Boston University Alzheimer's Disease Research Center
08/15/2021 - 06/30/2026 (Key Person)
PI: Ann C. McKee, MD
NIH/National Institute on Aging
5P30AG072978-02

The A45 Study: Combination anti-amyloid therapy for preclinical Alzheimer's disease
09/30/2019 - 05/31/2024 (Subcontract PI)
University of Southern California NIH NIA
1R01AG061848-01

Protocol number BAN2401-G000-303: AHEAD 3-45 Study: A Placebo-Controlled, Double-Blind, Parallel-Treatment Arm, 216 Week Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Subject
01/01/2020 - 12/31/2023 (Subcontract PI)
University of Southern California Eisai, Inc


Leveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD)
03/15/2019 - 11/30/2023 (Subcontract PI)
Icahn School of Medicine at Mount Sinai NIH NIA
5R01AG061028-05

Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium
09/30/2021 - 08/31/2023 (Subcontract PI)
Vanderbilt University Medical Center NIH NIA
5U24AG074855-02

Leveraging the Framingham Study to Investigate Relationships between Traumatic Brain Injury, Military Service, Alzheimer's Disease and Related Dementias
09/01/2018 - 08/31/2023 (PI)
Department of Defense/Army Medical Research Acquisition Activity


The A3 Study: Ante-Amyloid prevention of Alzheimer's disease
06/01/2019 - 04/30/2023 (Subcontract PI)
University of Southern California NIH NIA
5R01AG061848-03

ADNI Psychometrics
12/01/2017 - 03/31/2023 (Subcontract PI)
University of Washington NIH NIA
5R01AG029672-10

Genetic Architecture of Memory and Executive Functioning in Alzheimer's Disease
09/01/2014 - 05/31/2019 (Co-Investigator)
University of Washington NIH NIA
5R01AG042437-04

Genetic and Neuropsychological Heterogeneity in Alzheimer's Disease
08/15/2014 - 05/31/2019 (PI)
NIH/National Institute on Aging
5K23AG046377-05

Showing 10 of 12 results. Show All Results

1. Chung J, Sahelijo N, Maruyama T, Hu J, Panitch R, Xia W, Mez J, Stein TD, Saykin AJ, Takeyama H, Farrer LA, Crane PK, Nho K, Jun GR. Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles. Alzheimers Dement. 2023 May 11.View Related Profiles.

   Jun, Gyungah
   Mez, Jesse
   Farrer, Lindsay
   Stein, Thor
   

   PMID: 37166019
2. Fang Y, Doyle MF, Chen J, Mez J, Satizabal CL, Alosco ML, Qiu WQ, Lunetta KL, Murabito JM. Circulating immune cell phenotypes are associated with age, sex, CMV, and smoking status in the Framingham Heart Study offspring participants. Aging (Albany NY). 2023 Apr 27; 15.View Related Profiles.

   Satizabal, Claudia
   Mez, Jesse
   Murabito, Joanne
   Lunetta, Kathryn
   Alosco, Michael
   Fang, Yuan
   

   PMID: 37116193
3. Groechel RC, Tripodis Y, Alosco ML, Mez J, Qiu WQ, Mercier G, Goldstein L, Budson AE, Kowall NW, Killiany RJ. Annualized changes in rate of amyloid deposition and neurodegeneration are greater in participants who become amyloid positive than those who remain amyloid negative. Neurobiol Aging. 2023 Jul; 127:33-42.View Related Profiles.

   Budson, Andrew
   Mercier, Gustavo
   Mez, Jesse
   Alosco, Michael
   Kowall, Neil
   Tripodis, Yorghos
   

   PMID: 37043881
4. Labadorf A, Agus F, Aytan N, Cherry J, Mez J, McKee A, Stein TD. Inflammation and neuronal gene expression changes differ in early versus late chronic traumatic encephalopathy brain. BMC Med Genomics. 2023 Mar 09; 16(1):49.View Related Profiles.

   Labadorf, Adam
   McKee, Ann
   Mez, Jesse
   Cherry, Jonathan
   Aytan, Nurgul
   Stein, Thor
   

   PMID: 36895005; PMCID: PMC9996917; DOI: 10.1186/s12920-023-01471-5;
5. Alosco ML, Ly M, Mosaheb S, Saltiel N, Uretsky M, Tripodis Y, Martin B, Palmisano J, Delano-Wood L, Bondi MW, Meng G, Xia W, Daley S, Goldstein LE, Katz DI, Dwyer B, Daneshvar DH, Nowinski C, Cantu RC, Kowall NW, Stern RA, Alvarez VE, Mez J, Huber BR, McKee AC, Stein TD. Decreased myelin proteins in brain donors exposed to football-related repetitive head impacts. Brain Commun. 2023; 5(2):fcad019.View Related Profiles.

   McKee, Ann
   Huber, Bertrand
   Dwyer, Brigid
   Nowinski, Christopher
   Daneshvar, Daniel
   Katz, Douglas
   Mez, Jesse
   Goldstein, Lee
   Alosco, Michael
   Kowall, Neil
   Stern, Robert
   Stein, Thor
   Alvarez, Victor
   Tripodis, Yorghos
   

   PMID: 36895961; PMCID: PMC9990992; DOI: 10.1093/braincomms/fcad019;
6. McKee AC, Stein TD, Huber BR, Crary JF, Bieniek K, Dickson D, Alvarez VE, Cherry JD, Farrell K, Butler M, Uretsky M, Abdolmohammadi B, Alosco ML, Tripodis Y, Mez J, Daneshvar DH. Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts. Acta Neuropathol. 2023 Apr; 145(4):371-394.View Related Profiles.

   McKee, Ann
   Huber, Bertrand
   Daneshvar, Daniel
   Mez, Jesse
   Cherry, Jonathan
   Alosco, Michael
   Stein, Thor
   Alvarez, Victor
   Tripodis, Yorghos
   

   PMID: 36759368; PMCID: PMC10020327; DOI: 10.1007/s00401-023-02540-w;
7. Nicks R, Clement NF, Alvarez VE, Tripodis Y, Baucom ZH, Huber BR, Mez J, Alosco ML, Aytan N, Cherry JD, Cormier KA, Kubilius C, Mathias R, Svirsky SE, Pothast MJ, Hildebrandt AM, Chung J, Han X, Crary JF, McKee AC, Frosch MP, Stein TD. Repetitive head impacts and chronic traumatic encephalopathy are associated with TDP-43 inclusions and hippocampal sclerosis. Acta Neuropathol. 2023 Apr; 145(4):395-408.View Related Profiles.

   McKee, Ann
   Huber, Bertrand
   Mez, Jesse
   Cherry, Jonathan
   Alosco, Michael
   Aytan, Nurgul
   Stein, Thor
   Alvarez, Victor
   Tripodis, Yorghos
   

   PMID: 36681782; DOI: 10.1007/s00401-023-02539-3;
8. Hwang PH, Ang TFA, De Anda-Duran I, Liu X, Liu Y, Gurnani A, Mez J, Auerbach S, Joshi P, Yuan J, Devine S, Au R, Liu C. Examination of potentially modifiable dementia risk factors across the adult life course: The Framingham Heart Study. Alzheimers Dement. 2023 Jan 19.View Related Profiles.

   Gurnani, Ashita
   Liu, Chunyu
   Mez, Jesse
   Yuan, Jin
   Hwang, Phillip
   Au, Rhoda
   Auerbach, Sanford
   Devine, Sherral
   Ang, Ting Fang Alvin
   

   PMID: 36656649
9. Wang Y, Huang J, Ang TFA, Zhu Y, Tao Q, Mez J, Alosco M, Denis GV, Belkina A, Gurnani A, Ross M, Gong B, Han J, Lunetta KL, Stein TD, Au R, Farrer LA, Zhang X, Qiu WQ. Circulating Endothelial Progenitor Cells Reduce the Risk of Alzheimer's Disease. medRxiv. 2023 Jan 18.View Related Profiles.

   Belkina, Anna
   Gurnani, Ashita
   Denis, Gerald
   Mez, Jesse
   Lunetta, Kathryn
   Farrer, Lindsay
   Alosco, Michael
   Au, Rhoda
   Stein, Thor
   

   PMID: 36711847; PMCID: PMC9882408; DOI: 10.1101/2023.01.16.23284571;
10. Alosco ML, Barr WB, Banks SJ, Wethe JV, Miller JB, Pulukuri SV, Culhane J, Tripodis Y, Adler CH, Balcer LJ, Bernick C, Mariani ML, Cantu RC, Dodick DW, McClean MD, Au R, Mez J, Turner RW, Palmisano JN, Martin B, Hartlage K, Cummings JL, Reiman EM, Shenton ME, Stern RA. Neuropsychological test performance of former American football players. Alzheimers Res Ther. 2023 Jan 03; 15(1):1.View Related Profiles.

    Mez, Jesse
    Alosco, Michael
    McClean, Michael
    Au, Rhoda
    Stern, Robert
    Tripodis, Yorghos
    

    PMID: 36597138; PMCID: PMC9808953; DOI: 10.1186/s13195-022-01147-9;

Showing 10 of 123 results. Show More

For NHL Players, More Fighting on the Ice Is Linked to Shorter Lives

NHL commissioner disputes link between hockey and CTE brain disease

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Can Football Fans Watch with a Clear Conscience?

New research suggests intensity of hits in sports, not years played, may be better predictor of devastating brain damage

Genetic Variation May Explain Differences in CTE Risk After Repetitive Head Impact

Genetic variant may increase risk for CTE severity among older individuals with repetitive head impacts

Boston University CTE study: Genes may play major role in CTE severity

Former football pros die at a faster rate than baseball veterans—and the reasons are surprising

More Years Playing Hockey, Higher Odds for CTE Linked to Head Injury

More Years of Ice Hockey Play Tied to Higher CTE Risk

Boston University scientists making progress in CTE research

BU scientists getting closer to diagnosing CTE in Living people using MRI

Boston University scientists getting closer to diagnosing CTE in living people using MRI

MRI Might Spot Concussion-Linked CTE in Living Patients

MRI Might Spot Concussion-Linked CTE in Living Patient

BU Researchers: CTE Study Offers Potential Path For Diagnosing The Brain Disease Before Death

Each Year You Play Football Increases Your Chances of Developing CTE by 30 Percent

Soccer Heading Has Greater Impact on Memory in ApoE4 Carriers

Soccer Headers Might Be More Risky for APOE4 Genotype Carriers

Pointed ‘Tackle Can Wait’ TV ad hits amid sobering new CTE study’s stats

Every 2.6 Years of Playing American Football Doubles Risk of Devastating Brain Disease

NFL Stars' Risk of Developing the Degenerative Brain Disease CTE Soars by a THIRD Every Year They Play, Study Finds

Scary: Study Finds Every Year of Tackle Football Raises Chances of CTE 30%

NFL stars’ risk of developing the degenerative brain disease CTE soars by a THIRD every year they play, study finds

CTE Risk Goes Up 30% For Each Year Of Playing Football

BU Research Finds Link Between Playing Football and CTE

CTE Risk in Football Players Doubles Every Five Years, New Study Finds

CTE Risk More Than Doubles after Just Three Years of Playing Football

CTE Risk, Severity Increases With Years Playing Football, Study Shows

College Football Season Is Here. Will Universities Continue To Ignore The Risk Of Brain Damage?

New Jersey Unveils New Limits on High School Football Practices

Cannabis Studied to Treat Conditions from Football-Related Brain Trauma

Why We Still Don’t Know How Many NFL Players Have CTE

What's the Risk of Chronic Traumatic Encephalopathy for NFL Players?

Some People May Have Increased CTE Risk Because Of Their Genes

Why Some People’s CTE Symptoms Are More Severe Than Others

Why do some people get CTE? It may be in their genes

Why Don't All Football Players Develop CTE? It May Be Genetics

MED Researchers: Youth Football Linked to Earlier Brain Problems