George J. Murphy, PhD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Hematology & Medical Oncology

PhD, University of Oxford



I have developed an approach to science that utilizes multiple stem cell-based platforms to answer basic biological questions and combat human disease. My current research portfolio is a direct reflection of my evolution as a scientist in which my early studies of hematopoietic development led to the generation of useful tools and reagents as well as methodologies and insights that synergized into a potent platform in the emerging and rapidly expanding field of pluripotent stem cell biology. My group is composed of dynamic and passionate young researchers and together we have impacted the following areas of investigation:

1.) Developmental hematopoiesis
2.) The generation, culture, and directed differentiation of pluripotent stem cells
3.) Pluripotent stem cell-based modeling of hematopoiesis: a Platform for Production of Transfusable Human Blood Cells
4.) Pluripotent Stem Cell Modeling of Human Disease: The ‘Clinical Trial in a Test Tube’: Sickle Cell Anemia; Amyloidosis

Boston Medical Center



2013 BUSM: National Blood Foundation (NBF) Scholar Award
2012 BUSM: Amyloid Foundation Junior Investigator Award
2011 BUSM: American Society of Hematology (ASH) Scholar Award
2008 Harvard Medical School: NIH NRSA Individual Fellowship Award
2002 Oxford University: Graduate Scholar in Molecular Biology


DEFINING THE ROLE OF THE AHR IN BLOOD CELL SPECIFICATION
01/01/2016 - 11/30/2020 (Co-PI)
PI: David H. Sherr, PhD
NIH/National Institute of Environmental Health Sciences
5R01ES025409-03

GLOBIN GENE EXPRESSION IN SICKLE CELL GENOTYPE-SPECIFIC IPS CELLS
07/05/2011 - 06/30/2017 (Co-PI)
PI: Martin H. Steinberg, MD
NIH/National Heart, Lung, and Blood Institute
5U01HL107443-05

STRESS GRANULES AND THE BIOLOGY OF TDP-43
01/01/2016 - 12/31/2016 (Co-PI)
PI: Benjamin Wolozin, MD, PhD
NIH/National Institute of Environmental Health Sciences
4R01ES020395-05

GLOBIN GENE EXPRESSION IN SICKLE CELL GENOTYPE-SPECIFIC IPS CELLS
07/05/2011 - 06/30/2016 (Co-PI)
PI: Martin H. Steinberg, MD
NIH/National Heart, Lung, and Blood Institute
1U01HL107443-01

STRESS GRANULES AND THE BIOLOGY OF TDP-43
03/01/2012 - 12/31/2015 (Co-PI)
PI: Benjamin Wolozin, MD, PhD
NIH/National Institute of Environmental Health Sciences
5R01ES020395-04

BOSTON UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD (CTSA) PROGRAM UL1
05/01/2008 - 04/30/2013 (PI of Sub-Project / SP)
PI: David M. Center, MD
NIH/National Center for Health Research Resources
3UL1RR025771-04


Mechanisms of cis-acting HbF regulation in sickle cell anemia
04/01/2017 - 03/31/2021 (PI)
NIH-NHLBI
5R01HL133350-02

Defining the role of the AHR in Blood Cell Specification
01/01/2016 - 11/30/2020 (PI)
Trustees of Boston University NIH-NIEHS

Megakaryocyte Transcription Factor Activation to Enhance In Vitro Platelet Production from Humans IP
09/10/2015 - 05/31/2019 (PI)
Children's Hospital NIH-NHLBI
5R01HL130793-04

Targeting Endogenous Signaling Pathways to Amliorate Systemic Amyloidoses
09/08/2014 - 06/30/2018 (PI)
The Scripps Research Institute NIH-NIDDK

iPSC-based Modeling and Therapeutic Intervention in Sickle Cell Disease
12/15/2016 - 12/14/2017 (PI)
Incyte Corporation

Globin Gene Expression in Sickle Cell Genotype-Specific iPS Cells
07/05/2011 - 06/30/2017 (PI)
Trustees of Boston University NIH-NHLBI

Pluripotent stem cells in the modeling of blood disease and the production of transfusable human red
07/01/2013 - 06/30/2015 (PI)
National Blood Fdtn

Induced Pluripotent Stem Cell Modeling of Human Hereditary Amyloidosis
01/01/2012 - 12/31/2014 (PI)
Amyloidosis Foundation

iPS Cells: Novel Applications for Thrombocytopania
07/01/2011 - 06/30/2013 (PI)
American Society of Hematology

Characterization of human hematopoietic and endodermal progenitors derived from iPS cells free of re
09/30/2009 - 08/31/2011 (PI)
Trustees of Boston University NIH-NHLBI



Yr Title Project-Sub Proj Pubs
2018 Mechanisms of cis-acting HbF regulation in sickle cell anemia 5R01HL133350-02
2018 Defining the Role of the AHR in Blood Cell Specifications 5R01ES025409-03 1
2017 Mechanisms of cis-acting HbF regulation in sickle cell anemia 1R01HL133350-01A1
2017 Defining the Role of the AHR in Blood Cell Specifications 5R01ES025409-02 1
2017 TARGETING ENDOGENOUS SIGNALING PATHWAYS TO AMELIORATE SYSTEMIC AMYLOIDOSES 5R01DK102635-04 5
2016 Defining the Role of the AHR in Blood Cell Specifications 1R01ES025409-01A1 1
2016 TARGETING ENDOGENOUS SIGNALING PATHWAYS TO AMELIORATE SYSTEMIC AMYLOIDOSES 5R01DK102635-03 5
2014 TARGETING ENDOGENOUS SIGNALING PATHWAYS TO AMELIORATE SYSTEMIC AMYLOIDOSES 1R01DK102635-01 5
2014 Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells 5U01HL107443-04 6
2013 Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells 5U01HL107443-03 6
Showing 10 of 15 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Seo H, Chen SJ, Hashimoto K, Endo H, Nishi Y, Ohta A, Yamamoto T, Hotta A, Sawaguchi A, Hayashi H, Koseki N, Murphy GJ, Fukuda K, Sugimoto N, Eto K. A ß1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production. Blood Adv. 2018 Sep 11; 2(17):2262-2272. PMID: 30206099.
     
  2. Vanuytsel K, Matte T, Leung A, Naing ZH, Morrison T, Chui DHK, Steinberg MH, Murphy GJ. Induced pluripotent stem cell-based mapping of ß-globin expression throughout human erythropoietic development. Blood Adv. 2018 Aug 14; 2(15):1998-2011.View Related Profiles. PMID: 30108108.
     
  3. Giadone RM, Rosarda JD, Akepati PR, Thomas AC, Boldbaatar B, James MF, Wilson AA, Sanchorawala V, Connors LH, Berk JL, Wiseman RL, Murphy GJ. A library of ATTR amyloidosis patient-specific induced pluripotent stem cells for disease modelling and in vitro testing of novel therapeutics. Amyloid. 2018 Jul 21; 1-8.View Related Profiles. PMID: 30032658.
     
  4. Leung A, Zulick E, Skvir N, Vanuytsel K, Morrison TA, Naing ZH, Wang Z, Dai Y, Chui DHK, Steinberg MH, Sherr DH, Murphy GJ. Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells. Stem Cells. 2018 Jul; 36(7):1004-1019.View Related Profiles. PMID: 29569827.
     
  5. Morrison TA, Wilcox I, Luo HY, Farrell JJ, Kurita R, Nakamura Y, Murphy GJ, Cui S, Steinberg MH, Chui DHK. A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression. Blood Cells Mol Dis. 2018 Mar; 69:1-9.View Related Profiles. PMID: 29227829.
     
  6. Shaikho EM, Farrell JJ, Alsultan A, Qutub H, Al-Ali AK, Figueiredo MS, Chui DHK, Farrer LA, Murphy GJ, Mostoslavsky G, Sebastiani P, Steinberg MH. A phased SNP-based classification of sickle cell anemia HBB haplotypes. BMC Genomics. 2017 Aug 11; 18(1):608.View Related Profiles. PMID: 28800727.
     
  7. Ash PEA, Stanford EA, Al Abdulatif A, Ramirez-Cardenas A, Ballance HI, Boudeau S, Jeh A, Murithi JM, Tripodis Y, Murphy GJ, Sherr DH, Wolozin B. Dioxins and related environmental contaminants increase TDP-43 levels. Mol Neurodegener. 2017 05 05; 12(1):35.View Related Profiles. PMID: 28476168; DOI: 10.1186/s13024-017-0177-9;.
     
  8. Park S, Gianotti-Sommer A, Molina-Estevez FJ, Vanuytsel K, Skvir N, Leung A, Rozelle SS, Shaikho EM, Weir I, Jiang Z, Luo HY, Chui DHK, Figueiredo MS, Alsultan A, Al-Ali A, Sebastiani P, Steinberg MH, Mostoslavsky G, Murphy GJ. A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 Apr 11; 8(4):1076-1085.View Related Profiles. PMID: 28111279; DOI: 10.1016/j.stemcr.2016.12.017;.
     
  9. Vathipadiekal V, Farrell JJ, Wang S, Edward HL, Shappell H, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Alsuliman A, Qutub HO, Simkin I, Farrer LA, Jiang Z, Luo HY, Huang S, Mostoslavsky G, Murphy GJ, Patra PK, Chui DH, Alsultan A, Al-Ali AK, Sebastiani P, Steinberg MH. A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia. Am J Hematol. 2016 Nov; 91(11):1118-1122.View Related Profiles. PMID: 27501013; DOI: 10.1002/ajh.24527;.
     
  10. Smith BW, Stanford EA, Sherr DH, Murphy GJ. Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development. Stem Cells Int. 2016; 2016:2574152.View Related Profiles. PMID: 27148368; DOI: 10.1155/2016/2574152;.
     
Showing 10 of 32 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 32 publications over 15 distinct years, with a maximum of 5 publications in 2016

YearPublications
19992
20011
20031
20043
20061
20092
20102
20111
20121
20132
20142
20151
20165
20174
20184
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Amyloidosis
Embryonic Stem Cells
gene therapy
gene transfer
Hematopoiesis
induced Pluripotent Stem Cells
molecular biology
retorviruses
Sickle Cell Anemia
stem cell biology

I have the training, diverse background, and the expertise necessary to mentor students in the fields of stem cell biology and regenerative medicine. My previous pre-doctoral students trained in these disciplines have been extremely successful (Sarah S. Rozelle: completed PhD and currently a postdoctoral fellow at Harvard Medical School; Shirley N. Nah: completed MS and currently a medical student at the University of Texas; Brenden W. Smith: completed PhD June 2016 and currently a staff scientist and presidential postdoctoral fellow at Novartis). Additionally, I have trained individuals from diverse ethnic and cultural backgrounds including a former technician from a nomadic family in Kenya (who is now an accomplished graduate student at Columbia University) and my current technician who is an immigrant from Burma (who has just gained entrance into medical school).

Available to Mentor as: (Review Mentor Role Definitions):
  • Career Mentor
  • Project Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

Research Overview
Brewing Blood: Transfusable Stem Cell-Derived Blood Products
Lab TV: Dr. Murphy
CBS News Boston: Brewing Blood

Promotions to Associate Professor Go to 16 on Medical Campus

BU Today 7/6/2018

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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617.638.7520
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