Noyan Gokce, MD
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine

MD, Tufts University School of Medicine

My area of expertise is studying disease mechanisms in vascular biology. My recent research has focused on the effect of obesity and inflammation on vascular dysfunction. I have received two R01 grants to support this line of investigation and have additionally received a 5-year PPG project grant with Dr. Ken Walsh. I also have extensive expertise in echocardigraphy and currently collaborate with several investigators in the Department of Medicine.

Active Staff Privileges
Boston Medical Center

2013 Leading Physicians of the World: International Association of Cardiologists
2013-2014 Boston Medical Center: First Prize in Clinical Research
2013 NIH Study Section Special Emphasis Panel: Chair
2012 Boston Medical Center: Collaborator of the Year Award
2012 Boston Medical Center: First Prize in Clinical/Translational Research Competition
2011-2011 Department of Cardiology : I received the 2011 Excellence in Clinical Teaching Award from the Section of Cardiology at Boston M
2011 Boston Medical Center: Excellence in Clinical Teaching Award
2010-2010 Department of Evans/Medicine : Work presented from our laboratory by Dr. Melissa Farb received FIRST PRIZE in clinical research in
2010 Boston University Evans Day Intramural Research Competition: First Prize
2006 Boston Medical Center: Excellence in Clinical Teaching Award
2003 America’s Registry of Outstanding Professionals
2000-2005 National Institutes of Health: Research Career Development Award (K-23)
1998-2000 National Institutes of Health: Individual National Research Service Award (NRSA)
1997 New England Research Competition and Award Program: Fellow Finalist
1997-1998 American Heart Association: New England Affiliate Fellowship Award

Identifying a novel regulatory pathway of vascular function in obesity
06/01/2018 - 05/31/2022 (PI)
NIH/National Heart, Lung, and Blood Institute

Anti-Angiogenic Mechanisms in Human Obesity
11/14/2014 - 10/31/2019 (Multi-PI)
PI: Noyan Gokce, MD
NIH/National Heart, Lung, and Blood Institute

Adipose Inflammation, Mitochondrial & Endothelial Phenotypes in Obesity
07/01/2016 - 06/30/2018 (PI)
NIH/National Heart, Lung, and Blood Institute

Metabolic Control of Endothelial Cell Phenotype
09/30/2005 - 02/28/2017 (PI of Sub-Project / SP)
PI: Kenneth Walsh, PhD
NIH/National Heart, Lung, and Blood Institute

Adipose Inflammation, Mitochondrial Function & Endothelial Phenotypes in Obesity
07/05/2012 - 06/30/2016 (PI)
NIH/National Heart, Lung, and Blood Institute

Contribution of Myeloperoxidasae Activity to Endothelial Dysfunction in Adipose Tissue Arterioles Isolated from Obese Human Subjects
07/01/2012 - 06/30/2015 (PI)
Pfizer, Inc.

Inflammation and Vascular Dysfunction in Obesity
02/20/2007 - 01/31/2013 (PI)
NIH/National Heart, Lung, and Blood Institute

Obesity, Adipocytokines, and Endothelial Dysfunction
08/15/2003 - 07/31/2009 (PI)

Endothelial Dysfunction
09/01/2000 - 07/31/2006 (PI)
5 K23 HL004425-05

Predictive value of Endothelial Disfunction
07/01/2003 - 06/30/2005 (PI)
American Society of Echocardiography

Oxidative Stress And Endotheli
05/30/1998 - 05/29/2001 (PI)
1 F32 HL09894-03

Yr Title Project-Sub Proj Pubs
2019 Anti-Angiogenic Mechanisms in Human Obesity 5R01HL126141-05 14
2019 Anti-Angiogenic Mechanisms in Human Obesity 5R01HL126141-05 14
2018 Identifying a novel regulatory pathway of vascular function in obesity 1R01HL140836-01A1
2018 Anti-Angiogenic Mechanisms in Human Obesity 5R01HL126141-04 14
2017 Anti-Angiogenic Mechanisms in Human Obesity 5R01HL126141-03 14
2016 Anti-Angiogenic Mechanisms in Human Obesity 5R01HL126141-02 14
2016 Adipose inflammation, mitochondrial function & endothelial phenotypes in obesity 4R01HL114675-05 19
2015 Anti-Angiogenic Mechanisms in Human Obesity 1R01HL126141-01 14
2015 Adipose inflammation, mitochondrial function & endothelial phenotypes in obesity 5R01HL114675-04 19
Showing 10 of 36 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Gopal DM, Ayalon N, Wang YC, Siwik D, Sverdlov A, Donohue C, Perez A, Downing J, Apovian C, Silva V, Panagia M, Kolachalama V, Ho JE, Liang CS, Gokce N, Colucci WS. Galectin-3 Is Associated With Stage B Metabolic Heart Disease and Pulmonary Hypertension in Young Obese Patients. J Am Heart Assoc. 2019 Apr 02; 8(7):e011100.View Related Profiles. PMID: 30929550.
  2. Ngo DTM, Sverdlov AL, Karki S, Macartney-Coxson D, Stubbs RS, Farb MG, Carmine B, Hess DT, Colucci WS, Gokce N. Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity. Am J Physiol Endocrinol Metab. 2019 Feb 01; 316(2):E168-E177.View Related Profiles. PMID: 30576243.
  3. Zuriaga MA, Fuster JJ, Farb MG, MacLauchlan S, Bretón-Romero R, Karki S, Hess DT, Apovian CM, Hamburg NM, Gokce N, Walsh K. Activation of non-canonical WNT signaling in human visceral adipose tissue contributes to local and systemic inflammation. Sci Rep. 2017 Dec 11; 7(1):17326.View Related Profiles. PMID: 29229927; DOI: 10.1038/s41598-017-17509-5;.
  4. Farb MG, Park SY, Karki S, Gokce N. Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy. J Vis Exp. 2017 Sep 29; (127).View Related Profiles. PMID: 28994775.
  5. Zuriaga MA, Fuster JJ, Maclauchlan S, Gokce N, Walsh K. Coordinated activation of WNT/planar cell polarity signaling in inflamed visceral fat of obese individuals. Atherosclerosis. 2017 Aug; 263:e8.View Related Profiles. PMID: 29366230.
  6. Zuriaga MA, Fuster JJ, Gokce N, Walsh K. Humans and Mice Display Opposing Patterns of "Browning" Gene Expression in Visceral and Subcutaneous White Adipose Tissue Depots. Front Cardiovasc Med. 2017; 4:27.View Related Profiles. PMID: 28529941.
  7. Karki S, Ngo DTM, Farb MG, Park SY, Saggese SM, Hamburg NM, Carmine B, Hess DT, Walsh K, Gokce N. WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-A165b in obese humans. Am J Physiol Heart Circ Physiol. 2017 Jul 01; 313(1):H200-H206.View Related Profiles. PMID: 28411232; DOI: 10.1152/ajpheart.00776.2016;.
  8. Farb MG, Karki S, Park SY, Saggese SM, Carmine B, Hess DT, Apovian C, Fetterman JL, Bretón-Romero R, Hamburg NM, Fuster JJ, Zuriaga MA, Walsh K, Gokce N. WNT5A-JNK regulation of vascular insulin resistance in human obesity. Vasc Med. 2016 Dec; 21(6):489-496.View Related Profiles. PMID: 27688298.
  9. Fuster JJ, Ouchi N, Gokce N, Walsh K. Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease. Circ Res. 2016 May 27; 118(11):1786-807.View Related Profiles. PMID: 27230642; PMCID: PMC4887147; DOI: 10.1161/CIRCRESAHA.115.306885;.
  10. Fetterman JL, Holbrook M, Westbrook DG, Brown JA, Feeley KP, Bretón-Romero R, Linder EA, Berk BD, Weisbrod RM, Widlansky ME, Gokce N, Ballinger SW, Hamburg NM. Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease. Cardiovasc Diabetol. 2016 Mar 31; 15:53.View Related Profiles. PMID: 27036979; PMCID: PMC4818501; DOI: 10.1186/s12933-016-0372-y;.
Showing 10 of 84 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 84 publications over 23 distinct years, with a maximum of 8 publications in 2003

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Cardiovascular Diseases
Vascular biology
Metabolic Disease
Weight loss
Cardiac Imaging

Available to Mentor as: (Review Mentor Role Definitions):
  • Research / Scholarly Mentor
Contact for Mentoring:

75 E. Newton St Collamore Building
Boston MA 02118
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