Validation of Lens Beta-Amyloid as a Novel Biomarker for Early Detection of Alzheimer's Disease at the Boston University Alzheimer's Disease Research
09/30/2023 - 06/30/2028 (Multi-PI)
PI: Jesse B. Mez, MD
NIH/National Institute on Aging
5R01AG077588-02

Boston University Alzheimer's Disease Research Center
08/15/2021 - 06/30/2026 (Key Person)
PI: Ann C. McKee, MD
NIH/National Institute on Aging
5P30AG072978-03

Protocol number BAN2401-G000-303: AHEAD 3-45 Study: A Placebo-Controlled, Double-Blind, Parallel-Treatment Arm, 216 Week Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Subject
01/01/2020 - 12/31/2024 (PI of Sub-Project / SP)
University of Southern California Eisai, Inc


Leveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD)
03/15/2019 - 11/30/2024 (Multi-PI)
PI: Jesse B. Mez, MD
Icahn School of Medicine at Mount Sinai NIH NIA
5R01AG061028-05S1

Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium
09/30/2021 - 08/31/2024 (Subcontract PI)
Vanderbilt University Medical Center NIH NIA
5U24AG074855-02

AHEAD Plasma Extension (APEX)
05/01/2023 - 04/30/2024 (Subcontract PI)
University of Southern California NIH NIA
5R01AG053798-05

Leveraging the Framingham Study to Investigate Relationships between Traumatic Brain Injury, Military Service, Alzheimer's Disease and Related Dementias
09/01/2018 - 08/31/2023 (PI)
Department of Defense/Army Medical Research Acquisition Activity


ADNI Psychometrics
12/01/2017 - 03/31/2023 (Subcontract PI)
University of Washington NIH NIA
5R01AG029672-10

Genetic Architecture of Memory and Executive Functioning in Alzheimer's Disease
09/01/2014 - 05/31/2019 (Co-Investigator)
University of Washington NIH NIA
5R01AG042437-04

Genetic and Neuropsychological Heterogeneity in Alzheimer's Disease
08/15/2014 - 05/31/2019 (PI)
NIH/National Institute on Aging
5K23AG046377-05

Showing 10 of 12 results. Show All Results

1. Adams JW, Kirsch D, Calderazzo SM, Tuz-Zahra F, Tripodis Y, Mez J, Alosco ML, Alvarez VE, Huber BR, Kubilus C, Cormier KA, Nicks R, Uretsky M, Nair E, Kuzyk E, Aytan N, Cherry JD, Crary JF, Daneshvar DH, Nowinski CJ, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, McKee AC, Stein TD. Substantia Nigra Pathology, Contact Sports Play, and Parkinsonism in Chronic Traumatic Encephalopathy. JAMA Neurol. 2024 Sep 01; 81(9):916-924.View Related Profiles.

   McKee, Ann
   Huber, Bertrand
   Dwyer, Brigid
   Nowinski, Christopher
   Daneshvar, Daniel
   Katz, Douglas
   Mez, Jesse
   Cherry, Jonathan
   Goldstein, Lee
   Alosco, Michael
   Aytan, Nurgul
   Stern, Robert
   Stein, Thor
   Alvarez, Victor
   Tripodis, Yorghos
   

   PMID: 39008284; PMCID: PMC11250391; DOI: 10.1001/jamaneurol.2024.2166;
2. Asken BM, Bove JM, Bauer RM, Tanner JA, Casaletto KB, Staffaroni AM, VandeVrede L, Alosco ML, Mez JB, Stern RA, Miller BL, Grinberg LT, Boxer AL, Gorno-Tempini ML, Rosen HJ, Rabinovici GD, Kramer JH. Clinical implications of head trauma in frontotemporal dementia and primary progressive aphasia. Alzheimers Res Ther. 2024 Aug 29; 16(1):193.View Related Profiles.

   Mez, Jesse
   Alosco, Michael
   Stern, Robert
   

   PMID: 39210451; PMCID: PMC11363650; DOI: 10.1186/s13195-024-01553-1;
3. Jung LB, Wiegand TLT, Tuz-Zahra F, Tripodis Y, Iliff JJ, Piantino J, Arciniega H, Kim CL, Pankatz L, Bouix S, Lin AP, Alosco ML, Daneshvar DH, Mez J, Sepehrband F, Rathi Y, Pasternak O, Coleman MJ, Adler CH, Bernick C, Balcer L, Cummings JL, Reiman EM, Stern RA, Shenton ME, Koerte IK. Repetitive Head Impacts and Perivascular Space Volume in Former American Football Players. JAMA Netw Open. 2024 Aug 01; 7(8):e2428687.View Related Profiles.

   Daneshvar, Daniel
   Mez, Jesse
   Alosco, Michael
   Stern, Robert
   Tripodis, Yorghos
   

   PMID: 39186275
4. Akhter-Khan SC, Tao Q, Ang TFA, Karjadi C, Itchapurapu IS, Libon DJ, Alosco M, Mez J, Qiu WQ, Au R. Cerebral Microbleeds in Different Brain Regions and Their Associations With the Digital Clock-Drawing Test: Secondary Analysis of the Framingham Heart Study. J Med Internet Res. 2024 Jul 29; 26:e45780.View Related Profiles.

   Itchapurapu, Indira Swetha
   Mez, Jesse
   Alosco, Michael
   Tao, Qiushan
   Au, Rhoda
   Ang, Ting Fang Alvin
   

   PMID: 39073857; PMCID: PMC11319892; DOI: 10.2196/45780;
5. Kang M, Li C, Mahajan A, Spat-Lemus J, Durape S, Chen J, Gurnani AS, Devine S, Auerbach SH, Ang TFA, Sherva R, Qiu WQ, Lunetta KL, Au R, Farrer LA, Mez J. Subjective Cognitive Decline Plus and Longitudinal Assessment and Risk for Cognitive Impairment. JAMA Psychiatry. 2024 Jul 03.View Related Profiles.

   Gurnani, Ashita
   Mez, Jesse
   Lunetta, Kathryn
   Farrer, Lindsay
   Au, Rhoda
   Sherva, Richard
   Auerbach, Sanford
   Devine, Sherral
   

   PMID: 38959008; PMCID: PMC11223054; DOI: 10.1001/jamapsychiatry.2024.1678;
6. Culhane JE, Jackson CE, Tripodis Y, Nowinski CJ, Dams-O'Connor K, Pettway E, Uretsky M, Abdolmohammadi B, Nair E, Martin B, Palmisano J, Katz DI, Dwyer B, Daneshvar DH, Goldstein LE, Kowall NW, Cantu RC, Stern RA, Huber BR, Crary JF, Mez J, Stein TD, McKee AC, Alosco ML. Lack of Association of Informant-Reported Traumatic Brain Injury and Chronic Traumatic Encephalopathy. J Neurotrauma. 2024 Jun; 41(11-12):1399-1408.View Related Profiles.

   McKee, Ann
   Huber, Bertrand
   Dwyer, Brigid
   Nowinski, Christopher
   Daneshvar, Daniel
   Katz, Douglas
   Mez, Jesse
   Goldstein, Lee
   Alosco, Michael
   Kowall, Neil
   Stern, Robert
   Stein, Thor
   Tripodis, Yorghos
   

   PMID: 38445389; PMCID: PMC11339554; DOI: 10.1089/neu.2023.0391;
7. Wang Y, Huang J, Ang TFA, Zhu Y, Tao Q, Mez J, Alosco M, Denis GV, Belkina A, Gurnani A, Ross M, Gong B, Han J, Lunetta KL, Stein TD, Au R, Farrer LA, Zhang X, Qiu WQ. The association between circulating CD34+CD133+ endothelial progenitor cells and reduced risk of Alzheimer's disease in the Framingham Heart Study. Explor Med. 2024; 5(2):193-214.View Related Profiles.

   Belkina, Anna
   Gurnani, Ashita
   Denis, Gerald
   Mez, Jesse
   Lunetta, Kathryn
   Farrer, Lindsay
   Alosco, Michael
   Tao, Qiushan
   Au, Rhoda
   Stein, Thor
   Ang, Ting Fang Alvin
   

   PMID: 38854406; PMCID: PMC11160969; DOI: 10.37349/emed.2024.00216;
8. Banks SJ, Yhang E, Tripodis Y, Su Y, Protas H, Adler CH, Balcer LJ, Bernick C, Mez JB, Palmisano J, Barr WB, Wethe JV, Dodick DW, Mcclean MD, Martin B, Hartlage K, Turner A, Turner RW, Malhotra A, Colman M, Pasternak O, Lin AP, Koerte IK, Bouix S, Cummings JL, Shenton ME, Reiman EM, Stern RA, Alosco ML. Clinical Outcomes and Tau Pathology in Retired Football Players: Associations With Diagnosed and Witnessed Sleep Apnea. Neurol Clin Pract. 2024 Apr; 14(2):e200263.View Related Profiles.

   Mez, Jesse
   Alosco, Michael
   McClean, Michael
   Stern, Robert
   Tripodis, Yorghos
   

   PMID: 38425491; PMCID: PMC10900387; DOI: 10.1212/CPJ.0000000000200263;
9. Alexander A, Alvarez VE, Huber BR, Alosco ML, Mez J, Tripodis Y, Nicks R, Katz DI, Dwyer B, Daneshvar DH, Martin B, Palmisano J, Goldstein LE, Crary JF, Nowinski C, Cantu RC, Kowall NW, Stern RA, Delalle I, McKee AC, Stein TD. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta Neuropathol. 2024 Feb 26; 147(1):45.View Related Profiles.

   McKee, Ann
   Huber, Bertrand
   Dwyer, Brigid
   Nowinski, Christopher
   Daneshvar, Daniel
   Katz, Douglas
   Delalle, Ivana
   Mez, Jesse
   Goldstein, Lee
   Alosco, Michael
   Kowall, Neil
   Stern, Robert
   Stein, Thor
   Alvarez, Victor
   Tripodis, Yorghos
   

   PMID: 38407651; PMCID: PMC11348287; DOI: 10.1007/s00401-024-02690-5;
10. Agrawal S, Leurgans SE, Barnes LL, Dams-O'Connor K, Mez J, Bennett DA, Schneider JA. Chronic traumatic encephalopathy and aging-related tau astrogliopathy in community-dwelling older persons with and without moderate-to-severe traumatic brain injury. J Neuropathol Exp Neurol. 2024 Feb 21; 83(3):181-193. PMID: 38300796; PMCID: PMC10880068; DOI: 10.1093/jnen/nlae007;

Showing 10 of 162 results. Show More

How severe was Aaron Hernandez's CTE? A new show looks at his life and violent behavior

Diagnosing CTE before death: families play a crucial role in advancing the science

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New Boston University study could help diagnose CTE before death

BU researchers publish ‘crucial’ study that could help diagnose CTE before death

BU researchers say they’re closer to diagnosing CTE during life, rather than after death

Boston University researchers may be closer to identifying CTE in living patients

New Boston University study may help develop way to diagnose CTE in living patients

Researchers get closer to diagnosing CTE in living patients

Researchers Are One Step Closer to Diagnosing CTE during Life, Rather Than after Death

New Research Suggests That Cumulative Force Of Head Blows, Not The Frequency Of Hits, Is A Better Predictor Of CTE

Force of hits, not just number, raises CTE risk

Which Football Players Face Highest Odds for Brain Disorder CTE? New Findings May Tell

Head Hits, Not Concussions, Tied to CTE

The Force of Blows to the Head, Not Just How Many, Raises Likelihood of CTE

For NHL Players, More Fighting on the Ice Is Linked to Shorter Lives

NHL commissioner disputes link between hockey and CTE brain disease

Can Football Fans Watch with a Clear Conscience?

New research suggests intensity of hits in sports, not years played, may be better predictor of devastating brain damage

Genetic Variation May Explain Differences in CTE Risk After Repetitive Head Impact

Genetic variant may increase risk for CTE severity among older individuals with repetitive head impacts

Boston University CTE study: Genes may play major role in CTE severity

Former football pros die at a faster rate than baseball veterans—and the reasons are surprising

More Years Playing Hockey, Higher Odds for CTE Linked to Head Injury

More Years of Ice Hockey Play Tied to Higher CTE Risk

Boston University scientists making progress in CTE research

Boston University scientists getting closer to diagnosing CTE in living people using MRI

MRI Might Spot Concussion-Linked CTE in Living Patient

MRI Might Spot Concussion-Linked CTE in Living Patients

BU Researchers: CTE Study Offers Potential Path For Diagnosing The Brain Disease Before Death

Each Year You Play Football Increases Your Chances of Developing CTE by 30 Percent

Soccer Heading Has Greater Impact on Memory in ApoE4 Carriers

Soccer Headers Might Be More Risky for APOE4 Genotype Carriers

Pointed ‘Tackle Can Wait’ TV ad hits amid sobering new CTE study’s stats

Every 2.6 Years of Playing American Football Doubles Risk of Devastating Brain Disease

Scary: Study Finds Every Year of Tackle Football Raises Chances of CTE 30%

NFL stars’ risk of developing the degenerative brain disease CTE soars by a THIRD every year they play, study finds

CTE Risk Goes Up 30% For Each Year Of Playing Football

BU Research Finds Link Between Playing Football and CTE

CTE Risk in Football Players Doubles Every Five Years, New Study Finds

CTE Risk More Than Doubles after Just Three Years of Playing Football

CTE Risk, Severity Increases With Years Playing Football, Study Shows

College Football Season Is Here. Will Universities Continue To Ignore The Risk Of Brain Damage?

New Jersey Unveils New Limits on High School Football Practices

Cannabis Studied to Treat Conditions from Football-Related Brain Trauma

Why We Still Don’t Know How Many NFL Players Have CTE

What's the Risk of Chronic Traumatic Encephalopathy for NFL Players?

Some People May Have Increased CTE Risk Because Of Their Genes

Why Some People’s CTE Symptoms Are More Severe Than Others

Why do some people get CTE? It may be in their genes

Why Don't All Football Players Develop CTE? It May Be Genetics

MED Researchers: Youth Football Linked to Earlier Brain Problems