Andrew Berical | Profiles RNS

Andrew Berical, MD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Tufts University School of Medicine
MA, Boston University School of Medicine
BA, Bowdoin College

Websites

	Boston Medical Center Provider Profile
	LinkedIn
	ResearchGate
	Publications

ORCID : 0000-0002-0818-0259

Member
Boston University
Center for Regenerative Medicine

Member
Boston University
Pulmonary Center

BU Research

In-vivo human airway epithelial cells for CFTR gene therapy
06/01/2024 - 05/31/2026 (PI)
Emilys Entourage

Generation and Characterization of Lentiviral Transduced GFP+/Luciferase+ W1282X Induced Pluripotent Stem Cell Derived Airway Basal Cells
09/01/2025 - 11/30/2025 (Key Person / Mentor)
Cystic Fibrosis Foundation

A multi-omic and genetically-controlled assessment of iPSC-derived airway cells to advance therapies for CF
07/01/2022 - 06/30/2025 (PI)
Cystic Fibrosis Foundation

iPSC-Derived Small Airway Epithelial Cells as a Novel Model for Cystic Fibrosis
07/01/2020 - 06/30/2022 (PI)
Cystic Fibrosis Foundation

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Website Copy PMIDs To Clipboard

Wallman DJ, Homma ST, Finton M, Beermann M, Jacob A, Choksi SP, Pletcher SD, Xu H, Bawa PS, Reiter JF, Horani A, Brody SL, Berical A, Hawkins FJ. A stem cell-based platform for functional analysis of genetic variants in lung disease. bioRxiv. 2025 Jul 31.View Related Profiles.

Berical, Andrew
Jacob, Anjali
Wallman, Daniel
Hawkins, Finn
Homma, Sachiko

PMID: 40766356; PMCID: PMC12324314; DOI: 10.1101/2025.07.28.667211;

Berical AC, Kiyokawa H, Beermann ML, Wallman D, Cherfane G, Dunphy V, Pan J, Tilston-Lunel A, Varelas X, Horani A, Brody SL, Kotton DN, Hawkins FJ. Reply to Huang et al.: Sowing Tailored Seeds: Gene-edited Basal Cells for Precision Regulation of Airway Phenotypes. Am J Respir Crit Care Med. 2025 May; 211(5):884.View Related Profiles.

Berical, Andrew
Tilston-Lunel, Andrew
Wallman, Daniel
Kotton, Darrell
Hawkins, Finn
Cherfane, Gabrielle
Kiyokawa, Hirofumi
Varelas, Xaralabos

PMID: 39999444; PMCID: PMC12091012; DOI: 10.1164/rccm.202412-2535LE;

Brody SL, Pan J, Huang T, Xu J, Xu H, Koenitizer JR, Brennan SK, Nanjundappa R, Saba TG, Rumman N, Berical A, Hawkins FJ, Wang X, Zhang R, Mahjoub MR, Horani A, Dutcher SK. Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia. Sci Transl Med. 2025 Jan 29; 17(783):eadp5173.View Related Profiles.

Berical, Andrew
Hawkins, Finn

PMID: 39879322; PMCID: PMC12108131; DOI: 10.1126/scitranslmed.adp5173;

Berical AC, Kiyokawa H, Beermann ML, Wallman D, Cherfane G, Dunphy V, Pan J, Tilston-Lunel A, Varelas X, Horani A, Brody SL, Kotton DN, Hawkins FJ. Airway Disease Modeling with Gene-edited Human Basal Cell Transplantation. Am J Respir Crit Care Med. 2024 Nov 08; 211(1):131-4.View Related Profiles.

Berical, Andrew
Tilston-Lunel, Andrew
Wallman, Daniel
Kotton, Darrell
Hawkins, Finn
Cherfane, Gabrielle
Kiyokawa, Hirofumi
Varelas, Xaralabos

PMID: 39514838; PMCID: PMC11755362; DOI: 10.1164/rccm.202406-1110RL;

Koenitzer JR, Gupta DK, Twan WK, Xu H, Hadas N, Hawkins FJ, Beermann ML, Penny GM, Wamsley NT, Berical A, Major MB, Dutcher SK, Brody SL, Horani A. Transcriptional analysis of primary ciliary dyskinesia airway cells reveals a dedicated cilia glutathione pathway. JCI Insight. 2024 Jul 23; 9(17).View Related Profiles.

Berical, Andrew
Hawkins, Finn

PMID: 39042459; PMCID: PMC11385084; DOI: 10.1172/jci.insight.180198;

Brody SL, Pan J, Huang T, Xu J, Xu H, Koenitizer J, Brennan SK, Nanjundappa R, Saba TG, Berical A, Hawkins FJ, Wang X, Zhang R, Mahjoub MR, Horani A, Dutcher SK. Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy. bioRxiv. 2024 Mar 21.View Related Profiles.

Berical, Andrew
Hawkins, Finn

PMID: 38562900; PMCID: PMC10983967; DOI: 10.1101/2024.03.20.585965;

Ma L, Thapa BR, Le Suer JA, Tilston-Lünel A, Herriges MJ, Berical A, Beermann ML, Wang F, Bawa PS, Kohn A, Ysasi AB, Kiyokawa H, Matte TM, Randell SH, Varelas X, Hawkins FJ, Kotton DN. Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells. Cell Stem Cell. 2023 Sep 07; 30(9):1199-1216.e7.View Related Profiles.

Ma, Liang
Berical, Andrew
Kotton, Darrell
Hawkins, Finn
Kiyokawa, Hirofumi
Herriges, Michael
Matte, Taylor
Varelas, Xaralabos

PMID: 37625411; PMCID: PMC10528754; DOI: 10.1016/j.stem.2023.07.014;

Berical A, Lee RE, Lu J, Beermann ML, Le Suer JA, Mithal A, Thomas D, Ranallo N, Peasley M, Stuffer A, Bukis K, Seymour R, Harrington J, Coote K, Valley H, Hurley K, McNally P, Mostoslavsky G, Mahoney J, Randell SH, Hawkins FJ. A multimodal iPSC platform for cystic fibrosis drug testing. Nat Commun. 2022 Jul 29; 13(1):4270.View Related Profiles.

Berical, Andrew
Hawkins, Finn
Mostoslavsky, Gustavo

PMID: 35906215; PMCID: PMC9338271; DOI: 10.1038/s41467-022-31854-8;

Berical A, Beermann ML, Suzuki S, LeSuer J, Matte T, Davis B, Kotton D, Hawkins F. Generation of Airway Epithelial Cell Air-Liquid Interface Cultures from Human Pluripotent Stem Cells. J Vis Exp. 2022 Jun 14; (184).View Related Profiles.

Berical, Andrew
Kotton, Darrell
Hawkins, Finn
Matte, Taylor

PMID: 35781291

Garcia MA, Rampon GL, Doros G, Jia S, Jagan N, Gillmeyer K, Berical A, Hudspeth J, Ieong M, Modzelewski KL, Schechter-Perkins EM, Ross CS, Rucci JM, Simpson S, Walkey AJ, Bosch NA. Rationale and Design of the Awake Prone Position for Early Hypoxemia in COVID-19 Study Protocol: A Clinical Trial. Ann Am Thorac Soc. 2021 09; 18(9):1560-1566.View Related Profiles.

Walkey, Allan
Berical, Andrew
Ross, Craig
Schechter-Perkins, Elissa
Doros, Gheorghe
Hudspeth, James
Rucci, Justin
Gillmeyer, Kari
Modzelewski, Katherine
Garcia, Michael
Ieong, Michael
Bosch, Nicholas

PMID: 33647225; PMCID: PMC8489858; DOI: 10.1513/AnnalsATS.202009-1124SD;

Showing 10 of 29 results. Show More

Hawkins FJ, Suzuki S, Beermann ML, Barillà C, Wang R, Villacorta-Martin C, Berical A, Jean JC, Le Suer J, Matte T, Simone-Roach C, Tang Y, Schlaeger TM, Crane AM, Matthias N, Huang SXL, Randell SH, Wu J, Spence JR, Carraro G, Stripp BR, Rab A, Sorsher EJ, Horani A, Brody SL, Davis BR, Kotton DN. Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2021 01 07; 28(1):79-95.e8.View Related Profiles.

Berical, Andrew
Kotton, Darrell
Hawkins, Finn
Matte, Taylor

PMID: 33098807; PMCID: PMC7796997; DOI: 10.1016/j.stem.2020.09.017;

Mithal A, Capilla A, Heinze D, Berical A, Villacorta-Martin C, Vedaie M, Jacob A, Abo K, Szymaniak A, Peasley M, Stuffer A, Mahoney J, Kotton DN, Hawkins F, Mostoslavsky G. Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells. Nat Commun. 2020 01 10; 11(1):215.View Related Profiles.

Szymaniak, Aleksander
Berical, Andrew
Jacob, Anjali
Heinze, Dar
Kotton, Darrell
Hawkins, Finn
Mostoslavsky, Gustavo

PMID: 31924806; PMCID: PMC6954238; DOI: 10.1038/s41467-019-13916-6;

Berical A, Lee RE, Randell SH, Hawkins F. Challenges Facing Airway Epithelial Cell-Based Therapy for Cystic Fibrosis. Front Pharmacol. 2019; 10:74.View Related Profiles.

Berical, Andrew
Hawkins, Finn

PMID: 30800069; PMCID: PMC6376457; DOI: 10.3389/fphar.2019.00074;

Zhang C, Ramsey C, Berical A, Yu L, Leng L, McGinnis KA, Song Y, Michael H, McCormack MC, Allore H, Morris A, Crothers K, Bucala R, Lee PJ, Sauler M. A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity. Am J Physiol Lung Cell Mol Physiol. 2019 02 01; 316(2):L400-L405. PMID: 30520689; PMCID: PMC6397351; DOI: 10.1152/ajplung.00439.2018;

Abston ED, Hon SM, Berical A. Pulmonology in Pregnancy. Am J Respir Crit Care Med. 2018 01 01; 197(1):127-129. PMID: 29155600

Berical AC, Harris D, Dela Cruz CS, Possick JD. Pneumococcal Vaccination Strategies. An Update and Perspective. Ann Am Thorac Soc. 2016 06; 13(6):933-44. PMID: 27088424; PMCID: PMC5461988; DOI: 10.1513/AnnalsATS.201511-778FR;

Ansari IU, Allen T, Berical A, Stock PG, Barin B, Striker R. Phenotypic analysis of NS5A variant from liver transplant patient with increased cyclosporine susceptibility. Virology. 2013 Feb 20; 436(2):268-73. PMID: 23290631; PMCID: PMC3761804; DOI: 10.1016/j.virol.2012.11.018;

Newman RM, Kuntzen T, Weiner B, Berical A, Charlebois P, Kuiken C, Murphy DG, Simmonds P, Bennett P, Lennon NJ, Birren BW, Zody MC, Allen TM, Henn MR. Whole genome pyrosequencing of rare hepatitis C virus genotypes enhances subtype classification and identification of naturally occurring drug resistance variants. J Infect Dis. 2013 Jul; 208(1):17-31. PMID: 23136221; PMCID: PMC3666132; DOI: 10.1093/infdis/jis679;

Henn MR, Boutwell CL, Charlebois P, Lennon NJ, Power KA, Macalalad AR, Berlin AM, Malboeuf CM, Ryan EM, Gnerre S, Zody MC, Erlich RL, Green LM, Berical A, Wang Y, Casali M, Streeck H, Bloom AK, Dudek T, Tully D, Newman R, Axten KL, Gladden AD, Battis L, Kemper M, Zeng Q, Shea TP, Gujja S, Zedlack C, Gasser O, Brander C, Hess C, Günthard HF, Brumme ZL, Brumme CJ, Bazner S, Rychert J, Tinsley JP, Mayer KH, Rosenberg E, Pereyra F, Levin JZ, Young SK, Jessen H, Altfeld M, Birren BW, Walker BD, Allen TM. Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection. PLoS Pathog. 2012; 8(3):e1002529. PMID: 22412369; PMCID: PMC3297584; DOI: 10.1371/journal.ppat.1002529;

Oniangue-Ndza C, Kuntzen T, Kemper M, Berical A, Wang YE, Neumann-Haefelin C, Foote PK, Hills-Evans K, Reyor LL, Kane K, Gladden AD, Bloom AK, Power KA, Thimme R, Lauer GM, Henn MR, Kim AY, Allen TM. Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymerase. J Virol. 2011 Nov; 85(22):11883-90. PMID: 21880756; PMCID: PMC3209273; DOI: 10.1128/JVI.00779-11;

Peng LF, Schaefer EA, Maloof N, Skaff A, Berical A, Belon CA, Heck JA, Lin W, Frick DN, Allen TM, Miziorko HM, Schreiber SL, Chung RT. Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase. J Infect Dis. 2011 Aug 15; 204(4):609-16. PMID: 21791663; PMCID: PMC3144167; DOI: 10.1093/infdis/jir303;

Kim AY, Kuntzen T, Timm J, Nolan BE, Baca MA, Reyor LL, Berical AC, Feller AJ, Johnson KL, Schulze zur Wiesch J, Robbins GK, Chung RT, Walker BD, Carrington M, Allen TM, Lauer GM. Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes. Gastroenterology. 2011 Feb; 140(2):686-696.e1. PMID: 20875418; PMCID: PMC3021586; DOI: 10.1053/j.gastro.2010.09.042;

Kasprowicz V, Kang YH, Lucas M, Schulze zur Wiesch J, Kuntzen T, Fleming V, Nolan BE, Longworth S, Berical A, Bengsch B, Thimme R, Lewis-Ximenez L, Allen TM, Kim AY, Klenerman P, Lauer GM. Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution. J Virol. 2010 Feb; 84(3):1656-63. PMID: 19906915; PMCID: PMC2812309; DOI: 10.1128/JVI.01499-09;

Kim AY, Timm J, Nolan BE, Reyor LL, Kane K, Berical AC, Zachary KC, Lauer GM, Kuntzen T, Allen TM. Temporal dynamics of a predominant protease inhibitor-resistance mutation in a treatment-naive, hepatitis C virus-infected individual. J Infect Dis. 2009 Mar 01; 199(5):737-41. PMID: 19199553; PMCID: PMC2653266; DOI: 10.1086/596657;

Kuntzen T, Timm J, Berical A, Lennon N, Berlin AM, Young SK, Lee B, Heckerman D, Carlson J, Reyor LL, Kleyman M, McMahon CM, Birch C, Schulze Zur Wiesch J, Ledlie T, Koehrsen M, Kodira C, Roberts AD, Lauer GM, Rosen HR, Bihl F, Cerny A, Spengler U, Liu Z, Kim AY, Xing Y, Schneidewind A, Madey MA, Fleckenstein JF, Park VM, Galagan JE, Nusbaum C, Walker BD, Lake-Bakaar GV, Daar ES, Jacobson IM, Gomperts ED, Edlin BR, Donfield SM, Chung RT, Talal AH, Marion T, Birren BW, Henn MR, Allen TM. Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients. Hepatology. 2008 Dec; 48(6):1769-78.View Related Profiles.

Berical, Andrew
Galagan, James

PMID: 19026009; PMCID: PMC2645896; DOI: 10.1002/hep.22549;

Kuntzen T, Berical A, Ndjomou J, Bennett P, Schneidewind A, Lennon N, Birren BW, Kuiken C, Henn MR, Simmonds P, Allen TM. A set of reference sequences for the hepatitis C genotypes 4d, 4f, and 4k covering the full open reading frame. J Med Virol. 2008 Aug; 80(8):1370-8. PMID: 18551618; PMCID: PMC2818806; DOI: 10.1002/jmv.21240;

Kasprowicz V, Schulze Zur Wiesch J, Kuntzen T, Nolan BE, Longworth S, Berical A, Blum J, McMahon C, Reyor LL, Elias N, Kwok WW, McGovern BG, Freeman G, Chung RT, Klenerman P, Lewis-Ximenez L, Walker BD, Allen TM, Kim AY, Lauer GM. High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. J Virol. 2008 Mar; 82(6):3154-60. PMID: 18160439; PMCID: PMC2258997; DOI: 10.1128/JVI.02474-07;

Kuntzen T, Timm J, Berical A, Lewis-Ximenez LL, Jones A, Nolan B, Schulze zur Wiesch J, Li B, Schneidewind A, Kim AY, Chung RT, Lauer GM, Allen TM. Viral sequence evolution in acute hepatitis C virus infection. J Virol. 2007 Nov; 81(21):11658-68. PMID: 17699568; PMCID: PMC2168804; DOI: 10.1128/JVI.00995-07;

Schulze Zur Wiesch J, Lauer GM, Timm J, Kuntzen T, Neukamm M, Berical A, Jones AM, Nolan BE, Longworth SA, Kasprowicz V, McMahon C, Wurcel A, Lohse AW, Lewis-Ximenez LL, Chung RT, Kim AY, Allen TM, Walker BD. Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infection. Blood. 2007 Sep 01; 110(5):1559-69.View Related Profiles.

Wurcel, Alysse
Berical, Andrew

PMID: 17475911; PMCID: PMC1975840; DOI: 10.1182/blood-2007-01-069583;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 29 publications over 16 distinct years, with a maximum of 3 publications in 2007 and 2024 and 2025

Bar chart showing 29 publications over 16 distinct years, with a maximum of 3 publications in 2007 and 2024 and 2025

Year	Publications
2007	3
2008	2
2009	2
2010	1
2011	2
2012	2
2013	1
2016	1
2018	2
2019	1
2020	2
2021	1
2022	2
2023	1
2024	3
2025	3

Media Mentions

2024 Ignition Awards Aim to Bring BU Science and Tech to Market

The Brink 8/22/2024

Novel model system to identify new treatments for CF patients who continue to struggle without therapies

AZO Life Sciences 8/3/2022

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Lung Development
Stem Cell Biology
Cystic Fibrosis
Pulmonary Medicine
Critical Care Medicine
Genetic Lung Disease

Contact for Mentoring:

72 E. Concord Street
Boston MA 02118
Google Map

617.358.2800

Download vCard

Berical's Networks

Click the "See All" links for more information and interactive visualizations

Concepts

See all (156) concept(s)

Media Mentions

Co-Authors

See all (24) people

Similar People

See all (60) people

Same Department

Search Department