Flora Sam | Profiles RNS

Flora Sam, MD

Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Cardiovascular Medicine

MD, University of the Witwatersrand

Websites

	Sam Lab
	LinkedIn

ORCID : 0000-0001-8442-9362

Dr. Sam is the present Director, ad interim, of the Whitaker Cardiovascular Institute. She is an advanced heart failure clinical cardiologist and a physician-scientist. She is a translational researcher and the PI of her NIH funded lab. She is an expert in cardiac myocyte biology and in mechanisms of myocardial remodeling in cardiomyopathy, both in humans and animal models. She is a recognized expert in "heart failure with preserved ejection fraction" (HFpEF) /diastolic heart failure and "heart failure with reduced ejection fraction" (HFrEF)/systolic heart failure and cardiomyopathies.

The Sam lab is focused on three major areas of investigation:
1) Pro-inflammatory and pro-fibrotic mechanisms that mediate cardiac remodeling in heart failure, cardiac hypertrophy and hypertension.
2) Investigating the relationship between matrix markers and heart failure in humans with cardiac amyloid and scleroderma.
3) Investigating cross talk between adipocyte-derived factors, myokines and cardiokines in heart failure.

Member
Boston University
Whitaker Cardiovascular Institute

Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Mechanistic underpinnings of increased adipose tissue in HFpEF
07/01/2019 - 06/30/2025 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL145985-04

Protocol #C1973-204 - A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 2 Study Evaluating the Safety and Efficacy of Different Doses of IW-1973 over 12 Weeks in Patients with Heart
04/18/2018 - 04/17/2022 (PI)
Ironwood Pharmaceuticals, Inc.

Protocol # EFC15156:A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Effects of SOtagLiflozin on Clinical Outcomes in HemOdynamIcally STable Patients
11/12/2018 - 11/12/2021 (PI)
Sanofi-Aventis, U.S., LLC

Dual ETA/ETB antagonist macitentan inhibits the progression from left ventricular (LV) hypertrophy to heart failure in a murine model of diastolic heart failure
10/15/2014 - 10/14/2019 (PI)
Actelion Pharmaceuticals, Ltd.

Role of Aldosterone and Adiponectin in Inter-Tissue Communication in Diastolic Heart Failure
06/01/2016 - 05/31/2019 (PI)
NIH/National Heart, Lung, and Blood Institute
4R01HL117153-04

Role of Aldosterone and Adiponectin in Inter-Tissue Communication in Diastolic Heart Failure
09/01/2013 - 05/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL117153-03

Follistatin-Like 1 and the Cardiac Secretome in Human Heart Failure
04/15/2010 - 03/31/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
5R21HL102631-02

The REVIVE Study
06/01/2002 - 07/31/2003 (PI)
Abbott Laboratories

A Placebo Controlled Trial of Bidil Added to Standard Therapy in African-American Patients with Heart Failure
11/01/2001 - 10/30/2002 (PI)
NitroMed Inc

Role of Aldosterone in Cardiac Remodeling
06/01/2005 - 04/30/2010 (PI)
NIH-NHLBI
5 R01 HL079099-03 (A)

Fixed-does isosorbide dinitrate and hydralazine in a mouse left ventricular pressure overload model
02/01/2006 - 01/31/2007 (PI)
Nitromed

Oxidative Stress/AE in Heart Failure
08/01/2000 - 07/31/2005 (PI)
NIH-NHLBI
5 K23 HL004423-05

Aldosterone in Transition from Hypetrophy
07/01/2002 - 06/30/2005 (PI)
American Heart Assoc

Title

Yr	Title	Project-Sub Proj	Pubs
2022	Mechanistic underpinnings of increased adipose tissue in HFpEF	5R01HL145985-04
2021	Mechanistic underpinnings of increased adipose tissue in HFpEF	5R01HL145985-03	1
2020	Mechanistic underpinnings of increased adipose tissue in HFpEF	5R01HL145985-02	1
2019	Mechanistic underpinnings of increased adipose tissue in HFpEF	1R01HL145985-01A1	1
2016	Role of Aldosterone and Adiponectin in Inter-Tissue Communication in Diastolic He	4R01HL117153-04	9
2015	Role of Aldosterone and Adiponectin in Inter-Tissue Communication in Diastolic He	5R01HL117153-03	9
2014	Role of Aldosterone and Adiponectin in Inter-Tissue Communication in Diastolic He	5R01HL117153-02	9
2013	Role of Aldosterone and Adiponectin in Inter-Tissue Communication in Diastolic He	1R01HL117153-01A1	9
2011	Follistatin-like 1 and the cardiac secretome in human heart failure	5R21HL102631-02	8
2011	Novel Insights into the Pathogenesis of Light Chain Cardiac Amyloidosis	5R21HL095891-02	16

Showing 10 of 28 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Yu Z, Chen Y, Miranda O, Qi M, Zhang M, Feng N, Ryan TP, Schloot NC, Chen Y, Sam F, Wang L. Association of Long-Term Body Mass Index Variability With the Development of Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction Across Patterns of Weight Change. J Am Heart Assoc. 2025 Sep 16; 14(18):e039976. PMID: 40932106; PMCID: PMC12554408; DOI: 10.1161/JAHA.124.039976;

Borlaug BA, Testani JM, Petrie MC, Wang Z, Cunningham J, Adams KF, Amir O, Belohlávek J, Bocchi E, Freitas A, Hominal M, Kadokami T, Merkely B, Miller CA, Nuñez J, Verma S, Yilmaz MB, Oru E, Sam F. Effects of volenrelaxin in worsening heart failure with preserved ejection fraction: a phase 2 randomized trial. Nat Med. 2025 Nov; 31(11):3853-3861. PMID: 40887551; PMCID: PMC12618225; DOI: 10.1038/s41591-025-03939-6;

Saw EL, Werner LD, Cooper HL, Pimental DR, Zamani P, Chirinos JA, Valero-Muñoz M, Sam F. Musclin Counteracts Skeletal Muscle Dysfunction and Exercise Intolerance in Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2025 Jun; 18(6):e012350.View Related Profiles.

Saw, Eng
Sam, Flora
Werner, Louis

PMID: 40358602; PMCID: PMC12165570; DOI: 10.1161/CIRCHEARTFAILURE.124.012350;

Valero-Muñoz M, Saw EL, Cooper H, Pimentel DR, Sam F. White Adipose Tissue in Obesity-Associated HFpEF: Insights From Mice and Humans. JACC Basic Transl Sci. 2025 Aug; 10(8):101262.View Related Profiles.

Pimentel, David
Saw, Eng
Sam, Flora

PMID: 40338771; PMCID: PMC12399134; DOI: 10.1016/j.jacbts.2025.02.021;

Han S, Yu S, Shi M, Harada M, Ge J, Lin J, Prehn C, Petrera A, Li Y, Sam F, Matullo G, Adamski J, Suhre K, Gieger C, Hauck SM, Herder C, Roden M, Casale FP, Cai N, Peters A, Wang-Sattler R. LEOPARD: missing view completion for multi-timepoint omics data via representation disentanglement and temporal knowledge transfer. Nat Commun. 2025 Apr 06; 16(1):3278. PMID: 40188173; PMCID: PMC11972361; DOI: 10.1038/s41467-025-58314-3;

Tham LS, Heerspink HJL, Wang X, Verdino P, Saifan CG, Benson EA, Goldsmith P, Wang Z, Testani JM, Haupt A, Sam F, Cherney DZI. Volenrelaxin (LY3540378) increases renal plasma flow: a randomized Phase 1 trial. Nephrol Dial Transplant. 2024 Dec 20; 40(1):109-122. PMID: 38782726; PMCID: PMC11659974; DOI: 10.1093/ndt/gfae112;

Valero-Muñoz M, Sam F. Endothelin-1: Is it Time to "Biomark" the Cardiac-Tumor-Treatment Nexus in Breast Cancer? JACC CardioOncol. 2023 Oct; 5(5):701-703. PMID: 37969651; PMCID: PMC10635882; DOI: 10.1016/j.jaccao.2023.05.007;

Ferdinand KC, Dunn J, Nicolay C, Sam F, Blue EK, Wang H. Weight-dependent and weight-independent effects of dulaglutide on blood pressure in patients with type 2 diabetes. Cardiovasc Diabetol. 2023 Mar 09; 22(1):49. PMID: 36894938; PMCID: PMC9999488; DOI: 10.1186/s12933-023-01775-x;

El-Adili F, Lui JK, Najem M, Farina G, Trojanowska M, Sam F, Bujor AM. Correction: Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications. Arthritis Res Ther. 2023 Jan 23; 25(1):11.View Related Profiles.

Bujor, Andreea
Sam, Flora
Lui, Justin
Trojanowska, Maria

PMID: 36691037; PMCID: PMC9869504; DOI: 10.1186/s13075-023-02993-0;

Saw EL, Werner LD, Zamani P, Chirinos JA, Valero-Muñoz M, Sam F. Skeletal muscle phenotypic switching in heart failure with preserved ejection fraction. Front Cardiovasc Med. 2022; 9:1016452.View Related Profiles.

Saw, Eng
Sam, Flora
Werner, Louis

PMID: 36531739; PMCID: PMC9753550; DOI: 10.3389/fcvm.2022.1016452;

Showing 10 of 90 results. Show More

El-Adili F, Lui JK, Najem M, Farina G, Trojanowska M, Sam F, Bujor AM. Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications. Arthritis Res Ther. 2022 Nov 11; 24(1):251.View Related Profiles.

Bujor, Andreea
Sam, Flora
Lui, Justin
Trojanowska, Maria

PMID: 36369212; PMCID: PMC9650849; DOI: 10.1186/s13075-022-02943-2;

Valero-Muñoz M, Saw EL, Hekman RM, Blum BC, Hourani Z, Granzier H, Emili A, Sam F. Proteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF). Front Cardiovasc Med. 2022; 9:966968.View Related Profiles.

Blum, Benjamin
Saw, Eng
Sam, Flora

PMID: 36093146; PMCID: PMC9452734; DOI: 10.3389/fcvm.2022.966968;

Roh J, Hill JA, Singh A, Valero-Muñoz M, Sam F. Heart Failure With Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models. Circ Res. 2022 Jun 10; 130(12):1906-1925. PMID: 35679364; PMCID: PMC10035274; DOI: 10.1161/CIRCRESAHA.122.320257;

Valero-Muñoz M, Sam F. A misdirected conundrum in translational HFpEF research. J Mol Cell Cardiol. 2022 Jul; 168:1-2. PMID: 35405105

Pandey A, Shah SJ, Butler J, Kellogg DL, Lewis GD, Forman DE, Mentz RJ, Borlaug BA, Simon MA, Chirinos JA, Fielding RA, Volpi E, Molina AJA, Haykowsky MJ, Sam F, Goodpaster BH, Bertoni AG, Justice JN, White JP, Ding J, Hummel SL, LeBrasseur NK, Taffet GE, Pipinos II, Kitzman D. Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 09 14; 78(11):1166-1187. PMID: 34503685; PMCID: PMC8525886; DOI: 10.1016/j.jacc.2021.07.014;

Valero-Muñoz M, Oh A, Faudoa E, Bretón-Romero R, El Adili F, Bujor A, Sam F. Endothelial-Mesenchymal Transition in Heart Failure With a Preserved Ejection Fraction: Insights Into the Cardiorenal Syndrome. Circ Heart Fail. 2021 09; 14(9):e008372.View Related Profiles.

Oh, Albin
Bujor, Andreea
El Adili, Fatima
Sam, Flora

PMID: 34407636; PMCID: PMC8575120; DOI: 10.1161/CIRCHEARTFAILURE.121.008372;

Saw EL, Ramachandran S, Valero-Muñoz M, Sam F. Skeletal muscle (dys)function in heart failure with preserved ejection fraction. Curr Opin Cardiol. 2021 03 01; 36(2):219-226.View Related Profiles.

Saw, Eng
Sam, Flora
Valero Munoz, Maria
Ramachandran, Swetha

PMID: 33394707; PMCID: PMC7895420; DOI: 10.1097/HCO.0000000000000824;

Valero-Muñoz M, Sam F. Reply to letter by Ye et al., blocking lncRNA H19/miR-194-5p/SIRT1 axis in cardiac myocyte is responsible for doxycycline inhibiting autophagy. Int J Cardiol. 2021 05 15; 331:213.View Related Profiles.

Sam, Flora
Valero Munoz, Maria

PMID: 33515616

Valero-Muñoz M, Sam F. Reply to letter by Hou et al., Doxycycline ameliorates autophagy by inhibiting p38 MAPK in cardiac myocytes. Int J Cardiol. 2021 05 15; 331:212.View Related Profiles.

Sam, Flora
Valero Munoz, Maria

PMID: 33515614

Valero-Muñoz M, Wilson RM, Bretón-Romero R, Croteau D, Seldin DC, Sam F. Doxycycline decreases amyloidogenic light chain-induced autophagy in isolated primary cardiac myocytes. Int J Cardiol. 2020 12 15; 321:133-136.View Related Profiles.

Sam, Flora
Valero Munoz, Maria

PMID: 32682005; PMCID: PMC9020138; DOI: 10.1016/j.ijcard.2020.07.016;

Shah SJ, Borlaug BA, Kitzman DW, McCulloch AD, Blaxall BC, Agarwal R, Chirinos JA, Collins S, Deo RC, Gladwin MT, Granzier H, Hummel SL, Kass DA, Redfield MM, Sam F, Wang TJ, Desvigne-Nickens P, Adhikari BB. Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary. Circulation. 2020 03 24; 141(12):1001-1026. PMID: 32202936; PMCID: PMC7101072; DOI: 10.1161/CIRCULATIONAHA.119.041886;

Butt SA, Jeppesen JL, Torp-Pedersen C, Sam F, Gislason GH, Jacobsen S, Andersson C. Cardiovascular Manifestations of Systemic Sclerosis: A Danish Nationwide Cohort Study. J Am Heart Assoc. 2019 09 03; 8(17):e013405. PMID: 31446827; PMCID: PMC6755829; DOI: 10.1161/JAHA.119.013405;

Oh A, Okazaki R, Sam F, Valero-Muñoz M. Heart Failure With Preserved Ejection Fraction and Adipose Tissue: A Story of Two Tales. Front Cardiovasc Med. 2019; 6:110.View Related Profiles.

Oh, Albin
Sam, Flora
Valero Munoz, Maria

PMID: 31428620; PMCID: PMC6687767; DOI: 10.3389/fcvm.2019.00110;

Tahir UA, Doros G, Kim JS, Connors LH, Seldin DC, Sam F. Predictors of Mortality in Light Chain Cardiac Amyloidosis with Heart Failure. Sci Rep. 2019 06 12; 9(1):8552.View Related Profiles.

Sam, Flora
Doros, Gheorghe
Connors, Lawreen

PMID: 31189919; PMCID: PMC6561903; DOI: 10.1038/s41598-019-44912-x;

Yunis A, Doros G, Luptak I, Connors LH, Sam F. Use of Ventilatory Efficiency Slope as a Marker for Increased Mortality in Wild-Type Transthyretin Cardiac Amyloidosis. Am J Cardiol. 2019 07 01; 124(1):122-130.View Related Profiles.

Sam, Flora
Doros, Gheorghe
Luptak, Ivan
Connors, Lawreen

PMID: 31053293; PMCID: PMC6556126; DOI: 10.1016/j.amjcard.2019.03.035;

Valero-Muñoz M, Sam F. Reply: Diet-Induced Obesity HFpEF Murine Models. JACC Basic Transl Sci. 2018 Feb; 3(1):158-159.View Related Profiles.

Sam, Flora
Valero Munoz, Maria

PMID: 30062201; PMCID: PMC6059000; DOI: 10.1016/j.jacbts.2018.01.006;

Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M. Cardiac macrophages promote diastolic dysfunction. J Exp Med. 2018 02 05; 215(2):423-440.View Related Profiles.

Sam, Flora
Valero Munoz, Maria

PMID: 29339450; PMCID: PMC5789416; DOI: 10.1084/jem.20171274;

Pimental DR, Sam F. Is Protein Kinase C Inhibition the Tip of the Iceberg in New Therapeutics for Acutely Decompensated Heart Failure? JACC Basic Transl Sci. 2017 Dec; 2(6):684-687. PMID: 30069551; PMCID: PMC6066669; DOI: 10.1016/j.jacbts.2017.11.005;

Valero-Muñoz M, Backman W, Sam F. Murine Models of Heart Failure with Preserved Ejection Fraction: a "Fishing Expedition". JACC Basic Transl Sci. 2017 Dec; 2(6):770-789.View Related Profiles.

Sam, Flora
Valero Munoz, Maria

PMID: 29333506; PMCID: PMC5764178; DOI: 10.1016/j.jacbts.2017.07.013;

Valero-Munoz M, Li S, Wilson RM, Boldbaatar B, Iglarz M, Sam F. Dual Endothelin-A/Endothelin-B Receptor Blockade and Cardiac Remodeling in Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2016 Nov; 9(11).View Related Profiles.

Boldbaatar, Batbold
Sam, Flora
Valero Munoz, Maria

PMID: 27810862; PMCID: PMC5584628; DOI: 10.1161/CIRCHEARTFAILURE.116.003381;

Tanaka K, Valero-Muñoz M, Wilson RM, Essick EE, Fowler CT, Nakamura K, van den Hoff M, Ouchi N, Sam F. Follistatin like 1 Regulates Hypertrophy in Heart Failure with Preserved Ejection Fraction. JACC Basic Transl Sci. 2016 Jun; 1(4):207-221.View Related Profiles.

Sam, Flora
Nakamura, Kazuto
Tanaka, Komei
Valero Munoz, Maria

PMID: 27430031; PMCID: PMC4944656; DOI: 10.1016/j.jacbts.2016.04.002;

Valero-Muñoz M, Li S, Wilson RM, Hulsmans M, Aprahamian T, Fuster JJ, Nahrendorf M, Scherer PE, Sam F. Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue. Circ Heart Fail. 2016 Jan; 9(1):e002724.View Related Profiles.

Sam, Flora
Fuster Ortuno, Jose
Valero Munoz, Maria
Aprahamian, Tamar

PMID: 26721917; PMCID: PMC4698901; DOI: 10.1161/CIRCHEARTFAILURE.115.002724;

Connors LH, Sam F, Skinner M, Salinaro F, Sun F, Ruberg FL, Berk JL, Seldin DC. Heart Failure Resulting From Age-Related Cardiac Amyloid Disease Associated With Wild-Type Transthyretin: A Prospective, Observational Cohort Study. Circulation. 2016 Jan 19; 133(3):282-90.View Related Profiles.

Sun, Fangui
Sam, Flora
Ruberg, Frederick
Berk, John
Connors, Lawreen
Skinner, Martha

PMID: 26660282; PMCID: PMC4718760; DOI: 10.1161/CIRCULATIONAHA.115.018852;

Hulsmans M, Sam F, Nahrendorf M. Monocyte and macrophage contributions to cardiac remodeling. J Mol Cell Cardiol. 2016 Apr; 93:149-55. PMID: 26593722; PMCID: PMC4846552; DOI: 10.1016/j.yjmcc.2015.11.015;

Lindsey ML, Mayr M, Gomes AV, Delles C, Arrell DK, Murphy AM, Lange RA, Costello CE, Jin YF, Laskowitz DT, Sam F, Terzic A, Van Eyk J, Srinivas PR. Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. Circulation. 2015 Sep 1; 132(9):852-72.View Related Profiles.

Costello, Catherine
Sam, Flora

PMID: 26195497; DOI: 10.1161/CIR.0000000000000226;

Tahir U, Sam F. Withdrawal of heart failure medications in peripartum cardiomyopathy after myocardial recovery. Int J Cardiol. 2015 Jul 1; 190:212-3.View Related Profiles.

Sam, Flora
Tahir, Usman

PMID: 25920029; DOI: 10.1016/j.ijcard.2015.04.169;

Tahir U, Doros G, Sam F. Delayed myocardial recovery in peripartum cardiomyopathy. Int J Cardiol. 2015 Apr 1; 184:310-2.View Related Profiles.

Sam, Flora
Doros, Gheorghe
Tahir, Usman

PMID: 25731846; DOI: 10.1016/j.ijcard.2015.02.064;

Brogan A, Ding Y, Pimentel DR, Sam F. Non-invasive imaging for cardiac amyloidosis - delaying the obvious? Int J Cardiol. 2014 Dec 15; 177(2):e87-9.View Related Profiles.

Pimentel, David
Sam, Flora

PMID: 25456697

Tanaka K, Wilson RM, Essick EE, Duffen JL, Scherer PE, Ouchi N, Sam F. Effects of adiponectin on calcium-handling proteins in heart failure with preserved ejection fraction. Circ Heart Fail. 2014 Nov; 7(6):976-85.View Related Profiles.

Sam, Flora
Duffen, Jennifer
Tanaka, Komei

PMID: 25149095; PMCID: PMC4241144; DOI: 10.1161/CIRCHEARTFAILURE.114.001279;

Quiroz R, Doros G, Shaw P, Liang CS, Gauthier DF, Sam F. Comparison of characteristics and outcomes of patients with heart failure preserved ejection fraction versus reduced left ventricular ejection fraction in an urban cohort. Am J Cardiol. 2014 Feb 15; 113(4):691-6.View Related Profiles.

Liang, Chang-seng
Gauthier, Diane
Sam, Flora
Doros, Gheorghe
Shaw, Peter

PMID: 24484862; DOI: 10.1016/j.amjcard.2013.11.014;

Essick EE, Wilson RM, Pimentel DR, Shimano M, Baid S, Ouchi N, Sam F. Adiponectin modulates oxidative stress-induced autophagy in cardiomyocytes. PLoS One. 2013; 8(7):e68697.View Related Profiles.

Pimentel, David
Sam, Flora

PMID: 23894332; PMCID: PMC3716763; DOI: 10.1371/journal.pone.0068697;

Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJ, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ, Wilkoff BL. 2013 ACCF/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2013 Oct 15; 128(16):1810-52. PMID: 23741057; DOI: 10.1161/CIR.0b013e31829e8807;

Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJ, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ, Wilkoff BL. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2013 Oct 15; 128(16):e240-327. PMID: 23741058; DOI: 10.1161/CIR.0b013e31829e8776;

Yancy CW, Jessup M, Bozkurt B, Masoudi FA, Butler J, McBride PE, Casey DE, McMurray JJ, Drazner MH, Mitchell JE, Fonarow GC, Peterson PN, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ, Wilkoff BL. 2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013 Jun 5. PMID: 23747641; DOI: 10.1016/j.jacc.2013.05.020;

Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJ, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ, Wilkoff BL. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013 Oct 15; 62(16):e147-239. PMID: 23747642; DOI: 10.1016/j.jacc.2013.05.019;

Ayalon N, Flore LA, Christensen TG, Sam F. Mitochondrial encoded NADH dehydrogenase 5 (MT-ND5) gene point mutation presents as late onset cardiomyopathy. Int J Cardiol. 2013 Sep 1; 167(5):e143-5.View Related Profiles.

Sam, Flora
Ayalon, Nir
Christensen, Thomas

PMID: 23628297; DOI: 10.1016/j.ijcard.2013.04.018;

Gopal DM, Sam F. New and emerging biomarkers in left ventricular systolic dysfunction--insight into dilated cardiomyopathy. J Cardiovasc Transl Res. 2013 Aug; 6(4):516-27.View Related Profiles.

Gopal, Deepa
Sam, Flora

PMID: 23609585; PMCID: PMC3713095; DOI: 10.1007/s12265-013-9462-3;

Tanaka K, Essick EE, Doros G, Tanriverdi K, Connors LH, Seldin DC, Sam F. Circulating matrix metalloproteinases and tissue inhibitors of metalloproteinases in cardiac amyloidosis. J Am Heart Assoc. 2013 Apr; 2(2):e005868.View Related Profiles.

Seldin, David
Sam, Flora
Doros, Gheorghe
Tanaka, Komei
Connors, Lawreen

PMID: 23537813; PMCID: PMC3647258; DOI: 10.1161/JAHA.112.005868;

Garcia AG, Wilson RM, Heo J, Murthy NR, Baid S, Ouchi N, Sam F. Interferon-? ablation exacerbates myocardial hypertrophy in diastolic heart failure. Am J Physiol Heart Circ Physiol. 2012 Sep 1; 303(5):H587-96. PMID: 22730392; PMCID: PMC3468473; DOI: 10.1152/ajpheart.00298.2012;

Shimano M, Ouchi N, Nakamura K, van Wijk B, Ohashi K, Asaumi Y, Higuchi A, Pimentel DR, Sam F, Murohara T, van den Hoff MJ, Walsh K. Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):E899-906.View Related Profiles.

Pimentel, David
Sam, Flora
Nakamura, Kazuto
Walsh, Kenneth
Ohashi, Koji
Asaumi, Yasuhide

PMID: 21987816; PMCID: PMC3203781; DOI: 10.1073/pnas.1108559108;

Aprahamian TR, Sam F. Adiponectin in cardiovascular inflammation and obesity. Int J Inflam. 2011; 2011:376909.View Related Profiles.

Sam, Flora
Aprahamian, Tamar

PMID: 21941676; PMCID: PMC3175407; DOI: 10.4061/2011/376909;

Essick EE, Ouchi N, Wilson RM, Ohashi K, Ghobrial J, Shibata R, Pimentel DR, Sam F. Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling. Am J Physiol Heart Circ Physiol. 2011 Sep; 301(3):H984-93.View Related Profiles.

Pimentel, David
Sam, Flora
Ohashi, Koji

PMID: 21666115; PMCID: PMC3191107; DOI: 10.1152/ajpheart.00428.2011;

Seldin DC, Andrea N, Berenbaum I, Berk JL, Connors L, Dember LM, Doros G, Fennessey S, Finn K, Girnius S, Lerner A, Libbey C, Meier-Ewert HK, O'Connell R, O'Hara C, Quillen K, Ruberg FL, Sam F, Segal A, Shelton A, Skinner M, Sloan JM, Wiesman JF, Sanchorawala V. High-dose melphalan and autologous stem cell transplantation for AL amyloidosis: recent trends in treatment-related mortality and 1-year survival at a single institution. Amyloid. 2011 Jun; 18 Suppl 1:127-9.View Related Profiles.

Lerner, Adam
O'Hara, Carl
Libbey, Caryn
Seldin, David
Sam, Flora
Ruberg, Frederick
Doros, Gheorghe
Meier-Ewert, Hans Kilian
Berenbaum, Isidore
Sloan, J.
Wiesman, Janice
Berk, John
Quillen, Karen
Dember, Laura
Connors, Lawreen
Skinner, Martha
Sanchorawala, Vaishali

PMID: 21838459; PMCID: PMC5601311; DOI: 10.3109/13506129.2011.574354047;

Connors LH, Doros G, Sam F, Badiee A, Seldin DC, Skinner M. Clinical features and survival in senile systemic amyloidosis: comparison to familial transthyretin cardiomyopathy. Amyloid. 2011 Jun; 18 Suppl 1:157-9.View Related Profiles.

Seldin, David
Sam, Flora
Doros, Gheorghe
Connors, Lawreen

PMID: 21838471; PMCID: PMC5603797; DOI: 10.3109/13506129.2011.574354059;

El-Armouche A, Ouchi N, Tanaka K, Doros G, Wittköpper K, Schulze T, Eschenhagen T, Walsh K, Sam F. Follistatin-like 1 in chronic systolic heart failure: a marker of left ventricular remodeling. Circ Heart Fail. 2011 Sep; 4(5):621-7.View Related Profiles.

Sam, Flora
Doros, Gheorghe
Walsh, Kenneth

PMID: 21622850; PMCID: PMC3178753; DOI: 10.1161/CIRCHEARTFAILURE.110.960625;

Essick EE, Sam F. Cardiac hypertrophy and fibrosis in the metabolic syndrome: a role for aldosterone and the mineralocorticoid receptor. Int J Hypertens. 2011; 2011:346985. PMID: 21747976; PMCID: PMC3124304; DOI: 10.4061/2011/346985;

Seldin DC, Berk JL, Sam F, Sanchorawala V. Amyloidotic cardiomyopathy: multidisciplinary approach to diagnosis and treatment. Heart Fail Clin. 2011 Jul; 7(3):385-93.View Related Profiles.

Seldin, David
Sam, Flora
Berk, John
Sanchorawala, Vaishali

PMID: 21749890; PMCID: PMC3135875; DOI: 10.1016/j.hfc.2011.03.009;

Shimano M, Ouchi N, Nakamura K, Oshima Y, Higuchi A, Pimentel DR, Panse KD, Lara-Pezzi E, Lee SJ, Sam F, Walsh K. Cardiac myocyte-specific ablation of follistatin-like 3 attenuates stress-induced myocardial hypertrophy. J Biol Chem. 2011 Mar 18; 286(11):9840-8.View Related Profiles.

Pimentel, David
Sam, Flora
Nakamura, Kazuto
Walsh, Kenneth

PMID: 21245136; PMCID: PMC3058981; DOI: 10.1074/jbc.M110.197079;

Greene MJ, Sam F, Soo Hoo PT, Patel RS, Seldin DC, Connors LH. Evidence for a functional role of the molecular chaperone clusterin in amyloidotic cardiomyopathy. Am J Pathol. 2011 Jan; 178(1):61-8.View Related Profiles.

Seldin, David
Sam, Flora
Connors, Lawreen

PMID: 21224044; PMCID: PMC3070592; DOI: 10.1016/j.ajpath.2010.11.015;

Essick EE, Sam F. Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer. Oxid Med Cell Longev. 2010 May-Jun; 3(3):168-77. PMID: 20716941; PMCID: PMC2952075; DOI: 10.4161/oxim.3.3.12106;

Quiroz R, Joseph L, Sam F. Serial troponin-I measurement as a diagnostic and therapeutic tool in chronic myocarditis. J Heart Lung Transplant. 2010 Jul; 29(7):820-2.View Related Profiles.

Sam, Flora
Joseph, Lija

PMID: 20417129; PMCID: PMC2904438; DOI: 10.1016/j.healun.2010.03.006;

Biolo A, Shibata R, Ouchi N, Kihara S, Sonoda M, Walsh K, Sam F. Determinants of adiponectin levels in patients with chronic systolic heart failure. Am J Cardiol. 2010 Apr 15; 105(8):1147-52.View Related Profiles.

Sam, Flora
Walsh, Kenneth

PMID: 20381668; PMCID: PMC2854672; DOI: 10.1016/j.amjcard.2009.12.015;

Don-Wauchope AC, Karas A, Chetty VT, Davidson HK, Gottschalk R, Rabiner EA, Sam F, Sommerville GP, Swartz J, Viljoen A. State hospitals, academic medicine and the decline of health care in South Africa - a cry of support from those who have left for those who stay. S Afr Med J. 2010 Feb; 100(2):74-5. PMID: 20459900

Ikeda Y, Sato K, Pimentel DR, Sam F, Shaw RJ, Dyck JR, Walsh K. Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction. J Biol Chem. 2009 Dec 18; 284(51):35839-49.View Related Profiles.

Pimentel, David
Sam, Flora
Walsh, Kenneth

PMID: 19828446; PMCID: PMC2791013; DOI: 10.1074/jbc.M109.057273;

Sam F, Walsh K. What can adiponectin say about left ventricular function? Heart. 2010 Mar; 96(5):331-2.View Related Profiles.

Sam, Flora
Walsh, Kenneth

PMID: 19934101; PMCID: PMC3673540; DOI: 10.1136/hrt.2009.178590;

Sam F, Duhaney TA, Sato K, Wilson RM, Ohashi K, Sono-Romanelli S, Higuchi A, De Silva DS, Qin F, Walsh K, Ouchi N. Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure. Endocrinology. 2010 Jan; 151(1):322-31.View Related Profiles.

Sam, Flora
Qin, Fuzhong
Walsh, Kenneth
Ohashi, Koji

PMID: 19850745; PMCID: PMC2803144; DOI: 10.1210/en.2009-0806;

Wilson RM, De Silva DS, Sato K, Izumiya Y, Sam F. Effects of fixed-dose isosorbide dinitrate/hydralazine on diastolic function and exercise capacity in hypertension-induced diastolic heart failure. Hypertension. 2009 Sep; 54(3):583-90. PMID: 19620510; DOI: 10.1161/HYPERTENSIONAHA.109.134932;

De Silva DS, Wilson RM, Hutchinson C, Ip PC, Garcia AG, Lancel S, Ito M, Pimentel DR, Sam F. Fenofibrate inhibits aldosterone-induced apoptosis in adult rat ventricular myocytes via stress-activated kinase-dependent mechanisms. Am J Physiol Heart Circ Physiol. 2009 Jun; 296(6):H1983-93.View Related Profiles.

Pimentel, David
Sam, Flora

PMID: 19395558; PMCID: PMC2716095; DOI: 10.1152/ajpheart.00002.2009;

Jain M, Jakubowski A, Cui L, Shi J, Su L, Bauer M, Guan J, Lim CC, Naito Y, Thompson JS, Sam F, Ambrose C, Parr M, Crowell T, Lincecum JM, Wang MZ, Hsu YM, Zheng TS, Michaelson JS, Liao R, Burkly LC. A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. Circulation. 2009 Apr 21; 119(15):2058-68. PMID: 19349318; PMCID: PMC2924152; DOI: 10.1161/CIRCULATIONAHA.108.837286;

Biolo A, Ramamurthy S, Connors LH, O'Hara CJ, Meier-Ewert HK, Soo Hoo PT, Sawyer DB, Seldin DC, Seldin DS, Sam F. Matrix metalloproteinases and their tissue inhibitors in cardiac amyloidosis: relationship to structural, functional myocardial changes and to light chain amyloid deposition. Circ Heart Fail. 2008 Nov; 1(4):249-57.View Related Profiles.

O'Hara, Carl
Seldin, David
Sam, Flora
Meier-Ewert, Hans Kilian
Connors, Lawreen

PMID: 19808299; PMCID: PMC2774449; DOI: 10.1161/CIRCHEARTFAILURE.108.788687;

Lebrasseur NK, Duhaney TA, De Silva DS, Cui L, Ip PC, Joseph L, Sam F. Effects of fenofibrate on cardiac remodeling in aldosterone-induced hypertension. Hypertension. 2007 Sep; 50(3):489-96.View Related Profiles.

Sam, Flora
Cui, Libin
Joseph, Lija

PMID: 17606858

Biolo A, Chao T, Duhaney TA, Kotlyar E, Allensworth-Davies D, Loscalzo J, Sam F. Usefulness of the aldosterone synthase gene polymorphism C-344-T to predict cardiac remodeling in African-Americans versus non-African-Americans with chronic systolic heart failure. Am J Cardiol. 2007 Jul 15; 100(2):285-90. PMID: 17631084

Shibata R, Izumiya Y, Sato K, Papanicolaou K, Kihara S, Colucci WS, Sam F, Ouchi N, Walsh K. Adiponectin protects against the development of systolic dysfunction following myocardial infarction. J Mol Cell Cardiol. 2007 Jun; 42(6):1065-74.View Related Profiles.

Sam, Flora
Colucci, Wilson

PMID: 17499764; PMCID: PMC1987393; DOI: 10.1016/j.yjmcc.2007.03.808;

Duhaney TA, Cui L, Rude MK, Lebrasseur NK, Ngoy S, De Silva DS, Siwik DA, Liao R, Sam F. Peroxisome proliferator-activated receptor alpha-independent actions of fenofibrate exacerbates left ventricular dilation and fibrosis in chronic pressure overload. Hypertension. 2007 May; 49(5):1084-94.View Related Profiles.

Siwik, Deborah
Sam, Flora
Cui, Libin

PMID: 17353509

Sam F, Halickman I, Vita JA, Levitzky Y, Cupples LA, Loscalzo J, Allensworth-Davies D. Predictors of improved left ventricular systolic function in an urban cardiomyopathy program. Am J Cardiol. 2006 Dec 15; 98(12):1622-6.View Related Profiles.

Sam, Flora
Vita, Joseph
Cupples, L

PMID: 17145222

Sam F, Siwik DA. Digesting the remodeled heart: role of lysosomal cysteine proteases in heart failure. Hypertension. 2006 Nov; 48(5):830-1.View Related Profiles.

Siwik, Deborah
Sam, Flora

PMID: 16982959

Kotlyar E, Vita JA, Winter MR, Awtry EH, Siwik DA, Keaney JF, Sawyer DB, Cupples LA, Colucci WS, Sam F. The relationship between aldosterone, oxidative stress, and inflammation in chronic, stable human heart failure. J Card Fail. 2006 Mar; 12(2):122-7.View Related Profiles.

Siwik, Deborah
Awtry, Eric
Sam, Flora
Vita, Joseph
Cupples, L
Winter, Michael
Colucci, Wilson

PMID: 16520260

Sam F, Kerstetter DL, Pimental DR, Mulukutla S, Tabaee A, Bristow MR, Colucci WS, Sawyer DB. Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium. J Card Fail. 2005 Aug; 11(6):473-80.View Related Profiles.

Sam, Flora
Colucci, Wilson

PMID: 16105639

Rude MK, Duhaney TA, Kuster GM, Judge S, Heo J, Colucci WS, Siwik DA, Sam F. Aldosterone stimulates matrix metalloproteinases and reactive oxygen species in adult rat ventricular cardiomyocytes. Hypertension. 2005 Sep; 46(3):555-61.View Related Profiles.

Siwik, Deborah
Sam, Flora
Colucci, Wilson

PMID: 16043662

Kuster GM, Kotlyar E, Rude MK, Siwik DA, Liao R, Colucci WS, Sam F. Mineralocorticoid receptor inhibition ameliorates the transition to myocardial failure and decreases oxidative stress and inflammation in mice with chronic pressure overload. Circulation. 2005 Feb 1; 111(4):420-7.View Related Profiles.

Siwik, Deborah
Sam, Flora
Colucci, Wilson

PMID: 15687129

Vasan RS, Evans JC, Benjamin EJ, Levy D, Larson MG, Sundstrom J, Murabito JM, Sam F, Colucci WS, Wilson PW. Relations of serum aldosterone to cardiac structure: gender-related differences in the Framingham Heart Study. Hypertension. 2004 May; 43(5):957-62.View Related Profiles.

Benjamin, Emelia
Sam, Flora
Murabito, Joanne
Larson, Martin
Ramachandran, Vasan
Colucci, Wilson

PMID: 15007028

Shieh FK, Kotlyar E, Sam F. Aldosterone and cardiovascular remodelling: focus on myocardial failure. J Renin Angiotensin Aldosterone Syst. 2004 Mar; 5(1):3-13. PMID: 15136967

Sam F, Xie Z, Ooi H, Kerstetter DL, Colucci WS, Singh M, Singh K. Mice lacking osteopontin exhibit increased left ventricular dilation and reduced fibrosis after aldosterone infusion. Am J Hypertens. 2004 Feb; 17(2):188-93.View Related Profiles.

Sam, Flora
Colucci, Wilson

PMID: 14751663

Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S, Brenner DA, Siwik DA, Singh K, Apstein CS, Colucci WS. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Circ Res. 2001 Aug 17; 89(4):351-6.View Related Profiles.

Siwik, Deborah
Sam, Flora
Colucci, Wilson

PMID: 11509452

Trueblood NA, Xie Z, Communal C, Sam F, Ngoy S, Liaw L, Jenkins AW, Wang J, Sawyer DB, Bing OH, Apstein CS, Colucci WS, Singh K. Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin. Circ Res. 2001 May 25; 88(10):1080-7.View Related Profiles.

Sam, Flora
Colucci, Wilson

PMID: 11375279

Podesser BK, Siwik DA, Eberli FR, Sam F, Ngoy S, Lambert J, Ngo K, Apstein CS, Colucci WS. ET(A)-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H984-91.View Related Profiles.

Siwik, Deborah
Sam, Flora
Colucci, Wilson

PMID: 11179039

Sam F, Sawyer DB, Chang DL, Eberli FR, Ngoy S, Jain M, Amin J, Apstein CS, Colucci WS. Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart. Am J Physiol Heart Circ Physiol. 2000 Jul; 279(1):H422-8.View Related Profiles.

Sam, Flora
Colucci, Wilson

PMID: 10899082

Sam F, Colucci WS. Role of endothelin-1 in myocardial failure. Proc Assoc Am Physicians. 1999 Sep-Oct; 111(5):417-22.View Related Profiles.

Sam, Flora
Colucci, Wilson

PMID: 10519162

Sam F, Colucci WS. Endothelin-1 in heart failure: does it play a role? Cardiologia. 1998 Sep; 43(9):889-92.View Related Profiles.

Sam, Flora
Colucci, Wilson

PMID: 9859602

Eberli FR, Sam F, Ngoy S, Apstein CS, Colucci WS. Left-ventricular structural and functional remodeling in the mouse after myocardial infarction: assessment with the isovolumetrically-contracting Langendorff heart. J Mol Cell Cardiol. 1998 Jul; 30(7):1443-7.View Related Profiles.

Sam, Flora
Colucci, Wilson

PMID: 9710811

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 90 publications over 26 distinct years, with a maximum of 9 publications in 2011 and 2013

Bar chart showing 90 publications over 26 distinct years, with a maximum of 9 publications in 2011 and 2013

Year	Publications
1998	2
1999	1
2000	1
2001	3
2004	3
2005	3
2006	3
2007	4
2008	1
2009	6
2010	5
2011	9
2012	1
2013	9
2014	2
2015	5
2016	3
2017	2
2018	2
2019	4
2020	2
2021	5
2022	5
2023	3
2024	1
2025	5

2018 Association of University Cardiologists: Elected Member, Association of University Cardiologists (AUC)

2016 Heart Failure Society of America: Fellow of the Heart Failure Society of America (FHFSA)

2011 American Society of Clinical Investigation: Member, American Society of Clinical Investigation (ASCI)

2009 American Heart Association: Fellow of the American Heart Association (FAHA)

2003 American College of Cardiology: Fellow of the American College of Cardiology (FACC)

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

cardiac amyloidosis
cardiac scleroderma
cardiomyopathy
diastolic heart failure (Heart Failure Preserved Ejection Fraction)
hypertrophy and cardiac remodeling
systolic heart failure (Heart Failure Reduced Ejection Fraction)

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