Allen Caobi, PhD
Postdoctoral Fellow
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology

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I am a Postdoctoral Associate in the laboratory of Dr. Mohsan Saeed, at Boston University’s National Emerging Infectious Diseases Laboratory (NEIDL). I completed my PhD in Biomedical Science at Florida International University, in Miami, Florida. My PhD research focused on three primary aims: 1) Establishing a genomic and proteomic profile of exosomes derived from HIV-infected PBMCs in the context of opiate abuse, with the intention to then observe the effects of these PBMC-derived exosomes on primary neuronal cell function. 2) Development of a nanotherapeutic to ameliorate HIV-associated neuropathology by delivering an exosome containing the desired therapeutic agent (Truvada) and magnetic nano-particles (MNPs) across the blood-brain barrier (BBB). 3) Lastly, I developed an exosome-derived protein biomarker profile to assess neurocognitive impairment (NCI) if people living with HIV or AIDS (PLWHA).

I entered the Saeed Lab in June, 2022. My current research explores the role of viral pathogenicity factors in disease mechanisms. I am particularly focusing on coronaviruses and enteroviruses, both of which encode a number of proteins that modulate host antiviral defenses and create a suitable environment for virus replication. I use various molecular virology approaches to uncover the ways in which these proteins ablate host immunity and contribute to disease development.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Caobi A, Saeed M. Upping the ante: enhanced expression of interferon-antagonizing ORF6 and ORF9b proteins by SARS-CoV-2 variants of concern. Curr Opin Microbiol. 2024 Mar 21; 79:102454.View Related Profiles. PMID: 38518551
     
  2. Andre M, Caobi A, Miles JS, Vashist A, Ruiz MA, Raymond AD. Diagnostic potential of exosomal extracellular vesicles in oncology. BMC Cancer. 2024 Mar 08; 24(1):322. PMID: 38454346; PMCID: PMC10921614; DOI: 10.1186/s12885-024-11819-4;
     
  3. Caobi A, Bonilla J, Gomez M, Andre M, Yndart A, Fernandez-Lima FA, Nair MP, Raymond AD. HIV-1 and opiates modulate miRNA profiles in extracellular vesicles. Front Immunol. 2023; 14:1259998. PMID: 38022533; PMCID: PMC10666642; DOI: 10.3389/fimmu.2023.1259998;
     
  4. Caobi A, Werne R, Gomez M, Andre M, Thomas C, Lima-Hernandez F, Nair M, Raymond AD. Protein cargo of Nef-containing exosomal extracellular vesicles may predict HIV-associated Neurocognitive Impairment status. Res Sq. 2023 Jun 23. PMID: 37214960; PMCID: PMC10197801; DOI: 10.21203/rs.3.rs-2740135/v2;
     
  5. Esteban-Lopez M, Perry MD, Garbinski LD, Manevski M, Andre M, Ceyhan Y, Caobi A, Paul P, Lau LS, Ramelow J, Owens F, Souchak J, Ales E, El-Hage N. Health effects and known pathology associated with the use of E-cigarettes. Toxicol Rep. 2022; 9:1357-1368. PMID: 36561957; PMCID: PMC9764206; DOI: 10.1016/j.toxrep.2022.06.006;
     
  6. Caobi A, Nair M, Raymond AD. Extracellular Vesicles in the Pathogenesis of Viral Infections in Humans. Viruses. 2020 10 21; 12(10). PMID: 33096825; PMCID: PMC7589806; DOI: 10.3390/v12101200;
     
  7. Caobi A, Dutta RK, Garbinski LD, Esteban-Lopez M, Ceyhan Y, Andre M, Manevski M, Ojha CR, Lapierre J, Tiwari S, Parira T, El-Hage N. The Impact of CRISPR-Cas9 on Age-related Disorders: From Pathology to Therapy. Aging Dis. 2020 Jul; 11(4):895-915. PMID: 32765953; PMCID: PMC7390517; DOI: 10.14336/AD.2019.0927;
     
  8. Gonzalez BA, Perez-Nevarez M, Mirza A, Perez MG, Lin YM, Hsu CD, Caobi A, Raymond A, Gomez Hernandez ME, Fernandez-Lima F, George F, Ramaswamy S. Physiologically Relevant Fluid-Induced Oscillatory Shear Stress Stimulation of Mesenchymal Stem Cells Enhances the Engineered Valve Matrix Phenotype. Front Cardiovasc Med. 2020; 7:69. PMID: 32509802; PMCID: PMC7248568; DOI: 10.3389/fcvm.2020.00069;
     
  9. Miles J, Andre M, Caobi A, Ruiz M, Nair M, Raymond AD. Bioengineered Exosomal Extracellular Vesicles in Cancer Therapeutics. Crit Rev Biomed Eng. 2020; 48(3):177-187. PMID: 33389895
     
  10. Caobi A, Andre M, Miles J, Tomitaka A, Nikkhah-Moshaie R, Hernandez A, Nair M, Raymond AD. Magnetic Nanoparticle and Exosomal Therapeutic (M-NEXT) Effects on HIV-Associated Neurotoxicity. Crit Rev Biomed Eng. 2020; 48(3):189-198. PMID: 33389896
     
Showing 10 of 12 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 12 publications over 6 distinct years, with a maximum of 5 publications in 2020

YearPublications
20181
20191
20205
20221
20232
20242

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