Alexa Beiser, PhD
Professor
Boston University School of Public Health
Dept of Biostatistics

PhD, Boston University
MA, University of California, San Diego




Alexa Beiser has been on the faculty at Boston University School of Public Health since 1985, engaged in teaching and collaborative public health research; she co-developed the doctoral program in biostatistics; co-directed the biostatistics program from 2000-2004, and served as Associate Chair for Education from 2015-2018. She formerly taught and coordinated the sections of Introduction to Statistical Computing. For more than twenty-five years, Dr. Beiser has served as the lead biostatistician for the Framingham Heart Study (FHS) neurology group, examining risk factors and prevalence and incidence of clinical and sub-clinical neurological outcomes including MRI and PET measures of brain structure, cognitive performance, dementia, Alzheimer’s disease, stroke, Parkinson’s disease, and epilepsy. Dr. Beiser currently leads the FHS neurology group data management team, responsible for surveillance and tracking of incident dementia, for supervision of recruitment of participants for various grant-funded studies, and for management of data collected at FHS as well as those measured or processed at other institutions (e.g., brain MRI or PET scans); and the FHS neurology group biostatistics team of six biostatisticians. Decades of examining risk factors for neurological diseases has naturally led to studying factors associated with accelerated brain aging. Dr. Beiser has coauthored FHS publications relating risk factors including midlife vascular factors, plasma homocysteine, plasma leptin levels, cardiac index, red blood cell omega-3 fatty acids, metabolic dysregulation, visceral fat, air pollution; serum brain-derived neurotrophic factor; and insulin-like growth factor 1, to measures of brain aging. Dr. Beiser also has made use of the richness of the multigenerational Framingham data to relate documented parental dementia and stroke to offspring stroke, cognitive performance, and MRI measures of brain structure. In investigations of clinical neurological endpoints, she has applied competing risk analyses and has also been able to investigate temporal trends in prevalent and incident neurological disease due to the availability of event surveillance over many decades. In all these studies, Dr. Beiser plays a key role in project conceptualization, is responsible for supervision of statistical data management, analysis, and interpretation of results, and contributes to manuscript preparation and critical review.

Professor
Boston University School of Medicine
Neurology


Investigator
Framingham Heart Study


Associate Chair
Boston University School of Public Health
Biostatistics


Boston Medical Center




The Clinical Significance of Incidental White Matter Lesions on MRI Amongst a Diverse Population with Cognitive Complaints (INDEED)
09/30/2020 - 08/31/2026 (Subcontract PI)
University of California, Davis NIH NINDS
1U19NS120384-01

Contributions of sleep to preclinical and clinical Alzheimer's disease
04/01/2020 - 02/28/2024 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA
1R01AG062531-01A1

Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE Consortium
09/15/2018 - 07/31/2021 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NINDS
5UH3NS100605-05

Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer Disease in Framingham Cohorts
12/01/2017 - 05/31/2021 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA
5R01AG054076-05

Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE Consortium
12/01/2017 - 09/14/2018 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NINDS
7UH3NS100605-03



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Salinas J, O'Donnell A, Kojis DJ, Pase MP, DeCarli C, Rentz DM, Berkman LF, Beiser A, Seshadri S. Association of Social Support With Brain Volume and Cognition. JAMA Netw Open. 2021 Aug 02; 4(8):e2121122.View Related Profiles. PMID: 34398201
     
  2. Baril AA, Beiser AS, Sanchez E, Mysliwiec V, Redline S, Gottlieb DJ, O'Connor GT, Gonzales MM, Himali D, Seshadri S, Himali JJ, Pase MP. Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype. Alzheimers Dement. 2021 Jul 26.View Related Profiles. PMID: 34310026; DOI: 10.1002/alz.12405;
     
  3. Suzuki H, Davis-Plourde K, Beiser A, Kunimura A, Miura K, DeCarli C, Maillard P, Mitchell GF, Vasan RS, Seshadri S, Fujiyoshi A. Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study. Circ Cardiovasc Imaging. 2021 Jul; 14(7):e011753.View Related Profiles. PMID: 34256573; PMCID: PMC8323993; DOI: 10.1161/CIRCIMAGING.120.011753;
     
  4. Cooper LL, Wang N, Beiser AS, Romero JR, Aparicio HJ, Lioutas VA, Benjamin EJ, Larson MG, Vasan RS, Mitchell GF, Seshadri S, Hamburg NM. Digital Peripheral Arterial Tonometry and Cardiovascular Disease Events: The Framingham Heart Study. Stroke. 2021 Aug; 52(9):2866-2873.View Related Profiles. PMID: 34192894; PMCID: PMC8378441; DOI: 10.1161/STROKEAHA.120.031102;
     
  5. Damotte V, van der Lee SJ, Chouraki V, Grenier-Boley B, Simino J, Adams H, Tosto G, White C, Terzikhan N, Cruchaga C, Knol MJ, Li S, Schraen S, Grove ML, Satizabal C, Amin N, Berr C, Younkin S, Gottesman RF, Buée L, Beiser A, Knopman DS, Uitterlinden A, DeCarli C, Bressler J, DeStefano A, Dartigues JF, Yang Q, Boerwinkle E, Tzourio C, Fornage M, Ikram MA, Amouyel P, de Jager P, Reitz C, Mosley TH, Lambert JC, Seshadri S, van Duijn CM. Plasma amyloid ß levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants. Alzheimers Dement. 2021 May 18.View Related Profiles. PMID: 34002480
     
  6. Stefanidou M, O'Donnell A, Himali JJ, DeCarli C, Satizabal C, Beiser AS, Seshadri S, Zaldy T. Bone Mineral Density Measurements and Association With Brain Structure and Cognitive Function: The Framingham Offspring Cohort. Alzheimer Dis Assoc Disord. 2021 May 11.View Related Profiles. PMID: 33973881; DOI: 10.1097/WAD.0000000000000453;
     
  7. Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S. Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study. Stroke. 2021 Jun; 52(6):2068-2076.View Related Profiles. PMID: 33874747; PMCID: PMC8154675; DOI: 10.1161/STROKEAHA.120.030601;
     
  8. Walker ME, O'Donnell AA, Himali JJ, Rajendran I, Melo van Lent D, Ataklte F, Jacques PF, Beiser AS, Seshadri S, Vasan RS, Xanthakis V. Associations of the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay diet with cardiac remodelling in the community: the Framingham Heart Study. Br J Nutr. 2021 Feb 23; 1-9.View Related Profiles. PMID: 33618785; PMCID: PMC8380746; DOI: 10.1017/S0007114521000660;
     
  9. Baril AA, Beiser AS, Redline S, McGrath ER, Aparicio HJ, Gottlieb DJ, Seshadri S, Pase MP, Himali JJ. Systemic inflammation as a moderator between sleep and incident dementia. Sleep. 2021 02 12; 44(2).View Related Profiles. PMID: 32860698; PMCID: PMC7879417; DOI: 10.1093/sleep/zsaa164;
     
  10. Lioutas VA, Ivan CS, Himali JJ, Aparicio HJ, Leveille T, Romero JR, Beiser AS, Seshadri S. Incidence of Transient Ischemic Attack and Association With Long-term Risk of Stroke. JAMA. 2021 01 26; 325(4):373-381.View Related Profiles. PMID: 33496774; PMCID: PMC7838926; DOI: 10.1001/jama.2020.25071;
     
Showing 10 of 308 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 308 publications over 35 distinct years, with a maximum of 29 publications in 2017

YearPublications
19841
19861
19882
19891
19914
19921
19937
19943
19953
19962
19974
19985
19994
20006
20013
20025
20035
200410
20054
20068
20074
20085
200911
20109
20118
201211
201315
201414
201525
201626
201729
201814
201926
202015
202117

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72 E. Concord St Robinson (B)
Boston MA 02118
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