George J. Murphy, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Hematology & Medical Oncology

PhD, University of Oxford
BS, Trinity College

I have developed an approach to science that utilizes multiple stem cell-based platforms to answer basic biological questions and combat human disease. My current research portfolio is a direct reflection of my evolution as a scientist in which my early studies of hematopoietic development led to the generation of useful tools and reagents as well as methodologies and insights that synergized into a potent platform in the emerging and rapidly expanding field of pluripotent stem cell biology. My group is composed of dynamic and passionate young researchers and together we have impacted the following areas of investigation:

1.) Developmental hematopoiesis
2.) The generation, culture, and directed differentiation of pluripotent stem cells
3.) Pluripotent stem cell-based modeling of hematopoiesis: a Platform for Production of Transfusable Human Blood Cells
4.) Pluripotent Stem Cell Modeling of Human Disease: The ‘Clinical Trial in a Test Tube’: Sickle Cell Anemia; Amyloidosis
5.) Understanding the molecular and functional basis of exceptional longevity: Dissecting resistance to aging-related disease

Diversity, Equity, Inclusion and Accessibility

As a first generation student, the product of a broken home in a low resource setting, and someone fortunate enough to have overcome many barriers on the path to a career in academia, I am deeply committed to diversity, equity and inclusion efforts to broaden the spectrum of those able to access a career in science and medicine.

Mentorship As a Driver of DEI:
My success as an independent investigator in an extraordinarily competitive branch of science is the direct result of the thoughtful and effective mentorship I have received throughout my career. As such, I understand the critical importance of mentorship, and it has been the foundation upon which I built my lab and surrounding Center for Regenerative Medicine (CReM), the emphasis point in my role as the Director of Research in my Division, and is central to my philosophy in training the next great diverse generation of scientists and clinicians. In accordance with my belief that diverse teams are more impactful and productive, my past trainees have included an individual from a nomadic family in Africa who had been greatly impacted by the HIV epidemic, a refugee from Myanmar (Burma), as well as many first generation students from modest backgrounds…all who have gone on to achieve tremendous success and become exceptional mentors themselves.

A Focus on Diseases That Directly Impact our Surrounding, Underserved Community:
At the CReM, we focus on diseases that directly impact our surrounding underserved community, as one of our main charges is to bring cutting edge, transformative research to the masses. In essence, we like to think that we perform ‘research with reach’ that we hope has the ability to one day transform the lives of all patients here at Boston Medical Center (BMC) and the world, regardless of race, gender, sexual orientation or socio-economic status. One of our goals is to revolutionize the care of patients living with Sickle Cell Disease (SCD), and to one day completely cure the disorder. But there are tremendous health disparities surrounding SCD—although it’s the most common genetic disease worldwide, research has been chronically underfunded, in part due to systemic racism. As a countermeasure, BMC has pulled together a group of world experts in the field, and we all share the vision of better patient care and eventually, a world without sickle cell disease. That mission – that mindset – is unique and gets right to the heart of health equity; Our goal is to remove healthcare obstacles and to give every person the chance to live their healthiest, fullest life. Lastly, although there are very exciting, emerging therapies that may make this possible, a personal charge for myself is also to ensure that these emerging, potentially transformative therapies will be accessible to all:

Equity and Inclusion Efforts During the COVID-19 Pandemic:
At the height of the pandemic, when rates of infection were skyrocketing, when everything was shut down including most academic centers, when it was virtually impossible to get a COVID test in an appreciable time frame in order to make critical care decisions and isolate those that were infected, I led a Team that mobilized and repurposed ourselves and our center, to build our own FDA approved COVID test, from easily sourced materials that could be found in any lab, in 7 days with a testing turn around time of less than 24 hours. And in true BMC fashion, as soon as we accomplished this, we immediately began to share this information, this ‘blueprint’ for how to run the test, throughout Boston and around the World. As a safety net hospital, our underserved patient population often goes without access to state-of-the-art clinical trials and in this case, rapid COVID testing. This initiative was one of the first of its kind in the country and allowed all of our patients, regardless of socio-economic status, to access rapidly emerging technology leading to more effective care for COVID's most vulnerable victims:
Vanuytsel K, Mithal A, Giadone RM, Yeung AK, Matte TM, Dowrey TW, Werder RB, Miller GJ, Miller NS, Andry CD, Murphy GJ. (2020) Rapid implementation of a SARS-CoV-2 diagnostic quantitative real-time PCR test with emergency use authorization at a large academic safety net hospital. Med Cell Press.

Other Efforts:
Anti-Racism Committee, Center for Regenerative Medicine (CReM), BUSM
Anti-Racism Steering Committee, Division of Hematology-Oncology, BUSM

Boston University
Pulmonary Center

Boston University
Center for Regenerative Medicine

Boston University
Center of Excellence in Sickle Cell Disease

Boston University
Evans Center for Interdisciplinary Biomedical Research

Boston Medical Center

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Boston University
Genome Science Institute

Understanding the Symbiosis Between Megakaryocytes and the Lung Microenvironment
09/01/2020 - 08/31/2024 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute

Understanding the impact of group 2 innate lymphoid cells on airway epithelial regeneration and repair
04/01/2022 - 03/31/2024 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute

2021 ASH Hematology Opportunities for the Next-Generation of Research Scientists (HONORS) Award
07/01/2021 - 06/30/2022 (Key Person / Mentor)
American Society of Hematology

Defining the role of the AHR in Blood Cell Specification
01/01/2016 - 11/30/2021 (Multi-PI)
PI: George J. Murphy, PhD
NIH/National Institute of Environmental Health Sciences

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2017 (Multi-PI)
PI: George J. Murphy, PhD
NIH/National Heart, Lung, and Blood Institute

Stress Granules and the Biology of TDP-43
01/01/2016 - 12/31/2016 (Multi-PI)
PI: George J. Murphy, PhD
NIH/National Institute of Environmental Health Sciences

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2016 (Co-Investigator)
PI: Martin H. Steinberg, MD
NIH/National Heart, Lung, and Blood Institute

Stress Granules and the Biology of TDP-43
03/01/2012 - 12/31/2015 (Co-Investigator)
PI: Benjamin Wolozin, MD, PhD
NIH/National Institute of Environmental Health Sciences

Boston University Clinical and Translational Science Award (CTSA) Program UL1
05/01/2008 - 04/30/2013 (PI of Sub-Project / SP)
PI: David M. Center, MD
NIH/National Center for Health Research Resources

Resilience/Resistance to Alzheimer's Disease in Centenarians and Offspring (RADCO)
09/30/2021 - 08/31/2024 (PI)
Trustees of Boston University, BUMC National Institute o

Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategies
09/15/2019 - 06/30/2024 (Multi-PI)
PI: George J. Murphy, PhD
Trustees of Boston University,CRC National Institute o

Understanding Hepatic Proteostasis in Systemic Amyloid Diseases
07/14/2020 - 03/31/2024 (PI)
Scripps Research Institute National Institutes

Mechanisms of cis-acting HbF regulation in sickle cell anemia
04/01/2019 - 03/31/2023 (PI)
National Institutes of Health/DHHS/NIH

Large scale, cost-efficient screening and detection of SARS-CoV-2 (COVID-19) in the underserved population
05/01/2020 - 12/31/2021 (PI)
Harvard Medical School MLSC

Defining the role of the AHR in Blood Cell Specification
01/01/2016 - 11/30/2020 (PI)
Trustees of Boston University, BUMC National Institute o

iPSC-based Modeling and Therapeutic Intervention In Sickle Cell Disease
09/23/2019 - 09/22/2020 (PI)
Beam Therapeutics

Activation of Megakaryocyte Transcription Factors to Enhance In Vitro Platelet Production
09/10/2015 - 05/31/2019 (PI)
Boston Children's Hospital National Heart, Lung

Targeting Endogenous Signaling Pathways to Amliorate Systemic Amyloidoses
09/08/2014 - 06/30/2018 (PI)
The Scripps Research Institute NIH-NIDDK

iPSC-based Modeling and Therapeutic Intervention in Sickle Cell Disease
12/15/2016 - 12/14/2017 (PI)
Incyte Corporation

Showing 10 of 15 results. Show All Results


Yr Title Project-Sub Proj Pubs
2020 Mechanisms of cis-acting HbF regulation in sickle cell anemia 5R01HL133350-04 11
2020 Defining the Role of the AHR in Blood Cell Specifications 5R01ES025409-05 4
2019 Mechanisms of cis-acting HbF regulation in sickle cell anemia 5R01HL133350-03 11
2019 Defining the Role of the AHR in Blood Cell Specifications 5R01ES025409-04 4
2018 Mechanisms of cis-acting HbF regulation in sickle cell anemia 5R01HL133350-02 11
2018 Defining the Role of the AHR in Blood Cell Specifications 5R01ES025409-03 4
Showing 10 of 25 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Edwards CV, Ferri GM, Villegas-Galaviz J, Ghosh S, Bawa PS, Wang F, Klimtchuk E, Ajayi TB, Morgan GJ, Prokaeva T, Staron A, Ruberg FL, Sanchorawala V, Giadone RM, Murphy GJ. Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition. bioRxiv. 2024 Mar 16.View Related Profiles. PMID: 38558967; PMCID: PMC10980073; DOI: 10.1101/2024.03.14.584987;
  2. Dowrey TW, Cranston SF, Skvir N, Lok Y, Gould B, Petrowitz B, Villar D, Shan J, James M, Dodge M, Belkina AC, Giadone RM, Sebastiani P, Perls TT, Andersen SL, Murphy GJ. A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring. bioRxiv. 2024 Mar 14.View Related Profiles. PMID: 38559230; PMCID: PMC10979955; DOI: 10.1101/2024.03.12.584663;
  3. Yeung AK, Villacorta-Martin C, Lindstrom-Vautrin J, Belkina AC, Vanuytsel K, Dowrey TW, Ysasi AB, Bawa P, Wang F, Vrbanac V, Mostoslavsky G, Balazs AB, Murphy GJ. De novo hematopoiesis from the fetal lung. Blood Adv. 2023 Nov 28; 7(22):6898-6912.View Related Profiles. PMID: 37729429; PMCID: PMC10685174; DOI: 10.1182/bloodadvances.2022008347;
  4. Hoffman SE, Dowrey TW, Villacorta Martin C, Bi K, Titchen B, Johri S, DelloStritto L, Patel M, Mackichan C, Inga S, Chen J, Grimaldi G, Napolitano S, Wakiro I, Wu J, Yeung J, Rotem A, Sicinska E, Shannon E, Clancy T, Wang J, Denning S, Brais L, Besson NR, Pfaff KL, Huang Y, Kao KZ, Rodig S, Hornick JL, Vigneau S, Park J, Kulke MH, Chan J, Van Allen EM, Murphy GJ. Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors. Sci Adv. 2023 Sep 29; 9(39):eadd9668.View Related Profiles. PMID: 37756410; PMCID: PMC10530100; DOI: 10.1126/sciadv.add9668;
  5. Kretov DA, Folkes L, Mora-Martin A, Syedah N, Walawalkar IA, Vanyustel K, Moxon S, Murphy GJ, Cifuentes D. The miR-144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis. bioRxiv. 2023 Jul 19.View Related Profiles. PMID: 37503141; PMCID: PMC10370056; DOI: 10.1101/2023.07.18.549576;
  6. Ghosh S, Villacorta-Martin C, Lindstrom-Vautrin J, Kenney D, Golden CS, Edwards CV, Sanchorawala V, Connors LH, Giadone RM, Murphy GJ. Mapping cellular response to destabilized transthyretin reveals cell- and amyloidogenic protein-specific signatures. Amyloid. 2023 Dec; 30(4):379-393.View Related Profiles. PMID: 37439769; DOI: 10.1080/13506129.2023.2224494;
  7. Karagiannis TT, Dowrey TW, Villacorta-Martin C, Montano M, Reed E, Belkina AC, Andersen SL, Perls TT, Monti S, Murphy GJ, Sebastiani P. Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity. EBioMedicine. 2023 Apr; 90:104514.View Related Profiles. PMID: 37005201; PMCID: PMC10114155; DOI: 10.1016/j.ebiom.2023.104514;
  8. Heinze D, Park S, McCracken A, Haratianfar M, Lindstrom J, Villacorta-Martin C, Mithal A, Wang F, Yang MW, Murphy G, Mostoslavsky G. Notch activation during early mesoderm induction modulates emergence of the T/NK cell lineage from human iPSCs. Stem Cell Reports. 2022 Dec 13; 17(12):2610-2628.View Related Profiles. PMID: 36332629; PMCID: PMC9768581; DOI: 10.1016/j.stemcr.2022.10.007;
  9. Sae-Lee W, McCafferty CL, Verbeke EJ, Havugimana PC, Papoulas O, McWhite CD, Houser JR, Vanuytsel K, Murphy GJ, Drew K, Emili A, Taylor DW, Marcotte EM. The protein organization of a red blood cell. Cell Rep. 2022 Jul 19; 40(3):111103.View Related Profiles. PMID: 35858567; PMCID: PMC9764456; DOI: 10.1016/j.celrep.2022.111103;
  10. Teo WW, Cao X, Wu CS, Tan HK, Zhou Q, Gao C, Vanuytsel K, Kumar SS, Murphy GJ, Yang H, Chai L, Tenen DG. Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation. Commun Biol. 2022 Apr 11; 5(1):343.View Related Profiles. PMID: 35411071; PMCID: PMC9001699; DOI: 10.1038/s42003-022-03250-x;
Showing 10 of 57 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 57 publications over 21 distinct years, with a maximum of 7 publications in 2022


Recent (within 3 months)

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The Brink 2/21/2024


‘It’s just amazing to me that I’m still here’: Great-great-grandma, 105, reveals secret to long life

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104-year-old New Yorker reveals secret to long life: ‘I love my beer’

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Study: Strong immune cells may be the key to living to 100

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DNA study reveals one key factor that helps some people live beyond 100

Yahoo News 4/4/2023

Election 2020: A Day of Nervousness Turns to a Night of Uncertainty

BU Today 11/3/2020

CityLine: Sunday, Oct. 11, 2020: BMC Doctors and Sickle Cell

WCVB 10/11/2020

Why Are Therapeutics Still Lagging for Sickle Cell Disease? In Short, Systemic Racism

HealthCity 9/28/2020

In Sweats or Suits, Graduate Students Embrace the Remote PhD Dissertation Defense

BU Today 8/10/2020

Academic Lab Quickly Converts to Perform SARS-CoV-2 Testing

Lab Pulse 5/19/2020

Blueprint For Adapting US Labs for COVID-19 Diagnostic Testing

Drug Target Review 5/13/2020

Academic Labs Pivot To Fill Coronavirus Testing Gap

WBUR 4/20/2020

Untapped potential: More US labs could be providing tests for coronavirus

Nature 4/20/2020

Logistical Hurdles Leave COVID-19 Test Kits Unused

The Scientist 4/10/2020

Thousands of coronavirus tests are going unused in US labs

Nature 4/9/2020

At This Research Center, Art’s Part Of The Equation

The Boston Globe 4/29/2019

Promotions to Associate Professor Go to 16 on Medical Campus

BU Today 7/6/2018

2021 BUSM: National Academy of Medicine (NAM) Catalyst Award in Healthy Longevity
2020 BUSM: Massachusetts Pathogen Readiness (MassCPR) Award
2020 BUSM: Graduate Medical Sciences (GMS) Exceptional Mentoring Award
2013 BUSM: National Blood Foundation (NBF) Scholar Award
2012 BUSM: Amyloid Foundation Junior Investigator Award
2011 BUSM: American Society of Hematology (ASH) Scholar Award
2008 Harvard Medical School: NIH NRSA Individual Fellowship Award
2002 Oxford University: Graduate Scholar in Molecular Biology

My success as an independent investigator in an extraordinarily competitive branch of science is the direct result of the thoughtful and effective mentorship I have received throughout my career. As such, I understand the critical importance of mentorship, and it has been the foundation upon which I built my lab and surrounding Center, the emphasis point in my role as the Director of Research in my Division, and is central to my philosophy in training the next great generation of scientists and clinicians. Although I am a mid-career investigator, I have had extensive experience with scientific leadership. Along with my two colleagues Gustavo Mostoslavsky MD/PhD and Darrell Kotton MD, I founded and direct the Boston University and Boston Medical Center’s Center for Regenerative Medicine (CReM) (, where 50 scientists including 12 faculty members work together, synergistically in a multi-disciplinary approach to advancing stem cell biology and regenerative medicine. In founding the CReM, I constructed and implemented a strategic plan steeped in guiding principles such as scientific rigor, collegiality, and mentorship. Under my direction, the CReM has been highly successful and has become the number one Center on campus as judged by all metrics of productivity including funding, high impact publications, and the recruitment and placement of the highest quality trainees. These foundational keys are also directly imparted to my students and trainees. My previous students and fellows trained in these disciplines have been extremely successful (Sarah S. Rozelle: completed her PhD, became a postdoctoral fellow at Harvard Medical School, and is now an Assistant Professor at UMASS Lowell; Brenden W. Smith: completed his PhD in June 2016, became a staff scientist and presidential postdoctoral fellow at Novartis, and is now the lead scientist in drug delivery at Platelet Biogenesis; Elizabeth Zulick completed her postdoctoral fellowship, attained am Assistant Professorship at Northeastern University, and now directs the entire Biology and Biotechnology platforms at the University, Kim Vanuytsel was recently promoted to Research Assistant Professor in the Division of Hematology-Oncology in the Department of Medicine at BUSM after the completion of a highly successful postdoctoral fellowship within my group). All of the research technicians who have passed through my lab have gone onto PhD or MD programs, as again, one of the CReMs founding principles is that of quality mentorship at all levels. I am also a sought after dissertation advisor for PhD and MD/PhD students having mentored more than 15 students in this capacity including those at nearby institutions including Harvard.
I am the recent recipient of an award for exceptional mentorship by Graduate Medical Sciences and the PhD program here at the University. I have also been involved in the development of the integrated Program in Biomedical Sciences (PiBS) graduate program, having taught several courses including a Stem Cell and Regenerative Medicine module pioneered by myself and my colleagues in the CReM. I am also a member of the PiBS admissions committee where I have a dedicated interest in recruiting diverse applicants.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Education Mentor
  • Project Mentor
  • Research / Scholarly Mentor
  • Work / Life Integration Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

670 Albany St., Suite 208
Boston MA 02118
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