George J. Murphy, PhD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Hematology & Medical Oncology

PhD, University of Oxford

I have developed an approach to science that utilizes multiple stem cell-based platforms to answer basic biological questions and combat human disease. My current research portfolio is a direct reflection of my evolution as a scientist in which my early studies of hematopoietic development led to the generation of useful tools and reagents as well as methodologies and insights that synergized into a potent platform in the emerging and rapidly expanding field of pluripotent stem cell biology. My group is composed of dynamic and passionate young researchers and together we have impacted the following areas of investigation:

1.) Developmental hematopoiesis
2.) The generation, culture, and directed differentiation of pluripotent stem cells
3.) Pluripotent stem cell-based modeling of hematopoiesis: a Platform for Production of Transfusable Human Blood Cells
4.) Pluripotent Stem Cell Modeling of Human Disease: The ‘Clinical Trial in a Test Tube’: Sickle Cell Anemia; Amyloidosis

Boston University
Pulmonary Center

Boston University
Center for Regenerative Medicine

Boston University
Center of Excellence in Sickle Cell Disease

Boston University
Evans Center for Interdisciplinary Biomedical Research

Boston Medical Center

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

Boston University
Genome Science Institute

Understanding the impact of group 2 innate lymphoid cells on airway epithelial regeneration and repair
04/01/2022 - 03/31/2024 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute

Understanding the Symbiosis Between Megakaryocytes and the Lung Microenvironment
09/01/2020 - 08/31/2022 (Key Person / Mentor)
NIH/National Heart, Lung, and Blood Institute

2021 ASH Hematology Opportunities for the Next-Generation of Research Scientists (HONORS) Award
07/01/2021 - 06/30/2022 (Key Person / Mentor)
American Society of Hematology

Defining the role of the AHR in Blood Cell Specification
01/01/2016 - 11/30/2021 (Multi-PI)
PI: George J. Murphy, PhD
NIH/National Institute of Environmental Health Sciences

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2017 (Multi-PI)
PI: George J. Murphy, PhD
NIH/National Heart, Lung, and Blood Institute

Stress Granules and the Biology of TDP-43
01/01/2016 - 12/31/2016 (Multi-PI)
PI: George J. Murphy, PhD
NIH/National Institute of Environmental Health Sciences

Globin Gene Expression in Sickle Cell Genotype-Specific iPS cells
07/05/2011 - 06/30/2016 (Co-Investigator)
PI: Martin H. Steinberg, MD
NIH/National Heart, Lung, and Blood Institute

Stress Granules and the Biology of TDP-43
03/01/2012 - 12/31/2015 (Co-Investigator)
PI: Benjamin Wolozin, MD, PhD
NIH/National Institute of Environmental Health Sciences

Boston University Clinical and Translational Science Award (CTSA) Program UL1
05/01/2008 - 04/30/2013 (PI of Sub-Project / SP)
PI: David M. Center, MD
NIH/National Center for Health Research Resources

Understanding Hepatic Proteostasis in Systemic Amyloid Diseases
07/14/2020 - 03/31/2023 (PI)
Scripps Research Institute National Institutes

Identifying protective omics profiles in centenarians and translating these int…
09/15/2019 - 04/30/2022 (PI)
Trustees of Boston University NIH-NIA

Mechanisms of cis-acting HbF regulation in sickle cell anemia
04/01/2017 - 03/31/2022 (PI)

Large scale, cost-efficient screening and detection of SARS-
05/01/2020 - 12/31/2021 (PI)
Harvard Medical School MLSC

Defining the role of the AHR in Blood Cell Specification
01/01/2016 - 11/30/2021 (PI)
Trustees of Boston University NIH-NIEHS

iPSC-based Modeling and Therapeutic Intervention In Sickle Cell Disease
09/23/2019 - 09/22/2020 (PI)
Beam Therapeutics

Megakaryocyte Transcription Factor Activation to Enhance In Vitro Platelet Production from Humans IP
09/10/2015 - 05/31/2019 (PI)
Children's Hospital NIH-NHLBI

Targeting Endogenous Signaling Pathways to Amliorate Systemic Amyloidoses
09/08/2014 - 06/30/2018 (PI)
The Scripps Research Institute NIH-NIDDK

iPSC-based Modeling and Therapeutic Intervention in Sickle Cell Disease
12/15/2016 - 12/14/2017 (PI)
Incyte Corporation

Globin Gene Expression in Sickle Cell Genotype-Specific iPS Cells
07/05/2011 - 06/30/2017 (PI)
Trustees of Boston University NIH-NHLBI

Showing 10 of 14 results. Show All Results


Yr Title Project-Sub Proj Pubs
2020 Mechanisms of cis-acting HbF regulation in sickle cell anemia 5R01HL133350-04 11
2020 Defining the Role of the AHR in Blood Cell Specifications 5R01ES025409-05 4
2019 Mechanisms of cis-acting HbF regulation in sickle cell anemia 5R01HL133350-03 11
2019 Defining the Role of the AHR in Blood Cell Specifications 5R01ES025409-04 4
2018 Mechanisms of cis-acting HbF regulation in sickle cell anemia 5R01HL133350-02 11
2018 Defining the Role of the AHR in Blood Cell Specifications 5R01ES025409-03 4
2017 Mechanisms of cis-acting HbF regulation in sickle cell anemia 1R01HL133350-01A1 11
Showing 10 of 24 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Sae-Lee W, McCafferty CL, Verbeke EJ, Havugimana PC, Papoulas O, McWhite CD, Houser JR, Vanuytsel K, Murphy GJ, Drew K, Emili A, Taylor DW, Marcotte EM. The protein organization of a red blood cell. Cell Rep. 2022 Jul 19; 40(3):111103.View Related Profiles. PMID: 35858567
  2. Teo WW, Cao X, Wu CS, Tan HK, Zhou Q, Gao C, Vanuytsel K, Kumar SS, Murphy GJ, Yang H, Chai L, Tenen DG. Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation. Commun Biol. 2022 Apr 11; 5(1):343.View Related Profiles. PMID: 35411071; PMCID: PMC9001699; DOI: 10.1038/s42003-022-03250-x;
  3. Vanuytsel K, Yeung AK, Dowrey TW, Murphy GJ, Belkina AC. Comprehensive phenotyping of hematopoietic stem and progenitor cells in the human fetal liver. Cytometry A. 2022 Mar 07.View Related Profiles. PMID: 35253987
  4. Vanuytsel K, Villacorta-Martin C, Lindstrom-Vautrin J, Wang Z, Garcia-Beltran WF, Vrbanac V, Parsons D, Lam EC, Matte TM, Dowrey TW, Kumar SS, Li M, Wang F, Yeung AK, Mostoslavsky G, Dries R, Campbell JD, Belkina AC, Balazs AB, Murphy GJ. Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment. Nat Commun. 2022 03 01; 13(1):1103.View Related Profiles. PMID: 35232959; PMCID: PMC8888592; DOI: 10.1038/s41467-022-28616-x;
  5. Sun Y, Habara A, Le CQ, Nguyen N, Chen R, Murphy GJ, Chui DHK, Steinberg MH, Cui S. Pharmacologic induction of PGC-1a stimulates fetal haemoglobin gene expression. Br J Haematol. 2022 Apr; 197(1):97-109.View Related Profiles. PMID: 35118652
  6. Giadone RM, Ghosh, S, Murphy GJ. Editor(s): Alexander Birbrair, in Advances in Stem Cell Biology, Novel Concepts in iPSC Disease Modeling. Patient-specific induced pluripotent stem cells for understanding and assessing novel therapeutics for multisystem transthyretin amyloid disease. Academic Press, Elsevier. London. 2022; 15:105-122. View Publication
  7. Blakemore D, Vilaplana-Lopera N, Almaghrabi R, Gonzalez E, Moya M, Ward C, Murphy G, Gambus A, Petermann E, Stewart GS, García P. MYBL2 and ATM suppress replication stress in pluripotent stem cells. EMBO Rep. 2021 05 05; 22(5):e51120. PMID: 33779025; PMCID: PMC8097389; DOI: 10.15252/embr.202051120;
  8. Yeung AK, Villacorta-Martin C, Hon S, Rock JR, Murphy GJ. Lung megakaryocytes display distinct transcriptional and phenotypic properties. Blood Adv. 2020 12 22; 4(24):6204-6217.View Related Profiles. PMID: 33351116; PMCID: PMC7757004; DOI: 10.1182/bloodadvances.2020002843;
  9. Giadone RM, Mithal A, Miller GJ, Matte TM, Yeung AK, Dowrey TW, Werder RB, Miller NS, Andry CD, Vanuytsel K, Murphy GJ. qRT-PCR Platforms for Diagnosing and Reporting SARS-CoV-2 Infection in Human Samples. STAR Protoc. 2020 Sep 18; 1(2):100102.View Related Profiles. PMID: 32954369; PMCID: PMC7490627; DOI: 10.1016/j.xpro.2020.100102;
  10. Giadone RM, Liberti DC, Matte TM, Rosarda JD, Torres-Arancivia C, Ghosh S, Diedrich JK, Pankow S, Skvir N, Jean JC, Yates JR, Wilson AA, Connors LH, Kotton DN, Wiseman RL, Murphy GJ. Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease. Stem Cell Reports. 2020 08 11; 15(2):515-528.View Related Profiles. PMID: 32735824; PMCID: PMC7419739; DOI: 10.1016/j.stemcr.2020.07.003;
Showing 10 of 49 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 49 publications over 19 distinct years, with a maximum of 6 publications in 2022


2021 BUSM: National Academy of Medicine (NAM) Catalyst Award in Healthy Longevity
2020 BUSM: Massachusetts Pathogen Readiness (MassCPR) Award
2020 BUSM: Graduate Medical Sciences (GMS) Exceptional Mentoring Award
2013 BUSM: National Blood Foundation (NBF) Scholar Award
2012 BUSM: Amyloid Foundation Junior Investigator Award
2011 BUSM: American Society of Hematology (ASH) Scholar Award
2008 Harvard Medical School: NIH NRSA Individual Fellowship Award
2002 Oxford University: Graduate Scholar in Molecular Biology

My success as an independent investigator in an extraordinarily competitive branch of science is the direct result of the thoughtful and effective mentorship I have received throughout my career. As such, I understand the critical importance of mentorship, and it has been the foundation upon which I built my lab and surrounding Center, the emphasis point in my role as the Director of Research in my Division, and is central to my philosophy in training the next great generation of scientists and clinicians. Although I am a mid-career investigator, I have had extensive experience with scientific leadership. Along with my two colleagues Gustavo Mostoslavsky MD/PhD and Darrell Kotton MD, I founded and direct the Boston University and Boston Medical Center’s Center for Regenerative Medicine (CReM) (, where 50 scientists including 12 faculty members work together, synergistically in a multi-disciplinary approach to advancing stem cell biology and regenerative medicine. In founding the CReM, I constructed and implemented a strategic plan steeped in guiding principles such as scientific rigor, collegiality, and mentorship. Under my direction, the CReM has been highly successful and has become the number one Center on campus as judged by all metrics of productivity including funding, high impact publications, and the recruitment and placement of the highest quality trainees. These foundational keys are also directly imparted to my students and trainees. My previous students and fellows trained in these disciplines have been extremely successful (Sarah S. Rozelle: completed her PhD, became a postdoctoral fellow at Harvard Medical School, and is now an Assistant Professor at UMASS Lowell; Brenden W. Smith: completed his PhD in June 2016, became a staff scientist and presidential postdoctoral fellow at Novartis, and is now the lead scientist in drug delivery at Platelet Biogenesis; Elizabeth Zulick completed her postdoctoral fellowship, attained am Assistant Professorship at Northeastern University, and now directs the entire Biology and Biotechnology platforms at the University, Kim Vanuytsel was recently promoted to Research Assistant Professor in the Division of Hematology-Oncology in the Department of Medicine at BUSM after the completion of a highly successful postdoctoral fellowship within my group). All of the research technicians who have passed through my lab have gone onto PhD or MD programs, as again, one of the CReMs founding principles is that of quality mentorship at all levels. I am also a sought after dissertation advisor for PhD and MD/PhD students having mentored more than 15 students in this capacity including those at nearby institutions including Harvard.
I am the recent recipient of an award for exceptional mentorship by Graduate Medical Sciences and the PhD program here at the University. I have also been involved in the development of the integrated Program in Biomedical Sciences (PiBS) graduate program, having taught several courses including a Stem Cell and Regenerative Medicine module pioneered by myself and my colleagues in the CReM. I am also a member of the PiBS admissions committee where I have a dedicated interest in recruiting diverse applicants.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Education Mentor
  • Project Mentor
  • Research / Scholarly Mentor
  • Work / Life Integration Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

670 Albany St., Suite 208
Boston MA 02118
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