David Richard Pimentel, MD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Cardiovascular Medicine

MD, University of Maryland School of Medicine
BA, University of Maryland



Expertise includes: Oxidative modification; Exosomal communication.

Member
Boston University
Whitaker Cardiovascular Institute


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research




Mechanistic underpinnings of increased adipose tissue in HFpEF
07/01/2019 - 06/30/2024 (Key Person)
PI: Flora Sam, MD
NIH/National Heart, Lung, and Blood Institute
5R01HL145985-04


Ventrizular Remodeling from H202 in Mechanical Overload
09/30/2005 - 08/31/2010 (PI)
NIH-NHLBI
5 K08 HL071563-04

Mechanisms of Hydrogen peroxide regulation of MYO
07/01/2003 - 06/30/2008 (PI)
American Heart Assoc

Mechanism of Hydrogen Peroxide induced ventrical
07/01/2002 - 06/30/2004 (PI)
American Heart Assoc


Title


Yr Title Project-Sub Proj Pubs
2009 Ventricular Remodeling from H202 in Mechanical Overload 5K08HL071563-05 7
2008 Ventricular Remodeling from H202 in Mechanical Overload 5K08HL071563-04 7
2007 Ventricular Remodeling from H202 in Mechanical Overload 5K08HL071563-03 7
2006 Ventricular Remodeling from H202 in Mechanical Overload 5K08HL071563-02 7
2005 Ventricular Remodeling from H202 in Mechanical Overload 1K08HL071563-01A1 7

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Croteau D, Baka T, Young S, He H, Chambers JM, Qin F, Panagia M, Pimentel DR, Balschi JA, Colucci WS, Luptak I. SGLT2 inhibitor ertugliflozin decreases elevated intracellular sodium, and improves energetics and contractile function in diabetic cardiomyopathy. Biomed Pharmacother. 2023 Apr; 160:114310.View Related Profiles. PMID: 36731341; PMCID: PMC9992115; DOI: 10.1016/j.biopha.2023.114310;
     
  2. Mustafa Rizvi SH, Shao D, Tsukahara Y, Pimentel DR, Weisbrod RM, Hamburg NM, McComb ME, Matsui R, Bachschmid MM. Oxidized GAPDH transfers S-glutathionylation to a nuclear protein Sirtuin-1 leading to apoptosis. Free Radic Biol Med. 2021 10; 174:73-83.View Related Profiles. PMID: 34332079; PMCID: PMC8432375; DOI: 10.1016/j.freeradbiomed.2021.07.037;
     
  3. Croteau D, Luptak I, Chambers JM, Hobai I, Panagia M, Pimentel DR, Siwik DA, Qin F, Colucci WS. Effects of Sodium-Glucose Linked Transporter 2 Inhibition With Ertugliflozin on Mitochondrial Function, Energetics, and Metabolic Gene Expression in the Presence and Absence of Diabetes Mellitus in Mice. J Am Heart Assoc. 2021 07 06; 10(13):e019995.View Related Profiles. PMID: 34169737; PMCID: PMC8403324; DOI: 10.1161/JAHA.120.019995;
     
  4. Goodman JB, Qin F, Morgan RJ, Chambers JM, Croteau D, Siwik DA, Hobai I, Panagia M, Luptak I, Bachschmid M, Tong X, Pimentel DR, Cohen RA, Colucci WS. Redox-Resistant SERCA [Sarco(endo)plasmic Reticulum Calcium ATPase] Attenuates Oxidant-Stimulated Mitochondrial Calcium and Apoptosis in Cardiac Myocytes and Pressure Overload-Induced Myocardial Failure in Mice. Circulation. 2020 12 22; 142(25):2459-2469.View Related Profiles. PMID: 33076678; PMCID: PMC7752816; DOI: 10.1161/CIRCULATIONAHA.120.048183;
     
  5. Burns M, Rizvi SHM, Tsukahara Y, Pimentel DR, Luptak I, Hamburg NM, Matsui R, Bachschmid MM. Role of Glutaredoxin-1 and Glutathionylation in Cardiovascular Diseases. Int J Mol Sci. 2020 Sep 16; 21(18).View Related Profiles. PMID: 32948023; PMCID: PMC7555996; DOI: 10.3390/ijms21186803;
     
  6. Croteau D, Qin F, Chambers JM, Kallick E, Luptak I, Panagia M, Pimentel DR, Siwik DA, Colucci WS. Differential Effects of Sacubitril/Valsartan on Diastolic Function in Mice With Obesity-Related Metabolic Heart Disease. JACC Basic Transl Sci. 2020 Sep; 5(9):916-927.View Related Profiles. PMID: 33015414; PMCID: PMC7524781; DOI: 10.1016/j.jacbts.2020.07.006;
     
  7. Panagia M, Yang J, Gale E, Wang H, Luptak I, Chen HH, Patel D, Croteau D, Pimentel DR, Bachschmid MM, Colucci WS, Ran C, Sosnovik DE. A novel tracer for in vivo optical imaging of fatty acid metabolism in the heart and brown adipose tissue. Sci Rep. 2020 07 08; 10(1):11209.View Related Profiles. PMID: 32641756; PMCID: PMC7343860; DOI: 10.1038/s41598-020-68065-4;
     
  8. Igwebuike C, Yaglom J, Huiting L, Feng H, Campbell JD, Wang Z, Havasi A, Pimentel D, Sherman MY, Borkan SC. Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity. Cell Death Dis. 2020 04 03; 11(4):217.View Related Profiles. PMID: 32245975; PMCID: PMC7125232; DOI: 10.1038/s41419-020-2382-7;
     
  9. Panagia M, He H, Baka T, Pimentel DR, Croteau D, Bachschmid MM, Balschi JA, Colucci WS, Luptak I. Increasing mitochondrial ATP synthesis with butyrate normalizes ADP and contractile function in metabolic heart disease. NMR Biomed. 2020 05; 33(5):e4258.View Related Profiles. PMID: 32066202; PMCID: PMC7165026; DOI: 10.1002/nbm.4258;
     
  10. Matsui R, Ferran B, Oh A, Croteau D, Shao D, Han J, Pimentel DR, Bachschmid MM. Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation. Antioxid Redox Signal. 2020 04 01; 32(10):677-700.View Related Profiles. PMID: 31813265; PMCID: PMC7047114; DOI: 10.1089/ars.2019.7963;
     
Showing 10 of 68 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 68 publications over 21 distinct years, with a maximum of 7 publications in 2004 and 2020

YearPublications
19981
20011
20022
20034
20047
20055
20064
20074
20084
20095
20102
20115
20123
20132
20144
20161
20181
20193
20207
20212
20231

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

exosomes
glutathiolation
heart failure
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650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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