Tamar Aprahamian | Profiles RNS

Tamar R. Aprahamian, PhD

Voluntary Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Nephrology

PhD, Tufts University
BS, Boston College

Websites

	LinkedIn
	ResearchGate
	Loop Frontiers

ORCID : 0000-0001-9295-5995

Tamar Aprahamian, PhD is an Assistant Professor of Nephrology at the Chobanian and Avedisian School of Medicine. Dr. Aprahamian returned to the university in 2017, after a year-long stint as Principal Scientist for Cobalt Biomedicine, where she was named as inventor on 9 patents and led the preclinical development, design, and analysis of data. She is also the founder of JetPub Scientific Communications. The company specializes in writing services for academic institutions, pharmaceutical, biotechnology, and medical device companies.

Dr. Aprahamian's research interests are influenced by her 12 years in the BUSM renal section and include adipose tissue biology, in vivo efficacy testing, and drug target validation.

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Associate Member
Boston University Medical Center
Boston Nutrition Obesity Research Center

Boston Medical Center

CardioVax Project
11/01/2013 - 12/31/2016 (PI)
CardioVax

Angiogenic Potential and Thermogenic Response of Brown Adipose Tissue
04/01/2012 - 03/31/2015 (Subcontract PI)
Boston Medical Center Corporation NIH NIDDK
5P30DK046200-22

The Role of Retinaldehyde and Adipogenesis in the Progression of Systemic Lupus Erythematos
06/01/2014 - 08/15/2014 (PI)
The Lupus Foundation of America, Inc.

A Novel Mouse Model to Study Accelerated Atherosclerosis in SLE: A Possible Role for Statin Treatment
06/01/2004 - 09/01/2004 (PI)
The Lupus Foundation of America, Inc.

Role of PPARgamma signaling and adiponectin in Systemic Lupus Erythematosus
07/01/2009 - 06/30/2015 (PI)
NIH-NIAMS
5K01 AR055965-05

Title

Yr	Title	Project-Sub Proj	Pubs
2013	Role of PPARgamma signaling and adiponectin in Systemic Lupus Erythematosus	5K01AR055965-05	9
2012	Role of PPARgamma signaling and adiponectin in Systemic Lupus Erythematosus	5K01AR055965-04	9
2011	Role of PPARgamma signaling and adiponectin in Systemic Lupus Erythematosus	5K01AR055965-03	9
2010	Role of PPARgamma signaling and adiponectin in Systemic Lupus Erythematosus	5K01AR055965-02	9
2009	Role of PPARgamma signaling and adiponectin in Systemic Lupus Erythematosus	1K01AR055965-01A1	9

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Gharakhanian R, Su S, Aprahamian T. Vascular Endothelial Growth Factor-A Deficiency in Perivascular Adipose Tissue Impairs Macrovascular Function. Front Physiol. 2019; 10:687. PMID: 31258484; PMCID: PMC6587635; DOI: 10.3389/fphys.2019.00687;

MacLauchlan S, Zuriaga MA, Fuster JJ, Cuda CM, Jonason J, Behzadi F, Duffen JP, Haines GK, Aprahamian T, Perlman H, Walsh K. Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis. Arthritis Res Ther. 2017 Jul 19; 19(1):166.View Related Profiles.

Fuster Ortuno, Jose
Walsh, Kenneth
Zuriaga Herrero, Maria
Maclauchlan, Susan
Aprahamian, Tamar

PMID: 28724439; PMCID: PMC5518154; DOI: 10.1186/s13075-017-1375-0;

Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 2017 Jul; 18(7):1123-1138.View Related Profiles.

Corkey, Barbara
Benador, Ilan
Mahdaviani, Kiana
Trudeau, Kyle
Cardamone, Maria
Shirihai, Orian
Aprahamian, Tamar
Perissi, Valentina

PMID: 28539390; PMCID: PMC5887905; DOI: 10.15252/embr.201643827;

Wang H, Liu L, Lin JZ, Aprahamian TR, Farmer SR. Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1+ Adipocytes. Cell Metab. 2016 Dec 13; 24(6):835-847.View Related Profiles.

Liu, Libin
Farmer, Stephen
Aprahamian, Tamar

PMID: 27974179; PMCID: PMC6674884; DOI: 10.1016/j.cmet.2016.10.005;

Valero-Muñoz M, Li S, Wilson RM, Hulsmans M, Aprahamian T, Fuster JJ, Nahrendorf M, Scherer PE, Sam F. Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue. Circ Heart Fail. 2016 Jan; 9(1):e002724.View Related Profiles.

Sam, Flora
Fuster Ortuno, Jose
Valero Munoz, Maria
Aprahamian, Tamar

PMID: 26721917; PMCID: PMC4698901; DOI: 10.1161/CIRCHEARTFAILURE.115.002724;

Duffau P, Menn-Josephy H, Cuda CM, Dominguez S, Aprahamian TR, Watkins AA, Yasuda K, Monach P, Lafyatis R, Rice LM, Kenneth Haines G, Gravallese EM, Baum R, Richez C, Perlman H, Bonegio RG, Rifkin IR. Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model. Arthritis Rheumatol. 2015 Dec; 67(12):3146-57.View Related Profiles.

Watkins, Amanda
Menn-Josephy, Hanni
Rifkin, Ian
Yasuda, Kei
Rice, Lisa
Monach, Paul
Bonegio, Ramon
Lafyatis, Robert
Aprahamian, Tamar

PMID: 26315890; PMCID: PMC4661118; DOI: 10.1002/art.39321;

Mahdaviani K, Chess D, Wu Y, Shirihai O, Aprahamian TR. Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes. Metabolism. 2016 Jan; 65(1):26-35.View Related Profiles.

Mahdaviani, Kiana
Shirihai, Orian
Aprahamian, Tamar
Wu, Yuanyuan

PMID: 26683794; PMCID: PMC4684900; DOI: 10.1016/j.metabol.2015.09.012;

Kambara T, Shibata R, Ohashi K, Matsuo K, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Ogawa H, Aprahamian T, Walsh K, Murohara T, Ouchi N. C1q/Tumor Necrosis Factor-Related Protein 9 Protects against Acute Myocardial Injury through an Adiponectin Receptor I-AMPK-Dependent Mechanism. Mol Cell Biol. 2015 Jun; 35(12):2173-85.View Related Profiles.

Walsh, Kenneth
Ohashi, Koji
Aprahamian, Tamar

PMID: 25870106; PMCID: PMC4438248; DOI: 10.1128/MCB.01518-14;

Aprahamian TR, Zhong X, Amir S, Binder CJ, Chiang LK, Al-Riyami L, Gharakhanian R, Harnett MM, Harnett W, Rifkin IR. The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model. Int J Parasitol. 2015 Mar; 45(4):203-7.View Related Profiles.

Rifkin, Ian
Aprahamian, Tamar
Zhong, Xuemei

PMID: 25666929; PMCID: PMC4355381; DOI: 10.1016/j.ijpara.2014.12.006;

Watkins AA, Yasuda K, Wilson GE, Aprahamian T, Xie Y, Maganto-Garcia E, Shukla P, Oberlander L, Laskow B, Menn-Josephy H, Wu Y, Duffau P, Fried SK, Lichtman AH, Bonegio RG, Rifkin IR. IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis. J Immunol. 2015 Feb 15; 194(4):1467-79.View Related Profiles.

Watkins, Amanda
Menn-Josephy, Hanni
Rifkin, Ian
Yasuda, Kei
Bonegio, Ramon
Fried, Susan
Aprahamian, Tamar
Wu, Yuanyuan

PMID: 25595782; PMCID: PMC4323680; DOI: 10.4049/jimmunol.1402807;

Showing 10 of 37 results. Show More

Fuster JJ, Zuriaga MA, Ngo DT, Farb MG, Aprahamian T, Yamaguchi TP, Gokce N, Walsh K. Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion. Diabetes. 2015 Apr; 64(4):1235-48.View Related Profiles.

Ngo, Doan
Fuster Ortuno, Jose
Walsh, Kenneth
Zuriaga Herrero, Maria
Farb, Melissa
Gokce, Noyan
Aprahamian, Tamar

PMID: 25352637; PMCID: PMC4375084; DOI: 10.2337/db14-1164;

Aprahamian TR, Bonegio RG, Weitzner Z, Gharakhanian R, Rifkin IR. Peroxisome proliferator-activated receptor gamma agonists in the prevention and treatment of murine systemic lupus erythematosus. Immunology. 2014 Jul; 142(3):363-73.View Related Profiles.

Rifkin, Ian
Bonegio, Ramon
Aprahamian, Tamar

PMID: 24456224; PMCID: PMC4080952; DOI: 10.1111/imm.12256;

Parker-Duffen JL, Nakamura K, Silver M, Zuriaga MA, MacLauchlan S, Aprahamian TR, Walsh K. Divergent roles for adiponectin receptor 1 (AdipoR1) and AdipoR2 in mediating revascularization and metabolic dysfunction in vivo. J Biol Chem. 2014 Jun 6; 289(23):16200-13.View Related Profiles.

Nakamura, Kazuto
Walsh, Kenneth
Zuriaga Herrero, Maria
Maclauchlan, Susan
Aprahamian, Tamar

PMID: 24742672; PMCID: PMC4047390; DOI: 10.1074/jbc.M114.548115;

Shimizu I, Aprahamian T, Kikuchi R, Shimizu A, Papanicolaou KN, MacLauchlan S, Maruyama S, Walsh K. Vascular rarefaction mediates whitening of brown fat in obesity. J Clin Invest. 2014 May 1; 124(5):2099-112.View Related Profiles.

Shimizu, Ippei
Walsh, Kenneth
Kikuchi, Ryosuke
Maruyama, Sonomi
Maclauchlan, Susan
Aprahamian, Tamar

PMID: 24713652; PMCID: PMC4001539; DOI: 10.1172/JCI71643;

Aprahamian TR. Elevated adiponectin expression promotes adipose tissue vascularity under conditions of diet-induced obesity. Metabolism. 2013 Dec; 62(12):1730-8. PMID: 23993424; PMCID: PMC3834157; DOI: 10.1016/j.metabol.2013.07.010;

Richez C, Richards RJ, Duffau P, Weitzner Z, Andry CD, Rifkin IR, Aprahamian T. The effect of mycophenolate mofetil on disease development in the gld.apoE (-/-) mouse model of accelerated atherosclerosis and systemic lupus erythematosus. PLoS One. 2013; 8(4):e61042.View Related Profiles.

Rifkin, Ian
Aprahamian, Tamar

PMID: 23577189; PMCID: PMC3620051; DOI: 10.1371/journal.pone.0061042;

Ding M, Carrão AC, Wagner RJ, Xie Y, Jin Y, Rzucidlo EM, Yu J, Li W, Tellides G, Hwa J, Aprahamian TR, Martin KA. Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype. J Mol Cell Cardiol. 2012 Feb; 52(2):474-84. PMID: 21952104; PMCID: PMC3264700; DOI: 10.1016/j.yjmcc.2011.09.008;

Aprahamian TR, Sam F. Adiponectin in cardiovascular inflammation and obesity. Int J Inflam. 2011; 2011:376909.View Related Profiles.

Sam, Flora
Aprahamian, Tamar

PMID: 21941676; PMCID: PMC3175407; DOI: 10.4061/2011/376909;

Ionescu LI, Alphonse RS, Arizmendi N, Morgan B, Abel M, Eaton F, Duszyk M, Vliagoftis H, Aprahamian TR, Walsh K, Thébaud B. Airway delivery of soluble factors from plastic-adherent bone marrow cells prevents murine asthma. Am J Respir Cell Mol Biol. 2012 Feb; 46(2):207-16. PMID: 21903873; PMCID: PMC3361359; DOI: 10.1165/rcmb.2010-0391OC;

Parker J, Menn-Josephy H, Laskow B, Takemura Y, Aprahamian T. Modulation of lupus phenotype by adiponectin deficiency in autoimmune mouse models. J Clin Immunol. 2011 Apr; 31(2):167-73.View Related Profiles.

Menn-Josephy, Hanni
Aprahamian, Tamar

PMID: 21063900; PMCID: PMC3505060; DOI: 10.1007/s10875-010-9486-2;

Richez C, Yasuda K, Bonegio RG, Watkins AA, Aprahamian T, Busto P, Richards RJ, Liu CL, Cheung R, Utz PJ, Marshak-Rothstein A, Rifkin IR. IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus. J Immunol. 2010 Jan 15; 184(2):796-806.View Related Profiles.

Watkins, Amanda
Marshak-Rothstein, Ann
Rifkin, Ian
Yasuda, Kei
Bonegio, Ramon
Aprahamian, Tamar

PMID: 20007534; PMCID: PMC2858062; DOI: 10.4049/jimmunol.0901748;

Aprahamian T, Bonegio RG, Richez C, Yasuda K, Chiang LK, Sato K, Walsh K, Rifkin IR. The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. J Immunol. 2009 Jan 1; 182(1):340-6.View Related Profiles.

Rifkin, Ian
Yasuda, Kei
Bonegio, Ramon
Aprahamian, Tamar

PMID: 19109165; PMCID: PMC2841959; DOI: 10.4049/jimmunol.182.1.340;

Straface G, Aprahamian T, Flex A, Gaetani E, Biscetti F, Smith RC, Pecorini G, Pola E, Angelini F, Stigliano E, Castellot JJ, Losordo DW, Pola R. Sonic hedgehog regulates angiogenesis and myogenesis during post-natal skeletal muscle regeneration. J Cell Mol Med. 2009 Aug; 13(8B):2424-35. PMID: 18662193; PMCID: PMC3132885; DOI: 10.1111/j.1582-4934.2008.00440.x;

Biscetti F, Gaetani E, Flex A, Straface G, Pecorini G, Angelini F, Stigliano E, Aprahamian T, Smith RC, Castellot JJ, Pola R. Peroxisome proliferator-activated receptor alpha is crucial for iloprost-induced in vivo angiogenesis and vascular endothelial growth factor upregulation. J Vasc Res. 2009; 46(2):103-8. PMID: 18617751; DOI: 10.1159/000143793;

Aprahamian T, Takemura Y, Goukassian D, Walsh K. Ageing is associated with diminished apoptotic cell clearance in vivo. Clin Exp Immunol. 2008 Jun; 152(3):448-55.View Related Profiles.

Goukassian, David
Aprahamian, Tamar

PMID: 18422728; PMCID: PMC2453212; DOI: 10.1111/j.1365-2249.2008.03658.x;

Summer R, Little FF, Ouchi N, Takemura Y, Aprahamian T, Dwyer D, Fitzsimmons K, Suki B, Parameswaran H, Fine A, Walsh K. Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1035-42.View Related Profiles.

Fine, Alan
Suki, Bela
Little, Frederic
Walsh, Kenneth
Aprahamian, Tamar

PMID: 18326826; PMCID: PMC3575679; DOI: 10.1152/ajplung.00397.2007;

Biscetti F, Gaetani E, Flex A, Aprahamian T, Hopkins T, Straface G, Pecorini G, Stigliano E, Smith RC, Angelini F, Castellot JJ, Pola R. Selective activation of peroxisome proliferator-activated receptor (PPAR)alpha and PPAR gamma induces neoangiogenesis through a vascular endothelial growth factor-dependent mechanism. Diabetes. 2008 May; 57(5):1394-404. PMID: 18268046; DOI: 10.2337/db07-0765;

Takemura Y, Ouchi N, Shibata R, Aprahamian T, Kirber MT, Summer RS, Kihara S, Walsh K. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest. 2007 Feb; 117(2):375-86.View Related Profiles.

Walsh, Kenneth
Kirber, Michael
Aprahamian, Tamar

PMID: 17256056; PMCID: PMC1770947; DOI: 10.1172/JCI29709;

Schiekofer S, Galasso G, Andrassy M, Aprahamian T, Schneider J, Rocnik E. Glucose control with insulin results in reduction of NF-kappaB-binding activity in mononuclear blood cells of patients with recently manifested type 1 diabetes. Diabetes Obes Metab. 2006 Sep; 8(5):473-82. PMID: 16918581

Aprahamian T, Bonegio R, Rizzo J, Perlman H, Lefer DJ, Rifkin IR, Walsh K. Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model. J Immunol. 2006 Sep 1; 177(5):3028-34.View Related Profiles.

Rifkin, Ian
Bonegio, Ramon
Aprahamian, Tamar

PMID: 16920939; PMCID: PMC2752011; DOI: 10.4049/jimmunol.177.5.3028;

Moussa CE, Fu Q, Kumar P, Shtifman A, Lopez JR, Allen PD, LaFerla F, Weinberg D, Magrane J, Aprahamian T, Walsh K, Rosen KM, Querfurth HW. Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology. FASEB J. 2006 Oct; 20(12):2165-7. PMID: 16940437

Pola R, Aprahamian TR, Bosch-Marcé M, Curry C, Gaetani E, Flex A, Smith RC, Isner JM, Losordo DW. Age-dependent VEGF expression and intraneural neovascularization during regeneration of peripheral nerves. Neurobiol Aging. 2004 Nov-Dec; 25(10):1361-8. PMID: 15465634

Yang J, Sato K, Aprahamian T, Brown NJ, Hutcheson J, Bialik A, Perlman H, Walsh K. Endothelial overexpression of Fas ligand decreases atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2004 Aug; 24(8):1466-73. PMID: 15178561

Aprahamian T, Rifkin I, Bonegio R, Hugel B, Freyssinet JM, Sato K, Castellot JJ, Walsh K. Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J Exp Med. 2004 Apr 19; 199(8):1121-31.View Related Profiles.

Rifkin, Ian
Walsh, Kenneth
Bonegio, Ramon
Aprahamian, Tamar

PMID: 15096538; PMCID: PMC2211887

Pola R, Gaetani E, Flex A, Aprahamian TR, Bosch-Marcé M, Losordo DW, Smith RC, Pola P. Comparative analysis of the in vivo angiogenic properties of stable prostacyclin analogs: a possible role for peroxisome proliferator-activated receptors. J Mol Cell Cardiol. 2004 Mar; 36(3):363-70. PMID: 15010275

Pola R, Gaetani E, Flex A, Aprahamian T, Proia AS, Bosch-Marcé M, Smith RC, Pola P. Peripheral nerve ischemia: apolipoprotein E deficiency results in impaired functional recovery and reduction of associated intraneural angiogenic response. Exp Neurol. 2003 Nov; 184(1):264-73. PMID: 14637097

Pola R, Ling LE, Aprahamian TR, Barban E, Bosch-Marce M, Curry C, Corbley M, Kearney M, Isner JM, Losordo DW. Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia. Circulation. 2003 Jul 29; 108(4):479-85. PMID: 12860919

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 37 publications over 14 distinct years, with a maximum of 5 publications in 2008 and 2015