Suryaram Gummuluru, PhD
Professor
Boston University School of Medicine
Dept of Microbiology

PhD, University of Rochester
MS, University of Rochester




Our research is broadly focused on the role of dendritic cells (DCs) in the initiation and propagation of HIV-1 replication. Since dendritic cells are believed to be the first immune competent cells to encounter virus in the genital mucosa, a thorough understanding of the HIV-DC interactions is of paramount importance. DCs can capture virus particles independently of CD4 and co-receptor complexes, and retain them in an infectious state for an extended period of time. These virus-bearing DCs may then facilitate a more efficient spread of virus to replication-permissive CD4+ T cells. Our recent work has identified a novel glycosphingolipid dependent mechanism of virus attachment to DCs. The fate of the virus particle post-attachment in DCs remains unclear. Virion trafficking within the DC bypasses conventional endocytic organelles, i.e., endosomes and lysosomes. Virus localization within this novel vesicular compartment not only has the potential to protect the invading HIV from being degraded, but also creates a latent reservoir of virus, which could present a major challenge for eradication by antiretroviral therapy. Furthermore, the mechanism of subsequent return of infectious virus particles to the cell surface and the method of subsequent transmission to T cells remains unclear. Current studies utilizing biochemical and microscopic approaches are underway to monitor HIV-1 trafficking and localization in the DC and its subsequent transfer to T cells.

Faculty
Boston University
National Emerging Infectious Disease Lab


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by opiates and HIV Infection
07/15/2020 - 04/30/2025 (Multi-PI)
PI: Suryaram Gummuluru, PhD
NIH/National Institute on Drug Abuse
5R01DA051889-02

Persistent HIV expression induced type 1 IFN responses and inflammaging
08/01/2018 - 04/30/2023 (PI)
NIH/National Institute on Aging
5R01AG060890-04

Signals that establish and maintain HIV latency
05/08/2018 - 04/30/2023 (Subcontract PI)
Boston Medical Center Corporation NIH NIAID
5R01AI138960-03

GM3 Nanoparticles for Sustained Delivery of Anti-Retrovirals to Lymphatic Tissues
11/08/2017 - 10/31/2022 (Multi-PI)
PI: Suryaram Gummuluru, PhD
NIH/National Institute of Allergy & Infectious Diseases
5R01AI132111-04

Mechanism of Cell-Associated HIV-1 Transmission
12/01/2015 - 11/30/2021 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI064099-15

Providence/Boston Center for AIDS Research (CFAR): Core Support (Cores A, B, E, G, K, SWG)
07/01/2018 - 06/30/2021 (PI of Sub-Project / SP)
The Miriam Hospital NIH NIAID
5P30AI042853-22

Engineering a 3D human neurovascular unit for investigating and countering neuroinflammatory mechanisms of HIV
09/30/2017 - 08/31/2020 (Multi-PI)
PI: Suryaram Gummuluru, PhD
NIH/National Institute of Neurological Disorders & Stroke
5R21NS105837-02

CD1a vaginal dendritic cells and HIV-1 acquisition in the female genital tract
05/15/2015 - 04/30/2020 (Subcontract PI)
Boston Medical Center Corporation NIH NIAID
5R01AI122209-05

Lifespan/Tufts/brown Center for AIDS Research (CFAR): Core K, Core B, and Core G
07/01/2016 - 06/30/2018 (PI of Sub-Project / SP)
The Miriam Hospital NIH NIAID
3P30AI042853-19S1

A novel microfluidic system to investigate mechanism of HIV-induced disruption of BBB function
01/01/2017 - 12/31/2017 (Co-Investigator)
The Miriam Hospital NIH NIAID
4P30AI042853-19

Showing 10 of 13 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2021 Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV Infection 5R01DA051889-02
2021 Persistent HIV expression induced type I IFN responses and inflammaging 5R01AG060890-04 2
2021 GM3 Nanoparticles for Sustained Delivery of Anti-Retrovirals to Lymphatic Tissues 5R01AI132111-04 3
2020 Single Cell Transcriptomics of the Opioid Use Disorder and HIV Syndemic in the Human Brain 7UM1DA051411-02
2020 Single cell transcriptomics of the opioid use disorder and HIV syndemic in the human brain 1UM1DA051411-01
2020 Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV Infection 1R01DA051889-01
2020 Persistent HIV expression induced type I IFN responses and inflammaging 5R01AG060890-03 2
2020 GM3 Nanoparticles for Sustained Delivery of Anti-Retrovirals to Lymphatic Tissues 5R01AI132111-03 3
2020 Mechanism of cell-associated HIV-1 transmission 5R01AI064099-15 34
2019 Persistent HIV expression induced type I IFN responses and inflammaging 5R01AG060890-02 2
Showing 10 of 33 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Patten JJ, Keiser PT, Gysi D, Menichetti G, Mori H, Donahue CJ, Gan X, Do Valle I, Geoghegan-Barek K, Anantpadma M, Berrigan JL, Jalloh S, Ayazika T, Wagner F, Zitnik M, Ayehunie S, Anderson D, Loscalzo J, Gummuluru S, Namchuk MN, Barabasi AL, Davey RA. Multidose evaluation of 6,710 drug repurposing library identifies potent SARS-CoV-2 infection inhibitors In Vitro and In Vivo. bioRxiv. 2021 Apr 22.View Related Profiles. PMID: 33907750; PMCID: PMC8077576; DOI: 10.1101/2021.04.20.440626;
     
  2. Yuen RR, Steiner D, Pihl RMF, Chavez E, Olson A, Smith EL, Baird LA, Korkmaz F, Urick P, Sagar M, Berrigan JL, Gummuluru S, Corley RB, Quillen K, Belkina AC, Mostoslavsky G, Rifkin IR, Kataria Y, Cappione AJ, Gao W, Lin NH, Bhadelia N, Snyder-Cappione JE. Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection. Front Immunol. 2021; 12:614676.View Related Profiles. PMID: 33897682; PMCID: PMC8062931; DOI: 10.3389/fimmu.2021.614676;
     
  3. Akiyama H, Jalloh S, Park S, Lei M, Mostoslavsky G, Gummuluru S. Expression of HIV-1 Intron-Containing RNA in Microglia Induces Inflammatory Responses. J Virol. 2020 Dec 09.View Related Profiles. PMID: 33298546; PMCID: PMC8092841; DOI: 10.1128/JVI.01386-20;
     
  4. Eshaghi B, Alsharif N, An X, Akiyama H, Brown KA, Gummuluru S, Reinhard BM. Stiffness of HIV-1 Mimicking Polymer Nanoparticles Modulates Ganglioside-Mediated Cellular Uptake and Trafficking. Adv Sci (Weinh). 2020 Sep; 7(18):2000649.View Related Profiles. PMID: 32999830; PMCID: PMC7509657; DOI: 10.1002/advs.202000649;
     
  5. Akiyama H, Gummuluru S. HIV-1 Persistence and Chronic Induction of Innate Immune Responses in Macrophages. Viruses. 2020 06 30; 12(7).View Related Profiles. PMID: 32630058; PMCID: PMC7412260; DOI: 10.3390/v12070711;
     
  6. Amraie R, Napoleon MA, Yin W, Berrigan J, Suder E, Zhao G, Olejnik J, Gummuluru S, Muhlberger E, Chitalia V, Rahimi N. CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2 and are differentially expressed in lung and kidney epithelial and endothelial cells. bioRxiv. 2020 Jun 23.View Related Profiles. PMID: 32607506; PMCID: PMC7325172; DOI: 10.1101/2020.06.22.165803;
     
  7. Wooten AK, Shenoy AT, Arafa EI, Akiyama H, Martin IMC, Jones MR, Quinton LJ, Gummuluru S, Bai G, Mizgerd JP. Unique Roles for Streptococcus pneumoniae Phosphodiesterase 2 in Cyclic di-AMP Catabolism and Macrophage Responses. Front Immunol. 2020; 11:554.View Related Profiles. PMID: 32300347; PMCID: PMC7145409; DOI: 10.3389/fimmu.2020.00554;
     
  8. Nodder SB, Gummuluru S. Illuminating the Role of Vpr in HIV Infection of Myeloid Cells. Front Immunol. 2019; 10:1606. PMID: 31396206; PMCID: PMC6664105; DOI: 10.3389/fimmu.2019.01606;
     
  9. Gagne M, Michaels D, Schiralli Lester GM, Gummuluru S, Wong WW, Henderson AJ. Strength of T cell signaling regulates HIV-1 replication and establishment of latency. PLoS Pathog. 2019 05; 15(5):e1007802.View Related Profiles. PMID: 31116788; PMCID: PMC6548398; DOI: 10.1371/journal.ppat.1007802;
     
  10. Li M, Waheed AA, Yu J, Zeng C, Chen HY, Zheng YM, Feizpour A, Reinhard BM, Gummuluru S, Lin S, Freed EO, Liu SL. TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5705-5714. PMID: 30842281; PMCID: PMC6431140; DOI: 10.1073/pnas.1819475116;
     
Showing 10 of 53 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 53 publications over 24 distinct years, with a maximum of 6 publications in 2017

YearPublications
19941
19952
19962
19971
19981
19991
20001
20022
20031
20061
20071
20081
20091
20101
20124
20132
20145
20153
20163
20176
20183
20193
20205
20212

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

dendritic cells
glycosphingolipids
HIV pathogenesis
Virological synapse
virus attachment, trafficking, and cell-mediated virus transfer

Available to Mentor as: (Review Mentor Role Definitions):
  • Research / Scholarly Mentor
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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