Kenneth Walsh, PhD
Adjunct Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine

PhD, University of California, Berkeley



My laboratory examines molecular events that drive cardiovascular cell growth, differentiation and apoptosis. Over the past decade my laboratory has been investigating mechanisms of inter-tissue communication and how these systems contribute to physiological versus pathological tissue growth in the cardiovascular system.

Director of Whitaker Cardiovascular Institute
Boston University School of Medicine


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences



2011 Distinguished Investigator of the American Heart Association
2008-2018 Aram V. Chobanian Distinguished Professor of Medicine
2003-2013 National Advisory Council on Aging, National Institute on Aging: Method to Extend Research in Time (MERIT) Award
2001-2018 American Heart Association: Fellow, Council on Basic Cardiovascular Research
1997 BGSU: Chemistry Alumnus of the Year
1996-1999 Gencell Investigator
1995 Case Western Reserve University: Division of Nephrology Visiting Professor
1993 Molecular and Cellular Biology of the Vascular Wall: AHA Young Investigator Award
1993 AHA Council on Arteriosclerosis: Irvine F. Page Young Investigator Award
1990-1995 Established Investigator of the American Heart Association
1990-1992 Life and Health Insurance Medical Research Fund Award
1989-1993 Mathers Foundation Young Investigator
1988-1989 National Research Service Award Fellowship
1987-1988 National Research Service Award Fellowship
1986-1987 Muscular Dystrophy Association: Postdoctoral Fellowship


Somatic TET2 mutations in cardiac remodeling
07/15/2017 - 06/30/2021 (PI)
NIH/National Heart, Lung, and Blood Institute
1R01HL138014-01

Inflammatory Pathways in Aortic Aneurysms
04/01/2016 - 03/31/2020 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL132564-03

Inflammatory Wnt signaling in ischemic myocardium
01/01/2016 - 12/31/2019 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL131006-03

Anti-Angiogenic Mechanisms in Human Obesity
11/14/2014 - 10/31/2019 (Multi-PI)
PI: Kenneth Walsh, PhD
NIH/National Heart, Lung, and Blood Institute
5R01HL126141-04

Myokine Control of Hepatic Steatosis
09/15/2016 - 05/31/2018 (PI)
NIH/National Institute on Aging
5R21AG052160-02

Follistatin-like protein 1 in cardiac and systemic metabolism
04/01/2016 - 03/31/2018 (PI)
Temple University of the Commonwealth System of Higher Education NIH NHLBI
5R01HL129120-02

Cardio-metabolic actions of FSTL1
03/28/2013 - 09/30/2017 (PI)
Takeda Pharmaceuticals North America, Inc.


Paracrine Regulation of Heart Failure
07/01/2016 - 06/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
4R01HL116591-04

Mitochondrial Dynamics and Cardiac Remodeling
06/01/2016 - 05/31/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
4R01HL120160-04

Metabolic Control of Endothelial Cell Phenotype
09/30/2005 - 02/28/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
5P01HL081587-10

Showing 10 of 32 results. Show All Results

QUANTSTUDIO 12K FLEX OPEN ARRAY REAL-TIME PCR SYSTEM
05/15/2017 - 05/14/2018 (PI)
NIH-OD
1S10OD023663-01



Yr Title Project-Sub Proj Pubs
2018 Follistatin-like protein 1 in cardiac and systemic metabolism 5R01HL129120-03
2018 Inflammatory Pathways in Aortic Aneurysms 5R01HL132564-03
2018 Inflammatory Wnt signaling in ischemic myocardium 5R01HL131006-03 4
2018 Inflammatory Wnt signaling in ischemic myocardium 7R01HL131006-04 4
2018 Anti-Angiogenic Mechanisms in Human Obesity 5R01HL126141-04 4
2017 Somatic TET2 mutations in cardiac remodeling 1R01HL138014-01
2017 QUANTSTUDIO 12K FLEX OPEN ARRAY REAL-TIME PCR SYSTEM 1S10OD023663-01
2017 Follistatin-like protein 1 in cardiac and systemic metabolism 5R01HL129120-02
2017 Inflammatory Pathways in Aortic Aneurysms 5R01HL132564-02
2017 Inflammatory Wnt signaling in ischemic myocardium 5R01HL131006-02 4
Showing 10 of 135 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Maruyama S, Wu CL, Yoshida S, Zhang D, Li PH, Wu F, Parker Duffen J, Yao R, Jardin B, Adham IM, Law R, Berger J, Di Marchi R, Walsh K. Relaxin Family Member Insulin-Like Peptide 6 Ameliorates Cardiac Fibrosis and Prevents Cardiac Remodeling in Murine Heart Failure Models. J Am Heart Assoc. 2018 Jun 10; 7(12).View Related Profiles. PMID: 29887522.
     
  2. Sano S, Oshima K, Wang Y, Katanasaka Y, Sano M, Walsh K. CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease. Circ Res. 2018 Jul 20; 123(3):335-341. PMID: 29728415.
     
  3. Sano S, Oshima K, Wang Y, MacLauchlan S, Katanasaka Y, Sano M, Zuriaga MA, Yoshiyama M, Goukassian D, Cooper MA, Fuster JJ, Walsh K. Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1ß/NLRP3 Inflammasome. J Am Coll Cardiol. 2018 Feb 27; 71(8):875-886.View Related Profiles. PMID: 29471939.
     
  4. Fuster JJ, Walsh K. Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease. Circ Res. 2018 Feb 02; 122(3):523-532.View Related Profiles. PMID: 29420212.
     
  5. Seki M, Powers JC, Maruyama S, Zuriaga MA, Wu CL, Kurishima C, Kim L, Johnson J, Poidomani A, Wang T, Muñoz E, Rajan S, Park JY, Walsh K, Recchia FA. Acute and Chronic Increases of Circulating FSTL1 Normalize Energy Substrate Metabolism in Pacing-Induced Heart Failure. Circ Heart Fail. 2018 Jan; 11(1):e004486.View Related Profiles. PMID: 29317401.
     
  6. Zuriaga MA, Fuster JJ, Farb MG, MacLauchlan S, Bretón-Romero R, Karki S, Hess DT, Apovian CM, Hamburg NM, Gokce N, Walsh K. Activation of non-canonical WNT signaling in human visceral adipose tissue contributes to local and systemic inflammation. Sci Rep. 2017 Dec 11; 7(1):17326.View Related Profiles. PMID: 29229927; DOI: 10.1038/s41598-017-17509-5;.
     
  7. Neppl RL, Wu CL, Walsh K. lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy. J Cell Biol. 2017 Nov 06; 216(11):3497-3507.View Related Profiles. PMID: 28855249.
     
  8. Fuster JJ, Maclauchlan S, Zuriaga MA, Polackal MN, Walsh K. Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis in hyperlipidemic mice. Atherosclerosis. 2017 Aug; 263:e14.View Related Profiles. PMID: 29365557.
     
  9. Zuriaga MA, Fuster JJ, Maclauchlan S, Gokce N, Walsh K. Coordinated activation of WNT/planar cell polarity signaling in inflamed visceral fat of obese individuals. Atherosclerosis. 2017 Aug; 263:e8.View Related Profiles. PMID: 29366230.
     
  10. MacLauchlan S, Zuriaga MA, Fuster JJ, Cuda CM, Jonason J, Behzadi F, Duffen JP, Haines GK, Aprahamian T, Perlman H, Walsh K. Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis. Arthritis Res Ther. 2017 Jul 19; 19(1):166.View Related Profiles. PMID: 28724439; DOI: 10.1186/s13075-017-1375-0;.
     
Showing 10 of 115 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 115 publications over 22 distinct years, with a maximum of 18 publications in 2014

YearPublications
19891
19961
19971
19982
19993
20004
20021
20044
20054
20061
20071
20085
200911
20109
20115
20122
201310
201418
201510
20166
201711
20185
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

apoptosis
cardiovascular system
cell differentiation
cell growth
inter-tissue communication
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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