Nicholas Crossland, DVM, DACVP
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

DVM, Kansas State University
BS, Kansas State University

Pronouns: he/him/his



Dr. Crossland is a board certified Veterinary Anatomic Pathologist. He shares a dual appointment as an Assistant Professor in the Department of Pathology and Laboratory Medicine at Chobanian and Avedisian School of Medicine and an Investigator at the NEIDL where he directs the NEIDL Comparative Pathology Laboratory (NCPL).

His lab aims to elucidate pathogen-host interactions of highly pathogenic microbes. His lab complements classic pathology approaches with cutting edge technologies such as high throughput tissue staining, spatial transcriptomics and quantitative image analysis. This approach enables the discovery of biological pathways driving and preventing disease. At the translational level, we use our expertise to evaluate the efficacy of medical counter measures with the ultimate goal of alleviating and preventing human suffering.

His lab mentors both MS and PhD students that have their sites on pursuing a career in translational research. He is actively exploring collaborative opportunities with other BUMC faculty members to push the outputs achieved from tissue based assays to drive discovery and enhance our understanding of host-pathogen interactions.

Faculty
Boston University
National Emerging Infectious Disease Lab


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




National Emerging Infectious Diseases Laboratories Operations
07/08/2021 - 06/30/2026 (Key Person)
PI: Nancy J. Sullivan, ScD
NIH/National Institute of Allergy & Infectious Diseases
5UC7AI095321-09

Reverse genetic tools and novel models of henipavirus infection
10/28/2022 - 09/30/2025 (Co-Investigator)
PI: Elke Muhlberger, PhD
Bill and Melinda Gates Foundation


Preclinical Models of Infectious Diseases
07/14/2017 - 07/13/2024 (PI)
NIH/National Institute of Allergy & Infectious Diseases


Vectra Polaris Quantitative Pathology Imaging System
09/20/2021 - 09/19/2022 (PI)
NIH/Office of the Director
1S10OD030269-01

Ventana Discovery Ultra Research Autostainer: an Ex+ Core service
08/01/2019 - 07/31/2020 (PI)
NIH/Office of the Director
1S10OD026983-01



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Chen DY, Turcinovic J, Feng S, Kenney DJ, Chin CV, Choudhary MC, Conway HL, Semaan M, Close BJ, Tavares AH, Seitz S, Khan N, Kapell S, Crossland NA, Li JZ, Douam F, Baker SC, Connor JH, Saeed M. Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus. iScience. 2023 May 19; 26(5):106634.View Related Profiles. PMID: 37095858; PMCID: PMC10083141; DOI: 10.1016/j.isci.2023.106634;
     
  2. Thieulent CJ, Dittmar W, Balasuriya UBR, Crossland NA, Wen X, Richt JA, Carossino M. Mouse-Adapted SARS-CoV-2 MA10 Strain Displays Differential Pulmonary Tropism and Accelerated Viral Replication, Neurodissemination, and Pulmonary Host Responses in K18-hACE2 Mice. mSphere. 2023 Feb 21; 8(1):e0055822. PMID: 36728430; PMCID: PMC9942576; DOI: 10.1128/msphere.00558-22;
     
  3. Browning JL, Bhawan J, Tseng A, Crossland N, Bujor AM, Akassoglou K, Assassi S, Skaug B, Ho J. Extensive and Persistent Extravascular Dermal Fibrin Deposition Characterizes Systemic Sclerosis. bioRxiv. 2023 Jan 19.View Related Profiles. PMID: 36711912; PMCID: PMC9882194; DOI: 10.1101/2023.01.16.523256;
     
  4. Chen DY, Chin CV, Kenney D, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Adams S, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M. Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation. Nature. 2023 Mar; 615(7950):143-150.View Related Profiles. PMID: 36630998
     
  5. Chen DY, Kenney D, Chin CV, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M. Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron. bioRxiv. 2023 Jan 10.View Related Profiles. PMID: 36263066; PMCID: PMC9580375; DOI: 10.1101/2022.10.13.512134;
     
  6. Kehrer T, Cupic A, Ye C, Yildiz S, Bouhhadou M, Crossland NA, Barrall E, Cohen P, Tseng A, Çagatay T, Rathnasinghe R, Flores D, Jangra S, Alam F, Mena N, Aslam S, Saqi A, Marin A, Rutkowska M, Ummadi MR, Pisanelli G, Richardson RB, Veit EC, Fabius JM, Soucheray M, Polacco BJ, Evans MJ, Swaney DL, Gonzalez-Reiche AS, Sordillo EM, van Bakel H, Simon V, Zuliani-Alvarez L, Fontoura BMA, Rosenberg BR, Krogan NJ, Martinez-Sobrido L, García-Sastre A, Miorin L. Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis. bioRxiv. 2022 Nov 30. PMID: 36299428; PMCID: PMC9603824; DOI: 10.1101/2022.10.18.512708;
     
  7. Nambulli S, Rennick LJ, Acciardo AS, Tilston-Lunel NL, Ho G, Crossland NA, Hardcastle K, Nieto B, Bainbridge G, Williams T, Sharp CR, Duprex WP. FeMV is a cathepsin-dependent unique morbillivirus infecting the kidneys of domestic cats. Proc Natl Acad Sci U S A. 2022 Oct 25; 119(43):e2209405119.View Related Profiles. PMID: 36251995; PMCID: PMC9618091; DOI: 10.1073/pnas.2209405119;
     
  8. Liu Y, Park D, Cafiero TR, Bram Y, Chandar V, Tseng A, Gertje HP, Crossland NA, Su L, Schwartz RE, Ploss A. Molecular clones of genetically distinct hepatitis B virus genotypes reveal distinct host and drug treatment responses. JHEP Rep. 2022 Sep; 4(9):100535. PMID: 36035359; PMCID: PMC9403497; DOI: 10.1016/j.jhepr.2022.100535;
     
  9. Wei L, Cafiero TR, Tseng A, Gertje HP, Berneshawi A, Crossland NA, Ploss A. Conversion of hepatitis B virus relaxed circular to covalently closed circular DNA is supported in murine cells. JHEP Rep. 2022 Sep; 4(9):100534. PMID: 36035363; PMCID: PMC9403495; DOI: 10.1016/j.jhepr.2022.100534;
     
  10. Rosenbloom R, Gavrish I, Tseng AE, Seidel K, Yabaji SM, Gertje HP, Huber BR, Kramnik I, Crossland NA. Progression and Dissemination of Pulmonary Mycobacterium Avium Infection in a Susceptible Immunocompetent Mouse Model. Int J Mol Sci. 2022 May 26; 23(11).View Related Profiles. PMID: 35682679; PMCID: PMC9181083; DOI: 10.3390/ijms23115999;
     
Showing 10 of 37 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 37 publications over 9 distinct years, with a maximum of 9 publications in 2022

YearPublications
20111
20151
20162
20172
20185
20204
20218
20229
20235


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In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Immunohistochemistry
In Situ Hybridization
Histopathology
Emerging Infectious Diseases
Animal Models, Experimental
Image Analysis, Computer-Assisted
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