Alexa Beiser, PhD
Professor
Boston University School of Public Health
Biostatistics

PhD, Boston University
MA, University of California, San Diego
BA, University of California, Santa Cruz



Alexa Beiser has been on the faculty at Boston University School of Public Health since 1985, engaged in teaching and collaborative public health research; she co-developed the doctoral program in biostatistics; co-directed the biostatistics program from 2000-2004, and served as Associate Chair for Education from 2015-2018. She formerly taught and coordinated the sections of Introduction to Statistical Computing. For more than twenty-five years, Dr. Beiser has served as the lead biostatistician for the Framingham Heart Study (FHS) neurology group, examining risk factors and prevalence and incidence of clinical and sub-clinical neurological outcomes including MRI and PET measures of brain structure, cognitive performance, dementia, Alzheimer’s disease, stroke, Parkinson’s disease, and epilepsy. Dr. Beiser currently leads the FHS neurology group data management team, responsible for surveillance and tracking of incident dementia, for supervision of recruitment of participants for various grant-funded studies, and for management of data collected at FHS as well as those measured or processed at other institutions (e.g., brain MRI or PET scans); and the FHS neurology group biostatistics team of six biostatisticians. Decades of examining risk factors for neurological diseases has naturally led to studying factors associated with accelerated brain aging. Dr. Beiser has coauthored FHS publications relating risk factors including midlife vascular factors, plasma homocysteine, plasma leptin levels, cardiac index, red blood cell omega-3 fatty acids, metabolic dysregulation, visceral fat, air pollution; serum brain-derived neurotrophic factor; and insulin-like growth factor 1, to measures of brain aging. Dr. Beiser also has made use of the richness of the multigenerational Framingham data to relate documented parental dementia and stroke to offspring stroke, cognitive performance, and MRI measures of brain structure. In investigations of clinical neurological endpoints, she has applied competing risk analyses and has also been able to investigate temporal trends in prevalent and incident neurological disease due to the availability of event surveillance over many decades. In all these studies, Dr. Beiser plays a key role in project conceptualization, is responsible for supervision of statistical data management, analysis, and interpretation of results, and contributes to manuscript preparation and critical review.

Professor
Boston University Chobanian & Avedisian School of Medicine
Neurology


Investigator
Framingham Heart Study


Associate Chair
Boston University School of Public Health
Biostatistics


Boston Medical Center




The Clinical Significance of Incidental White Matter Lesions on MRI Amongst a Diverse Population with Cognitive Complaints (INDEED)
09/30/2020 - 08/31/2026 (Subcontract PI)
University of California, Davis NIH NINDS
5U19NS120384-03

Multidimensional Assessment of Brain Health as A Marker of Dementia Risk and Resilience in the Framingham Study
09/15/2020 - 05/31/2025 (Subcontract PI)
PI: Vasan S. Ramachandran, MD
University of Texas Health Science Center at San Antonio NIH NIA
5R01AG066524-03

Contributions of sleep to preclinical and clinical Alzheimer's disease
04/01/2020 - 02/28/2025 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA
5R01AG062531-04

Blood-based biomarkers for early detection of preclinical neurocognitive disorders
12/01/2021 - 11/30/2023 (PI)
National University of Ireland Galway


Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)
09/01/2018 - 06/30/2023 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA
1RF1AG059421-01

Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer Disease in Framingham Cohorts
12/01/2017 - 05/31/2023 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NIA
5R01AG054076-05

Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE Consortium
09/15/2018 - 07/31/2022 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NINDS
5UH3NS100605-05

Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE Consortium
12/01/2017 - 09/14/2018 (Subcontract PI)
University of Texas Health Science Center at San Antonio NIH NINDS
7UH3NS100605-03



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. DeCarli C, Maillard P, Pase MP, Beiser AS, Kojis D, Satizabal CL, Himali JJ, Aparicio HJ, Fletcher E, Seshadri S. Trends in Intracranial and Cerebral Volumes of Framingham Heart Study Participants Born 1930 to 1970. JAMA Neurol. 2024 May 01; 81(5):471-480.View Related Profiles. PMID: 38526486; PMCID: PMC10964161; DOI: 10.1001/jamaneurol.2024.0469;
     
  2. Kelly DM, Pinheiro AA, Koini M, Anderson CD, Aparicio H, Hofer E, Kern D, Blacker D, DeCarli C, Hwang SJ, Viswanathan A, Gonzales MM, Beiser AS, Seshadri S, Schmidt R, Demissie S, Romero JR. Impaired Kidney Function, Cerebral Small Vessel Disease and Cognitive Disorders: The Framingham Heart Study. Nephrol Dial Transplant. 2024 Apr 02.View Related Profiles. PMID: 38565317
     
  3. Weinstein G, Kojis DJ, Ghosh S, Beiser AS, Seshadri S. Association of Neurotrophic Factors at Midlife With In Vivo Measures of ß-Amyloid and Tau Burden 15 Years Later in Dementia-Free Adults. Neurology. 2024 Apr 09; 102(7):e209198.View Related Profiles. PMID: 38471064
     
  4. Pase MP, Himali JJ, Puerta R, Beiser AS, Gonzales MM, Satizabal CL, Yang Q, Aparicio HJ, Kojis DJ, Decarli CS, Lopez OL, Longstreth W, Gudnason V, Mosley TH, Bis JC, Fohner A, Psaty BM, Boada M, García-González P, Valero S, Marquié M, Tracy R, Launer LJ, Ruiz A, Fornage M, Seshadri S. Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and Dementia. Neurology. 2024 Feb 27; 102(4):e208075.View Related Profiles. PMID: 38290090
     
  5. Satizabal CL, Beiser AS, Fletcher E, Seshadri S, DeCarli C. A novel neuroimaging signature for ADRD risk stratification in the community. Alzheimers Dement. 2024 Mar; 20(3):1881-1893.View Related Profiles. PMID: 38147416; PMCID: PMC10984488; DOI: 10.1002/alz.13600;
     
  6. Baril AA, Kojis DJ, Himali JJ, Decarli CS, Sanchez E, Johnson KA, El Fakhri G, Thibault E, Yiallourou SR, Himali D, Cavuoto MG, Pase MP, Beiser AS, Seshadri S. Association of Sleep Duration and Change Over Time With Imaging Biomarkers of Cerebrovascular, Amyloid, Tau, and Neurodegenerative Pathology. Neurology. 2024 Jan 09; 102(1):e207807.View Related Profiles. PMID: 38165370; PMCID: PMC10834132; DOI: 10.1212/WNL.0000000000207807;
     
  7. Himali JJ, Baril AA, Cavuoto MG, Yiallourou S, Wiedner CD, Himali D, DeCarli C, Redline S, Beiser AS, Seshadri S, Pase MP. Association Between Slow-Wave Sleep Loss and Incident Dementia. JAMA Neurol. 2023 Dec 01; 80(12):1326-1333.View Related Profiles. PMID: 37902739; PMCID: PMC10616771; DOI: 10.1001/jamaneurol.2023.3889;
     
  8. Liu M, Khasiyev F, Sariya S, Spagnolo-Allende A, Sanchez DL, Andrews H, Yang Q, Beiser A, Qiao Y, Thomas EA, Romero JR, Rundek T, Brickman AM, Manly JJ, Elkind MS, Seshadri S, Chen C, Hilal S, Wasserman BA, Tosto G, Fornage M, Gutierrez J. Chromosome 10q24.32 Variants Associate With Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study. J Am Heart Assoc. 2023 Dec 05; 12(23):e030935.View Related Profiles. PMID: 38038215; PMCID: PMC10727334; DOI: 10.1161/JAHA.123.030935;
     
  9. Lary CW, Ghatan S, Gerety M, Hinton A, Nagarajan A, Rosen C, Ross RD, Bennett DA, DeStefano AL, Ikram MA, Rivadeneira F, Kiel DP, Seshadri S, Beiser A. Bone mineral density and the risk of incident dementia: A meta-analysis. J Am Geriatr Soc. 2024 Jan; 72(1):194-200.View Related Profiles. PMID: 37933827; PMCID: PMC10829515; DOI: 10.1111/jgs.18638;
     
  10. Tin A, Fohner AE, Yang Q, Brody JA, Davies G, Yao J, Liu D, Caro I, Lindbohm JV, Duggan MR, Meirelles O, Harris SE, Gudmundsdottir V, Taylor AM, Henry A, Beiser AS, Shojaie A, Coors A, Fitzpatrick AL, Langenberg C, Satizabal CL, Sitlani CM, Wheeler E, Tucker-Drob EM, Bressler J, Coresh J, Bis JC, Candia J, Jennings LL, Pietzner M, Lathrop M, Lopez OL, Redmond P, Gerszten RE, Rich SS, Heckbert SR, Austin TR, Hughes TM, Tanaka T, Emilsson V, Vasan RS, Guo X, Zhu Y, Tzourio C, Rotter JI, Walker KA, Ferrucci L, Kivimäki M, Breteler MMB, Cox SR, Debette S, Mosley TH, Gudnason VG, Launer LJ, Psaty BM, Seshadri S, Fornage M. Identification of circulating proteins associated with general cognitive function among middle-aged and older adults. Commun Biol. 2023 Nov 03; 6(1):1117.View Related Profiles. PMID: 37923804; PMCID: PMC10624811; DOI: 10.1038/s42003-023-05454-1;
     
Showing 10 of 381 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 381 publications over 38 distinct years, with a maximum of 36 publications in 2022

YearPublications
19841
19861
19882
19891
19914
19921
19937
19943
19953
19962
19974
19985
19994
20006
20013
20025
20035
200410
20054
20068
20074
20085
200911
20109
20118
201211
201315
201414
201525
201626
201729
201814
201926
202015
202122
202236
202328
20244

Contact for Mentoring:

72 E. Concord St Robinson (B)
Boston MA 02118
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