Jesse B. Mez, MD
Assistant Professor
Boston University School of Medicine
Dept of Neurology

MD, University of Maryland School of Medicine
MS, Columbia University School of Public Health




Dr. Mez completed his undergraduate studies at Cornell University and earned his medical degree from the University of Maryland School of Medicine. He completed residency training in Neurology at Massachusetts General and Brigham and Women’s Hospitals. He completed a clinical fellowship in Aging and Dementia and a research fellowship in Neuroepidemiology at Columbia University. During fellowship training, he also earned a Masters in Biostatistics with a focus on Statistical Genetics from the Mailman School of Public Health at Columbia. In 2013, he became an Assistant Professor of Neurology at Boston University (BU) School of Medicine. In 2014, he became Associate Director of the BU Alzheimer's Disease Center (ADC) Clinical Core.

Research Interests
Dr. Mez’s research seeks to understand genetic, neuropathological, epidemiological and clinical aspects of various forms of dementia. He is the recipient of a K-23 Mentored Patient Oriented Career Development Award that investigates the role of genetic and non-genetic factors in atypical clinical presentations of Alzheimer’s disease. Since 2014, he led the clinical arm of the Understanding Neurologic Injury and Traumatic Encephalopathy (UNITE) study, a U01 project examining the neuropathology and clinical symptoms of brain donors who have experienced repetitive head impacts, including investigating clinicopathological correlation in chronic traumatic encephalopathy (CTE). He also is interested in how the interaction of genetic risk factors and trauma influence dementia risk, particularly chronic traumatic encephalopathy. He also is a Framingham Heart Study (FHS) investigator, leads FHS traumatic brain injury (TBI)-related projects and is involved with reaching consensus dementia diagnoses for FHS participants.

Awards and Memberships
Dr. Mez is a 2015 Spivack Neuroscience Scholar and a recipient of the 2018 Carlos S. Kase Outstanding Contribution to Neurology Research Award. He is a recipient of a Peer Reviewed Alzheimer's Research Project Grant from the Department of Defense, a K23 Mentored Patient-Oriented Research Career Development Award from the National Institute on Aging, a New Investigator Research Grant from the Alzheimer's Association, a BU ADC Pilot Grant, a BU Clinical and Translational Science Institute Pilot Grant and the NIH Loan Repayment Program. He is a member of the American Academy of Neurology, the American Society of Human Genetics, the International Society to Advance Alzheimer’s Research and Treatment and the Society for Behavioral and Cognitive Neurology


ADNI Psychometrics
12/01/2017 - 03/31/2022 (PI)
University of Washington NIH NIA
5R01AG029672-07

Leveraging the Framingham Study to Investigate Relationships between Traumatic Brain Injury, Military Service, Alzheimer's Disease and Related Dementias
09/01/2018 - 08/31/2021 (PI)
Department of Defense/Army Medical Research Acquisition Activity


Genetic Architecture of Memory and Executive Functioning in Alzheimer's Disease
09/01/2014 - 05/31/2019 (Co-PI)
PI: Richard Sherva, PhD
University of Washington NIH NIA
5R01AG042437-04

Genetic and Neuropsychological Heterogeneity in Alzheimer's Disease
08/15/2014 - 05/31/2019 (PI)
NIH/National Institute on Aging
5K23AG046377-05

Exploring MAPT and tau-related genes in chonic traumatic encephalopathy
10/01/2015 - 09/30/2017 (PI)
Alzheimer's Association




Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Standring OJ, Friedberg J, Tripodis Y, Chua AS, Cherry JD, Alvarez VE, Huber BR, Xia W, Mez J, Alosco ML, Nicks R, Mahar I, Pothast MJ, Gardner HM, Meng G, Palmisano JN, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, McKee AC, Stein TD. Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy. Acta Neuropathol. 2019 Jun 10.View Related Profiles. PMID: 31183671.
     
  2. DeVivo R, Zajac L, Mian A, Cervantes-Arslanian A, Steinberg E, Alosco ML, Mez J, Stern R, Killany R. Differentiating Between Healthy Control Participants and Those with Mild Cognitive Impairment Using Volumetric MRI Data. J Int Neuropsychol Soc. 2019 May 27; 1-11.View Related Profiles. PMID: 31130145.
     
  3. Glymour MM, Gibbons LE, Gilsanz P, Gross AL, Mez J, Brewster PW, Marden J, Zahodne LB, Nho K, Hamilton J, Li G, Larson EB, Crane PK. Initiation of antidepressant medication and risk of incident stroke: using the Adult Changes in Thought cohort to address time-varying confounding. Ann Epidemiol. 2019 May 11. PMID: 31200987.
     
  4. Sugarman MA, McKee AC, Stein TD, Tripodis Y, Besser LM, Martin B, Palmisano JN, Steinberg EG, O'Connor MK, Au R, McClean M, Killiany R, Mez J, Weiner MW, Kowall NW, Stern RA, Alosco ML. Failure to detect an association between self-reported traumatic brain injury and Alzheimer's disease neuropathology and dementia. Alzheimers Dement. 2019 May; 15(5):686-698.View Related Profiles. PMID: 30852157; DOI: 10.1016/j.jalz.2018.12.015;.
     
  5. Patel D, Mez J, Vardarajan BN, Staley L, Chung J, Zhang X, Farrell JJ, Rynkiewicz MJ, Cannon-Albright LA, Teerlink CC, Stevens J, Corcoran C, Gonzalez Murcia JD, Lopez OL, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg G, Kauwe JSK, Lunetta KL, Farrer LA. Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry. JAMA Netw Open. 2019 Mar 01; 2(3):e191350.View Related Profiles. PMID: 30924900.
     
  6. Mukherjee S, Mez J, Trittschuh EH, Saykin AJ, Gibbons LE, Fardo DW, Wessels M, Bauman J, Moore M, Choi SE, Gross AL, Rich J, Louden DKN, Sanders RE, Grabowski TJ, Bird TD, McCurry SM, Snitz BE, Kamboh MI, Lopez OL, De Jager PL, Bennett DA, Keene CD, Larson EB, Crane PK. Correction: Genetic data and cognitively defined late-onset Alzheimer's disease subgroups. Mol Psychiatry. 2019 Jan 15. PMID: 30647434.
     
  7. Mukherjee S, Mez J, Trittschuh EH, Saykin AJ, Gibbons LE, Fardo DW, Wessels M, Bauman J, Moore M, Choi SE, Gross AL, Rich J, Louden DKN, Sanders RE, Grabowski TJ, Bird TD, McCurry SM, Snitz BE, Kamboh MI, Lopez OL, De Jager PL, Bennett DA, Keene CD, Larson EB, Crane PK. Genetic data and cognitively defined late-onset Alzheimer's disease subgroups. Mol Psychiatry. 2018 Dec 04. PMID: 30514930.
     
  8. Cherry JD, Mez J, Crary JF, Tripodis Y, Alvarez VE, Mahar I, Huber BR, Alosco ML, Nicks R, Abdolmohammadi B, Kiernan PT, Evers L, Svirsky S, Babcock K, Gardner HM, Meng G, Nowinski CJ, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Farrer LA, McKee AC, Stein TD. Variation in TMEM106B in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2018 11 04; 6(1):115.View Related Profiles. PMID: 30390709.
     
  9. Adams JW, Alvarez VE, Mez J, Huber BR, Tripodis Y, Xia W, Meng G, Kubilus CA, Cormier K, Kiernan PT, Daneshvar DH, Chua AS, Svirsky S, Nicks R, Abdolmohammadi B, Evers L, Solomon TM, Cherry JD, Aytan N, Mahar I, Devine S, Auerbach S, Alosco ML, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, Au R, McKee AC, Stein TD. Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports. J Neuropathol Exp Neurol. 2018 Sep 01; 77(9):757-768.View Related Profiles. PMID: 30053297.
     
  10. Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Stern RA. Cerebrospinal fluid tau, Aß, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement. 2018 Sep; 14(9):1159-1170.View Related Profiles. PMID: 30049650.
     
Showing 10 of 45 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 45 publications over 11 distinct years, with a maximum of 9 publications in 2017

YearPublications
20041
20071
20091
20101
20135
20141
20155
20168
20179
20187
20196
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