Keywords
Last Name

Edward A. Alexander, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionNephrology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-8285
ORCID ORCID Icon0000-0002-6659-8186
Other Positions
TitleResearch Professor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics

TitleActive Staff Hospital Privileges
InstitutionBoston Medical Center
DepartmentMedicine

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Schwartz JH, Alexander EA. Adaptation of intercalated cells along the collecting duct to systemic acid/base changes. Kidney Int. 2010 Nov; 78(10):949-51. PMID: 21030969.
    View in: PubMed
  2. Schwartz JH, Li G, Yang Q, Suri V, Ross JJ, Alexander EA. Role of SNAREs and H+-ATPase in the targeting of proton pump-coated vesicles to collecting duct cell apical membrane. Kidney Int. 2007 Dec; 72(11):1310-5. PMID: 17805241.
    View in: PubMed
  3. Yang Q, Li G, Singh SK, Alexander EA, Schwartz JH. Vacuolar H+ -ATPase B1 subunit mutations that cause inherited distal renal tubular acidosis affect proton pump assembly and trafficking in inner medullary collecting duct cells. J Am Soc Nephrol. 2006 Jul; 17(7):1858-66. PMID: 16769747.
    View in: PubMed
  4. Li G, Yang Q, Krishnan S, Alexander EA, Borkan SC, Schwartz JH. A novel cellular survival factor--the B2 subunit of vacuolar H+-ATPase inhibits apoptosis. Cell Death Differ. 2006 Dec; 13(12):2109-17. PMID: 16710359.
    View in: PubMed
  5. Li G, Yang Q, Alexander EA, Schwartz JH. Syntaxin 1A has a specific binding site in the H3 domain that is critical for targeting of H+-ATPase to apical membrane of renal epithelial cells. Am J Physiol Cell Physiol. 2005 Sep; 289(3):C665-72. PMID: 15872013.
    View in: PubMed
  6. Nicoletta JA, Ross JJ, Li G, Cheng Q, Schwartz J, Alexander EA, Schwartz JH. Munc-18-2 regulates exocytosis of H(+)-ATPase in rat inner medullary collecting duct cells. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1366-74. PMID: 15240346.
    View in: PubMed
  7. Li G, Alexander EA, Schwartz JH. Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis. J Biol Chem. 2003 May 30; 278(22):19791-7. PMID: 12651853.
    View in: PubMed
  8. Banerjee A, Li G, Alexander EA, Schwartz JH. Role of SNAP-23 in trafficking of H+-ATPase in cultured inner medullary collecting duct cells. Am J Physiol Cell Physiol. 2001 Apr; 280(4):C775-81. PMID: 11245593.
    View in: PubMed
  9. Banerjee A, Shih T, Alexander EA, Schwartz JH. SNARE proteins regulate H(+)-ATPase redistribution to the apical membrane in rat renal inner medullary collecting duct cells. J Biol Chem. 1999 Sep 10; 274(37):26518-22. PMID: 10473613.
    View in: PubMed
  10. Alexander EA, Brown D, Shih T, McKee M, Schwartz JH. Effect of acidification on the location of H+-ATPase in cultured inner medullary collecting duct cells. Am J Physiol. 1999 Mar; 276(3 Pt 1):C758-63. PMID: 10070004.
    View in: PubMed
  11. Obrador G, Yuan H, Shih TM, Wang YH, Shia MA, Alexander EA, Schwartz JH. Characterization of anion exchangers in an inner medullary collecting duct cell line. J Am Soc Nephrol. 1998 May; 9(5):746-54. PMID: 9596071.
    View in: PubMed
  12. Alexander EA, Shih T, Schwartz JH. H+ secretion is inhibited by clostridial toxins in an inner medullary collecting duct cell line. Am J Physiol. 1997 Dec; 273(6 Pt 2):F1054-7. PMID: 9435696.
    View in: PubMed
  13. Schwartz GJ, Brown D, Mankus R, Alexander EA, Schwartz JH. Low pH enhances expression of carbonic anhydrase II by cultured rat inner medullary collecting duct cells. Am J Physiol. 1994 Feb; 266(2 Pt 1):C508-14. PMID: 8141264.
    View in: PubMed
  14. Schwartz JH, Masino SA, Nichols RD, Alexander EA. Intracellular modulation of acid secretion in rat inner medullary collecting duct cells. Am J Physiol. 1994 Jan; 266(1 Pt 2):F94-101. PMID: 8304489.
    View in: PubMed
  15. Slotki I, Schwartz JH, Alexander EA. Interrelationship between cell pH and cell calcium in rat inner medullary collecting duct cells. Am J Physiol. 1993 Aug; 265(2 Pt 1):C432-8. PMID: 8368272.
    View in: PubMed
  16. Mankus R, Schwartz JH, Alexander EA. Acidification adaptation in cultured inner medullary collecting duct cells. Am J Physiol. 1993 May; 264(5 Pt 2):F765-9. PMID: 8388650.
    View in: PubMed
  17. Alexander EA, Schwartz JH. Regulation of acidification in the rat inner medullary collecting duct. Am J Kidney Dis. 1991 Nov; 18(5):612-8. PMID: 1659187.
    View in: PubMed
  18. Slotki IN, Schwartz JH, Alexander EA. Na(+)-H+ exchange is stimulated by protein kinase C activation in inner medullary collecting duct cells. Am J Physiol. 1990 Oct; 259(4 Pt 2):F666-71. PMID: 2171360.
    View in: PubMed
  19. Schwartz JH, Bengele HH, McNamara ER, Alexander EA. Vasopressin-enhanced urea transport by rat inner medullary collecting duct cells in culture. Cell Tissue Kinet. 1990 Sep; 23(5):487-93. PMID: 2245445.
    View in: PubMed
  20. Siskind MS, Alexander EA, Schwartz JH. Regulation of cGMP production by intracellular alkalinization in cultured rat inner medullary collecting duct cells. Biochem Biophys Res Commun. 1990 Jul 31; 170(2):860-6. PMID: 2166512.
    View in: PubMed
  21. Slotki IN, Schwartz JH, Alexander EA. Effect of increases in cytosolic Ca2+ on inner medullary collecting duct cell pH. Am J Physiol. 1989 Aug; 257(2 Pt 2):F210-7. PMID: 2764121.
    View in: PubMed
  22. Bengele HH, McNamara ER, Schwartz JH, Alexander EA. Acidification adaptation along the inner medullary collecting duct. Am J Physiol. 1988 Dec; 255(6 Pt 2):F1155-9. PMID: 3144183.
    View in: PubMed
  23. McCoy CE, Selvaggio AM, Alexander EA, Schwartz JH. Adenosine triphosphate depletion induces a rise in cytosolic free calcium in canine renal epithelial cells. J Clin Invest. 1988 Oct; 82(4):1326-32. PMID: 2844853.
    View in: PubMed
  24. Bengele HH, McNamara ER, Schwartz JH, Alexander EA. Suppression of acidification along inner medullary collecting duct. Am J Physiol. 1988 Aug; 255(2 Pt 2):F307-12. PMID: 3136664.
    View in: PubMed
  25. Selvaggio AM, Schwartz JH, Bengele HH, Gordon FD, Alexander EA. Mechanisms of H+ secretion by inner medullary collecting duct cells. Am J Physiol. 1988 Mar; 254(3 Pt 2):F391-400. PMID: 3348416.
    View in: PubMed
  26. Griffing GT, Wilson TE, Alexander EA, Bengele HH, Perrone RD, Melby JC. Biphasic 19-nor-deoxycorticosterone excretion after adrenal enucleation is associated with altered adrenal mitochondrial cytochrome P450 11 beta-, 18-, and 19-hydroxylase activities. Endocrinology. 1987 Aug; 121(2):645-9. PMID: 3496214.
    View in: PubMed
  27. Bengele HH, McNamara ER, Schwartz JH, Alexander EA. Inner medullary collecting duct function during rebound alkalemia. Am J Physiol. 1987 Apr; 252(4 Pt 2):F712-6. PMID: 3565581.
    View in: PubMed
  28. Selvaggio AM, Schwartz JH, Bengele HH, Alexander EA. Kinetics of the Na+-H+ antiporter as assessed by the change in intracellular pH in MDCK cells. Am J Physiol. 1986 Oct; 251(4 Pt 1):C558-62. PMID: 3020990.
    View in: PubMed
  29. Bengele HH, Schwartz JH, McNamara ER, Alexander EA. Chronic metabolic acidosis augments acidification along the inner medullary collecting duct. Am J Physiol. 1986 Apr; 250(4 Pt 2):F690-4. PMID: 3963206.
    View in: PubMed
  30. Bengele HH, Schwartz JH, McNamara ER, Alexander EA. Effect of buffer infusion during acute respiratory acidosis. Am J Physiol. 1986 Jan; 250(1 Pt 2):F115-9. PMID: 3942218.
    View in: PubMed
  31. Perrone RD, Bengele HH, Alexander EA. Sodium retention after adrenal enucleation. Am J Physiol. 1986 Jan; 250(1 Pt 1):E1-12. PMID: 3002187.
    View in: PubMed
  32. Schiff MJ, Schwartz JH, Bengele HH, Dale SL, Melby JC, Alexander EA. Mineralocorticoid activity of 19-nor-corticosterone and 19-nor-progesterone in the toad bladder. Endocrinology. 1984 Oct; 115(4):1235-8. PMID: 6434287.
    View in: PubMed
  33. Bengele HH, McNamara ER, Alexander EA. Effect of acute thyroparathyroidectomy on nephron acidification. Am J Physiol. 1984 May; 246(5 Pt 2):F569-74. PMID: 6720962.
    View in: PubMed
  34. Perrone RD, Alexander EA, Bengele HH, Schwartz JH. Effect of aldosterone and dexamethasone pretreatment on sodium transport in rat distal colon in vitro. Pflugers Arch. 1984 Mar; 400(3):257-61. PMID: 6728647.
    View in: PubMed
  35. Bengele HH, Mathias R, Perkins JH, McNamara ER, Alexander EA. Impaired renal and extrarenal potassium adaptation in old rats. Kidney Int. 1983 May; 23(5):684-90. PMID: 6308326.
    View in: PubMed
  36. Bengele HH, Graber ML, Alexander EA. Effect of respiratory acidosis on acidification by the medullary collecting duct. Am J Physiol. 1983 Jan; 244(1):F89-94. PMID: 6401406.
    View in: PubMed
  37. Graber ML, Bengele HH, Alexander EA. Elevated urinary PCO2 in the rat: an intrarenal event. Kidney Int. 1982 Jun; 21(6):795-9. PMID: 6290741.
    View in: PubMed
  38. Perrone RD, Bengele HH, Dale SL, Melby JC, Alexander EA. Mineralocorticoid activity of 19-nor-DOC and 19-OH-DOC in adrenalectomized rat. Am J Physiol. 1982 May; 242(5):E305-8. PMID: 7081431.
    View in: PubMed
  39. Bengele HH, Alexander EA. Effect of adrenal enucleation on inner medullary collecting duct function in the rat. Am J Physiol. 1982 May; 242(5):F453-6. PMID: 7081434.
    View in: PubMed
  40. Churchill SE, Bengele HH, Alexander EA. Renal function in the term pregnant rat: a micropuncture study. Ren Physiol. 1982; 5(1):1-9. PMID: 7200629.
    View in: PubMed
  41. Graber ML, Bengele HH, Schwartz JH, Alexander EA. pH and PCO2 profiles of the rat inner medullary collecting duct. Am J Physiol. 1981 Dec; 241(6):F659-68. PMID: 6798882.
    View in: PubMed
  42. Graber ML, Bengele HH, Mroz E, Lechene C, Alexander EA. Acute metabolic acidosis augments collecting duct acidification rate in the rat. Am J Physiol. 1981 Dec; 241(6):F669-76. PMID: 7325236.
    View in: PubMed
  43. Perrone RD, Schwartz JH, Bengele HH, Dale SL, Melby JC, Alexander EA. Mineralocorticoid activity of 19-nor-DOC and 19-OH-DOC in toad bladder. Am J Physiol. 1981 Nov; 241(5):E406-9. PMID: 6795931.
    View in: PubMed
  44. Churchill S, Bengele HH, Melby JC, Alexander EA. Role of aldosterone in sodium retention of pregnancy in the rat. Am J Physiol. 1981 Mar; 240(3):R175-81. PMID: 7212089.
    View in: PubMed
  45. Bengele HH, Mathias RS, Perkins JH, Alexander EA. Urinary concentrating defect in the aged rat. Am J Physiol. 1981 Feb; 240(2):F147-50. PMID: 7468799.
    View in: PubMed
  46. Bengele HH, Mathias RS, Alexander EA. Impaired natriuresis after volume expansion in the aged rat. Ren Physiol. 1981; 4(1):22-9. PMID: 7302356.
    View in: PubMed
  47. Alexander EA, Churchill S, Bengele HH. Renal hemodynamics and volume homeostasis during pregnancy in the rat. Kidney Int. 1980 Aug; 18(2):173-8. PMID: 7003198.
    View in: PubMed
  48. Churchi-l SE, Bengele HH, Alexander EA. Sodium balance during pregnancy in the rat. Am J Physiol. 1980 Jul; 239(1):R143-8. PMID: 7396030.
    View in: PubMed
  49. Bengele HH, Alexander EA, Lechene CP. Calcium and magnesium transport along the inner medullary collecting duct of the rat. Am J Physiol. 1980 Jul; 239(1):F24-9. PMID: 7395992.
    View in: PubMed
  50. Eisenstein B, Bengele H, Alexander EA. Sodium excretion after adrenal enucleation and during adrenal regeneration hypertension. Proc Soc Exp Biol Med. 1980 Jul; 164(3):322-5. PMID: 7403100.
    View in: PubMed
  51. Evan A, Huser J, Bengele HH, Alexander EA. The effect of alterations in dietary potassium on collecting system morphology in the rat. Lab Invest. 1980 Jun; 42(6):668-75. PMID: 7392572.
    View in: PubMed
  52. Bengele HH, Lechene C, Alexander EA. Sodium and chloride transport along the inner medullary collecting duct: effect of saline expansion. Am J Physiol. 1980 Jun; 238(6):F504-8. PMID: 7386629.
    View in: PubMed
  53. Eisenstein B, Bengele HH, Alexander EA. Sodium balance after adrenal enucleation. Am J Physiol. 1980 Mar; 238(3):E220-2. PMID: 7369353.
    View in: PubMed
  54. Bengele HH, Lechene CP, Alexander EA. Phosphate transport along the inner medullary collecting duct of the rat. Am J Physiol. 1979 Jul; 237(1):F48-54. PMID: 464060.
    View in: PubMed
  55. Bengele HH, McNamara ER, Alexander EA. Potassium secretion along the inner medullary collecting duct. Am J Physiol. 1979 Mar; 236(3):F278-82. PMID: 426070.
    View in: PubMed
  56. Bernard DB, Alexander EA, Couser WG, Levinsky NG. Renal sodium retention during volume expansion in experimental nephrotic syndrome. Kidney Int. 1978 Nov; 14(5):478-85. PMID: 750693.
    View in: PubMed
  57. Bengele HH, Evan A, McNamara ER, Alexander EA. Tubular sites of potassium regulation in the normal and uninephrectomized rat. Am J Physiol. 1978 Feb; 234(2):F146-53. PMID: 623306.
    View in: PubMed
  58. Bengele HH, McNamara ER, Alexander EA. Use of lissamine green for micropuncture: a comparison of two methods (39896). Proc Soc Exp Biol Med. 1977 Oct; 156(1):155-7. PMID: 909883.
    View in: PubMed
  59. Bengele HH, McNamara ER, Alexander EA. Natriuresis after adrenal enucleation: effect of spironolactone and dexamethasone. Am J Physiol. 1977 Jul; 233(1):F8-12. PMID: 879325.
    View in: PubMed
  60. Bengele HH, McNamara ER, Alexander EA. Volume-expansion natriuresis: nephron function beyond the superficial late distal tubule. Am J Physiol. 1977 Jun; 232(6):F566-70. PMID: 879291.
    View in: PubMed
  61. Alexander EA, Bengele HH, McNamara ER. Effect of adrenal enucleation on sodium excretion in the rat. Am J Physiol. 1976 Nov; 231(5 Pt. 1):1421-8. PMID: 998785.
    View in: PubMed
  62. Alexander EA, Doner DW, Auld RB, Levinsky NG. Tubular reabsorption of sodium during acute and chronic volume expansion in man. J Clin Invest. 1972 Sep; 51(9):2370-9. PMID: 4639021.
    View in: PubMed
  63. Morris CR, Alexander EA, Bruns FJ, Levinsky NG. Restoration and maintenance of glomerular filtration by mannitol during hypoperfusion of the kidney. J Clin Invest. 1972 Jun; 51(6):1555-64. PMID: 5024047.
    View in: PubMed
  64. Davidman M, Lalone RC, Alexander EA, Levinsky NG. Some micropuncture techniques in the rat. Am J Physiol. 1971 Oct; 221(4):1110-4. PMID: 5111251.
    View in: PubMed
  65. Auld RB, Alexander EA, Levinsky NG. Proximal tubular function in dogs with thoracic caval constriction. J Clin Invest. 1971 Oct; 50(10):2150-8. PMID: 5116206.
    View in: PubMed
  66. Alexander EA, Levinsky NG. An extrarenal mechanism of potassium adaptation. J Clin Invest. 1968 Apr; 47(4):740-8. PMID: 5641615.
    View in: PubMed
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