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Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, Lin H, Arking DE, Smith AV, Albert CM, Chaffin M, Tucker NR, Li M, Klarin D, Bihlmeyer NA, Low SK, Weeke PE, Müller-Nurasyid M, Smith JG, Brody JA, Niemeijer MN, Dörr M, Trompet S, Huffman J, Gustafsson S, Schurmann C, Kleber ME, Lyytikäinen LP, Seppälä I, Malik R, Horimoto ARVR, Perez M, Sinisalo J, Aeschbacher S, Thériault S, Yao J, Radmanesh F, Weiss S, Teumer A, Choi SH, Weng LC, Clauss S, Deo R, Rader DJ, Shah SH, Sun A, Hopewell JC, Debette S, Chauhan G, Yang Q, Worrall BB, Paré G, Kamatani Y, Hagemeijer YP, Verweij N, Siland JE, Kubo M, Smith JD, Van Wagoner DR, Bis JC, Perz S, Psaty BM, Ridker PM, Magnani JW, Harris TB, Launer LJ, Shoemaker MB, Padmanabhan S, Haessler J, Bartz TM, Waldenberger M, Lichtner P, Arendt M, Krieger JE, Kähönen M, Risch L, Mansur AJ, Peters A, Smith BH, Lind L, Scott SA, Lu Y, Bottinger EB, Hernesniemi J, Lindgren CM, Wong JA, Huang J, Eskola M, Morris AP, Ford I, Reiner AP, Delgado G, Chen LY, Chen YI, Sandhu RK, Li M, Boerwinkle E, Eisele L, Lannfelt L, Rost N, Anderson CD, Taylor KD, Campbell A, Magnusson PK, Porteous D, Hocking LJ, Vlachopoulou E, Pedersen NL, Nikus K, Orho-Melander M, Hamsten A, Heeringa J, Denny JC, Kriebel J, Darbar D, Newton-Cheh C, Shaffer C, Macfarlane PW, Heilmann-Heimbach S, Almgren P, Huang PL, Sotoodehnia N, Soliman EZ, Uitterlinden AG, Hofman A, Franco OH, Völker U, Jöckel KH, Sinner MF, Lin HJ, Guo X, Dichgans M, Ingelsson E, Kooperberg C, Melander O, Loos RJF, Laurikka J, Conen D, Rosand J, van der Harst P, Lokki ML, Kathiresan S, Pereira A, Jukema JW, Hayward C, Rotter JI, März W, Lehtimäki T, Stricker BH, Chung MK, Felix SB, Gudnason V, Alonso A, Roden DM, Kääb S, Chasman DI, Heckbert SR, Benjamin EJ, Tanaka T, Lunetta KL, Lubitz SA, Ellinor PT. Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat Genet. 2017 Jun; 49(6):946-952.View Related Profiles. PMID: 28416818; DOI: 10.1038/ng.3843;
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de Vries PS, Sabater-Lleal M, Chasman DI, Trompet S, Ahluwalia TS, Teumer A, Kleber ME, Chen MH, Wang JJ, Attia JR, Marioni RE, Steri M, Weng LC, Pool R, Grossmann V, Brody JA, Venturini C, Tanaka T, Rose LM, Oldmeadow C, Mazur J, Basu S, Frånberg M, Yang Q, Ligthart S, Hottenga JJ, Rumley A, Mulas A, de Craen AJ, Grotevendt A, Taylor KD, Delgado GE, Kifley A, Lopez LM, Berentzen TL, Mangino M, Bandinelli S, Morrison AC, Hamsten A, Tofler G, de Maat MP, Draisma HH, Lowe GD, Zoledziewska M, Sattar N, Lackner KJ, Völker U, McKnight B, Huang J, Holliday EG, McEvoy MA, Starr JM, Hysi PG, Hernandez DG, Guan W, Rivadeneira F, McArdle WL, Slagboom PE, Zeller T, Psaty BM, Uitterlinden AG, de Geus EJ, Stott DJ, Binder H, Hofman A, Franco OH, Rotter JI, Ferrucci L, Spector TD, Deary IJ, März W, Greinacher A, Wild PS, Cucca F, Boomsma DI, Watkins H, Tang W, Ridker PM, Jukema JW, Scott RJ, Mitchell P, Hansen T, O'Donnell CJ, Smith NL, Strachan DP, Dehghan A. Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study. PLoS One. 2017; 12(1):e0167742.View Related Profiles. PMID: 28107422; DOI: 10.1371/journal.pone.0167742;
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Rhee EP, Yang Q, Yu B, Liu X, Cheng S, Deik A, Pierce KA, Bullock K, Ho JE, Levy D, Florez JC, Kathiresan S, Larson MG, Vasan RS, Clish CB, Wang TJ, Boerwinkle E, O'Donnell CJ, Gerszten RE. An exome array study of the plasma metabolome. Nat Commun. 2016 07 25; 7:12360.View Related Profiles. PMID: 27453504; DOI: 10.1038/ncomms12360;
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de Vries PS, Chasman DI, Sabater-Lleal M, Chen MH, Huffman JE, Steri M, Tang W, Teumer A, Marioni RE, Grossmann V, Hottenga JJ, Trompet S, Müller-Nurasyid M, Zhao JH, Brody JA, Kleber ME, Guo X, Wang JJ, Auer PL, Attia JR, Yanek LR, Ahluwalia TS, Lahti J, Venturini C, Tanaka T, Bielak LF, Joshi PK, Rocanin-Arjo A, Kolcic I, Navarro P, Rose LM, Oldmeadow C, Riess H, Mazur J, Basu S, Goel A, Yang Q, Ghanbari M, Willemsen G, Rumley A, Fiorillo E, de Craen AJ, Grotevendt A, Scott R, Taylor KD, Delgado GE, Yao J, Kifley A, Kooperberg C, Qayyum R, Lopez LM, Berentzen TL, Räikkönen K, Mangino M, Bandinelli S, Peyser PA, Wild S, Trégouët DA, Wright AF, Marten J, Zemunik T, Morrison AC, Sennblad B, Tofler G, de Maat MP, de Geus EJ, Lowe GD, Zoledziewska M, Sattar N, Binder H, Völker U, Waldenberger M, Khaw KT, Mcknight B, Huang J, Jenny NS, Holliday EG, Qi L, Mcevoy MG, Becker DM, Starr JM, Sarin AP, Hysi PG, Hernandez DG, Jhun MA, Campbell H, Hamsten A, Rivadeneira F, Mcardle WL, Slagboom PE, Zeller T, Koenig W, Psaty BM, Haritunians T, Liu J, Palotie A, Uitterlinden AG, Stott DJ, Hofman A, Franco OH, Polasek O, Rudan I, Morange PE, Wilson JF, Kardia SL, Ferrucci L, Spector TD, Eriksson JG, Hansen T, Deary IJ, Becker LC, Scott RJ, Mitchell P, März W, Wareham NJ, Peters A, Greinacher A, Wild PS, Jukema JW, Boomsma DI, Hayward C, Cucca F, Tracy R, Watkins H, Reiner AP, Folsom AR, Ridker PM, O'Donnell CJ, Smith NL, Strachan DP, Dehghan A. A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. Hum Mol Genet. 2016 Jan 15; 25(2):358-70.View Related Profiles. PMID: 26561523; PMCID: PMC4715256; DOI: 10.1093/hmg/ddv454;
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Köttgen A, Hwang SJ, Larson MG, Van Eyk JE, Fu Q, Benjamin EJ, Dehghan A, Glazer NL, Kao WH, Harris TB, Gudnason V, Shlipak MG, Yang Q, Coresh J, Levy D, Fox CS. Uromodulin levels associate with a common UMOD variant and risk for incident CKD. J Am Soc Nephrol. 2010 Feb; 21(2):337-44.View Related Profiles. PMID: 19959715; PMCID: PMC2834540; DOI: 10.1681/ASN.2009070725;
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Liu C, Yang Q, Cupples LA, Meigs JB, Dupuis J. Selection of the most informative individuals from families with multiple siblings for association studies. Genet Epidemiol. 2009; 33(4):299-307.
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Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T, Voight BF, Bonnycastle LL, Jackson AU, Crawford G, Surti A, Guiducci C, Burtt NP, Parish S, Clarke R, Zelenika D, Kubalanza KA, Morken MA, Scott LJ, Stringham HM, Galan P, Swift AJ, Kuusisto J, Bergman RN, Sundvall J, Laakso M, Ferrucci L, Scheet P, Sanna S, Uda M, Yang Q, Lunetta KL, Dupuis J, de Bakker PI, O'Donnell CJ, Chambers JC, Kooner JS, Hercberg S, Meneton P, Lakatta EG, Scuteri A, Schlessinger D, Tuomilehto J, Collins FS, Groop L, Altshuler D, Collins R, Lathrop GM, Melander O, Salomaa V, Peltonen L, Orho-Melander M, Ordovas JM, Boehnke M, Abecasis GR, Mohlke KL, Cupples LA. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 2009 Jan; 41(1):56-65.View Related Profiles. PMID: 19060906; PMCID: PMC2881676; DOI: 10.1038/ng.291;
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Dehghan A, Köttgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, Boerwinkle E, Levy D, Hofman A, Astor BC, Benjamin EJ, van Duijn CM, Witteman JC, Coresh J, Fox CS. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet. 2008 Dec 6; 372(9654):1953-61.View Related Profiles. PMID: 18834626; PMCID: PMC2803340; DOI: 10.1016/S0140-6736(08)61343-4;
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Pearce EN, Wilson PW, Yang Q, Vasan RS, Braverman LE. Thyroid function and lipid subparticle sizes in patients with short-term hypothyroidism and a population-based cohort. J Clin Endocrinol Metab. 2008 Mar; 93(3):888-94.View Related Profiles. PMID: 18073305; PMCID: PMC2266946
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Yang Q, Kim SK, Sun F, Cui J, Larson MG, Vasan RS, Levy D, Schwartz F. Maternal influence on blood pressure suggests involvement of mitochondrial DNA in the pathogenesis of hypertension: the Framingham Heart Study. J Hypertens. 2007 Oct; 25(10):2067-73.View Related Profiles. PMID: 17885549
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Yang Q, Kathiresan S, Lin JP, Tofler GH, O'Donnell CJ. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. BMC Med Genet. 2007; 8 Suppl 1:S12.View Related Profiles. PMID: 17903294; PMCID: PMC1995619
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Hwang SJ, Yang Q, Meigs JB, Pearce EN, Fox CS. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. BMC Med Genet. 2007; 8 Suppl 1:S10.View Related Profiles. PMID: 17903292; PMCID: PMC1995611
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Schwartz JH, Li G, Yang Q, Suri V, Ross JJ, Alexander EA. Role of SNAREs and H+-ATPase in the targeting of proton pump-coated vesicles to collecting duct cell apical membrane. Kidney Int. 2007 Dec; 72(11):1310-5.View Related Profiles. PMID: 17805241
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Lin JP, O'Donnell CJ, Jin L, Fox C, Yang Q, Cupples LA. Evidence for linkage of red blood cell size and count: genome-wide scans in the Framingham Heart Study. Am J Hematol. 2007 Jul; 82(7):605-10.View Related Profiles. PMID: 17211848
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Yang Q, Biernacka JM, Chen MH, Houwing-Duistermaat JJ, Bergemann TL, Basu S, Fan R, Liu L, Bourgey M, Clerget-Darpoux F, Lin WY, Elston RC, Cupples LA, Apprey V, Cui J, Dupuis J, Ionita-Laza I, Li R, Lou X, Perdry H, Sherva R, Shugart YY, Suarez B, Wang H, Wormald H, Xing G, Xing C. Using linkage and association to identify and model genetic effects: summary of GAW15 Group 4. Genet Epidemiol. 2007; 31 Suppl 1:S34-42.View Related Profiles. PMID: 18046758
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Dupuis J, Albers K, Allen-Brady K, Cho K, Elston RC, Kappen HJ, Tang H, Thomas A, Thomson G, Tsung E, Yang Q, Zhang W, Zhao K, Zheng G, Ziegler JT. Effect of linkage disequilibrium between markers in linkage and association analyses. Genet Epidemiol. 2007; 31 Suppl 1:S139-48.View Related Profiles. PMID: 18046770
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Cupples LA, Arruda HT, Benjamin EJ, D'Agostino RB, Demissie S, DeStefano AL, Dupuis J, Falls KM, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Kathiresan S, Kiel DP, Laramie JM, Larson MG, Levy D, Liu CY, Lunetta KL, Mailman MD, Manning AK, Meigs JB, Murabito JM, Newton-Cheh C, O'Connor GT, O'Donnell CJ, Pandey M, Seshadri S, Vasan RS, Wang ZY, Wilk JB, Wolf PA, Yang Q, Atwood LD. The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet. 2007; 8 Suppl 1:S1.View Related Profiles. PMID: 17903291; PMCID: PMC1995613
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Cordell HJ, de Andrade M, Babron MC, Bartlett CW, Beyene J, Bickeböller H, Culverhouse R, Cupples LA, Daw EW, Dupuis J, Falk CT, Ghosh S, Goddard KA, Goode EL, Hauser ER, Martin LJ, Martinez M, North KE, Saccone NL, Schmidt S, Tapper W, Thomas D, Tritchler D, Vieland VJ, Wijsman EM, Wilcox MA, Witte JS, Yang Q, Ziegler A, Almasy L, Maccluer JW. Genetic Analysis Workshop 15: gene expression analysis and approaches to detecting multiple functional loci. BMC Proc. 2007; 1(Supp 1):S1.
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Wang, Y, Yang, Q, Rabinowitz, D. 16th Annual Meeting of the International-Genetic-Epidemiology-Society. Unbiased and efficient estimation of the effect of candidate genes on quantitative traits in the presence of population admixture. York. 2007.
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Wu H, Yang Q. American Society of Human Genetics Annual meeting. Comparing Methods for Association Test of Longitudinal or Multivariate Phenotypes. San Diego. 2007.
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Li G, Yang Q, Krishnan S, Alexander EA, Borkan SC, Schwartz JH. A novel cellular survival factor--the B2 subunit of vacuolar H+-ATPase inhibits apoptosis. Cell Death Differ. 2006 Dec; 13(12):2109-17.View Related Profiles. PMID: 16710359
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Kathiresan S, Yang Q, Larson MG, Lochner A, Tofler GH, Hirschhorn JN, Gabriel SB, O’Donnell CJ. Common Genetic Variation in Five Thrombosis Genes and Relations to Plasma Hemostatic Protein Level and Cardiovascular Disease Risk. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006; 26(6):1405-1412.
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Kathiresan S, Yang Q, Larson MG, Tofler GH, O'Donnell CJ. 79th Annual Scientific Session of the American-Heart-Association. A genome-wide association study to identify common sequence variants related to five circulating hemostatic factor proteins: The framingham heart study. Chicago. 2006.
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Liu, C; Cupples, LA; Yang, Q, Dupuis J. 15th Annual Meeting of the International-Genetic-Epidemiology-Society. Selection of cases in case-control studies using identity by descent sharing from families with multiple affected siblings. St Petersburg. 2006.
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Yang Q, Cui J, Chazaro I, Cupples LA, Demissie S. Power and type I error rate of false discovery rate approaches in genome-wide association studies. BMC Genet. 2005; 6 Suppl 1:S134.View Related Profiles. PMID: 16451593; PMCID: PMC1866802
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Mosher MJ, Martin LJ, Cupples LA, Yang Q, Dyer TD, Williams JT, North KE. Genotype-by-sex interaction in the regulation of high-density lipoprotein: the Framingham Heart Study. Hum Biol. 2005 Dec; 77(6):773-93. PMID: 16715837
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Yang Q, Guo CY, Cupples LA, Levy D, Wilson PW, Fox CS. Genome-wide search for genes affecting serum uric acid levels: the Framingham Heart Study. Metabolism. 2005 Nov; 54(11):1435-41.View Related Profiles. PMID: 16253630
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Hofmann MA, Yang Q, Harja E, Kedia P, Gregersen PK, Cupples LA, Schmidt AM, Hudson BI. The RAGE Gly82Ser polymorphism is not associated with cardiovascular disease in the Framingham offspring study. Atherosclerosis. 2005 Oct; 182(2):301-5.View Related Profiles. PMID: 16159602
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Kathiresan S, Gabriel SB, Yang Q, Lochner AL, Larson MG, Levy D, Tofler GH, Hirschhorn JN, O'Donnell CJ. Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels. Circulation. 2005 Sep 20; 112(12):1728-35.View Related Profiles. PMID: 16172282
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Fox CS, Yang Q, Cupples LA, Guo CY, Atwood LD, Murabito JM, Levy D, Mendelsohn ME, Housman DE, Shearman AM. Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart Study. J Clin Endocrinol Metab. 2005 Nov; 90(11):6257-62.View Related Profiles. PMID: 16144952
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McDermott DH, Yang Q, Kathiresan S, Cupples LA, Massaro JM, Keaney JF, Larson MG, Vasan RS, Hirschhorn JN, O'Donnell CJ, Murphy PM, Benjamin EJ. CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. Circulation. 2005 Aug 23; 112(8):1113-20.View Related Profiles. PMID: 16116069
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Herbert A, Liu C, Karamohamed S, Schiller J, Liu J, Yang Q, Wilson PW, Cupples LA, Meigs JB. The -174 IL-6 GG genotype is associated with a reduced risk of type 2 diabetes mellitus in a family sample from the National Heart, Lung and Blood Institute's Framingham Heart Study. Diabetologia. 2005 Aug; 48(8):1492-5.View Related Profiles. PMID: 15965659
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Li G, Yang Q, Alexander EA, Schwartz JH. Syntaxin 1A has a specific binding site in the H3 domain that is critical for targeting of H+-ATPase to apical membrane of renal epithelial cells. Am J Physiol Cell Physiol. 2005 Sep; 289(3):C665-72.View Related Profiles. PMID: 15872013
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Fox CS, Yang Q, Guo CY, Cupples LA, Wilson PW, Levy D, Meigs JB. Genome-wide linkage analysis to urinary microalbuminuria in a community-based sample: the Framingham Heart Study. Kidney Int. 2005 Jan; 67(1):70-4.View Related Profiles. PMID: 15610229
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Wilk JB, Manning AK, Dupuis J, Cupples LA, Larson MG, Newton-Cheh C, Demissie S, DeStefano AL, Hwang SJ, Liu C, Yang Q, Lunetta KL. International Genetic Epidemiology Society Annual Meeting. No evidence of major population substructure in the Framingham Heart Study. Park City. 2005.
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Guo CY, Cupples LA, Yang Q. International Genetic Epidemiology Society Annual Meeting. Testing informative missingness in family-based linkage and/or association study. Park City. 2005.
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Fox CS, Yang Q, Cupples LA, Guo CY, Larson MG, Leip EP, Wilson PW, Levy D. Genomewide linkage analysis to serum creatinine, GFR, and creatinine clearance in a community-based population: the Framingham Heart Study. J Am Soc Nephrol. 2004 Sep; 15(9):2457-61.View Related Profiles. PMID: 15339995
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Schlechter BL, Yang Q, Larson PS, Golubeva A, Blanchard RA, de las Morenas A, Rosenberg CL. Quantitative DNA fingerprinting may distinguish new primary breast cancer from disease recurrence. J Clin Oncol. 2004 May 15; 22(10):1830-8.View Related Profiles. PMID: 15143075
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Kathiresan S, Yang Q, Lochner A, et al. American Heart Association Annual Meeting. Gene-based Haplotypes at the plasminogen activator inhibitor-1 locus are associated with circulating plasminogen activator inhibitor-1 levels. Orlando. 2004.
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Cupples LA, Yang Q, Demissie S, Copenhafer D, Levy D. Description of the Framingham Heart Study data for Genetic Analysis Workshop 13. BMC Genet. 2003; 4 Suppl 1:S2.View Related Profiles. PMID: 14975070; PMCID: PMC1866454
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Yang Q, Chazaro I, Cui J, Guo CY, Demissie S, Larson M, Atwood LD, Cupples LA, DeStefano AL. Genetic analyses of longitudinal phenotype data: a comparison of univariate methods and a multivariate approach. BMC Genet. 2003; 4 Suppl 1:S29.View Related Profiles. PMID: 14975097; PMCID: PMC1866464
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Djoussé L, Knowlton B, Hayden M, Almqvist EW, Brinkman R, Ross C, Margolis R, Rosenblatt A, Durr A, Dode C, Morrison PJ, Novelletto A, Frontali M, Trent RJ, McCusker E, Gómez-Tortosa E, Mayo D, Jones R, Zanko A, Nance M, Abramson R, Suchowersky O, Paulsen J, Harrison M, Yang Q, Cupples LA, Gusella JF, MacDonald ME, Myers RH. Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease. Am J Med Genet A. 2003 Jun 15; 119A(3):279-82.View Related Profiles. PMID: 12784292
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Yang Q, Tofler GH, Cupples LA, Larson MG, Feng D, Lindpaintner K, Levy D, D'Agostino RB, O'Donnell CJ. A genome-wide search for genes affecting circulating fibrinogen levels in the Framingham Heart Study. Thromb Res. 2003 Apr 15; 110(1):57-64.View Related Profiles. PMID: 12877910
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McDermott DH, Fong AM, Yang Q, Sechler JM, Cupples LA, Merrell MN, Wilson PW, D'Agostino RB, O'Donnell CJ, Patel DD, Murphy PM. Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans. J Clin Invest. 2003 Apr; 111(8):1241-50.View Related Profiles. PMID: 12697743; PMCID: PMC152935
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Yang Q, Atwood LD, Cupples LA. Annual Meeting of International Genetic Epidemiology Society. Multivariate Variance Components Linkage Models for Longitudinal Phenotype Data using Gibbs Sampling Approaches. Redondo Beach. 2003.
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Xu G, Yang Q, Demissie S, et al. American Society of Human Genetics Annual meeting. Haplotype frequency and effect estimations for family-based association analyses. Los Angeles. 2003.
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O'Donnell CJ, Yang Q, Lochner A, et al. American Heart Association Annual Meeting. Associations of haplotypes of fibrinogen beta, alpha and gamma chain genes on chromosome 4 with circulating fibrinogen levels in men and women. Orlando. 2003.
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Yang Q, Rabinowitz D, Isasi C, Shea S. Adjusting for confounding due to population admixture when estimating the effect of candidate genes on quantitative traits. Hum Hered. 2000 Jul-Aug; 50(4):227-33. PMID: 10782014; DOI: 10.1159/000022920;
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Rabinowitz D, Yang Q. Testing for age-at-onset anticipation with affected parent-child pairs. Biometrics. 1999 Sep; 55(3):834-8. PMID: 11315014
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Yang Q, Rout MP, Akey CW. Three-dimensional architecture of the isolated yeast nuclear pore complex: functional and evolutionary implications. Mol Cell. 1998 Jan; 1(2):223-34.View Related Profiles. PMID: 9659919