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PhD, Justus Liebig Universitaet Giessen
BPharm, Tamil Nadu Dr. M.G.R. Medical University

Pronouns: he/him/his

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ORCID : 0000-0002-0194-5044

BU Research

Anti-complement therapy: a drug target for COVID-19-induced inflammation and coagulation
03/01/2021 - 02/28/2022 (PI)
Aniara Diagnostica

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Subramaniam S, Kothari H, Bosmann M. Tissue factor in COVID-19-associated coagulopathy. Thromb Res. 2022 Dec; 220:35-47.View Related Profiles.

Bosmann, Markus
Subramaniam, Saravanan

PMID: 36265412; PMCID: PMC9525243; DOI: 10.1016/j.thromres.2022.09.025;

Subramaniam S, Liu J, Fletcher C, Ramchandran R, Weiler H. Coagulation Factor IIIa (f3a) Knockdown in Zebrafish Leads to Defective Angiogenesis and Mild Bleeding Phenotype. Front Cell Dev Biol. 2022; 10:852989. PMID: 35386206; PMCID: PMC8978257; DOI: 10.3389/fcell.2022.852989;

Carossino M, Kenney D, O'Connell AK, Montanaro P, Tseng AE, Gertje HP, Grosz KA, Ericsson M, Huber BR, Kurnick SA, Subramaniam S, Kirkland TA, Walker JR, Francis KP, Klose AD, Paragas N, Bosmann M, Saeed M, Balasuriya UBR, Douam F, Crossland NA. Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression. Viruses. 2022 03 05; 14(3).View Related Profiles.

Huber, Bertrand
Douam, Florian
Bosmann, Markus
Saeed, Mohsan
Crossland, Nicholas
Subramaniam, Saravanan

PMID: 35336942; PMCID: PMC8955233; DOI: 10.3390/v14030535;

Eaton N, Subramaniam S, Schulte ML, Drew C, Jakab D, Haberichter SL, Weiler H, Falet H. Bleeding diathesis in mice lacking JAK2 in platelets. Blood Adv. 2021 08 10; 5(15):2969-2981. PMID: 34342643; PMCID: PMC8361459; DOI: 10.1182/bloodadvances.2020003032;

Subramaniam S, Ogoti Y, Hernandez I, Zogg M, Botros F, Burns R, DeRousse JT, Dockendorff C, Mackman N, Antoniak S, Fletcher C, Weiler H. A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C). Blood Adv. 2021 07 13; 5(13):2760-2774. PMID: 34242391; PMCID: PMC8288670; DOI: 10.1182/bloodadvances.2021004360;

Subramaniam S, Ruf W, Bosmann M. Advocacy of targeting protease-activated receptors in severe coronavirus disease 2019. Br J Pharmacol. 2022 May; 179(10):2086-2099.View Related Profiles.

Bosmann, Markus
Subramaniam, Saravanan

PMID: 34235728; PMCID: PMC8794588; DOI: 10.1111/bph.15587;

Carossino M, Montanaro P, O'Connell A, Kenney D, Gertje H, Grosz KA, Kurnick SA, Bosmann M, Saeed M, Balasuriya UBR, Douam F, Crossland NA. Fatal neuroinvasion of SARS-CoV-2 in K18-hACE2 mice is partially dependent on hACE2 expression. bioRxiv. 2021 Jan 15.View Related Profiles.

Huber, Bertrand
Douam, Florian
Bosmann, Markus
Saeed, Mohsan
Crossland, Nicholas
Subramaniam, Saravanan

PMID: 33469581; PMCID: PMC7814818; DOI: 10.1101/2021.01.13.425144;

Kiouptsi K, Jäckel S, Pontarollo G, Grill A, Kuijpers MJE, Wilms E, Weber C, Sommer F, Nagy M, Neideck C, Jansen Y, Ascher S, Formes H, Karwot C, Bayer F, Kollar B, Subramaniam S, Molitor M, Wenzel P, Rosenstiel P, Todorov H, Gerber S, Walter U, Jurk K, Heemskerk JWM, van der Vorst EPC, Döring Y, Reinhardt C. The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice. mBio. 2019 10 22; 10(5). PMID: 31641089; PMCID: PMC6805995; DOI: 10.1128/mBio.02298-19;

Subramaniam S, Boukhlouf S, Fletcher C. A bacterial metabolite, trimethylamine N-oxide, disrupts the hemostasis balance in human primary endothelial cells but no coagulopathy in mice. Blood Coagul Fibrinolysis. 2019 Oct; 30(7):324-330. PMID: 31490208; DOI: 10.1097/MBC.0000000000000838;

Gao C, Schroeder JA, Xue F, Jing W, Cai Y, Scheck A, Subramaniam S, Rao S, Weiler H, Czechowicz A, Shi Q. Nongenotoxic antibody-drug conjugate conditioning enables safe and effective platelet gene therapy of hemophilia A mice. Blood Adv. 2019 09 24; 3(18):2700-2711. PMID: 31515232; PMCID: PMC6759737; DOI: 10.1182/bloodadvances.2019000516;

Showing 10 of 27 results. Show More

Gandhi DM, Rosas R, Greve E, Kentala K, D-R Diby N, Snyder VA, Stephans A, Yeung THW, Subramaniam S, DiMilo E, Kurtenbach KE, Arnold LA, Weiler H, Dockendorff C. The parmodulin NRD-21 is an allosteric inhibitor of PAR1 Gq signaling with improved anti-inflammatory activity and stability. Bioorg Med Chem. 2019 09 01; 27(17):3788-3796. PMID: 31320211; PMCID: PMC6706283; DOI: 10.1016/j.bmc.2019.06.043;

Subramaniam S, Kanse SM, Kothari H, Reinhardt C, Fletcher C. Post-transcriptional, post-translational and pharmacological regulation of tissue factor pathway inhibitor. Blood Coagul Fibrinolysis. 2018 Dec; 29(8):668-682. PMID: 30439766

Etscheid M, Subramaniam S, Lochnit G, Zabczyk M, Undas A, Lang IM, Hanschmann KM, Kanse SM. Altered structure and function of fibrinogen after cleavage by Factor VII Activating Protease (FSAP). Biochim Biophys Acta Mol Basis Dis. 2018 10; 1864(10):3397-3406. PMID: 30076961; DOI: 10.1016/j.bbadis.2018.07.030;

Bode MF, Auriemma AC, Grover SP, Hisada Y, Rennie A, Bode WD, Vora R, Subramaniam S, Cooley B, Andrade-Gordon P, Antoniak S, Mackman N. The factor Xa inhibitor rivaroxaban reduces cardiac dysfunction in a mouse model of myocardial infarction. Thromb Res. 2018 07; 167:128-134. PMID: 29843086

Subramaniam S, Scharrer I. Procoagulant activity during viral infections. Front Biosci (Landmark Ed). 2018 Jan 01; 23:1060-1081. PMID: 28930589; DOI: 10.2741/4633;

Subramaniam S, Fletcher C. Trimethylamine N-oxide: breathe new life. Br J Pharmacol. 2018 04; 175(8):1344-1353. PMID: 28745401; PMCID: PMC5866995; DOI: 10.1111/bph.13959;

Kiouptsi K, Grill A, Mann A, Döhrmann M, Lillich M, Jäckel S, Malinarich F, Formes H, Manukyan D, Subramaniam S, Khandagale A, Karwot C, Thal SC, Bosmann M, Scharrer I, Jurk K, Reinhardt C. Mice deficient in the anti-haemophilic coagulation factor VIII show increased von Willebrand factor plasma levels. PLoS One. 2017; 12(8):e0183590.View Related Profiles.

Bosmann, Markus
Subramaniam, Saravanan

PMID: 28837614; PMCID: PMC5570278; DOI: 10.1371/journal.pone.0183590;

Herold J, Nowak S, Kostin S, Daniel JM, Francke A, Subramaniam S, Braun-Dullaeus RC, Kanse SM. Factor VII activating protease (FSAP) influences vascular remodeling in the mouse hind limb ischemia model. Am J Transl Res. 2017; 9(6):3084-3095. PMID: 28670395; PMCID: PMC5489907

Jäckel S, Kiouptsi K, Lillich M, Hendrikx T, Khandagale A, Kollar B, Hörmann N, Reiss C, Subramaniam S, Wilms E, Ebner K, Brühl MV, Rausch P, Baines JF, Haberichter S, Lämmle B, Binder CJ, Jurk K, Ruggeri ZM, Massberg S, Walter U, Ruf W, Reinhardt C. Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2. Blood. 2017 07 27; 130(4):542-553. PMID: 28572286; DOI: 10.1182/blood-2016-11-754416;

Subramaniam S, Jurk K, Hobohm L, Jäckel S, Saffarzadeh M, Schwierczek K, Wenzel P, Langer F, Reinhardt C, Ruf W. Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development. Blood. 2017 04 20; 129(16):2291-2302. PMID: 28223279; PMCID: PMC5399485; DOI: 10.1182/blood-2016-11-749879;

Busch CJ, Hendrikx T, Weismann D, Jäckel S, Walenbergh SM, Rendeiro AF, Weißer J, Puhm F, Hladik A, Göderle L, Papac-Milicevic N, Haas G, Millischer V, Subramaniam S, Knapp S, Bennett KL, Bock C, Reinhardt C, Shiri-Sverdlov R, Binder CJ. Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice. Hepatology. 2017 04; 65(4):1181-1195. PMID: 27981604; PMCID: PMC5892702; DOI: 10.1002/hep.28970;

Tatsumi K, Antoniak S, Subramaniam S, Gondouin B, Neidich SD, Beck MA, Mickelson J, Monroe DM, Bastarache JA, Mackman N. Anticoagulation increases alveolar hemorrhage in mice infected with influenza A. Physiol Rep. 2016 12; 4(24). PMID: 28003564; PMCID: PMC5210384; DOI: 10.14814/phy2.13071;

Luther N, Shahneh F, Brähler M, Krebs F, Jäckel S, Subramaniam S, Stanger C, Schönfelder T, Kleis-Fischer B, Reinhardt C, Probst HC, Wenzel P, Schäfer K, Becker C. Innate Effector-Memory T-Cell Activation Regulates Post-Thrombotic Vein Wall Inflammation and Thrombus Resolution. Circ Res. 2016 Dec 09; 119(12):1286-1295. PMID: 27707800; DOI: 10.1161/CIRCRESAHA.116.309301;

Subramaniam S, Kanse SM. Ferric chloride-induced arterial thrombosis in mice. Curr Protoc Mouse Biol. 2014 Dec 11; 4(4):151-64. PMID: 25723183

Subramaniam S, Thielmann I, Morowski M, Pragst I, Sandset PM, Nieswandt B, Etscheid M, Kanse SM. Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP). Thromb Haemost. 2015 Apr; 113(4):870-80. PMID: 25427855; DOI: 10.1160/TH14-06-0519;

Subramaniam S, Ramachandran S, Uthrapathi S, Gnamanickam VR, Dubey GP. Anti-hyperlipidemic and antioxidant potential of different fractions of Terminalia arjuna Roxb. bark against PX- 407 induced hyperlipidemia. Indian J Exp Biol. 2011 Apr; 49(4):282-8. PMID: 21614892

Subramaniam S, Subramaniam R, Rajapandian S, Uthrapathi S, Gnanamanickam VR, Dubey GP. Anti-Atherogenic Activity of Ethanolic Fraction of Terminalia arjuna Bark on Hypercholesterolemic Rabbits. Evid Based Complement Alternat Med. 2011; 2011:487916. PMID: 21785628; PMCID: PMC3136348; DOI: 10.1093/ecam/neq003;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

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