Jesse B. Mez, MD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology

MD, University of Maryland School of Medicine
MS, Columbia University School of Public Health
BS, Cornell University



Jesse Mez, MD, MS, is an Associate Professor of Neurology at Boston University (BU) Chobanian & Avedisian School of Medicine. A neurologist with clinical training in aging and dementia and research training in biostatistics/statistical genetics and epidemiology, he is the Associate Director of the BU Alzheimer’s Disease Research Center (ADRC), Co-Director of Clinical Research of the BU Chronic Traumatic Encephalopathy (CTE) Center and co-leads the Framingham Heart Study Brain Aging Program Clinical Core. He is also an AD Genetic Consortium and AD Sequencing Project Investigator. His research seeks to understand the genetic, neuropathological, epidemiological, and clinical aspects of AD, CTE, and related dementias. He is an internationally recognized expert on CTE, having been a lead or co-author on several of the most highly cited manuscripts and an invited lecturer in national and international venues on the topic. Ongoing research themes include 1) the relationship between traumatic brain injury, exposure to repetitive head impacts from contact sports and military service, and dementia-related outcomes and their interaction with genetic factors, 2) clinicopathologic correlation in CTE with the goal to accurately diagnose CTE in life, 3) genetic architecture, neuropathology and clinical course of AD subtypes, as defined by variation in neuropsychological presentation and 4) interaction between genetic and environmental factors and risk for and resilience from AD. He is a Principal Investigator or Core/Project Leader, on six NIH and DOD-funded grants and is an author of more than 150 research articles, reviews, editorials, and book chapters. He also cares for patients with AD and related dementias, including those at risk for CTE in the BU/Boston Medical Center Memory and Aging Clinic.

He received his AB from Cornell University in Mathematics, his MD from the University of Maryland School of Medicine, and his MS in Biostatistics with an emphasis on Statistical Genetics from the Columbia University Mailman School of Public Health. He completed his Neurology Residency at the Harvard Mass General Brigham Program in Boston. This was followed by a Clinical Fellowship in Aging and Dementia and a Research Fellowship in Neuroepidemiology at Columbia University College of Physicians and Surgeons.

Investigator
Framingham Heart Study


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Validation of Lens Beta-Amyloid as a Novel Biomarker for Early Detection of Alzheimer's Disease at the Boston University Alzheimer's Disease Research
09/30/2023 - 06/30/2028 (Multi-PI)
PI: Jesse B. Mez, MD
NIH/National Institute on Aging
5R01AG077588-02

Boston University Alzheimer's Disease Research Center
08/15/2021 - 06/30/2026 (Key Person)
PI: Ann C. McKee, MD
NIH/National Institute on Aging
5P30AG072978-04

Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium
09/30/2021 - 08/31/2025 (Subcontract PI)
Vanderbilt University Medical Center NIH NIA
5U24AG074855-04

Protocol number BAN2401-G000-303: AHEAD 3-45 Study: A Placebo-Controlled, Double-Blind, Parallel-Treatment Arm, 216 Week Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Subject
01/01/2020 - 12/31/2024 (PI of Sub-Project / SP)
University of Southern California Eisai, Inc


Leveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD)
03/15/2019 - 11/30/2024 (Multi-PI)
PI: Jesse B. Mez, MD
Icahn School of Medicine at Mount Sinai NIH NIA
5R01AG061028-05S1

AHEAD Plasma Extension (APEX)
05/01/2023 - 04/30/2024 (Subcontract PI)
University of Southern California NIH NIA
5R01AG053798-05

Leveraging the Framingham Study to Investigate Relationships between Traumatic Brain Injury, Military Service, Alzheimer's Disease and Related Dementias
09/01/2018 - 08/31/2023 (PI)
Department of Defense/Army Medical Research Acquisition Activity


ADNI Psychometrics
12/01/2017 - 03/31/2023 (Subcontract PI)
University of Washington NIH NIA
5R01AG029672-10

Genetic Architecture of Memory and Executive Functioning in Alzheimer's Disease
09/01/2014 - 05/31/2019 (Co-Investigator)
University of Washington NIH NIA
5R01AG042437-04

Genetic and Neuropsychological Heterogeneity in Alzheimer's Disease
08/15/2014 - 05/31/2019 (PI)
NIH/National Institute on Aging
5K23AG046377-05

Showing 10 of 12 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2024 Validation of Lens Beta-Amyloid as a Novel Biomarker for Early Detection of Alzheimer's Disease at the Boston University Alzheimer's Disease Research 5R01AG077588-02
2024 Core B: Clinical Core 5P30AG072978-04-9742
2023 Validation of Lens Beta-Amyloid as a Novel Biomarker for Early Detection of Alzheimer's Disease at the Boston University Alzheimer's Disease Research 1R01AG077588-01A1
2023 Core B: Clinical Core 5P30AG072978-03-9742
2023 Clinicopathological Correlation in Chronic Traumatic Encephalopathy (CTE) and Chronic Traumatic Brain Injury (cTBI) 5U54NS115266-05-6543
2023 Leveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD) 5R01AG061028-05
2023 Leveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD) 3R01AG061028-05S1
2022 Core B: Clinical Core 5P30AG072978-02-9742
2022 Clinicopathological Correlation in Chronic Traumatic Encephalopathy (CTE) and Chronic Traumatic Brain Injury (cTBI) 5U54NS115266-04-6601
2022 Leveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD) 5R01AG061028-04
Showing 10 of 23 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Alosco ML, Mejía Pérez J, Culhane JE, Shankar R, Nowinski CJ, Bureau S, Mundada N, Smith K, Amuiri A, Asken B, Groh JR, Miner A, Pettway E, Mosaheb S, Tripodis Y, Windon C, Mercier G, Stern RA, Grinberg LT, Soleimani-Meigooni DN, Christian BT, Betthauser TJ, Stein TD, McKee AC, Mathis CA, Abrahamson EE, Ikonomovic MD, Johnson SC, Mez J, La Joie R, Schonhaut D, Rabinovici GD. 18F-MK-6240 tau PET in patients at-risk for chronic traumatic encephalopathy. Mol Neurodegener. 2025 Feb 25; 20(1):23.View Related Profiles. PMID: 39994806; PMCID: PMC11852567; DOI: 10.1186/s13024-025-00808-1;
     
  2. Kang M, Ang TFA, Devine SA, Sherva R, Mukherjee S, Trittschuh EH, Gibbons LE, Scollard P, Lee M, Choi SE, Klinedinst B, Nakano C, Dumitrescu LC, Hohman TJ, Cuccaro ML, Saykin AJ, Kukull WA, Bennett DA, Wang LS, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Crane PK, Au R, Lunetta KL, Mez J, Farrer LA. Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures. medRxiv. 2025 Feb 13.View Related Profiles. PMID: 39990565; PMCID: PMC11844603; DOI: 10.1101/2025.02.11.25322014;
     
  3. Altaras C, Ly MT, Schultz O, Barr WB, Banks SJ, Wethe JV, Tripodis Y, Adler CH, Balcer LJ, Bernick C, Zetterberg H, Blennow K, Ashton N, Peskind E, Cantu RC, Coleman MJ, Lin AP, Koerte IK, Bouix S, Daneshvar D, Dodick DW, Geda YE, Katz DL, Weller JL, Mez J, Palmisano JN, Martin B, Cummings JL, Reiman EM, Shenton ME, Stern RA, Alosco ML. Dispersion-based cognitive intra-individual variability in former American football players: Association with traumatic encephalopathy syndrome, repetitive head impacts, and biomarkers. Clin Neuropsychol. 2025 Jan 26; 1-29.View Related Profiles. PMID: 39865747
     
  4. Ly MT, Altaras C, Tripodis Y, Adler CH, Balcer LJ, Bernick C, Zetterberg H, Blennow K, Peskind ER, Banks SJ, Barr WB, Wethe JV, Lenio S, Bondi MW, Delano-Wood LM, Cantu RC, Coleman MJ, Dodick DW, Mez J, Daneshvar DH, Palmisano JN, Martin B, Lin AP, Koerte IK, Bouix S, Cummings JL, Reiman EM, Shenton ME, Stern RA, Alosco ML. Single- versus two-test criteria for cognitive impairment: associations with CSF and imaging markers in former American football players. Clin Neuropsychol. 2025 Jan 20; 1-25.View Related Profiles. PMID: 39834028
     
  5. Durant A, Mukherjee S, Lee ML, Choi SE, Scollard P, Klinedinst BS, Trittschuh EH, Mez J, Farrer LA, Gifford KA, Cruchaga C, Hassenstab J, Naj AC, Wang LS, Johnson SC, Engelman CD, Kukull WA, Keene CD, Saykin AJ, Cuccaro ML, Kunkle BW, Pericak-Vance MA, Martin ER, Bennett DA, Barnes LL, Schneider JA, Bush WS, Haines JL, Mayeux R, Vardarajan BN, Albert MS, Thompson PM, Jefferson AL, Crane PK, Dumitrescu L, Archer DB, Hohman TJ, Gaynor LS. Evaluating the association of APOE genotype and cognitive resilience in SuperAgers. medRxiv. 2025 Jan 07.View Related Profiles. PMID: 39830268; PMCID: PMC11741496; DOI: 10.1101/2025.01.07.25320117;
     
  6. Kang K, Zhang P, Dumitrescu L, Mukherjee S, Lee ML, Choi SE, Trittschuh EH, Mez J, Saykin AJ, Gifford KA, Buckley RF, Gao X, Di J, Crane PK, Hohman TJ, Liu D. The Dynamics of Cognitive Decline towards Alzheimer's Disease Progression: Results from ADSP-PHC's Harmonized Cognitive Composites. medRxiv. 2025 Jan 06.View Related Profiles. PMID: 39830238; PMCID: PMC11741457; DOI: 10.1101/2025.01.01.25319850;
     
  7. Richardson TE, Orr ME, Orr TC, Rohde SK, Ehrenberg AJ, Thorn EL, Christie TD, Flores-Almazan V, Afzal R, De Sanctis C, Maldonado-Díaz C, Hiya S, Canbeldek L, Kulumani Mahadevan LS, Slocum C, Samanamud J, Clare K, Scibetta N, Yokoda RT, Koenigsberg D, Marx GA, Kauffman J, Goldstein A, Selmanovic E, Drummond E, Wisniewski T, White CL, Goate AM, Crary JF, Farrell K, Alosco ML, Mez J, McKee AC, Stein TD, Bieniek KF, Kautz TF, Daoud EV, Walker JM. Spatial proteomic differences in chronic traumatic encephalopathy, Alzheimer's disease, and primary age-related tauopathy hippocampi. Alzheimers Dement. 2025 Feb; 21(2):e14487.View Related Profiles. PMID: 39737785; PMCID: PMC11848160; DOI: 10.1002/alz.14487;
     
  8. Nicks R, Shah A, Stathas SA, Kirsch D, Horowitz SM, Saltiel N, Calderazzo SM, Butler MLMD, Cormier KA, Aytan N, Tu-Zahra F, Mathias R, Faheem F, Marcus S, Spurlock E, Fishbein L, Esnault CD, Boden A, Rosen G, Xia W, Daley S, Meng G, Martin BR, Daneshvar DH, Nowinski CJ, Alosco ML, Mez J, Tripodis Y, Huber BR, Alvarez VE, Cherry JD, McKee AC, Stein TD. Neurodegeneration in the cortical sulcus is a feature of chronic traumatic encephalopathy and associated with repetitive head impacts. Acta Neuropathol. 2024 Dec 06; 148(1):79.View Related Profiles. PMID: 39643767; PMCID: PMC11624223; DOI: 10.1007/s00401-024-02833-8;
     
  9. Abdolmohammadi B, Tuz-Zahra F, Uretsky M, Nicks R, Mosaheb S, Labonte J, Yhang E, Durape S, Martin B, Palmisano J, Nowinski C, Cherry JD, Alvarez VE, Huber BR, Dams-O'Connor K, Crary J, Dwyer B, Daneshvar DH, Goldstein LE, Au R, Katz DI, Kowall NW, Cantu RC, Stern RA, Alosco ML, Stein TD, Tripodis Y, McKee AC, Mez J. Duration of Ice Hockey Play and Chronic Traumatic Encephalopathy. JAMA Netw Open. 2024 Dec 02; 7(12):e2449106.View Related Profiles. PMID: 39630446; PMCID: PMC11618473; DOI: 10.1001/jamanetworkopen.2024.49106;
     
  10. Uretsky M, Nair E, Burton R, Cronin SW, Rousseau D, Tuz-Zahra F, Durape S, Abdolmohammadi B, Baucom Z, Saltiel N, Shah A, Martin B, Palmisano J, Cherry JD, Daneshvar D, Dwyer B, Dams-O'Connor K, Crary J, Goldstein L, Huber B, Katz D, Kowall N, Cantu RC, Alvarez VE, Stern RA, Stein TD, Tripodis Y, McKee AC, Alosco ML, Mez J. Chronic Traumatic Encephalopathy, Family History of Mental Illness, and Aggression in Brain Donors With Repetitive Head Impact Exposure. Neurology. 2024 Dec 24; 103(12):e210056.View Related Profiles. PMID: 39602665; PMCID: PMC11604107; DOI: 10.1212/WNL.0000000000210056;
     
Showing 10 of 180 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 180 publications over 17 distinct years, with a maximum of 37 publications in 2023

YearPublications
20041
20071
20091
20101
20135
20141
20155
20168
20179
20187
201911
202018
202120
202225
202337
202424
20256


CTE Plus Family History of Mental Illness Raises Odds for Aggression

US News and World Report 12/2/2024

10 Things BU CTE Center Research Has Taught Us About the Brain Dangers of Contact Sports and Military Service

The Brink 10/11/2024

How severe was Aaron Hernandez's CTE? A new show looks at his life and violent behavior

Today.com 9/16/2024

Diagnosing CTE before death: families play a crucial role in advancing the science

CBS News 9/12/2024

New Boston University study could help diagnose CTE before death

NBC 10 Boston 2/7/2024

BU researchers publish ‘crucial’ study that could help diagnose CTE before death

Boston.com 2/6/2024

BU researchers say they’re closer to diagnosing CTE during life, rather than after death

Boston 25 2/6/2024

Boston University researchers may be closer to identifying CTE in living patients

CBS News 2/6/2024

New Boston University study may help develop way to diagnose CTE in living patients

WCVB-TV 2/6/2024

Researchers get closer to diagnosing CTE in living patients

Futurity 2/6/2024

Researchers Are One Step Closer to Diagnosing CTE during Life, Rather Than after Death

BU Today 2/5/2024

New Research Suggests That Cumulative Force Of Head Blows, Not The Frequency Of Hits, Is A Better Predictor Of CTE

Chip Chick 8/11/2023

Force of hits, not just number, raises CTE risk

Futurity 6/26/2023

Which Football Players Face Highest Odds for Brain Disorder CTE? New Findings May Tell

US News & World Report 6/26/2023

Head Hits, Not Concussions, Tied to CTE

MedPage Today 6/21/2023

The Force of Blows to the Head, Not Just How Many, Raises Likelihood of CTE

BU Today 6/21/2023

For NHL Players, More Fighting on the Ice Is Linked to Shorter Lives

Health Day 5/11/2023

NHL commissioner disputes link between hockey and CTE brain disease

NPR 4/19/2023

Can Football Fans Watch with a Clear Conscience?

Psychology Today 1/6/2023

New research suggests intensity of hits in sports, not years played, may be better predictor of devastating brain damage

Boston Globe 8/3/2022

Genetic Variation May Explain Differences in CTE Risk After Repetitive Head Impact

Medscape 7/11/2022

Genetic variant may increase risk for CTE severity among older individuals with repetitive head impacts

Medical Xpress 6/27/2022

Boston University CTE study: Genes may play major role in CTE severity

Boston Herald 6/27/2022

Former football pros die at a faster rate than baseball veterans—and the reasons are surprising

Science 6/24/2022

More Years Playing Hockey, Higher Odds for CTE Linked to Head Injury

Health Day 3/3/2022

More Years of Ice Hockey Play Tied to Higher CTE Risk

Medscape 3/3/2022

Boston University scientists making progress in CTE research

WHDH-TV 12/13/2021

Boston University scientists getting closer to diagnosing CTE in living people using MRI

Boston Herald 12/11/2021

MRI Might Spot Concussion-Linked CTE in Living Patient

Health Day 12/8/2021

MRI Might Spot Concussion-Linked CTE in Living Patients

US News & World Report 12/8/2021

BU Researchers: CTE Study Offers Potential Path For Diagnosing The Brain Disease Before Death

WBUR 4/7/2021

Each Year You Play Football Increases Your Chances of Developing CTE by 30 Percent

League of Fans 10/29/2020

Soccer Heading Has Greater Impact on Memory in ApoE4 Carriers

Alzforum 1/31/2020

Soccer Headers Might Be More Risky for APOE4 Genotype Carriers

Medscape 1/30/2020

Pointed ‘Tackle Can Wait’ TV ad hits amid sobering new CTE study’s stats

Sporting News 10/14/2019

Every 2.6 Years of Playing American Football Doubles Risk of Devastating Brain Disease

ZME Science 10/9/2019

Scary: Study Finds Every Year of Tackle Football Raises Chances of CTE 30%

The Daily Wire 10/8/2019

NFL stars’ risk of developing the degenerative brain disease CTE soars by a THIRD every year they play, study finds

Daily Mail 10/8/2019

CTE Risk Goes Up 30% For Each Year Of Playing Football

Futurity 10/8/2019

BU Research Finds Link Between Playing Football and CTE

WHDH 10/8/2019

CTE Risk in Football Players Doubles Every Five Years, New Study Finds

Boston Magazine 10/7/2019

CTE Risk More Than Doubles after Just Three Years of Playing Football

BU Today 10/7/2019

CTE Risk, Severity Increases With Years Playing Football, Study Shows

Boston Herald 10/7/2019

College Football Season Is Here. Will Universities Continue To Ignore The Risk Of Brain Damage?

Forbes 9/2/2019

New Jersey Unveils New Limits on High School Football Practices

The New York Times 2/13/2019

Cannabis Studied to Treat Conditions from Football-Related Brain Trauma

WeedMaps 2/4/2019

Why We Still Don’t Know How Many NFL Players Have CTE

Five Thirty Eight 12/17/2018

What's the Risk of Chronic Traumatic Encephalopathy for NFL Players?

Inside Science 11/29/2018

Some People May Have Increased CTE Risk Because Of Their Genes

Inquisitr 11/4/2018

Why Some People’s CTE Symptoms Are More Severe Than Others

BU Today 11/3/2018

Why do some people get CTE? It may be in their genes

CNN Todau 11/3/2018

Why Don't All Football Players Develop CTE? It May Be Genetics

WBGH 11/3/2018

MED Researchers: Youth Football Linked to Earlier Brain Problems

BU Today 4/30/2018

2015 Alzheimer’s Association New Investigator Award
2014 Junior Faculty Spivack Neuroscience Scholar
2013 BU ADC Pilot Grant
2011 NIH Clinical Research Loan Repayment Program recipient
2002 National Student Research Forum grant
2002 Maryland House of Delegates Graduate Scholarship recipient
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