Boston University Alzheimer's Disease Research Center
08/15/2021 - 06/30/2026 (Key Person)
PI: Ann C. McKee, MD
NIH/National Institute on Aging
5P30AG072978-03

The A45 Study: Combination anti-amyloid therapy for preclinical Alzheimer's disease
09/30/2019 - 05/31/2024 (Subcontract PI)
University of Southern California NIH NIA
1R01AG061848-01

AHEAD Plasma Extension (APEX)
05/01/2023 - 04/30/2024 (Subcontract PI)
University of Southern California NIH NIA
5R01AG053798-05

Protocol number BAN2401-G000-303: AHEAD 3-45 Study: A Placebo-Controlled, Double-Blind, Parallel-Treatment Arm, 216 Week Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Subject
01/01/2020 - 12/31/2023 (Subcontract PI)
University of Southern California Eisai, Inc


Leveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD)
03/15/2019 - 11/30/2023 (PI)
Icahn School of Medicine at Mount Sinai NIH NIA
5R01AG061028-05

Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium
09/30/2021 - 08/31/2023 (Subcontract PI)
Vanderbilt University Medical Center NIH NIA
5U24AG074855-02

Leveraging the Framingham Study to Investigate Relationships between Traumatic Brain Injury, Military Service, Alzheimer's Disease and Related Dementias
09/01/2018 - 08/31/2023 (PI)
Department of Defense/Army Medical Research Acquisition Activity


The A3 Study: Ante-Amyloid prevention of Alzheimer's disease
06/01/2019 - 04/30/2023 (Subcontract PI)
University of Southern California NIH NIA
5R01AG061848-03

ADNI Psychometrics
12/01/2017 - 03/31/2023 (Subcontract PI)
University of Washington NIH NIA
5R01AG029672-10

Genetic Architecture of Memory and Executive Functioning in Alzheimer's Disease
09/01/2014 - 05/31/2019 (Co-Investigator)
University of Washington NIH NIA
5R01AG042437-04

Showing 10 of 13 results. Show All Results

1. Walters S, Contreras AG, Eissman JM, Mukherjee S, Lee ML, Choi SE, Scollard P, Trittschuh EH, Mez JB, Bush WS, Kunkle BW, Naj AC, Peterson A, Gifford KA, Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang LS, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Hohman TJ, Dumitrescu L. Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults. JAMA Neurol. 2023 Sep 01; 80(9):929-939.View Related Profiles.

   Mez, Jesse
   Gifford, Katherine
   Farrer, Lindsay
   

   PMID: 37459083; PMCID: PMC10352930; DOI: 10.1001/jamaneurol.2023.2169;
2. Rosen G, Kirsch D, Horowitz S, Cherry JD, Nicks R, Kelley H, Uretsky M, Dell'Aquila K, Mathias R, Cormier KA, Kubilus CA, Mez J, Tripodis Y, Stein TD, Alvarez VE, Alosco ML, McKee AC, Huber BR. Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2023 Jul 25; 11(1):123.View Related Profiles.

   McKee, Ann
   Huber, Bertrand
   Mez, Jesse
   Cherry, Jonathan
   Alosco, Michael
   Stein, Thor
   Alvarez, Victor
   Tripodis, Yorghos
   

   PMID: 37491342; PMCID: PMC10369801; DOI: 10.1186/s40478-023-01612-y;
3. Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, Lucio da Fonseca E, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Iqbal T, Pathak O, Valladares O, Kuzma AB, Abner E, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ERR, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, Wingo TS, Wisniewski T, Woltjer RL, Woon M, Wright CB, Wu CK, Younkin SG, Yu CE, Yu L, Zhu X, Kunkle BW, Bush WS, Wang LS, Farrer LA, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Jun GR, Reitz C, Naj AC. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. medRxiv. 2023 Jul 08.View Related Profiles.

   McKee, Ann
   Jun, Gyungah
   Mez, Jesse
   Lunetta, Kathryn
   Farrer, Lindsay
   Logue, Mark
   Kowall, Neil
   Sherva, Richard
   Stern, Robert
   

   PMID: 37461624; PMCID: PMC10350126; DOI: 10.1101/2023.07.06.23292311;
4. Kang M, Ang TFA, Devine SA, Sherva R, Mukherjee S, Trittschuh EH, Gibbons LE, Scollard P, Lee M, Choi SE, Klinedinst B, Nakano C, Dumitrescu LC, Durant A, Hohman TJ, Cuccaro ML, Saykin AJ, Kukull WA, Bennett DA, Wang LS, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Crane PK, Au R, Lunetta KL, Mez JB, Farrer LA. A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores. Mol Neurodegener. 2023 Jun 22; 18(1):40.View Related Profiles.

   Mez, Jesse
   Lunetta, Kathryn
   Farrer, Lindsay
   Au, Rhoda
   Sherva, Richard
   Devine, Sherral
   Ang, Ting Fang Alvin
   

   PMID: 37349795; PMCID: PMC10286470; DOI: 10.1186/s13024-023-00633-4;
5. Daneshvar DH, Nair ES, Baucom ZH, Rasch A, Abdolmohammadi B, Uretsky M, Saltiel N, Shah A, Jarnagin J, Baugh CM, Martin BM, Palmisano JN, Cherry JD, Alvarez VE, Huber BR, Weuve J, Nowinski CJ, Cantu RC, Zafonte RD, Dwyer B, Crary JF, Goldstein LE, Kowall NW, Katz DI, Stern RA, Tripodis Y, Stein TD, McClean MD, Alosco ML, McKee AC, Mez J. Leveraging football accelerometer data to quantify associations between repetitive head impacts and chronic traumatic encephalopathy in males. Nat Commun. 2023 Jun 20; 14(1):3470.View Related Profiles.

   McKee, Ann
   Huber, Bertrand
   Dwyer, Brigid
   Nowinski, Christopher
   Daneshvar, Daniel
   Katz, Douglas
   Weuve, Jennifer
   Mez, Jesse
   Cherry, Jonathan
   Goldstein, Lee
   Alosco, Michael
   McClean, Michael
   Kowall, Neil
   Stern, Robert
   Stein, Thor
   Alvarez, Victor
   Tripodis, Yorghos
   

   PMID: 37340004; PMCID: PMC10281995; DOI: 10.1038/s41467-023-39183-0;
6. Li D, Farrell JJ, Mez J, Martin ER, Bush WS, Ruiz A, Boada M, de Rojas I, Mayeux R, Haines JL, Vance MAP, Wang LS, Schellenberg GD, Lunetta KL, Farrer LA. Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews. Alzheimers Dement. 2023 Jun 01.View Related Profiles.

   Mez, Jesse
   Lunetta, Kathryn
   Farrer, Lindsay
   

   PMID: 37260021
7. Chung J, Sahelijo N, Maruyama T, Hu J, Panitch R, Xia W, Mez J, Stein TD, Saykin AJ, Takeyama H, Farrer LA, Crane PK, Nho K, Jun GR. Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles. Alzheimers Dement. 2023 May 11.View Related Profiles.

   Jun, Gyungah
   Mez, Jesse
   Farrer, Lindsay
   Stein, Thor
   

   PMID: 37166019
8. Crane PK, Choi SE, Lee M, Scollard P, Sanders RE, Klinedinst B, Nakano C, Trittschuh EH, Mez J, Saykin AJ, Gibbons LE, Wang C, Mungas D, Zhu R, Foldi NS, Lamar M, Jutten R, Sikkes SAM, Grandoit E, Rabin LA, Jones RN, Tommet D, Mukherjee S. Measurement precision across cognitive domains in the Alzheimer's Disease Neuroimaging Initiative (ADNI) data set. Neuropsychology. 2023 May; 37(4):373-382. PMID: 37276134; PMCID: PMC10247161; DOI: 10.1037/neu0000901;
9. Scollard P, Choi SE, Lee ML, Mukherjee S, Trittschuh EH, Sanders RE, Gibbons LE, Joshi P, Devine S, Au R, Dams-O'Connor K, Saykin AJ, Seshadri S, Beiser A, Aparicio HJ, Salinas J, Gonzales MM, Pase MP, Ghosh S, Finney R, Mez J, Crane PK. Ceiling effects and differential measurement precision across calibrated cognitive scores in the Framingham Study. Neuropsychology. 2023 May; 37(4):383-397.View Related Profiles.

   Beiser, Alexa
   Aparicio, Hugo
   Mez, Jesse
   Au, Rhoda
   Seshadri, Sudha
   

   PMID: 37276135; PMCID: PMC10247160; DOI: 10.1037/neu0000828;
10. Fang Y, Doyle MF, Chen J, Mez J, Satizabal CL, Alosco ML, Qiu WQ, Lunetta KL, Murabito JM. Circulating immune cell phenotypes are associated with age, sex, CMV, and smoking status in the Framingham Heart Study offspring participants. Aging (Albany NY). 2023 Apr 27; 15(10):3939-3966.View Related Profiles.

    Satizabal, Claudia
    Mez, Jesse
    Murabito, Joanne
    Lunetta, Kathryn
    Alosco, Michael
    Fang, Yuan
    

    PMID: 37116193; PMCID: PMC10258017; DOI: 10.18632/aging.204686;

Showing 10 of 131 results. Show More

New Research Suggests That Cumulative Force Of Head Blows, Not The Frequency Of Hits, Is A Better Predictor Of CTE

---

Force of hits, not just number, raises CTE risk

Which Football Players Face Highest Odds for Brain Disorder CTE? New Findings May Tell

Head Hits, Not Concussions, Tied to CTE

The Force of Blows to the Head, Not Just How Many, Raises Likelihood of CTE

For NHL Players, More Fighting on the Ice Is Linked to Shorter Lives

NHL commissioner disputes link between hockey and CTE brain disease

Can Football Fans Watch with a Clear Conscience?

New research suggests intensity of hits in sports, not years played, may be better predictor of devastating brain damage

Genetic Variation May Explain Differences in CTE Risk After Repetitive Head Impact

Genetic variant may increase risk for CTE severity among older individuals with repetitive head impacts

Boston University CTE study: Genes may play major role in CTE severity

Former football pros die at a faster rate than baseball veterans—and the reasons are surprising

More Years Playing Hockey, Higher Odds for CTE Linked to Head Injury

More Years of Ice Hockey Play Tied to Higher CTE Risk

Boston University scientists making progress in CTE research

BU scientists getting closer to diagnosing CTE in Living people using MRI

Boston University scientists getting closer to diagnosing CTE in living people using MRI

MRI Might Spot Concussion-Linked CTE in Living Patients

MRI Might Spot Concussion-Linked CTE in Living Patient

BU Researchers: CTE Study Offers Potential Path For Diagnosing The Brain Disease Before Death

Each Year You Play Football Increases Your Chances of Developing CTE by 30 Percent

Soccer Heading Has Greater Impact on Memory in ApoE4 Carriers

Soccer Headers Might Be More Risky for APOE4 Genotype Carriers

Pointed ‘Tackle Can Wait’ TV ad hits amid sobering new CTE study’s stats

Every 2.6 Years of Playing American Football Doubles Risk of Devastating Brain Disease

NFL Stars' Risk of Developing the Degenerative Brain Disease CTE Soars by a THIRD Every Year They Play, Study Finds

Scary: Study Finds Every Year of Tackle Football Raises Chances of CTE 30%

NFL stars’ risk of developing the degenerative brain disease CTE soars by a THIRD every year they play, study finds

CTE Risk Goes Up 30% For Each Year Of Playing Football

BU Research Finds Link Between Playing Football and CTE

CTE Risk in Football Players Doubles Every Five Years, New Study Finds

CTE Risk More Than Doubles after Just Three Years of Playing Football

CTE Risk, Severity Increases With Years Playing Football, Study Shows

College Football Season Is Here. Will Universities Continue To Ignore The Risk Of Brain Damage?

New Jersey Unveils New Limits on High School Football Practices

Cannabis Studied to Treat Conditions from Football-Related Brain Trauma

Why We Still Don’t Know How Many NFL Players Have CTE

What's the Risk of Chronic Traumatic Encephalopathy for NFL Players?

Some People May Have Increased CTE Risk Because Of Their Genes

Why Some People’s CTE Symptoms Are More Severe Than Others

Why do some people get CTE? It may be in their genes

Why Don't All Football Players Develop CTE? It May Be Genetics

MED Researchers: Youth Football Linked to Earlier Brain Problems