Finn Hawkins | Profiles RNS

Finn Hawkins, MBBCh

Assistant Professor

Boston University School of Medicine

Dept of Medicine

Pulmonary, Allergy, Sleep & Critical Care Medicine

MBBCh, National University of Ireland

Websites

	ResearchGate
	LinkedIn

ORCID : 0000-0002-2246-6448

Dr. Hawkins is a Principal Investigator (P.I.) in the Center for Regenerative Medicine and The Pulmonary Center. His research focus is studying human lung development and disease using human induced pluripotent stem cells (iPSCs). Dr. Hawkins is currently using iPSC technology to study airway biology with a focus on Cystic Fibrosis.

Member
Boston University
Pulmonary Center

Member
Boston University
Center for Regenerative Medicine

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

BU Research

iPSC-Derived Airway Basal Cells to Model Human Airway Development and Disease
09/01/2018 - 08/31/2023 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL139799-02

Generation of functional lung stem cells from human iPSCs
07/01/2019 - 06/30/2021 (Multi-PI)
PI: Finn Hawkins, MBBCh
NIH/National Heart, Lung, and Blood Institute
1U01HL148692-01

Refining stage-specific patterning to efficiently generate basal cells from iPSCs
07/01/2019 - 01/31/2020 (PI)
Cystic Fibrosis Foundation

Creating the W1282X CFTR Airway Epithelial Cell Toolbox
07/03/2017 - 01/31/2020 (Subcontract PI)
University of North Carolina at Chapel Hill Emilys Entourage

Personalized Drug Predictions For CF Using iPSC-derived Bronchospheres
04/01/2017 - 03/31/2019 (PI)
Cystic Fibrosis Foundation

Personalized Assessment of CFTR Function in iPSC-derived Lung Organoids
01/01/2016 - 12/31/2016 (PI)
Cystic Fibrosis Foundation

Reconstructing Lung Epithelium with Gene-corrected Disease-specific iPS cells
07/01/2012 - 06/30/2014 (Co-PI)
PI: Darrell Nelson Kotton, MD
American Lung Association

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

King NE, Suzuki S, Barillà C, Hawkins FJ, Randell SH, Reynolds SD, Stripp BR, Davis BR. Correction of Airway Stem Cells: Genome Editing Approaches for the Treatment of Cystic Fibrosis. Hum Gene Ther. 2020 Sep; 31(17-18):956-972. PMID: 32741223

Huang J, Hume AJ, Abo KM, Werder RB, Villacorta-Martin C, Alysandratos KD, Beermann ML, Simone-Roach C, Olejnik J, Suder EL, Bullitt E, Hinds A, Sharma A, Bosmann M, Wang R, Hawkins F, Burks EJ, Saeed M, Wilson AA, Mühlberger E, Kotton DN. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. bioRxiv. 2020 Jun 30.View Related Profiles.

Hume, Adam
Wilson, Andrew
Kotton, Darrell
Muhlberger, Elke
Burks, Eric
Bullitt, Esther
Hawkins, Finn
Olejnik, Judith
Bosmann, Markus
Saeed, Mohsan
Werder, Rhiannon Bree

PMID: 32637964

Abo KM, Ma L, Matte T, Huang J, Alysandratos KD, Werder RB, Mithal A, Beermann ML, Lindstrom-Vautrin J, Mostoslavsky G, Ikonomou L, Kotton DN, Hawkins F, Wilson A, Villacorta-Martin C. Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors. bioRxiv. 2020 Jun 04.View Related Profiles.

Wilson, Andrew
Kotton, Darrell
Hawkins, Finn
Mostoslavsky, Gustavo
Huang, Jessie
Werder, Rhiannon Bree

PMID: 32577635

Wang R, McCauley KB, Kotton DN, Hawkins F. Differentiation of human airway-organoids from induced pluripotent stem cells (iPSCs). Methods Cell Biol. 2020; 159:95-114.View Related Profiles.

Kotton, Darrell
Hawkins, Finn

PMID: 32586451

De Santi C, Fernández Fernández E, Gaul R, Vencken S, Glasgow A, Oglesby IK, Hurley K, Hawkins F, Mitash N, Mu F, Raoof R, Henshall DC, Cutrona MB, Simpson JC, Harvey BJ, Linnane B, McNally P, Cryan SA, MacLoughlin R, Swiatecka-Urban A, Greene CM. Precise Targeting of miRNA Sites Restores CFTR Activity in CF Bronchial Epithelial Cells. Mol Ther. 2020 04 08; 28(4):1190-1199. PMID: 32059764

Mithal A, Capilla A, Heinze D, Berical A, Villacorta-Martin C, Vedaie M, Jacob A, Abo K, Szymaniak A, Peasley M, Stuffer A, Mahoney J, Kotton DN, Hawkins F, Mostoslavsky G. Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells. Nat Commun. 2020 01 10; 11(1):215.View Related Profiles.

Szymaniak, Aleksander
Berical, Andrew
Jacob, Anjali
Heinze, Dar
Kotton, Darrell
Hawkins, Finn
Mostoslavsky, Gustavo

PMID: 31924806

Jacob A, Vedaie M, Roberts DA, Thomas DC, Villacorta-Martin C, Alysandratos KD, Hawkins F, Kotton DN. Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells. Nat Protoc. 2019 12; 14(12):3303-3332.View Related Profiles.

Jacob, Anjali
Kotton, Darrell
Hawkins, Finn

PMID: 31732721

Ryan AL, Ikonomou L, Atarod S, Bölükbas DA, Collins J, Freishtat R, Hawkins F, Gilpin SE, Uhl FE, Uriarte JJ, Weiss DJ, Wagner DE. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases 2017. An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2019 10; 61(4):429-439.View Related Profiles.

Hawkins, Finn
Ikonomou, Laertis
Atarod, Sadaf

PMID: 31573338

Berical A, Lee RE, Randell SH, Hawkins F. Challenges Facing Airway Epithelial Cell-Based Therapy for Cystic Fibrosis. Front Pharmacol. 2019; 10:74.View Related Profiles.

Berical, Andrew
Hawkins, Finn

PMID: 30800069

Hawkins FJ, Kotton DN. Pulmonary Ionocytes Challenge the Paradigm in Cystic Fibrosis. Trends Pharmacol Sci. 2018 10; 39(10):852-854.View Related Profiles.

Kotton, Darrell
Hawkins, Finn

PMID: 30213439

Showing 10 of 24 results. Show More

McCauley KB, Hawkins F, Kotton DN. Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2018 05; 45(1):e51.View Related Profiles.

Kotton, Darrell
Hawkins, Finn

PMID: 30040246

McCauley KB, Alysandratos KD, Jacob A, Hawkins F, Caballero IS, Vedaie M, Yang W, Slovik KJ, Morley M, Carraro G, Kook S, Guttentag SH, Stripp BR, Morrisey EE, Kotton DN. Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium. Stem Cell Reports. 2018 05 08; 10(5):1579-1595.View Related Profiles.

Jacob, Anjali
Kotton, Darrell
Hawkins, Finn
Alysandratos, Kostas

PMID: 29657097

Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na CL, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Ochs M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, Wambach J, Whitsett JA, Cole FS, Morrisey EE, Guttentag SH, Beers MF, Kotton DN. Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells. Cell Stem Cell. 2017 Oct 05; 21(4):472-488.e10.View Related Profiles.

Jacob, Anjali
Kotton, Darrell
Hawkins, Finn
Traber, Katrina
Quinton, Lee

PMID: 28965766

Serra M, Alysandratos KD, Hawkins F, McCauley KB, Jacob A, Choi J, Caballero IS, Vedaie M, Kurmann AA, Ikonomou L, Hollenberg AN, Shannon JM, Kotton DN. Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification. Development. 2017 11 01; 144(21):3879-3893.View Related Profiles.

Jacob, Anjali
Kotton, Darrell
Hawkins, Finn
Alysandratos, Kostas
Ikonomou, Laertis

PMID: 28947536

Hawkins F, Kramer P, Jacob A, Driver I, Thomas DC, McCauley KB, Skvir N, Crane AM, Kurmann AA, Hollenberg AN, Nguyen S, Wong BG, Khalil AS, Huang SX, Guttentag S, Rock JR, Shannon JM, Davis BR, Kotton DN. Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells. J Clin Invest. 2017 Jun 01; 127(6):2277-2294.View Related Profiles.

Jacob, Anjali
Kotton, Darrell
Hawkins, Finn
Rock, Jason

PMID: 28463226

McCauley KB, Hawkins F, Serra M, Thomas DC, Jacob A, Kotton DN. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling. Cell Stem Cell. 2017 Jun 01; 20(6):844-857.e6.View Related Profiles.

Jacob, Anjali
Kotton, Darrell
Hawkins, Finn

PMID: 28366587; DOI: 10.1016/j.stem.2017.03.001;

Kurmann AA, Serra M, Hawkins F, Rankin SA, Mori M, Astapova I, Ullas S, Lin S, Bilodeau M, Rossant J, Jean JC, Ikonomou L, Deterding RR, Shannon JM, Zorn AM, Hollenberg AN, Kotton DN. Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells. Cell Stem Cell. 2015 Nov 5; 17(5):527-42.View Related Profiles.

Kotton, Darrell
Hawkins, Finn
Ikonomou, Laertis

PMID: 26593959; PMCID: PMC4666682; DOI: 10.1016/j.stem.2015.09.004;

Crane AM, Kramer P, Bui JH, Chung WJ, Li XS, Gonzalez-Garay ML, Hawkins F, Liao W, Mora D, Choi S, Wang J, Sun HC, Paschon DE, Guschin DY, Gregory PD, Kotton DN, Holmes MC, Sorscher EJ, Davis BR. Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells. Stem Cell Reports. 2015 Apr 14; 4(4):569-77.View Related Profiles.

Kotton, Darrell
Hawkins, Finn

PMID: 25772471; PMCID: PMC4400651; DOI: 10.1016/j.stemcr.2015.02.005;

Hawkins F, Kotton DN. Embryonic and induced pluripotent stem cells for lung regeneration. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S50-3.View Related Profiles.

Kotton, Darrell
Hawkins, Finn

PMID: 25830836; DOI: 10.1513/AnnalsATS.201410-457MG;

Longmire TA, Ikonomou L, Hawkins F, Christodoulou C, Cao Y, Jean JC, Kwok LW, Mou H, Rajagopal J, Shen SS, Dowton AA, Serra M, Weiss DJ, Green MD, Snoeck HW, Ramirez MI, Kotton DN. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell. 2012 Apr 6; 10(4):398-411.View Related Profiles.

Kotton, Darrell
Hawkins, Finn
Jean, Jyh-Chang
Ikonomou, Laertis
Ramirez, Maria
Cao, Yu-Xia

PMID: 22482505; PMCID: PMC3322392; DOI: 10.1016/j.stem.2012.01.019;

Hawkins F, Ebel N, Sorescu GP, McMahon L, Sprinz P, Klings ES. Keeping it in the family: three relatives with HbSC disease and simultaneous acute pulmonary emboli. Am J Hematol. 2012 Jan; 87(1):101-4.View Related Profiles.

Klings, Elizabeth
Hawkins, Finn
Sprinz, Phillipa

PMID: 21953788; DOI: 10.1002/ajh.22177;

Maldonado F, Cartin-Ceba R, Hawkins FJ, Ryu JH. Medical and surgical management of chylothorax and associated outcomes. Am J Med Sci. 2010 Apr; 339(4):314-8. PMID: 20124878; DOI: 10.1097/MAJ.0b013e3181cdcd6c;

Hawkins F, Murphy JG, Dunn WF. "Is my doctor impaired, or just sleep deprived?". Chest. 2009 Nov; 136(5):1194-7. PMID: 19892668; DOI: 10.1378/chest.09-1213;

Maldonado F, Hawkins FJ, Daniels CE, Doerr CH, Decker PA, Ryu JH. Pleural fluid characteristics of chylothorax. Mayo Clin Proc. 2009 Feb; 84(2):129-33. PMID: 19181646; PMCID: PMC2664583; DOI: 10.1016/S0025-6196(11)60820-3;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 24 publications over 9 distinct years, with a maximum of 6 publications in 2020