Keywords
Last Name

Rutao Cui, MD, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics
Address609 Albany St (J Bldg)
Boston MA 02118
Phone(617) 414-1370
ORCID ORCID Icon0000-0002-4377-9988
Other Positions
TitleProfessor
InstitutionBoston University School of Medicine
DepartmentDermatology

 Awards and Honors

Start-EndDescription
2000Japan: Takeda Science Award
2002Shanghai Scientific Technical Development Prize
2002World Health Organization (WHO): IARC Fellowship Award
2007Charles A. King Trust Postdoctoral Fellowship Award
2009American Cancer Society (ACS): American Cancer Society Research Scholar
2009American Cancer Society, Chicago IL: IL division Outstanding Mentor
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R, Pandolfi PP, Wei W. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discov. 2017 Apr; 7(4):424-441. PMID: 28174173.
    View in: PubMed
  2. Zeng Q, Zhao RX, Chen J, Li Y, Li XD, Liu XL, Zhang WM, Quan CS, Wang YS, Zhai YX, Wang JW, Youssef M, Cui R, Liang J, Genovese N, Chow LT, Li YL, Xu ZX. O-linked GlcNAcylation elevated by HPV E6 mediates viral oncogenesis. Proc Natl Acad Sci U S A. 2016 Aug 16; 113(33):9333-8. PMID: 27482104.
    View in: PubMed
  3. Li X, Miao X, Wang H, Wang Y, Li F, Yang Q, Cui R, Li B. Association of Serum Uric Acid Levels in Psoriasis: A Systematic Review and Meta-Analysis. Medicine (Baltimore). 2016 May; 95(19):e3676. PMID: 27175702.
    View in: PubMed
  4. Cao J, Dai X, Wan L, Wang H, Zhang J, Goff PS, Sviderskaya EV, Xuan Z, Xu Z, Xu X, Hinds P, Flaherty KT, Faller DV, Goding CR, Wang Y, Wei W, Cui R. The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth. Sci Signal. 2015 Sep 1; 8(392):ra87. PMID: 26329581.
    View in: PubMed
  5. Luo C, Pietruska JR, Sheng J, Bronson RT, Hu MG, Cui R, Hinds PW. Expression of oncogenic BRAFV600E in melanocytes induces Schwannian differentiation in vivo. Pigment Cell Melanoma Res. 2015 Sep; 28(5):603-6. PMID: 26036358.
    View in: PubMed
  6. Chen Z, Meng Z, Jia L, Cui R. The tumor microenvironment and cancer. Biomed Res Int. 2014; 2014:573947. PMID: 25587537.
    View in: PubMed
  7. Yang R, Zheng Y, Li L, Liu S, Burrows M, Wei Z, Nace A, Herlyn M, Cui R, Guo W, Cotsarelis G, Xu X. Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors. Nat Commun. 2014; 5:5807. PMID: 25510211.
    View in: PubMed
  8. Li J, Ballim D, Rodriguez M, Cui R, Goding CR, Teng H, Prince S. The anti-proliferative function of the TGF-ß1 signaling pathway involves the repression of the oncogenic TBX2 by its homologue TBX3. J Biol Chem. 2014 Dec 19; 289(51):35633-43. PMID: 25371204.
    View in: PubMed
  9. Xu HG, Zhai YX, Chen J, Lu Y, Wang JW, Quan CS, Zhao RX, Xiao X, He Q, Werle KD, Kim HG, Lopez R, Cui R, Liang J, Li YL, Xu ZX. LKB1 reduces ROS-mediated cell damage via activation of p38. Oncogene. 2015 Jul; 34(29):3848-59. PMID: 25263448.
    View in: PubMed
  10. Werle K, Chen J, Xu HG, Zhao RX, He Q, Lu C, Cui R, Liang J, Li YL, Xu ZX. Liver kinase B1 regulates the centrosome via PLK1. Cell Death Dis. 2014; 5:e1157. PMID: 24722282.
    View in: PubMed
  11. Takashima A, English B, Chen Z, Cao J, Cui R, Williams RM, Faller DV. Protein kinase Cd is a therapeutic target in malignant melanoma with NRAS mutation. ACS Chem Biol. 2014 Apr 18; 9(4):1003-14. PMID: 24506253.
    View in: PubMed
  12. Wu J, Dong F, Wang RA, Wang J, Zhao J, Yang M, Gong W, Cui R, Dong L. Central role of cellular senescence in TSLP-induced airway remodeling in asthma. PLoS One. 2013; 8(10):e77795. PMID: 24167583.
    View in: PubMed
  13. Lu C, Chen J, Xu HG, Zhou X, He Q, Li YL, Jiang G, Shan Y, Xue B, Zhao RX, Wang Y, Werle KD, Cui R, Liang J, Xu ZX. MIR106B and MIR93 prevent removal of bacteria from epithelial cells by disrupting ATG16L1-mediated autophagy. Gastroenterology. 2014 Jan; 146(1):188-99. PMID: 24036151.
    View in: PubMed
  14. Cao J, Wan L, Hacker E, Dai X, Lenna S, Jimenez-Cervantes C, Wang Y, Leslie NR, Xu GX, Widlund HR, Ryu B, Alani RM, Dutton-Regester K, Goding CR, Hayward NK, Wei W, Cui R. MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Mol Cell. 2013 Aug 22; 51(4):409-22. PMID: 23973372.
    View in: PubMed
  15. Luo C, Sheng J, Hu MG, Haluska FG, Cui R, Xu Z, Tsichlis PN, Hu GF, Hinds PW. Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. Cancer Res. 2013 Jul 15; 73(14):4337-48. PMID: 23650282.
    View in: PubMed
  16. Liu F, Cao J, Wu J, Sullivan K, Shen J, Ryu B, Xu Z, Wei W, Cui R. Stat3-targeted therapies overcome the acquired resistance to vemurafenib in melanomas. J Invest Dermatol. 2013 Aug; 133(8):2041-9. PMID: 23344460.
    View in: PubMed
  17. Wang RA, Li QL, Li ZS, Zheng PJ, Zhang HZ, Huang XF, Chi SM, Yang AG, Cui R. Apoptosis drives cancer cells proliferate and metastasize. J Cell Mol Med. 2013 Jan; 17(1):205-11. PMID: 23305095.
    View in: PubMed
  18. Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrel C, Amos CI, Wei Q, Lee JE, Zhang J, Kupper TS, Qureshi AA, Cui R, Han J, Fisher DE, Arany Z. PGC-1 coactivators regulate MITF and the tanning response. Mol Cell. 2013 Jan 10; 49(1):145-57. PMID: 23201126.
    View in: PubMed
  19. Liu F, Cao J, Lv J, Dong L, Pier E, Xu GX, Wang RA, Xu Z, Goding C, Cui R. TBX2 expression is regulated by PAX3 in the melanocyte lineage. Pigment Cell Melanoma Res. 2013 Jan; 26(1):67-77. PMID: 23020925.
    View in: PubMed
  20. Liu S, Tetzlaff MT, Cui R, Xu X. miR-200c inhibits melanoma progression and drug resistance through down-regulation of BMI-1. Am J Pathol. 2012 Nov; 181(5):1823-35. PMID: 22982443.
    View in: PubMed
  21. Xiao X, He Q, Lu C, Werle KD, Zhao RX, Chen J, Davis BC, Cui R, Liang J, Xu ZX. Metformin impairs the growth of liver kinase B1-intact cervical cancer cells. Gynecol Oncol. 2012 Oct; 127(1):249-55. PMID: 22735790.
    View in: PubMed
  22. Dong L, Li Y, Cao J, Liu F, Pier E, Chen J, Xu Z, Chen C, Wang RA, Cui R. FGF2 regulates melanocytes viability through the STAT3-transactivated PAX3 transcription. Cell Death Differ. 2012 Apr; 19(4):616-22. PMID: 21997191.
    View in: PubMed
  23. Wang S, Wang H, Davis BC, Liang J, Cui R, Chen SJ, Xu ZX. PARP1 inhibitors attenuate AKT phosphorylation via the upregulation of PHLPP1. Biochem Biophys Res Commun. 2011 Aug 26; 412(2):379-84. PMID: 21821012.
    View in: PubMed
  24. Dong L, Wen J, Pier E, Zhang X, Zhang B, Dong F, Ziegler N, Mysz M, Armenta R, Cui R. Melanocyte-stimulating hormone directly enhances UV-Induced DNA repair in keratinocytes by a xeroderma pigmentosum group A-dependent mechanism. Cancer Res. 2010 May 1; 70(9):3547-56. PMID: 20388774.
    View in: PubMed
  25. Li H, Li H, Ziegler N, Cui R, Liu J. Recent patents on PCSK9: a new target for treating hypercholesterolemia. Recent Pat DNA Gene Seq. 2009; 3(3):201-12. PMID: 19601924.
    View in: PubMed
  26. Yang G, Li Y, Nishimura EK, Xin H, Zhou A, Guo Y, Dong L, Denning MF, Nickoloff BJ, Cui R. Inhibition of PAX3 by TGF-beta modulates melanocyte viability. Mol Cell. 2008 Nov 21; 32(4):554-63. PMID: 19026785.
    View in: PubMed
  27. Cui R, Widlund HR, Feige E, Lin JY, Wilensky DL, Igras VE, D'Orazio J, Fung CY, Schanbacher CF, Granter SR, Fisher DE. Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell. 2007 Mar 9; 128(5):853-64. PMID: 17350573.
    View in: PubMed
  28. D'Orazio JA, Nobuhisa T, Cui R, Arya M, Spry M, Wakamatsu K, Igras V, Kunisada T, Granter SR, Nishimura EK, Ito S, Fisher DE. Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature. 2006 Sep 21; 443(7109):340-4. PMID: 16988713.
    View in: PubMed
  29. Accardi R, Dong W, Smet A, Cui R, Hautefeuille A, Gabet AS, Sylla BS, Gissmann L, Hainaut P, Tommasino M. Skin human papillomavirus type 38 alters p53 functions by accumulation of deltaNp73. EMBO Rep. 2006 Mar; 7(3):334-40. PMID: 16397624.
    View in: PubMed
  30. Accardi R, Dong W, Smet A, Cui R, Hautefeuille A, Gabet AS, Sylla BS, Gissmann L, Hainaut P, Tommasino M. Skin human papillomavirus type 38 alters p53 functions via accumulation of DeltaNp73. EMBO Reports. 2006; 7:334-340.
  31. Cui R, Nguyen TT, Taube JH, Stratton SA, Feuerman MH, Barton MC. Family members p53 and p73 act together in chromatin modification and direct repression of alpha-fetoprotein transcription. J Biol Chem. 2005 Nov 25; 280(47):39152-60. PMID: 16203738.
    View in: PubMed
  32. Cui R, He J, Zhang F, Wang B, Ding H, Shen H, Li Y, Chen X. Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to alpha-fetoprotein. Br J Cancer. 2003 Jun 16; 88(12):1878-82. PMID: 12799630.
    View in: PubMed
  33. Cui R, Wang B, Zhang F, Chen G, Yin S. Suppressive effect of herbal compound 861 on chemical hepatocarcinogenesis in rats. Chin Med J (Engl). 2003 Mar; 116(3):378-82. PMID: 12781041.
    View in: PubMed
  34. Cui R*, He Jinchun, Wang Baoen, Zhang Fukui, Chen Guangyong, Yin Shanshan, Shen Hong. Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats. Cancer Chemotherapy and Pharmacology (* Corresponding author). 2003; 51:75-80.
  35. Cui R*, He Jinchun, Zhang Fukui, Wang Baoen, Shen Hong, Li Yimei, and Chen Xiao Hong. . Diagnostic Value for Protein Induced by Vitamin K Absence, Hepatoma- specific Band of Serum Gamma-glutamyl Transferase as Hepatocellular Carcinoma Markers Complementary to a- fetoprotein. British J of Cancer (* Corresponding author). 2003; 88:1874- 1878.
  36. Cui R*, Wang Baoen, Zhang Fukui, Chen Guangyong, Yin Shanshan. Supressive effect of herbal compound 861 on chemical hepatocarcinogenesis in rats. Chinese Medical Journal (Engl). (* Corresponding author). 2003; 116:378-382.
  37. Cui R, He J, Wang B, Zhang F, Chen G, Yin S, Shen H. Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats. Cancer Chemother Pharmacol. 2003 Jan; 51(1):75-80. PMID: 12497209.
    View in: PubMed
  38. Cui R, Wang B, Zhang F, Yin S. [Progress in the research on the HBV mutants associeted with lamivudine therapy]. Zhonghua Gan Zang Bing Za Zhi. 2002 Jun; 10(3):238-40. PMID: 12113694.
    View in: PubMed
  39. Zhang F, Jia J, Cui R, Wang B, Wang H. Clinical features of forty patients with primary biliary cirrhosis. Chin Med J (Engl). 2002 Jun; 115(6):904-8. PMID: 12123563.
    View in: PubMed
  40. Cui R, Wang B, Zhang F, et al. Clinical prevention of Lamivudine-induced YMDD mutation. Chinese Journal of Infection. 2002; 20:54-56.
  41. Cui R, Wang B, Zhang F, et al. Novel Lamivudine-induced HBV mutation. Chinese Journal of Hepatology. 2002; 10:73-75.
  42. Cui R*, Wang B, Ding H, Shen H, Li Y, Chen X. Usefulness of determining a protein induced by vitamin K absence in detection of hepatocellular carcinoma. Chinese Medical Journal (Engl) (* Corresponding author). 2002; 115:42-5.
  43. Cui R, Wang B, Zhang F. Experimental gene therapy for hepatis B infection. Clinical Hepatology. 2002; 19:2-5.
  44. Cui R, Wang B, Ding H, Shen H, Li Y, Chen X. Usefulness of determining a protein induced by vitamin K absence in detection of hepatocellular carcinoma. Chin Med J (Engl). 2002 Jan; 115(1):42-5. PMID: 11930656.
    View in: PubMed
  45. Cui R, Wang B, Ding H, et al. Clinical evaluation of PIVKAII in the diagnosis of hepatocellular carcinoma. Chinese Journal of Digestion. 2001; 21:571-572.
  46. Cui R, Zhang S, Zhu L. Clinical trial for lansoprazole in GERD. Clinical Gastroenterology (China). 2001; 5:279-281.
  47. Cui R*, Cai Gan, Qiuhong Yang, et al. Effect of tretinoic acid on experimentally induced dysplasia of gastric epithelial cell apoptosis and regulation gene (Bcl-2, Fas, ICE). Chinese Journal of Digestive Diseases (Blackwell Synergy) (* Corresponding author). 2001; 2:5-8.
  48. Jia J, Cui R. Strategies of clinical prevention of hepatic toxicity of NSAIDs. Hepatology (China). 2001; 7:1-3.
  49. Cui R, Zhu L. Clinical Trial of Lizhuchangle. Current Medicine (China). 2001; 7:741.
  50. Cui R, Jia J, Wang B. Treatment of hepatic dysplasia. Chinese Journal of Digestion. 2001; 21:671-674.
  51. Cui R, Jia J, Zhang F, et al. Clinical trial for the treatment of HCV infection using Interferon in combination with Ribavirin. Chinese Journal of Internal Medicine. 2001; 40:643-645.
  52. Cui R*, Cai G, Yang Q, et al. Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methy 1-N-nitrosoguanidine: effect on cell apoptosis and statement of its regulatory genes. World Journal of Gastroenterology (* Corresponding author). 2001; 5:471-78.
  53. Zheng S, Cui R. Experimental study for the treatment of Ulcerative Colitis. Shanghai Medical Journal. 2000; 34:10-12.
  54. Cui R, Cai G, Xie J. Treatment of gastric dysplasia. Journal of Traditional Chinese Medicine. 2000; 41:365-368.
  55. Cui R, Cai G, Yang Q, et al. Effect of tretinoic acid on experimentally induced rat dysplasia of gastric epithelial cell. Chinese Journal of Digestion. 2000; 20:82-84.
  56. Cui R, Cai G, Yang Q, et al. Effect of Leweijian on experimental induced dysplasia of gastric epithelium. Chinese journal of integrated digestion. 2000; 8(2):3-7.
  57. Cui R, Xie J. Evaluation of undiagnostic treatment. Acta of Jiejiang Medical University. 1999; 23:10-13.
  58. Cui R,Yin Z. The Influence of Yangwei Granule on the Structure of Gastric Mucosa and Plasma in Rat Models with Chronic Atrophic Gastritis. Chinese Drug Research and Clinical Pharmacology. 1999; 10:273-275.
  59. Cui R. Clinical treatment of precancerous stomach. Chinese Journal of Traditional Chinese Medicine. 1999; 40:43-47.
  60. Cui R, Cai G, Xie J. Clinical trial for gastric dysplasia. Acta of Shanghai Medical University of TCM. 1999; 13:61-64.
  61. Cui R. Clinical treatment of ankylosing spondylitis. Chinese Journal of Traditional Chinese Medicine. 1999; 40:655-656.
  62. Cui R, Yin Z. Preclinical study of Yangwei Granule in acute gastritis. Chinese Journal of Medicine and Pharmacology. 1998; 11(6):27-31.
  63. Cui R. Clinical treatment of COPD. Chinese Emergency Medical Journal. 1997; 11:12-14.
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