Ian Rifkin | Profiles RNS

Ian R. Rifkin, MD, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Nephrology

MBBCh, University of the Witwatersrand
PhD, University of Cambridge
MSc, University of London

Websites

	Microbiology Faculty
	Boston Medical Center Provider Profile
	Immunology Training Program Faculty

ORCID : 0000-0002-2674-3991

Expertise includes: Immunology; Autoimmunity; Systemic lupus erythematosus; and Nephrology.

Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Virology, Immunology & Microbiology

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Tool-like receptors in Systemic Autoimmune Disease
02/11/2010 - 06/30/2014 (Subcontract PI)
University of Massachusetts, Worcester NIH NIAMS
5P01AR050256-11

Role of Toll-like Receptors in Dendritic Cell Activation by Chromatin-Containing Immune Complexes
08/01/2002 - 01/31/2007 (PI)
The Lupus Research Institute Inc

Toll-like Receptors in the Pathogenesis of SLE and Immunologically-Mediated Renal Disease
04/01/2002 - 12/31/2006 (Co-PI)
Coley Pharmaceutical Group

Lupus Nephritis Molecular Studies Using Transcriptomics
06/02/2022 - 06/02/2026 (PI)
Visterra, Inc.

Evaluation of gene expression at the single cell level in kidney biopsies and urine from patients with glomerulonephritis
07/01/2020 - 06/30/2024 (PI)
Chugai Pharmaceutical Co., Ltd

The Role of Interferon Regulatory Factor 5 in the Pathogenesis of SLE
09/01/2019 - 08/31/2023 (PI)
National Institute of Allergy and Infectious Diseases/NIH/DHHS
5R01AI130199-02

Dr. Rifkin _ Sanofi
04/20/2020 - 04/19/2023 (PI)
Sanofi US Services Inc.

Research Training in Nephrology
07/01/2015 - 06/30/2021 (Subcontract PI)
PI: Ian R. Rifkin, MD, PhD
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS NIH
5T32DK007053-46

Immunomodulator Identification in Systemic Lupus Erythematosus
12/02/2015 - 06/02/2021 (PI)
Merck

The role of innate immune system mediators and pathways in SLE pathogenesis
12/21/2015 - 12/20/2018 (PI)
Merck

Evaluation of antibodies for the treatment of autoimmune diseases
03/01/2016 - 04/30/2018 (PI)
Chugai Pharmaceutical, Co., Ltd.

Evaluating impact of Biogen IRAK 4 inhibitors on metabolism and generation of human plasmacytoid den
09/23/2013 - 09/30/2016 (PI)
Biogen, Inc

SLE-immune complex-mediated inflammatory cell activation: regulation by IRF5 and new effector discov
11/01/2012 - 08/31/2015 (PI)
Kyowa Hakko Kirin Co.

Showing 10 of 17 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2021	The Role of Interferon Regulatory Factor 5 in the Pathogenesis of SLE	5R01AI130199-05
2020	The Role of Interferon Regulatory Factor 5 in the Pathogenesis of SLE	5R01AI130199-04
2019	The Role of Interferon Regulatory Factor 5 in the Pathogenesis of SLE	5R01AI130199-03
2019	Research Training in Nephrology	5T32DK007053-46	48
2018	The Role of Interferon Regulatory Factor 5 in the Pathogenesis of SLE	5R01AI130199-02
2018	Research Training in Nephrology	3T32DK007053-45S1	48
2018	Research Training in Nephrology	5T32DK007053-45	48
2017	The Role of Interferon Regulatory Factor 5 in the Pathogenesis of SLE	1R01AI130199-01A1
2017	Research Training in Nephrology	5T32DK007053-44	48
2013	THE ROLE OF INTERFERON REGULATORY FACTOR 5 IN THE PATHOGENESIS OF SLE	5P01AR050256-11-6674	66

Showing 10 of 27 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Rhee CM, Kovesdy CP, Unruh M, Crowley S, Geller D, Goldfarb DS, Kraut J, Rastegar M, Rifkin IR, Kalantar-Zadeh K. Incremental hemodialysis transition in veterans and nonveterans with kidney failure. Curr Opin Nephrol Hypertens. 2025 Jan 01; 34(1):33-40. PMID: 39611277

Pellerin A, Tan Y, Lu S, Bonegio RG, Rifkin IR. Genetic Reduction of IRF5 Expression after Disease Initiation Reduces Disease in a Mouse Lupus Model by Impacting Systemic and End-Organ Pathogenic Pathways. J Immunol. 2023 Nov 01; 211(9):1308-1319.View Related Profiles.

Pellerin, Alex
Rifkin, Ian
Bonegio, Ramon
Tan, Ying

PMID: 37721418

Mattocks KM, Kroll-Desrosiers A, Crowley S, Tuozzo K, Rifkin I, Moore D, Walker L, Bonegio R. Using RE-AIM to examine implementation of a tele-nephrology program for veterans living in rural areas. Front Health Serv. 2023; 3:1205951.View Related Profiles.

Rifkin, Ian
Bonegio, Ramon

PMID: 37780402; PMCID: PMC10533984; DOI: 10.3389/frhs.2023.1205951;

Tatsumoto N, Saito S, Rifkin IR, Bonegio RG, Leal DN, Sen GC, Arditi M, Yamashita M. EGF-Receptor-Dependent TLR7 Signaling in Macrophages Promotes Glomerular Injury in Crescentic Glomerulonephritis. Lab Invest. 2023 Sep; 103(9):100190.View Related Profiles.

Rifkin, Ian
Bonegio, Ramon

PMID: 37268107; PMCID: PMC10527264; DOI: 10.1016/j.labinv.2023.100190;

Bhatnagar A, Ananthakrishan S, Rifkin I, Breu AC. A Veteran Presenting for Low Testosterone and Lower Urinary Tract Symptoms. Fed Pract. 2022 Oct; 39(10):406-409a.View Related Profiles.

Breu, Anthony
Rifkin, Ian

PMID: 36744013; PMCID: PMC9896365; DOI: 10.12788/fp.0326;

Pellerin A, Yasuda K, Cohen-Bucay A, Sandra V, Shukla P, Jr BKH, Nündel K, Viglianti GA, Xie Y, Klein U, Tan Y, Bonegio RG, Rifkin IR. Monoallelic IRF5 deficiency in B cells prevents murine lupus. JCI Insight. 2021 08 09; 6(15).View Related Profiles.

Pellerin, Alex
Horne, Barry
Viglianti, Gregory
Rifkin, Ian
Yasuda, Kei
Bonegio, Ramon
Tan, Ying

PMID: 34197340; PMCID: PMC8410043; DOI: 10.1172/jci.insight.141395;

Yuen RR, Steiner D, Pihl RMF, Chavez E, Olson A, Smith EL, Baird LA, Korkmaz F, Urick P, Sagar M, Berrigan JL, Gummuluru S, Corley RB, Quillen K, Belkina AC, Mostoslavsky G, Rifkin IR, Kataria Y, Cappione AJ, Gao W, Lin NH, Bhadelia N, Snyder-Cappione JE. Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection. Front Immunol. 2021; 12:614676.View Related Profiles.

Olson, Alex
Belkina, Anna
Steiner, Dylan
Korkmaz, Filiz
Mostoslavsky, Gustavo
Rifkin, Ian
Snyder-Cappione , Jennifer
Quillen, Karen
Sagar, Manish
Bhadelia, Nahid
Lin, Nina
Pihl, Riley
Corley, Ronald
Gummuluru, Suryaram
Kataria, Yachana

PMID: 33897682; PMCID: PMC8062931; DOI: 10.3389/fimmu.2021.614676;

Lee J, Zhang J, Chung YJ, Kim JH, Kook CM, González-Navajas JM, Herdman DS, Nürnberg B, Insel PA, Corr M, Mo JH, Tao A, Yasuda K, Rifkin IR, Broide DH, Sciammas R, Webster NJ, Raz E. Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses. Elife. 2020 02 04; 9.View Related Profiles.

Rifkin, Ian
Yasuda, Kei

PMID: 32014112; PMCID: PMC7000221; DOI: 10.7554/eLife.49416;

Lyle C, Richards S, Yasuda K, Napoleon MA, Walker J, Arinze N, Belghasem M, Vellard I, Yin W, Ravid JD, Zavaro E, Amraei R, Francis J, Phatak U, Rifkin IR, Rahimi N, Chitalia VC. c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth. Sci Rep. 2019 12 27; 9(1):20257.View Related Profiles.

Rifkin, Ian
Francis, Jean
Walker, Joshua
Yasuda, Kei
Belghasem, Mostafa
Rahimi, Nader
Arinze , Nkiruka
Phatak, Uma
Chitalia, Vipul
Yin, Wenqing

PMID: 31882749; PMCID: PMC6934810; DOI: 10.1038/s41598-019-56208-1;

Rifkin IR, Bonegio RG. Editorial: Podocytes as Active Participants in Lupus Nephritis. Arthritis Rheumatol. 2017 08; 69(8):1517-1520.View Related Profiles.

Rifkin, Ian
Bonegio, Ramon

PMID: 28544537

Showing 10 of 61 results. Show More

Choo MK, Sano Y, Kim C, Yasuda K, Li XD, Lin X, Stenzel-Poore M, Alexopoulou L, Ghosh S, Latz E, Rifkin IR, Chen ZJ, Stewart GC, Chong H, Park JM. TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects. J Exp Med. 2017 May 01; 214(5):1297-1311.View Related Profiles.

Rifkin, Ian
Yasuda, Kei

PMID: 28400473; PMCID: PMC5413331; DOI: 10.1084/jem.20161141;

Das A, Heesters BA, Bialas A, O'Flynn J, Rifkin IR, Ochando J, Mittereder N, Carlesso G, Herbst R, Carroll MC. Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses. Immunity. 2017 Jan 17; 46(1):106-119. PMID: 28099860; PMCID: PMC8140609; DOI: 10.1016/j.immuni.2016.12.014;

Duffau P, Menn-Josephy H, Cuda CM, Dominguez S, Aprahamian TR, Watkins AA, Yasuda K, Monach P, Lafyatis R, Rice LM, Kenneth Haines G, Gravallese EM, Baum R, Richez C, Perlman H, Bonegio RG, Rifkin IR. Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model. Arthritis Rheumatol. 2015 Dec; 67(12):3146-57.View Related Profiles.

Watkins, Amanda
Menn-Josephy, Hanni
Rifkin, Ian
Yasuda, Kei
Rice, Lisa
Monach, Paul
Bonegio, Ramon
Lafyatis, Robert
Aprahamian, Tamar

PMID: 26315890; PMCID: PMC4661118; DOI: 10.1002/art.39321;

Aprahamian TR, Zhong X, Amir S, Binder CJ, Chiang LK, Al-Riyami L, Gharakhanian R, Harnett MM, Harnett W, Rifkin IR. The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model. Int J Parasitol. 2015 Mar; 45(4):203-7.View Related Profiles.

Rifkin, Ian
Aprahamian, Tamar
Zhong, Xuemei

PMID: 25666929; PMCID: PMC4355381; DOI: 10.1016/j.ijpara.2014.12.006;

Watkins AA, Yasuda K, Wilson GE, Aprahamian T, Xie Y, Maganto-Garcia E, Shukla P, Oberlander L, Laskow B, Menn-Josephy H, Wu Y, Duffau P, Fried SK, Lichtman AH, Bonegio RG, Rifkin IR. IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis. J Immunol. 2015 Feb 15; 194(4):1467-79.View Related Profiles.

Watkins, Amanda
Menn-Josephy, Hanni
Rifkin, Ian
Yasuda, Kei
Bonegio, Ramon
Fried, Susan
Aprahamian, Tamar
Wu, Yuanyuan

PMID: 25595782; PMCID: PMC4323680; DOI: 10.4049/jimmunol.1402807;

Mathes AL, Rice L, Affandi AJ, DiMarzio M, Rifkin IR, Stifano G, Christmann RB, Lafyatis R. CpGB DNA activates dermal macrophages and specifically recruits inflammatory monocytes into the skin. Exp Dermatol. 2015 Feb; 24(2):133-9.View Related Profiles.

Stifano, Giuseppina
Rifkin, Ian
Rice, Lisa
Lafyatis, Robert

PMID: 25425469; PMCID: PMC4474603; DOI: 10.1111/exd.12603;

Tan Y, Watkins AA, Freeman BB, Meyers JA, Rifkin IR, Lerner A. Inhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells. J Immunol. 2015 Jan 1; 194(1):101-12.View Related Profiles.

Lerner, Adam
Watkins, Amanda
Rifkin, Ian
Meyers, John
Tan, Ying

PMID: 25416804; PMCID: PMC4333002; DOI: 10.4049/jimmunol.1401854;

Ericson JA, Duffau P, Yasuda K, Ortiz-Lopez A, Rothamel K, Rifkin IR, Monach PA. Gene expression during the generation and activation of mouse neutrophils: implication of novel functional and regulatory pathways. PLoS One. 2014; 9(10):e108553.View Related Profiles.

Rifkin, Ian
Yasuda, Kei
Monach, Paul

PMID: 25279834; PMCID: PMC4184787; DOI: 10.1371/journal.pone.0108553;

Yasuda K, Watkins AA, Kochar GS, Wilson GE, Laskow B, Richez C, Bonegio RG, Rifkin IR. Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2. PLoS One. 2014; 9(7):e103478.View Related Profiles.

Watkins, Amanda
Rifkin, Ian
Yasuda, Kei
Bonegio, Ramon

PMID: 25076492; PMCID: PMC4116215; DOI: 10.1371/journal.pone.0103478;

Aprahamian TR, Bonegio RG, Weitzner Z, Gharakhanian R, Rifkin IR. Peroxisome proliferator-activated receptor gamma agonists in the prevention and treatment of murine systemic lupus erythematosus. Immunology. 2014 Jul; 142(3):363-73.View Related Profiles.

Rifkin, Ian
Bonegio, Ramon
Aprahamian, Tamar

PMID: 24456224; PMCID: PMC4080952; DOI: 10.1111/imm.12256;

Watkins AA, Bonegio RG, Rifkin IR. Evaluating the role of nucleic acid antigens in murine models of systemic lupus erythematosus. Methods Mol Biol. 2014; 1169:143-58.View Related Profiles.

Watkins, Amanda
Rifkin, Ian
Bonegio, Ramon

PMID: 24957237; DOI: 10.1007/978-1-4939-0882-0_14;

Richez C, Richards RJ, Duffau P, Weitzner Z, Andry CD, Rifkin IR, Aprahamian T. The effect of mycophenolate mofetil on disease development in the gld.apoE (-/-) mouse model of accelerated atherosclerosis and systemic lupus erythematosus. PLoS One. 2013; 8(4):e61042.View Related Profiles.

Rifkin, Ian
Aprahamian, Tamar

PMID: 23577189; PMCID: PMC3620051; DOI: 10.1371/journal.pone.0061042;

Yasuda K, Nündel K, Watkins AA, Dhawan T, Bonegio RG, Ubellacker JM, Marshak-Rothstein A, Rifkin IR. Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2. Int Immunol. 2013 May; 25(5):295-306.View Related Profiles.

Watkins, Amanda
Marshak-Rothstein, Ann
Rifkin, Ian
Yasuda, Kei
Bonegio, Ramon

PMID: 23291967; PMCID: PMC3631000; DOI: 10.1093/intimm/dxs114;

Richez C, Blanco P, Rifkin I, Moreau JF, Schaeverbeke T. Role for toll-like receptors in autoimmune disease: the example of systemic lupus erythematosus. Joint Bone Spine. 2011 Mar; 78(2):124-30. PMID: 20961794; DOI: 10.1016/j.jbspin.2010.09.005;

Richez C, Barnetche T, Miceli-Richard C, Blanco P, Moreau JF, Rifkin I, Schaeverbeke T. Role for interferon regulatory factors in autoimmunity. Joint Bone Spine. 2010 Dec; 77(6):525-31. PMID: 20863736; DOI: 10.1016/j.jbspin.2010.08.005;

Farina GA, York MR, Di Marzio M, Collins CA, Meller S, Homey B, Rifkin IR, Marshak-Rothstein A, Radstake TR, Lafyatis R. Poly(I:C) drives type I IFN- and TGFß-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J Invest Dermatol. 2010 Nov; 130(11):2583-93.View Related Profiles.

Marshak-Rothstein, Ann
Farina, Giuseppina
Rifkin, Ian
York, Michael
Lafyatis, Robert

PMID: 20613770; PMCID: PMC3086558; DOI: 10.1038/jid.2010.200;

Richez C, Yasuda K, Bonegio RG, Watkins AA, Aprahamian T, Busto P, Richards RJ, Liu CL, Cheung R, Utz PJ, Marshak-Rothstein A, Rifkin IR. IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus. J Immunol. 2010 Jan 15; 184(2):796-806.View Related Profiles.

Watkins, Amanda
Marshak-Rothstein, Ann
Rifkin, Ian
Yasuda, Kei
Bonegio, Ramon
Aprahamian, Tamar

PMID: 20007534; PMCID: PMC2858062; DOI: 10.4049/jimmunol.0901748;

Yasuda K, Richez C, Uccellini MB, Richards RJ, Bonegio RG, Akira S, Monestier M, Corley RB, Viglianti GA, Marshak-Rothstein A, Rifkin IR. Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes. J Immunol. 2009 Sep 1; 183(5):3109-17.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory
Rifkin, Ian
Yasuda, Kei
Bonegio, Ramon
Corley, Ronald

PMID: 19648272; PMCID: PMC2860771; DOI: 10.4049/jimmunol.0900399;

Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol. 2009 Aug 1; 183(3):1569-76.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian
van Seventer, Jean
Connor, John
Yasuda, Kei

PMID: 19587008; PMCID: PMC2929820; DOI: 10.4049/jimmunol.0803899;

Lenert P, Yasuda K, Busconi L, Nelson P, Fleenor C, Ratnabalasuriar RS, Nagy PL, Ashman RF, Rifkin IR, Marshak-Rothstein A. DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo. Arthritis Res Ther. 2009; 11(3):R79.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian
Yasuda, Kei

PMID: 19476613; PMCID: PMC2714127; DOI: 10.1186/ar2710;

Richez C, Yasuda K, Watkins AA, Akira S, Lafyatis R, van Seventer JM, Rifkin IR. TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming. J Immunol. 2009 Jan 15; 182(2):820-8.View Related Profiles.

Watkins, Amanda
Rifkin, Ian
van Seventer, Jean
Yasuda, Kei
Lafyatis, Robert

PMID: 19124725; PMCID: PMC2858919; DOI: 10.4049/jimmunol.182.2.820;

Aprahamian T, Bonegio RG, Richez C, Yasuda K, Chiang LK, Sato K, Walsh K, Rifkin IR. The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. J Immunol. 2009 Jan 1; 182(1):340-6.View Related Profiles.

Rifkin, Ian
Yasuda, Kei
Bonegio, Ramon
Aprahamian, Tamar

PMID: 19109165; PMCID: PMC2841959; DOI: 10.4049/jimmunol.182.1.340;

Yasuda K, Richez C, Maciaszek JW, Agrawal N, Akira S, Marshak-Rothstein A, Rifkin IR. Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production. J Immunol. 2007 Jun 1; 178(11):6876-85.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian
Yasuda, Kei

PMID: 17513736

Marshak-Rothstein A, Rifkin IR. Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease. Annu Rev Immunol. 2007; 25:419-41.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian

PMID: 17378763

Bijol V, Agrawal N, Abernethy VE, Rifkin IR, Nosé V, Rennke HG. A 57-year-old woman with recently diagnosed SLE, proteinuria, and microhematuria. Am J Kidney Dis. 2006 Dec; 48(6):1004-8. PMID: 17162159

Aprahamian T, Bonegio R, Rizzo J, Perlman H, Lefer DJ, Rifkin IR, Walsh K. Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model. J Immunol. 2006 Sep 1; 177(5):3028-34.View Related Profiles.

Rifkin, Ian
Bonegio, Ramon
Aprahamian, Tamar

PMID: 16920939; PMCID: PMC2752011; DOI: 10.4049/jimmunol.177.5.3028;

Beaudette-Zlatanova BC, Ling T, Shlomchik MJ, Marshak-Rothstein A, Rifkin IR. B cells and dendritic cells from V kappa 8 light chain transgenic mice activate MRL-lpr/gld CD4+ T cells. J Immunol. 2006 Jul 1; 177(1):45-52.View Related Profiles.

Marshak-Rothstein, Ann
Beaudette-Zlatanova, Britte
Rifkin, Ian

PMID: 16785497

Agrawal N, Chiang LK, Rifkin IR. Lupus nephritis. Semin Nephrol. 2006 Mar; 26(2):95-104. PMID: 16530602

Busconi L, Lau CM, Tabor AS, Uccellini MB, Ruhe Z, Akira S, Viglianti GA, Rifkin IR, Marshak-Rothstein A. DNA and RNA autoantigens as autoadjuvants. J Endotoxin Res. 2006; 12(6):379-84.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory
Rifkin, Ian

PMID: 17254393

Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, Christensen SR, Shlomchik MJ, Viglianti GA, Rifkin IR, Marshak-Rothstein A. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med. 2005 Nov 7; 202(9):1171-7.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory
Rifkin, Ian

PMID: 16260486; PMCID: PMC2213226; DOI: 10.1084/jem.20050630;

Rifkin IR, Leadbetter EA, Busconi L, Viglianti G, Marshak-Rothstein A. Toll-like receptors, endogenous ligands, and systemic autoimmune disease. Immunol Rev. 2005 Apr; 204:27-42.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory
Rifkin, Ian

PMID: 15790348

Marshak-Rothstein A, Busconi L, Rifkin IR, Viglianti GA. The stimulation of Toll-like receptors by nuclear antigens: a link between apoptosis and autoimmunity. Rheum Dis Clin North Am. 2004 Aug; 30(3):559-74, ix.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory
Rifkin, Ian

PMID: 15261341

Boulé MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med. 2004 Jun 21; 199(12):1631-40.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian

PMID: 15197227; PMCID: PMC2212813

Aprahamian T, Rifkin I, Bonegio R, Hugel B, Freyssinet JM, Sato K, Castellot JJ, Walsh K. Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J Exp Med. 2004 Apr 19; 199(8):1121-31.View Related Profiles.

Rifkin, Ian
Walsh, Kenneth
Bonegio, Ramon
Aprahamian, Tamar

PMID: 15096538; PMCID: PMC2211887

Marshak-Rothstein A, Busconi L, Lau CM, Tabor AS, Leadbetter EA, Akira S, Krieg AM, Lipford GB, Viglianti GA, Rifkin IR. Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells. J Endotoxin Res. 2004; 10(4):247-51.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory
Rifkin, Ian

PMID: 15373969

Rifkin IR, Marshak-Rothstein A. T-bet: the Toll-bridge to class-switch recombination? Nat Immunol. 2003 Jul; 4(7):650-2.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian

PMID: 12830144

Leadbetter EA, Rifkin IR, Marshak-Rothstein A. Toll-like receptors and activation of autoreactive B cells. Curr Dir Autoimmun. 2003; 6:105-22.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian

PMID: 12408049

Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 2002 Apr 11; 416(6881):603-7.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian

PMID: 11948342

Rifkin IR, Leadbetter EA, Beaudette BC, Kiani C, Monestier M, Shlomchik MJ, Marshak-Rothstein A. Immune complexes present in the sera of autoimmune mice activate rheumatoid factor B cells. J Immunol. 2000 Aug 1; 165(3):1626-33.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian

PMID: 10903773

Zhu B, Beaudette BC, Rifkin IR, Marshak-Rothstein A. Double mutant MRL-lpr/lpr-gld/gld cells fail to trigger lpr-graft-versus-host disease in syngeneic wild-type recipient mice, but can induce wild-type B cells to make autoantibody. Eur J Immunol. 2000 Jun; 30(6):1778-84.View Related Profiles.

Marshak-Rothstein, Ann
Beaudette-Zlatanova, Britte
Rifkin, Ian

PMID: 10898516

Rifkin IR, Marshak-Rothstein A. Fas and Fas ligand in autoimmunity. Curr Dir Autoimmun. 1999; 1:31-55.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian

PMID: 11791447

Rifkin IR, Channavajhala PL, Kiefer HL, Carmack AJ, Landesman-Bollag E, Beaudette BC, Jersky B, Salant DJ, Ju ST, Marshak-Rothstein A, Seldin DC. Acceleration of lpr lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha. J Immunol. 1998 Nov 15; 161(10):5164-70.View Related Profiles.

Marshak-Rothstein, Ann
Beaudette-Zlatanova, Britte
Seldin, David
Salant, David
Landesman, Esther
Rifkin, Ian

PMID: 9820486

McHugh S, Deighton J, Rifkin I, Ewan P. Kinetics and functional implications of Th1 and Th2 cytokine production following activation of peripheral blood mononuclear cells in primary culture. Eur J Immunol. 1996 Jun; 26(6):1260-5. PMID: 8647202

McHugh SM, Rifkin IR, Deighton J, Wilson AB, Lachmann PJ, Lockwood CM, Ewan PW. The immunosuppressive drug thalidomide induces T helper cell type 2 (Th2) and concomitantly inhibits Th1 cytokine production in mitogen- and antigen-stimulated human peripheral blood mononuclear cell cultures. Clin Exp Immunol. 1995 Feb; 99(2):160-7. PMID: 7851006; PMCID: PMC1534314

Lai KN, Leung JC, Rifkin I, Lockwood CM. Effect of anti-neutrophil cytoplasm autoantibodies on the intracellular calcium concentration of human neutrophils. Lab Invest. 1994 Feb; 70(2):152-62. PMID: 7908069

Parsons V, Baldwin D, Moniz C, Marsden J, Ball E, Rifkin I. Successful control of hyperparathyroidism in patients on continuous ambulatory peritoneal dialysis using magnesium carbonate and calcium carbonate as phosphate binders. Nephron. 1993; 63(4):379-83. PMID: 8459870

Keogan MT, Rifkin I, Ronda N, Lockwood CM, Brown DL. Anti-neutrophil cytoplasm antibodies (ANCA) increase neutrophil adhesion to cultured human endothelium. Adv Exp Med Biol. 1993; 336:115-9. PMID: 7905228

Maheshwari HG, Rifkin I, Butler J, Norman M. Growth hormone binding protein in patients with renal failure. Acta Endocrinol (Copenh). 1992 Dec; 127(6):485-8. PMID: 1492536

Deane C, Cowan N, Giles J, Walters H, Rifkin I, Severn A, Parsons V. Arteriovenous fistulas in renal transplants: color Doppler ultrasound observations. Urol Radiol. 1992; 13(4):211-7. PMID: 1598744

Bateman AM, Larner AJ, McCartney SA, Rifkin IR. Rhabdomyolysis associated with lithium-induced hyperosmolal state. Nephrol Dial Transplant. 1991; 6(3):203-5. PMID: 1907725

Sacks LV, Rifkin IR. Mirror image arrangement of the abdominal organs with a left-sided morphologically normal heart. Br Heart J. 1987 Nov; 58(5):534-6. PMID: 3676045; PMCID: PMC1277354

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 61 publications over 28 distinct years, with a maximum of 6 publications in 2009

Bar chart showing 61 publications over 28 distinct years, with a maximum of 6 publications in 2009

Year	Publications
1987	1
1991	1
1992	2
1993	2
1994	1
1995	1
1996	1
1998	1
1999	1
2000	2
2002	1
2003	2
2004	4
2005	2
2006	5
2007	2
2009	6
2010	3
2013	2
2014	4
2015	5
2017	3
2019	1
2020	1
2021	2
2022	1
2023	3
2024	1

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

atherosclerosis
Autoimmunity
interferon regulatory factors
systemic lupus erythematosus
Toll like receptors

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