Nicholas Crossland, DVM, DACVP
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

DVM, Kansas State University
BS, Kansas State University

Pronouns: he/him/his



Dr. Crossland is a board certified Veterinary Anatomic Pathologist. He shares a dual appointment as an Assistant Professor in the Department of Pathology and Laboratory Medicine at Chobanian and Avedisian School of Medicine and an Investigator at the NEIDL where he directs the NEIDL Comparative Pathology Laboratory (NCPL).

His lab aims to elucidate pathogen-host interactions of highly pathogenic microbes. His lab complements classic pathology approaches with cutting edge technologies such as high throughput tissue staining, spatial transcriptomics and quantitative image analysis. This approach enables the discovery of biological pathways driving and preventing disease. At the translational level, we use our expertise to evaluate the efficacy of medical counter measures with the ultimate goal of alleviating and preventing human suffering.

His lab mentors both MS and PhD students that have their sites on pursuing a career in translational research. He is actively exploring collaborative opportunities with other BUMC faculty members to push the outputs achieved from tissue based assays to drive discovery and enhance our understanding of host-pathogen interactions.

Faculty
Boston University
National Emerging Infectious Disease Lab


Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Reverse genetic tools and novel models of henipavirus infection
10/28/2022 - 09/30/2026 (Co-Investigator)
PI: Elke Muhlberger, PhD
Bill and Melinda Gates Foundation


National Emerging Infectious Diseases Laboratories Operations
07/08/2021 - 06/30/2026 (Key Person)
PI: Nancy J. Sullivan, ScD
NIH/National Institute of Allergy & Infectious Diseases
5UC7AI095321-12

Preclinical Models of Infectious Diseases
07/14/2017 - 12/12/2024 (PI)
NIH/National Institute of Allergy & Infectious Diseases


Vectra Polaris Quantitative Pathology Imaging System
09/20/2021 - 09/19/2022 (PI)
NIH/Office of the Director
1S10OD030269-01

Ventana Discovery Ultra Research Autostainer: an Ex+ Core service
08/01/2019 - 07/31/2020 (PI)
NIH/Office of the Director
1S10OD026983-01



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Storm N, Lo M, Crossland N, Seyler-Schmidt M, Staples H, Silva-Ayala D, Laprise AM, St Denis L, Grosz K, O'Connell A, Gertje H, Ripin T, Decker C, Mazur M, Thurman C, Espinoza M, Morrow G, Parks CL, Cooper CL, Griffiths A. An Intranasal Challenge Model in African Green Monkeys (Chlorocebus aethiops) for Mild-to-Moderate COVID-19 Disease Caused by Subvariant XBB.1.5. Viruses. 2025 Oct 14; 17(10).View Related Profiles. PMID: 41157643; PMCID: PMC12568310; DOI: 10.3390/v17101373;
     
  2. Yabaji SM, Lata S, Tseng AE, Araveti PB, Lo M, Gavrish I, O'Connell AK, Gertje HP, Belkina AC, Thurman CE, Kiyokawa H, Kotton D, Tan S, Endsley JJ, Bishai WR, Crossland N, Kobzik L, Kramnik I. Dysplastic lung repair fosters a tuberculosis-promoting microenvironment through maladaptive macrophage polarization. PLoS Pathog. 2025 Oct; 21(10):e1013563.View Related Profiles. PMID: 41052208; PMCID: PMC12510645; DOI: 10.1371/journal.ppat.1013563;
     
  3. Yabaji SM, Zhernovkov V, Araveti PB, Lata S, Rukhlenko OS, Abdullatif SA, Vanvalkenburg A, Alekseyev YO, Ma Q, Dayama G, Lau NC, Johnson WE, Bishai WR, Crossland NA, Campbell JD, Kholodenko BN, Gimelbrant AA, Kobzik L, Kramnik I. Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility. Elife. 2025 Oct 02; 14.View Related Profiles. PMID: 41037321; PMCID: PMC12490860; DOI: 10.7554/eLife.106814;
     
  4. Lam LKM, Gilliland T, Dunn M, Alcorn-Burckhardt MD, Terada Y, Sun C, Vasilatos S, Midgett M, Williams C, Laughlin A, Lundy J, Gardner CL, Thomas A, Raué HP, Gertje HP, O'Connell AK, Crossland NA, Reed DS, Diamond MS, Slifka MK, Klimstra WB. An inactivated trivalent virion-based vaccine protects against aerosol challenge with encephalitic alphaviruses in mice and macaques. Sci Transl Med. 2025 Oct; 17(818):eadv7079. PMID: 41032627; DOI: 10.1126/scitranslmed.adv7079;
     
  5. Schwoerer MP, Carver S, Lin AE, Liu J, Cafiero TR, Berggren KA, Dhawan S, Suzuki S, Heller B, Rodriguez C, O'Connell AK, Gertje HP, Crossland NA, Ploss A. Receptor transporter protein 4 (RTP4)-mediated repression of hepatitis C virus replication in mouse cells. PLoS Pathog. 2025 Sep; 21(9):e1013412. PMID: 40920810; PMCID: PMC12431671; DOI: 10.1371/journal.ppat.1013412;
     
  6. Kenney D, O'Connell AK, Tseng AE, Turcinovic J, Sheehan ML, Nitido AD, Montanaro P, Gertje HP, Ericsson M, Connor JH, Vrbanac V, Crossland NA, Harly C, Balazs AB, Douam F. Immune signatures of SARS-CoV-2 infection resolution in human lung tissues. PLoS Pathog. 2025 Sep; 21(9):e1013469.View Related Profiles. PMID: 40920821; PMCID: PMC12425302; DOI: 10.1371/journal.ppat.1013469;
     
  7. Schwoerer MP, Carver S, Cafiero TR, Joyce B, Berggren KA, Suzuki S, Heller B, O'Connell AK, Gertje HP, Crossland NA, Posfai E, Ploss A. Assessment of hepatitis C virus permissiveness in iteratively genetically humanized mice. J Virol. 2025 Sep 23; 99(9):e0079325. PMID: 40899815; PMCID: PMC12456128; DOI: 10.1128/jvi.00793-25;
     
  8. Tseng AE, O'Connell A, Benhamou A, Yabaji S, Kramnik I, Crossland NA, Speranza E. Iterative Bleaching Extends Multiplicity with Use of Staining Automation for Core Facilities. J Vis Exp. 2025 Aug 06; (222).View Related Profiles. PMID: 40853880
     
  9. Yabaji SM, Lata S, Gavrish I, Lo M, O'Connell AK, Gertje HP, Thurman CE, Crossland NA, Kobzik L, Kramnik I. Protocol for developing a mouse model of post-primary pulmonary tuberculosis after hematogenous spread in native lungs and lung implants. STAR Protoc. 2025 Sep 19; 6(3):103984.View Related Profiles. PMID: 40714561; PMCID: PMC12311599; DOI: 10.1016/j.xpro.2025.103984;
     
  10. Zhang J, Chavez EC, Winkler M, Liu J, Carver S, Lin AE, Biswas A, Tamura T, Tseng A, Wang D, Benhamou A, O' Connell AK, Matsuo M, Norton JE, Kenney D, Adamson B, Kleiner RE, Burwitz B, Crossland NA, Douam F, Ploss A. Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccine. Nat Microbiol. 2025 Aug; 10(8):1902-1917.View Related Profiles. PMID: 40629111; PMCID: PMC12313524; DOI: 10.1038/s41564-025-02047-y;
     
Showing 10 of 73 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 73 publications over 11 distinct years, with a maximum of 20 publications in 2025

YearPublications
20111
20151
20162
20172
20185
20204
20218
20229
202311
202410
202520


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BU Today 9/27/2022
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Immunohistochemistry
In Situ Hybridization
Histopathology
Emerging Infectious Diseases
Animal Models, Experimental
Image Analysis, Computer-Assisted
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