Boston University Alzheimer's Disease Research Center
08/15/2021 - 06/30/2026 (Key Person)
PI: Ann C. McKee, MD
NIH/National Institute on Aging
5P30AG072978-02

Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium
09/30/2021 - 08/31/2023 (Subcontract PI)
Vanderbilt University Medical Center NIH NIA
5U24AG074855-02

ADNI Psychometrics
12/01/2017 - 03/31/2023 (Subcontract PI)
University of Washington NIH NIA
5R01AG029672-10

Leveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD)
03/15/2019 - 11/30/2022 (Subcontract PI)
Icahn School of Medicine at Mount Sinai NIH NIA
5R01AG061028-04

Leveraging the Framingham Study to Investigate Relationships between Traumatic Brain Injury, Military Service, Alzheimer's Disease and Related Dementias
09/01/2018 - 08/31/2022 (PI)
Department of Defense/Army Medical Research Acquisition Activity


Genetic Architecture of Memory and Executive Functioning in Alzheimer's Disease
09/01/2014 - 05/31/2019 (Co-Investigator)
University of Washington NIH NIA
5R01AG042437-04

Genetic and Neuropsychological Heterogeneity in Alzheimer's Disease
08/15/2014 - 05/31/2019 (PI)
NIH/National Institute on Aging
5K23AG046377-05

Exploring MAPT and tau-related genes in chonic traumatic encephalopathy
10/01/2015 - 09/30/2017 (PI)
Alzheimer's Association


Personnel agreement for research services of Jesse Mez
07/01/2014 - 06/30/2015 (Key Person)
PI: Andrew E. Budson, MD
VA Boston Healthcare System

1. Morrison MS, Aparicio HJ, Blennow K, Zetterberg H, Ashton NJ, Karikari TK, Tripodis Y, Martin B, Palmisano JN, Sugarman MA, Frank B, Steinberg EG, Turk KW, Budson AE, Au R, Goldstein LE, Jun GR, Kowall NW, Killiany R, Qiu WQ, Stern RA, Mez J, McKee AC, Stein TD, Alosco ML. Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy. Brain. 2022 Oct 21; 145(10):3546-3557.View Related Profiles.

   Budson, Andrew
   McKee, Ann
   Steinberg, Eric
   Jun, Gyungah
   Aparicio, Hugo
   Mez, Jesse
   Turk, Katherine
   Goldstein, Lee
   Alosco, Michael
   Kowall, Neil
   Au, Rhoda
   Stern, Robert
   Killiany, Ronald
   Stein, Thor
   Tripodis, Yorghos
   

   PMID: 35554506; DOI: 10.1093/brain/awac175;
2. Atherton K, Han X, Chung J, Cherry JD, Baucom Z, Saltiel N, Nair E, Abdolmohammadi B, Uretsky M, Khan MM, Shea C, Durape S, Martin BM, Palmisano JN, Farrell K, Nowinski CJ, Alvarez VE, Dwyer B, Daneshvar DH, Katz DI, Goldstein LE, Cantu RC, Kowall NW, Alosco ML, Huber BR, Tripodis Y, Crary JF, Farrer L, Stern RA, Stein TD, McKee AC, Mez J. Association of APOE Genotypes and Chronic Traumatic Encephalopathy. JAMA Neurol. 2022 Aug 01; 79(8):787-796.View Related Profiles.

   McKee, Ann
   Huber, Bertrand
   Dwyer, Brigid
   Nowinski, Christopher
   Daneshvar, Daniel
   Katz, Douglas
   Chung, Jaeyoon
   Mez, Jesse
   Cherry, Jonathan
   Goldstein, Lee
   Farrer, Lindsay
   Alosco, Michael
   Kowall, Neil
   Stern, Robert
   Stein, Thor
   Alvarez, Victor
   Tripodis, Yorghos
   

   PMID: 35759276; DOI: 10.1001/jamaneurol.2022.1634;
3. Eissman JM, Dumitrescu L, Mahoney ER, Smith AN, Mukherjee S, Lee ML, Scollard P, Choi SE, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski CC, Hernandez Saucedo H, Widaman KF, Buckley RF, Properzi MJ, Mormino EC, Yang HS, Harrison TM, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Zhong X, Raghavan NS, Vardarajan BN, Pericak-Vance MA, Farrer LA, Wang LS, Cruchaga C, Schellenberg GD, Cox NJ, Haines JL, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Cuccaro ML, Bennett DA, Schneider JA, Crane PK, Jefferson AL, Hohman TJ. Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease. Brain. 2022 Jul 29; 145(7):2541-2554.View Related Profiles.

   Mez, Jesse
   Gifford, Katherine
   Farrer, Lindsay
   

   PMID: 35552371; DOI: 10.1093/brain/awac177;
4. LeClair J, Weuve J, Fox MP, Mez J, Alosco ML, Nowinski C, McKee A, Tripodis Y. Relationship Between Level of American Football Playing and Diagnosis of Chronic Traumatic Encephalopathy in a Selection Bias Analysis. Am J Epidemiol. 2022 Jul 23; 191(8):1429-1443.View Related Profiles.

   McKee, Ann
   Nowinski, Christopher
   Weuve, Jennifer
   Mez, Jesse
   Fox, Matthew
   Alosco, Michael
   Tripodis, Yorghos
   

   PMID: 35434739; DOI: 10.1093/aje/kwac075;
5. Chung J, Das A, Sun X, Sobreira DR, Leung YY, Igartua C, Mozaffari S, Chou YF, Thiagalingam S, Mez J, Zhang X, Jun GR, Stein TD, Kunkle BW, Martin ER, Pericak-Vance MA, Mayeux R, Haines JL, Schellenberg GD, Nobrega MA, Lunetta KL, Pinto JM, Wang LS, Ober C, Farrer LA. Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women. Alzheimers Dement. 2022 Jun 30.View Related Profiles.

   Jun, Gyungah
   Chung, Jaeyoon
   Mez, Jesse
   Lunetta, Kathryn
   Farrer, Lindsay
   Thiagalingam, Sam
   Stein, Thor
   

   PMID: 35770850; DOI: 10.1002/alz.12719;
6. Qiu S, Miller MI, Joshi PS, Lee JC, Xue C, Ni Y, Wang Y, De Anda-Duran I, Hwang PH, Cramer JA, Dwyer BC, Hao H, Kaku MC, Kedar S, Lee PH, Mian AZ, Murman DL, O'Shea S, Paul AB, Saint-Hilaire MH, Alton Sartor E, Saxena AR, Shih LC, Small JE, Smith MJ, Swaminathan A, Takahashi CE, Taraschenko O, You H, Yuan J, Zhou Y, Zhu S, Alosco ML, Mez J, Stein TD, Poston KL, Au R, Kolachalama VB. Multimodal deep learning for Alzheimer's disease dementia assessment. Nat Commun. 2022 Jun 20; 13(1):3404.View Related Profiles.

   Mian, Asim
   Dwyer, Brigid
   Takahashi, Courtney
   Mez, Jesse
   Yuan, Jin
   Shih, Ludy
   Alosco, Michael
   Kaku, Michelle
   Au, Rhoda
   O'Shea, Sarah
   Zhu, Shuhan
   Stein, Thor
   Kolachalama, Vijaya
   

   PMID: 35725739; DOI: 10.1038/s41467-022-31037-5;
7. Alvia M, Aytan N, Spencer KR, Foster ZW, Rauf NA, Guilderson L, Robey I, Averill JG, Walker SE, Alvarez VE, Huber BR, Mathais R, Cormier KA, Nicks R, Pothast M, Labadorf A, Agus F, Alosco ML, Mez J, Kowall NW, McKee AC, Brady CB, Stein TD. MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis. Front Neurosci. 2022; 16:855096.View Related Profiles.

   Labadorf, Adam
   McKee, Ann
   Huber, Bertrand
   Brady, Christopher
   Mez, Jesse
   Alosco, Michael
   Kowall, Neil
   Aytan, Nurgul
   Stein, Thor
   Alvarez, Victor
   

   PMID: 35663558; DOI: 10.3389/fnins.2022.855096;
8. You Y, Hersh SW, Aslebagh R, Shaffer SA, Ikezu S, Mez J, Lunetta KL, Logue MW, Farrer LA, Ikezu T. Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Aging Cell. 2022 Jun; 21(6):e13617.View Related Profiles.

   Mez, Jesse
   Lunetta, Kathryn
   Farrer, Lindsay
   Logue, Mark
   Ikezu, Tsuneya
   You, Yang
   

   PMID: 35567427; DOI: 10.1111/acel.13617;
9. Frank B, Ally M, Tripodis Y, Puzo C, Labriolo C, Hurley L, Martin B, Palmisano J, Chan L, Steinberg E, Turk K, Budson A, O'Connor M, Au R, Qiu WQ, Goldstein L, Kukull W, Kowall N, Killiany R, Stern R, Stein T, McKee A, Mez J, Alosco M. Trajectories of Cognitive Decline in Brain Donors With Autopsy-Confirmed Alzheimer Disease and Cerebrovascular Disease. Neurology. 2022 Jun 14; 98(24):e2454-e2464.View Related Profiles.

   Budson, Andrew
   McKee, Ann
   Steinberg, Eric
   Mez, Jesse
   Turk, Katherine
   Goldstein, Lee
   O'Connor, Maureen
   Alosco, Michael
   Kowall, Neil
   Au, Rhoda
   Stern, Robert
   Killiany, Ronald
   Stein, Thor
   Tripodis, Yorghos
   

   PMID: 35444054; DOI: 10.1212/WNL.0000000000200304;
10. Yuan J, Au R, Karjadi C, Ang TF, Devine S, Auerbach S, DeCarli C, Libon DJ, Mez J, Lin H. Associations Between the Digital Clock Drawing Test and Brain Volume: Large Community-Based Prospective Cohort (Framingham Heart Study). J Med Internet Res. 2022 Apr 15; 24(4):e34513.View Related Profiles.

    Lin, Honghuang
    Mez, Jesse
    Au, Rhoda
    Auerbach, Sanford
    Ang, Ting Fang Alvin
    

    PMID: 35436225; DOI: 10.2196/34513;

Showing 10 of 105 results. Show More

Can Football Fans Watch with a Clear Conscience?

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New research suggests intensity of hits in sports, not years played, may be better predictor of devastating brain damage

Genetic Variation May Explain Differences in CTE Risk After Repetitive Head Impact

Genetic variant may increase risk for CTE severity among older individuals with repetitive head impacts

Boston University CTE study: Genes may play major role in CTE severity

Former football pros die at a faster rate than baseball veterans—and the reasons are surprising

More Years Playing Hockey, Higher Odds for CTE Linked to Head Injury

More Years of Ice Hockey Play Tied to Higher CTE Risk

Boston University scientists making progress in CTE research

BU scientists getting closer to diagnosing CTE in Living people using MRI

Boston University scientists getting closer to diagnosing CTE in living people using MRI

MRI Might Spot Concussion-Linked CTE in Living Patients

MRI Might Spot Concussion-Linked CTE in Living Patient

BU Researchers: CTE Study Offers Potential Path For Diagnosing The Brain Disease Before Death

Each Year You Play Football Increases Your Chances of Developing CTE by 30 Percent

Soccer Heading Has Greater Impact on Memory in ApoE4 Carriers

Soccer Headers Might Be More Risky for APOE4 Genotype Carriers

Pointed ‘Tackle Can Wait’ TV ad hits amid sobering new CTE study’s stats

Every 2.6 Years of Playing American Football Doubles Risk of Devastating Brain Disease

NFL Stars' Risk of Developing the Degenerative Brain Disease CTE Soars by a THIRD Every Year They Play, Study Finds

Scary: Study Finds Every Year of Tackle Football Raises Chances of CTE 30%

NFL stars’ risk of developing the degenerative brain disease CTE soars by a THIRD every year they play, study finds

CTE Risk Goes Up 30% For Each Year Of Playing Football

BU Research Finds Link Between Playing Football and CTE

CTE Risk in Football Players Doubles Every Five Years, New Study Finds

CTE Risk More Than Doubles after Just Three Years of Playing Football

CTE Risk, Severity Increases With Years Playing Football, Study Shows

College Football Season Is Here. Will Universities Continue To Ignore The Risk Of Brain Damage?

New Jersey Unveils New Limits on High School Football Practices

Cannabis Studied to Treat Conditions from Football-Related Brain Trauma

Why We Still Don’t Know How Many NFL Players Have CTE

What's the Risk of Chronic Traumatic Encephalopathy for NFL Players?

Some People May Have Increased CTE Risk Because Of Their Genes

Why Some People’s CTE Symptoms Are More Severe Than Others

Why do some people get CTE? It may be in their genes

Why Don't All Football Players Develop CTE? It May Be Genetics

MED Researchers: Youth Football Linked to Earlier Brain Problems