Wilson S. Colucci, MD
Boston University Chobanian & Avedisian School of Medicine
Cardiovascular Medicine

MD, Boston University
BS, Union College

Research program studies the basic molecular and cellular mechanisms of myocardial remodeling, and the pathophysiology and treatment of heart failure.

Research Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

Boston University
Whitaker Cardiovascular Institute

Boston University
Evans Center for Interdisciplinary Biomedical Research

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Role of SERCA2 C674 oxidation in mediating apoptosis in cardiac myocytes
08/08/2018 - 08/20/2020 (Key Person / Mentor)
PI: Jena B. Goodman
NIH/National Heart, Lung, and Blood Institute

11/01/2008 - 10/31/2013 (PI)
Amgen, Inc.

12/15/2008 - 12/15/2011 (PI)
Pfizer, Inc.

01/21/2008 - 12/15/2011 (PI)
Scios Inc

The Balance Study:Treatment of Hyponatremia Based on Lixivaptan in Nyha Class III/IV Cardiac Patient Evaluation
06/01/2008 - 06/30/2010 (PI)
Cardiokine Biopharma

HMG CoA Reductase Inhibition and Inflammation, Oxidative Stress and Vascular Stiffness in Heart Failure
07/01/2005 - 06/30/2006 (Co-PI)
Heart Failure Society of America (HFSA)

Optimize HF Registry
05/01/2003 - 05/01/2005 (PI)
Outcome Sciences (GSK and Duke)

Clinical Evaluation of Acorn Cardiac Support Device Therapy in Patients with Dilated Cardiomyopathy - A Randomized Trial in the United States
02/01/2002 - 01/31/2005 (Co-PI)
Acorn Cardiovascular, Inc.

NO and O2 - In Post-Myocardial Infarction Remodeling and Failure
09/30/1998 - 08/31/2003 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL61639 05

Double-Blind, Randomized, Placebo-Controlled, Parallel Group Study Evaluating the Effects of Different Doses of LU135252 On Left Ventricle Dimensions, Function, and Left and Right Ventricle Mass, Neurohomone Levels, and Symptoms in Patients with Advanced
07/01/2000 - 06/30/2001 (PI)
Knoll Pharmaceutical Company

Showing 10 of 11 results. Show All Results

Effects of SGLT2 inhibition on cardiac mitochondrial function, energetics and remodeling in non-diabetic mice with heart failure with reduced ejection fraction
07/01/2020 - 06/30/2024 (PI)

Effects of cardiac SGLT inhibition on cardiac energetics and hemodynamic function in type II diabete
04/20/2018 - 04/19/2020 (PI)

Oxidative Stress in Myocardial Remodeling and Failure
04/01/2019 - 03/31/2020 (PI)
National Institutes of Health/DHHS/NIH

Effects of LCZ696 on Myocardial, Hemodynamic Function and Mitochondrial Energetics in Mice with…
04/01/2019 - 03/31/2020 (PI)
Novartis Pharma Corp

Effects of ribose supplementation on cardiac remodeling, exercise capacity and mitochondrial functio
05/19/2015 - 08/18/2016 (PI)
Ribocor, Inc.

Modification of Cardiovascular Proteins by Metabolic Disease
08/15/2010 - 08/14/2015 (PI)
Trustees of Boston University NIH-NHLBI

TOPCAT - Amendment #4 Vascular Ancillary Study
02/01/2009 - 06/30/2014 (PI)
New England Res Inst AtCor Medical, Inc.

09/01/2008 - 06/30/2014 (PI)
New England Res Inst NIH-NHLBI

Oxidative Stress in Myocardial Remodeling and Failure
07/01/2008 - 06/30/2014 (PI)
5R01 HL064750-08

Role Of Oxidative Stress
05/01/1999 - 12/31/2010 (PI)

Showing 10 of 19 results. Show All Results


Yr Title Project-Sub Proj Pubs
2018 Oxidative Stress in Myocardial Remodeling and Failure 5R01HL064750-12 29
2017 Oxidative Stress in Myocardial Remodeling and Failure 5R01HL064750-11 29
2016 Oxidative Stress in Myocardial Remodeling and Failure 5R01HL064750-10 29
2015 Oxidative Stress in Myocardial Remodeling and Failure 2R01HL064750-09A1 29
2011 Oxidative Stress in Myocardial Remodeling and Failure 5R01HL064750-08 29
2010 Oxidative Stress in Myocardial Remodeling and Failure 5R01HL064750-07 29
2009 Oxidative Stress in Myocardial Remodeling and Failure 5R01HL064750-06 29
2008 Oxidative Stress in Myocardial Remodeling and Failure 2R01HL064750-05A1 29
2007 ACTION - A CHF Trial Investigating Outcomes of Exercise 5U01HL068973-06 26
2007 Mechanisms of Oxidant Signaling in Post-MI Remodeling 5R01HL061639-09 46
Showing 10 of 39 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Croteau D, Baka T, Young S, He H, Chambers JM, Qin F, Panagia M, Pimentel DR, Balschi JA, Colucci WS, Luptak I. SGLT2 inhibitor ertugliflozin decreases elevated intracellular sodium, and improves energetics and contractile function in diabetic cardiomyopathy. Biomed Pharmacother. 2023 Apr; 160:114310.View Related Profiles. PMID: 36731341; PMCID: PMC9992115; DOI: 10.1016/j.biopha.2023.114310;
  2. Croteau D, Luptak I, Chambers JM, Hobai I, Panagia M, Pimentel DR, Siwik DA, Qin F, Colucci WS. Effects of Sodium-Glucose Linked Transporter 2 Inhibition With Ertugliflozin on Mitochondrial Function, Energetics, and Metabolic Gene Expression in the Presence and Absence of Diabetes Mellitus in Mice. J Am Heart Assoc. 2021 07 06; 10(13):e019995.View Related Profiles. PMID: 34169737; PMCID: PMC8403324; DOI: 10.1161/JAHA.120.019995;
  3. Goodman JB, Qin F, Morgan RJ, Chambers JM, Croteau D, Siwik DA, Hobai I, Panagia M, Luptak I, Bachschmid M, Tong X, Pimentel DR, Cohen RA, Colucci WS. Redox-Resistant SERCA [Sarco(endo)plasmic Reticulum Calcium ATPase] Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice. Circulation. 2020 12 22; 142(25):2459-2469.View Related Profiles. PMID: 33076678; PMCID: PMC7752816; DOI: 10.1161/CIRCULATIONAHA.120.048183;
  4. Croteau D, Qin F, Chambers JM, Kallick E, Luptak I, Panagia M, Pimentel DR, Siwik DA, Colucci WS. Differential Effects of Sacubitril/Valsartan on Diastolic Function in Mice With Obesity-Related Metabolic Heart Disease. JACC Basic Transl Sci. 2020 Sep; 5(9):916-927.View Related Profiles. PMID: 33015414; PMCID: PMC7524781; DOI: 10.1016/j.jacbts.2020.07.006;
  5. Panagia M, Yang J, Gale E, Wang H, Luptak I, Chen HH, Patel D, Croteau D, Pimentel DR, Bachschmid MM, Colucci WS, Ran C, Sosnovik DE. A novel tracer for in vivo optical imaging of fatty acid metabolism in the heart and brown adipose tissue. Sci Rep. 2020 07 08; 10(1):11209.View Related Profiles. PMID: 32641756; PMCID: PMC7343860; DOI: 10.1038/s41598-020-68065-4;
  6. Panagia M, He H, Baka T, Pimentel DR, Croteau D, Bachschmid MM, Balschi JA, Colucci WS, Luptak I. Increasing mitochondrial ATP synthesis with butyrate normalizes ADP and contractile function in metabolic heart disease. NMR Biomed. 2020 05; 33(5):e4258.View Related Profiles. PMID: 32066202; PMCID: PMC7165026; DOI: 10.1002/nbm.4258;
  7. Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, Levy D, Lewandowski ED, McClung JM, Mochly-Rosen D, O'Brien KD, O'Rourke B, Park JY, Ping P, Sack MN, Sheu SS, Shi Y, Shiva S, Wallace DC, Weiss RG, Vernon HJ, Wong R, Schwartz Longacre L. Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop Circulation. 2019 10 01; 140(14):1205-1216.View Related Profiles. PMID: 31769940; PMCID: PMC6880654; DOI: 10.1161/CIRCULATIONAHA.119.040551;
  8. Luptak I, Morgan R, Baka T, Croteau D, Moverman D, Sarnak H, Kirber M, Bachschmid MM, Colucci WS, Pimentel DR. Genetically targeted fluorescent probes reveal dynamic calcium responses to adrenergic signaling in multiple cardiomyocyte compartments. Int J Biochem Cell Biol. 2019 09; 114:105569.View Related Profiles. PMID: 31299273; PMCID: PMC6832870; DOI: 10.1016/j.biocel.2019.105569;
  9. Luptak I, Croteau D, Valentine C, Qin F, Siwik DA, Remick DG, Colucci WS, Hobai IA. Myocardial Redox Hormesis Protects the Heart of Female Mice in Sepsis. Shock. 2019 07; 52(1):52-60.View Related Profiles. PMID: 30102640
  10. Luptak I, Qin F, Sverdlov AL, Pimentel DR, Panagia M, Croteau D, Siwik DA, Bachschmid MM, He H, Balschi JA, Colucci WS. Energetic Dysfunction Is Mediated by Mitochondrial Reactive Oxygen Species and Precedes Structural Remodeling in Metabolic Heart Disease. Antioxid Redox Signal. 2019 09 01; 31(7):539-549.View Related Profiles. PMID: 31088291; PMCID: PMC6648235; DOI: 10.1089/ars.2018.7707;
Showing 10 of 328 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 327 publications over 43 distinct years, with a maximum of 21 publications in 2000 and 2001


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Heart failure
pathophysiology of heart failure
basic mechanisms of myocardial remodeling
new treatments for heart failure
Contact for Mentoring:

75 E. Newton St Collamore Building
Boston MA 02118
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