George J. Murphy, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Dept of Medicine
Hematology & Medical Oncology

PhD, University of Oxford



I have developed an approach to science that utilizes multiple stem cell-based platforms to answer basic biological questions and combat human disease. My current research portfolio is a direct reflection of my evolution as a scientist in which my early studies of hematopoietic development led to the generation of useful tools and reagents as well as methodologies and insights that synergized into a potent platform in the emerging and rapidly expanding field of pluripotent stem cell biology. My group is composed of dynamic and passionate young researchers and together we have impacted the following areas of investigation:

1.) Developmental hematopoiesis
2.) The generation, culture, and directed differentiation of pluripotent stem cells
3.) Pluripotent stem cell-based modeling of hematopoiesis: a Platform for Production of Transfusable Human Blood Cells
4.) Pluripotent Stem Cell Modeling of Human Disease: The ‘Clinical Trial in a Test Tube’: Sickle Cell Anemia; Amyloidosis

Diversity, Equity, Inclusion and Accessibility

As a first generation student, the product of a broken home in a low resource setting, and someone fortunate enough to have overcome many barriers on the path to a career in academia, I am deeply committed to diversity, equity and inclusion efforts to broaden the spectrum of those able to access a career in science and medicine.

Mentorship As a Driver of DEI:
My success as an independent investigator in an extraordinarily competitive branch of science is the direct result of the thoughtful and effective mentorship I have received throughout my career. As such, I understand the critical importance of mentorship, and it has been the foundation upon which I built my lab and surrounding Center for Regenerative Medicine (CReM), the emphasis point in my role as the Director of Research in my Division, and is central to my philosophy in training the next great diverse generation of scientists and clinicians. In accordance with my belief that diverse teams are more impactful and productive, my past trainees have included an individual from a nomadic family in Africa who had been greatly impacted by the HIV epidemic, a refugee from Myanmar (Burma), as well as many first generation students from modest backgrounds…all who have gone on to achieve tremendous success and become exceptional mentors themselves.

A Focus on Diseases That Directly Impact our Surrounding, Underserved Community:
At the CReM, we focus on diseases that directly impact our surrounding underserved community, as one of our main charges is to bring cutting edge, transformative research to the masses. In essence, we like to think that we perform ‘research with reach’ that we hope has the ability to one day transform the lives of all patients here at Boston Medical Center (BMC) and the world, regardless of race, gender, sexual orientation or socio-economic status. One of our goals is to revolutionize the care of patients living with Sickle Cell Disease (SCD), and to one day completely cure the disorder. But there are tremendous health disparities surrounding SCD—although it’s the most common genetic disease worldwide, research has been chronically underfunded, in part due to systemic racism. As a countermeasure, BMC has pulled together a group of world experts in the field, and we all share the vision of better patient care and eventually, a world without sickle cell disease. That mission – that mindset – is unique and gets right to the heart of health equity; Our goal is to remove healthcare obstacles and to give every person the chance to live their healthiest, fullest life. Lastly, although there are very exciting, emerging therapies that may make this possible, a personal charge for myself is also to ensure that these emerging, potentially transformative therapies will be accessible to all: https://www.ted.com/talks/george_murphy_miracle_cures_won_t_answer_your_prayers_if_you_re_poor

Equity and Inclusion Efforts During the COVID-19 Pandemic:
At the height of the pandemic, when rates of infection were skyrocketing, when everything was shut down including most academic centers, when it was virtually impossible to get a COVID test in an appreciable time frame in order to make critical care decisions and isolate those that were infected, I led a Team that mobilized and repurposed ourselves and our center, to build our own FDA approved COVID test, from easily sourced materials that could be found in any lab, in 7 days with a testing turn around time of less than 24 hours. And in true BMC fashion, as soon as we accomplished this, we immediately began to share this information, this ‘blueprint’ for how to run the test, throughout Boston and around the World. As a safety net hospital, our underserved patient population often goes without access to state-of-the-art clinical trials and in this case, rapid COVID testing. This initiative was one of the first of its kind in the country and allowed all of our patients, regardless of socio-economic status, to access rapidly emerging technology leading to more effective care for COVID's most vulnerable victims:
Vanuytsel K, Mithal A, Giadone RM, Yeung AK, Matte TM, Dowrey TW, Werder RB, Miller GJ, Miller NS, Andry CD, Murphy GJ. (2020) Rapid implementation of a SARS-CoV-2 diagnostic quantitative real-time PCR test with emergency use authorization at a large academic safety net hospital. Med Cell Press.

Other Efforts:
Anti-Racism Committee, Center for Regenerative Medicine (CReM), BUSM
Anti-Racism Steering Committee, Division of Hematology-Oncology, BUSM

Member
Boston University
Pulmonary Center


Co-Director
Boston University
Center for Regenerative Medicine


Member
Boston University
Center of Excellence in Sickle Cell Disease


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Boston Medical Center


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences


Member
Boston University
Genome Science Institute




Understanding the Symbiosis Between Megakaryocytes and the Lung Microenvironment
09/01/2020 - 08/31/2024 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute
5F30HL154552-03

Understanding the impact of group 2 innate lymphoid cells on airway epithelial regeneration and repair
04/01/2022 - 03/31/2024 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute
1F31HL162493-01

2021 ASH Hematology Opportunities for the Next-Generation of Research Scientists (HONORS) Award
07/01/2021 - 06/30/2022 (Key Person / Mentor)
American Society of Hematology


Defining the role of the AHR in Blood Cell Specification
01/01/2016 - 11/30/2021 (Multi-PI)
PI: George J. Murphy, PhD
NIH/National Institute of Environmental Health Sciences
5R01ES025409-05

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2017 (Multi-PI)
PI: George J. Murphy, PhD
NIH/National Heart, Lung, and Blood Institute
5U01HL107443-05

Stress Granules and the Biology of TDP-43
01/01/2016 - 12/31/2016 (Multi-PI)
PI: George J. Murphy, PhD
NIH/National Institute of Environmental Health Sciences
4R01ES020395-05

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2016 (Co-Investigator)
PI: Martin H. Steinberg, MD
NIH/National Heart, Lung, and Blood Institute
1U01HL107443-01

Stress Granules and the Biology of TDP-43
03/01/2012 - 12/31/2015 (Co-Investigator)
PI: Benjamin Wolozin, MD, PhD
NIH/National Institute of Environmental Health Sciences
5R01ES020395-04

Boston University Clinical and Translational Science Award (CTSA) Program UL1
05/01/2008 - 04/30/2013 (PI of Sub-Project / SP)
PI: David M. Center, MD
NIH/National Center for Health Research Resources
3UL1RR025771-04


Understanding Hepatic Proteostasis in Systemic Amyloid Diseases
07/14/2020 - 03/31/2023 (PI)
Scripps Research Institute National Institutes

Identifying protective omics profiles in centenarians and translating these int…
09/15/2019 - 04/30/2022 (PI)
Trustees of Boston University NIH-NIA
5UH2AG064704-02

Mechanisms of cis-acting HbF regulation in sickle cell anemia
04/01/2017 - 03/31/2022 (PI)
NIH-NHLBI
5R01HL133350-03

Large scale, cost-efficient screening and detection of SARS-
05/01/2020 - 12/31/2021 (PI)
Harvard Medical School MLSC

Defining the role of the AHR in Blood Cell Specification
01/01/2016 - 11/30/2021 (PI)
Trustees of Boston University NIH-NIEHS

iPSC-based Modeling and Therapeutic Intervention In Sickle Cell Disease
09/23/2019 - 09/22/2020 (PI)
Beam Therapeutics

Megakaryocyte Transcription Factor Activation to Enhance In Vitro Platelet Production from Humans IP
09/10/2015 - 05/31/2019 (PI)
Children's Hospital NIH-NHLBI
5R01HL130793-04

Targeting Endogenous Signaling Pathways to Amliorate Systemic Amyloidoses
09/08/2014 - 06/30/2018 (PI)
The Scripps Research Institute NIH-NIDDK

iPSC-based Modeling and Therapeutic Intervention in Sickle Cell Disease
12/15/2016 - 12/14/2017 (PI)
Incyte Corporation

Globin Gene Expression in Sickle Cell Genotype-Specific iPS Cells
07/05/2011 - 06/30/2017 (PI)
Trustees of Boston University NIH-NHLBI

Showing 10 of 14 results. Show All Results

Title


Yr Title Project-Sub Proj Pubs
2022 UNDERSTANDING HEPATIC PROTEOSTASIS IN SYSTEMIC AMYLOID DISEASES 5R01DK123038-03
2021 UNDERSTANDING HEPATIC PROTEOSTASIS IN SYSTEMIC AMYLOID DISEASES 5R01DK123038-02
2020 UNDERSTANDING HEPATIC PROTEOSTASIS IN SYSTEMIC AMYLOID DISEASES 1R01DK123038-01A1
2020 Mechanisms of cis-acting HbF regulation in sickle cell anemia 5R01HL133350-04 11
2020 Defining the Role of the AHR in Blood Cell Specifications 5R01ES025409-05 4
2019 Mechanisms of cis-acting HbF regulation in sickle cell anemia 5R01HL133350-03 11
2019 Defining the Role of the AHR in Blood Cell Specifications 5R01ES025409-04 4
2018 Mechanisms of cis-acting HbF regulation in sickle cell anemia 5R01HL133350-02 11
2018 Defining the Role of the AHR in Blood Cell Specifications 5R01ES025409-03 4
2017 Mechanisms of cis-acting HbF regulation in sickle cell anemia 1R01HL133350-01A1 11
Showing 10 of 24 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Heinze D, Park S, McCracken A, Haratianfar M, Lindstrom J, Villacorta-Martin C, Mithal A, Wang F, Yang MW, Murphy G, Mostoslavsky G. Notch activation during early mesoderm induction modulates emergence of the T/NK cell lineage from human iPSCs. Stem Cell Reports. 2022 Dec 13; 17(12):2610-2628. PMID: 36332629; PMCID: PMC9768581; DOI: 10.1016/j.stemcr.2022.10.007;
     
  2. Sae-Lee W, McCafferty CL, Verbeke EJ, Havugimana PC, Papoulas O, McWhite CD, Houser JR, Vanuytsel K, Murphy GJ, Drew K, Emili A, Taylor DW, Marcotte EM. The protein organization of a red blood cell. Cell Rep. 2022 Jul 19; 40(3):111103.View Related Profiles. PMID: 35858567
     
  3. Teo WW, Cao X, Wu CS, Tan HK, Zhou Q, Gao C, Vanuytsel K, Kumar SS, Murphy GJ, Yang H, Chai L, Tenen DG. Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation. Commun Biol. 2022 Apr 11; 5(1):343.View Related Profiles. PMID: 35411071; PMCID: PMC9001699; DOI: 10.1038/s42003-022-03250-x;
     
  4. Vanuytsel K, Yeung AK, Dowrey TW, Murphy GJ, Belkina AC. CPHEN-013: Comprehensive phenotyping of hematopoietic stem and progenitor cells in the human fetal liver. Cytometry A. 2022 Nov; 101(11):903-908.View Related Profiles. PMID: 35253987
     
  5. Vanuytsel K, Villacorta-Martin C, Lindstrom-Vautrin J, Wang Z, Garcia-Beltran WF, Vrbanac V, Parsons D, Lam EC, Matte TM, Dowrey TW, Kumar SS, Li M, Wang F, Yeung AK, Mostoslavsky G, Dries R, Campbell JD, Belkina AC, Balazs AB, Murphy GJ. Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment. Nat Commun. 2022 03 01; 13(1):1103.View Related Profiles. PMID: 35232959; PMCID: PMC8888592; DOI: 10.1038/s41467-022-28616-x;
     
  6. Sun Y, Habara A, Le CQ, Nguyen N, Chen R, Murphy GJ, Chui DHK, Steinberg MH, Cui S. Pharmacologic induction of PGC-1a stimulates fetal haemoglobin gene expression. Br J Haematol. 2022 Apr; 197(1):97-109.View Related Profiles. PMID: 35118652
     
  7. Giadone RM, Ghosh, S, Murphy GJ. Editor(s): Alexander Birbrair, in Advances in Stem Cell Biology, Novel Concepts in iPSC Disease Modeling. Patient-specific induced pluripotent stem cells for understanding and assessing novel therapeutics for multisystem transthyretin amyloid disease. Academic Press, Elsevier. London. 2022; 15:105-122. View Publication
  8. Blakemore D, Vilaplana-Lopera N, Almaghrabi R, Gonzalez E, Moya M, Ward C, Murphy G, Gambus A, Petermann E, Stewart GS, García P. MYBL2 and ATM suppress replication stress in pluripotent stem cells. EMBO Rep. 2021 05 05; 22(5):e51120. PMID: 33779025; PMCID: PMC8097389; DOI: 10.15252/embr.202051120;
     
  9. Yeung AK, Villacorta-Martin C, Hon S, Rock JR, Murphy GJ. Lung megakaryocytes display distinct transcriptional and phenotypic properties. Blood Adv. 2020 12 22; 4(24):6204-6217.View Related Profiles. PMID: 33351116; PMCID: PMC7757004; DOI: 10.1182/bloodadvances.2020002843;
     
  10. Giadone RM, Mithal A, Miller GJ, Matte TM, Yeung AK, Dowrey TW, Werder RB, Miller NS, Andry CD, Vanuytsel K, Murphy GJ. qRT-PCR Platforms for Diagnosing and Reporting SARS-CoV-2 Infection in Human Samples. STAR Protoc. 2020 Sep 18; 1(2):100102.View Related Profiles. PMID: 32954369; PMCID: PMC7490627; DOI: 10.1016/j.xpro.2020.100102;
     
Showing 10 of 50 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 50 publications over 19 distinct years, with a maximum of 7 publications in 2022

YearPublications
19992
20011
20031
20043
20061
20092
20102
20111
20121
20132
20142
20151
20165
20174
20185
20194
20205
20211
20227

2021 BUSM: National Academy of Medicine (NAM) Catalyst Award in Healthy Longevity
2020 BUSM: Massachusetts Pathogen Readiness (MassCPR) Award
2020 BUSM: Graduate Medical Sciences (GMS) Exceptional Mentoring Award
2013 BUSM: National Blood Foundation (NBF) Scholar Award
2012 BUSM: Amyloid Foundation Junior Investigator Award
2011 BUSM: American Society of Hematology (ASH) Scholar Award
2008 Harvard Medical School: NIH NRSA Individual Fellowship Award
2002 Oxford University: Graduate Scholar in Molecular Biology

My success as an independent investigator in an extraordinarily competitive branch of science is the direct result of the thoughtful and effective mentorship I have received throughout my career. As such, I understand the critical importance of mentorship, and it has been the foundation upon which I built my lab and surrounding Center, the emphasis point in my role as the Director of Research in my Division, and is central to my philosophy in training the next great generation of scientists and clinicians. Although I am a mid-career investigator, I have had extensive experience with scientific leadership. Along with my two colleagues Gustavo Mostoslavsky MD/PhD and Darrell Kotton MD, I founded and direct the Boston University and Boston Medical Center’s Center for Regenerative Medicine (CReM) (www.bumc.bu.edu/stemcells), where 50 scientists including 12 faculty members work together, synergistically in a multi-disciplinary approach to advancing stem cell biology and regenerative medicine. In founding the CReM, I constructed and implemented a strategic plan steeped in guiding principles such as scientific rigor, collegiality, and mentorship. Under my direction, the CReM has been highly successful and has become the number one Center on campus as judged by all metrics of productivity including funding, high impact publications, and the recruitment and placement of the highest quality trainees. These foundational keys are also directly imparted to my students and trainees. My previous students and fellows trained in these disciplines have been extremely successful (Sarah S. Rozelle: completed her PhD, became a postdoctoral fellow at Harvard Medical School, and is now an Assistant Professor at UMASS Lowell; Brenden W. Smith: completed his PhD in June 2016, became a staff scientist and presidential postdoctoral fellow at Novartis, and is now the lead scientist in drug delivery at Platelet Biogenesis; Elizabeth Zulick completed her postdoctoral fellowship, attained am Assistant Professorship at Northeastern University, and now directs the entire Biology and Biotechnology platforms at the University, Kim Vanuytsel was recently promoted to Research Assistant Professor in the Division of Hematology-Oncology in the Department of Medicine at BUSM after the completion of a highly successful postdoctoral fellowship within my group). All of the research technicians who have passed through my lab have gone onto PhD or MD programs, as again, one of the CReMs founding principles is that of quality mentorship at all levels. I am also a sought after dissertation advisor for PhD and MD/PhD students having mentored more than 15 students in this capacity including those at nearby institutions including Harvard.
I am the recent recipient of an award for exceptional mentorship by Graduate Medical Sciences and the PhD program here at the University. I have also been involved in the development of the integrated Program in Biomedical Sciences (PiBS) graduate program, having taught several courses including a Stem Cell and Regenerative Medicine module pioneered by myself and my colleagues in the CReM. I am also a member of the PiBS admissions committee where I have a dedicated interest in recruiting diverse applicants.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Education Mentor
  • Project Mentor
  • Research / Scholarly Mentor
  • Work / Life Integration Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

670 Albany St., Suite 208
Boston MA 02118
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