Marc Lenburg, PhD
Professor
Boston University School of Medicine
Dept of Medicine
Computational Biomedicine

PhD, University of California, San Francisco



Expertise in computational approaches to leverage genome-wide datasets (especially genome-wide gene-expression) for clinical and biological insight. Interests include developing and applying these tools for translational research.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Professor
Boston University School of Medicine
Pathology & Laboratory Medicine


Member
Boston University
Bioinformatics Graduate Program




Molecular and Imaging biomarkers for early lung cancer detection in the setting of Indeterminate Pulmonary Nodules
09/23/2016 - 08/31/2021 (Multi-PI)
PI: Marc Lenburg, PhD
NIH/National Cancer Institute
5R01CA210360-02

The Boston University-UCLA Lung Cancer Biomarker Development Lab
09/20/2016 - 08/31/2021 (Co-PI)
PI: Avrum Spira, MD
NIH/National Cancer Institute
5U01CA214182-02

Study BET inhibitors in COPD
12/18/2017 - 12/17/2018 (PI)
AstraZeneca AB

Integrative Omics to Discover Molecular Determinants of COPD
06/01/2016 - 05/31/2018 (Multi-PI)
PI: Marc Lenburg, PhD
NIH/National Heart, Lung, and Blood Institute
4R01HL118542-04

Molecular biomarkers of airway and lung linking COPD and Lung Cancer
09/15/2011 - 07/31/2016 (Co-PI)
PI: Avrum Spira, MD
NIH/National Cancer Institute
5R01CA164783-04

Integrative Omics to Discover Molecular Determinants of COPD
08/15/2013 - 05/31/2016 (Multi-PI)
PI: Marc Lenburg, PhD
NIH/National Heart, Lung, and Blood Institute
5R01HL118542-03

Validation of a Genomic Biomarker of Responses to Environmental Tobacco Smoke
08/08/2011 - 06/30/2015 (Multi-PI)
PI: Marc Lenburg, PhD
NIH/National Institute of Environmental Health Sciences
5R01ES020425-02




Yr Title Project-Sub Proj Pubs
2017 Molecular and Imaging Biomarkers for Early Lung Cancer Detection in the Setting of Indeterminate Pulmonary Nodules 5R01CA210360-02
2017 The Boston University-UCLA Lung Cancer Biomarker Development Lab 5U01CA214182-02
2016 Molecular and Imaging Biomarkers for Early Lung Cancer Detection in the Setting of Indeterminate Pulmonary Nodules 1R01CA210360-01
2016 The Boston University-UCLA Lung Cancer Biomarker Development Lab 1U01CA214182-01
2016 Integrative Omics to Discover Molecular Determinants of COPD 4R01HL118542-04 1
2015 The UCLA - Boston University Lung Cancer Biomarker Development Laboratory 3U01CA152751-05S2 12
2014 Integrative Omics to Discover Molecular Determinants of COPD 5R01HL118542-02 1
2014 Molecular biomarkers of airway and lung linking COPD and Lung Cancer 5R01CA164783-04 10
2014 The UCLA - Boston University Lung Cancer Biomarker Development Laboratory 5U01CA152751-05 12
2013 Integrative Omics to Discover Molecular Determinants of COPD 1R01HL118542-01 1
Showing 10 of 26 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Billatos E, Faiz A, Gesthalter YO, LeClerc A, Alekseyev Y, Zhang X, Liu G, Ten Hacken NHT, Heijink I, Timens W, Brandsma CA, Postma DS, van den Berge M, Spira A, Lenburg ME. The Impact of Acute Exposure to Cigarette Smoke on Airway Gene Expression. Physiol Genomics. 2018 06 22.View Related Profiles. PMID: 29932825.
     
  2. Billatos E, Vick JL, Lenburg ME, Spira AE. The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection. Clin Cancer Res. 2018 Jul 01; 24(13):2984-2992.View Related Profiles. PMID: 29463557.
     
  3. Boudewijn IM, Faiz A, Steiling K, van der Wiel E, Telenga ED, Hoonhorst SJM, Ten Hacken NHT, Brandsma CA, Kerstjens HAM, Timens W, Heijink IH, Jonker MR, de Bruin HG, Sebastiaan Vroegop J, Pasma HR, Boersma WG, Wielders P, van den Elshout F, Mansour K, Spira A, Lenburg ME, Guryev V, Postma DS, van den Berge M. Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression. Respir Res. 2017 12 21; 18(1):213.View Related Profiles. PMID: 29268739.
     
  4. Ong J, Timens W, Rajendran V, Algra A, Spira A, Lenburg ME, Campbell JD, van den Berge M, Postma DS, van den Berg A, Kluiver J, Brandsma CA. Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts. PLoS One. 2017; 12(9):e0183815.View Related Profiles. PMID: 28910321.
     
  5. Pavel AB, Campbell JD, Liu G, Elashoff D, Dubinett S, Smith K, Whitney D, Lenburg ME, Spira A. Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection. Cancer Prev Res (Phila). 2017 Nov; 10(11):651-659.View Related Profiles. PMID: 28877936.
     
  6. Suzuki M, Sze MA, Campbell JD, Brothers JF, Lenburg ME, McDonough JE, Elliott WM, Cooper JD, Spira A, Hogg JC. The cellular and molecular determinants of emphysematous destruction in COPD. Sci Rep. 2017 Aug 25; 7(1):9562.View Related Profiles. PMID: 28842670.
     
  7. Shared Gene Expression Alterations in Nasal and Bronchial Epithelium for Lung Cancer Detection. J Natl Cancer Inst. 2017 Jul 01; 109(7). PMID: 28376173; DOI: 10.1093/jnci/djw327;.
     
  8. Beane J, Mazzilli SA, Tassinari AM, Liu G, Zhang X, Liu H, Buncio AD, Dhillon SS, Platero SJ, Lenburg ME, Reid ME, Lam S, Spira AE. Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression. Clin Cancer Res. 2017 Sep 01; 23(17):5091-5100.View Related Profiles. PMID: 28533227.
     
  9. Hu Z, Mao JH, Curtis C, Huang G, Gu S, Heiser L, Lenburg ME, Korkola JE, Bayani N, Samarajiwa S, Seoane JA, Dane MA, Esch A, Feiler HS, Wang NJ, Hardwicke MA, Laquerre S, Jackson J, Wood KW, Weber B, Spellman PT, Aparicio S, Wooster R, Caldas C, Gray JW. Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer. Breast Cancer Res. 2017 02 09; 19(1):17. PMID: 28183333; DOI: 10.1186/s13058-017-0809-6;.
     
  10. Vasilescu DM, Phillion AB, Tanabe N, Kinose D, Paige DF, Kantrowitz JJ, Liu G, Liu H, Fishbane N, Verleden SE, Vanaudenaerde BM, Lenburg M, Stevenson CS, Spira A, Cooper JD, Hackett TL, Hogg JC. Nondestructive cryomicro-CT imaging enables structural and molecular analysis of human lung tissue. J Appl Physiol (1985). 2017 Jan 01; 122(1):161-169.View Related Profiles. PMID: 27856720; DOI: 10.1152/japplphysiol.00838.2016;.
     
Showing 10 of 85 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 85 publications over 21 distinct years, with a maximum of 9 publications in 2010

YearPublications
19921
19931
19942
19961
20011
20031
20041
20053
20063
20075
20086
20098
20109
20115
20125
20136
20146
20156
20166
20177
20182
Contact for Mentoring:


75 E. Newton St Evans Building
Boston MA 02118
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