to Develop a Nasal Biomarker for Early Detection of Lung Cancer. Cancer Research. 2015; 75(22 suppl 1). View Publication
Tassinari A, Zhang B, Steiling K, Whitney D, Porta Smith K, Lam S, Lenburg M, Spira A, Beane J. Abstract A2-63: Airway gene-coexpression network rewiring in the presence of bronchial dysplasia and lung cancer. Cancer Research. 2015; 75(22 suppl 1):A63. View Publication
Faiz A, Borggrewe M, Postma D, Steiling K, Spira A, Lenburg ME, Jonker M, Koppelman GH, Hiemstra PS, Sterk P, Timens W, Brandsma CA, Van den Berge M, Heijink IH. MiR-320d: A novel anti-inflammatory miRNA up regulated by corticosteroids. European Respiratory Journal. 2015; 46(suppl 59). View Publication
Perez-Rogers J, Gerrein J, Xiao X, Liu H, Kusko RL, Campbell J, Wang T, Alekseyev Y, Liu G, Porta Smith K, Whitney D, Spira A, Lenburg ME. Abstract 1574: Leveraging bronchial airway gene expression to develop a nasal biomarker for lung cancer detection. Cancer Research. 2015; 75(15 suppl):1574. View Publication
Pavel A, Campbell JD, Liu G, Zhang S, Liu H, Luo L, Xiao Ji, Porta Smith K, Whitney D, Dubinett S, Elashoff D, Lenburg ME, Spira A. Abstract 3077: Dysregulation of microRNA-mRNA regulatory networks in the bronchial airway epithelium of smokers with lung cancer. Cancer Research. 2015; 75(15 suppl):3077. View Publication
Billatos E, Gesthalter Y, Hacken N, Postma D, Heijink IH, Timens W, Brandsma CA, Faiz A, Berge M, Lenburg ME, Spira A. The Impact of Acute Smoking on Airway Gene-Expression. Chest. 2015; 148:746A. View Publication
Mazzilli SA, Liu G, Zhang X, Si H, Lam S, Lenburg ME, Spira A, Beane JE. Abstract A11: Airway gene expression indicates an increase in oxidative phosphorylation in the field of injury of individuals with premalignant lesions. Cancer Prevention Research. 2015; 8(10 suppl):A11. View Publication
Vachani A, Silvestri G, Whitney D, Ferguson JS, Porta Smith K, Parson E, Brody J, Lenburg ME, Spira A. Prospective Validation of a Bronchial Genomic Classifier for Lung Cancer in Patients Undergoing Diagnostic Bronchoscopy: The AEGIS Trials. Chest. 2015; 148(4):544A. View Publication

Campbell JD, Liu G, Luo L, Xiao J, Gerrein J, Juan-Guardela B, Tedrow J, Alekseyev YO, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba F, Schwartz DA, Kaminski N, Johnson WE, Monti S, Spira A, Beane J, Lenburg ME. Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data. RNA. 2015 Feb; 21(2):164-71.View Related Profiles.

Spira, Avrum
Liu, Gang
Beane-Ebel, Jennifer
Tedrow, John
Campbell, Joshua
Luo, Lingqi
Lenburg, Marc
Monti, Stefano
Johnson, William
Alekseyev, Yuriy

PMID: 25519487; PMCID: PMC4338344; DOI: 10.1261/rna.046060.114;

Lamontagne M, Timens W, Hao K, Bossé Y, Laviolette M, Steiling K, Campbell JD, Couture C, Conti M, Sherwood K, Hogg JC, Brandsma CA, van den Berge M, Sandford A, Lam S, Lenburg ME, Spira A, Paré PD, Nickle D, Sin DD, Postma DS. Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction. Thorax. 2014 Nov; 69(11):997-1004.View Related Profiles.

Spira, Avrum
Campbell, Joshua
Steiling, Katrina
Lenburg, Marc

PMID: 25182044; DOI: 10.1136/thoraxjnl-2014-205630;

Vucic EA, Chari R, Thu KL, Wilson IM, Cotton AM, Kennett JY, Zhang M, Lonergan KM, Steiling K, Brown CJ, McWilliams A, Ohtani K, Lenburg ME, Sin DD, Spira A, Macaulay CE, Lam S, Lam WL. DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways. Am J Respir Cell Mol Biol. 2014 May; 50(5):912-22.View Related Profiles.

Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 24298892; PMCID: PMC4068945; DOI: 10.1165/rcmb.2013-0304OC;

Ooi AT, Gower AC, Zhang KX, Vick JL, Hong L, Nagao B, Wallace WD, Elashoff DA, Walser TC, Dubinett SM, Pellegrini M, Lenburg ME, Spira A, Gomperts BN. Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis. Cancer Prev Res (Phila). 2014 May; 7(5):487-95.View Related Profiles.

Gower, Adam
Spira, Avrum
Lenburg, Marc

PMID: 24618292; PMCID: PMC4059064; DOI: 10.1158/1940-6207.CAPR-13-0372;

Wolf DM, Lenburg ME, Yau C, Boudreau A, van 't Veer LJ. Gene co-expression modules as clinically relevant hallmarks of breast cancer diversity. PLoS One. 2014; 9(2):e88309. PMID: 24516633; PMCID: PMC3917875; DOI: 10.1371/journal.pone.0088309;

Krysan K, Kusko R, Grogan T, O'Hearn J, Reckamp KL, Walser TC, Garon EB, Lenburg ME, Sharma S, Spira AE, Elashoff D, Dubinett SM. PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC. Mol Cancer Res. 2014 May; 12(5):765-74.View Related Profiles.

Spira, Avrum
Lenburg, Marc
Kusko, Rebecca

PMID: 24469837; PMCID: PMC4020971; DOI: 10.1158/1541-7786.MCR-13-0377;

Park SJ, Walser T, Perdomo C, Wang T, Hong LS, Pagano PC, Liclican E, Krysan K, Larsen JE, Fishbein MC, Minna J, Lenburg ME, Spira A, Dubinett SM. Abstract 932: The impact of e-cigarette exposure on pulmonary epithelium gene expression and transformation. Cancer Research. 2014; 74(19 suppl):932. View Publication
Pavel A, Campbell J, Liu G, Zhang S, Liu H, Dubinett S, Elashoff D, Porta Smith K, Whitney D, Lenburg ME, Spira A. Abstract 1485: Biomarker development for lung cancer diagnosis using integrative microRNA and gene expression networks. Cancer Research. 2014; 74(19 suppl):1485. View Publication
Tassinari A, Whitney D, Porta Smith K, Lenburg ME, Spira A, Beane J. Abstract 1414: Race-associated variation in the airway transcriptome response to cigarette smoke. Cancer Research. 2014; 74(19 suppl):1414. View Publication
Kusko RL, LeClerc A, Swahn S, Lenburg ME, Spira A, Alekseyev Y. Comparison of Illumina and Ion Torrent RNA-Sequencing and Microarray-based approaches for Profiling the Transcriptome. Journal of biomolecular techniques: JBT. 2014; 25(suppl):s14.
Kusko RL, Anderlind C, Wang G, Zhang S, Wallace WD, Wasler T, Ebright MI, Garcia MM, Eisenberg R, Lee G, Liu G, Elashoff D, Kalhor N, Moran CA, Mehran RJ, Fujimoto J, Massion P, Dubinett S, Wistuba I, Lenburg ME, Kadara H, Spira A. Abstract 2352: Mapping the airway-wide molecular field of injury in smokers with lung cancer. Cancer Research. 2014; 74(19 suppl):2352. View Publication
Kusko RL, Garrison C, Wang T, Campbell J, Perez-Rogers J, Luo L, Beane J, Liu G, Kadara H, Belinsky S, Lenburg ME, Spira A. Abstract 3554: Gene and miRNA expression networks specific to never smoker lung adenocarcinoma. Cancer Research. 2014; 74(19 suppl):3554. View Publication
Jiwani A, Maple E, Schnall M, Mahon I, Apgar C, Browning R, More K, Morris M, Parrish JS, Atwood C, Battaile J, Garshick E, Gatsonis C, Goldstein R, Kieth R, Lenburg ME, Reid M, Remick D, Vachani A, Wistuba I, Massion P, Dubinett S, Elashoff D, Duan F, Spira A. Detection and Validation of Molecular Biomarkers for the Early Detection of Lung Cancer Among Military and Veteran Populations: The DECAMP Consortium. Chest. 2014; 146(4):590A. View Publication
Beane JE, Hijazi K, Steiling K, Liu G, Zhang S, Lam S, Lenburg ME. Abstract A27: Airway molecular alterations associated with premalignant lesion progression and lung cancer development. Cancer Prevention Research. 2014; 5(11 suppl):A27. View Publication
Park SJ, Walser T, Perdomo C, Wang T, Pagano PC, Liclican E, Krysan K, Larsen JE, Minna J, Lenburg ME, Spira A, Dubinett SM. Abstract B16: The effect of e-cigarette exposure on airway epithelial cell gene expression and transformation. Clinical Cancer Research. 2014; 20(2 suppl):B16. View Publication
Hijazi K, Malyszko B, Zhang X, Liu G. Alekseyev Y, Dumas YM, Hertsgaard L, Jenson J, Rhode C, Hatsukami D, Hecht SS, Brooks DR, O'Connors G, Lenburg M, Steiling K, Spira A. Abstract B07: Nasal epithelial gene expression profiles reflect dynamic biological response to smoking cessation. Cancer Prevention Research. 2014; 5(11 suppl):B07. View Publication

Christenson SA, Brandsma CA, Campbell JD, Knight DA, Pechkovsky DV, Hogg JC, Timens W, Postma DS, Lenburg M, Spira A. miR-638 regulates gene expression networks associated with emphysematous lung destruction. Genome Med. 2013; 5(12):114.View Related Profiles.

Spira, Avrum
Campbell, Joshua
Lenburg, Marc

PMID: 24380442; PMCID: PMC3971345; DOI: 10.1186/gm519;

Steiling K, Lenburg ME, Spira A. Personalized management of chronic obstructive pulmonary disease via transcriptomic profiling of the airway and lung. Ann Am Thorac Soc. 2013 Dec; 10 Suppl:S190-6.View Related Profiles.

Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 24313772; PMCID: PMC3960986; DOI: 10.1513/AnnalsATS.201306-190AW;

Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, Gomperts BN, Dubinett SM, Hayden P, Belinsky SA, Lenburg ME, Spira A. MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):18946-51.View Related Profiles.

Gower, Adam
Spira, Avrum
O'Hara, Carl
Garrison, Carly
Schembri, Frank
Campbell, Joshua
Lenburg, Marc

PMID: 24158479; PMCID: PMC3839685; DOI: 10.1073/pnas.1220319110;

van den Berge M, Steiling K, Timens W, Hiemstra PS, Sterk PJ, Heijink IH, Liu G, Alekseyev YO, Lenburg ME, Spira A, Postma DS. Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity. Thorax. 2014 Jan; 69(1):14-23.View Related Profiles.

Spira, Avrum
Liu, Gang
Steiling, Katrina
Lenburg, Marc
Alekseyev, Yuriy

PMID: 23925644; PMCID: PMC3888587; DOI: 10.1136/thoraxjnl-2012-202878;

Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O'Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med. 2013 May 1; 187(9):933-42.View Related Profiles.

Spira, Avrum
Dumont, Charles
Liu, Gang
O'Connor, George
Duclos, Grant
Campbell, Joshua
Steiling, Katrina
Lenburg, Marc
Sebastiani, Paola
Alekseyev, Yuriy

PMID: 23471465; PMCID: PMC3707363; DOI: 10.1164/rccm.201208-1449OC;

Zhang X, Lenburg ME, Spira A. Comparison of nasal epithelial smoking-induced gene expression on Affymetrix Exon 1.0 and Gene 1.0 ST arrays. ScientificWorldJournal. 2013; 2013:951416.View Related Profiles.

Spira, Avrum
Lenburg, Marc
Zhang, Xiaoling

PMID: 23476154; PMCID: PMC3588192; DOI: 10.1155/2013/951416;

Wang TW, Lan Q, Krystyna B, Rothman N, Florido R, Hu W, Steiling K, Liu G, Xiao J, Alekseyev Y, Xu J, Wei F, Hosgood HD, Reiss B, Downward G, Lenburg ME, Vermeulen R, Spira A. Abstract 112: Transcriptomic changes in the oral mucosal epithelium reflect the physiologic response to indoor burning of solid fuels. Cancer Research. 2013; 73(8 suppl):112. View Publication
Hijazi K, Malyszko B, Steiling K, Zhang X, Liu G, Alekseyev Y, Xiao J, Dumas M, Hertsgaard L, Jenson J, Rhode C, Isaksson R, Hatsukami D, Hecht S, Brooks D, Lenburg ME, Spira A. Abstract 4030: Nasal gene expression reflects the physiologic response to alternate tobacco products. Cancer Research. 2013; 73(8 suppl):4030. View Publication
Ooi AT, Gower AC, Zhang K, Vick J, Long-Sheng H, Fishbein M, Nagao B, Wallace WD, Elashoff D, Lenburg ME, Dubinett S, Spira A, Gomperts B. Abstract 1063: Examining early events in carcinogenesis by profiling premalignant lesions in the airways of patients with lung squamous cell carcinomas. Cancer Research. 2013; 73(8 suppl):1063. View Publication
Wolf DM, Yau C, Boudreau A, Esserman L, Van Veer LJ, Lenburg ME. Abstract 5221: Co-expression modules as hallmarks of breast cancer survival and response. Cancer Research. 2013; 73(8 suppl):5221. View Publication
Wang T, Campbell J, Kusko RL, Luo L, Tellez C, Liu G, Xiao J, Lenburg M, Belinsky S, Spira A. Abstract 1948: Shared and distinct microRNA-expression alterations in lung adenocarcinoma from smokers vs. nonsmokers. Cancer Research. 2013; 73(8 suppl):1948. View Publication

Beane J, Cheng L, Soldi R, Zhang X, Liu G, Anderlind C, Lenburg ME, Spira A, Bild AH. SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue. Cancer Res. 2012 Nov 15; 72(22):5702-11.View Related Profiles.

Spira, Avrum
Liu, Gang
Beane-Ebel, Jennifer
Lenburg, Marc

PMID: 22986747; PMCID: PMC4053174; DOI: 10.1158/0008-5472.CAN-12-1043;

Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma CA, Suzuki M, Gosselink JV, Liu G, Alekseyev YO, Xiao J, Zhang X, Hayashi S, Cooper JD, Timens W, Postma DS, Knight DA, Lenburg ME, Hogg JC, Spira A. A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. Genome Med. 2012; 4(8):67.View Related Profiles.

Spira, Avrum
Liu, Gang
Campbell, Joshua
Lenburg, Marc
Alekseyev, Yuriy

PMID: 22937864; PMCID: PMC4064320; DOI: 10.1186/gm368;

Piccolo SR, Sun Y, Campbell JD, Lenburg ME, Bild AH, Johnson WE. A single-sample microarray normalization method to facilitate personalized-medicine workflows. Genomics. 2012 Dec; 100(6):337-44.View Related Profiles.

Campbell, Joshua
Lenburg, Marc
Piccolo, Stephen
Johnson, William

PMID: 22959562; PMCID: PMC3508193; DOI: 10.1016/j.ygeno.2012.08.003;

Lee SY, Meier R, Furuta S, Lenburg ME, Kenny PA, Xu R, Bissell MJ. FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice. J Clin Invest. 2012 Sep 4; 122(9):3211-20. PMID: 22886303; PMCID: PMC3428077; DOI: 10.1172/JCI60498;

Horiuchi D, Kusdra L, Huskey NE, Chandriani S, Lenburg ME, Gonzalez-Angulo AM, Creasman KJ, Bazarov AV, Smyth JW, Davis SE, Yaswen P, Mills GB, Esserman LJ, Goga A. MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. J Exp Med. 2012 Apr 9; 209(4):679-96. PMID: 22430491; PMCID: PMC3328367; DOI: 10.1084/jem.20111512;

Hijazi K, Malyszko B, Zhang X, Liu G, Alekseyev Y, Dumas YM, Hertsgaard L, Jensen J, Rhode C, Hatsukami D, Brook DR, O'Connor G, Lenburg ME, Steiling KA, Spira A. American Thoracic Society 2012 International Conference. Nasal Epithelial Gene Expression Profiles Reflect The Host Response To Smoking Cessation. 2012. View Publication
Ma J, Steiling KA, Campbell JD, Singh A, Malhotra D, Elliot WM, Lenburg ME, Hogg JC, Spira A, Biswal S. American Thoracic Society 2012 International Conference. Global Gene And MicroRNA Expression Profiling Identifies MicroRNA-Gene Regulatory Networks In The Lung Tissue Of Smokers With COPD. 2012. View Publication
Mukhtar R, Wolf DM, Tandon VJ, Zhu J, Lenburg ME, Campbell M. P4-09-19: PCNA+ Tumor Associated Macrophages Are Associated with M1 and M2 Gene Expression, and Confer Poor Prognosis in the Absence of Anti-Tumor Immune Environment. Cancer Research. 2012; 71(24 suppl). View Publication
Lin Y, Zhang X, Sebastiani P, Beane J, Brooks D, O'Connor G, Lenburg ME, Spira A. American Thoracic Society 2012 International Conference. Upper Airway Gene Expression As A Biomarker Of Active And Secondhand Smoke Exposure. 2012. View Publication
Steiling KA, van den Berge M, Hijazi K, Florido R, Campbell JD, Liu G, Xiao J, Zhang X, Alekseyev Y, Sin D, Pare PD, Sebastiani P, Mcwilliams AM, Hiemstra PS, Sterk PJ, Timens W, Postma D, O'Connor G, Lam S, Spira A, Lenburg ME. American Thoracic Society 2012 International Conference. A Bronchial Airway Gene Expression Signature Of COPD That Is Reflective Of Lung Tissue Disease Processes And Is Reversible With Inhaled Steroids. 2012. View Publication
Brothers JF, Kusko RL, Liu G, Luo L, Juan-Guardela B, Tedrow J, Alekseyev Y, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba FC, Sebastiani P, Lenburg ME, Kaminski N, Schwartz DA, Spira A, Beane J. American Thoracic Society 2012 International Conference. Identification Of Lung Disease-Associated Novel Transcripts And Alternative Splicing By RNA-Sequencing. 2012. View Publication
Kusko RL, Brothers JF, Liu G, Luo L, Juan-Guardela B, Tedrow JR, Aleksyev Y, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba FC, Lenburg ME, Schwartz DA, Beane J, Kaminski N, Spira A. American Thoracic Society 2012 International Conference. Comprehensive Genomic Profiling Of The Lung Transcriptome In Emphysema And IPF Using RNA-Seq. 2012. View Publication
Brothers JF, Kusko RL, Liu G, Luo L, Juan-Guardela B, Tedrow J, Aleksyev Y, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba FC, Sebastiani P, Lenburg ME, Kaminski N, Schwartz DA, Spira A, Beane J . Moving beyond gene expression: identification of lung-disease-associated novel transcripts and alternative splicing by RNA sequencing. BMC proceedings. 2012; 6(6). View Publication
Campbell JD, Luo L, Liu G, Xiao J, Gerrein J, Juan-Guardela B, Tedrow J, Aleksyev YO, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba FC, Schwartz DA, Kaminski N, Lenburg ME, Beane J, Spira A. Characterizing The Small RNA Transcriptome Associated With COPD And ILD Using Next Generation Sequencing. BMC proceedings. 2012; 6(6). View Publication
Kusko RL, Brother JF, Liu G, Luo L, Juan-Guardela B, Tedrow J, Aleksyev Y, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba FC, Lenburg ME, Schwartz DA, Beane J, Kaminski N, Spira A. Comprehensive genomic profiling of the lung transcriptome in emphysema and idiopathic pulmonary fibrosis using RNA-Seq. BMC proceedings. 2012; 6(6). View Publication
Whitney D, Luo J, Porta Smith K, Lenburg ME, Brody J, Ernst A, Vachani A, Ferguson JS, Silvestri G, Spira A. Bronchial Airway Gene-Expression Testing Improves the Diagnostic Yield of Bronchoscopy for Lung Cancer: Results of the AEGIS Trial. Chest. 2012; 142:1025A. View Publication
Wang TW, Campbell JD, Luo L, Liu G, Xiao J, Lenburg ME, Belinsky SA, Spira A. Deep sequencing of the microRNA transcriptome in current, former, and never smokers with lung adenocarcinoma. BMC proceedings. 2012; 6(6). View Publication
Campbell JD, Luo L, Xiao J, Liu G, Aleksyev Y, Elashoff D, Dubinett SM, Lenburg ME, Spira A. Abstract 3154: Sequencing of the small RNA transcriptome in cytologically normal bronchial airway epithelium of smokers with and without lung cancer. Cancer Research. 2012; 72(8 suppl):3154. View Publication
Beane JE, Hijazi K, Liu G, Zhang X, Xiao J, Lam S, Lenburg ME, Spira A. Abstract 1607: Airway gene expression alterations associated with lung cancer chemoprevention using green tea extract. Cancer Research. 2012; 72(8 suppl):1607. View Publication
van den Berge M, Steiling KA, Timens W, Hiemstra PS, Sterk PJ, Liu G, Alexejev Y, Lenburg M, Spira A, Postma D. American Thoracic Society 2012 International Conference. Airway Gene Expression Is Dynamic With Inhaled Corticosteroid Treatment And Reflects Clinical Response In Patients With COPD. 2012. View Publication
Dumont C, Steiling KA, O'Connor G, Zhang X, Liu G, Xiao J, Alekseyev Y, Campbell J, Sin D, Lam S, Coxson HO, Spira A, Lenburg ME. American Thoracic Society 2012 International Conference. Airway Gene Expression Is Associated With The Radiographic Extent Of Emphysema In COPD. 2012. View Publication
Christenson SA, Brandsma CA, Hogg JC, Timens W, Postma D, Lenburg ME, Spira A. American Thoracic Society 2012 International Conference. MiR-638 Regulates Gene Expression Changes In Human Lung Fibroblasts. 2012. View Publication

Esserman LJ, Berry DA, Cheang MC, Yau C, Perou CM, Carey L, DeMichele A, Gray JW, Conway-Dorsey K, Lenburg ME, Buxton MB, Davis SE, van't Veer LJ, Hudis C, Chin K, Wolf D, Krontiras H, Montgomery L, Tripathy D, Lehman C, Liu MC, Olopade OI, Rugo HS, Carpenter JT, Livasy C, Dressler L, Chhieng D, Singh B, Mies C, Rabban J, Chen YY, Giri D, Au A, Hylton N. Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657). Breast Cancer Res Treat. 2012 Apr; 132(3):1049-62. PMID: 22198468; PMCID: PMC3332388; DOI: 10.1007/s10549-011-1895-2;

Gower AC, Spira A, Lenburg ME. Discovering biological connections between experimental conditions based on common patterns of differential gene expression. BMC Bioinformatics. 2011; 12:381.View Related Profiles.

Gower, Adam
Spira, Avrum
Lenburg, Marc

PMID: 21951600; PMCID: PMC3203354; DOI: 10.1186/1471-2105-12-381;

Beane J, Vick J, Schembri F, Anderlind C, Gower A, Campbell J, Luo L, Zhang XH, Xiao J, Alekseyev YO, Wang S, Levy S, Massion PP, Lenburg M, Spira A. Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq. Cancer Prev Res (Phila). 2011 Jun; 4(6):803-17.View Related Profiles.

Gower, Adam
Spira, Avrum
Schembri, Frank
Beane-Ebel, Jennifer
Campbell, Joshua
Luo, Lingqi
Lenburg, Marc
Alekseyev, Yuriy

PMID: 21636547; PMCID: PMC3694393; DOI: 10.1158/1940-6207.CAPR-11-0212;

Gower AC, Steiling K, Brothers JF, Lenburg ME, Spira A. Transcriptomic studies of the airway field of injury associated with smoking-related lung disease. Proc Am Thorac Soc. 2011 May; 8(2):173-9.View Related Profiles.

Gower, Adam
Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 21543797; PMCID: PMC3159071; DOI: 10.1513/pats.201011-066MS;

Campbell JD, Spira A, Lenburg ME. Applying gene expression microarrays to pulmonary disease. Respirology. 2011 Apr; 16(3):407-18.View Related Profiles.

Spira, Avrum
Campbell, Joshua
Lenburg, Marc

PMID: 21299687; DOI: 10.1111/j.1440-1843.2011.01942.x;

Brothers JF, Kusko RL, Luo L, Liu G, Juan-Guardela B, Tedrow J, Alekseyev Y, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba FC, Sebastiani P, Lenburg ME, Kaminski N, Schwartz DA, Spira A, Beane J. American Thoracic Society 2011 International Conference. Identifying Novel Transcripts And Alternative Splicing Associated With The ILD And COPD Lung Transcriptome Using MRNA-Seq. 2011. View Publication
Kusko RL, Beane J, Brothers JF, Liu G, Luo L, Juan-Guardela B, Tedrow J, Aleksyev Y, Yang IV, Correll M, Geraci M, Quackenbush J, Sciurba FC, Lenburg ME, Schwartz DA. Kaminski N, Spira A. American Thoracic Society 2011 International Conference. Characterizing The Lung Disease Transcriptome With Next Generation Rna-Sequencing. 2011. View Publication
Gibb WJ, Collisson E, Korkola J, Heiser LM, Sadanandam A, Kuo WL, Hu Z, Mao JH, Wang N, Bayani N, Billig J, Ziyad S, Lewis S, Feiler H, Jakkula L, Wolf DM, Lenburg M, Spellman PT, Gray JW. Abstract 1979: Algebraic factorization of gene expression profiles reveals subtype-specific drug sensitivities among 54 breast cancer cell lines. Cancer Research. 2011; 70(8 suppl):1979. View Publication
Ooi AT, Mah VH, Nickerson DW, Gilbert J, Ha VL, Hegab AE, Horvath S, Alavi M, Maresh EL, Chia D, Gower AC, Lenburg LE, Spira A, Walser T, Wallace WD, Dubinett SM, Goodglick L, Gomperts B. Abstract 4299: Poor prognosis in smokers with non-small cell lung cancer correlates with the presence of a reparative progenitor cell population. Cancer Research. 2011; 70(8 suppl):4299. View Publication
Goga A, Horiuchi D, Kusdra L, Chandriani S, Lenburg ME, Gonzalez-Angulo AM, Huskey NE, Creasman KJ, Davis SE, Mills GB, Esserman LJ. Synthetic-Lethality of Triple-Negative Breast Cancers Via the MYC Oncogene Pathway. Cancer Research. 2011; 70(24 suppl). View Publication
Steiling K, Ceron D, Campbell J, Xiao J, Zhang X, Liu G, Alekseyev Y, Mcwilliams AM, Hogg JC, Sebastiani P, O'Connor GT, Sin D, Coxson HO, Lam S, Lenburg ME, Spira A. American Thoracic Society 2011 International Conference. Airway Epithelial Gene Expression Patterns Associated With COPD Describe Potential Molecular Phenotypes Of Disease. 2011. View Publication
Suzuki M, Zeskind JE, McDonough JE, Gosselink JV, Elliott WM, Hayashi S, Cooper JD, Lenburg ME, Spira A, Hogg JC. American Thoracic Society 2011 International Conference. Macrophage Polarization During Centrilobular Emphysematous Destruction In COPD. 2011. View Publication
Beane J, Vick J, Gindin Y, Anderlind C, Schembri F, Liu G, Wang S, Levy S, Massion P, Lenburg M, Spira A. American Thoracic Society 2011 International Conference. RNA-seq Identifies Novel Changes In The Airway Transcriptome Associated With Smoking And Lung Cancer. 2011. View Publication
Steiling K, Van Den Berge M, Sebastiani P, Connor GO, Zhang X, Liu G, Xiao J, Alekseyev Y, Campbell J, Coxson HO, Hogg JC, Mcwilliams AM, Timens W, Hiemstra PS, Sterk PJ, Sin D, Postma D, Lam S, Lenburg ME, Spira A. Airway Gene Expression as a Molecular Phenotype of COPD. Proc Am Thorac Soc. 2011; 8.
DeMichele A, Yau C, Zhu J, Wuhfkuhle J, Lenburg ME, Buxton M, Davis S, Mies C, Livasy C, Chin K, Gray JW, Carey LA, Esserman L, Petricoin E. Comparison of Community and Central Her2 Assessment on Outcome of Neoadjuvant Chemotherapy in the I-SPY Trial. Cancer Research. 2011; 71(24 suppl). View Publication
Anderlind C, Brothers JF, Lenburg M, Brody J, Spira A. American Journal of Respiratory and Critical Care Medicine. Gene Expression Profiles In Nasal Epithelium Differ Between Smokers With And Without Lung Cancer. 2011; 183:A1050. View Publication
Wolf DM, Lenburg ME, Yau C, Boudreau A, Esserman L, Hylton N, van Veer LJ. Abstract LB-311: Combinatorial logic over breast cancer control modules predicts survival and chemotherapy response of ISPY1 breast cancer patients (CALGB 150007/150012; ACRIN 6657). Cancer Research. 2011; 71(8 suppl). View Publication
Lin Y, Zhang X, O'Connor GT, Brooks DR, Zhang S, Alekseyev Y, Sebastiani P, Lenburg M, Spira A. American Thoracic Society 2011 International Conference. Upper Airway Gene Expression As A Biomarker Of Environmental Tobacco Exposure. 2011. View Publication
Gerrein J, Perdomo C, Campbell JD, Vick J, Gower AC, Anderlind C, Schembri F, Spira A, Lenburg ME. Abstract 3989: Discovery of a novel airway microRNA associated with lung cancer using next generation sequencing. Cancer Research. 2011; 71(8 suppl):3989. View Publication
Beane J, Gerrein J, Vick J, Gindin Y, Anderlind C, Levy S, Massion P, Schembri F, Lenburg ME, Spira A. Abstract 1987: RNA-seq of the bronchial airway transcriptome identifies novel gene and microRNA expression changes associated with smoking and lung cancer. Cancer Research. 2011; 70(8 suppl):1987. View Publication

Boelens MC, Gustafson AM, Postma DS, Kok K, van der Vries G, van der Vlies P, Spira A, Lenburg ME, Geerlings M, Sietsma H, Timens W, van den Berg A, Groen HJ. A chronic obstructive pulmonary disease related signature in squamous cell lung cancer. Lung Cancer. 2011 May; 72(2):177-83.View Related Profiles.

Spira, Avrum
Lenburg, Marc

PMID: 20832896; DOI: 10.1016/j.lungcan.2010.08.014;

Ooi AT, Mah V, Nickerson DW, Gilbert JL, Ha VL, Hegab AE, Horvath S, Alavi M, Maresh EL, Chia D, Gower AC, Lenburg ME, Spira A, Solis LM, Wistuba II, Walser TC, Wallace WD, Dubinett SM, Goodglick L, Gomperts BN. Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer. Cancer Res. 2010 Aug 15; 70(16):6639-48.View Related Profiles.

Gower, Adam
Spira, Avrum
Lenburg, Marc

PMID: 20710044; PMCID: PMC2924777; DOI: 10.1158/0008-5472.CAN-10-0455;

Panchenko MP, Siddiquee Z, Dombkowski DM, Alekseyev YO, Lenburg ME, Walker JD, Macgillivray TE, Preffer FI, Stone JR. Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasia. Am J Pathol. 2010 Sep; 177(3):1562-72.View Related Profiles.

Lenburg, Marc
Alekseyev, Yuriy

PMID: 20696773; PMCID: PMC2928985; DOI: 10.2353/ajpath.2010.100327;

Blick T, Hugo H, Widodo E, Waltham M, Pinto C, Mani SA, Weinberg RA, Neve RM, Lenburg ME, Thompson EW. Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia. 2010 Jun; 15(2):235-52. PMID: 20521089; DOI: 10.1007/s10911-010-9175-z;

Gustafson AM, Soldi R, Anderlind C, Scholand MB, Qian J, Zhang X, Cooper K, Walker D, McWilliams A, Liu G, Szabo E, Brody J, Massion PP, Lenburg ME, Lam S, Bild AH, Spira A. Airway PI3K pathway activation is an early and reversible event in lung cancer development. Sci Transl Med. 2010 Apr 7; 2(26):26ra25.View Related Profiles.

Spira, Avrum
Anderlind, Christina
Liu, Gang
Brody, Jerome
Qian, Jun
Lenburg, Marc

PMID: 20375364; PMCID: PMC3694402; DOI: 10.1126/scitranslmed.3000251;

Salisbury Palomares KT, Gerstenfeld LC, Wigner NA, Lenburg ME, Einhorn TA, Morgan EF. Transcriptional profiling and biochemical analysis of mechanically induced cartilaginous tissues in a rat model. Arthritis Rheum. 2010 Apr; 62(4):1108-18.View Related Profiles.

Morgan, Elise
Gerstenfeld, Louis
Lenburg, Marc
Einhorn, Thomas

PMID: 20131271; PMCID: PMC2929815; DOI: 10.1002/art.27343;

Hu Z, Huang G, Sadanandam A, Gu S, Lenburg ME, Pai M, Bayani N, Blakely EA, Gray JW, Mao JH. The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer. Breast Cancer Res. 2010; 12(2):R18. PMID: 20211017; PMCID: PMC2879562; DOI: 10.1186/bcr2487;

Cartwright MJ, Schlauch K, Lenburg ME, Tchkonia T, Pirtskhalava T, Cartwright A, Thomou T, Kirkland JL. Aging, depot origin, and preadipocyte gene expression. J Gerontol A Biol Sci Med Sci. 2010 Mar; 65(3):242-51. PMID: 20106964; PMCID: PMC2904595; DOI: 10.1093/gerona/glp213;

Papageorgis P, Lambert AW, Ozturk S, Gao F, Pan H, Manne U, Alekseyev YO, Thiagalingam A, Abdolmaleky HM, Lenburg M, Thiagalingam S. Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res. 2010 Feb 1; 70(3):968-78.View Related Profiles.

Lambert, Arthur
Lenburg, Marc
Thiagalingam, Sam
Alekseyev, Yuriy

PMID: 20086175; PMCID: PMC2946209; DOI: 10.1158/0008-5472.CAN-09-1872;

Wulfkuhle JD, Lenburg ME, Pierobon M, Illi J, Zhu J, DeMichele A, Espina VA, Liotta LA, Esserman L, Petricoin E. Protein signal pathway mapping of human breast cancer from I-SPY: Correlations with response and genomic subtyping. Journal of Clinical Oncology. 2010; 28(15 suppl):10512. View Publication
Brothers JF, Neumann S, Campbell JD, Zeskind J, Lenburg ME, Sebastiani P, McDonough JE, Pare PD, He J, Hogg JC, Kobor MS, Spira A. American Thoracic Society 2010 International Conference. The Role Of Promoter Methylation In Regulating The Expression Of Genes Associated With COPD Progression. 2010. View Publication
Gerrein J, Beane J, Vick J, Gindin Y, Anderlind C, Levy S, Massion P, Schembri FM, Lenburg ME, Spira A. American Thoracic Society 2010 International Conference. Next Generation Sequencing Of The Bronchial Airway Transcriptome Identifies Novel Gene And MicroRNA Changes Associated With Smoking And Lung-cancer. 2010. View Publication
Steiling K, Ma J, Campbell JD. Malhotra D, Lenburg ME, Singh A, Elliott WM, Hogg JC, Spira A, Biswal S. American Thoracic Society 2010 International Conference. Alterations In Gene And MicroRNA Expression In The Lung Tissue Of Smokers With Chronic Obstructive Pulmonary Disease. 2010. View Publication

Steiling K, Lenburg ME, Spira A. Airway gene expression in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec; 6(8):697-700.View Related Profiles.

Spira, Avrum
Steiling, Katrina
Lenburg, Marc

PMID: 20008878; PMCID: PMC2797071; DOI: 10.1513/pats.200907-076DP;

Zhang X, Sebastiani P, Liu G, Schembri F, Zhang X, Dumas YM, Langer EM, Alekseyev Y, O'Connor GT, Brooks DR, Lenburg ME, Spira A. Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium. Physiol Genomics. 2010 Mar 3; 41(1):1-8.View Related Profiles.

Spira, Avrum
Brooks, Daniel
Schembri, Frank
Liu, Gang
O'Connor, George
Lenburg, Marc
Sebastiani, Paola
Zhang, Xiaoling
Alekseyev, Yuriy
Dumas, Yves-Martine

PMID: 19952278; PMCID: PMC2841495; DOI: 10.1152/physiolgenomics.00167.2009;

Steiling K, Kadar AY, Bergerat A, Flanigon J, Sridhar S, Shah V, Ahmad QR, Brody JS, Lenburg ME, Steffen M, Spira A. Comparison of proteomic and transcriptomic profiles in the bronchial airway epithelium of current and never smokers. PLoS One. 2009; 4(4):e5043.View Related Profiles.

Bergerat, Agnes M
Spira, Avrum
Brody, Jerome
Steiling, Katrina
Lenburg, Marc
Steffen, Martin

PMID: 19357784; PMCID: PMC2664466; DOI: 10.1371/journal.pone.0005043;

Zhou J, Huang W, Tao R, Ibaragi S, Lan F, Ido Y, Wu X, Alekseyev YO, Lenburg ME, Hu GF, Luo Z. Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells. Oncogene. 2009 May 7; 28(18):1993-2002.View Related Profiles.

Lenburg, Marc
Ido, Yasuo
Alekseyev, Yuriy
Luo, Zhijun

PMID: 19347029; PMCID: PMC2679420; DOI: 10.1038/onc.2009.63;

Zhu J, Sanborn JZ, Benz S, Szeto C, Hsu F, Kuhn RM, Karolchik D, Archie J, Lenburg ME, Esserman LJ, Kent WJ, Haussler D, Wang T. The UCSC Cancer Genomics Browser. Nat Methods. 2009 Apr; 6(4):239-40. PMID: 19333237; PMCID: PMC5027375; DOI: 10.1038/nmeth0409-239;

Schembri F, Sridhar S, Perdomo C, Gustafson AM, Zhang X, Ergun A, Lu J, Liu G, Zhang X, Bowers J, Vaziri C, Ott K, Sensinger K, Collins JJ, Brody JS, Getts R, Lenburg ME, Spira A. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2319-24.View Related Profiles.

Spira, Avrum
Vaziri, Cyrus
Schembri, Frank
Liu, Gang
Brody, Jerome
Lu, Jining
Lenburg, Marc
Zhang, Xiaoling

PMID: 19168627; PMCID: PMC2650144; DOI: 10.1073/pnas.0806383106;

Hu Z, Mao J, Huang G, Kuo W, Lenburg ME, Ziyad S, Korkola J, Bayani N, Wang N, Weber B, Gu S, Wooster R, Gray JW. A Systems Analysis of Mitotic Apparatus Inhibitors Defines a Response Network for Breast Cancer. Cancer Research. 2009; 69(24 suppl):2020. View Publication
Blick T, Widodo E, Hugo HJ, Lenburg ME, Neve RM, Waltham M, Thompson E. Large scale analyses of human breast cancer cell lines provides leads for analysis of EMT in clinical breast cancer. Clinical and Experimental Metastasis. 2009; 26(7):934.
Christenson SA, Schembri FM, Sridhar S, Campbell J, Zhang X, Lenburg ME, Spira A. American Thoracic Society 2009 International Conference. Impact of Smoking on miRNA Expression in Buccal and Nasal Epithelium. 2009. View Publication
Beane JE, Gustafson A, Zhang S, Liu G, Lenburg ME, Bild A, Spira A. American Thoracic Society 2009 International Conference. Activation of Signaling Pathways in the Airway Epithelium of Never and Current Smokers. 2009. View Publication
Anderlind C, Brothers JF, Daly BDT, Lenburg ME, Brody JS, Hinds A, Ebright MI, Fernando HC, Reardon C, O'Hara CJ, Spira A, Kathuria H. American Thoracic Society 2009 International Conference. Detection of Gene Expression Signatures in Tumor Free Lymph Node Tissue Predicts Prognosis in Non-Small Cell Lung Cancer (NSCLC). 2009. View Publication

Liu P, Slater DM, Lenburg M, Nevis K, Cook JG, Vaziri C. Replication licensing promotes cyclin D1 expression and G1 progression in untransformed human cells. Cell Cycle. 2009 Jan 1; 8(1):125-36.View Related Profiles.

Vaziri, Cyrus
Lenburg, Marc

PMID: 19106611; PMCID: PMC3032797; DOI: 10.4161/cc.8.1.7528;

Beane J, Spira A, Lenburg ME. Clinical impact of high-throughput gene expression studies in lung cancer. J Thorac Oncol. 2009 Jan; 4(1):109-18.View Related Profiles.

Spira, Avrum
Beane-Ebel, Jennifer
Lenburg, Marc

PMID: 19096318; PMCID: PMC2731413; DOI: 10.1097/JTO.0b013e31819151f8;

Merritt WM, Lin YG, Han LY, Kamat AA, Spannuth WA, Schmandt R, Urbauer D, Pennacchio LA, Cheng JF, Nick AM, Deavers MT, Mourad-Zeidan A, Wang H, Mueller P, Lenburg ME, Gray JW, Mok S, Birrer MJ, Lopez-Berestein G, Coleman RL, Bar-Eli M, Sood AK. Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med. 2008 Dec 18; 359(25):2641-50. PMID: 19092150; PMCID: PMC2710981; DOI: 10.1056/NEJMoa0803785;

Zeskind JE, Lenburg ME, Spira A. Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management. Proc Am Thorac Soc. 2008 Dec 1; 5(8):834-41.View Related Profiles.

Spira, Avrum
Lenburg, Marc

PMID: 19017738; PMCID: PMC2645236; DOI: 10.1513/pats.200807-074TH;

Sridhar S, Schembri F, Zeskind J, Shah V, Gustafson AM, Steiling K, Liu G, Dumas YM, Zhang X, Brody JS, Lenburg ME, Spira A. Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium. BMC Genomics. 2008; 9:259.View Related Profiles.

Spira, Avrum
Schembri, Frank
Liu, Gang
Brody, Jerome
Steiling, Katrina
Lenburg, Marc
Dumas, Yves-Martine

PMID: 18513428; PMCID: PMC2435556; DOI: 10.1186/1471-2164-9-259;

Blick T, Widodo E, Hugo H, Waltham M, Lenburg ME, Neve RM, Thompson EW. Epithelial mesenchymal transition traits in human breast cancer cell lines. Clin Exp Metastasis. 2008; 25(6):629-42. PMID: 18461285; DOI: 10.1007/s10585-008-9170-6;

Tripathi A, King C, de la Morenas A, Perry VK, Burke B, Antoine GA, Hirsch EF, Kavanah M, Mendez J, Stone M, Gerry NP, Lenburg ME, Rosenberg CL. Gene expression abnormalities in histologically normal breast epithelium of breast cancer patients. Int J Cancer. 2008 Apr 1; 122(7):1557-66.View Related Profiles.

Antoine, Gregory
Mendez, Jane
Lenburg, Marc
Kavanah, Maureen

PMID: 18058819

Beane J, Sebastiani P, Whitfield TH, Steiling K, Dumas YM, Lenburg ME, Spira A. A prediction model for lung cancer diagnosis that integrates genomic and clinical features. Cancer Prev Res (Phila). 2008 Jun; 1(1):56-64.View Related Profiles.

Spira, Avrum
Beane-Ebel, Jennifer
Steiling, Katrina
Lenburg, Marc
Sebastiani, Paola
Dumas, Yves-Martine

PMID: 19138936; PMCID: PMC4167688; DOI: 10.1158/1940-6207.CAPR-08-0011;

Merritt WM, Lin Y, Han LY, Kamat AA, Spannuth WA, Schmandt R, Urbauer D, Pennacchio LA, Cheng JF, Zeidan A, Wang H, Mueller P, Lenburg ME, Gray JW, Mok SC, Birrer MJ, Lopez-Berestein G, Coleman RL, Bar-Eli M, Sood AK. Decreased expression of RNA interference machinery, Dicer and Drosha, is associated with poor outcome in ovarian cancer patients. New England Journal of Medicine. 2008.
Yau C, Moore D, Fan E, Chu B, Lenburg ME, Snisky J, Waldman F, Esserman L, Park JW, Benz C. Defining new multi-gene classifiers and prognostic indicators for hormone receptor and triple negative breast cancers. Cancer biomarkers: section A of Disease markers. 2008; 4(3):140-141.

Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI. Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. Gene Expr Patterns. 2008 Jan; 8(2):124-39.View Related Profiles.

Spira, Avrum
Beane-Ebel, Jennifer
Lu, Jining
Lenburg, Marc
Ramirez, Maria

PMID: 18023262; PMCID: PMC2440337; DOI: 10.1016/j.modgep.2007.09.003;

Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, Gilman S, Dumas YM, Calner P, Sebastiani P, Sridhar S, Beamis J, Lamb C, Anderson T, Gerry N, Keane J, Lenburg ME, Brody JS. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nat Med. 2007 Mar; 13(3):361-6.View Related Profiles.

Spira, Avrum
Schembri, Frank
Liu, Gang
Beane-Ebel, Jennifer
Brody, Jerome
Steiling, Katrina
Lenburg, Marc
Sebastiani, Paola
Dumas, Yves-Martine

PMID: 17334370

Herbert A, Lenburg ME, Ulrich D, Gerry NP, Schlauch K, Christman MF. Open-access database of candidate associations from a genome-wide SNP scan of the Framingham Heart Study. Nat Genet. 2007 Feb; 39(2):135-6.View Related Profiles.

Herbert, Alan
Lenburg, Marc

PMID: 17262019

Beane J, Sebastiani P, Liu G, Brody JS, Lenburg ME, Spira A. Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression. Genome Biol. 2007; 8(9):R201.View Related Profiles.

Spira, Avrum
Liu, Gang
Beane-Ebel, Jennifer
Brody, Jerome
Lenburg, Marc
Sebastiani, Paola

PMID: 17894889; PMCID: PMC2375039; DOI: 10.1186/gb-2007-8-9-r201;

Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, Gilman S, Dumas YM, Calner P, Sebastiani P, Sridhar S, Beamis J, Lamb C, Anderson T, Gerry N, Keane J, Lenburg ME, Brody JS. Airway gene expression in smokers as a novel biomarker for lung cancer. Cancer Investigation. 2007; 25:51-52.
Kirkland J, Cartwright M, Tchkonia T, Lenburg ME, Schlauch K, Pirtskhalava T, Cartwright A, Lopez M, Frampton G. International Journal of Obesity. Aging, fat depot origin, and preadipocyte expression profiles: setting the stage for fat tissue dysfunction. 2007.

Zhang X, Liu G, Lenburg ME, Spira A. Comparison of smoking-induced gene expression on Affymetrix Exon and 3'-based expression arrays. Genome Inform. 2007; 18:247-57.View Related Profiles.

Spira, Avrum
Liu, Gang
Lenburg, Marc
Zhang, Xiaoling

PMID: 18546492

Lenburg ME, Sinha A, Faller DV, Denis GV. Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis. J Biol Chem. 2007 Feb 16; 282(7):4803-11.View Related Profiles.

Faller, Douglas
Denis, Gerald
Lenburg, Marc

PMID: 17166848; PMCID: PMC2819333; DOI: 10.1074/jbc.M605870200;

Tchkonia T, Lenburg M, Thomou T, Giorgadze N, Frampton G, Pirtskhalava T, Cartwright A, Cartwright M, Flanagan J, Karagiannides I, Gerry N, Forse RA, Tchoukalova Y, Jensen MD, Pothoulakis C, Kirkland JL. Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E298-307. PMID: 16985259

Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, Wichmann HE, Meitinger T, Hunter D, Hu FB, Colditz G, Hinney A, Hebebrand J, Koberwitz K, Zhu X, Cooper R, Ardlie K, Lyon H, Hirschhorn JN, Laird NM, Lenburg ME, Lange C, Christman MF. A common genetic variant is associated with adult and childhood obesity. Science. 2006 Apr 14; 312(5771):279-83.View Related Profiles.

Herbert, Alan
Lenburg, Marc

PMID: 16614226

Kanefsky J, Lenburg M, Hai CM. Cholinergic receptor and cyclic stretch-mediated inflammatory gene expression in intact ASM. Am J Respir Cell Mol Biol. 2006 Apr; 34(4):417-25. PMID: 16339998; PMCID: PMC2644203; DOI: 10.1165/rcmb.2005-0326OC;

Klings ES, Safaya S, Adewoye AH, Odhiambo A, Frampton G, Lenburg M, Gerry N, Sebastiani P, Steinberg MH, Farber HW. Differential gene expression in pulmonary artery endothelial cells exposed to sickle cell plasma. Physiol Genomics. 2005 May 11; 21(3):293-8.View Related Profiles.

Klings, Elizabeth
Farber, Harrison
Lenburg, Marc
Steinberg, Martin
Sebastiani, Paola

PMID: 15741505

King C, Guo N, Frampton GM, Gerry NP, Lenburg ME, Rosenberg CL. Reliability and reproducibility of gene expression measurements using amplified RNA from laser-microdissected primary breast tissue with oligonucleotide arrays. J Mol Diagn. 2005 Feb; 7(1):57-64. PMID: 15681475; PMCID: PMC1867505; DOI: 10.1016/S1525-1578(10)60009-8;

Kirkland J, Tchkonia T, Lenburg ME, Prabhu V, Giorgadze N, Pirtskhalava T, Thomou T, Forse A, Pothoulakis C, Becker K. Obesity research. Are different fat depots separate mini-organs?. 2005.

Carson JP, Zhang N, Frampton GM, Gerry NP, Lenburg ME, Christman MF. Pharmacogenomic identification of targets for adjuvant therapy with the topoisomerase poison camptothecin. Cancer Res. 2004 Mar 15; 64(6):2096-104. PMID: 15026349

Lenburg ME, Liou LS, Gerry NP, Frampton GM, Cohen HT, Christman MF. Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data. BMC Cancer. 2003 Nov 27; 3:31.View Related Profiles.

Cohen, Herbert
Lenburg, Marc

PMID: 14641932; PMCID: PMC317310

Lenburg ME, O'Shea EK. Genetic evidence for a morphogenetic function of the Saccharomyces cerevisiae Pho85 cyclin-dependent kinase. Genetics. 2001 Jan; 157(1):39-51. PMID: 11139490; PMCID: PMC1283135

Lenburg ME, O'Shea EK. Signaling phosphate starvation. Trends Biochem Sci. 1996 Oct; 21(10):383-7. PMID: 8918192

Anderson SJ, Lenburg M, Landau NR, Garcia JV. The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef. J Virol. 1994 May; 68(5):3092-101. PMID: 8151774; PMCID: PMC236799

Aiken C, Konner J, Landau NR, Lenburg ME, Trono D. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell. 1994 Mar 11; 76(5):853-64. PMID: 8124721

Lenburg ME, Landau NR. Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4. J Virol. 1993 Dec; 67(12):7238-45. PMID: 8230446; PMCID: PMC238186

Snyder RW, Lenburg ME, Seebaum AT, Grabel LB. Disruption of the cytoskeleton-extracellular matrix linkage promotes the accumulation of plasminogen activators in F9 derived parietal endoderm. Differentiation. 1992 Aug; 50(3):153-62. PMID: 1330791

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 212 publications over 29 distinct years, with a maximum of 22 publications in 2012

Bar chart showing 212 publications over 29 distinct years, with a maximum of 22 publications in 2012

Year	Publications
1992	1
1993	1
1994	2
1996	1
2001	1
2003	1
2004	1
2005	4
2006	3
2007	7
2008	8
2009	13
2010	13
2011	20
2012	22
2013	11
2014	16
2015	16
2016	15
2017	14
2018	3
2019	5
2020	5
2021	7
2022	5
2023	7
2024	2
2025	2
2026	6