Shakun Karki, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine

PhD, Boston University School of Medicine
MS, University of New Hampshire




Obesity represents the largest preventable health care problem in the United States. More than two third of deaths related to obesity worldwide are from cardiovascular cause. Pathological mechanisms that connect obesity with cardiovascular are incompletely understood. Dr. Karki's research interests focuses on understanding the mechanisms of obesity induced diseases, including endothelial and vascular dysfunction, insulin-resistance and cardiovascular disease.

Member
Boston University
Whitaker Cardiovascular Institute



2018-2022 NIH/National Institute of Diabetes and Digestive and Kidney Diseases : FSP27 regulation of vascular function in human obesity.
2017 Boston University School of Medicine: Faculty Development Diversity Grant
2014 Boston University Medical School: Evans Day-Best Clinical Research, Runner up
2013 Postdoctoral: Whitaker Cardiovascular Institute, Boston University: T32 HL07224
2011-2012 Training Cardiovascular Biology: Predoctoral: 5T32HL007969-02
2001-2001 University of New Hampshire: Summer Teaching Fellow


FSP27 regulation of vascular function in human obesity
07/01/2018 - 06/30/2022 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5K01DK114897-03



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Karki S. FSP27 and Links to Obesity and Diabetes Mellitus. Curr Obes Rep. 2019 Sep; 8(3):255-261. PMID: 30919313
     
  2. Karki S, Farb MG, Sharma VM, Jash S, Zizza EJ, Hess DT, Carmine B, Carter CO, Pernar LI, Apovian CM, Puri V, Gokce N. Fat-Specific Protein 27 Regulation of Vascular Function in Human Obesity. J Am Heart Assoc. 2019 06 04; 8(11):e011431.View Related Profiles. PMID: 31433737
     
  3. Frenquelli M, Caridi N, Antonini E, Storti F, Viganò V, Gaviraghi M, Occhionorelli M, Bianchessi S, Bongiovanni L, Spinelli A, Marcatti M, Belloni D, Ferrero E, Karki S, Brambilla P, Martinelli-Boneschi F, Colla S, Ponzoni M, DePinho RA, Tonon G. The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation. Leukemia. 2020 01; 34(1):257-270. PMID: 31148590; DOI: 10.1038/s41375-019-0486-9;
     
  4. Ngo DTM, Sverdlov AL, Karki S, Macartney-Coxson D, Stubbs RS, Farb MG, Carmine B, Hess DT, Colucci WS, Gokce N. Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity. Am J Physiol Endocrinol Metab. 2019 02 01; 316(2):E168-E177.View Related Profiles. PMID: 30576243
     
  5. Zuriaga MA, Fuster JJ, Farb MG, MacLauchlan S, Bretón-Romero R, Karki S, Hess DT, Apovian CM, Hamburg NM, Gokce N, Walsh K. Activation of non-canonical WNT signaling in human visceral adipose tissue contributes to local and systemic inflammation. Sci Rep. 2017 12 11; 7(1):17326.View Related Profiles. PMID: 29229927; DOI: 10.1038/s41598-017-17509-5;
     
  6. Farb MG, Park SY, Karki S, Gokce N. Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy. J Vis Exp. 2017 Sep 29; (127).View Related Profiles. PMID: 28994775
     
  7. Karki S, Ngo DTM, Farb MG, Park SY, Saggese SM, Hamburg NM, Carmine B, Hess DT, Walsh K, Gokce N. WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-A165b in obese humans. Am J Physiol Heart Circ Physiol. 2017 Jul 01; 313(1):H200-H206.View Related Profiles. PMID: 28411232; DOI: 10.1152/ajpheart.00776.2016;
     
  8. Farb MG, Karki S, Park SY, Saggese SM, Carmine B, Hess DT, Apovian C, Fetterman JL, Bretón-Romero R, Hamburg NM, Fuster JJ, Zuriaga MA, Walsh K, Gokce N. WNT5A-JNK regulation of vascular insulin resistance in human obesity. Vasc Med. 2016 Dec; 21(6):489-496.View Related Profiles. PMID: 27688298
     
  9. Karki S, Farb MG, Myers S, Apovian C, Hess DT, Gokce N. Effect of Bariatric Weight Loss on the Adipose Lipolytic Transcriptome in Obese Humans. Mediators Inflamm. 2015; 2015:106237.View Related Profiles. PMID: 26663986; DOI: 10.1155/2015/106237;
     
  10. Karki S, Farb MG, Ngo DT, Myers S, Puri V, Hamburg NM, Carmine B, Hess DT, Gokce N. Forkhead box O-1 modulation improves endothelial insulin resistance in human obesity. Arterioscler Thromb Vasc Biol. 2015 Jun; 35(6):1498-506.View Related Profiles. PMID: 25908760; PMCID: PMC4441602; DOI: 10.1161/ATVBAHA.114.305139;
     
Showing 10 of 19 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 19 publications over 9 distinct years, with a maximum of 3 publications in 2013 and 2014 and 2017 and 2019

YearPublications
20071
20112
20133
20143
20152
20161
20173
20181
20193
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Obesity, endothelial andvascular dysfunction, insulin-resistance, type 2 diabetes, CVD
Contact for Mentoring:

72 E. Concord St Evans Building
Boston MA 02118
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