Shakun Karki, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Cardiovascular Medicine

PhD, Boston University School of Medicine
MS, University of New Hampshire

Obesity represents the largest preventable health care problem in the United States. More than two third of deaths related to obesity worldwide are from cardiovascular cause. Pathological mechanisms that connect obesity with cardiovascular are incompletely understood. Dr. Karki's research interests focuses on understanding the mechanisms of obesity induced diseases, including endothelial and vascular dysfunction, insulin-resistance and cardiovascular disease.

Boston University
Whitaker Cardiovascular Institute

FSP27 regulation of vascular function in human obesity
07/01/2018 - 06/30/2023 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Ahmed B, Farb MG, Karki S, D'Alessandro S, Edwards NM, Gokce N. Pericardial Adipose Tissue Thrombospondin-1 Associates With Antiangiogenesis in Ischemic Heart Disease. Am J Cardiol. 2024 Jan 01; 210:201-207.View Related Profiles. PMID: 37863116; PMCID: PMC10842123; DOI: 10.1016/j.amjcard.2023.09.104;
  2. Balakrishnan B, Gupta A, Basri R, Sharma VM, Slayton M, Gentner K, Becker CC, Karki S, Muturi H, Najjar SM, Loria AS, Gokce N, Puri V. Endothelial-Specific Expression of CIDEC Improves High-Fat Diet-Induced Vascular and Metabolic Dysfunction. Diabetes. 2023 Jan 01; 72(1):19-32.View Related Profiles. PMID: 36256836; PMCID: PMC9797323; DOI: 10.2337/db22-0294;
  3. Gupta A, Balakrishnan B, Karki S, Slayton M, Jash S, Banerjee S, Grahn THM, Jambunathan S, Disney S, Hussein H, Kong D, Lowell BB, Natarajan P, Reddy UK, Gokce N, Sharma VM, Puri V. Human CIDEC transgene improves lipid metabolism and protects against high-fat diet-induced glucose intolerance in mice. J Biol Chem. 2022 Sep; 298(9):102347.View Related Profiles. PMID: 35963433; PMCID: PMC9472082; DOI: 10.1016/j.jbc.2022.102347;
  4. Gokce N, Karki S, Dobyns A, Zizza E, Sroczynski E, Palmisano JN, Mazzotta C, Hamburg NM, Pernar LI, Carmine B, Carter CO, LaValley M, Hess DT, Apovian CM, Farb MG. Association of Bariatric Surgery With Vascular Outcomes. JAMA Netw Open. 2021 07 01; 4(7):e2115267.View Related Profiles. PMID: 34251443; PMCID: PMC8276087; DOI: 10.1001/jamanetworkopen.2021.15267;
  5. Mazzotta C, Basu S, Gower AC, Karki S, Farb MG, Sroczynski E, Zizza E, Sarhan A, Pande AN, Walsh K, Dobrilovic N, Gokce N. Perivascular Adipose Tissue Inflammation in Ischemic Heart Disease. Arterioscler Thromb Vasc Biol. 2021 03; 41(3):1239-1250.View Related Profiles. PMID: 33504180; PMCID: PMC7904602; DOI: 10.1161/ATVBAHA.120.315865;
  6. Karki S. FSP27 and Links to Obesity and Diabetes Mellitus. Curr Obes Rep. 2019 Sep; 8(3):255-261. PMID: 30919313; PMCID: PMC6661191; DOI: 10.1007/s13679-019-00343-3;
  7. Karki S, Farb MG, Sharma VM, Jash S, Zizza EJ, Hess DT, Carmine B, Carter CO, Pernar LI, Apovian CM, Puri V, Gokce N. Fat-Specific Protein 27 Regulation of Vascular Function in Human Obesity. J Am Heart Assoc. 2019 06 04; 8(11):e011431.View Related Profiles. PMID: 31433737; PMCID: PMC6585348; DOI: 10.1161/JAHA.118.011431;
  8. Frenquelli M, Caridi N, Antonini E, Storti F, Viganò V, Gaviraghi M, Occhionorelli M, Bianchessi S, Bongiovanni L, Spinelli A, Marcatti M, Belloni D, Ferrero E, Karki S, Brambilla P, Martinelli-Boneschi F, Colla S, Ponzoni M, DePinho RA, Tonon G. The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation. Leukemia. 2020 01; 34(1):257-270. PMID: 31148590; DOI: 10.1038/s41375-019-0486-9;
  9. Ngo DTM, Sverdlov AL, Karki S, Macartney-Coxson D, Stubbs RS, Farb MG, Carmine B, Hess DT, Colucci WS, Gokce N. Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity. Am J Physiol Endocrinol Metab. 2019 02 01; 316(2):E168-E177.View Related Profiles. PMID: 30576243; PMCID: PMC6397365; DOI: 10.1152/ajpendo.00227.2018;
  10. Zuriaga MA, Fuster JJ, Farb MG, MacLauchlan S, Bretón-Romero R, Karki S, Hess DT, Apovian CM, Hamburg NM, Gokce N, Walsh K. Activation of non-canonical WNT signaling in human visceral adipose tissue contributes to local and systemic inflammation. Sci Rep. 2017 12 11; 7(1):17326.View Related Profiles. PMID: 29229927; PMCID: PMC5725530; DOI: 10.1038/s41598-017-17509-5;
Showing 10 of 24 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 24 publications over 12 distinct years, with a maximum of 3 publications in 2013 and 2014 and 2017 and 2019


2018-2022 NIH/National Institute of Diabetes and Digestive and Kidney Diseases : FSP27 regulation of vascular function in human obesity.
2017 Boston University School of Medicine: Faculty Development Diversity Grant
2014 Boston University Medical School: Evans Day-Best Clinical Research, Runner up
2013 Postdoctoral: Whitaker Cardiovascular Institute, Boston University: T32 HL07224
2011-2012 Training Cardiovascular Biology: Predoctoral: 5T32HL007969-02
2001-2001 University of New Hampshire: Summer Teaching Fellow
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Obesity, endothelial andvascular dysfunction, insulin-resistance, type 2 diabetes, CVD
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72 E. Concord St Evans Building
Boston MA 02118
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